Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T ‑cell lymphoma expressing the ITK‑SYK fusion gene.
Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T‑cell lymphoma expressing the ITK‑SYK fusion gene. Int J Oncol. 2019 Sep 20;: Authors: Zhang LL, Pan HX, Wang YX, Guo T, Liu L Abstract Peripheral T‑cell lymphomas (PTCLs) are heterogeneous malignancies that are types of non‑Hodgkin lymphomas; patients with this disease have poor prognoses. The IL‑2‑inducible T‑cell kinase‑spleen tyrosine kinase (ITK‑SYK) fusion gene, the first recurrent chromosome translocation in PTCL‑not otherwise specified (NOS), can drive cellular transformation and the development of ...
Source: International Journal of Oncology - September 20, 2019 Category: Cancer & Oncology Authors: Zhang LL, Pan HX, Wang YX, Guo T, Liu L Tags: Int J Oncol Source Type: research

Role of evaluating tumor ‑infiltrating lymphocytes, programmed death‑1 ligand 1 and mismatch repair proteins expression in malignant mesothelioma.
Role of evaluating tumor‑infiltrating lymphocytes, programmed death‑1 ligand 1 and mismatch repair proteins expression in malignant mesothelioma. Int J Oncol. 2019 Sep 20;: Authors: Losi L, Bertolini F, Guaitoli G, Fabbiani L, Banchelli F, Ambrosini-Spaltro A, Botticelli L, Scurani L, Baldessari C, Barbieri F, Cascinu S, Maiorana A Abstract The tumor immune microenvironment (TME) and immune checkpoints have been reported to serve a role in the pathogenesis of malignant mesothelioma (MM) and treatment outcome. Additionally, mismatch Repair (MMR) deficiency appears to enhance the response to checkpo...
Source: International Journal of Oncology - September 20, 2019 Category: Cancer & Oncology Authors: Losi L, Bertolini F, Guaitoli G, Fabbiani L, Banchelli F, Ambrosini-Spaltro A, Botticelli L, Scurani L, Baldessari C, Barbieri F, Cascinu S, Maiorana A Tags: Int J Oncol Source Type: research

Sorafenib inhibits vascular endothelial cell proliferation stimulated by anaplastic thyroid cancer cells regardless of BRAF mutation status.
In conclusion, sorafenib more effectively inhibited RAF‑generated growth signals in ATC cells compared with signals generated by its upstream gene, RAS. ATC cells stimulated the growth of HUVECs via humoral factors, including VEGF; this effect was clearly inhibited by sorafenib. The present findings highlighted the potential of sorafenib for the treatment of ATC and provided insight into its mechanism of action. PMID: 31545405 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - September 19, 2019 Category: Cancer & Oncology Authors: Ishihara S, Onoda N, Noda S, Asano Y, Tauchi Y, Morisaki T, Kashiwagi S, Takashima T, Ohira M Tags: Int J Oncol Source Type: research

MicroRNA ‑133b targets TGFβ receptor I to inhibit TGF‑β‑induced epithelial‑to‑mesenchymal transition and metastasis by suppressing the TGF‑β/SMAD pathway in breast cancer.
MicroRNA‑133b targets TGFβ receptor I to inhibit TGF‑β‑induced epithelial‑to‑mesenchymal transition and metastasis by suppressing the TGF‑β/SMAD pathway in breast cancer. Int J Oncol. 2019 Sep 18;: Authors: Wang S, Huang M, Wang Z, Wang W, Zhang Z, Qu S, Liu C Abstract Breast cancer (BC) is one of the most common types of cancer and the leading cause of cancer‑associated mortality among women worldwide. Accumulating evidence indicates that microRNA (miR)‑133b inhibits the proliferation and invasion of cancer cells. Considering that transforming growth factor (TGF)‑&bet...
Source: International Journal of Oncology - September 18, 2019 Category: Cancer & Oncology Authors: Wang S, Huang M, Wang Z, Wang W, Zhang Z, Qu S, Liu C Tags: Int J Oncol Source Type: research

Targeting of EZH2 inhibits epithelial ‑mesenchymal transition in head and neck squamous cell carcinoma via regulating the STAT3/VEGFR2 axis.
In conclusion, we proposed that EZH2 regulates EMT and tumor invasion and metastasis in HNSCC by governing the STAT3/VEGFR2 axis. These findings provide a rationale for developing novel strategies to treat invasive and metastatic HNSCC via targeting the EZH2/STAT3/VEGFR2 pathway. PMID: 31545422 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - September 18, 2019 Category: Cancer & Oncology Authors: Zhao M, Hu X, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Zhang L, Jin R, Zhou X Tags: Int J Oncol Source Type: research

Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.
Abstract Neuroblastoma (NB) is a heterogeneous extra‑cranial childhood type of cancer, responsible for approximately 15% of all paediatric cancer‑related deaths. Although several critical genetic aberrations have been related to NB, only a few established molecular markers have been associated with prognosis [V‑myc avian myelocytomatosis viral oncogene (MYCN) locus amplification, deletions of part of chromosome 1p, 11q23 and gain of 17q]. Regrettably, direct evidence of NB‑related tumour suppressors or oncogenes has not been currently identified at these chromosomal regions. MYCN locus ampli...
Source: International Journal of Oncology - September 13, 2019 Category: Cancer & Oncology Authors: Fratini E, Cervelli M, Mariottini P, Kanamori Y, Amendola R, Agostinelli E Tags: Int J Oncol Source Type: research

