Expert Review of Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Biologics for hidradenitis suppurativa: evolution of the treatment paradigm
Expert Rev Clin Immunol. 2023 Dec 22. doi: 10.1080/1744666X.2023.2298356. Online ahead of print.ABSTRACTINTRODUCTION: Hidradenitis suppurativa (HS) is an autoinflammatory skin disease with a high unmet need for effective medical management. Clinically, it is characterized by inflammatory nodules that may progress into abscesses, draining tunnels and extensive scarring, mainly affecting apocrine gland-bearing areas. Although its pathophysiology is still incompletely understood, high levels of Interleukin (IL)-1/17/23 and Tumor Necrosis Factor (TNF)-α have been demonstrated.AREAS COVERED: Treatment options include topical, ...
Source: Expert Review of Clinical Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Carlo Alberto Maronese Chiara Moltrasio Giovanni Genovese Angelo Valerio Marzano Source Type: research

The clinical role of Anakinra in the armamentarium against familial mediterranean fever
Expert Rev Clin Immunol. 2023 Dec 22. doi: 10.1080/1744666X.2023.2299230. Online ahead of print.ABSTRACTINTRODUCTION: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease that has mainly been treated with colchicine since 1972. A significant portion of patients do not respond to colchicine and require further treatment, mainly IL-1β antagonists such as anakinra, canakinumab and rilonacept as IL-1β has a crucial role in pathogenesis of FMF. This review summarizes the current approach to treating FMF and discovers the pharmacological and clinical utility of IL-1 blocking agents based on accumulate...
Source: Expert Review of Clinical Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Kerem Parlar Muhammed Bahaddin Ates Bugra Han Egeli Serdal Ugurlu Source Type: research

Tapinarof cream for the topical treatment of plaque psoriasis in adults
Expert Rev Clin Immunol. 2023 Dec 20:1-11. doi: 10.1080/1744666X.2023.2296607. Online ahead of print.ABSTRACTINTRODUCTION: Plaque psoriasis, a chronic immune-mediated skin disorder, is characterized by well-demarcated erythematous plaques with silvery scales. This condition stems from complex interactions between genetic predisposition, immune dysregulation, and environmental triggers. Tapinarof downregulates the cytokine IL-17, diminishes the inflammatory infiltrate, and provides antioxidant properties while enhancing the expression of skin barrier proteins.AREAS COVERED: This review begins by assessing tapinarof's mechan...
Source: Expert Review of Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Kaley Prieto Jessica Q Duong Steven R Feldman Source Type: research

Balancing risks and benefits in the use of hydroxychloroquine and glucocorticoids in systemic lupus erythematosus
Expert Rev Clin Immunol. 2023 Dec 19. doi: 10.1080/1744666X.2023.2294938. Online ahead of print.ABSTRACTINTRODUCTION: Hydroxychloroquine (HCQ) and glucocorticoids (GCs) constitute the oldest and more used drugs in the treatment of systemic lupus erythematosus (SLE). Despite this long experience, both are still subject to a number of uncertainties regarding the dose.AREAS COVERED: We review the main mechanisms of action, the clinical and toxic effects of HCQ and GCs and analyze the recommendations for the use of both in guidelines published since 2018. We offer a set of recommendations based on the pharmacology, mechanisms ...
Source: Expert Review of Clinical Immunology - December 19, 2023 Category: Allergy & Immunology Authors: Diana Paredes-Ruiz Daniel Mart ín-Iglesias Guillermo Ruiz-Irastorza Source Type: research

A successful linkage of a named patient products of sublingual immunotherapy-dispensing registry to French healthcare insurance database (SNDS): methodological constitution of the EfficAPSI cohort
CONCLUSIONS: To date, the EfficAPSI cohort has the largest number of person-years of follow-up in the field of AIT. The completeness of the data allows to evaluate SLIT liquid effectiveness with rigorous methodology, leading to important insights on personalized medicine in real-life.PMID:38112340 | DOI:10.1080/1744666X.2023.2294040 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - December 19, 2023 Category: Allergy & Immunology Authors: Philippe Devillier Mathieu Molimard Jean-Fran çois Bergmann Bertrand Delaisi Amandine Gouverneur Jade Vadel C édric Collin Laurence Girard Silvia Scurati Pascal Demoly Source Type: research

The complex relationship between large granular lymphocyte leukemia and rheumatic disease
Expert Rev Clin Immunol. 2023 Dec 18:1-13. doi: 10.1080/1744666X.2023.2292758. Online ahead of print.ABSTRACTINTRODUCTION: Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder characterized by an expansion of clonal T or NK lymphocytes. Neutropenia-related infections represent the main clinical manifestation. Even if the disease follows an indolent course, most patients will ultimately need treatment in their lifetime. Interestingly, LGL leukemia is characterized by a high frequency of autoimmune disorders with rheumatoid arthritis being the most frequent.AREAS COVERED: This review covers the pa...
Source: Expert Review of Clinical Immunology - December 18, 2023 Category: Allergy & Immunology Authors: Tony Marchand Thierry Lamy Source Type: research

Causal role of immune cells in chronic obstructive pulmonary disease: mendelian randomization study
CONCLUSION: This study found a potential causal relationship between immune cells in COPD, ruling out reverse causation. This study provides new avenues for studying the mechanisms of COPD.PMID:38108202 | DOI:10.1080/1744666X.2023.2295987 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - December 18, 2023 Category: Allergy & Immunology Authors: Bi Ran Jiangyue Qin Yanqiu Wu Fuqiang Wen Source Type: research

Managing acute COVID-19 in immunocompromised pediatric patients
Expert Rev Clin Immunol. 2023 Dec 15. doi: 10.1080/1744666X.2023.2295982. Online ahead of print.ABSTRACTINTRODUCTION: SARS-CoV-2 infection is a potentially life-threatening infection in immunocompromised pediatric patients and its management has rapidly evolved during the pandemic. For the control of SARS-CoV-2 infection, over time, the scenario changed for the better with the introduction of specific treatments such as antiviral drugs, vaccines and monoclonal antibodies together with drugs blocking the inflammatory cytokine cascade and improvements of supportive care.AREAS COVERED: the paper discusses the therapeutic stra...
Source: Expert Review of Clinical Immunology - December 15, 2023 Category: Allergy & Immunology Authors: Federico Mercolini Nicoletta Abram Simone Cesaro Source Type: research