Double blinded, vehicle controlled, crossover study on the efficacy of a topical endocannabinoid membrane transporter inhibitor in atopic Beagles
In conclusion, the newly developed topical endocannabinoid membrane transporter inhibitor (WOL067-531) minimized allergic flares and pruritus in a canine model of AD. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 24, 2019 Category: Dermatology Source Type: research

Genetic disposition to primary hyperhidrosis: a review of literature
AbstractPrimary hyperhidrosis is a condition characterized by excessive sweating. The estimated prevalence is between 0.6 and 4.4%, and it can have economic, psychological, and social consequences for affected individuals. Family and genetic studies have suggested a genetic component in the inheritance of the disease. In this review, we summarize the current literature on genetic disposition to primary hyperhidrosis. We Identified 20 studies on Pubmed and Embase in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Probands reported a positive family history in 5.7 &...
Source: Archives of Dermatological Research - August 21, 2019 Category: Dermatology Source Type: research

Resveratrol-loaded nanoemulsion gel system to ameliorate UV-induced oxidative skin damage: from in vitro to in vivo investigation of antioxidant activity enhancement
AbstractIn the present study resveratrol nanoemulsion gel was developed and optimized with the aim of enhancing the permeability and antioxidant activity against ultraviolet (UV)-induced oxidative skin damage. Droplet size, polydispersity index, drug permeation flux, permeability coefficient and drug deposition in skin of resveratrol-loaded nanoemulsion were found to be 65.00  ± 5.00 nm, 0.171 ± 0.082, 144.50 μg/cm2/h, 2.90  × 10–2 cm/h and 45.65 ± 4.76%, respectively, whereas drug permeation flux, permeability coeffi...
Source: Archives of Dermatological Research - August 20, 2019 Category: Dermatology Source Type: research

Identification of bacterial DNA in the peripheral blood of patients with active hidradenitis suppurativa
AbstractBacterial translocation may have a role in the pathogenesis of several inflammatory conditions. A prospective analytical case –control study was designed to assess the presence of bacterial DNA in the peripheral blood of patients with hidradenitis suppurativa (HS). An age- and gender-matched control population was recruited from healthy blood donors. Demographic and HS-related data were also collected. We took fasting bl ood samples from each participant and determined the presence of bacterial DNA (including bacterial species identification) and levels TNF-α, IL-1β, and IL-17A. We included 50 pati...
Source: Archives of Dermatological Research - August 17, 2019 Category: Dermatology Source Type: research

Effect of artesunate and relation with TGF- β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear
AbstractArtesunate (ART) is the derivative of artemisinin isolated from the traditional Chinese medicineqinghao. Although several studies reported the efficiency of artesunate in the treatment of malaria, inhibiting fibroblasts and collagen synthesis, the association between artesunate and scar formation is unclear. The research was designed to study the significance of artesunate (ART) on the expression of transforming growth factor (TGF- β1) and small mother against decapentaplegic (SMAD3) in rabbit's ear hypertrophic scar model. Twenty-four New Zealand white rabbits were randomly divided into six groups: control gr...
Source: Archives of Dermatological Research - August 9, 2019 Category: Dermatology Source Type: research

Effectiveness of methotrexate in moderate to severe psoriasis patients: real-world registry data from the Swiss Dermatology Network for Targeted Therapies (SDNTT)
AbstractMethotrexate (MTX) is a frequently used anti-psoriatic drug that is commonly recommended in international psoriasis guidelines. It is effective in treating skin lesions, nail changes and psoriatic arthritis. In 2017 a prospective, multicenter, randomized, double-blind, placebo-controlled, phase 3 trial, commonly known as the METOP trial, was published assessing the effectiveness and safety of subcutaneous administration of methotrexate. Because trial data do not always relate to real-life data with unselected patient populations, we wanted to determine whether the data obtained in the METOP-trial correspond to real...
Source: Archives of Dermatological Research - August 8, 2019 Category: Dermatology Source Type: research

Substrate softness promotes terminal differentiation of human keratinocytes without altering their ability to proliferate back into a rigid environment
In conclusion, below a certain rigidity, human keratinocytes undergo genome reprogramming indicating terminal differentiation that can switch back to proliferation in contact with a stiffer environment. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 7, 2019 Category: Dermatology Source Type: research

