The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
Expert Rev Clin Immunol. 2021 Jun 9. doi: 10.1080/1744666X.2021.1940962. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier defects driving cutaneous inflammation and allergic symptomatology. The IL-4, IL-13, and IL-31 inflammatory pathways have been identified as hallmark features in the pathogenesis of the disease, contributing uniquely and synergistically to immune and barrier abnormalities as well as the key symptoms, such as pruritis. Novel therapeutics that t...
Source: Expert Review of Clinical Immunology - June 9, 2021 Category: Allergy & Immunology Authors: Celina Dubin Ester Del Duca Emma Guttman-Yassky Source Type: research

Association between genetic variants in < em > ZNF365 < /em > and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis
CONCLUSIONS: The meta-analysis demonstrated that the rs10761659 polymorphism might be a protective factor for both UC and CD in Caucasians, while the rs10995271 polymorphism might be a risk factor for UC rather than CD in Caucasians.PMID:34092165 | DOI:10.1080/1744666X.2021.1939012 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - June 7, 2021 Category: Allergy & Immunology Authors: Peng-Bo Wu Yu Zhang Gang Nie Xu Huang Yuan-Jie Yu An-Ning Yin Rui Zhou Chun-Ping He Peng Wang Source Type: research

Type I interferon detection in autoimmune diseases: challenges and clinical applications
Expert Rev Clin Immunol. 2021 Jun 7. doi: 10.1080/1744666X.2021.1939686. Online ahead of print.ABSTRACTINTRODUCTION: Accumulating data highlights that dysregulation of type I interferon (IFN) pathways plays a central role in the pathogenesis of several systemic and organ specific autoimmune diseases. Advances in understanding the role of type I IFNs in these disorders can lead to targeted drug development as well as establishing potential disease biomarkers.AREAS COVERED: Here, we summarize current knowledge regarding the role of type I IFNs in the major systemic, as well as organ specific, autoimmune disorders, including ...
Source: Expert Review of Clinical Immunology - June 7, 2021 Category: Allergy & Immunology Authors: Vassilis Papadopoulos Charalampos Skarlis Maria-Eleftheria Evangelopoulos Clio P Mavragani Source Type: research

Association between genetic variants in < em > ZNF365 < /em > and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis
CONCLUSIONS: The meta-analysis demonstrated that the rs10761659 polymorphism might be a protective factor for both UC and CD in Caucasians, while the rs10995271 polymorphism might be a risk factor for UC rather than CD in Caucasians.PMID:34092165 | DOI:10.1080/1744666X.2021.1939012 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - June 7, 2021 Category: Allergy & Immunology Authors: Peng-Bo Wu Yu Zhang Gang Nie Xu Huang Yuan-Jie Yu An-Ning Yin Rui Zhou Chun-Ping He Peng Wang Source Type: research

Type I interferon detection in autoimmune diseases: challenges and clinical applications
Expert Rev Clin Immunol. 2021 Jun 7. doi: 10.1080/1744666X.2021.1939686. Online ahead of print.ABSTRACTINTRODUCTION: Accumulating data highlights that dysregulation of type I interferon (IFN) pathways plays a central role in the pathogenesis of several systemic and organ specific autoimmune diseases. Advances in understanding the role of type I IFNs in these disorders can lead to targeted drug development as well as establishing potential disease biomarkers.AREAS COVERED: Here, we summarize current knowledge regarding the role of type I IFNs in the major systemic, as well as organ specific, autoimmune disorders, including ...
Source: Expert Review of Clinical Immunology - June 7, 2021 Category: Allergy & Immunology Authors: Vassilis Papadopoulos Charalampos Skarlis Maria-Eleftheria Evangelopoulos Clio P Mavragani Source Type: research

Association between genetic variants in < em > ZNF365 < /em > and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis
CONCLUSIONS: The meta-analysis demonstrated that the rs10761659 polymorphism might be a protective factor for both UC and CD in Caucasians, while the rs10995271 polymorphism might be a risk factor for UC rather than CD in Caucasians.PMID:34092165 | DOI:10.1080/1744666X.2021.1939012 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - June 7, 2021 Category: Allergy & Immunology Authors: Peng-Bo Wu Yu Zhang Gang Nie Xu Huang Yuan-Jie Yu An-Ning Yin Rui Zhou Chun-Ping He Peng Wang Source Type: research

