The role of non ‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)
Int J Oncol. 2021 Sep;59(3):69. doi: 10.3892/ijo.2021.5249. Epub 2021 Jul 23.ABSTRACTOsteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis and insensitivity to chemoradiotherapy. Non‑coding RNAs are transcripts that do not encode proteins. A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression. It has been confirmed that non‑coding RNAs exert their regulatory function...
Source: International Journal of Oncology - July 23, 2021 Category: Cancer & Oncology Authors: Gu Yang Yanjiao Wu Rongxue Wan Hongxun Sang Huan Liu Wenhua Huang Source Type: research

The role of non ‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)
Int J Oncol. 2021 Sep;59(3):69. doi: 10.3892/ijo.2021.5249. Epub 2021 Jul 23.ABSTRACTOsteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis and insensitivity to chemoradiotherapy. Non‑coding RNAs are transcripts that do not encode proteins. A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression. It has been confirmed that non‑coding RNAs exert their regulatory function...
Source: International Journal of Oncology - July 23, 2021 Category: Cancer & Oncology Authors: Gu Yang Yanjiao Wu Rongxue Wan Hongxun Sang Huan Liu Wenhua Huang Source Type: research

The role of non ‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)
Int J Oncol. 2021 Sep;59(3):69. doi: 10.3892/ijo.2021.5249. Epub 2021 Jul 23.ABSTRACTOsteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis and insensitivity to chemoradiotherapy. Non‑coding RNAs are transcripts that do not encode proteins. A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression. It has been confirmed that non‑coding RNAs exert their regulatory function...
Source: International Journal of Oncology - July 23, 2021 Category: Cancer & Oncology Authors: Gu Yang Yanjiao Wu Rongxue Wan Hongxun Sang Huan Liu Wenhua Huang Source Type: research

Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti ‑tubulin tetrahydrothieno[2,3‑c]pyridine derivative and a peptide nucleic acid targeting miR‑221‑3p
Int J Oncol. 2021 Aug;59(2):61. doi: 10.3892/ijo.2021.5241. Epub 2021 Jul 19.ABSTRACTIn the development of novel and more effective anticancer approaches, combined treatments appear to be of great interest, based on the possibility of obtaining relevant biological or therapeutic effects using lower concentrations of single drugs. Combination therapy may prove to be of utmost significance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer cases of the central nervous system, with a median survival rate of 15 months. As regards novel therapeutic approaches, the authors have recently ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Matteo Zurlo Romeo Romagnoli Paola Oliva Jessica Gasparello Alessia Finotti Roberto Gambari Source Type: research

Exosomal transfer of miR ‑25‑3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7
Int J Oncol. 2021 Aug;59(2):64. doi: 10.3892/ijo.2021.5244. Epub 2021 Jul 19.ABSTRACTIntrinsic or acquired resistance to temozolomide (TMZ) is a frequent occurrence in patients with glioblastoma (GBM). Accumulating evidence has indicated that the exosomal transfer of proteins and RNAs may confer TMZ resistance to recipient cells; however, the potential molecular mechanisms are not fully understood. Thus, the aim of the present study was to elucidate the possible role of exosomal microRNAs (miRNAs/miRs) in the acquired resistance to TMZ in GBM. A TMZ‑resistant GBM cell line (A172R) was used, and exosomes derived from A172...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jianxin Wang Tianxiao Li Bin Wang Source Type: research

Endoplasmic reticulum stress ‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)
Int J Oncol. 2021 Aug;59(2):60. doi: 10.3892/ijo.2021.5240. Epub 2021 Jul 19.ABSTRACTThe endoplasmic reticulum (ER) is an essential organelle for protein synthesis, folding and modification, lipid synthesis, and calcium storage. When endogenous or exogenous stimuli lead to ER‑synthesized protein folding dysfunction, numerous unfolded or misfolded proteins accumulate in the ER cavity and cause a series of subsequent responses, referred to as ER stress. If ER stress is continuous, the unfolded protein response (UPR) is not enough to remove the accumulated unfolded and misfolded proteins, and thus, UPR signaling pathways wi...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Pengfei Shi Zhuohang Zhang Jie Xu Li Zhang Hongjuan Cui Source Type: research

