Attitudes and perceived barriers toward store-and-forward teledermatology among primary care providers of the rural Mississippi
AbstractTelehealth expands the capacity to care for patients in rural and underserved settings. Store-and-forward teledermatology is a simple and effective approach which enables remote dermatological diagnosis and treatment. Implementing store-and-forward technology in rural Mississippi has the potential to expand access to dermatology services at locations, where an in-person dermatologist is not available including: emergency rooms, urgent care centers, and primary care practices. A survey study was conducted to assess perceived obstacles and attitudes about store-and-forward teledermatology among primary care providers...
Source: Archives of Dermatological Research - February 25, 2021 Category: Dermatology Source Type: research

Actinic cheilitis or discoid lupus erythematosus?
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 24, 2021 Category: Dermatology Source Type: research

Actinic cheilitis may resemble oral lichenoid-type lesions or discoid lupus erythematosus
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 24, 2021 Category: Dermatology Source Type: research

Complex skin cancer treatment requiring reconstructive plastic surgery: an interview study on the experiences and needs of patients
The objective was to explore the experiences and needs of patients who had undergone surgical treatment by a dermatologist for a complex skin cancer with a subsequent reconstruction by a plastic surgeon. An interview study was conducted among 16 patients who had undergone surgical treatment by a dermatologist and reconstruction by a plastic surgeon for basal cell carcinoma, cutaneous squamous cell carcinoma, or lentigo maligna. The interviews focused on patients ’ experiences and needs regarding care using a predefined topic list. All interviews were audio-taped, transcribed verbatim and inductively analyzed using At...
Source: Archives of Dermatological Research - February 21, 2021 Category: Dermatology Source Type: research

Review and reappraisal of assessment parameters of second intention healing after Mohs micrographic surgery
AbstractMohs micrographic surgery (MMS) is used to remove cutaneous tumors in cosmetically sensitive anatomic areas. Surgeons can provide several reconstructive options to patients following tumor removal, including primary closure, skin grafts, local, regional or free flaps, and secondary intention healing (SIH). Notably, with the advancement of surgical and reconstructive techniques, the use of second intention healing has declined and may be underutilized. This review aims to critically evaluate the literature regarding indications, anatomical considerations, advantages, and complications of second intention wound heali...
Source: Archives of Dermatological Research - February 20, 2021 Category: Dermatology Source Type: research

Risankizumab in real life: preliminary results of efficacy and safety in psoriasis during a 16-week period
AbstractNo data on real-life experiences of risankizumab efficacy and safety are reported, apart from two isolated case reports. We carried out a single-centre, prospective study to assess the efficacy and safety of risankizumab. Fourteen patients were included (mean age 44.5  ± 14.2 years). Mean PASI decreased from 12.3 ± 5.2 (baseline) to 4.4 ± 2.7 at week 4 (p 
Source: Archives of Dermatological Research - February 20, 2021 Category: Dermatology Source Type: research

Odds of Merkel cell carcinoma metastases associated with primary anatomic site and laterality
This study aims to examine associations between primary tumor anatomic site, laterality, and metastases in MCC in the Surveillance Epidemiology and End Results (SEER) database and an academic center MCC database in Rhode Island (RI). A retrospective chart review of 92 MCC cases from RI Hospital and 2845 subjects from the SEER registry was analyzed. Logistic regressions in each cohort were performed to calculate odds ratios (OR), adjusting for sex, age at diagnosis, race, and marital status. The majority of tumors were left-sided in the SEER cohort (53.0%) and RI cohort (56.5%), and located on the head and neck region in th...
Source: Archives of Dermatological Research - February 18, 2021 Category: Dermatology Source Type: research

“ COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment”
In this report of 4 cases with distinct clinical histories and presentations: one case occured following a community acquired COVID-19 infection, one case occured in a study subject in the mRNA-1273 clinical phase III trial, one case occurred following the first dose of publically available mRNA-1273 vaccine (Moderna, Cambridge MA), and the last case occurred after the second dose of BNT162b2 vaccine (Pfizer, New York, NY). Injectable HA dermal fillers are prevalent in aesthetic medicine for facial rejuvenation. Structural modifications in the crosslinking of HA fillers have enhanced the products ’ resistance to enzy...
Source: Archives of Dermatological Research - February 9, 2021 Category: Dermatology Source Type: research

