Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research
Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research
Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research
Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research
Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research
Stabilization of a Cu-binding site by a highly conserved tryptophan residue
J Inorg Biochem. 2024 Feb 7;253:112501. doi: 10.1016/j.jinorgbio.2024.112501. Online ahead of print.ABSTRACTCopper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria import copper and maintain homeostasis. To obtain a better understanding of how these processes work, here we focus on the ycnKJI operon responsible for regulating copper levels in the Gram-positive bacterium Bacillus subtilis. This operon encodes three Cu-related proteins: a copper-dependent transcriptional repressor (YcnK), a putative copper importer (YcnJ), and ...
Source: Journal of Inorganic Biochemistry - February 11, 2024 Category: Biochemistry Authors: Yuri Rafael de Oliveira Silva Dia Zheng Stephen C Peters Oriana S Fisher Source Type: research
Stabilization of a Cu-binding site by a highly conserved tryptophan residue
J Inorg Biochem. 2024 Feb 7;253:112501. doi: 10.1016/j.jinorgbio.2024.112501. Online ahead of print.ABSTRACTCopper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria import copper and maintain homeostasis. To obtain a better understanding of how these processes work, here we focus on the ycnKJI operon responsible for regulating copper levels in the Gram-positive bacterium Bacillus subtilis. This operon encodes three Cu-related proteins: a copper-dependent transcriptional repressor (YcnK), a putative copper importer (YcnJ), and ...
Source: Journal of Inorganic Biochemistry - February 11, 2024 Category: Biochemistry Authors: Yuri Rafael de Oliveira Silva Dia Zheng Stephen C Peters Oriana S Fisher Source Type: research
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
J Inorg Biochem. 2024 Feb 6;253:112502. doi: 10.1016/j.jinorgbio.2024.112502. Online ahead of print.ABSTRACTCisplatin is a widely used chemotherapeutic agent which interacts with DNA to form Pt-DNA adducts, leading to DNA double-strand breaks and apoptosis. Resistance is the major obstacle in the clinical application of cisplatin. A quinoline derivative based Pt(II) complex PtQ was synthesized and characterized. As an analogue of cisplatin, PtQ demonstrated a novel anticancer mechanism in ovarian cancer. PtQ caused excessive production of reactive oxygen species (ROS), which triggered ferroptotic cell death in ovarian canc...
Source: Journal of Inorganic Biochemistry - February 9, 2024 Category: Biochemistry Authors: Xiaomin Shen Yue Peng Haixia Zhou Xiaoxia Ye Zhong Han Xiangchao Shi Source Type: research
The structure of the diheme cytochrome c < sub > 4 < /sub > from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials
J Inorg Biochem. 2024 Jan 24;253:112496. doi: 10.1016/j.jinorgbio.2024.112496. Online ahead of print.ABSTRACTCytochrome c4 (c4) is a diheme protein implicated as an electron donor to cbb3 oxidases in multiple pathogenic bacteria. Despite its prevalence, understanding of how specific structural features of c4 optimize its function is lacking. The human pathogen Neisseria gonorrhoeae (Ng) thrives in low oxygen environments owing to the activity of its cbb3 oxidase. Herein, we report characterization of Ng c4. Spectroelectrochemistry experiments of the wild-type (WT) protein have shown that the two Met/His-ligated hemes diffe...
Source: Journal of Inorganic Biochemistry - February 8, 2024 Category: Biochemistry Authors: Fangfang Zhong Morgan E Reik Michael J Ragusa Ekaterina V Pletneva Source Type: research
Anticancer behaviour of 2,2'-(pyridin-2-ylmethylene)bis(5,5-dimethylcyclohexane-1,3-dione)-based palladium(II) complex and its DNA, BSA binding propensity and DFT study
J Inorg Biochem. 2024 Jan 22;253:112488. doi: 10.1016/j.jinorgbio.2024.112488. Online ahead of print.ABSTRACTHerein, we report the synthesis and biological evaluation of [Pd(L)(OH2)Cl] complex (where L = 2,2'-(pyridin-2-ylmethylene)bis(5,5-dimethylcyclohexane-1,3-dione) as a novel promising anticancer candidate. The complex was characterized by single-crystal X-ray diffraction and other various spectroscopic techniques. Besides, the optimized structure was determined through DFT calculations revealing that the coordination geometry of [Pd(L)(OH2)Cl] complex is square planar. The binding propensity of [Pd(L)(OH2)Cl] complex...
Source: Journal of Inorganic Biochemistry - February 7, 2024 Category: Biochemistry Authors: Mohamed A Ragheb Marwa H Soliman Ismail A Abdelhamid Mohamed M Shoukry Matti Haukka Mona S Ragab Source Type: research
Investigating Cu(I) binding to model peptides of N-terminal A β isoforms
J Inorg Biochem. 2024 Jan 9;253:112480. doi: 10.1016/j.jinorgbio.2024.112480. Online ahead of print.ABSTRACTAmyloid beta (Aβ) peptides and copper (Cu) ions are each involved in critical biological processes including antimicrobial activity, regulation of synaptic function, angiogenesis, and others. Aβ binds to Cu and may play a role in Cu trafficking. Aβ peptides exist in isoforms that vary at their C-and N-termini; variation at the N-terminal sequence affects Cu binding affinity, structure, and redox activity by providing different sets of coordinating groups to the metal ion. Several N-terminal isoforms have been dete...
Source: Journal of Inorganic Biochemistry - February 3, 2024 Category: Biochemistry Authors: Abigail Strausbaugh Hjelmstad M Jake Pushie Kaylee Ruth Maria Escobedo Kristin Kuter Kathryn L Haas Source Type: research
