MDIG, a 2 ‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer
Int J Oncol. 2022 Jul;61(1):82. doi: 10.3892/ijo.2022.5372. Epub 2022 May 18.ABSTRACTRecent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell l...
Source: International Journal of Oncology - May 18, 2022 Category: Cancer & Oncology Authors: Feng Geng Wei Yang Dandan Song Haijia Hou Bing Han Yecheng Chen Hongwen Zhao Source Type: research

MDIG, a 2 ‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer
Int J Oncol. 2022 Jul;61(1):82. doi: 10.3892/ijo.2022.5372. Epub 2022 May 18.ABSTRACTRecent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell l...
Source: International Journal of Oncology - May 18, 2022 Category: Cancer & Oncology Authors: Feng Geng Wei Yang Dandan Song Haijia Hou Bing Han Yecheng Chen Hongwen Zhao Source Type: research

MDIG, a 2 ‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer
Int J Oncol. 2022 Jul;61(1):82. doi: 10.3892/ijo.2022.5372. Epub 2022 May 18.ABSTRACTRecent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell l...
Source: International Journal of Oncology - May 18, 2022 Category: Cancer & Oncology Authors: Feng Geng Wei Yang Dandan Song Haijia Hou Bing Han Yecheng Chen Hongwen Zhao Source Type: research

MDIG, a 2 ‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer
Int J Oncol. 2022 Jul;61(1):82. doi: 10.3892/ijo.2022.5372. Epub 2022 May 18.ABSTRACTRecent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell l...
Source: International Journal of Oncology - May 18, 2022 Category: Cancer & Oncology Authors: Feng Geng Wei Yang Dandan Song Haijia Hou Bing Han Yecheng Chen Hongwen Zhao Source Type: research

The TLR7/8 agonist R848 optimizes host and tumor immunity to improve therapeutic efficacy in murine lung cancer
Int J Oncol. 2022 Jul;61(1):81. doi: 10.3892/ijo.2022.5371. Epub 2022 May 13.ABSTRACTTreatment with the Toll‑like receptor 7 (TLR7) agonist, resiquimod (R848), is effective in various types of cancer, such as breast, pancreatic and colorectal cancer. The reported antitumor effect of R848 in lung cancer is considered to be achieved by targeting macrophages. In the present study, it was demonstrated that TLR7 expression on various immune cell types initially rises, then declines in the late stage of lung cancer. Intraperitoneal injection of R848 resulted in a reduction in tumor burden and prolonged survival in both subcuta...
Source: International Journal of Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Jianchun Zhou Yu Xu Guansong Wang Tonghua Mei Hao Yang Yuliang Liu Source Type: research

The TLR7/8 agonist R848 optimizes host and tumor immunity to improve therapeutic efficacy in murine lung cancer
Int J Oncol. 2022 Jul;61(1):81. doi: 10.3892/ijo.2022.5371. Epub 2022 May 13.ABSTRACTTreatment with the Toll‑like receptor 7 (TLR7) agonist, resiquimod (R848), is effective in various types of cancer, such as breast, pancreatic and colorectal cancer. The reported antitumor effect of R848 in lung cancer is considered to be achieved by targeting macrophages. In the present study, it was demonstrated that TLR7 expression on various immune cell types initially rises, then declines in the late stage of lung cancer. Intraperitoneal injection of R848 resulted in a reduction in tumor burden and prolonged survival in both subcuta...
Source: International Journal of Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Jianchun Zhou Yu Xu Guansong Wang Tonghua Mei Hao Yang Yuliang Liu Source Type: research