Macrophage migration inhibitory factor in the pathogenesis of leukemia (Review)
This article focuses on the functional role of MIF and its pathway in cancer, particularly in leukemia. MIF/CD74 interaction serves prominent roles in tumor cell survival, such as upregulating BCL‑2 and CD84 expression, and activating receptor‑type tyrosine phosphatase ζ. Furthermore, MIF upregulation forms a pro‑tumor microenvironment in response to hypoxia‑induced factors and promotes pro‑inflammatory cytokine production. Additionally, polymorphisms of the MIF promoter sequence are associated with leukemia development. MIF signal‑targeted early clinical trials show positive results. Overall, these effort...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Yaosheng Luo Xiao Wang Jie Shen Jie Yao Source Type: research

[Corrigendum] Emerging roles of non ‑coding RNAs in the response of rectal cancer to radiotherapy (Review)
Int J Oncol. 2021 Sep;59(3):67. doi: 10.3892/ijo.2021.5247. Epub 2021 Jul 19.ABSTRACTFollowing the publication of the above review article, the authors have realized that they overlooked including the funding information in the Declarations section. Therefore, the following text should also have been included with the review: Funding: The present review was supported by the National Research Foundation of Korea grant funded by the Korean government (grant no. 2020R1F1A1061122) and Gachon University Research fund of 2018 (GCU-2018-0670) to SH. The authors regret their oversight, apologize to the funding bodies concerned, an...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huyen Trang Ha Thi Hong-Quan Duong Suntaek Hong Source Type: research

[Retracted] MicroRNA ‑107 inhibits tumor growth and metastasis by targeting the BDNF‑mediated PI3K/AKT pathway in human non‑small lung cancer
Int J Oncol. 2021 Sep;59(3):66. doi: 10.3892/ijo.2021.5246. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data featured in Fig. 7, and the tumour images in Fig. 2, were strikingly similar to data appearing in different form in other articles by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere prior to its submission to International Journal of Oncology, the Edit...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huan Xia Yang Li Xiaohong Lv Source Type: research

NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells
Int J Oncol. 2021 Aug;59(2):63. doi: 10.3892/ijo.2021.5243. Epub 2021 Jul 19.ABSTRACTNADPH oxidases (NOXs) are a family of transmembrane proteins that generate reactive oxygen species. It was previously reported that patients with colon cancer who had high NOX5 expression had poor prognosis. However, no studies have investigated the cellular functions of NOX5 in colon cancer. The present study aimed to clarify the relationship between NOX5 and cancer development using an in vitro model. Reverse transcription‑quantitative PCR was performed to determine the NOX5 expression levels of colon cancer cell lines. NOX5‑knockdow...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Naoki Ashizawa Hiroki Shimizu Katsutoshi Shoda Shinji Furuya Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Keita Katsurahara Atsushi Shiozaki Daisuke Ichikawa Source Type: research

[Retracted] MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2
Int J Oncol. 2021 Sep;59(3):65. doi: 10.3892/ijo.2021.5245. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the scratch-wound assay data shown in Fig. 3A and Transwell cell migration data shown in Figs. 3B and 6B were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to International Journal of Oncology, the ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jian Li Jian Yuan Xianrui Yuan Jie Zhao Zhiping Zhang Ling Weng Jingping Liu Source Type: research

MUC1 is an oncoprotein with a significant role in apoptosis (Review)
Int J Oncol. 2021 Sep;59(3):68. doi: 10.3892/ijo.2021.5248. Epub 2021 Jul 19.ABSTRACTMucin 1 (MUC1) is a membrane‑bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation. Overexpression of MUC1 together with loss of polarization and hypoglycosylation are associated with resistance to apoptosis, which is the process that results in efficient removal of damaged cells. Inhibition of the apoptotic process is responsible for tumor development, tumor progression and drug resistance. MUC1 is considered as an oncogenic molecule that is involved in various signaling pathways responsible ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Katarzyna Supruniuk Iwona Radziejewska Source Type: research

Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti ‑tubulin tetrahydrothieno[2,3‑c]pyridine derivative and a peptide nucleic acid targeting miR‑221‑3p
Int J Oncol. 2021 Aug;59(2):61. doi: 10.3892/ijo.2021.5241. Epub 2021 Jul 19.ABSTRACTIn the development of novel and more effective anticancer approaches, combined treatments appear to be of great interest, based on the possibility of obtaining relevant biological or therapeutic effects using lower concentrations of single drugs. Combination therapy may prove to be of utmost significance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer cases of the central nervous system, with a median survival rate of 15 months. As regards novel therapeutic approaches, the authors have recently ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Matteo Zurlo Romeo Romagnoli Paola Oliva Jessica Gasparello Alessia Finotti Roberto Gambari Source Type: research

