Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway
In conclusion, the inhibitory effects of PFTeDA on pubertal rat Leydig cell development are possibly regulated by inducing ferroptosis thereby downregulating SIRT1/AMPKA/ autophagy pathways, eventually resulting in reduced steroidogenesis.PMID:37269911 | DOI:10.1016/j.toxlet.2023.05.012 (Source: Toxicology Letters)
Source: Toxicology Letters - June 3, 2023 Category: Toxicology Authors: Yunbing Tang Shi Lei Shaowei Wang Han Lu Huitao Li Jieqiang Lv Ren-Shan Ge Yingfen Ying Source Type: research
Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway
In conclusion, the inhibitory effects of PFTeDA on pubertal rat Leydig cell development are possibly regulated by inducing ferroptosis thereby downregulating SIRT1/AMPKA/ autophagy pathways, eventually resulting in reduced steroidogenesis.PMID:37269911 | DOI:10.1016/j.toxlet.2023.05.012 (Source: Toxicology Letters)
Source: Toxicology Letters - June 3, 2023 Category: Toxicology Authors: Yunbing Tang Shi Lei Shaowei Wang Han Lu Huitao Li Jieqiang Lv Ren-Shan Ge Yingfen Ying Source Type: research
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar- γ pathway
Toxicol Lett. 2023 May 26;382:33-40. doi: 10.1016/j.toxlet.2023.05.009. Online ahead of print.ABSTRACTBenzene is a known hematotoxic and leukemogenic chemical. Exposure to benzene cause inhibition of hematopoietic cells. However, the mechanism of how the hematopoietic cells inhibited by benzene undergo malignant proliferation is unknown. The cells carrying leukemia-associated fusion genes are present in healthy individuals and predispose the carriers to the development of leukemia. To identify the effects of benzene on hematopoietic cells, preleukemic bone marrow (PBM) cells derived from transgenic mice carrying the Mll-Af...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Yedan Lu Pinpin Sui Jinzhe Li Nan Lian Jin Zhou Xiurong Cheng Qian-Fei Wang Caihong Xing Peiyu Xu Source Type: research
A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
Toxicol Lett. 2023 May 26;382:41-46. doi: 10.1016/j.toxlet.2023.05.010. Online ahead of print.ABSTRACTIsolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle contraction by opioids. In the present study, we set out to establish a pharmacologically stimulated rat bowel model. The effects of carfentanil, remifentanil and the new synthetic opioid U-48800 and their respective antagonists naloxone, nalmefene and naltrexone were studied in a small bowel model in rats. The IC50 values of the tested opioids were as follows: carfe...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Niko Amend Horst Thiermann Franz Worek Timo Wille Source Type: research
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar- γ pathway
Toxicol Lett. 2023 May 26;382:33-40. doi: 10.1016/j.toxlet.2023.05.009. Online ahead of print.ABSTRACTBenzene is a known hematotoxic and leukemogenic chemical. Exposure to benzene cause inhibition of hematopoietic cells. However, the mechanism of how the hematopoietic cells inhibited by benzene undergo malignant proliferation is unknown. The cells carrying leukemia-associated fusion genes are present in healthy individuals and predispose the carriers to the development of leukemia. To identify the effects of benzene on hematopoietic cells, preleukemic bone marrow (PBM) cells derived from transgenic mice carrying the Mll-Af...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Yedan Lu Pinpin Sui Jinzhe Li Nan Lian Jin Zhou Xiurong Cheng Qian-Fei Wang Caihong Xing Peiyu Xu Source Type: research
A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
Toxicol Lett. 2023 May 26:S0378-4274(23)00187-X. doi: 10.1016/j.toxlet.2023.05.010. Online ahead of print.ABSTRACTIsolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle contraction by opioids. In the present study, we set out to establish a pharmacologically stimulated rat bowel model. The effects of carfentanil, remifentanil and the new synthetic opioid U-48800 and their respective antagonists naloxone, nalmefene and naltrexone were studied in a small bowel model in rats. The IC50 values of the tested opioids were as fo...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Niko Amend Horst Thiermann Franz Worek Timo Wille Source Type: research
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar- γ pathway