Regulation of crystal induced inflammation: current understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 29. doi: 10.1080/1744666X.2021.1937129. Online ahead of print.ABSTRACTINTRODUCTION: Accumulation of abnormal crystals in the body, derived from endogenous or exogenous materials can drive a wide spectrum of inflammatory disease states. It is well established that intra-articular deposition of monosodium urate (MSU) and calcium pyrophoshate (CPP) crystals contribute to joint destruction through pro-inflammatory processes.AREAS COVERED: This review will focus on current understanding and recent novelty about the mechanisms and the clinical implications of the inflammation induced by MSU and...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Paola Galozzi Sara Bindoli Roberto Luisetto Paolo Sfriso Roberta Ramonda Anna Scanu Francesca Oliviero Source Type: research

The pathogenic oral-gut-liver axis: new understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 31. doi: 10.1080/1744666X.2021.1935877. Online ahead of print.ABSTRACTINTRODUCTION: : Oral health is closely related to extra-oral disease status, as may be represented by the manifestations of gastrointestinal and liver diseases.AREAS COVERED: : This review focuses on the roles that the oral-gut or the oral-gut-liver axis play in the pathogenesis of inflammatory bowel disease, colorectal cancer, metabolic fatty liver disease, and nonalcoholic steatohepatitis. The discussion will begin with clinical data, including data from preclinical animal models, to elucidate mechanisms. We will also ...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Jin Imai Sho Kitamoto Nobuhiko Kamada Source Type: research

Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF.METHODS: This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes.RESULTS: : LncRNA NEAT1 levels were higher in non-survivors than survivors (P
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Shuai Gao Yu-Chen Fan Li-Yan Han Kai Wang Source Type: research

Regulation of crystal induced inflammation: current understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 29. doi: 10.1080/1744666X.2021.1937129. Online ahead of print.ABSTRACTINTRODUCTION: Accumulation of abnormal crystals in the body, derived from endogenous or exogenous materials can drive a wide spectrum of inflammatory disease states. It is well established that intra-articular deposition of monosodium urate (MSU) and calcium pyrophoshate (CPP) crystals contribute to joint destruction through pro-inflammatory processes.AREAS COVERED: This review will focus on current understanding and recent novelty about the mechanisms and the clinical implications of the inflammation induced by MSU and...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Paola Galozzi Sara Bindoli Roberto Luisetto Paolo Sfriso Roberta Ramonda Anna Scanu Francesca Oliviero Source Type: research

The pathogenic oral-gut-liver axis: new understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 31. doi: 10.1080/1744666X.2021.1935877. Online ahead of print.ABSTRACTINTRODUCTION: : Oral health is closely related to extra-oral disease status, as may be represented by the manifestations of gastrointestinal and liver diseases.AREAS COVERED: : This review focuses on the roles that the oral-gut or the oral-gut-liver axis play in the pathogenesis of inflammatory bowel disease, colorectal cancer, metabolic fatty liver disease, and nonalcoholic steatohepatitis. The discussion will begin with clinical data, including data from preclinical animal models, to elucidate mechanisms. We will also ...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Jin Imai Sho Kitamoto Nobuhiko Kamada Source Type: research

Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF.METHODS: This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes.RESULTS: : LncRNA NEAT1 levels were higher in non-survivors than survivors (P
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Shuai Gao Yu-Chen Fan Li-Yan Han Kai Wang Source Type: research

Regulation of crystal induced inflammation: current understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 29. doi: 10.1080/1744666X.2021.1937129. Online ahead of print.ABSTRACTINTRODUCTION: Accumulation of abnormal crystals in the body, derived from endogenous or exogenous materials can drive a wide spectrum of inflammatory disease states. It is well established that intra-articular deposition of monosodium urate (MSU) and calcium pyrophoshate (CPP) crystals contribute to joint destruction through pro-inflammatory processes.AREAS COVERED: This review will focus on current understanding and recent novelty about the mechanisms and the clinical implications of the inflammation induced by MSU and...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Paola Galozzi Sara Bindoli Roberto Luisetto Paolo Sfriso Roberta Ramonda Anna Scanu Francesca Oliviero Source Type: research

The pathogenic oral-gut-liver axis: new understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 31. doi: 10.1080/1744666X.2021.1935877. Online ahead of print.ABSTRACTINTRODUCTION: : Oral health is closely related to extra-oral disease status, as may be represented by the manifestations of gastrointestinal and liver diseases.AREAS COVERED: : This review focuses on the roles that the oral-gut or the oral-gut-liver axis play in the pathogenesis of inflammatory bowel disease, colorectal cancer, metabolic fatty liver disease, and nonalcoholic steatohepatitis. The discussion will begin with clinical data, including data from preclinical animal models, to elucidate mechanisms. We will also ...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Jin Imai Sho Kitamoto Nobuhiko Kamada Source Type: research

Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF.METHODS: This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes.RESULTS: : LncRNA NEAT1 levels were higher in non-survivors than survivors (P
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Shuai Gao Yu-Chen Fan Li-Yan Han Kai Wang Source Type: research

Regulation of crystal induced inflammation: current understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 29. doi: 10.1080/1744666X.2021.1937129. Online ahead of print.ABSTRACTINTRODUCTION: Accumulation of abnormal crystals in the body, derived from endogenous or exogenous materials can drive a wide spectrum of inflammatory disease states. It is well established that intra-articular deposition of monosodium urate (MSU) and calcium pyrophoshate (CPP) crystals contribute to joint destruction through pro-inflammatory processes.AREAS COVERED: This review will focus on current understanding and recent novelty about the mechanisms and the clinical implications of the inflammation induced by MSU and...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Paola Galozzi Sara Bindoli Roberto Luisetto Paolo Sfriso Roberta Ramonda Anna Scanu Francesca Oliviero Source Type: research

The pathogenic oral-gut-liver axis: new understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 31. doi: 10.1080/1744666X.2021.1935877. Online ahead of print.ABSTRACTINTRODUCTION: : Oral health is closely related to extra-oral disease status, as may be represented by the manifestations of gastrointestinal and liver diseases.AREAS COVERED: : This review focuses on the roles that the oral-gut or the oral-gut-liver axis play in the pathogenesis of inflammatory bowel disease, colorectal cancer, metabolic fatty liver disease, and nonalcoholic steatohepatitis. The discussion will begin with clinical data, including data from preclinical animal models, to elucidate mechanisms. We will also ...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Jin Imai Sho Kitamoto Nobuhiko Kamada Source Type: research

Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF.METHODS: This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes.RESULTS: : LncRNA NEAT1 levels were higher in non-survivors than survivors (P
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Shuai Gao Yu-Chen Fan Li-Yan Han Kai Wang Source Type: research

Regulation of crystal induced inflammation: current understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 29. doi: 10.1080/1744666X.2021.1937129. Online ahead of print.ABSTRACTINTRODUCTION: Accumulation of abnormal crystals in the body, derived from endogenous or exogenous materials can drive a wide spectrum of inflammatory disease states. It is well established that intra-articular deposition of monosodium urate (MSU) and calcium pyrophoshate (CPP) crystals contribute to joint destruction through pro-inflammatory processes.AREAS COVERED: This review will focus on current understanding and recent novelty about the mechanisms and the clinical implications of the inflammation induced by MSU and...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Paola Galozzi Sara Bindoli Roberto Luisetto Paolo Sfriso Roberta Ramonda Anna Scanu Francesca Oliviero Source Type: research

The pathogenic oral-gut-liver axis: new understandings and clinical implications
Expert Rev Clin Immunol. 2021 May 31. doi: 10.1080/1744666X.2021.1935877. Online ahead of print.ABSTRACTINTRODUCTION: : Oral health is closely related to extra-oral disease status, as may be represented by the manifestations of gastrointestinal and liver diseases.AREAS COVERED: : This review focuses on the roles that the oral-gut or the oral-gut-liver axis play in the pathogenesis of inflammatory bowel disease, colorectal cancer, metabolic fatty liver disease, and nonalcoholic steatohepatitis. The discussion will begin with clinical data, including data from preclinical animal models, to elucidate mechanisms. We will also ...
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Jin Imai Sho Kitamoto Nobuhiko Kamada Source Type: research

Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF.METHODS: This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes.RESULTS: : LncRNA NEAT1 levels were higher in non-survivors than survivors (P
Source: Expert Review of Clinical Immunology - May 31, 2021 Category: Allergy & Immunology Authors: Shuai Gao Yu-Chen Fan Li-Yan Han Kai Wang Source Type: research

Genetic susceptibility to inflammatory bowel disease: should we be looking to the hypothalamus?
Expert Rev Clin Immunol. 2021 May 28:1-4. doi: 10.1080/1744666X.2021.1933443. Online ahead of print.NO ABSTRACTPMID:34047240 | DOI:10.1080/1744666X.2021.1933443 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 28, 2021 Category: Allergy & Immunology Authors: Arianna Dal Buono Daniela Caldirola Mariangela Allocca Source Type: research