Exosomal transfer of miR ‑25‑3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7
Int J Oncol. 2021 Aug;59(2):64. doi: 10.3892/ijo.2021.5244. Epub 2021 Jul 19.ABSTRACTIntrinsic or acquired resistance to temozolomide (TMZ) is a frequent occurrence in patients with glioblastoma (GBM). Accumulating evidence has indicated that the exosomal transfer of proteins and RNAs may confer TMZ resistance to recipient cells; however, the potential molecular mechanisms are not fully understood. Thus, the aim of the present study was to elucidate the possible role of exosomal microRNAs (miRNAs/miRs) in the acquired resistance to TMZ in GBM. A TMZ‑resistant GBM cell line (A172R) was used, and exosomes derived from A172...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jianxin Wang Tianxiao Li Bin Wang Source Type: research

Endoplasmic reticulum stress ‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)
Int J Oncol. 2021 Aug;59(2):60. doi: 10.3892/ijo.2021.5240. Epub 2021 Jul 19.ABSTRACTThe endoplasmic reticulum (ER) is an essential organelle for protein synthesis, folding and modification, lipid synthesis, and calcium storage. When endogenous or exogenous stimuli lead to ER‑synthesized protein folding dysfunction, numerous unfolded or misfolded proteins accumulate in the ER cavity and cause a series of subsequent responses, referred to as ER stress. If ER stress is continuous, the unfolded protein response (UPR) is not enough to remove the accumulated unfolded and misfolded proteins, and thus, UPR signaling pathways wi...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Pengfei Shi Zhuohang Zhang Jie Xu Li Zhang Hongjuan Cui Source Type: research

Macrophage migration inhibitory factor in the pathogenesis of leukemia (Review)
This article focuses on the functional role of MIF and its pathway in cancer, particularly in leukemia. MIF/CD74 interaction serves prominent roles in tumor cell survival, such as upregulating BCL‑2 and CD84 expression, and activating receptor‑type tyrosine phosphatase ζ. Furthermore, MIF upregulation forms a pro‑tumor microenvironment in response to hypoxia‑induced factors and promotes pro‑inflammatory cytokine production. Additionally, polymorphisms of the MIF promoter sequence are associated with leukemia development. MIF signal‑targeted early clinical trials show positive results. Overall, these effort...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Yaosheng Luo Xiao Wang Jie Shen Jie Yao Source Type: research

[Corrigendum] Emerging roles of non ‑coding RNAs in the response of rectal cancer to radiotherapy (Review)
Int J Oncol. 2021 Sep;59(3):67. doi: 10.3892/ijo.2021.5247. Epub 2021 Jul 19.ABSTRACTFollowing the publication of the above review article, the authors have realized that they overlooked including the funding information in the Declarations section. Therefore, the following text should also have been included with the review: Funding: The present review was supported by the National Research Foundation of Korea grant funded by the Korean government (grant no. 2020R1F1A1061122) and Gachon University Research fund of 2018 (GCU-2018-0670) to SH. The authors regret their oversight, apologize to the funding bodies concerned, an...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huyen Trang Ha Thi Hong-Quan Duong Suntaek Hong Source Type: research

[Retracted] MicroRNA ‑107 inhibits tumor growth and metastasis by targeting the BDNF‑mediated PI3K/AKT pathway in human non‑small lung cancer
Int J Oncol. 2021 Sep;59(3):66. doi: 10.3892/ijo.2021.5246. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data featured in Fig. 7, and the tumour images in Fig. 2, were strikingly similar to data appearing in different form in other articles by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere prior to its submission to International Journal of Oncology, the Edit...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huan Xia Yang Li Xiaohong Lv Source Type: research

NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells
Int J Oncol. 2021 Aug;59(2):63. doi: 10.3892/ijo.2021.5243. Epub 2021 Jul 19.ABSTRACTNADPH oxidases (NOXs) are a family of transmembrane proteins that generate reactive oxygen species. It was previously reported that patients with colon cancer who had high NOX5 expression had poor prognosis. However, no studies have investigated the cellular functions of NOX5 in colon cancer. The present study aimed to clarify the relationship between NOX5 and cancer development using an in vitro model. Reverse transcription‑quantitative PCR was performed to determine the NOX5 expression levels of colon cancer cell lines. NOX5‑knockdow...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Naoki Ashizawa Hiroki Shimizu Katsutoshi Shoda Shinji Furuya Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Keita Katsurahara Atsushi Shiozaki Daisuke Ichikawa Source Type: research