Toxicol Lett. 2023 May 26;382:33-40. doi: 10.1016/j.toxlet.2023.05.009. Online ahead of print.ABSTRACTBenzene is a known hematotoxic and leukemogenic chemical. Exposure to benzene cause inhibition of hematopoietic cells. However, the mechanism of how the hematopoietic cells inhibited by benzene undergo malignant proliferation is unknown. The cells carrying leukemia-associated fusion genes are present in healthy individuals and predispose the carriers to the development of leukemia. To identify the effects of benzene on hematopoietic cells, preleukemic bone marrow (PBM) cells derived from transgenic mice carrying the Mll-Af...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Yedan Lu Pinpin Sui Jinzhe Li Nan Lian Jin Zhou Xiurong Cheng Qian-Fei Wang Caihong Xing Peiyu Xu Source Type: research
A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
Toxicol Lett. 2023 May 26:S0378-4274(23)00187-X. doi: 10.1016/j.toxlet.2023.05.010. Online ahead of print.ABSTRACTIsolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle contraction by opioids. In the present study, we set out to establish a pharmacologically stimulated rat bowel model. The effects of carfentanil, remifentanil and the new synthetic opioid U-48800 and their respective antagonists naloxone, nalmefene and naltrexone were studied in a small bowel model in rats. The IC50 values of the tested opioids were as fo...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Niko Amend Horst Thiermann Franz Worek Timo Wille Source Type: research
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar- γ pathway
Toxicol Lett. 2023 May 26:S0378-4274(23)00183-2. doi: 10.1016/j.toxlet.2023.05.009. Online ahead of print.ABSTRACTBenzene is a known hematotoxic and leukemogenic chemical. Exposure to benzene cause inhibition of hematopoietic cells. However, the mechanism of how the hematopoietic cells inhibited by benzene undergo malignant proliferation is unknown. The cells carrying leukemia-associated fusion genes are present in healthy individuals and predispose the carriers to the development of leukemia. To identify the effects of benzene on hematopoietic cells, preleukemic bone marrow (PBM) cells derived from transgenic mice carryin...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Yedan Lu Pinpin Sui Jinzhe Li Nan Lian Jin Zhou Xiurong Cheng Qian-Fei Wang Caihong Xing Peiyu Xu Source Type: research
A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
Toxicol Lett. 2023 May 26:S0378-4274(23)00187-X. doi: 10.1016/j.toxlet.2023.05.010. Online ahead of print.ABSTRACTIsolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle contraction by opioids. In the present study, we set out to establish a pharmacologically stimulated rat bowel model. The effects of carfentanil, remifentanil and the new synthetic opioid U-48800 and their respective antagonists naloxone, nalmefene and naltrexone were studied in a small bowel model in rats. The IC50 values of the tested opioids were as fo...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Niko Amend Horst Thiermann Franz Worek Timo Wille Source Type: research
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar- γ pathway
Toxicol Lett. 2023 May 26:S0378-4274(23)00183-2. doi: 10.1016/j.toxlet.2023.05.009. Online ahead of print.ABSTRACTBenzene is a known hematotoxic and leukemogenic chemical. Exposure to benzene cause inhibition of hematopoietic cells. However, the mechanism of how the hematopoietic cells inhibited by benzene undergo malignant proliferation is unknown. The cells carrying leukemia-associated fusion genes are present in healthy individuals and predispose the carriers to the development of leukemia. To identify the effects of benzene on hematopoietic cells, preleukemic bone marrow (PBM) cells derived from transgenic mice carryin...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Yedan Lu Pinpin Sui Jinzhe Li Nan Lian Jin Zhou Xiurong Cheng Qian-Fei Wang Caihong Xing Peiyu Xu Source Type: research
A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
Toxicol Lett. 2023 May 26:S0378-4274(23)00187-X. doi: 10.1016/j.toxlet.2023.05.010. Online ahead of print.ABSTRACTIsolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle contraction by opioids. In the present study, we set out to establish a pharmacologically stimulated rat bowel model. The effects of carfentanil, remifentanil and the new synthetic opioid U-48800 and their respective antagonists naloxone, nalmefene and naltrexone were studied in a small bowel model in rats. The IC50 values of the tested opioids were as fo...
