Targeting cancer stem cells in cholangiocarcinoma (Review).
Abstract The incidence of cholangiocarcinoma has been increasing steadily over the past 50 years, but the survival rates remained low due to the disease being highly resistant to non‑surgical treatment interventions. Cancer stem cell markers are expressed in cholangiocarcinoma, suggesting that they serve a significant role in the physiology of the disease. Cancer stem cells are frequently implicated in tumor relapse and acquired resistance to a number of therapeutic strategies, including chemotherapy, radiation and immune checkpoint inhibitors. Novel targeted therapies to eradicate cancer stem cells may assist i...
Source: International Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Authors: Mcgrath NA, Fu J, Gu SZ, Xie C Tags: Int J Oncol Source Type: research

Biomarkers of tumor invasiveness in proteomics (Review).
Abstract Over the past two decades, quantitative proteomics has emerged as an important tool for deciphering the complex molecular events involved in cancers. The number of references involving studies on the cancer metastatic process has doubled since 2010, while the last 5 years have seen the development of novel technologies combining deep proteome coverage capabilities with quantitative consistency and accuracy. To highlight key findings within this huge amount of information, the present review identified a list of tumor invasive biomarkers based on both the literature and data collected on a b...
Source: International Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Authors: Pouliquen DL, Boissard A, Coqueret O, Guette C Tags: Int J Oncol Source Type: research

Upregulation of miRNA ‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling.
Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling. Int J Oncol. 2020 May 26;: Authors: Xu X, Xia Y, Ma J, Li W, Niu N, Li X, Tao H, Xu J, He X Abstract MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate miRNA‑301a‑3p expres...
Source: International Journal of Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Xu X, Xia Y, Ma J, Li W, Niu N, Li X, Tao H, Xu J, He X Tags: Int J Oncol Source Type: research

Silencing IDO2 in dendritic cells: A novel strategy to strengthen cancer immunotherapy in a murine lung cancer model.
Abstract While dendritic cell (DC)‑based immunotherapy has achieved satisfactory results in animal models, its effects were not satisfactory as initially expected in clinical applications, despite the safety and varying degrees of effectiveness in various types of cancer. Improving the efficacy of the DC‑based vaccine is essential for cancer immunotherapy. The present study aimed to investigate methods with which to amplify and enhance the antitumor immune response of a DC‑based tumor vaccine by silencing the expression of indoleamine 2,3‑dioxygenase 2 (IDO2), a tryptophan rate‑limiting metabolic enzyme ...
Source: International Journal of Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Liu Y, Xu P, Liu H, Fang C, Guo H, Chen X, Tan M, Zhang Y, Min W Tags: Int J Oncol Source Type: research

Pan ‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. Int J Oncol. 2020 May 26;: Authors: Katopodis P, Anikin V, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E Abstract Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV2) is the cause of a new disease (COVID‑19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID‑19. SARS‑CoV‑2 infection of ...
Source: International Journal of Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Katopodis P, Anikin V, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E Tags: Int J Oncol Source Type: research

MicroRNA ‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma.
MicroRNA‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma. Int J Oncol. 2020 May 25;: Authors: Fu M, Chen CW, Yang LQ, Yang WW, Du ZH, Li YR, Li SL, Ge XY Abstract Salivary adenoid cystic carcinoma (SACC) exhibits slow continuous growth, frequent local recurrences and a high incidence of blood metastasis, with advanced lung metastasis frequently occurring and being among the primary causes of mortality. MicroRNAs (miR) serve a significant role in the initiation and development of cancer and may be tumour‑specific molecular targets. However, the role of miR...
Source: International Journal of Oncology - May 25, 2020 Category: Cancer & Oncology Authors: Fu M, Chen CW, Yang LQ, Yang WW, Du ZH, Li YR, Li SL, Ge XY Tags: Int J Oncol Source Type: research

Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo.
Abstract Cervical cancer is the fourth most common gynecological malignancy affecting the health of women worldwide and the second most common cause of cancer‑related mortality among women in developing regions. Thus, the development of effective chemotherapeutic drugs for the treatment of cervical cancer has become an important issue in the medical field. The application of natural products for the prevention and treatment of various diseases, particularly cancer, has always attracted widespread attention. In the present study, a library of natural products composed of 78 single compounds was screened and ...
Source: International Journal of Oncology - May 25, 2020 Category: Cancer & Oncology Authors: Gan H, Qi M, Chan C, Leung P, Ye G, Lei Y, Liu A, Xue F, Liu D, Ye W, Zhang D, Deng L, Chen J Tags: Int J Oncol Source Type: research

The TLR4/ERK/PD ‑L1 axis may contribute to NSCLC initiation.
In conclusion, data from the present study suggest that TLR4 and PD‑L1 expression can serve as important prognostic factors for NSCLC, where TLR4 activation may induce PD‑L1 expression through the ERK signaling pathway. PMID: 32468028 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Kang X, Li P, Zhang C, Zhao Y, Hu H, Wen G Tags: Int J Oncol Source Type: research