[Retracted] MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2
Int J Oncol. 2021 Sep;59(3):65. doi: 10.3892/ijo.2021.5245. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the scratch-wound assay data shown in Fig. 3A and Transwell cell migration data shown in Figs. 3B and 6B were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to International Journal of Oncology, the ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jian Li Jian Yuan Xianrui Yuan Jie Zhao Zhiping Zhang Ling Weng Jingping Liu Source Type: research

MUC1 is an oncoprotein with a significant role in apoptosis (Review)
Int J Oncol. 2021 Sep;59(3):68. doi: 10.3892/ijo.2021.5248. Epub 2021 Jul 19.ABSTRACTMucin 1 (MUC1) is a membrane‑bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation. Overexpression of MUC1 together with loss of polarization and hypoglycosylation are associated with resistance to apoptosis, which is the process that results in efficient removal of damaged cells. Inhibition of the apoptotic process is responsible for tumor development, tumor progression and drug resistance. MUC1 is considered as an oncogenic molecule that is involved in various signaling pathways responsible ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Katarzyna Supruniuk Iwona Radziejewska Source Type: research

Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti ‑tubulin tetrahydrothieno[2,3‑c]pyridine derivative and a peptide nucleic acid targeting miR‑221‑3p
Int J Oncol. 2021 Aug;59(2):61. doi: 10.3892/ijo.2021.5241. Epub 2021 Jul 19.ABSTRACTIn the development of novel and more effective anticancer approaches, combined treatments appear to be of great interest, based on the possibility of obtaining relevant biological or therapeutic effects using lower concentrations of single drugs. Combination therapy may prove to be of utmost significance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer cases of the central nervous system, with a median survival rate of 15 months. As regards novel therapeutic approaches, the authors have recently ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Matteo Zurlo Romeo Romagnoli Paola Oliva Jessica Gasparello Alessia Finotti Roberto Gambari Source Type: research

Exosomal transfer of miR ‑25‑3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7
Int J Oncol. 2021 Aug;59(2):64. doi: 10.3892/ijo.2021.5244. Epub 2021 Jul 19.ABSTRACTIntrinsic or acquired resistance to temozolomide (TMZ) is a frequent occurrence in patients with glioblastoma (GBM). Accumulating evidence has indicated that the exosomal transfer of proteins and RNAs may confer TMZ resistance to recipient cells; however, the potential molecular mechanisms are not fully understood. Thus, the aim of the present study was to elucidate the possible role of exosomal microRNAs (miRNAs/miRs) in the acquired resistance to TMZ in GBM. A TMZ‑resistant GBM cell line (A172R) was used, and exosomes derived from A172...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jianxin Wang Tianxiao Li Bin Wang Source Type: research

Endoplasmic reticulum stress ‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)
Int J Oncol. 2021 Aug;59(2):60. doi: 10.3892/ijo.2021.5240. Epub 2021 Jul 19.ABSTRACTThe endoplasmic reticulum (ER) is an essential organelle for protein synthesis, folding and modification, lipid synthesis, and calcium storage. When endogenous or exogenous stimuli lead to ER‑synthesized protein folding dysfunction, numerous unfolded or misfolded proteins accumulate in the ER cavity and cause a series of subsequent responses, referred to as ER stress. If ER stress is continuous, the unfolded protein response (UPR) is not enough to remove the accumulated unfolded and misfolded proteins, and thus, UPR signaling pathways wi...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Pengfei Shi Zhuohang Zhang Jie Xu Li Zhang Hongjuan Cui Source Type: research

Macrophage migration inhibitory factor in the pathogenesis of leukemia (Review)
This article focuses on the functional role of MIF and its pathway in cancer, particularly in leukemia. MIF/CD74 interaction serves prominent roles in tumor cell survival, such as upregulating BCL‑2 and CD84 expression, and activating receptor‑type tyrosine phosphatase ζ. Furthermore, MIF upregulation forms a pro‑tumor microenvironment in response to hypoxia‑induced factors and promotes pro‑inflammatory cytokine production. Additionally, polymorphisms of the MIF promoter sequence are associated with leukemia development. MIF signal‑targeted early clinical trials show positive results. Overall, these effort...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Yaosheng Luo Xiao Wang Jie Shen Jie Yao Source Type: research