Heterogeneity in myasthenia gravis: considerations for disease management
Expert Rev Clin Immunol. 2021 May 27. doi: 10.1080/1744666X.2021.1936500. Online ahead of print.ABSTRACTINTRODUCTION: Myasthenia gravis is a rare disease of the neuromuscular junction and a prototype of B cell driven immunopathology. Pathogenic antibodies target post-synaptic transmembrane proteins, most commonly the nicotinic acetylcholine receptor and the muscle-specific tyrosine kinase, inducing end-plate alterations and neuromuscular transmission impairment. Several clinical subtypes are distinct on the basis of associated antibodies, age at symptom onset, thymus pathology, genetic factors and weakness distribution. Th...
Source: Expert Review of Clinical Immunology - May 27, 2021 Category: Allergy & Immunology Authors: Amelia Evoli Gregorio Spagni Gabriele Monte Valentina Damato Source Type: research

SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives
Expert Rev Clin Immunol. 2021 May 20. doi: 10.1080/1744666X.2021.1932467. Online ahead of print.ABSTRACTINTRODUCTION: During the COVID-19 pandemic thyroid gland alteration/dysfunction has been emerged as a possible endocrine complication. The present review is focused on inflammatory and autoimmune thyroid complications triggered by SARS-CoV-2 infection by searching through databases like MEDLINE and Scopus up to April 2021.AREAS COVERED: Beside the occurrence of "non-thyroidal illness" in severe clinical conditions, alterations of thyroid function and structure may occur during COVID-19 as a consequence of eithe...
Source: Expert Review of Clinical Immunology - May 21, 2021 Category: Allergy & Immunology Authors: Rosaria M Ruggeri Alfredo Campenn ì Desiree Deandreis Massimiliano Siracusa Renato Tozzoli Petra Petranovi ć Ovčariček Luca Giovanella Source Type: research

Avacopan for the treatment of ANCA-associated vasculitis
Expert Rev Clin Immunol. 2021 May 19. doi: 10.1080/1744666X.2021.1932466. Online ahead of print.ABSTRACTINTRODUCTION: Anti-neutrophil cytoplasm autoantibodies (ANCA)-associated vasculitides (AAVs) are a group of rare heterogeneous diseases characterized by blood vessel inflammation resulting in organ destruction and death. Although various treatment strategies have resulted in marked improvement in vasculitis-specific outcomes, many patients with AAV continue to suffer from complications related to the prolonged use of glucocorticoids (GC) such as infections, metabolic abnormalities, and increased cardiovascular morbidity....
Source: Expert Review of Clinical Immunology - May 19, 2021 Category: Allergy & Immunology Authors: Mohammed Osman Jan Willem Cohen Tervaert Christian Pagnoux Source Type: research

The road to personalised medicine in psoriatic arthritis
Expert Rev Clin Immunol. 2021 May 18. doi: 10.1080/1744666X.2021.1931125. Online ahead of print.NO ABSTRACTPMID:34000952 | DOI:10.1080/1744666X.2021.1931125 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 18, 2021 Category: Allergy & Immunology Authors: JonathanPE White Laura C Coates Source Type: research

Clinical, Immunological, and Genetic Features in 938 Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED): a Systematic Review
CONCLUSION: Beside penetrance diversity, our review revealed a diverse affected ethnicity (mainly from Italy followed by Finland and Ireland). APECED can initially present in adolescence as 5.2% of the patients were older than 18 years at the disease onset. According to the variety of clinical conditions, which in the majority of patients appear gradually over time, clinical management deserves a separate analysis.PMID:33957837 | DOI:10.1080/1744666X.2021.1925543 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 7, 2021 Category: Allergy & Immunology Authors: Niusha Sharifinejad Majid Zaki-Dizaji Shafi Tebyanian Hamed Zainaldain Mahnaz Jamee Fatema Sadaat Rizvi Soheila Hosseinzadeh Farimah Fayyaz Haleh Hamedifar Araz Sabzevari Mojdeh Matloubi Edyta Heropolita ńska-Pliszka Fatemeh Aghamahdi Hassan Abolhassani Source Type: research

Antiphospholipid antibodies and osteonecrosis in systemic lupus erythematosus: a meta-analysis
CONCLUSION: : SLE patients demonstrated a weak association between aPLs and ON. The nature of the association between aPLs and ON in SLE needs to be investigated in-depth in future research.PMID:33956556 | DOI:10.1080/1744666X.2021.1925109 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 6, 2021 Category: Allergy & Immunology Authors: Wei Qijiao Zhou Meng Liu Jianwen Zhang Shengli None Gaofei Lin He Chen Zhihan Source Type: research