Genetic assessment of ten Egyptian patients with Sj ögren–Larsson syndrome: expanding the clinical spectrum and reporting a novel ALDH3A2 mutation
AbstractAssessment of ten Egyptian patients with Sj ögren–Larsson syndrome (SLS) detected; unusual clinical manifestations, a first report of brain atrophy in SLS, some patients exhibited neither retinal dots nor white matter changes previously reported as essential manifestations. We identified five mutations in ALDH3A2 gene including a novel one and suggest a founder effect. Sjögren–Larsson syndrome is a rare autosomal recessive inborn error of lipid metabolism caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase and result in a triad of ichthyosis, spasticity, and men...
Source: Archives of Dermatological Research - August 6, 2019 Category: Dermatology Source Type: research

Association between sphingosine-1-phosphate-induced signal transduction via mitogen-activated protein kinase pathways and keloid formation
AbstractWe conducted this experimental study to analyze the relationship between sphingosine-1-phosphate (S1P)-induced mitogen-activated protein (MAP) kinase pathways and keloid formation. We collected samples of the normal tissue and the keloid tissue from 10 normal healthy individuals and 12 patients with keloid scars, respectively. Then, we compared the level of sphingosine-1-phosphate receptor (S1PR1/S1PR2) mRNA/protein expression between the normal tissue and the keloid tissue. Moreover, we also compared the level of S1PR protein expression, that of S1P-induced COL1A1 (collagen Type I, α-1 chain) expression, tha...
Source: Archives of Dermatological Research - August 5, 2019 Category: Dermatology Source Type: research

Filaggrin sequencing and bioinformatics tools
AbstractAtopic dermatitis (AD) is a common illness that most commonly originates in childhood, but can be seen in all ages. Filaggrin (FLG) loss of function variants have been associated with the onset and severity of atopic dermatitis and are the most common genetic association with AD. Previous studies have shown variability in the frequency of FLG variants. We have recently demonstrated that previousFLG genotyping methods were inadequate for proper genotyping. In this concise report, we show that genotyping using a popular older informatics program is problematic. In fact, publications that used the older program likely...
Source: Archives of Dermatological Research - August 1, 2019 Category: Dermatology Source Type: research

The increase of mTOR expression is consistent with FoxO1 decrease at gene level in acne but not in psoriasis
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 31, 2019 Category: Dermatology Source Type: research

Epidermal expression of eotaxins and thymic stromal lymphopoietin in eosinophil rich dermatoses
AbstractEosinophils are seen in a number of dermatologic conditions. While the extent of their function in these diseases remains to be fully elucidated, pathogenic activity in bullous pemphigoid suggests a more significant role than previously thought. Several dermatoses have a fairly characteristic histologic morphology of eosinophil infiltration. We hypothesized that epidermal expression of eotaxins and TSLP would differ by disease, perhaps explaining the different histologic morphologies. We performed a retrospective study of eosinophil rich dermatoses to perform immunohistochemistry. We collected 49 specimens composed...
Source: Archives of Dermatological Research - July 26, 2019 Category: Dermatology Source Type: research

STAT3 polymorphisms and IL - 6 polymorphism are associated with the risk of basal cell carcinoma in patients from northern Poland
AbstractBasal cell carcinoma (BCC) environment consists of stromal and inflammatory cells which produce variety of cytokines, chemokines and growth factors that may affect tumor behavior. One of the cytokines suggested to be involved in the pathogenesis of BCC is IL-6, which is the upstream element of IL-6/JAK/STAT3 pathway. The correlation between polymorphisms of the genes related to this pathway and cancer risk/prognosis have been previously investigated in several neoplasia, but available data concerning BCC are scarce. In the present study, rs1800795 (-174 G/C)IL-6 gene polymorphism and two polymorphisms in theSTAT3 g...
Source: Archives of Dermatological Research - July 24, 2019 Category: Dermatology Source Type: research

Appearance-related psychosocial distress following facial skin cancer surgery using the FACE-Q Skin Cancer
The objective of this study is to assess patient-reported appearance-related psychosocial distress following facial skin cancer surgery, and to identify independent predictors of psychosocial impairment. This was a single-center, cross-sectional study at a tertiary care cancer center including patients who underwent dermatologic surgery on the face from March 1, 2016 to March 31, 2018. Patients completed the FACE-Q Skin Cancer Appearance-related Psychosocial Distress scale postoperatively between May 21, 2018 and October 1, 2018. Patient responses were rated on a 4-point Likert scale and converted on a scale from 0 to 100....
Source: Archives of Dermatological Research - July 23, 2019 Category: Dermatology Source Type: research

