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Colorectal medullary carcinoma: a pathological subtype with intense immune response and potential to benefit from immune checkpoint inhibitors
Expert Rev Clin Immunol. 2024 Mar 8. doi: 10.1080/1744666X.2024.2328746. Online ahead of print.ABSTRACTINTRODUCTION: Different pathological types of colorectal cancer have distinguished immune landscape, and the efficacy of immunotherapy will be completely different. Colorectal medullary carcinoma, accounting for 2.2-3.2%, is characterized by massive lymphocyte infiltration. However, the attention to the immune characteristics of colorectal medullary carcinoma is insufficient.AREA COVERED: We searched the literature about colorectal medullary carcinoma on PubMed through November 2023to investigate the hallmarks of colorect...
Source: Expert Review of Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Haoyi Zou Chao Liu Yuli Ruan Lin Fang Tong Wu Shuling Han Tianjiao Dang Hongxue Meng Yanqiao Zhang Source Type: research

Immunobiology and treatment of cutaneous T-cell lymphoma
Expert Rev Clin Immunol. 2024 Mar 7:1-12. doi: 10.1080/1744666X.2024.2326035. Online ahead of print.ABSTRACTINTRODUCTION: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.AREAS COVERED: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.EXPERT OPINION: Recent advances in immunology have provided new insights int...
Source: Expert Review of Clinical Immunology - March 7, 2024 Category: Allergy & Immunology Authors: Rishi R Goel Alain H Rook Source Type: research

Treatment strategies for ANCA-associated vasculitides: from standard protocols to future horizons
Expert Rev Clin Immunol. 2024 Mar 6:1-16. doi: 10.1080/1744666X.2024.2326628. Online ahead of print.ABSTRACTINTRODUCTION: ANCA-associated vasculitides (AAV), classified into granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis represent a group of disorders characterized by necrotizing vasculitis of small vessels, endothelial injury and tissue damage. The outcomes and prognosis of AAV have undergone significant changes with the introduction of glucocorticoids (GCs) and other immunosuppressants (cyclophosphamide, azathioprine, methotrexate, and mycophenolate mofetil)....
Source: Expert Review of Clinical Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Francesco Reggiani Matteo Stella Marta Calatroni Renato Alberto Sinico Source Type: research

Antiphospholipid antibodies and the risk of adverse pregnancy outcomes in patients with systemic lupus erythematosus: a systematic review and meta-analysis
CONCLUSIONS: Both, LA and aCL were risk factors of APOs in patients with SLE. Not only ACL, particularly aCL-IgM, but antiβ2GP1 were associated with an increased risk of fetal loss, while LA appeared to indicate the risk of preterm birth.PROSPERO (CRD42023388122).PMID:38445835 | DOI:10.1080/1744666X.2024.2324005 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Jinge Huang Qingmiao Zhu Baizhou Wang Hanzheng Wang Zhijun Xie Xingyu Zhu Ting Zhao Zi Yang Source Type: research

Atopic dermatitis stratification: current and future perspective on skin and blood transcriptomic and proteomic profiling
Expert Rev Clin Immunol. 2024 Mar 4:1-6. doi: 10.1080/1744666X.2024.2323964. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis (AD) is a common, chronic inflammatory skin disorder driven by an intricate interplay of genetic, environmental, and immunological factors.AREAS COVERED: As a clinically heterogenous condition, AD may be stratified into subtypes based on factors including, chronicity, immunoglobulin E levels, severity, age, and ethnicity. Transcriptomic and proteomic analyses in skin and blood help elucidate the underlying molecular mechanisms of these AD subtypes, referred to as AD endotypes. Further c...
Source: Expert Review of Clinical Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kelly Hawkins Eden David Jacob W Glickman Ester Del Duca Emma Guttman-Yassky James G Krueger Source Type: research

Managing gastrointestinal manifestations in systemic sclerosis, a mechanistic approach
Expert Rev Clin Immunol. 2024 Feb 26:1-20. doi: 10.1080/1744666X.2024.2320205. Online ahead of print.ABSTRACTINTRODUCTION: Systemic sclerosis (SSc) is a connective tissue disease with heterogeneous presentation. Gastrointestinal (GI) complications of SSc are characterized by esophageal reflux, abnormal motility, and microbiome dysbiosis, which impact patient quality of life and mortality. Preventative therapeutics are lacking, with management primarily aimed at symptomatic control.AREAS COVERED: A broad literature review was conducted through electronic databases and references from key articles. We summarize the physiolog...
Source: Expert Review of Clinical Immunology - February 26, 2024 Category: Allergy & Immunology Authors: Timothy Kaniecki Michael Hughes Zsuzsanna McMahan Source Type: research