Immunology and targeted therapy in Castleman disease
Expert Rev Clin Immunol. 2024 May 24. doi: 10.1080/1744666X.2024.2357689. Online ahead of print.ABSTRACTINTRODUCTION: Castleman disease (CD) is a benign lymphoproliferative disease causing severe systemic inflammation. Interleukin-6 (IL-6) is a major pathogenesis of multicentric CD (MCD), but only 30-60% of patients respond to IL-6 inhibitors. Novel agents for IL-6 inhibitor-refractory cases are needed. Clinical data and samples are being collected on a large scale and the clinical, pathological and pathogenetic aspects are being elucidated.AREAS COVERED: The pathological and clinical classification of CD is outlined. Focu...
Source: Expert Review of Clinical Immunology - May 24, 2024 Category: Allergy & Immunology Authors: Shinichiro Tsunoda Takuya Harada Yoshikane Kikushige Tadamitsu Kishimoto Kazuyuki Yoshizaki Source Type: research

The effect of intense pulsed light combined with topical 0.05% cyclosporin a eyedrops in the treatment of Sj ögren's syndrome related dry eye
CONCLUSION: Treatment with 0.05% CsA eyedrops plus IPL therapy could significantly reduce the issues and physical discomfort of patients with SS-DE.CLINICAL TRIAL: Registered on 20 July 2021, with the registration number ChiCTR2100049059.PMID:38785065 | DOI:10.1080/1744666X.2024.2358157 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 24, 2024 Category: Allergy & Immunology Authors: Yanan Huo Xiaodan Huang Lin Lin Shuo Yang Zhenwei Qin Zhu Yirui Yujie Mou Xiuming Jin Source Type: research

Machine learning and artificial intelligence within pediatric autoimmune diseases: applications, challenges, future perspective
This study thoroughly explores the current knowledge and identifies the remaining gaps in the applications of machine learning specifically in the context of pediatric autoimmune and related diseases.EXPERT OPINION: Machine learning algorithms have the potential to completely change how pediatric autoimmune disorders are identified, treated, and managed. Machine learning can assist physicians in making more precise and fast judgments, identifying new biomarkers and therapeutic targets, and personalizing treatment strategies for each patient by utilizing massive datasets and powerful analytics.PMID:38771915 | DOI:10.1080/17...
Source: Expert Review of Clinical Immunology - May 21, 2024 Category: Allergy & Immunology Authors: Parniyan Sadeghi Hanie Karimi Atiye Lavafian Ronak Rashedi Noosha Samieefar Sajad Shafiekhani Nima Rezaei Source Type: research

Broadening the clinical spectrum of giant cell arteritis: from the classic cranial to the predominantly extracranial pattern of the disease
Expert Rev Clin Immunol. 2024 May 21:1-12. doi: 10.1080/1744666X.2024.2356741. Online ahead of print.ABSTRACTINTRODUCTION: Giant cell arteritis (GCA) is a large vessel (LV) vasculitis that affects people aged 50 years and older. Classically, GCA was considered a disease that involved branches of the carotid artery. However, the advent of new imaging techniques has allowed us to reconsider the clinical spectrum of this vasculitis.AREASCOVERED: This review describes clinical differences between patients with the cranial GCA and those with a predominantly extracranial LV-GCA disease pattern. It highlights differences in the f...
Source: Expert Review of Clinical Immunology - May 17, 2024 Category: Allergy & Immunology Authors: Miguel Ángel González-Gay Elena Heras-Recuero Teresa Bl ázquez-Sánchez Claritza Caraballo-Salazar Fernando Rengifo-Garc ía Santos Casta ñeda Raquel Largo Source Type: research

Broadening the clinical spectrum of giant cell arteritis: from the classic cranial to the predominantly extracranial pattern of the disease
Expert Rev Clin Immunol. 2024 May 17. doi: 10.1080/1744666X.2024.2356741. Online ahead of print.ABSTRACTINTRODUCTION: Giant cell arteritis (GCA) is a large vessel (LV) vasculitis thataffects people aged 50 years and older. Classically, GCA was considered adisease that involved branches of the carotid artery. However, the advent ofnew imaging techniques has allowed us to reconsider the clinical spectrum ofthis vasculitis.AREASCOVERED: The review describesclinical differences between patients with the cranial GCA and those with apredominantly extracranial LV-GCA disease pattern. It highlights differences inthe frequency of p...
Source: Expert Review of Clinical Immunology - May 17, 2024 Category: Allergy & Immunology Authors: Miguel Ángel González-Gay Elena Heras-Recuero Teresa Bl ázquez-Sánchez Claritza Caraballo-Salazar Fernando Rengifo-Garc ía Santos Casta ñeda Raquel Largo Source Type: research

