Development of Cu(II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer

In this study, two novel Cu(II) complexes (Cu1 and Cu2) were designed and synthesized. Notably, these Cu(II) complexes showed higher cytotoxicity against HL-7402 cells than cisplatin. Moreover, Cu(II) complexes significantly inhibited liver cancer growth in a xenograft model. A mechanism study revealed that the Cu(II) complexes reduced the mitochondrial membrane potential of cancer cells, produced excessive reactive oxygen species (ROS), induced mitochondrial DNA (mtDNA) damage, and ultimately facilitated cancer cell apoptosis.PMID:38599004 | DOI:10.1016/j.jinorgbio.2024.112550

Source: Journal of Inorganic Biochemistry - April 10, 2024 Category: Biochemistry Authors: Ming Jiang Qiwei Yan Yuanping Fu Lili Meng Shuangshuang Gai Xiaohui Pan Yiming Qin Caiyun Jiang Source Type: research