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Combination biologics or targeted synthetic disease-modifying anti-rheumatic drugs in the treatment of spondyloarthritis: a systematic literature review
CONCLUSIONS: There is not enough data to fully evaluate efficacy and safety of combination b/tsDMARDs in SpA treatment. Limited information shows apremilast plus bDMARD, or TNF inhibitor plus IL12/23 inhibitor combination to be efficacious and safe. Randomized controlled trials and larger cohort with a longer follow-up are required.PMID:38512065 | DOI:10.1080/1744666X.2024.2327589 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Rand Abedalweli Michelle Nguyen Atul Deodhar Source Type: research

What is the relevance of FoxP3 in the tumor microenvironment and cancer outcomes?
Expert Rev Clin Immunol. 2024 Mar 21. doi: 10.1080/1744666X.2024.2334258. Online ahead of print.ABSTRACTINTRODUCTION: Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradicto...
Source: Expert Review of Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Abdo Meyiah Eyad Elkord Source Type: research

Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 21:1-8. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechan...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research

How to and should we target EBV in MS?
Expert Rev Clin Immunol. 2024 Mar 15:1-12. doi: 10.1080/1744666X.2024.2328739. Online ahead of print.ABSTRACTINTRODUCTION: The etiology of multiple sclerosis (MS) remains unknown. Pathogenesis likely relies on a complex interaction between multiple environmental, genetic, and behavioral risk factors. However, a growing body of literature supports the role of a preceding Epstein-Barr virus (EBV) infection in the majority of cases.AREAS COVERED: In this narrative review, we summarize the latest findings regarding the potential role of EBV as a predisposing event inducing new onset of MS. EBV interactions with the genetic bac...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Svetlana Eckert Dejan Jakimovski Robert Zivadinov Mark Hicar Bianca Weinstock-Guttman Source Type: research

Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Expert Rev Clin Immunol. 2024 Mar 12. doi: 10.1080/1744666X.2024.2330604. Online ahead of print.ABSTRACTINTRODUCTION: Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients.AREAS COVERED: This review is designed to cover the recent progress in mechanisti...
Source: Expert Review of Clinical Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Jie Wang Bo Yang Jyotsna Chandra Andrei Ivanov J Mark Brown Florian Rieder Source Type: research