Plateletcrit values may not be higher in patients with vitiligo
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 9, 2021 Category: Dermatology Source Type: research

Dermatopathology practice in the era of COVID-19
This article aims at reviewing the challenges and effects of COVID-19 on the practice of dermatopathology in view of the current guidelines. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 9, 2021 Category: Dermatology Source Type: research

The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial
AbstractPlatelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54  years ± 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as c...
Source: Archives of Dermatological Research - February 7, 2021 Category: Dermatology Source Type: research

Validity and reliability of a novel numeric rating scale to measure skin-pain in adults with atopic dermatitis
AbstractLittle is known about the measurement properties of numeric rating scales (NRS) for pain in AD. We evaluated a novel NRS for skin-pain and existing NRS for average overall-pain in adults with AD. Self-administered questionnaires and skin-examination were performed in 463 AD patients (age 18 –97 years) in a dermatology practice setting. Numeric rating scales skin-pain and average overall-pain had moderate correlations with each other, and multiple clinician-reported and patient-reported AD severity outcomes (Spearman correlations,P 
Source: Archives of Dermatological Research - February 6, 2021 Category: Dermatology Source Type: research

To see or not to see: Impact of viewing facial skin cancer defects prior to reconstruction
AbstractPatient expectations of the scar after Mohs micrographic surgery (MMS) are often not realistic, leading to subsequent psychosocial sequelae such as anxiety, depression, and avoidance of social situations. When patient expectations are not met, this may also contribute to a decrease in patient satisfaction after surgery. Therefore, altering expectation levels may change patient satisfaction and psychosocial distress levels after surgery. To assess whether patient satisfaction improves in patients after MMS when patients view the surgical defect prior to reconstruction. Patients undergoing facial MMS between December...
Source: Archives of Dermatological Research - January 30, 2021 Category: Dermatology Source Type: research

The inpatient burden of pyoderma gangrenosum and associated comorbidities in children in the United States
AbstractPyoderma gangrenosum is an ulcerating inflammatory condition defined pathologically by an abundance of neutrophils in the absence of infection. Often, hospital admission is necessary for rapidly progressing PG for wound care and adequate pain control. However, few large-scaled controlled studies exist examining hospitalizations for PG in the pediatric populations and the associated comorbidities. We sought to determine the prevalence, length of stay (LOS), cost of care, and any risk factors for admission and associated comorbidities in children hospitalized for PG in the U.S. Data were analyzed from the 2002 to 201...
Source: Archives of Dermatological Research - January 28, 2021 Category: Dermatology Source Type: research

Temporal trends of birthweight are not driving trends of atopic dermatitis prevalence in United States children
In conclusion, there is a slight association between greater birthweights and AD prevalence. However, temporal trends of birthweight do not account for trends of childhood AD prevalence in the United States. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 25, 2021 Category: Dermatology Source Type: research

Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions
AbstractOrgan culture of microdissected scalp hair follicles (HFs) has become the gold standard for human ex vivo hair research; however, availability is becoming very limited. Although various simplistic “HF-equivalent” in vitro models have been developed to overcome this limitation, they often fail to sufficiently mimic the complex cell–cell and cell–matrix interactions between epithelial and mesenchymal cell populations that underlie the specific growth processes occurring in a native HF. Here, we have attempted to overcome these limitations by developing a novel human hair research model that co...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis
AbstractIntradermal injection of autologous platelet-rich plasma (PRP) is a non-surgical cosmetic therapy to rejuvenate the periorbital area pathologies of wrinkles, periorbital hyperpigmentation (POH), and photoaging. The past decade has seen the adoption of this novel therapy around the world. This is the first systematic review and meta-analysis evaluating PRP treatment of periorbital pathologies. This is a PRISMA compliant review that includes a comprehensive search of the databases Cochrane Library, Ovid Medline, Ovid Embase, and clinicaltrials.gov. The search was performed in June 2019 to obtain all peer-reviewed art...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Cryotherapy plus low-dose oral isotretinoin vs cryotherapy only for the treatment of anogenital warts: a randomized clinical trial
ConclusionCombined therapy showed a slight not significant efficacy for anogenital warts in Hispanic patients. Low-dose isotretinoin seems to be safe even when it is used with cryotherapy on anogenital warts.Trial registrationOn April 25, 2019 with registration number DE19-00004, CONBIO ÉTICA-19-CEI-001–20160404. Prospectively registered. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Facilitators of and obstacles to consultation in patients with advanced basal cell carcinoma: a French pilot study
The objective of this study was to identify the psychosocial factors involved in delayed consultation. We used a qualitative approach, conducting semi-structured interviews with advanced basal cell carcinoma patients and the healthcare staff of a dermatology unit to explore why some patients consult only when basal cell carcinoma is advanced. We then put our findings into perspective and created a logical model for change. We interviewed 14 patients and 12 healthcare staff. The first lesion was associated with banalization. Then, denial and fear of diagnosis or treatment were post common. Finally, the advanced basal cell c...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

A fast and effective solution for ingrown toenail: Creation of a 2-mm space between tissue and nail by sutureless lateral longitudinal excision
AbstractNails have both functional and aesthetic importance. Undertreatments cause frequent recurrences affecting its functionality, while over-treatment spoils the aesthetic view. To describe the most practical and aesthetic method to treat ingrown toenail. All patients with ingrown toenail who applied to outpatient clinics of General Surgery Department between 2013 and 2019 were enrolled. A 2-mm space between tissue and nail by lateral longitudinal excision was created with only minimal matricectomy, under local anaesthesia. A total of 2334 surgical procedures were performed in 2118 patients. Recurrence rate was 1.7% dur...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Epoprostenol up-regulates serum adiponectin level in patients with systemic sclerosis: therapeutic implications
ConclusionEpoprostenol infusions up-regulate the serum concentration of adiponectin in patients with systemic sclerosis. In our opinion, future studies on treatments in systemic sclerosis should address the issue of their effect on adipokine metabolism. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231
AbstractGrowing evidence has revealed that circular RNAs (circRNA) play critical roles in cancer progression. Here, we examined the function of a novel circRNA, Circ_0005795, in basal cell carcinoma (BCC) and explored the possible molecular mechanism. Nodular BCC and adjacent non-tumor tissues derived from 30 patients and 2 BCC cell lines were applied to analyze gene expression. Circ_0005795 loss- and gain-of-function were constructed to investigate BCC progression. Nuclear and cytoplasmic fractionation and luciferase assay were carried out to determine cellular localization and molecular interaction of Circ_0005795. Circ_...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Dysregulated microRNA expression in IL-4 transgenic mice, an animal model of atopic dermatitis
In this study, we aim to study differential expression of microRNAs in IL-4 Tg mice. As compared with wild-type mice, we found that 10 and  79 microRNAs are dysregulated in the skin of IL-4 mice before and after the onset of skin lesions, respectively. Bioinformatic analysis and previous reports show that these dysregulated microRNAs may be involved in the NF-κB, TLRs, IL-4/IL-13, MAPK and other pathways. We also found that miR-139-5 p and miR-196b-3p are significantly up-regulated in the peripheral blood of IL-4 Tg mice. Taken together, our data have identified many dysregulated microRNAs in IL-4 Tg mice, which...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