Pivotal roles of protein 4.1B/DAL ‑1, a FERM‑domain containing protein, in tumor progression (Review).
Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review). Int J Oncol. 2019 Sep 13;: Authors: Yuan X, Piao L, Wang L, Han X, Zhuang M, Liu Z Abstract Protein 4.1B/DAL‑1, encoded by erythrocyte membrane protein band 4.1‑like 3 (EPB41L3), belongs to the protein 4.1 superfamily, a group of proteins that share a conserved four.one‑ezrin‑radixin‑moesin (FERM) domain. Protein 4.1B/DAL‑1 serves a crucial role in cytoskeletal organization and a number of processes through multiple interactions with membrane proteins via its FERM, spectrin‑actin‑b...
Source: International Journal of Oncology - September 13, 2019 Category: Cancer & Oncology Authors: Yuan X, Piao L, Wang L, Han X, Zhuang M, Liu Z Tags: Int J Oncol Source Type: research

Identification of new cancer stem cell markers and signaling pathways in HER ‑2‑positive breast cancer by transcriptome sequencing.
Identification of new cancer stem cell markers and signaling pathways in HER‑2‑positive breast cancer by transcriptome sequencing. Int J Oncol. 2019 Sep 12;: Authors: Feng L, Huang S, An G, Wang G, Gu S, Zhao X Abstract Human epidermal growth factor receptor (HER)‑2‑positive breast cancer accounts for ~25% of all breast cancer cases, has a high propensity for relapse, metastasis and drug resistance, and is associated with a poor prognosis. Therefore, it is necessary to develop more effective therapeutic targets for the treatment of HER‑2‑positive breast cancer. CD44+/CD24‑/low is current...
Source: International Journal of Oncology - September 12, 2019 Category: Cancer & Oncology Authors: Feng L, Huang S, An G, Wang G, Gu S, Zhao X Tags: Int J Oncol Source Type: research

Silencing the long noncoding RNA, TINCR, a molecular sponge of miR ‑335, inhibits the malignant phenotype of epithelial ovarian cancer via FGF2 suppression.
This study showed, for the first time to the best of our knowledge, that silencing TINCR, which interacts with miR‑335, inhibited EOC progression in vitro and in vivo by decreasing FGF2 expression. Hence, this lncRNA could be a potential prognostic biomarker and effective target for therapeutic intervention in EOC. PMID: 31545411 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - September 10, 2019 Category: Cancer & Oncology Authors: Li R, Wang Y, Xu Y, He X, Li Y Tags: Int J Oncol Source Type: research

[Corrigendum] The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors.
Abstract Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the authors were able to confirm that the data correctly shown for the 'Untreated cells' experiment had inadvertently been included in the Figure as the data for the 'DMSO' experiment. Additionally, in Fig. 2b, the authors noticed that the percentage of untreated cells ...
Source: International Journal of Oncology - September 9, 2019 Category: Cancer & Oncology Authors: Nestal De Moraes G, Pereira Castro C, Salustiano EJ, Dumas ML, Costas F, Wing-Fai Lam E, Ribeiro Costa PR, Maia RC Tags: Int J Oncol Source Type: research

[Corrigendum] CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1.
Abstract Subsequently to the publication of this article, the authors have realized that the order of the corresponding authors in the author list should have been reversed: Wenshu Chai was listed as the penultimate author on the paper, whereas Xianbao Shi should have been featured before Wenshu Chai. Therefore, the authors and affiliations for this paper should have appeared as follows: LINA SHAN1, MINJIE ZHAO1, YA LU1, HONGJUAN NING1, SHUMAN YANG2, YONGGUI SONG3, XIANBAO SHI1 and WENSHU CHAI1 1Department of Respiratory, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001; 2...
Source: International Journal of Oncology - September 6, 2019 Category: Cancer & Oncology Authors: Shan L, Zhao M, Lu Y, Ning H, Yang S, Song Y, Shi X, Chai W Tags: Int J Oncol Source Type: research

Selective uveal melanoma inhibition with calcium channel blockade.
In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify potential UMM‑selective cytotoxic agents. Amlodipine, a dihydropyridine calcium channel blocker (CCB), ranked no. 2 and no. 8 of the most cytotoxic compounds. Thus, we further characterized the differential effects of calcium blockade on UMM and cutaneous malignant melanoma (CMM) lines in vitro using growth inhibition, cell cycle progression, apoptosis and senescence assays. Amlodipine had a significantly higher growth inhibitory potency in UMM (IC50=13.1 &m...
Source: International Journal of Oncology - September 6, 2019 Category: Cancer & Oncology Authors: Shaughnessy M, Lamuraglia G, Klebanov N, Ji Z, Rajadurai A, Kumar R, Flaherty K, Tsao H Tags: Int J Oncol Source Type: research

