Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 12. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechanisti...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research

How to and should we target EBV in MS?
Expert Rev Clin Immunol. 2024 Mar 15:1-12. doi: 10.1080/1744666X.2024.2328739. Online ahead of print.ABSTRACTINTRODUCTION: The etiology of multiple sclerosis (MS) remains unknown. Pathogenesis likely relies on a complex interaction between multiple environmental, genetic, and behavioral risk factors. However, a growing body of literature supports the role of a preceding Epstein-Barr virus (EBV) infection in the majority of cases.AREAS COVERED: In this narrative review, we summarize the latest findings regarding the potential role of EBV as a predisposing event inducing new onset of MS. EBV interactions with the genetic bac...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Svetlana Eckert Dejan Jakimovski Robert Zivadinov Mark Hicar Bianca Weinstock-Guttman Source Type: research

Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 12. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechanisti...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research

How to and should we target EBV in MS?
Expert Rev Clin Immunol. 2024 Mar 15:1-12. doi: 10.1080/1744666X.2024.2328739. Online ahead of print.ABSTRACTINTRODUCTION: The etiology of multiple sclerosis (MS) remains unknown. Pathogenesis likely relies on a complex interaction between multiple environmental, genetic, and behavioral risk factors. However, a growing body of literature supports the role of a preceding Epstein-Barr virus (EBV) infection in the majority of cases.AREAS COVERED: In this narrative review, we summarize the latest findings regarding the potential role of EBV as a predisposing event inducing new onset of MS. EBV interactions with the genetic bac...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Svetlana Eckert Dejan Jakimovski Robert Zivadinov Mark Hicar Bianca Weinstock-Guttman Source Type: research

Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 12. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechanisti...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research

How to and should we target EBV in MS?
Expert Rev Clin Immunol. 2024 Mar 15:1-12. doi: 10.1080/1744666X.2024.2328739. Online ahead of print.ABSTRACTINTRODUCTION: The etiology of multiple sclerosis (MS) remains unknown. Pathogenesis likely relies on a complex interaction between multiple environmental, genetic, and behavioral risk factors. However, a growing body of literature supports the role of a preceding Epstein-Barr virus (EBV) infection in the majority of cases.AREAS COVERED: In this narrative review, we summarize the latest findings regarding the potential role of EBV as a predisposing event inducing new onset of MS. EBV interactions with the genetic bac...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Svetlana Eckert Dejan Jakimovski Robert Zivadinov Mark Hicar Bianca Weinstock-Guttman Source Type: research

Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 12. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechanisti...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research

How to and should we target EBV in MS?
Expert Rev Clin Immunol. 2024 Mar 13. doi: 10.1080/1744666X.2024.2328739. Online ahead of print.ABSTRACTINTRODUCTION: The etiology of multiple sclerosis (MS) remains unknown. Pathogenesis likely relies on a complex interaction between multiple environmental, genetic, and behavioral risk factors. However, a growing body of literature supports the role of a preceding Epstein Barr Virus (EBV) infection in the majority of cases.AREAS COVERED: In this narrative review, we summarize the latest findings regarding the potential role of EBV as a predisposing event inducing new onset of MS. EBV interactions with the genetic backgrou...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Svetlana Eckert Dejan Jakimovski Robert Zivadinov Mark Hicar Bianca Weinstock-Guttman Source Type: research

Re-evaluation of nailfold capillaroscopy in discriminating primary from secondary Raynaud's phenomenon and in predicting systemic sclerosis: a randomised observational prospective cohort study
CONCLUSION: NFC patterns, believed as specific, showed low discriminatory power and on their own are unable to reliably discriminate sRP from pRP or predict evolution to SSc.PMID:38465507 | DOI:10.1080/1744666X.2024.2313642 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Marta C Amaral F Seguro Paula Joana Caetano Paul Rj Ames J Delgado Alves Source Type: research

Colorectal medullary carcinoma: a pathological subtype with intense immune response and potential to benefit from immune checkpoint inhibitors
Expert Rev Clin Immunol. 2024 Mar 8. doi: 10.1080/1744666X.2024.2328746. Online ahead of print.ABSTRACTINTRODUCTION: Different pathological types of colorectal cancer have distinguished immune landscape, and the efficacy of immunotherapy will be completely different. Colorectal medullary carcinoma, accounting for 2.2-3.2%, is characterized by massive lymphocyte infiltration. However, the attention to the immune characteristics of colorectal medullary carcinoma is insufficient.AREA COVERED: We searched the literature about colorectal medullary carcinoma on PubMed through November 2023to investigate the hallmarks of colorect...
Source: Expert Review of Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Haoyi Zou Chao Liu Yuli Ruan Lin Fang Tong Wu Shuling Han Tianjiao Dang Hongxue Meng Yanqiao Zhang Source Type: research

Immunobiology and treatment of cutaneous T-cell lymphoma
Expert Rev Clin Immunol. 2024 Mar 7:1-12. doi: 10.1080/1744666X.2024.2326035. Online ahead of print.ABSTRACTINTRODUCTION: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.AREAS COVERED: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.EXPERT OPINION: Recent advances in immunology have provided new insights int...
Source: Expert Review of Clinical Immunology - March 7, 2024 Category: Allergy & Immunology Authors: Rishi R Goel Alain H Rook Source Type: research