A call to action: why medical education curriculum needs to encourage young physicians to innovate
AbstractPatient-centered and physician-led innovations are key to promoting physicians as visionary leaders in the healthcare system especially during times of crises. COVID-19 has inspired some promising recent advancements within medicine worth noting, including improvements in telemedicine, 3-D printed personal protective equipment (PPE) and ventilators, drug and vaccine development, sterilization of PPE allowing for reuse, and point of care testing; they highlight a broader lesson for how we might innovate better within medicine, even after the crisis has passed. As such, with the complexities of modern-day medicine, t...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Surgical training tools for dermatology trainees: porcine vs. synthetic skin for excision and repair
The objectives  of this study are to assess trainee preference for silicone-based synthetic skin compared with porcine skin as a surgical training medium and to assess the ability of trainees to successfully demonstrate basic surgical skills using the simulated skin model. Participants were a convenience sample o f dermatology residents from the greater Chicago area, who were asked to perform an elliptical excision and bilayered repair on a silicone-based synthetic skin model. Residents were then surveyed regarding their satisfaction with the model. Four blinded dermatologist raters evaluated digital photogr aphs obta...
Source: Archives of Dermatological Research - January 12, 2021 Category: Dermatology Source Type: research

Follow-up of skin lesions during COVID-19: a description of a DRESS case
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 6, 2021 Category: Dermatology Source Type: research

Evaluation of patient attitudes towards the technical experience of synchronous teledermatology in the era of COVID-19
AbstractTeledermatology has become critical for maintaining patient access to dermatologic services since the eruption of the COVID-19 pandemic. This survey of first-time synchronous teledermatology patients (n = 100) seen by providers of the University of Mississippi Medical Center during Spring 2020 was designed to learn more about patient experiences associated with the technical challenges of synchronous teledermatology. Our patient population had considerable experience with various social media including Facebook (82%) and hardware platforms, such as Apple devices (66%). We found that the majority of pa...
Source: Archives of Dermatological Research - January 5, 2021 Category: Dermatology Source Type: research

Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease
In conclusion, modulation of pro- and anti-inflammatory DCs in active vitiligo patients may affect cytokines production and thereby, lead to further depigmentation of skin. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 5, 2021 Category: Dermatology Source Type: research

The PD-1/PD-L1 pathway in murine hair cycle transition: a potential anagen phase regulator
In conclusion, our findings indicated that PD-1/PD-L1 signaling may act as a negative regulator of hair cycle transition. Anti-PD-1/PD-L1 therapy may thus be a promising strategy for treating anagen-reduced hair loss. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 5, 2021 Category: Dermatology Source Type: research

Challenges of securing insurance approval for oral tofacitinib for the treatment of alopecia areata: a multi-institution retrospective review
AbstractAlopecia areata (AA) is a psychologically distressing disorder for which few reliable treatments exist. Although oral tofacitinib has demonstrated efficacy in treating AA, it is not approved by the Food and Drug Administration (FDA) for this indication. To investigate and identify the challenges associated with securing insurance approval for oral tofacitinib for AA. We conducted a retrospective review of patient records from two academic medical centers to identify patients with AA in whom insurance approval was sought for oral tofacitinib from 2015 –2019. We recorded information on prior authorization (PA) ...
Source: Archives of Dermatological Research - January 5, 2021 Category: Dermatology Source Type: research

What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review
AbstractThe impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was  to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed by running combinations of search terms in MEDLINE and EMBASE. Overall, 250 SR met inclusion criteria, of wh ich 225 specified search strategies. SR using 5–6 terms (20.0% to 12.1%) or ≥ 7 (40.0% to 18.8%) terms decreased, whereas SR using 3–4 terms numerically increas...
Source: Archives of Dermatological Research - November 22, 2020 Category: Dermatology Source Type: research

Development of international clinical practice guidelines: benefits, limitations, and alternative forms of international collaboration
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 20, 2020 Category: Dermatology Source Type: research

Principles for developing and adapting clinical practice guidelines and guidance for pandemics, wars, shortages, and other crises and emergencies: the PAGE criteria
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 18, 2020 Category: Dermatology Source Type: research

Core outcome sets and core outcome measures: a primer
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 18, 2020 Category: Dermatology Source Type: research

Does daily bathing or showering worsen atopic dermatitis severity? A systematic review and meta-analysis
AbstractThe optimal frequency of water bathing/showering in atopic dermatitis (AD) is unknown. We sought to determine the efficacy of different bathing/showering frequencies at improving AD severity. A systematic review and meta-analysis was performed of studies evaluating the clinical efficacy of bathing/showering regimen in AD. MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan electronic periodical services and CiNii were searched. Two authors independently performed title/abstract and full-text review and data extraction. All 13 included studies were prospective and demonstrated ...
Source: Archives of Dermatological Research - November 16, 2020 Category: Dermatology Source Type: research