[Corrigendum] Emerging roles of non ‑coding RNAs in the response of rectal cancer to radiotherapy (Review)
Int J Oncol. 2021 Sep;59(3):67. doi: 10.3892/ijo.2021.5247. Epub 2021 Jul 19.ABSTRACTFollowing the publication of the above review article, the authors have realized that they overlooked including the funding information in the Declarations section. Therefore, the following text should also have been included with the review: Funding: The present review was supported by the National Research Foundation of Korea grant funded by the Korean government (grant no. 2020R1F1A1061122) and Gachon University Research fund of 2018 (GCU-2018-0670) to SH. The authors regret their oversight, apologize to the funding bodies concerned, an...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huyen Trang Ha Thi Hong-Quan Duong Suntaek Hong Source Type: research

[Retracted] MicroRNA ‑107 inhibits tumor growth and metastasis by targeting the BDNF‑mediated PI3K/AKT pathway in human non‑small lung cancer
Int J Oncol. 2021 Sep;59(3):66. doi: 10.3892/ijo.2021.5246. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data featured in Fig. 7, and the tumour images in Fig. 2, were strikingly similar to data appearing in different form in other articles by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere prior to its submission to International Journal of Oncology, the Edit...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Huan Xia Yang Li Xiaohong Lv Source Type: research

NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells
Int J Oncol. 2021 Aug;59(2):63. doi: 10.3892/ijo.2021.5243. Epub 2021 Jul 19.ABSTRACTNADPH oxidases (NOXs) are a family of transmembrane proteins that generate reactive oxygen species. It was previously reported that patients with colon cancer who had high NOX5 expression had poor prognosis. However, no studies have investigated the cellular functions of NOX5 in colon cancer. The present study aimed to clarify the relationship between NOX5 and cancer development using an in vitro model. Reverse transcription‑quantitative PCR was performed to determine the NOX5 expression levels of colon cancer cell lines. NOX5‑knockdow...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Naoki Ashizawa Hiroki Shimizu Katsutoshi Shoda Shinji Furuya Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Keita Katsurahara Atsushi Shiozaki Daisuke Ichikawa Source Type: research

[Retracted] MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2
Int J Oncol. 2021 Sep;59(3):65. doi: 10.3892/ijo.2021.5245. Epub 2021 Jul 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the scratch-wound assay data shown in Fig. 3A and Transwell cell migration data shown in Figs. 3B and 6B were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to International Journal of Oncology, the ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Jian Li Jian Yuan Xianrui Yuan Jie Zhao Zhiping Zhang Ling Weng Jingping Liu Source Type: research

MUC1 is an oncoprotein with a significant role in apoptosis (Review)
Int J Oncol. 2021 Sep;59(3):68. doi: 10.3892/ijo.2021.5248. Epub 2021 Jul 19.ABSTRACTMucin 1 (MUC1) is a membrane‑bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation. Overexpression of MUC1 together with loss of polarization and hypoglycosylation are associated with resistance to apoptosis, which is the process that results in efficient removal of damaged cells. Inhibition of the apoptotic process is responsible for tumor development, tumor progression and drug resistance. MUC1 is considered as an oncogenic molecule that is involved in various signaling pathways responsible ...
Source: International Journal of Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Katarzyna Supruniuk Iwona Radziejewska Source Type: research

[Retracted] MiR ‑132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3
Int J Oncol. 2021 Aug;59(2):58. doi: 10.3892/ijo.2021.5238. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the data shown in Figs. 2C and 3A bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatinal Journal of Oncology, the Editor has decided that this paper should be retracted from the Journal...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Kai Liu Xingliang Li Yuchen Cao Yuanyuan Ge Jianmeng Wang Bo Shi Source Type: research

[Retracted] miR ‑338‑3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2
Int J Oncol. 2021 Aug;59(2):57. doi: 10.3892/ijo.2021.5237. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 5C and D bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatiοnal Journal of Oncology, the Editor has decided that this paper should be re...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Chunyan Wen Xiaojun Liu Hongxi Ma Wenjie Zhang Haifeng Li Source Type: research

