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Managing gastrointestinal manifestations in systemic sclerosis, a mechanistic approach
Expert Rev Clin Immunol. 2024 Feb 26:1-20. doi: 10.1080/1744666X.2024.2320205. Online ahead of print.ABSTRACTINTRODUCTION: Systemic sclerosis (SSc) is a connective tissue disease with heterogeneous presentation. Gastrointestinal (GI) complications of SSc are characterized by esophageal reflux, abnormal motility, and microbiome dysbiosis, which impact patient quality of life and mortality. Preventative therapeutics are lacking, with management primarily aimed at symptomatic control.AREAS COVERED: A broad literature review was conducted through electronic databases and references from key articles. We summarize the physiolog...
Source: Expert Review of Clinical Immunology - February 26, 2024 Category: Allergy & Immunology Authors: Timothy Kaniecki Michael Hughes Zsuzsanna McMahan Source Type: research

Rheumatic adverse events of immune checkpoint inhibitors in cancer immunotherapy
Expert Rev Clin Immunol. 2024 Feb 24. doi: 10.1080/1744666X.2024.2323966. Online ahead of print.ABSTRACTINTRODUCTION: The advent of immune checkpoint inhibitors (ICIs) in cancer treatment has marked a transformative era, albeit tempered by immune-related adverse events (irAEs), including those impacting the musculoskeletal system. The lack of precise epidemiologic data on rheumatic irAEs is attributed to factors such as potential underrecognition, underreporting in clinical trials, and the tendency to overlook manifestations without immediate life-threatening implications, further complicating the determination of accurate...
Source: Expert Review of Clinical Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Noha Abdel-Wahab Maria E Suarez-Almazor Source Type: research

Recent insights into extracorporeal photopheresis for graft-versus-host disease
Expert Rev Clin Immunol. 2024 Feb 20:1-10. doi: 10.1080/1744666X.2023.2295405. Online ahead of print.ABSTRACTINTRODUCTION: Extracorporeal Photopheresis (ECP) may be considered the unique large-scale cell therapy currently available. It is currently employed mainly as second-line treatment, especially in steroid-resistant or steroid-dependent Graft versus Host Disease (GvHD) with good results and very few limitations.AREAS COVERED: Many points need to be clarified regarding the ECP mechanism of action, that conditions the lack of uniqueness among the different centers, essentially cycle frequency, treatment duration, and th...
Source: Expert Review of Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Claudia Del Fante Cesare Perotti Source Type: research

Sparsentan: the first and only non-immunosuppressive therapy for the reduction of proteinuria in IgA nephropathy
Expert Rev Clin Immunol. 2024 Feb 16. doi: 10.1080/1744666X.2024.2319132. Online ahead of print.ABSTRACTINTRODUCTION: IgA nephropathy is one of the most common forms of glomerular disease. Patients with persistent proteinuria are at increased risk of progression to kidney failure. There is a significant need for safe and effective therapies to lower proteinuria in these patients. Sparsentan is a non-immunosuppressive agent that acts as a dual angiotensin and endothelin receptor antagonist. It lowers proteinuria in experimental models of glomerular disease and in affected patients.AREAS COVERED: This review covers the immun...
Source: Expert Review of Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Howard Trachtman Radko Komers Jula Inrig Source Type: research