Sun exposure reduction by melanoma survivors with wearable sensor providing real-time UV exposure and daily text messages with structured goal setting
AbstractDespite knowledge of subsequent melanoma risk and the benefit of sun protection in risk reduction, melanoma survivors often do not engage in adequate sun protection and continue to sunburn at rates similar to individuals without a history of skin cancer. This novel intensive intervention provided a wearable UV sensor delivering real-time UV exposure with a smartphone and daily text messages. On days 1 –10 (period 1), behavioral facilitation and outcome expectancies messages were provided. On day 10, participants reviewed and reflected on their daily UV exposure on the previous 10 days and set goals for i...
Source: Archives of Dermatological Research - November 13, 2020 Category: Dermatology Source Type: research

Broad versus narrow clinical practice guidelines: avoiding rules for the high risk 1%
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 11, 2020 Category: Dermatology Source Type: research

Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations
AbstractThe human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patients. The broad infective capacity of SARS-CoV-2 is related to the pattern of expression of the viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2 infection due to their high expression of ACE2 and TMPRSS2, which explains the clinical ...
Source: Archives of Dermatological Research - November 6, 2020 Category: Dermatology Source Type: research

Comparative utility of appropriate use criteria versus clinical practice guidelines
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 6, 2020 Category: Dermatology Source Type: research

Hair dyes: a systematic review of pertinent in vivo human studies
This article provides a critical overview to update work published in the area of in vivo hair dye penetration in humans. Studies are in humans, with one including rhesus monkey and one including in vitro human skin. MEDLINE, PubMed, Embase, Scopus, Web of Science, and Google Scholar databases were searched from 2004 to October 2019 for articles with experimental methodology on in vivo percutaneous absorption of hair dyes in humans and six studies were included. Findings indicate that percutaneous penetration occurs with hair dye use, with less absorbed in hairdressers. However, much remains unknown about the penetration o...
Source: Archives of Dermatological Research - November 5, 2020 Category: Dermatology Source Type: research

Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions
AbstractWhile isotretinoin has been the gold-standard of therapy for severe acne since its approval in 1982, its anti-inflammatory properties makes it a potentially applicable and versatile therapy for a wide variety of dermatologic conditions yet to be explored. This systematic review comprehensively recounts the success of oral isotretinoin in non-acne cutaneous diseases and provide insight into future directions of isotretinoin utility. A systematic literature review was performed using PubMed. Search terms included “isotretinoin” OR “accutane” AND “skin” OR “dermatology” ...
Source: Archives of Dermatological Research - November 5, 2020 Category: Dermatology Source Type: research

Multisociety and multispecialty clinical practice guidelines
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - November 5, 2020 Category: Dermatology Source Type: research

Office practices that may improve the experience of the cosmetic dermatology patient
AbstractPatients presenting for cosmetic dermatology procedures are often interested in lifestyle enhancement rather than treatment of an inflammatory or neoplastic disease or condition. In addition to good clinical outcomes, they may also particularly value the quality of the patient experience in the dermatology office. A list of beneficial practices that may improve patient experience was generated by interviewing staff members from several US practices, including clinic administrators, nurses, nurse managers, medical assistants, physician assistants, patient care coordinators, and dermatologists. Each was asked ten ope...
Source: Archives of Dermatological Research - November 1, 2020 Category: Dermatology Source Type: research

Risk of adverse events due to high volumes of local anesthesia during Mohs micrographic surgery
This study aimed to determine the safety and adverse effects seen in patients that receive larger amounts of locally injected lidocaine. A retrospective chart review of 563 patients from 1992 to 2016 who received over 30  mL of locally injected lidocaine was conducted. Patient records were reviewed within seven postoperative days for complications. The average amount of anesthesia received was 40 mL, and the average patient weight was 86.69 kg. 1.4% of patients had a complication on the day of surgery, and 4.4% o f patients had a complication within 7 days of the surgery. The most common complications were e...
Source: Archives of Dermatological Research - October 30, 2020 Category: Dermatology Source Type: research