HBV triggers APOBEC2 expression through miR ‑122 regulation and affects the proliferation of liver cancer cells.
HBV triggers APOBEC2 expression through miR‑122 regulation and affects the proliferation of liver cancer cells. Int J Oncol. 2019 Sep 04;: Authors: Li A, Wu J, Zhai A, Qian J, Wang X, Qaria MA, Zhang Q, Li Y, Fang Y, Kao W, Song W, Zhang Z, Zhang F Abstract Hepatitis B virus (HBV) infection is responsible for 50% of liver cancer cases globally; this disease is one of the leading causes of cancer‑associated mortality. One reported mechanism underlying the development of liver cancer is the mutation of tumor suppressor genes induced by the overexpression of apolipoprotein B mRNA‑editing enzyme cat...
Source: International Journal of Oncology - September 4, 2019 Category: Cancer & Oncology Authors: Li A, Wu J, Zhai A, Qian J, Wang X, Qaria MA, Zhang Q, Li Y, Fang Y, Kao W, Song W, Zhang Z, Zhang F Tags: Int J Oncol Source Type: research

LncRNA NEAT1 enhances the resistance of anaplastic thyroid carcinoma cells to cisplatin by sponging miR ‑9‑5p and regulating SPAG9 expression.
In conclusion, the present study demonstrated that NEAT1 silencing ameliorated DDP‑resistance of ATC, at least in part by reducing miR‑9‑5p sponging and regulating SPAG5 expression; therefore, NEAT1 may be considered a potential therapeutic target of ATC. PMID: 31485599 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - September 4, 2019 Category: Cancer & Oncology Authors: Yan P, Su Z, Zhang Z, Gao T Tags: Int J Oncol Source Type: research

[Corrigendum] USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β‑catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
[Corrigendum] USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β‑catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma. Int J Oncol. 2019 Sep 04;: Authors: Ning Z, Wang A, Liang J, Xie Y, Liu J, Feng L, Yan Q, Wang Z Abstract Subsequently to the publication of the above paper, the authors have realized that Figs. 3 and 4 contained errors. Two sets of bands in Figs. 3D and 4B were erroneously placed during the process of figure preparation. In Fig. 3D, the β‑actin bands for the PANC...
Source: International Journal of Oncology - September 4, 2019 Category: Cancer & Oncology Authors: Ning Z, Wang A, Liang J, Xie Y, Liu J, Feng L, Yan Q, Wang Z Tags: Int J Oncol Source Type: research

Long non ‑coding RNA nuclear paraspeckle assembly transcript 1 interacts with microRNA‑107 to modulate breast cancer growth and metastasis by targeting carnitine palmitoyltransferase‑1.
Long non‑coding RNA nuclear paraspeckle assembly transcript 1 interacts with microRNA‑107 to modulate breast cancer growth and metastasis by targeting carnitine palmitoyltransferase‑1. Int J Oncol. 2019 Sep 04;: Authors: Xiong Y, Liu Z, Li Z, Wang S, Shen N, Xin Y, Huang T Abstract Previous studies revealed that the long non‑coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) exhibits abnormal expression in numerous cancer types, including breast cancer (BC); however, the regulatory mechanism of NEAT1 in BC remains unclear. In the present study, the effect of NEAT1 on the progression ...
Source: International Journal of Oncology - September 4, 2019 Category: Cancer & Oncology Authors: Xiong Y, Liu Z, Li Z, Wang S, Shen N, Xin Y, Huang T Tags: Int J Oncol Source Type: research

Hypoxia ‑induced internalization of connexin 26 and connexin 43 in pulmonary epithelial cells is involved in the occurrence of non‑small cell lung cancer via the P53/MDM2 signaling pathway.
Hypoxia‑induced internalization of connexin 26 and connexin 43 in pulmonary epithelial cells is involved in the occurrence of non‑small cell lung cancer via the P53/MDM2 signaling pathway. Int J Oncol. 2019 Sep 03;: Authors: Zeng SG, Lin X, Liu JC, Zhou J Abstract Reports have highlighted an association between connexins (CXs) or gap junction proteins and non‑small cell lung cancer (NSCLC). In the present study, it was aimed to elucidate the regulatory mechanism of CX26 and CX43 under hypoxic conditions in NSCLC. Clinical samples were collected for analysis of CX26 and CX43 expression and c...
Source: International Journal of Oncology - September 3, 2019 Category: Cancer & Oncology Authors: Zeng SG, Lin X, Liu JC, Zhou J Tags: Int J Oncol Source Type: research

miR ‑5191 functions as a tumor suppressor by targeting RPS6KB1 in colorectal cancer.
miR‑5191 functions as a tumor suppressor by targeting RPS6KB1 in colorectal cancer. Int J Oncol. 2019 Aug 30;: Authors: An HJ, Park M, Kim J, Han YH Abstract MicroRNAs (miRNAs/miRs) are a class of small non‑coding RNAs that play pivotal roles in cancer physiology as important epigenetic regulators of gene expression. Several miRNAs have been previously discovered that regulate the proliferation of the colorectal cancer (CRC) cell line HCT116. In the present study, one of these miRNAs, miR‑5191, was characterized as a tumor suppressor in CRC cells. Transfection with miR‑5191 led to a significan...
Source: International Journal of Oncology - August 30, 2019 Category: Cancer & Oncology Authors: An HJ, Park M, Kim J, Han YH Tags: Int J Oncol Source Type: research

Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. Despite advances in surgery, radiotherapy and chemotherapy, the overall 5‑year survival rate of patients with OSCC has not significantly improved. In addition, the prognosis of patients with advanced‑stage OSCC remains poor. Therefore, it is necessary to develop novel therapeutic modalities. Vincristine (VCR), a naturally occurring vinca alkaloid, is a classical microtubule‑destabilizing agent and is widely used in the treatment of a number of cancers. Despite the proven antitumor benefits of VCR treatment, one of the major ...
Source: International Journal of Oncology - August 30, 2019 Category: Cancer & Oncology Authors: Hsieh MJ, Chen YH, Lee IN, Huang C, Ku YJ, Chen JC Tags: Int J Oncol Source Type: research

ROCK1 promotes migration and invasion of non ‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway.
ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway. Int J Oncol. 2019 Aug 30;: Authors: Hu C, Zhou H, Liu Y, Huang J, Liu W, Zhang Q, Tang Q, Sheng F, Li G, Zhang R Abstract Rho‑associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an important function in cell migration and invasion in neoplasms. ROCK1 has been found to be overexpressed in several types of cancers. However, the role of ROCK1 in non‑small‑cell lung cancer (NSCLC) is poorly understood. In the present study, ROCK1 was found to be overexpressed in NSCLC...
Source: International Journal of Oncology - August 30, 2019 Category: Cancer & Oncology Authors: Hu C, Zhou H, Liu Y, Huang J, Liu W, Zhang Q, Tang Q, Sheng F, Li G, Zhang R Tags: Int J Oncol Source Type: research

Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
In conclusion, these results suggest that Brd4 has great potential as a therapeutic target, and JQ1 has notable anti‑tumor effects against GBM which may be mediated via the VEGF/PI3K/AKT signaling pathway. PMID: 31485609 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - August 29, 2019 Category: Cancer & Oncology Authors: Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L Tags: Int J Oncol Source Type: research

Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma.
In conclusion, JAK2, STAT5A and STAT6 may be potential prognostic biomarkers for HCC. JAK2, TYK2, STAT3, STAT4 and STAT5B may be potential diagnostic biomarkers for HCC. STAT6 has a role in HCC that may be mediated via effects on the cell cycle, cell division and lipid metabolism. PMID: 31485610 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - August 27, 2019 Category: Cancer & Oncology Authors: Wang X, Liao X, Yu T, Gong Y, Zhang L, Huang J, Yang C, Han C, Yu L, Zhu G, Qin W, Liu Z, Zhou X, Liu J, Han Q, Peng T Tags: Int J Oncol Source Type: research

Expression profile ‑driven discovery of AURKA as a treatment target for liposarcoma.
In this study, we reanalyzed two published microarray data sets of LPS. By comparing the top 50 upregulated genes in DD LPS in both sets of data, we identified 12 overlapping genes. Of note, the top five gene sets enriched in DD LPS in both sets of data were involved in cell cycle regulation. Among the 12 overlapping genes, aurora kinase A (AURKA) is a well‑known gene involved in cell cycle regulation; we thus further investigated this gene. AURKA was significantly upregulated in DD LPS, compared with WD LPS. Among 40 cases of DD LPS in GSE30929, patients with high AURKA expression in tumors had significantly worse ...
Source: International Journal of Oncology - August 23, 2019 Category: Cancer & Oncology Authors: Yen CC, Chen SC, Hung GY, Wu PK, Chua WY, Lin YC, Yen CH, Chen YC, Wang JY, Yang MH, Chao Y, Chang MC, Chen WM Tags: Int J Oncol Source Type: research

Characterization of the human zinc finger nfx ‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells.
Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells. Int J Oncol. 2019 Aug 20;: Authors: Hamada H, Yamamura M, Ohi H, Kobayashi Y, Niwa K, Oyama T, Mano Y, Asai M, Tanuma SI, Uchiumi F Abstract Human promyelocytic HL‑60 cells can be differentiated into macrophage‑like cells by treatment with 12‑O‑tetra decanoylphorbol‑13‑acetate (TPA). Certain 5' upstream regions of the zinc finger protein (ZNF)‑encoding genes contain duplicated GGAA motifs, which are frequently found in the T...
Source: International Journal of Oncology - August 20, 2019 Category: Cancer & Oncology Authors: Hamada H, Yamamura M, Ohi H, Kobayashi Y, Niwa K, Oyama T, Mano Y, Asai M, Tanuma SI, Uchiumi F Tags: Int J Oncol Source Type: research

TGFBR2 ‑dependent alterations of microRNA profiles in extracellular vesicles and parental colorectal cancer cells.
TGFBR2‑dependent alterations of microRNA profiles in extracellular vesicles and parental colorectal cancer cells. Int J Oncol. 2019 Aug 19;: Authors: Fricke F, Mussack V, Buschmann D, Hausser I, Pfaffl MW, Kopitz J, Gebert J Abstract In colorectal cancer (CRC) with microsatellite instability (MSI),>90% of cases are affected by inactivating frameshift mutations of transforming growth factor β receptor type 2 (TGFBR2). TGFBR2 deficiency is considered to drive MSI tumor progression by abrogating downstream TGF‑β signaling. This pathway can alter the expression of coding and non‑co...
Source: International Journal of Oncology - August 19, 2019 Category: Cancer & Oncology Authors: Fricke F, Mussack V, Buschmann D, Hausser I, Pfaffl MW, Kopitz J, Gebert J Tags: Int J Oncol Source Type: research