Medical malpractice cases involving lack of access to dermatologists for incarcerated patients in the United States from 1982 to 2018
This study reveals limited access to dermatologists for prisoners in need of dermatologic care. Improved collaboration between prison officials, prison medical staff, and dermatologists could help improve prisoner care and limit malpractice risk. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 19, 2019 Category: Dermatology Source Type: research

Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents
In this study, we aim to investigate the effects of RH on epidermal morphogenesis and lipid barrier formation in HSEs. Therefore, two types of HSEs were developed at 90% or at 60% RH. Assessments were performed to determine epidermal morphogenesis by immunohistochemical analyses, ceramide composition by lipidomic ana lysis, and lipid organization by Fourier transform infrared spectroscopy and small-angle X-ray diffraction. We show that reduction of RH mainly affected the uppermost viable epidermal layers in the HSEs, including an enlargement of the granular cells and induction of epidermal cell activation. Neith er the com...
Source: Archives of Dermatological Research - July 18, 2019 Category: Dermatology Source Type: research

Carrier oils in dermatology
AbstractWounds are a common medical infliction. With the increase in microbial resistance and a shift of interest towards complementary medicines, essential oils have been shown to be beneficial in suppressing microbial growth. However, in practice, essential oils are more often diluted into a base due to the risk of topical adverse effects, such as dermatitis. There is a lack of collated evidence-based information on toxicity and efficacy of carrier oils. The current information on the subject matter is restricted to generic, aroma-therapeutic books and pamphlets, based on anecdotal evidence rather than an experimental ap...
Source: Archives of Dermatological Research - July 18, 2019 Category: Dermatology Source Type: research

Stem cells in aesthetic dermatology: bioethical and professional obligations
AbstractRecently, stem cells in aesthetics have attracted increased attention, especially as they have become a popular trend that is being mass-marketed to consumers on the Internet and social media. Unfortunately, studies have shown this marketing to be misleading as it portrays many purported benefits of stem cells that have yet to be proven in the limited studies that are available. It is important for clinicians to understand the evidence and marketing behind any new trends, especially in the fast-paced world of aesthetics, where treatments often outpace current medical understanding. As clinicians, we have bioethical...
Source: Archives of Dermatological Research - July 18, 2019 Category: Dermatology Source Type: research

PUVA-induced pityriasis lichenoides chronica-like papular lesions in patients with mycosis fungoides: a clinical, histopathological and immunohistochemical study
AbstractMycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma (CTCL) with many clinical variants including papular and pityriasis lichenoides chronica (PLC)-like variants. During psoralen and ultraviolet A (PUVA) treatment of MF, PLC-like papular lesions were observed to appear. The exact nature of these lesions is not fully understood. This work aimed to study PLC-like papular lesions arising in MF patients receiving PUVA therapy clinically, histopathologically and immunohistochemically (using monoclonal antibodies against CD4 and CD8) and to compare them with lesions in classic PLC patients. Fifteen...
Source: Archives of Dermatological Research - July 12, 2019 Category: Dermatology Source Type: research

Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation
This study included 21 non-obese patients with moderate psoriasis and 20 non-obese clinically healthy age and sex matched controls. Patients underwent 24 sessions of NB-UVB radiation. A 4 mm punch skin biopsy was taken from all patients before and after treatment and from the controls for estimation of tissue vaspin level by enzyme-linked immunosorbent assay. Vaspin levels was significantly lower in patients before NB-UVB (99. 72 pg/mg ± 12.11 pg/mg) compared to controls (257.34 pg/mg ± 28.11 pg/mg) with (P 
Source: Archives of Dermatological Research - July 10, 2019 Category: Dermatology Source Type: research

Analysis of patient perceptions of Mohs surgery on social media platforms
This study assessed social media content to improve understanding of patient experiences with Mohs surgery. An initial search of public Instagram posts and tweets tagged with “#mohssurgery” or “@mohssurgery” identified 1692 Instagram posts and 115 tweets, of which 1390 and 94 were eliminated, respectively, given that they did not directly include a patient’s own experience. The team analyzed the posts/tweets for patient gender, timing of post prior to or after their procedure, and classified themes related to patients’ experience with Mohs. Analysis showed that 91.4% of Instagram posts a...
Source: Archives of Dermatological Research - June 26, 2019 Category: Dermatology Source Type: research

Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial
The objectives of this study are to compare the efficacy of topical calcipotriol vs narrow band ultraviolet B phototherapy (NB-UVB) in the treatment of alopecia areata and its correlation with serum vitamin D3 levels. A randomized-controlled trial has been conducted on 60 patients with scalp alopecia areata randomized into four groups; topical calcipotriol, NB-UVB, both and placebo. All patients were evaluated by assessment of severity of alopecia areata by severity of alopecia tool (SALT) score at baseline and 3  months after treatment and vitamin D3 levels at baseline and after 3  months. SALT score and vitamin...
Source: Archives of Dermatological Research - June 24, 2019 Category: Dermatology Source Type: research

Monocytes co-cultured with reconstructed keloid and normal skin models skew towards M2 macrophage phenotype
AbstractSeveral abnormalities have been reported in the peripheral blood mononuclear cells of keloid-forming patients and particularly in the monocyte cell fraction. The goal of this in vitro study was to determine whether monocytes from keloid-prone patients contribute to the keloid phenotype in early developing keloids, and whether monocyte differentiation is affected by the keloid microenvironment. Therefore, keloid-derived keratinocytes and fibroblasts were used to reconstruct a full thickness, human, in vitro keloid scar model. The reconstructed keloid was co-cultured with monocytes from keloid-forming patients and co...
Source: Archives of Dermatological Research - June 11, 2019 Category: Dermatology Source Type: research

Ex vivo culture of keratinocytes on papillary and reticular dermal layers remodels skin explants differently: towards improved wound care
In this study, we characterised the effect that seeding keratinocytes on the papillary and reticular dermis had on the extracellular matrix and tissue integrity ex vivo. Human skin explants from consented patients (n = 6) undergoing routine surgery were cultured at a liquid–air interface, dermal-side up, and autologous keratinocytes seeded on the exposed papillary or reticular layer. After 7–21 days, histological and immunohistochemical evaluation of the morphology and extracellular matrix was performe d. While the dermis remained robust in all explants cultures, keratinocytes seeded on the p...
Source: Archives of Dermatological Research - June 5, 2019 Category: Dermatology Source Type: research

Efficacy and safety of anthralin in combination with diphenylcyclopropenone in the treatment of alopecia areata: a retrospective case series
AbstractContact immunotherapy with diphenylcyclopropenone (DPCP) and anthralin is considered the treatment option for extensive alopecia areata (AA) unresponsive to DPCP immunotherapy alone. Only one study has described the efficacy of combination therapy; therefore, we investigated whether topical DPCP and anthralin can promote hair regrowth in DPCP-non responders. In this retrospective case-series we analyzed the efficacy and side effects of DPCP with anthralin in AA patients who did not respond to several months of treatment with DPCP alone. Thirty-two DPCP-nonresponsive AA patients were treated with DPCP and anthralin ...
Source: Archives of Dermatological Research - June 5, 2019 Category: Dermatology Source Type: research

Blocking Wnt as a therapeutic target in mice model of skin cancer
In conclusion, blocking Wnt production ameliorated skin cancer via blocking pro-inflammatory cytokines and enhancing the anti-inflammatory cytokines. Moreover, blocking Wnt attenuated skin cancer-induced activation of fibrosis pathway. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - June 4, 2019 Category: Dermatology Source Type: research

Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention
AbstractAlopecia areata (AA) is an organ-specific autoimmune disease that targets the bulb of the hair follicles and results in non-scarring hair loss that can range from patchy lesions to involvement of the entire scalp. AA develops when the hair follicles lose their physiologic state of immune privilege. One of the key factors that help in maintaining this immune privilege by suppressing natural killer cells is macrophage migration inhibitory factor (MIF). Surprisingly, MIF is also known to provoke autoimmunity by upregulating cytokines. To address this dilemma and understand the exact nature of the involvement of MIF in...
Source: Archives of Dermatological Research - June 1, 2019 Category: Dermatology Source Type: research