Doxorubicin and CD ‑CUR inclusion complex co‑loaded in thermosensitive hydrogel PLGA‑PEG‑PLGA localized administration for osteosarcoma.
Doxorubicin and CD‑CUR inclusion complex co‑loaded in thermosensitive hydrogel PLGA‑PEG‑PLGA localized administration for osteosarcoma. Int J Oncol. 2020 May 19;: Authors: Yang Z, Liu J, Lu Y Abstract Combination therapy is a promising and prevalent strategy for osteosarcoma treatment. Curcumin (CUR), as a chemosensitizer, improves the antitumor effect of first‑line chemotherapy drugs. However, due to its poor solubility and instability in physiological conditions, the bioavailability of CUR is limited. In order to improve the physicochemical properties of natural CUR, β‑cyclodextrin ...
Source: International Journal of Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Yang Z, Liu J, Lu Y Tags: Int J Oncol Source Type: research

Artificial intelligence radiogenomics for advancing precision and effectiveness in oncologic care (Review).
Abstract The new era of artificial intelligence (AI) has introduced revolutionary data‑driven analysis paradigms that have led to significant advancements in information processing techniques in the context of clinical decision‑support systems. These advances have created unprecedented momentum in computational medical imaging applications and have given rise to new precision medicine research areas. Radiogenomics is a novel research field focusing on establishing associations between radiological features and genomic or molecular expression in order to shed light on the underlying disease mechanisms and ...
Source: International Journal of Oncology - May 11, 2020 Category: Cancer & Oncology Authors: Trivizakis E, Papadakis GZ, Souglakos I, Papanikolaou N, Koumakis L, Spandidos DA, Tsatsakis A, Karantanas AH, Marias K Tags: Int J Oncol Source Type: research

High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
Abstract Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, co‑inhibitory immune checkpoints can inactivate TILs. The aim of the present study was to examine the association between the TIL load, the mutation rate and the clinical outcome in the immune landscape of patients with CRC. RNA‑seq and whole exome seq data of 453 colon adenocarcinomas (COAD) and rectal adenocarcinomas (READ), along with the TIL load and clinicopathological info...
Source: International Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Authors: Kitsou M, Ayiomamitis GD, Zaravinos A Tags: Int J Oncol Source Type: research

Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia ‑1‑dependent manner.
Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner. Int J Oncol. 2020 May 07;: Authors: Han JM, Hong KO, Yang IH, Ahn CH, Jin B, Lee W, Jung YC, Kim KA, Shin JA, Cho SD, Hong SD Abstract Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been reported to exhibit anticancer activities in several tumors. The aim of the present study was to investigate the anticancer effects and molecular mechanisms of oridonin in mucoepidermoid carcinoma (MEC). Treatment with oridonin induced the apoptosis of MC‑3 and YD‑15 cell ...
Source: International Journal of Oncology - May 7, 2020 Category: Cancer & Oncology Authors: Han JM, Hong KO, Yang IH, Ahn CH, Jin B, Lee W, Jung YC, Kim KA, Shin JA, Cho SD, Hong SD Tags: Int J Oncol Source Type: research

Characterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer.
Abstract The aim of the present study was to identify novel prognostic biomarkers and therapeutic targets for breast cancer; thus, genes that are frequently overexpressed in several types of breast cancer were screened. Kinesin family member 20A (KIF20A) was identified as a candidate molecule during this process. Immunohistochemical staining performed using tissue microarrays from 257 samples of different breast cancer subtypes revealed that KIF20A was expressed in 195 (75.9%) of these samples, whereas it was seldom expressed in normal breast tissue. KIF20A protein was expressed in all types of brea...
Source: International Journal of Oncology - May 7, 2020 Category: Cancer & Oncology Authors: Nakamura M, Takano A, Thang PM, Tsevegjav B, Zhu M, Yokose T, Yamashita T, Miyagi Y, Daigo Y Tags: Int J Oncol Source Type: research

Cytotoxic drugs in combination with the CXCR4 antagonist AMD3100 as a potential treatment option for pediatric rhabdomyosarcoma.
Seitz G Abstract Rhabdomyosarcoma (RMS) is the most common type of pediatric soft tissue sarcoma. The prognosis of advanced stage RMS remains poor, and metastatic invasion is a major cause of treatment failure. Therefore, there is an urgent need for treatment alternatives focusing on metastatic invasion and drug resistance. The stromal cell‑derived factor‑1 (SDF‑1)/chemokine receptor 4 (CXCR4) axis is a crucial factor for metastatic invasion in RMS. Clinical data has revealed that high CXCR4 expression is associated with a poor outcome and a high metastatic rate in several malignancies, includ...
Source: International Journal of Oncology - May 5, 2020 Category: Cancer & Oncology Authors: Regenbogen S, Stagno MJ, Schleicher S, Schilbach K, Bösmüller H, Fuchs J, Schmid E, Seitz G Tags: Int J Oncol Source Type: research