Cancer ‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway
In conclusion, the results of the present study suggested that CAFs promoted the M2 polarization of macrophages and induced PAI‑1 secretion via CXCL12. Furthermore, it was found that PAI‑1 produced by the TAMs enhanced the malignant behavior of the HCC cells. Therefore, these factors may be targets for inhibiting the crosstalk between tumor cells, CAFs and TAMs.PMID:34195849 | PMC:PMC8253588 | DOI:10.3892/ijo.2021.5239 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shuhai Chen Yuji Morine Kazunori Tokuda Shinichiro Yamada Yu Saito Masaaki Nishi Tetsuya Ikemoto Mitsuo Shimada Source Type: research

Downregulated expression of IL ‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma
In conclusion, lower IL‑28RA expression may contribute to the pathogenesis of PDAC, where results from the present may provide further insights into the progression of PDAC, in addition to highlighting potentially novel therapeutic targets for this disease.PMID:34195850 | DOI:10.3892/ijo.2021.5235 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Li Liu Yinliang Qi Dake Huang Yechuan Xu Mingcong Li Zhou Hong Yanan Gu Bo Jia Xin Luo Sumei Zhang Shengquan Zhang Source Type: research

lncRNA HCP5 acts as a ceRNA to regulate EZH2 by sponging miR ‑138‑5p in cutaneous squamous cell carcinoma
In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. This study may provide a new perspective for understanding the molecular mechanism and treatment of CSCC.PMID:34195851 | PMC:PMC8253586 | DOI:10.3892/ijo.2021.5236 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shibo Zou Ya Gao Shutang Zhang Source Type: research

[Retracted] MiR ‑132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3
Int J Oncol. 2021 Aug;59(2):58. doi: 10.3892/ijo.2021.5238. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the data shown in Figs. 2C and 3A bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatinal Journal of Oncology, the Editor has decided that this paper should be retracted from the Journal...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Kai Liu Xingliang Li Yuchen Cao Yuanyuan Ge Jianmeng Wang Bo Shi Source Type: research

[Retracted] miR ‑338‑3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2
Int J Oncol. 2021 Aug;59(2):57. doi: 10.3892/ijo.2021.5237. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 5C and D bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatiοnal Journal of Oncology, the Editor has decided that this paper should be re...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Chunyan Wen Xiaojun Liu Hongxi Ma Wenjie Zhang Haifeng Li Source Type: research

Cancer ‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway
In conclusion, the results of the present study suggested that CAFs promoted the M2 polarization of macrophages and induced PAI‑1 secretion via CXCL12. Furthermore, it was found that PAI‑1 produced by the TAMs enhanced the malignant behavior of the HCC cells. Therefore, these factors may be targets for inhibiting the crosstalk between tumor cells, CAFs and TAMs.PMID:34195849 | PMC:PMC8253588 | DOI:10.3892/ijo.2021.5239 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shuhai Chen Yuji Morine Kazunori Tokuda Shinichiro Yamada Yu Saito Masaaki Nishi Tetsuya Ikemoto Mitsuo Shimada Source Type: research

Downregulated expression of IL ‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma
In conclusion, lower IL‑28RA expression may contribute to the pathogenesis of PDAC, where results from the present may provide further insights into the progression of PDAC, in addition to highlighting potentially novel therapeutic targets for this disease.PMID:34195850 | DOI:10.3892/ijo.2021.5235 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Li Liu Yinliang Qi Dake Huang Yechuan Xu Mingcong Li Zhou Hong Yanan Gu Bo Jia Xin Luo Sumei Zhang Shengquan Zhang Source Type: research

lncRNA HCP5 acts as a ceRNA to regulate EZH2 by sponging miR ‑138‑5p in cutaneous squamous cell carcinoma
In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. This study may provide a new perspective for understanding the molecular mechanism and treatment of CSCC.PMID:34195851 | PMC:PMC8253586 | DOI:10.3892/ijo.2021.5236 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shibo Zou Ya Gao Shutang Zhang Source Type: research

[Retracted] MiR ‑132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3
Int J Oncol. 2021 Aug;59(2):58. doi: 10.3892/ijo.2021.5238. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the data shown in Figs. 2C and 3A bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatinal Journal of Oncology, the Editor has decided that this paper should be retracted from the Journal...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Kai Liu Xingliang Li Yuchen Cao Yuanyuan Ge Jianmeng Wang Bo Shi Source Type: research