Genome ‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma.
Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma. Int J Oncol. 2019 Aug 14;: Authors: Wang X, Zhou X, Liu J, Liu Z, Zhang L, Gong Y, Huang J, Yu L, Wang Q, Yang C, Liao X, Yu T, Han C, Zhu G, Ye X, Peng T Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of tumor‑related mortalities worldwide. Long noncoding RNAs have been reported to be associated with tumor initiation, progression and prognosis. The present study aimed to explore the association between long non...
Source: International Journal of Oncology - August 14, 2019 Category: Cancer & Oncology Authors: Wang X, Zhou X, Liu J, Liu Z, Zhang L, Gong Y, Huang J, Yu L, Wang Q, Yang C, Liao X, Yu T, Han C, Zhu G, Ye X, Peng T Tags: Int J Oncol Source Type: research

Altered DNA methylation is associated with aberrant stemness gene expression in early ‑stage HNSCC.
Altered DNA methylation is associated with aberrant stemness gene expression in early‑stage HNSCC. Int J Oncol. 2019 Aug 14;: Authors: Suzuki T, Yamazaki H, Honda K, Ryo E, Kaneko A, Ota Y, Mori T Abstract Head and neck squamous cell carcinoma (HNSCC) is characterized by morphological and functional cellular heterogeneity, which are properties of progenitor cells, as opposed to cell alterations caused by accidental expression of stem cell‑related molecules. The expression levels of stemness molecules and their distribution in HNSCC are unclear. As regards sporadic cellular heterogeneity, methylati...
Source: International Journal of Oncology - August 14, 2019 Category: Cancer & Oncology Authors: Suzuki T, Yamazaki H, Honda K, Ryo E, Kaneko A, Ota Y, Mori T Tags: Int J Oncol Source Type: research

Oncological role of HMGA2 (Review).
Abstract The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor that modulates the transcription of several genes by binding to AT‑rich sequences in the minor groove of B‑form DNA and alters the chromatin structure. As a result, HMGA2 influences a variety of biological processes, including the cell cycle process, DNA damage repair process, apoptosis, senescence, epithelial‑mesenchymal transition and telomere restoration. In addition, the overexpression of HMGA2 is a feature of malignancy, and its elevated expression in human cancer predicts the efficacy of certa...
Source: International Journal of Oncology - August 13, 2019 Category: Cancer & Oncology Authors: Zhang S, Mo Q, Wang X Tags: Int J Oncol Source Type: research

Construction and characterization of a truncated tissue factor ‑coagulation‑based composite system for selective thrombosis in tumor blood vessels.
Construction and characterization of a truncated tissue factor‑coagulation‑based composite system for selective thrombosis in tumor blood vessels. Int J Oncol. 2019 Aug 12;: Authors: Xu P, Zou M, Wang S, Li T, Liu C, Wang L, Wang L, Luo F, Wu T, Yan J Abstract The selective induction of tumor vascular thrombosis using truncated tissue factor (tTF) delivered via a target ligand is a promising novel antitumor strategy. In the present study, an anti‑neuropilin‑1 (NRP‑1) monoclonal antibody (mAb)‑streptavidin (SA):tTF‑biotin (B) composite system was established. In this system, anti‑NRP‑...
Source: International Journal of Oncology - August 12, 2019 Category: Cancer & Oncology Authors: Xu P, Zou M, Wang S, Li T, Liu C, Wang L, Wang L, Luo F, Wu T, Yan J Tags: Int J Oncol Source Type: research

TFF3 and TFF1 expression levels are elevated in colorectal cancer and promote the malignant behavior of colon cancer by activating the EMT process.
Abstract Reports on the roles of the secreted trefoil factor (TFF)1 and 3 in colorectal cancer (CRC) and their underlying mechanisms of action in tumorigenesis are not common and are controversial. In the present study, the mRNA expression and promoter methylation of TFF1 and TFF3 in cancer and adjacent normal tissues were investigated, and their association with other clinical factors and patient prognosis were evaluated. Moreover, the association between TFF3 and epithelial‑mesenchymal transition (EMT) was explored by overexpressing or inhibiting TFF3 expression. The results revealed that t...
Source: International Journal of Oncology - August 5, 2019 Category: Cancer & Oncology Authors: Yusufu A, Shayimu P, Tuerdi R, Fang C, Wang F, Wang H Tags: Int J Oncol Source Type: research

Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.
Abstract Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effect of low temperature on cell volume and cell death under hypoosmolal conditions and determine the underlying molecular mechanisms in gastric cancer (GC). Three human GC cell lines (NUGC4, KATO‑III and MKN45) were exposed to hypotonic solutions, and the effects of low temperature on cel...
Source: International Journal of Oncology - August 2, 2019 Category: Cancer & Oncology Authors: Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E Tags: Int J Oncol Source Type: research