Prurigo nodularis as a sweat gland/duct-related disorder: resolution associated with restoration of sweating disturbance
AbstractLittle attention has been given to the involvement of sweat glands/ducts in the pathogenesis of prurigo nodularis (PN). According to recent studies, PN is likely to develop under conditions characterized by dry skin, such as atopic dermatitis (AD), suggesting a strong impact of skin dryness on PN development. No therapeutic modalities produced complete resolution of PN without exacerbations. We previously reported that increases in skin dryness by sweating disturbance could initiate the development of AD. We investigated whether sweating responses were impaired in refractory PN lesions; and, if so, we asked whether...
Source: Archives of Dermatological Research - May 31, 2019 Category: Dermatology Source Type: research

Ameliorative effect of tranexamic acid on physiological skin aging and its sex difference in mice
AbstractAn effective method to protect the skin from natural aging is unknown. Therefore, in this study, we examined the ameliorative effects of tranexamic acid on natural skin aging. In addition, we examined the sex difference in the effect exhibited by tranexamic acid. We bred hairless mice without ultraviolet ray irradiation and physical stress for 2  years. During the study period, mice were orally administered tranexamic acid (12 mg/kg/day) three times per week. Development of signs of skin aging was found to be ameliorated by tranexamic acid. Furthermore, synthetic inhibition of plasmin was observed followi...
Source: Archives of Dermatological Research - May 30, 2019 Category: Dermatology Source Type: research

Treatment of acne scars with PRP and laser therapy: an up-to-date appraisal
AbstractClinically significant scarring is a common complication of acne vulgaris. Recent treatments have included the use of platelet-rich plasma (PRP), especially in combination with laser therapy. Here, we offer backgrounds on PRP and laser therapy and review combination treatment for acne scars. It is important to note that current data are limited to small studies and that there is no standard protocol for PRP administration. Larger studies are needed to better evaluate combination treatment and determine the best modality. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 29, 2019 Category: Dermatology Source Type: research

Prior exposure to dim light at night impairs dermal wound healing in female C57BL/6 mice
AbstractArtificial light at night (LAN) is a pervasive phenomenon in today ’s society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effects of dim LAN (DLAN) on wound healing. Female C57BL/6 mice were housed for 3 weeks in DLAN or LD conditions prior to wounding. Following wounding, mice were maintained in either their previous light conditions or switched to the opposite lighting conditions for 3 weeks. DLAN prior to wo...
Source: Archives of Dermatological Research - May 29, 2019 Category: Dermatology Source Type: research

Alterations in IL-4, IL-10 and IFN- γ levels synergistically decrease lipid content and protein expression of FAS and mature SREBP-1 in human sebocytes
In this study, human sebocytes were treated wi th 0.1–10.0× of IL-4, IL-10, IL-12 and IFN-γ for 3 or 5 days to elucidate the effects on lipid content. Treatment with individual cytokines decreased the lipid content at specific concentrations rather than in a concentration-dependent manner. Specifically, 5.0× of IL-4, 5.0× of IFN-γ (5.0IF N), and 0.5×, 5.0× and 10.0× of IL-10 for 3 days, and 0.5× of IL-4 (0.5IL4) for 5 days decreased lipid content to 87.6–93.0% of the control. Treatment with other concentrations of IL-4, IL-10 and IFN-γ, ...
Source: Archives of Dermatological Research - May 24, 2019 Category: Dermatology Source Type: research

Alterations in the inflammatory cells infiltrating basal cell carcinomas during immunocryosurgery
AbstractImmunocryosurgery, the combination modality of a cryosurgery session at day 14 of a 5-week daily imiquimod treatment cycle, has shown remarkable efficacy in the treatment of basal cell carcinoma (BCC). The modality was designed to exploit synergy of antitumor effects, including the induction of immune responses, elicited by imiquimod and cryosurgery. Herein, we report on the infiltration of the BCC by selected inflammatory cell species during an immunocryosurgery treatment cycle. The density of tissue infiltrating CD68+, CD3+ and Foxp3+ cells was studied by immunohistochemistry in 56 BCC biopsies from 28 treated si...
Source: Archives of Dermatological Research - May 21, 2019 Category: Dermatology Source Type: research

Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders
AbstractThe grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “res...
Source: Archives of Dermatological Research - May 21, 2019 Category: Dermatology Source Type: research