The TLR7/8 agonist R848 optimizes host and tumor immunity to improve therapeutic efficacy in murine lung cancer
Int J Oncol. 2022 Jul;61(1):81. doi: 10.3892/ijo.2022.5371. Epub 2022 May 13.ABSTRACTTreatment with the Toll‑like receptor 7 (TLR7) agonist, resiquimod (R848), is effective in various types of cancer, such as breast, pancreatic and colorectal cancer. The reported antitumor effect of R848 in lung cancer is considered to be achieved by targeting macrophages. In the present study, it was demonstrated that TLR7 expression on various immune cell types initially rises, then declines in the late stage of lung cancer. Intraperitoneal injection of R848 resulted in a reduction in tumor burden and prolonged survival in both subcuta...
Source: International Journal of Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Jianchun Zhou Yu Xu Guansong Wang Tonghua Mei Hao Yang Yuliang Liu Source Type: research

The TLR7/8 agonist R848 optimizes host and tumor immunity to improve therapeutic efficacy in murine lung cancer
Int J Oncol. 2022 Jul;61(1):81. doi: 10.3892/ijo.2022.5371. Epub 2022 May 13.ABSTRACTTreatment with the Toll‑like receptor 7 (TLR7) agonist, resiquimod (R848), is effective in various types of cancer, such as breast, pancreatic and colorectal cancer. The reported antitumor effect of R848 in lung cancer is considered to be achieved by targeting macrophages. In the present study, it was demonstrated that TLR7 expression on various immune cell types initially rises, then declines in the late stage of lung cancer. Intraperitoneal injection of R848 resulted in a reduction in tumor burden and prolonged survival in both subcuta...
Source: International Journal of Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Jianchun Zhou Yu Xu Guansong Wang Tonghua Mei Hao Yang Yuliang Liu Source Type: research

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation
Int J Oncol. 2022 Jun;60(6):79. doi: 10.3892/ijo.2022.5369. Epub 2022 May 11.ABSTRACTMetabolic rewiring fuels rapid cancer cell proliferation by promoting adjustments in energetic resources, and increasing glucose uptake and its conversion into lactate, even in the presence of oxygen. Furthermore, solid tumors often contain hypoxic areas and can rapidly adapt to low oxygen conditions by activating hypoxia inducible factor (HIF)‑1α and several downstream pathways, thus sustaining cell survival and metabolic reprogramming. Since TNF receptor‑associated protein 1 (TRAP1) is a HSP90 molecular chaperone upregulated in seve...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Giuseppina Bruno Valeria Li Bergolis Annamaria Piscazzi Fabiana Crispo Valentina Condelli Pietro Zoppoli Francesca Maddalena Michele Pietrafesa Guido Giordano Danilo Swann Matassa Franca Esposito Matteo Landriscina Source Type: research

Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF ‑binding protein
Int J Oncol. 2022 Jul;61(1):80. doi: 10.3892/ijo.2022.5370. Epub 2022 May 11.ABSTRACTDrug repositioning is a strategy for repurposing the approved or investigational drugs that are outside the scope of the original medical indication. Memantine is used as a non‑competitive N‑methyl‑D‑aspartate receptor antagonist to prevent glutamate‑mediated excitotoxicity in Alzheimer's disease, and is one of the promising agents which is utilized for the purpose of cancer therapy. However, the association between memantine and Golgi glycoprotein 1 (GLG1), an intracellular fibroblast growth factor receptor, in cancers has not y...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Fumio Yamaguchi Sumio Hayakawa Shota Kawashima Takayuki Asakura Yumiko Oishi Source Type: research

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation
Int J Oncol. 2022 Jun;60(6):79. doi: 10.3892/ijo.2022.5369. Epub 2022 May 11.ABSTRACTMetabolic rewiring fuels rapid cancer cell proliferation by promoting adjustments in energetic resources, and increasing glucose uptake and its conversion into lactate, even in the presence of oxygen. Furthermore, solid tumors often contain hypoxic areas and can rapidly adapt to low oxygen conditions by activating hypoxia inducible factor (HIF)‑1α and several downstream pathways, thus sustaining cell survival and metabolic reprogramming. Since TNF receptor‑associated protein 1 (TRAP1) is a HSP90 molecular chaperone upregulated in seve...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Giuseppina Bruno Valeria Li Bergolis Annamaria Piscazzi Fabiana Crispo Valentina Condelli Pietro Zoppoli Francesca Maddalena Michele Pietrafesa Guido Giordano Danilo Swann Matassa Franca Esposito Matteo Landriscina Source Type: research

Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF ‑binding protein
Int J Oncol. 2022 Jul;61(1):80. doi: 10.3892/ijo.2022.5370. Epub 2022 May 11.ABSTRACTDrug repositioning is a strategy for repurposing the approved or investigational drugs that are outside the scope of the original medical indication. Memantine is used as a non‑competitive N‑methyl‑D‑aspartate receptor antagonist to prevent glutamate‑mediated excitotoxicity in Alzheimer's disease, and is one of the promising agents which is utilized for the purpose of cancer therapy. However, the association between memantine and Golgi glycoprotein 1 (GLG1), an intracellular fibroblast growth factor receptor, in cancers has not y...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Fumio Yamaguchi Sumio Hayakawa Shota Kawashima Takayuki Asakura Yumiko Oishi Source Type: research

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation
Int J Oncol. 2022 Jun;60(6):79. doi: 10.3892/ijo.2022.5369. Epub 2022 May 11.ABSTRACTMetabolic rewiring fuels rapid cancer cell proliferation by promoting adjustments in energetic resources, and increasing glucose uptake and its conversion into lactate, even in the presence of oxygen. Furthermore, solid tumors often contain hypoxic areas and can rapidly adapt to low oxygen conditions by activating hypoxia inducible factor (HIF)‑1α and several downstream pathways, thus sustaining cell survival and metabolic reprogramming. Since TNF receptor‑associated protein 1 (TRAP1) is a HSP90 molecular chaperone upregulated in seve...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Giuseppina Bruno Valeria Li Bergolis Annamaria Piscazzi Fabiana Crispo Valentina Condelli Pietro Zoppoli Francesca Maddalena Michele Pietrafesa Guido Giordano Danilo Swann Matassa Franca Esposito Matteo Landriscina Source Type: research

Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF ‑binding protein
Int J Oncol. 2022 Jul;61(1):80. doi: 10.3892/ijo.2022.5370. Epub 2022 May 11.ABSTRACTDrug repositioning is a strategy for repurposing the approved or investigational drugs that are outside the scope of the original medical indication. Memantine is used as a non‑competitive N‑methyl‑D‑aspartate receptor antagonist to prevent glutamate‑mediated excitotoxicity in Alzheimer's disease, and is one of the promising agents which is utilized for the purpose of cancer therapy. However, the association between memantine and Golgi glycoprotein 1 (GLG1), an intracellular fibroblast growth factor receptor, in cancers has not y...
Source: International Journal of Oncology - May 11, 2022 Category: Cancer & Oncology Authors: Fumio Yamaguchi Sumio Hayakawa Shota Kawashima Takayuki Asakura Yumiko Oishi Source Type: research

Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor ‑associated macrophages into the tumor microenvironment of oral squamous cell carcinoma
Int J Oncol. 2022 Jun;60(6):78. doi: 10.3892/ijo.2022.5368. Epub 2022 May 6.ABSTRACTTumor‑associated macrophages (TAMs) are linked to the progression of numerous types of cancer. However, the effects of the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC), particularly the cancer stroma on TAMs, remains to be elucidated. In the present study, the effects of verrucous SCC‑associated stromal cells (VSCC‑SCs), SCC‑associated stromal cells (SCC‑SCs) and human dermal fibroblasts (HDFs) on the differentiation, proliferation and migration of macrophages in vitro was assayed using Giemsa staining, and ...
Source: International Journal of Oncology - May 6, 2022 Category: Cancer & Oncology Authors: Qiusheng Shan Kiyofumi Takabatake Hotaka Kawai May Wathone Oo Shintaro Sukegawa Masae Fujii Keisuke Nakano Hitoshi Nagatsuka Source Type: research