Surgical outcomes and learning curve analysis of robotic gastrectomy for gastric cancer: Multidimensional analysis compared with three ‑dimensional high‑definition laparoscopic gastrectomy.
Surgical outcomes and learning curve analysis of robotic gastrectomy for gastric cancer: Multidimensional analysis compared with three‑dimensional high‑definition laparoscopic gastrectomy. Int J Oncol. 2019 Jul 30;: Authors: Li J, Xi H, Guo X, Gao Y, Xie T, Qiao Z, Chen L Abstract The present ambispective cohort study was performed to compare the short‑term surgical outcomes, including financial cost and surgeons' acceptance, of robotic versus three‑dimensional high‑definition (3D‑HD) laparoscopic gastrectomy for patients with gastric cancer (GC). Between 2011 and 2017, 517 ...
Source: International Journal of Oncology - July 30, 2019 Category: Cancer & Oncology Authors: Li J, Xi H, Guo X, Gao Y, Xie T, Qiao Z, Chen L Tags: Int J Oncol Source Type: research

miR ‑501‑3p promotes colorectal cancer progression via activation of Wnt/β‑catenin signaling.
In conclusion, the present study identified miR‑501‑3p as a novel regulator of Wnt/β‑catenin signaling in colorectal cancer cells via targeting APC, suggesting that miR‑501‑3p may act as a novel oncogenic miRNA in colorectal cancer. PMID: 31364752 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 30, 2019 Category: Cancer & Oncology Authors: Wu F, Xing T, Gao X, Liu F Tags: Int J Oncol Source Type: research

Long non ‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review).
Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review). Int J Oncol. 2019 Jul 29;: Authors: Jiang L, Li Z, Wang R Abstract Lung cancer is the most common malignancy with the highest mortality worldwide. Emerging research has demonstrated that long non‑coding RNAs (lncRNAs), a key genomic product, are commonly dysregulated in lung cancer and have significant functions in lung cancer initiation, progression and therapeutic response. lncRNAs may interact with DNA, RNA or proteins, as tumor suppressor genes or oncogenes, to regulate gene express...
Source: International Journal of Oncology - July 29, 2019 Category: Cancer & Oncology Authors: Jiang L, Li Z, Wang R Tags: Int J Oncol Source Type: research

RAC2 acts as a prognostic biomarker and promotes the progression of clear cell renal cell carcinoma.
Abstract As one of the most commonly reported malignancies of the urinary system, clear cell renal cell carcinoma (ccRCC) is an advanced metastatic tumor with high mortality rates. The Rac family small GTPase 2 (RAC2) is a member of the Rho GTPases. Although Rho GTPases play an important role in numerous different types of tumor, whether they have functions in ccRCC remains uncertain. The present study utilized bioinformatics analyses in order to compare the expression levels of RAC2 in ccRCC tumors vs. adjacent tissues, and assessed the association between RAC2 expression and clinicopathological paramet...
Source: International Journal of Oncology - July 26, 2019 Category: Cancer & Oncology Authors: Liu Y, Cheng G, Song Z, Xu T, Ruan H, Cao Q, Wang K, Bao L, Liu J, Zhou L, Liu D, Yang H, Chen K, Zhang X Tags: Int J Oncol Source Type: research

Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR ‑367/PTEN axis.
Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR‑367/PTEN axis. Int J Oncol. 2019 Jul 25;: Authors: Mu X, Mou KH, Ge R, Han D, Zhou Y, Wang LJ Abstract Long intergenic noncoding RNA 00961 (Linc00961) has been identified as a tumor suppressor in various types of cancer. However, the critical roles of Linc00961 in the carcinogenesis and progression of skin melanoma (SM) are yet to be fully elucidated. The present study revealed via reverse transcription‑quantitative PCR analysis that Linc00961 was downregulated in the tissues of patients with SM compared with b...
Source: International Journal of Oncology - July 25, 2019 Category: Cancer & Oncology Authors: Mu X, Mou KH, Ge R, Han D, Zhou Y, Wang LJ Tags: Int J Oncol Source Type: research

Current strategies against persistent human papillomavirus infection (Review).
Abstract Human papillomavirus (HPV) is the most common sexually transmitted infection, exhibiting a tropism for the epidermis and mucosae. The link between persistent HPV infection and malignancies involving the anogenital tract as well as the head and neck has been well‑established, and it is estimated that HPV‑related cancers involving various anatomical sites account for 4.5% of all human cancers. Current prophylactic vaccines against HPV have enabled the prevention of associated malignancies. However, the sizeable population base of current infection in whom prophylactic vaccines are not applicable, certai...
Source: International Journal of Oncology - July 23, 2019 Category: Cancer & Oncology Authors: Liu Y, Li H, Pi R, Yang Y, Zhao X, Qi X Tags: Int J Oncol Source Type: research