HSulf ‑1 and palbociclib exert synergistic antitumor effects on RB‑positive triple‑negative breast cancer.
HSulf‑1 and palbociclib exert synergistic antitumor effects on RB‑positive triple‑negative breast cancer. Int J Oncol. 2020 May 04;: Authors: Chen F, Zhang Z, Yu Y, Liu Q, Pu F Abstract Human sulfatase‑1 (HSulf‑1) is emerging as a novel prognostic biomarker in breast cancer. Previous studies demonstrated HSulf‑1 to function as a negative regulator of cyclin D1 in breast cancer. Accumulating preclinical evidence is supporting the efficacy of cyclin‑dependent kinase (CDK) 4/6 inhibitors against the luminal androgen receptor sub‑type of triple‑negative breast cancer (TNBC). It was there...
Source: International Journal of Oncology - May 4, 2020 Category: Cancer & Oncology Authors: Chen F, Zhang Z, Yu Y, Liu Q, Pu F Tags: Int J Oncol Source Type: research

Activin A triggers angiogenesis via regulation of VEGFA and its overexpression is associated with poor prognosis of oral squamous cell carcinoma.
ner E, Coletta RD Abstract Poor prognosis associated with the dysregulated expression of activin A in a number of malignancies has been related to with numerous aspects of tumorigenesis, including angiogenesis. The present study investigated the prognostic significance of activin A immunoexpression in blood vessels and cancer cells in a number of oral squamous cell carcinoma (OSCC) cases and applied in vitro strategies to determine the impact of activin A on angiogenesis. In a cohort of 95 patients with OSCC, immunoexpression of activin A in both blood vessels and tumor cells was quantified and the assoc...
Source: International Journal of Oncology - May 4, 2020 Category: Cancer & Oncology Authors: Ervolino De Oliveira C, Rocha Dourado M, Sawazaki-Calone Í, Costa De Medeiros M, Rossa Júnior C, De Karla Cervigne N, Esquiche León J, Lambert D, Salo T, Graner E, Coletta RD Tags: Int J Oncol Source Type: research

Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma.
Abstract Multiple myeloma (MM) is a plasma cell‑associated cancer and accounts for 13% of all hematological malignancies, worldwide. MM still remains an incurable plasma cell malignancy with a poor prognosis due to a lack of suitable markers. Therefore, discovering novel markers and targets for diagnosis and therapeutics of MM is essential. The present study aims to identify markers associated with MM malignancy using patient‑derived MM mononuclear cells (MNCs). Label‑free quantitative proteomics analysis revealed a total of 192 differentially regulated proteins, in which 79 proteins were upre...
Source: International Journal of Oncology - April 29, 2020 Category: Cancer & Oncology Authors: Chanukuppa V, Paul D, Taunk K, Chatterjee T, Sharma S, Shirolkar A, Islam S, Santra MK, Rapole S Tags: Int J Oncol Source Type: research

miR ‑508‑3p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7.
miR‑508‑3p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7. Int J Oncol. 2020 Apr 27;: Authors: Guo F, Zhang K, Li M, Cui L, Liu G, Yan Y, Tian W, Teng F, Zhang Y, Gao C, Gao J, Wang Y, Xue F Abstract Ovarian cancer is the most lethal gynecological tumor, and the 5‑year survival rate is only ~40%. The poor survival rate is due to cancer diagnosis at an advanced stage, when the tumor has metastasized. A better understanding of the molecular pathogenesis of tumor growth and metastasis is needed to improve patient prognosis. MicroRNAs (miRs) regulate carcinogenesis ...
Source: International Journal of Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Guo F, Zhang K, Li M, Cui L, Liu G, Yan Y, Tian W, Teng F, Zhang Y, Gao C, Gao J, Wang Y, Xue F Tags: Int J Oncol Source Type: research

Inhibiting the NF- κB pathway enhances the antitumor effect of cabazitaxel by downregulating Bcl-2 in pancreatic cancer.
In conclusion, results from our previous study indicated that CTX could potentially replace PTX in the treatment of PC, and the present study demonstrated that CTX combination with an NF‑κB inhibitor may be considered as a potential therapeutic option for PC, which may improve the prognosis of patients with PC. PMID: 32377719 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Li Z, Xuan Z, Chen J, Song W, Zhang S, Jin C, Zhou M, Zheng S, Song P Tags: Int J Oncol Source Type: research