Upstaging of basal cell and squamous cell carcinomas during definitive surgery: a review of predictive preoperative clinical and histologic features
AbstractThe incidence of nonmelanoma skin cancer (NMSC) in the United States is increasing with approximately 3.6 million cases diagnosed per year. The staging and treatment of NMSC is guided by histologic subtype based on skin biopsy, along with other tumor-specific factors. However, a biopsy only represents a portion of the tumor, so there is a risk of upstaging at the time of definitive surgery. We conducted a review of the literature and found that a significant proportion of NMSC were upstaged during surgery. The rate of upstaging of basal cell carcinoma (BCC) was 7 –31% and that of squamous cell carcinoma in si...
Source: Archives of Dermatological Research - October 27, 2020 Category: Dermatology Source Type: research

The impact of prurigo nodularis on quality of life: a systematic review and meta-analysis
In conclusion, QoL is negatively impacted in PN. Future studies are neces sary to determine the best instruments of measuring QoL in PN patients, better understand this association, and assess the impact in males and females separately. PROSPERO CRD42019136193. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - October 27, 2020 Category: Dermatology Source Type: research

The effect of antibiotic prophylaxis on infection rates in mohs micrographic surgery: a single-institution retrospective study
AbstractAs data and recommendations regarding antibiotic prophylaxis in dermatologic surgery vary, we tried to describe the effect of antibiotic prophylaxis (AP) in Mohs micrographic surgery (MMS) on infective endocarditis, prosthetic joint infection, and surgical site infection using a single-institution retrospective cohort study of antibiotic use (pre-/intra-operative, post-operative or none) among 2,364 patient encouters treated with MMS. Bivariate logistic regression was evaluated for associations between patient and operative characteristics, antibiotic use, and infectious complications. 85.8% of patients received no...
Source: Archives of Dermatological Research - October 24, 2020 Category: Dermatology Source Type: research

Association of surgical interval and survival among hospital and non-hospital based patients with melanoma in North Carolina
This study was aimed at quantifying the association between the timeliness of surgical excision and overall survival in patients diagnosed with melanoma in hospital- and non-hospital-based settings, using a retrospective cohort study of patients with stage 0 –III melanoma and using data linked between the North Carolina Central Cancer Registry to Medicare, Medicaid, and private health insurance plan claims across the state. We identified 6,496 patients diagnosed between 2004 and 2012 with follow-up through 2017. We categorized the time from diagnostic biopsy to surgical excision as   90 days after ...
Source: Archives of Dermatological Research - October 23, 2020 Category: Dermatology Source Type: research

Treatment strategies for hidradenitis suppurativa: real-life data from a tertiary Greek hospital
AbstractHidradenitis suppurativa (HS) is a difficult-to-treat chronic relapsing skin disease, which greatly impacts the quality of life. To bring forward real-life challenges in the decision-making process regarding HS treatment. A retrospective observational study was performed with treatment-related data derived from the HS archive of tertiary hospital-based First Department of Dermatology and Venereology of Aristotle University, Greece. Data were available for 121 patients, 63 men (52.7%) and 58 women (47.93%) with a mean age of 38  years. Doxycycline 100 mg twice daily for 1–2 weeks and then once d...
Source: Archives of Dermatological Research - October 22, 2020 Category: Dermatology Source Type: research

Sub-classification of Hidradenitis suppurativa: a cross-sectional study
AbstractThe typical Hidradenitis Suppurativa (HS) patient is a young woman with axillary and groin involvement, but the spectrum of the disease presentation is broad and no internationally acknowledged sub-classification of the disease exists to date. It is however speculated that different, yet unidentified, subtypes may respond differently to different treatments or carry a different prognosis. Classification according to self-reported clinically meaningful outcomes for patients offer practical advantages. Our objective was to build an empirical framework for sub-classification of HS patients based on the frequency of HS...
Source: Archives of Dermatological Research - October 21, 2020 Category: Dermatology Source Type: research