Journal of Biological Inorganic Chemistry : JBIC This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Triggering antibacterial activity of a common plant by biosorption of selected heavy metals
J Biol Inorg Chem. 2024 Apr 8. doi: 10.1007/s00775-024-02045-1. Online ahead of print.ABSTRACTThe presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (qe = 12.66 and 53.13 mg g-1, respectively) was achieved afte...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 8, 2024 Category: Chemistry Authors: M ária Kováčová Halyna Bodn ár Yankovych Adrian Augustyniak Mariano Casas-Luna Michaela Reme šová Lenka Findor áková Martin Stahorsk ý Ladislav Čelko Matej Bal áž Source Type: research

Silver ciprofloxacin (CIPAG): a multitargeted metallodrug in the development of breast cancer therapy
J Biol Inorg Chem. 2024 Apr 6. doi: 10.1007/s00775-024-02048-y. Online ahead of print.ABSTRACTThe anti-proliferative activity of the known metalloantibiotic {[Ag(CIPH)2]NO3∙0.75MeOH∙1.2H2O} (CIPAG) (CIPH = ciprofloxacin) against the human breast adenocarcinoma cancer cells MCF-7 (hormone dependent (HD)) and MDA-MB-231 (hormone independent (HI)) is evaluated. The in vitro toxicity and genotoxicity of the metalloantibiotic were estimated toward fetal lung fibroblast (MRC-5) cells. The molecular mechanism of the CIPAG activity against MCF-7 cells was clarified by the (i) cell morphology, (ii) cell cycle arrest, (iii) mito...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 6, 2024 Category: Chemistry Authors: Christina N Banti Foteini D Kalousi Anna-Maria G Psarra Eleni E Moushi Demetres D Leonidas Sotiris K Hadjikakou Source Type: research

Probing calmodulin-NO synthase interactions via site-specific infrared spectroscopy: an introductory investigation
J Biol Inorg Chem. 2024 Apr 5. doi: 10.1007/s00775-024-02046-0. Online ahead of print.ABSTRACTCalmodulin (CaM) binds to a linker between the oxygenase and reductase domains of nitric oxide synthase (NOS) to regulate the functional conformational dynamics. Specific residues on the interdomain interface guide the domain-domain docking to facilitate the electron transfer in NOS. Notably, the docking interface between CaM and the heme-containing oxygenase domain of NOS is isoform specific, which is only beginning to be investigated. Toward advancing understanding of the distinct CaM-NOS docking interactions by infrared spectro...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 5, 2024 Category: Chemistry Authors: Swapnil Singh Yadav Prasad Gyawali Ting Jiang Gregory S Bukowski Huayu Zheng Haikun Zhang Rebecca Owopetu Megan C Thielges Changjian Feng Source Type: research

Collaborations in the Spanish-Speaking Bioinorganic Community
J Biol Inorg Chem. 2024 Mar 22. doi: 10.1007/s00775-024-02047-z. Online ahead of print.NO ABSTRACTPMID:38517517 | DOI:10.1007/s00775-024-02047-z (Source: Journal of Biological Inorganic Chemistry : JBIC)
Source: Journal of Biological Inorganic Chemistry : JBIC - March 22, 2024 Category: Chemistry Authors: Patrick Gamez Luis Lemus Source Type: research