Source: Toxicology Letters - May 28, 2023 Category: Toxicology Authors: Niko Amend Horst Thiermann Franz Worek Timo Wille Source Type: research
Long-term Effects of Prenatal Arsenic Exposure from Gestational Day 9 to Birth on Lung, Heart, and Immune Outcomes in the C57BL/6 Mouse Model
This study aimed to characterize the long-term impact of mid-pregnancy inorganic arsenic exposure on the lung, heart, and immune system, including infectious disease response using the C57BL/6 mouse model. Mice were exposed from gestational day 9 till birth to either 0 or 1000µg/L sodium (meta)arsenite in drinking water. Male and female offspring assessed at adulthood (10-12 weeks of age) did not show significant effects on recovery outcomes after ischemia reperfusion injury but did exhibit increased airway hyperresponsiveness compared to controls. Flow cytometric analysis revealed significantly greater total numbers of c...
Source: Toxicology Letters - May 27, 2023 Category: Toxicology Authors: Kristal A Rychlik Emily J Illingworth Ian F Sanchez Sarah E Attreed Prithvi Sinha Kevin M Casin Nicole Taube Jeff Loube Rokeya Tasneen Raihan Kabir Eric Nuermberger Wayne Mitzner Mark J Kohr Fenna C M Sill é Source Type: research
Long-term Effects of Prenatal Arsenic Exposure from Gestational Day 9 to Birth on Lung, Heart, and Immune Outcomes in the C57BL/6 Mouse Model
This study aimed to characterize the long-term impact of mid-pregnancy inorganic arsenic exposure on the lung, heart, and immune system, including infectious disease response using the C57BL/6 mouse model. Mice were exposed from gestational day 9 till birth to either 0 or 1000µg/L sodium (meta)arsenite in drinking water. Male and female offspring assessed at adulthood (10-12 weeks of age) did not show significant effects on recovery outcomes after ischemia reperfusion injury but did exhibit increased airway hyperresponsiveness compared to controls. Flow cytometric analysis revealed significantly greater total numbers of c...
Source: Toxicology Letters - May 27, 2023 Category: Toxicology Authors: Kristal A Rychlik Emily J Illingworth Ian F Sanchez Sarah E Attreed Prithvi Sinha Kevin M Casin Nicole Taube Jeff Loube Rokeya Tasneen Raihan Kabir Eric Nuermberger Wayne Mitzner Mark J Kohr Fenna C M Sill é Source Type: research
Aryl hydrocarbon receptor is regulated via multiple mechanisms in human keratinocytes
Toxicol Lett. 2023 May 20:S0378-4274(23)00185-6. doi: 10.1016/j.toxlet.2023.05.007. Online ahead of print.ABSTRACTAryl hydrocarbon receptor (AhR) is a basic helix-loop-helix transcription factor activated by polycyclic aromatic hydrocarbons of synthetic and natural origin. While a number of novel AhR ligands have been recently identified, little is known about their possible influence on AhR levels and stability. We used western blot, qRT-PCR and immunocytochemistry to determine the effects of AhR ligands on AhR expression in N-TERT (N-TERT1) immortalized human keratinocytes, and immunohistochemistry to assess patterns of ...
Source: Toxicology Letters - May 22, 2023 Category: Toxicology Authors: S G Rudyak L A Usakin E A Tverye E D Robertson A A Panteleyev Source Type: research