CSE1L as a prognostic biomarker associated with pan cancer immune infiltration and drug sensitivity
CONCLUSION: Our findings demonstrate that CSE1L promotes tumor development in various malignancies, highlighting its potential as both a therapeutic target and prognostic indicator.PMID:38752776 | DOI:10.1080/1744666X.2024.2356747 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 16, 2024 Category: Allergy & Immunology Authors: Haiyang Li Lingwa Wang Zhaohui Ruan Xiaoyan Li Yifan Yang Jugao Fang Ru Wang Source Type: research

Updating on pregnancy in Rheumatoid Arthritis
Expert Rev Clin Immunol. 2024 May 15. doi: 10.1080/1744666X.2024.2356164. Online ahead of print.ABSTRACTINTRODUCTION: Rheumatoid arthritis (RA), the most prevalent autoimmune disease in reproductive years, exhibits a higher incidence in females, suggesting involvement of estrogens, genetics and environmental factors in disease onset. Literature shows smaller families in RA patients, driving increased interest in Assisted Reproductive Techniques.AREAS COVERED: This review elucidates how immunotolerance mechanisms contribute to favorable pregnancy outcomes in RA, emphasizing the need for a careful pregnancy planning to mitig...
Source: Expert Review of Clinical Immunology - May 15, 2024 Category: Allergy & Immunology Authors: Carlotta Schenone Greta Pacini Emanuele Gotelli Elvis Hysa Rosanna Campitiello Silvia Sammor ì Sabrina Paolino Alberto Sulli Maurizio Cutolo Source Type: research

Overcoming the challenges of primary resistance and relapse after CAR-T cell therapy
Expert Rev Clin Immunol. 2024 May 14:1-19. doi: 10.1080/1744666X.2024.2349738. Online ahead of print.ABSTRACTINTRODUCTION: While CAR T-cell therapy has led to remarkable responses in relapsed B-cell hematologic malignancies, only 50% of patients ultimately have a complete, sustained response. Understanding the mechanisms of resistance and relapse after CAR T-cell therapy is crucial to future development and improving outcomes.AREAS COVERED: We review reasons for both primary resistance and relapse after CAR T-cell therapies. Reasons for primary failure include CAR T-cell manufacturing problems, suboptimal fitness of autolo...
Source: Expert Review of Clinical Immunology - May 13, 2024 Category: Allergy & Immunology Authors: Alexandra Dreyzin Alexander W Rankin Katia Luciani Tatyana Gavrilova Nirali N Shah Source Type: research

Overcoming the challenges of primary resistance and relapse after CAR-T cell therapy
Expert Rev Clin Immunol. 2024 May 13. doi: 10.1080/1744666X.2024.2349738. Online ahead of print.ABSTRACTINTRODUCTION: While CAR T-cell therapy has led to remarkable responses in relapsed B-cell hematologic malignancies, only 50% of patients ultimately have a complete, sustained response. Understanding the mechanisms of resistance and relapse after CAR T-cell therapy is crucial to future development and improving outcomes.AREAS COVERED: We review reasons for both primary resistance and relapse after CAR T-cell therapies. Reasons for primary failure include CAR T-cell manufacturing problems, suboptimal fitness of autologous ...
Source: Expert Review of Clinical Immunology - May 13, 2024 Category: Allergy & Immunology Authors: Alexandra Dreyzin Alexander W Rankin Katia Luciani Tatyana Gavrilova Nirali N Shah Source Type: research

Navigating the crossroads: asthma, trained immunity, and infection susceptibility
Expert Rev Clin Immunol. 2024 May 9:1-3. doi: 10.1080/1744666X.2024.2353743. Online ahead of print.NO ABSTRACTPMID:38716705 | DOI:10.1080/1744666X.2024.2353743 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 8, 2024 Category: Allergy & Immunology Authors: Ahmad Z Al Meslamani Eman Merghani Ali Source Type: research