Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells
J Inorg Biochem. 2024 Mar 6;254:112520. doi: 10.1016/j.jinorgbio.2024.112520. Online ahead of print.ABSTRACTThe antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain. This strategy allowed us to generate a titanium compound (Myr-Ti) capable of interacting with albumin, highly stable...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Sergio Gomez-Lopez Rosario Serrano Boiko Cohen Isabel Martinez-Argudo Laura Lopez-Sanz Marta Carmen Guadamillas Raul Calero Maria Jose Ruiz Source Type: research

Polypyridyl ruthenium complexes with benzothiazole moiety as membrane disruptors and anti-resistance agents for Staphylococcus aureus
In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, Ru-2 displayed remarkable inhibitory activity against Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. Additionally, it showcased low hemolytic toxicity (HC50 > 200 μg/mL) and the ability to effectively eradicate S. aureus without fostering drug resistance. Further investigation into the antibacterial mechanism suggested that Ru-2 may target the phospholipid component of S. aureus, leading to the disruption of the bacterial ce...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Wei Deng Chun-Yan Zhang Li-Xin Dou Li-Ting Huang Jin-Tiao Wang Xiang-Wen Liao Li-Ping Wang Ru-Jian Yu Yan-Shi Xiong Source Type: research

Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy
J Inorg Biochem. 2024 Mar 6;254:112518. doi: 10.1016/j.jinorgbio.2024.112518. Online ahead of print.ABSTRACTCisplatin is widely used as anticancer drugs, and DNA is considered as the main target. Considering its high affinity towards cysteines and the important role of cystine containing proteins, we applied a competitive activity-based protein profiling strategy to identify protein cysteines that bind with cisplatin in HeLa cells. Living cells were treated with cisplatin at cytotoxic concentrations, then the protein was extracted. After labeling with desthiobiotin iodoacetamide (DBIA) probe, protein was precipitated, dige...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Yi Chen Chenxi Wang Meiling Qi Yinyu Wei Hongliang Jiang Zhifeng Du Source Type: research

Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells
J Inorg Biochem. 2024 Mar 6;254:112520. doi: 10.1016/j.jinorgbio.2024.112520. Online ahead of print.ABSTRACTThe antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain. This strategy allowed us to generate a titanium compound (Myr-Ti) capable of interacting with albumin, highly stable...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Sergio Gomez-Lopez Rosario Serrano Boiko Cohen Isabel Martinez-Argudo Laura Lopez-Sanz Marta Carmen Guadamillas Raul Calero Maria Jose Ruiz Source Type: research

Polypyridyl ruthenium complexes with benzothiazole moiety as membrane disruptors and anti-resistance agents for Staphylococcus aureus
In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, Ru-2 displayed remarkable inhibitory activity against Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. Additionally, it showcased low hemolytic toxicity (HC50 > 200 μg/mL) and the ability to effectively eradicate S. aureus without fostering drug resistance. Further investigation into the antibacterial mechanism suggested that Ru-2 may target the phospholipid component of S. aureus, leading to the disruption of the bacterial ce...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Wei Deng Chun-Yan Zhang Li-Xin Dou Li-Ting Huang Jin-Tiao Wang Xiang-Wen Liao Li-Ping Wang Ru-Jian Yu Yan-Shi Xiong Source Type: research

Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy
J Inorg Biochem. 2024 Mar 6;254:112518. doi: 10.1016/j.jinorgbio.2024.112518. Online ahead of print.ABSTRACTCisplatin is widely used as anticancer drugs, and DNA is considered as the main target. Considering its high affinity towards cysteines and the important role of cystine containing proteins, we applied a competitive activity-based protein profiling strategy to identify protein cysteines that bind with cisplatin in HeLa cells. Living cells were treated with cisplatin at cytotoxic concentrations, then the protein was extracted. After labeling with desthiobiotin iodoacetamide (DBIA) probe, protein was precipitated, dige...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Yi Chen Chenxi Wang Meiling Qi Yinyu Wei Hongliang Jiang Zhifeng Du Source Type: research

Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells
J Inorg Biochem. 2024 Mar 6;254:112520. doi: 10.1016/j.jinorgbio.2024.112520. Online ahead of print.ABSTRACTThe antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain. This strategy allowed us to generate a titanium compound (Myr-Ti) capable of interacting with albumin, highly stable...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Sergio Gomez-Lopez Rosario Serrano Boiko Cohen Isabel Martinez-Argudo Laura Lopez-Sanz Marta Carmen Guadamillas Raul Calero Maria Jose Ruiz Source Type: research

Polypyridyl ruthenium complexes with benzothiazole moiety as membrane disruptors and anti-resistance agents for Staphylococcus aureus
In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, Ru-2 displayed remarkable inhibitory activity against Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. Additionally, it showcased low hemolytic toxicity (HC50 > 200 μg/mL) and the ability to effectively eradicate S. aureus without fostering drug resistance. Further investigation into the antibacterial mechanism suggested that Ru-2 may target the phospholipid component of S. aureus, leading to the disruption of the bacterial ce...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Wei Deng Chun-Yan Zhang Li-Xin Dou Li-Ting Huang Jin-Tiao Wang Xiang-Wen Liao Li-Ping Wang Ru-Jian Yu Yan-Shi Xiong Source Type: research

Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy
J Inorg Biochem. 2024 Mar 6;254:112518. doi: 10.1016/j.jinorgbio.2024.112518. Online ahead of print.ABSTRACTCisplatin is widely used as anticancer drugs, and DNA is considered as the main target. Considering its high affinity towards cysteines and the important role of cystine containing proteins, we applied a competitive activity-based protein profiling strategy to identify protein cysteines that bind with cisplatin in HeLa cells. Living cells were treated with cisplatin at cytotoxic concentrations, then the protein was extracted. After labeling with desthiobiotin iodoacetamide (DBIA) probe, protein was precipitated, dige...
Source: Journal of Inorganic Biochemistry - March 9, 2024 Category: Biochemistry Authors: Yi Chen Chenxi Wang Meiling Qi Yinyu Wei Hongliang Jiang Zhifeng Du Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research