Circular RNA is a popular molecule in tumors of the digestive system (Review).
Abstract Most tumors of the digestive system, including esophageal, gastric, liver and colorectal cancer, are malignant tumors that are associated with rates of high morbidity and mortality. The lack of effective methods for early diagnosis is an important cause of poor prognosis for these malignancies. Circular RNAs (circRNAs) belong to a family of endogenous, covalently closed non‑coding RNAs that are characterized as having no 5' cap structures or 3' poly‑A tails. Shortly following discovery, circRNAs were considered to be a product of mis‑splicing and have no significant biological function. However, in ...
Source: International Journal of Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Wang HY, Wang YP, Zeng X, Zheng Y, Guo QH, Ji R, Zhou YN Tags: Int J Oncol Source Type: research

Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis.
Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis. Int J Oncol. 2020 Apr 23;: Authors: Li J, Yin P, Chen X, Kong X, Zhong W, Ge Y, She Y, Xian X, Qi L, Lin Z, Moe J, Fang S Abstract Advanced osteoradionecrosis (ORN) is one of the most serious complications in patients with head and neck cancer, resulting in poor prognosis. Numerous studies have therefore focused on the pathogenesis and interventions of ORN early stage. The present study aimed to investigate whether α2‑macroglobulin (α2M) could prevent early‑stage jaw osteoradionecrosis caused by radio...
Source: International Journal of Oncology - April 23, 2020 Category: Cancer & Oncology Authors: Li J, Yin P, Chen X, Kong X, Zhong W, Ge Y, She Y, Xian X, Qi L, Lin Z, Moe J, Fang S Tags: Int J Oncol Source Type: research

Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl ‑2 in acute myeloid leukaemia MOLM‑13 cells with reduced Beclin 1 expression.
Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl‑2 in acute myeloid leukaemia MOLM‑13 cells with reduced Beclin 1 expression. Int J Oncol. 2020 Apr 23;: Authors: Vu M, Kassouf N, Ofili R, Lund T, Bell C, Appiah S Abstract The overexpression of anti‑apoptotic Bcl‑2 in acute myeloid leukaemia (AML) may contribute to difficulties in eradicating these cells during chemotherapy. In the present study, doxorubicin (Dox) was evaluated for its potential to induce selective apoptotic cell death in AML MOLM‑13 cells and to modulate autophagy through B...
Source: International Journal of Oncology - April 23, 2020 Category: Cancer & Oncology Authors: Vu M, Kassouf N, Ofili R, Lund T, Bell C, Appiah S Tags: Int J Oncol Source Type: research

circRNA_001275 upregulates Wnt7a expression by competitively sponging miR ‑370‑3p to promote cisplatin resistance in esophageal cancer.
circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer. Int J Oncol. 2020 Apr 22;: Authors: Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH, Xu S Abstract Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin‑resistant esophageal cancer. Three pairs of cisplatin‑resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, ...
Source: International Journal of Oncology - April 22, 2020 Category: Cancer & Oncology Authors: Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH, Xu S Tags: Int J Oncol Source Type: research

Advances in circular RNAs and their role in glioma (Review).
Abstract Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High‑grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non‑coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gra...
Source: International Journal of Oncology - April 16, 2020 Category: Cancer & Oncology Authors: Zhang Y, Lin X, Geng X, Shi L, Li Q, Liu F, Fang C, Wang H Tags: Int J Oncol Source Type: research

Role of noncoding RNAs in cholangiocarcinoma (Review).
Abstract Cholangiocarcinoma (CCA) is a malignant tumour originating from biliary epithelial cells, and is increasing in incidence. Radical surgery is the main treatment. However, the pathogenesis of CCA is unclear. Noncoding RNAs (ncRNAs) are non‑protein‑coding RNAs produced by genomic transcription that include microRNAs (miRNAs), circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs). They play important roles in gene expression, epigenetic modification, cell proliferation, differentiation and reproduction. ncRNAs also serve key roles in cancer development. Numerous studies have been carried out on ncRNA...
Source: International Journal of Oncology - April 15, 2020 Category: Cancer & Oncology Authors: Lv Y, Wang Z, Zhao K, Zhang G, Huang S, Zhao Y Tags: Int J Oncol Source Type: research

Upregulated expression of SAC3D1 is associated with progression in gastric cancer.
Abstract SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple datasets from public databases. The protein expression level of SAC3D1 in GC and normal tissues was assessed by an in‑house immunohistochemistry (IHC). The association between SAC3D1 expression and some clinical parameters was assessed based on the TCGA and IHC data. Survi...
Source: International Journal of Oncology - April 15, 2020 Category: Cancer & Oncology Authors: Liu AG, Zhong JC, Chen G, He RQ, He YQ, Ma J, Yang LH, Wu XJ, Huang JT, Li JJ, Mo WJ, Qin XG Tags: Int J Oncol Source Type: research

