Finding the best location: Improving the anti-amyloid ability of ruthenium(III) complexes with pyridine ligands
J Inorg Biochem. 2023 Nov 7;250:112424. doi: 10.1016/j.jinorgbio.2023.112424. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurological disorder where one of the primary pathological hallmarks are aggregate deposits of the peptide amyloid-beta (Aβ). Although the Food and Drug Administration (FDA) has recently approved therapeutics that specifically target Aβ, resulting in the removal of these deposits, the associated costs of such treatments create a need for effective, yet cheaper, alternatives. Metal-based compounds are propitious therapeutic candidates as they exploit the metal-binding prope...
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Johanna T Ehlbeck Daniela M Grimard Ryan M Hacker Jimmy A Garcia Brendan J Wall Paige J Bothwell Marjorie A Jones Michael I Webb Source Type: research
Heme is pivotal for life
J Inorg Biochem. 2023 Oct 31:112423. doi: 10.1016/j.jinorgbio.2023.112423. Online ahead of print.NO ABSTRACTPMID:37953207 | DOI:10.1016/j.jinorgbio.2023.112423 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Massimo Coletta Martino Bolognesi Paolo Ascenzi Source Type: research
Finding the best location: Improving the anti-amyloid ability of ruthenium(III) complexes with pyridine ligands
J Inorg Biochem. 2023 Nov 7;250:112424. doi: 10.1016/j.jinorgbio.2023.112424. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurological disorder where one of the primary pathological hallmarks are aggregate deposits of the peptide amyloid-beta (Aβ). Although the Food and Drug Administration (FDA) has recently approved therapeutics that specifically target Aβ, resulting in the removal of these deposits, the associated costs of such treatments create a need for effective, yet cheaper, alternatives. Metal-based compounds are propitious therapeutic candidates as they exploit the metal-binding prope...
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Johanna T Ehlbeck Daniela M Grimard Ryan M Hacker Jimmy A Garcia Brendan J Wall Paige J Bothwell Marjorie A Jones Michael I Webb Source Type: research
Heme is pivotal for life
J Inorg Biochem. 2023 Oct 31:112423. doi: 10.1016/j.jinorgbio.2023.112423. Online ahead of print.NO ABSTRACTPMID:37953207 | DOI:10.1016/j.jinorgbio.2023.112423 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Massimo Coletta Martino Bolognesi Paolo Ascenzi Source Type: research
Finding the best location: Improving the anti-amyloid ability of ruthenium(III) complexes with pyridine ligands
J Inorg Biochem. 2023 Nov 7;250:112424. doi: 10.1016/j.jinorgbio.2023.112424. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurological disorder where one of the primary pathological hallmarks are aggregate deposits of the peptide amyloid-beta (Aβ). Although the Food and Drug Administration (FDA) has recently approved therapeutics that specifically target Aβ, resulting in the removal of these deposits, the associated costs of such treatments create a need for effective, yet cheaper, alternatives. Metal-based compounds are propitious therapeutic candidates as they exploit the metal-binding prope...
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Johanna T Ehlbeck Daniela M Grimard Ryan M Hacker Jimmy A Garcia Brendan J Wall Paige J Bothwell Marjorie A Jones Michael I Webb Source Type: research
Heme is pivotal for life
J Inorg Biochem. 2023 Oct 31:112423. doi: 10.1016/j.jinorgbio.2023.112423. Online ahead of print.NO ABSTRACTPMID:37953207 | DOI:10.1016/j.jinorgbio.2023.112423 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 12, 2023 Category: Biochemistry Authors: Massimo Coletta Martino Bolognesi Paolo Ascenzi Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
J Inorg Biochem. 2023 Oct 28;250:112421. doi: 10.1016/j.jinorgbio.2023.112421. Online ahead of print.ABSTRACTSix half-sandwich Ru(II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and spectroscopically characterized. The structure of Ru3 that crystallized as a monoclinic crystal with P21/c space group was further confirmed by X-ray single crystal diffraction. Prototropic tautomerism within the complexes transformed OH-form ligands to NH-form, forming a hydrogen bond (Cl1---H-N3). The complexes and ligands' cytotoxicity was assessed agains...
Source: Journal of Inorganic Biochemistry - November 3, 2023 Category: Biochemistry Authors: Yunhou Huang Shaoling Huang Wanxing Wei Yanchun Wu Limei Jia Yijia Du Peng Luo Weigao Pan Source Type: research
Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
J Inorg Biochem. 2023 Oct 24;250:112420. doi: 10.1016/j.jinorgbio.2023.112420. Online ahead of print.ABSTRACTTwo copper(I) polymorphs of formula [Cu(SALH)(TPP)3] (1a and 1b) were prepared by the conjugation of the Non-Steroidal Anti-Inflammatory Drug (NSAID) salicylic acid (SALH2) with the mitochondriotropic agent triphenylphosphine (TPP) via metal ion. For comparison, the isomorph [Ag(SALH)(TPP)3] (2) was prepared. The conjugates 1a, 1b and 2 were characterized by melting point (m.p.), Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy and nuclear magn...
Source: Journal of Inorganic Biochemistry - November 2, 2023 Category: Biochemistry Authors: Christina N Banti Angeliki A Piperoudi Catherine P Raptopoulou Vassilis Psycharis Constantinos M Athanassopoulos Sotiris K Hadjikakou Source Type: research
Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
J Inorg Biochem. 2023 Oct 24;250:112420. doi: 10.1016/j.jinorgbio.2023.112420. Online ahead of print.ABSTRACTTwo copper(I) polymorphs of formula [Cu(SALH)(TPP)3] (1a and 1b) were prepared by the conjugation of the Non-Steroidal Anti-Inflammatory Drug (NSAID) salicylic acid (SALH2) with the mitochondriotropic agent triphenylphosphine (TPP) via metal ion. For comparison, the isomorph [Ag(SALH)(TPP)3] (2) was prepared. The conjugates 1a, 1b and 2 were characterized by melting point (m.p.), Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy and nuclear magn...
Source: Journal of Inorganic Biochemistry - November 2, 2023 Category: Biochemistry Authors: Christina N Banti Angeliki A Piperoudi Catherine P Raptopoulou Vassilis Psycharis Constantinos M Athanassopoulos Sotiris K Hadjikakou Source Type: research
Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
J Inorg Biochem. 2023 Oct 24;250:112420. doi: 10.1016/j.jinorgbio.2023.112420. Online ahead of print.ABSTRACTTwo copper(I) polymorphs of formula [Cu(SALH)(TPP)3] (1a and 1b) were prepared by the conjugation of the Non-Steroidal Anti-Inflammatory Drug (NSAID) salicylic acid (SALH2) with the mitochondriotropic agent triphenylphosphine (TPP) via metal ion. For comparison, the isomorph [Ag(SALH)(TPP)3] (2) was prepared. The conjugates 1a, 1b and 2 were characterized by melting point (m.p.), Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy and nuclear magn...
Source: Journal of Inorganic Biochemistry - November 2, 2023 Category: Biochemistry Authors: Christina N Banti Angeliki A Piperoudi Catherine P Raptopoulou Vassilis Psycharis Constantinos M Athanassopoulos Sotiris K Hadjikakou Source Type: research