Staphylococcus aureus colonization and chronic hand eczema: a multicenter clinical trial
AbstractChronic hand eczema is a common chronic inflammatory skin disease that influences public health.Staphylococcus aureus colonization plays important roles in chronic hand eczema morbidity and progression, which also correlated to chronicity and severity of the disease. In this multicenter clinical trial, we aim to investigate the relationship betweenS. aureus colonization and chronic hand eczema. Eighty patient volunteers diagnosed with chronic hand eczema in 4 hospitals from 4 cities participated in this study.Staphylococcus aureus colonization was determined using Polymerase Chain Reaction and fluorescent labeling ...
Source: Archives of Dermatological Research - May 14, 2019 Category: Dermatology Source Type: research

Narrowband UVB treatment induces expression of WNT7B, WNT10B and TCF7L2 in psoriasis skin
This study shows for the first time significant UVB induced upregulation of WNT7B, WNT10B and TCF7L2 in patients with psoriasis and suggests a potential role of these genes in psoriasis pathogenesis. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 14, 2019 Category: Dermatology Source Type: research

Patients with alopecia areata show signs of insulin resistance
AbstractAlopecia areata (AA) is an autoimmune disease associated with high levels of proinflammatory cytokines. Since chronic inflammation plays a major role in the pathogenesis of insulin resistance, AA can theoretically increase the risk of diabetes. We sought to investigate this theory by conducting a case –control study. Sixty patients with alopecia areata and 60 healthy volunteers (matched for age, sex, and body mass index) were evaluated. Fasting blood glucose (FBS), C-peptide, plasma insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured for each individual. Pla sma levels of ...
Source: Archives of Dermatological Research - May 14, 2019 Category: Dermatology Source Type: research

Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus
This study was undertaken to assess whether similar expression exists in lichen planus pigmentosus (LPP). We recruited 30 patients of treatment-naïve ‘LPP’ (in absence of cutaneous/mucosal LP elsewhere, group 1), 10 patients having active treatment-naïve cutaneous ‘LP’ (group 2), 10 patients having ‘post-LP’ hyperpigmentation (in absence of active LP and off treatment for at least past 3 months, group 3), and 10 controls. Quantitative real-time polymerase chain reaction (qRT-PCR, peripheral blood mononuclear cells [PBMCs] a nd skin) and immunohistochemistry (IHC, skin) was...
Source: Archives of Dermatological Research - May 14, 2019 Category: Dermatology Source Type: research

Carboxyethyl aminobutyric acid (CEGABA) lacks cytotoxicity and genotoxicity and stimulates cell proliferation and migration in vitro
This study assessed the in vitro efficacy and safety of CEGABA. NHI-3T3 mouse fibroblast cell line was treated with two CEGABA concentrations (50 and 500  μmol/L) for 24 h, 48 h, and 72 h. Cytotoxicity and genotoxicity were evaluated by colorimetry (MTT) and the alkaline version of the comet assay, respectively. Flow cytometry and the scratch-wound assay were used to assess cell-cycle phase distributions and cell migration rates. Compared with t he untreated control, CEGABA increased cell growth 1.6 times after 72 h, independent of dose. The compound also decreased cell replication time by 4&nbs...
Source: Archives of Dermatological Research - May 13, 2019 Category: Dermatology Source Type: research

A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts
AbstractThe exposure of naked unprotected skin to solar radiation may result in numerous acute and chronic undesirable effects. Evidence suggests that silymarin, a standardized extract fromSilybum marianum (L.) Gaertn. seeds, and its major component silybin suppress UVB-induced skin damage. Here, we aimed to investigate the UVA-protective effects of silymarin ʼs less abundant flavonolignans, specifically isosilybin (ISB), silychristin (SC), silydianin (SD), and 2,3-dehydrosilybin (DHSB). Normal human dermal fibroblasts (NHDF) pre-treated for 1 h with flavonolignans were then exposed to UVA light using a solar simulat...
Source: Archives of Dermatological Research - May 11, 2019 Category: Dermatology Source Type: research

Retronychia of the toenails: a review with emphasis on pathogenesis, new diagnostic and management trends
AbstractRetronychia is a condition, first described in 1999, characterized by the embedding of the proximal nail plate into the proximal nail fold and the stacking of a multiple generations of nail plates beneath the proximal nail fold. The disease affects frequently the toenails and is associated with stress-relevant situations including repetitive trauma, ischemic etiologies, postpartum, and compartment syndrome. Predisposing factors including static disorder of the feet may be underestimated. The paucity of data regarding the predisposing factors is because existing studies are limited to small case reports, case series...
Source: Archives of Dermatological Research - May 10, 2019 Category: Dermatology Source Type: research

Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids
AbstractKeloid resection followed by adjuvant radiotherapy is the most efficacious treatment for keloids. However, for earlobe keloids, an optimal protocol for the total dose and fractions of adjuvant radiation has not yet been established. We retrospectively analyzed the efficacy and safety of immediate three-fraction electron radiotherapy after operation for resistant earlobe keloids. From 2011 to 2017, three-fraction electron radiotherapy with single dose of 5  Gy was given postoperatively to 23 patients with 30 keloids in our hospital. The first fraction of adjuvant radiotherapy was administered within 2 h of...
Source: Archives of Dermatological Research - April 30, 2019 Category: Dermatology Source Type: research

Seasonal variation in the internet searches for psoriasis
AbstractSome researches with different designs investigated the seasonal pattern of psoriasis; however, the seasonal variation in public interest in psoriasis has not yet been examined. The monitoring of internet search activity has increasingly been used to gain insights into public interest in health-related topics. The aim of the investigation is to employ the Google Trends datasets to evaluate whether a seasonal trend exists in the internet searches of psoriasis by the general public. In the observational investigation, the Google Trends was queried for the [psoriasis] in the United States, the United Kingdom, Canada, ...
Source: Archives of Dermatological Research - April 25, 2019 Category: Dermatology Source Type: research

Comparison of physical and mental functioning among moderate-to-severe psoriasis patients on biologic versus oral therapy
AbstractWith the extensive variety of available treatments for psoriasis, it is paramount that clinicians understand the differences between therapies. A critical literature gap exists regarding the effects of different systemic therapies on physical and mental functioning in the US psoriasis population. We sought to compare the impact of biologic versus oral therapy on measures of physical and mental functioning among US adults with moderate-to-severe psoriasis. We performed a nationwide, cross-sectional study of 2,431,282 (weighted) (183 non-weighted) US adults with psoriasis on biologic or oral therapy using the 2003 &n...
Source: Archives of Dermatological Research - April 24, 2019 Category: Dermatology Source Type: research

The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population
AbstractAlcohol intake affects in great the symptoms and life of   psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based c ase–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs atADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1,...
Source: Archives of Dermatological Research - April 22, 2019 Category: Dermatology Source Type: research

Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing
AbstractThis work aimed to evaluate the in vivo capacity of a vegetable oil blend formulation (VOB) developed to accelerate cutaneous wound closure. Total thickness wounds were punctured on the skin on the back side of each animal and topically treated with the VOB formulation, Dersani® ointment or the vehicle control. After 2, 7, 14, 21  days post-wounding, five animals from each group were euthanized, and the rates of wound closure and re-epithelialization were evaluated. The wounds were harvested for histological and biochemical analysis. VOB resulted in faster and greater re-epithelialization in the in vivo ex...
Source: Archives of Dermatological Research - April 22, 2019 Category: Dermatology Source Type: research

Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways
This study highlights a great potent ial of the use of bLF in developing drugs to treat hair loss. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 20, 2019 Category: Dermatology Source Type: research

NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3 β/β-catenin pathway
This study suggested that NAV2 could induce melanoma proliferation and invasion by epithelial–mesenchymal transition through the GSK-3β/β-catenin-SNAI2 pathway. Our findings on the pathologi cal mechanisms of NAV2-associated cutaneous melanoma may contribute to the development of potential therapeutic strategy for melanoma. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 17, 2019 Category: Dermatology Source Type: research

Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis
AbstractFatty acid-binding proteins play an inconclusive role in lipid metabolism and cardiometabolic diseases (CMDs) which are closely related with psoriasis. Aim of the study was to investigate the diagnostic value of serum liver fatty acid-binding protein (FABP1) level and associations with disease severity, inflammation or metabolic parameters and influence of systemic treatment in psoriatic patients. The study included thirty-three patients with active plaque-type psoriasis and eleven healthy volunteers. Blood samples were obtained before and after 12  weeks of therapy with methotrexate and acitretin. Serum FABP1...
Source: Archives of Dermatological Research - April 16, 2019 Category: Dermatology Source Type: research

Association of dermatomyositis with systemic and opportunistic infections in the United States
In conclusion, dermatomyositis is associated with higher odds, costs and inpatient mortality from serious and opportunistic infections. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 6, 2019 Category: Dermatology Source Type: research