Knockdown of GSG2 inhibits prostate cancer progression in  vitro and in vivo.
Knockdown of GSG2 inhibits prostate cancer progression in vitro and in vivo. Int J Oncol. 2020 Apr 13;: Authors: Yu F, Lin Y, Xu X, Liu W, Tang D, Zhou X, Wang G, Zheng Y, Xie A Abstract Prostate cancer (PCa) is the second leading cause of cancer‑related death among men worldwide. The present study aimed to investigate the role of germ cell‑specific gene 2 protein (GSG2), also termed histone H3 phosphorylated by GSG2 at threonine‑3, in the development and progression of PCa. GSG2 expression levels in PCa tissues and para‑carcinoma tissues was detected by immunohistochemistry. Th...
Source: International Journal of Oncology - April 13, 2020 Category: Cancer & Oncology Authors: Yu F, Lin Y, Xu X, Liu W, Tang D, Zhou X, Wang G, Zheng Y, Xie A Tags: Int J Oncol Source Type: research

lncRNA LA16c ‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity.
lncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity. Int J Oncol. 2020 Apr 13;: Authors: Xin W, Zhao S, Han X, Zhao P, Yu H, Gao X, Li P, Wu Q, Ding J, Hua K Abstract The aim of the present study was to determine the competitive endogenous RNA (ceRNA) network associated with long‑coding RNA (lncRNA) LA16c‑313D11.11 in endometrial cancer (EC). Initially, the expression levels of LA16c‑313D11.11 in 60 EC tissues, 20 atypical hyperplasia endometrium (EAH) tissues and 20&n...
Source: International Journal of Oncology - April 13, 2020 Category: Cancer & Oncology Authors: Xin W, Zhao S, Han X, Zhao P, Yu H, Gao X, Li P, Wu Q, Ding J, Hua K Tags: Int J Oncol Source Type: research

Gli2 mediates the development of castration ‑resistant prostate cancer.
In conclusion, to the best of our knowledge, the present study was the first occasion in which the essential role of Gli2 in the development of CRPC was demonstrated, providing a potential therapeutic target for the intervention of CRPC. PMID: 32319599 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 13, 2020 Category: Cancer & Oncology Authors: Xia L, Bouamar H, Gu X, Zeballos C, Qin T, Wang B, Zhou Y, Wang Y, Yang J, Zhu H, Zhang W, Houghton PJ, Sun LZ Tags: Int J Oncol Source Type: research

ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma.
Abstract Spinal metastasis occurs in 50‑75% of bone metastases caused by hepatocellular carcinoma (HCC), and HCC‑derived spinal metastasis can lead to a less favorable prognosis. Recently, several studies have demonstrated that C‑X3‑C motif chemokine ligand 1 (CX3CL1) is closely associated with cancer metastasis, and its secretion is modulated by a disintegrin and metalloproteinase 17 (ADAM17). Bone marrow endothelial cells (BMECs) are an essential component of bone marrow. However, little is known about the roles in and effects of BMECs on HCC spinal metastasis. The present study ...
Source: International Journal of Oncology - April 13, 2020 Category: Cancer & Oncology Authors: Sun C, Hu A, Wang S, Tian B, Jiang L, Liang Y, Wang H, Dong J Tags: Int J Oncol Source Type: research

CD38 is involved in cell energy metabolism via activating the PI3K/AKT/mTOR signaling pathway in cervical cancer cells.
In conclusion, the results of the present study suggested that CD38 regulates the metabolism of cervical cancer cells by regulating the PI3K/AKT/mTOR pathway, which may be a candidate target for the treatment of cervical cancer. PMID: 32319590 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Authors: Liao S, Liang L, Yue C, He J, He Z, Jin X, Luo G, Zhou Y Tags: Int J Oncol Source Type: research

G6PD facilitates clear cell renal cell carcinoma invasion by enhancing MMP2 expression through ROS ‑MAPK axis pathway.
In conclusion, the present study demonstrated that G6PD may facilitate ccRCC cell invasive ability by enhancing MMP2 expression through ROS‑MAPK axis pathway. PMID: 32319593 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Authors: Zhang Q, Han Q, Yang Z, Ni Y, Agbana YL, Bai H, Yi Z, Yi X, Kuang Y, Zhu Y Tags: Int J Oncol Source Type: research

Immunological potential of tertiary lymphoid structures surrounding the primary tumor in gastric cancer.
Abstract Tertiary lymphoid structures (TLSs), which consist of B cells, T cells, follicular dendritic cells and high endothelial venules, have recently been found to be associated with effective antitumor immune responses in patients with cancer. Tumor‑infiltrating T cells and B cells have each been demonstrated to be associated with survival in patients with cancer. We hypothesized that TLSs, an assembly of immune cells, may be important for the initiation and/or maintenance of T cell and B cell responses against tumors. The aim of the present study was to examine the cellular mech...
Source: International Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Authors: Yamakoshi Y, Tanaka H, Sakimura C, Deguchi S, Mori T, Tamura T, Toyokawa T, Muguruma K, Hirakawa K, Ohira M Tags: Int J Oncol Source Type: research

CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
A, García-Carrancá A Abstract A common characteristic of cancer types associated with viruses is the dysregulated expression of the CDH1 gene, which encodes E‑cadherin, in general by activation of DNA methyltransferases (Dnmts). In cervical cancer, E7 protein from high risk human papillomaviruses (HPVs) has been demonstrated to interact with Dnmt1 and histone deacetylase type 1 (HDAC1). The present study proposed that E7 may regulate the expression of CDH1 through two pathways: i) Epigenetic, including DNA methylation; and ii) Epigenetic‑independent, including the induction o...
Source: International Journal of Oncology - April 6, 2020 Category: Cancer & Oncology Authors: Rosendo-Chalma P, Antonio-Vejar V, Bigoni-Ordóñez GD, Patiño-Morales CC, Cano-García A, García-Carrancá A Tags: Int J Oncol Source Type: research

Identification of the cis ‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling.
Identification of the cis‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling. Int J Oncol. 2020 Apr 03;: Authors: Rees JS, Cheung LCC, Hamaia SW, Davies G, Sandercock A, Lilley KS, Tigue N, Jackson AP Abstract The immune checkpoint protein B7‑H4 plays an important role in the positive as well as the negative regulation of immune T‑cell responses. When expressed on cancer cells, B7‑H4 inhibits T‑cell activity, and numerous types of cancer cells use upregulation of B7‑H4 as a survival strategy....
Source: International Journal of Oncology - April 3, 2020 Category: Cancer & Oncology Authors: Rees JS, Cheung LCC, Hamaia SW, Davies G, Sandercock A, Lilley KS, Tigue N, Jackson AP Tags: Int J Oncol Source Type: research

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1 ‑AKT/ERK‑Snail signaling pathway.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway. Int J Oncol. 2020 Apr 03;: Authors: Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D Abstract Cyclovirobuxine D (CVB‑D) is an alkaloid, which is mainly derived from Buxus microphylla. It has been reported that CVB‑D has positive effects on breast cancer, gastric cancer and other malignant tumors. However, to the best of our knowledge, there are no reports regarding the effects of CVB‑D on colorectal cancer (CRC). The purpose of the present study was to determine the anticancer...
Source: International Journal of Oncology - April 3, 2020 Category: Cancer & Oncology Authors: Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D Tags: Int J Oncol Source Type: research

Tetramethylpyrazine reduces prostate cancer malignancy through inactivation of the DPP10 ‑AS1/CBP/FOXM1 signaling pathway.
In conclusion, the present study showed that TMP may be a promising treatment agent for PCa and lncRNA DPP10‑AS1 may be a promising therapeutic target for TMP treatment. PMID: 32319592 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 1, 2020 Category: Cancer & Oncology Authors: Zhou Y, Zhou Z, Ji Z, Yan W, Li H, Yu X Tags: Int J Oncol Source Type: research

Progress and prospects of biomarkers in  primary liver cancer (Review).
Progress and prospects of biomarkers in primary liver cancer (Review). Int J Oncol. 2020 Apr 01;: Authors: Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN, Chen DX Abstract Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation, recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most common malignant tumors; it has high incidence and mortality rates and seriously endangers human health. The main pathological types of primary liver cancer include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and comb...
Source: International Journal of Oncology - April 1, 2020 Category: Cancer & Oncology Authors: Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN, Chen DX Tags: Int J Oncol Source Type: research

Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
Abstract The post‑translational modification of proteins by ubiquitinating enzymes plays a central role in a number of cellular functions, such as cell proteolysis, DNA repair, and cell signaling and communication. Deubiquitinating enzymes (DUBs) disassemble ubiquitin chains and remove ubiquitin moieties from proteins. Targeting DUBs in cancer models has revealed an important role for these enzymes in tumorigenesis, and they therefore have emerged as attractive therapeutic targets. In the present study, the effects of three DUB inhibitors, PR‑619, RA‑9 and LDN‑91946, on a non‑small cell lung cancer cell ...
Source: International Journal of Oncology - April 1, 2020 Category: Cancer & Oncology Authors: Mirzapoiazova T, Pozhitkov A, Nam A, Mambetsariev I, Nelson MS, Tan YC, Zhang K, Raz D, Singhal S, Nasser MW, Kulkarni P, Batra SK, Sattler M, Salgia R Tags: Int J Oncol Source Type: research

Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway.
Abstract Osteosarcoma is the most common primary malignant tumor of the bone and the long‑term survival of patients with this disease has remained unsatisfactory over the past several decades. Andrographolide, a traditional drug used in Chinese medicine, has been found to exert a significant antitumor effect against several types of cancer. However, relatively little is known about the effect of andrographolide on osteosarcoma and the underlying mechanisms. In the present study, it was shown that andrographolide inhibited osteosarcoma cell proliferation by arresting the cell cycle at the G2/M phase and increasin...
Source: International Journal of Oncology - March 30, 2020 Category: Cancer & Oncology Authors: Wang S, Li H, Chen S, Wang Z, Yao Y, Chen T, Ye Z, Lin P Tags: Int J Oncol Source Type: research

Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long ‑term BRAF inhibition.
Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long‑term BRAF inhibition. Int J Oncol. 2020 Mar 30;: Authors: Madorsky Rowdo FP, Barón A, Gallagher SJ, Hersey P, Emran AA, Von Euw EM, Barrio MM, Mordoh J Abstract It is estimated that ~50% of patients with melanoma harbour B‑Raf (BRAF)V600 driver mutations, with the most common of these being BRAFV600E, which leads to the activation of mitogen‑activated protein kinase proliferative and survival pathways. BRAF inhibitors are used extensively to treat BRAF‑mutated metastatic melanoma; however, acquired resi...
Source: International Journal of Oncology - March 30, 2020 Category: Cancer & Oncology Authors: Madorsky Rowdo FP, Barón A, Gallagher SJ, Hersey P, Emran AA, Von Euw EM, Barrio MM, Mordoh J Tags: Int J Oncol Source Type: research

Clinical efficacy of decitabine ‑containing induction chemotherapy in de novo non‑elderly acute myeloid leukemia.
Clinical efficacy of decitabine‑containing induction chemotherapy in de novo non‑elderly acute myeloid leukemia. Int J Oncol. 2020 Mar 30;: Authors: Zheng L, Huang L, Hui Y, Huang L, Li Y, Shang Z, Wei J, Wang Z, Mao X, Wang Y, Xiao M, Zhang D Abstract To improve the complete response rate (CRR) and reduce the recurrence rate of newly diagnosed non‑elderly acute myeloid leukemia (AML), the present study compared the clinical efficacy of decitabine with cytarabine (A) and daunorubicin (D)‑based remission induction therapy with D + A‑based remission induction therapy. ...
Source: International Journal of Oncology - March 30, 2020 Category: Cancer & Oncology Authors: Zheng L, Huang L, Hui Y, Huang L, Li Y, Shang Z, Wei J, Wang Z, Mao X, Wang Y, Xiao M, Zhang D Tags: Int J Oncol Source Type: research

Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review).
Abstract Bone morphogenetic proteins (BMP) are pluripotent molecules, co‑ordinating cellular functions from early embryonic and postnatal development to tissue repair, regeneration and homeostasis. They are also involved in tumourigenesis, disease progression and the metastasis of various solid tumours. Emerging evidence has indicated that BMPs are able to promote disease progression and metastasis by orchestrating communication between cancer cells and the surrounding microenvironment. The interactions occur between BMPs and epidermal growth factor receptor, hepatocyte growth factor, fibroblast growth factor, v...
Source: International Journal of Oncology - March 26, 2020 Category: Cancer & Oncology Authors: Sun Z, Cai S, Zabkiewicz C, Liu C, Ye L Tags: Int J Oncol Source Type: research

Role of fibroblast growth factor 4 in the growth and metastasis of colorectal cancer.
Abstract The role of fibroblast growth factor receptor 4 (FGFR4) in colorectal cancer (CRC) is poorly characterized. Therefore, the objective of the current study was to investigate the expression levels of FGFR4 in colorectal cancer and its prognostic value, and clarify the role of FGFR4 in the proliferation and metastasis of colorectal cancer cells. Immunohistochemistry was used to detect the association between FGFR4 expression and clinicopathological features in colorectal cancer tissues. The effect of FGFR4 silencing on tumor cell proliferation, cell cycle, apoptosis, migration and invasion was evaluated...
Source: International Journal of Oncology - March 26, 2020 Category: Cancer & Oncology Authors: Ye Y, Jiang D, Li J, Han C, Wang X, Wang F, Li J Tags: Int J Oncol Source Type: research

Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy.
In conclusion, these findings suggested that NTF4 may be a diagnostic marker associated with the overall survival and progression of patients with CRC. NTF4 was found to promote tumorigenesis and CRC development through autophagy regulation. PMID: 32236587 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - March 26, 2020 Category: Cancer & Oncology Authors: Yang Z, Chen Y, Wei X, Wu D, Min Z, Quan Y Tags: Int J Oncol Source Type: research

Expression and secretion of the pro ‑inflammatory cytokine IL‑8 is increased in colorectal cancer cells following the knockdown of non‑erythroid spectrin αII.
Expression and secretion of the pro‑inflammatory cytokine IL‑8 is increased in colorectal cancer cells following the knockdown of non‑erythroid spectrin αII. Int J Oncol. 2020 Mar 26;: Authors: Ackermann A, Lafferton B, Plotz G, Zeuzem S, Brieger A Abstract Non‑erythroid spectrin αII (SPTAN1) expression is decreased in ~40% of cases of MLH1‑deficient colorectal cancer (CRC). SPTAN1 knockdown reduces cell viability, cellular mobility and cell‑cell contact formation, indicating that the SPTAN1 plays an important role in tumour growth, attachment and in regulating the tumour micro...
Source: International Journal of Oncology - March 26, 2020 Category: Cancer & Oncology Authors: Ackermann A, Lafferton B, Plotz G, Zeuzem S, Brieger A Tags: Int J Oncol Source Type: research

Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.
Abstract In total, ~85% of malignant gastrointestinal stromal tumours (GISTs) harbour activating mutations in one of the genes KIT or PDGFRA, while 10‑15% of all GISTs have no detectable KIT or PDGFRA mutations, but could have alterations in genes of the succinate dehydrogenase complex or in BRAF, PIK3CA or rarely RAS family genes. The clinical benefit of tyrosine kinase inhibitors, such as imatinib, depends on the GIST genotype, therefore molecular characterization of GIST has a crucial role in overall management of GIST. The aim of the present study was to molecularly characterize a cohort of 70 ...
Source: International Journal of Oncology - March 26, 2020 Category: Cancer & Oncology Authors: Bombac A, Zakotnik B, Bucic M, Setrajcic Dragos V, Gazic B, Stegel V, Klancar G, Novakovic S Tags: Int J Oncol Source Type: research

CDKN1A upregulation and cisplatin ‑pemetrexed resistance in non‑small cell lung cancer cells.
CDKN1A upregulation and cisplatin‑pemetrexed resistance in non‑small cell lung cancer cells. Int J Oncol. 2020 Mar 24;: Authors: Zamagni A, Pasini A, Pirini F, Ravaioli S, Giordano E, Tesei A, Calistri D, Ulivi P, Fabbri F, Foca F, Delmonte A, Molinari C Abstract Cisplatin‑pemetrexed is a frequently adopted first‑line treatment for patients with advanced non‑small cell lung cancer (NSCLC) ineligible for biological therapy, notwithstanding its limited efficacy. In the present study, the RAL cell line, an epidermal growth factor receptor (EGFR)‑wild‑type, p53‑ and KRAS‑mutated model of...
Source: International Journal of Oncology - March 24, 2020 Category: Cancer & Oncology Authors: Zamagni A, Pasini A, Pirini F, Ravaioli S, Giordano E, Tesei A, Calistri D, Ulivi P, Fabbri F, Foca F, Delmonte A, Molinari C Tags: Int J Oncol Source Type: research

Cancer cell ‑specific anticancer effects of Coptis chinensis on gefitinib‑resistant lung cancer cells are mediated through the suppression of Mcl‑1 and Bcl‑2.
Cancer cell‑specific anticancer effects of Coptis chinensis on gefitinib‑resistant lung cancer cells are mediated through the suppression of Mcl‑1 and Bcl‑2. Int J Oncol. 2020 Mar 24;: Authors: Kim JH, Ko ES, Kim D, Park SH, Kim EJ, Rho J, Seo H, Kim MJ, Yang WM, Ha IJ, Park MJ, Lee JY Abstract The epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitor (TKI), gefitinib, is an effective therapeutic drug used in the treatment of non‑small cell lung cancers (NSCLCs) harboring EGFR mutations. However, acquired resistance significantly limits the efficacy of EGFR‑TKIs and cons...
Source: International Journal of Oncology - March 24, 2020 Category: Cancer & Oncology Authors: Kim JH, Ko ES, Kim D, Park SH, Kim EJ, Rho J, Seo H, Kim MJ, Yang WM, Ha IJ, Park MJ, Lee JY Tags: Int J Oncol Source Type: research

Long non ‑coding RNA ZEB1‑AS1 predicts a poor prognosis and promotes cancer progression through the miR‑200a/ZEB1 signaling pathway in intrahepatic cholangiocarcinoma.
Long non‑coding RNA ZEB1‑AS1 predicts a poor prognosis and promotes cancer progression through the miR‑200a/ZEB1 signaling pathway in intrahepatic cholangiocarcinoma. Int J Oncol. 2020 Mar 20;: Authors: Jiao M, Ning S, Chen J, Chen L, Jiao M, Cui Z, Guo L, Mu W, Yang H Abstract Emerging evidence suggests that long non‑coding RNAs (lncRNAs) play pivotal roles in cancer progression, including in intrahepatic cholangiocarcinoma (IHCC). The overexpression of lncRNA ZEB1 antisense 1 (ZEB1‑AS1) has been discovered in several types of cancer; however, the clinical significance and functional role o...
Source: International Journal of Oncology - March 20, 2020 Category: Cancer & Oncology Authors: Jiao M, Ning S, Chen J, Chen L, Jiao M, Cui Z, Guo L, Mu W, Yang H Tags: Int J Oncol Source Type: research