In vitro attenuation of classic metastatic melanoma ‑related features by highly diluted natural complexes: Molecular and functional analyses.
In vitro attenuation of classic metastatic melanoma‑related features by highly diluted natural complexes: Molecular and functional analyses. Int J Oncol. 2019 Jul 22;: Authors: Gonçalves JP, Potrich FB, Ferreira Dos Santos ML, Costa Gagosian VS, Rodrigues Rossi G, Jacomasso T, Mendes A, Bonciani Nader H, Brochado Winnischofer SM, Trindade ES, Camargo De Oliveira C Abstract Metastasis is responsible for the majority of deaths among patients with malignant melanoma. Despite recent advances, the majority of current and modern therapies are ineffective and/or financially unfeasible. Thus, in this...
Source: International Journal of Oncology - July 22, 2019 Category: Cancer & Oncology Authors: Gonçalves JP, Potrich FB, Ferreira Dos Santos ML, Costa Gagosian VS, Rodrigues Rossi G, Jacomasso T, Mendes A, Bonciani Nader H, Brochado Winnischofer SM, Trindade ES, Camargo De Oliveira C Tags: Int J Oncol Source Type: research

Interleukin ‑33 expression in ovarian cancer and its possible suppression of peritoneal carcinomatosis.
In this study, we focused on the association between the tumor expression of IL‑33 and ovarian peritoneal carcinomatosis. We used an immunosufficient murine model of peritoneal carcinomatosis and human EOC samples. The overexpression of IL‑33 in the ID8 mouse EOC cell line tumors significantly prolonged the survival of immunocompetent mice in the peritoneal carcinomatosis setting, but not in the subcutaneous model. In addition, the silencing of IL‑33 in ID8‑T6 cells (subclone with high dissemination potential) significantly shortened the survival of the tumor‑bearing mice. This was likely due to the intratumoral ...
Source: International Journal of Oncology - July 17, 2019 Category: Cancer & Oncology Authors: Sekiya A, Suzuki S, Tanaka A, Hattori S, Shimizu Y, Yoshikawa N, Koya Y, Kajiyama H, Kikkawa F Tags: Int J Oncol Source Type: research

Regulation of GKN1 expression in gastric carcinogenesis: A problem to resolve (Review).
rnández-Tilapa G Abstract Gastrokine 1 (GKN1) is a protein expressed on the surface mucosa cells of the gastric antrum and fundus, which contributes to maintaining gastric homeostasis, inhibits inflammation and is a tumor suppressor. The expression of GKN1 decreases in mucosa that are either inflamed or infected by Helicobacter pylori, and is absent in gastric cancer. The measurement of circulating GKN1 concentration, the protein itself, or the mRNA in gastric tissue may be of use for the early diagnosis of cancer. The mechanisms that modulate the deregulation or silencing of GKN1 expression have ...
Source: International Journal of Oncology - July 16, 2019 Category: Cancer & Oncology Authors: Alarcón-Millán J, Martínez-Carrillo DN, Peralta-Zaragoza O, Fernández-Tilapa G Tags: Int J Oncol Source Type: research

Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC ‑1 cells.
Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC‑1 cells. Int J Oncol. 2019 Jul 16;: Authors: Chen WT, Sun YK, Lu CH, Chao CY Abstract Hyperthermia (HT) has shown potential in cancer therapy. In particular, it appears to sensitize cancer cells to chemotherapy. However, a major concern associated with HT is that the thermal dosage applied to the tumor cells may also harm the normal tissue cells. Besides, the drugs used in HT are conventional chemotherapy drugs, which may cause serious side effects. The present study demonstrated a no...
Source: International Journal of Oncology - July 16, 2019 Category: Cancer & Oncology Authors: Chen WT, Sun YK, Lu CH, Chao CY Tags: Int J Oncol Source Type: research

A systematic review of the prevalence of DNA damage response gene mutations in prostate cancer.
Abstract Several ongoing international prostate cancer (PC) clinical trials are exploring therapies that target the DNA damage response (DDR) pathway. This systematic review summarizes the prevalence of DDR mutation carriers in the unselected (general) PC and familial PC populations. A total of 11 electronic databases, 10 conference proceedings, and grey literature sources were searched from their inception to December 2017. Studies reporting the prevalence of somatic and/or germline DDR mutations were summarized. Metastatic PC (mPC), castration‑resistant PC (CRPC) and metastatic CR...
Source: International Journal of Oncology - July 16, 2019 Category: Cancer & Oncology Authors: Lang SH, Swift SL, White H, Misso K, Kleijnen J, Quek RGW Tags: Int J Oncol Source Type: research

The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma.
Abstract Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer after hepatocellular carcinoma. Antiangiogenic therapy has been administered to patients with CCA, but the benefits of this therapy remain unsatisfactory. Improved understanding of the molecular mechanisms underlying angiogenesis in CCA is required. In the present study, the expression of GATA‑binding protein 6 (GATA6), lysyl oxidase‑like 2 (LOXL2) and vascular endothelial growth factor A (VEGFA), in addition to the microvessel density (MVD), were evaluated by performing immunohistochemical stain...
Source: International Journal of Oncology - July 15, 2019 Category: Cancer & Oncology Authors: Peng T, Deng X, Tian F, Li Z, Jiang P, Zhao X, Chen G, Chen Y, Zheng P, Li D, Wang S Tags: Int J Oncol Source Type: research