[Retracted] miR ‑338‑3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2
Int J Oncol. 2021 Aug;59(2):57. doi: 10.3892/ijo.2021.5237. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 5C and D bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatiοnal Journal of Oncology, the Editor has decided that this paper should be re...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Chunyan Wen Xiaojun Liu Hongxi Ma Wenjie Zhang Haifeng Li Source Type: research

Cancer ‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway
In conclusion, the results of the present study suggested that CAFs promoted the M2 polarization of macrophages and induced PAI‑1 secretion via CXCL12. Furthermore, it was found that PAI‑1 produced by the TAMs enhanced the malignant behavior of the HCC cells. Therefore, these factors may be targets for inhibiting the crosstalk between tumor cells, CAFs and TAMs.PMID:34195849 | PMC:PMC8253588 | DOI:10.3892/ijo.2021.5239 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shuhai Chen Yuji Morine Kazunori Tokuda Shinichiro Yamada Yu Saito Masaaki Nishi Tetsuya Ikemoto Mitsuo Shimada Source Type: research

Downregulated expression of IL ‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma
In conclusion, lower IL‑28RA expression may contribute to the pathogenesis of PDAC, where results from the present may provide further insights into the progression of PDAC, in addition to highlighting potentially novel therapeutic targets for this disease.PMID:34195850 | DOI:10.3892/ijo.2021.5235 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Li Liu Yinliang Qi Dake Huang Yechuan Xu Mingcong Li Zhou Hong Yanan Gu Bo Jia Xin Luo Sumei Zhang Shengquan Zhang Source Type: research

lncRNA HCP5 acts as a ceRNA to regulate EZH2 by sponging miR ‑138‑5p in cutaneous squamous cell carcinoma
In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. This study may provide a new perspective for understanding the molecular mechanism and treatment of CSCC.PMID:34195851 | PMC:PMC8253586 | DOI:10.3892/ijo.2021.5236 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shibo Zou Ya Gao Shutang Zhang Source Type: research

[Retracted] MiR ‑132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3
Int J Oncol. 2021 Aug;59(2):58. doi: 10.3892/ijo.2021.5238. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the data shown in Figs. 2C and 3A bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatinal Journal of Oncology, the Editor has decided that this paper should be retracted from the Journal...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Kai Liu Xingliang Li Yuchen Cao Yuanyuan Ge Jianmeng Wang Bo Shi Source Type: research

[Retracted] miR ‑338‑3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2
Int J Oncol. 2021 Aug;59(2):57. doi: 10.3892/ijo.2021.5237. Epub 2021 Jul 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 5C and D bore unexpected similarities to data appearing in different form in other articles by different authors. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Internatiοnal Journal of Oncology, the Editor has decided that this paper should be re...
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Chunyan Wen Xiaojun Liu Hongxi Ma Wenjie Zhang Haifeng Li Source Type: research

Cancer ‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway
In conclusion, the results of the present study suggested that CAFs promoted the M2 polarization of macrophages and induced PAI‑1 secretion via CXCL12. Furthermore, it was found that PAI‑1 produced by the TAMs enhanced the malignant behavior of the HCC cells. Therefore, these factors may be targets for inhibiting the crosstalk between tumor cells, CAFs and TAMs.PMID:34195849 | PMC:PMC8253588 | DOI:10.3892/ijo.2021.5239 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shuhai Chen Yuji Morine Kazunori Tokuda Shinichiro Yamada Yu Saito Masaaki Nishi Tetsuya Ikemoto Mitsuo Shimada Source Type: research

Downregulated expression of IL ‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma
In conclusion, lower IL‑28RA expression may contribute to the pathogenesis of PDAC, where results from the present may provide further insights into the progression of PDAC, in addition to highlighting potentially novel therapeutic targets for this disease.PMID:34195850 | DOI:10.3892/ijo.2021.5235 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Li Liu Yinliang Qi Dake Huang Yechuan Xu Mingcong Li Zhou Hong Yanan Gu Bo Jia Xin Luo Sumei Zhang Shengquan Zhang Source Type: research

lncRNA HCP5 acts as a ceRNA to regulate EZH2 by sponging miR ‑138‑5p in cutaneous squamous cell carcinoma
In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. This study may provide a new perspective for understanding the molecular mechanism and treatment of CSCC.PMID:34195851 | PMC:PMC8253586 | DOI:10.3892/ijo.2021.5236 (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 1, 2021 Category: Cancer & Oncology Authors: Shibo Zou Ya Gao Shutang Zhang Source Type: research