Loss of FGL1 induces epithelial ‑mesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma.
Loss of FGL1 induces epithelial‑mesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Int J Oncol. 2019 Jul 15;: Authors: Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, Du J Abstract Liver kinase b1 (LKB1) is a tumor suppressor, and the inactivated mutation frequency of LKB1 in lung adenocarcinoma is ~20%. The present study aimed to explore potential novel biomarkers in LKB1 mutant lung adenocarcinoma. Gene expression data from lung adenocarcinoma patients were downloaded from The Cancer Genome Atlas and the Gene Expression Omnibus databases. R software was used to analyze ...
Source: International Journal of Oncology - July 15, 2019 Category: Cancer & Oncology Authors: Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, Du J Tags: Int J Oncol Source Type: research

CXCL1 stimulates migration and invasion in ER ‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis.
In conclusion, the present study demonstrated that CXCL1 is highly expressed in ER‑negative BC, and stimulates BC cell migration and invasion via the ERK/MMP2/9 pathway. Therefore, CXCL1 may serve as a potential therapeutic target in ER‑negative BC. PMID: 31322183 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - July 15, 2019 Category: Cancer & Oncology Authors: Yang C, Yu H, Chen R, Tao K, Jian L, Peng M, Li X, Liu M, Liu S Tags: Int J Oncol Source Type: research

Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.
Abstract Prostate cancer is one of the most common types of cancer affecting men worldwide; however, its etiology and pathological mechanisms remain poorly understood. Mechanical stimulation plays a key role in prostate cancer development. Piezo type mechanosensitive ion channel component 1 (Piezo1), which functions as a cell sensor and transducer of mechanical stimuli, may have a crucial role in the development of prostate cancer. In the present study, the expression of the Piezo1 channel was demonstrated to be significantly elevated in prostate cancer cell lines and in human prostate malignant tumor tissues...
Source: International Journal of Oncology - July 15, 2019 Category: Cancer & Oncology Authors: Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, Jia Z Tags: Int J Oncol Source Type: research

NEAT1/miR ‑124/STAT3 feedback loop promotes breast cancer progression.
NEAT1/miR‑124/STAT3 feedback loop promotes breast cancer progression. Int J Oncol. 2019 Jul 15;: Authors: Pang Y, Wu J, Li X, Wang C, Wang M, Liu J, Yang G Abstract The long non‑coding RNA nuclear enriched abundant transcript 1 (NEAT1) has important roles in the regulation of multiple cell functions, such as proliferation, apoptosis and migration. However, the mechanism by which NEAT1 regulates breast cancer progression is not well elucidated. In the present study, NEAT1 and microRNA‑124 (miR‑124) levels were detected by reverse transcription‑quantitative PCR in breast cancer tissues an...
Source: International Journal of Oncology - July 15, 2019 Category: Cancer & Oncology Authors: Pang Y, Wu J, Li X, Wang C, Wang M, Liu J, Yang G Tags: Int J Oncol Source Type: research

Receptor tyrosine kinase, RON, promotes tumor progression by regulating EMT and the MAPK signaling pathway in human oral squamous cell carcinoma.
This study evaluated whether RON affects oncogenic behavior, oncogenic signaling pathways, and clinical outcomes, including survival, in human OSCC. Reverse transcription‑PCR, quantitative PCR, western blotting and immunohistochemical staining were used to determine mRNA and protein expression levels of RON. Cell invasion, migration and apoptosis assays were used to assess the functional effects of small interfering RNA‑mediated knockdown of RON or snail family transcriptional repressor 2 (SLUG). RON knockdown suppressed tumor cell invasion and migration and enhanced apoptosis in human OSCC cells. RON knockdo...
Source: International Journal of Oncology - July 2, 2019 Category: Cancer & Oncology Authors: Kim SA, Lee KH, Lee DH, Lee JK, Lim SC, Joo YE, Chung IJ, Noh MG, Yoon TM Tags: Int J Oncol Source Type: research

Suicide gene ‑armed measles vaccine virus for the treatment of AML.
In this study, we infected AML cell lines and primary AML cells from patients with measles vaccine virus either expressing GFP or armed with super cytosine deaminase, which converts the prodrug, 5‑fluorocytosine, into the chemotherapeutic compound, 5‑fluorouracil. Target cell density of the measles entry receptor, CD46, infection rates of targeted leukemic cells, tumor cell viability, and apoptotic rates were determined. We found that measles vaccine virus infected the leukemic blasts and profoundly diminished the number and viability of leukemic cells via the induction of apoptosis. The conversion of 5‑fluorocytosin...
Source: International Journal of Oncology - July 2, 2019 Category: Cancer & Oncology Authors: Maurer S, Salih HR, Smirnow I, Lauer UM, Berchtold S Tags: Int J Oncol Source Type: research

Prognostic index of aberrant mRNA splicing profiling acts as a predictive indicator for hepatocellular carcinoma based on TCGA SpliceSeq data.
In conclusion, the constructed computational prognostic model based on HCC‑specific alternative splicing events may be used as a molecular marker for the prognosis of HCC. PMID: 31268164 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - June 27, 2019 Category: Cancer & Oncology Authors: Wu HY, Peng ZG, He RQ, Luo B, Ma J, Hu XH, Dang YW, Chen G, Pan SL Tags: Int J Oncol Source Type: research