The effect of antibiotic prophylaxis on infection rates in mohs micrographic surgery: a single-institution retrospective study
AbstractAs data and recommendations regarding antibiotic prophylaxis in dermatologic surgery vary, we tried to describe the effect of antibiotic prophylaxis (AP) in Mohs micrographic surgery (MMS) on infective endocarditis, prosthetic joint infection, and surgical site infection using a single-institution retrospective cohort study of antibiotic use (pre-/intra-operative, post-operative or none) among 2,364 patient encouters treated with MMS. Bivariate logistic regression was evaluated for associations between patient and operative characteristics, antibiotic use, and infectious complications. 85.8% of patients received no...
Source: Archives of Dermatological Research - October 24, 2020 Category: Dermatology Source Type: research

Association of surgical interval and survival among hospital and non-hospital based patients with melanoma in North Carolina
This study was aimed at quantifying the association between the timeliness of surgical excision and overall survival in patients diagnosed with melanoma in hospital- and non-hospital-based settings, using a retrospective cohort study of patients with stage 0 –III melanoma and using data linked between the North Carolina Central Cancer Registry to Medicare, Medicaid, and private health insurance plan claims across the state. We identified 6,496 patients diagnosed between 2004 and 2012 with follow-up through 2017. We categorized the time from diagnostic biopsy to surgical excision as   90 days after ...
Source: Archives of Dermatological Research - October 23, 2020 Category: Dermatology Source Type: research

Treatment strategies for hidradenitis suppurativa: real-life data from a tertiary Greek hospital
AbstractHidradenitis suppurativa (HS) is a difficult-to-treat chronic relapsing skin disease, which greatly impacts the quality of life. To bring forward real-life challenges in the decision-making process regarding HS treatment. A retrospective observational study was performed with treatment-related data derived from the HS archive of tertiary hospital-based First Department of Dermatology and Venereology of Aristotle University, Greece. Data were available for 121 patients, 63 men (52.7%) and 58 women (47.93%) with a mean age of 38  years. Doxycycline 100 mg twice daily for 1–2 weeks and then once d...
Source: Archives of Dermatological Research - October 22, 2020 Category: Dermatology Source Type: research

Sub-classification of Hidradenitis suppurativa: a cross-sectional study
AbstractThe typical Hidradenitis Suppurativa (HS) patient is a young woman with axillary and groin involvement, but the spectrum of the disease presentation is broad and no internationally acknowledged sub-classification of the disease exists to date. It is however speculated that different, yet unidentified, subtypes may respond differently to different treatments or carry a different prognosis. Classification according to self-reported clinically meaningful outcomes for patients offer practical advantages. Our objective was to build an empirical framework for sub-classification of HS patients based on the frequency of HS...
Source: Archives of Dermatological Research - October 21, 2020 Category: Dermatology Source Type: research

Teledermatology: current indications and considerations for future use
AbstractTelemedicine is one of the most consequential technologies in modern healthcare. In certain situations, it allows for the delivery of care with high quality and minimal difficulty. This is particularly true in dermatology, in which many dermatological conditions can be treated remotely. The burden on dermatology patients has been greatly reduced for certain pathologies due to telemedicine. Health care providers also achieve improved job satisfaction following the convenience of meeting their patients. This paper details select dermatological conditions, and subsequently divides them into those treatable by telemedi...
Source: Archives of Dermatological Research - October 19, 2020 Category: Dermatology Source Type: research

Impact of congenital cutaneous hemangiomas on newborn care in the United States
The objective of this study is to describe the burden of CH on newborn inpatient stays in the United States. Specific aims include characterizing newborns with CH, assessing factors predictive of CH and procedures performed during hospitalization, determining characteristics associated with increased cost of care and length of stay in newborns with CH, and investigating trends in prevalence, length of stay, and cost of care. This is a nationally representative retrospective cohort study (National Inpatient Sample, 2009 –2015). Sociodemographic factors associated with CH and risk factors for increased cost of care/len...
Source: Archives of Dermatological Research - October 19, 2020 Category: Dermatology Source Type: research

Clinical and dermoscopic features of Fibroepithelioma of Pinkus: case series with an emphasis on hypopigmented to pink lines intersecting at acute angles
AbstractFibroepithelioma of Pinkus (FEP) is a subtype of basal cell carcinoma (BCC) that can clinically resemble intradermal nevi (IDN) and fibromas. We performed a retrospective review of consecutively biopsied lesions confirmed to be FEP on histopathology diagnosed from January 1, 2008 to April 8, 2019. Clinical (n = 48), contact non-polarized dermoscopy (NPD) (n = 44), and contact polarized dermoscopy (PD) (n = 22) images from 36 patients were reviewed. Mean age was 64.5 years (SD 15.1 years, range 24–86 years) at diagnosis of first FEP lesion. Most lesions ...
Source: Archives of Dermatological Research - September 24, 2020 Category: Dermatology Source Type: research

The use of retinoic acid in association with microneedling in the treatment of epidermal melasma: efficacy and oxidative stress parameters
This study aimed to evaluate the effectiveness of isolated treatment with retinoic acid and its combination with the microneedling technique in facial melasma, seeking to associate these results with possible oxidative damage. This is a blinded randomized clinical trial with 42 women with facial melasma (skin phototype I –IV), randomized into Group A (microneedling and 5% retinoic acid) or Group B (5% retinoic acid alone). Four procedures were applied with 15 days intervals (4 blood collections). Clinical improvement was assessed using the Melasma Area Severity Index (MASI). Serum oxidative stress levels were ev...
Source: Archives of Dermatological Research - September 24, 2020 Category: Dermatology Source Type: research

Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients
AbstractObjectiveTo analyze the prognosis of cutaneous adnexal malignancies, survival relative to surgical management, and utility of lymph-node biopsy.DesignPopulation-based study of the SEER-18 database from 1975 to 2016.Participants7591 patients with sweat gland carcinoma, hidradenocarcinoma, spiradenocarcinoma, sclerosing sweat duct tumor/microcystic adnexal tumor (SSDT/MAC), porocarcinoma, eccrine adenocarcinoma, and sebaceous carcinomaResultsFive-year OS ranged from 68.0 to 82.6%, while 5-year DSS ranged from 94.6 to 99.0%. The majority of patients were treated with narrow (42.4%) or wide local excision (16.9%). DSS ...
Source: Archives of Dermatological Research - September 22, 2020 Category: Dermatology Source Type: research

Advanced keratinocyte skin cancer is a tumor with considerable disease burden and aggressiveness
AbstractIn a 2013 study published in this Journal, Dacosta Byfield et al. used MediCare data to extract reliable estimations of the incidence (I = 6.16) and prevalence (P = 10.31) rates of advanced keratinocyte skin cancer (aKSC) per 100,000 US population. These data unmask a considerable disease burden of aKSC (tumor stages ≥ 3) compared to the corresponding projected SEER predictions in 2019 of all invasive cases (tumor stages ≥ 1). According to it s incidence, aKSC ranks 19th out of 29 major SEER registered neoplasms and has an average disease duration of 1.6...
Source: Archives of Dermatological Research - September 22, 2020 Category: Dermatology Source Type: research

Demographic features and changing incidence and presentation of Merkel cell carcinoma in a retrospective single-center case series
AbstractMerkel cell carcinoma (MCC) is an uncommon aggressive cutaneous neuroendocrine tumor with high mortality. The purpose of this study is to describe the clinical correlates of MCC and identify changing trends over time using a retrospective chart review of 113 cases in a single tertiary center pathology database from 1997 to 2015. MCC occurred mostly in the elderly (median age 77  years), more often in males (n = 60, 53%), was most commonly located on the head and neck region (n = 63, 56%), and most commonly presented on the left side of the body (n = 59, 52%). Overall, ...
Source: Archives of Dermatological Research - September 21, 2020 Category: Dermatology Source Type: research

Upregulation of DJ-1 expression in melanoma regulates PTEN/AKT pathway for cell survival and migration
This study suggests that DJ-1 may be a potential target for the treatment of melanoma. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - September 20, 2020 Category: Dermatology Source Type: research

Cutaneous manifestations of COVID-19
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - September 20, 2020 Category: Dermatology Source Type: research

Engraftment of bioengineered three-dimensional scaffold from human amniotic membrane-derived extracellular matrix accelerates ischemic diabetic wound healing
AbstractHuman amniotic membrane (HAM) is traditionally used for the treatment of non-healing wounds. However, high density of HAM-matrix (HAM-M) diminishes cellular contribution for successful tissue regeneration. Herein we investigated whether a bioengineered micro-porous three-dimensional (3D) HAM-scaffold (HAM-S) could promote healing in ischemic wounds in diabetic type 1 rat. HAM-S was prepared from freshly decellularized HAM. Then, 30  days after inducing diabetes, an ischemic circular excision was generated on rats’ skin. The diabetic animals were randomly divided into untreated (Diabetic group), engrafted...
Source: Archives of Dermatological Research - September 16, 2020 Category: Dermatology Source Type: research

Sunscreen application technique amongst patients with a history of skin cancer
AbstractBackgroundData on how patients with a history of skin cancer apply sunscreen are lacking.ObjectiveTo characterize (1) gender differences in sunscreen application technique (quantity used, anatomic site coverage, and time allocated) and (2) differences in sunscreen application to unaffected skin versus previous skin cancer sites.MethodsSubjects with a history of skin cancer were asked to apply sunscreen to their head as they normally would. The amount of sunscreen used and application time were recorded. Before and after photos were taken. Using Wood ’s lamp lighting, an anatomic site coverage score was rated ...
Source: Archives of Dermatological Research - September 14, 2020 Category: Dermatology Source Type: research

Ablative fractional laser treatment of hypertrophic burn and traumatic scars: a systematic review of the literature
AbstractHypertrophic scars (HTS) following burns and other trauma and are associated with significant functional and psychosocial impairment. Ablative fractional lasers (AFLs) are increasingly being applied in the treatment of HTS supported by a rapidly expanding multidisciplinary base of literature. The multidisciplinary authors sought to evaluate existing literature, provide context and identify gaps, and make recommendations for a path forward. A systematic review was conducted to identify literature pertinent literature through September 2019. Retrospective cohort, randomized controlled trials, quasi-randomized control...
Source: Archives of Dermatological Research - September 13, 2020 Category: Dermatology Source Type: research

Cutaneous manifestations of COVID-19: report of three cases
AbstractCoronavirus disease 2019 (COVID-19) shows rapid spread around the world. Its classic presentation is a respiratory illness. However, cutaneous manifestations have rarely been described as the first clinical manifestation in patients with this infection. The aim of this article is to describe cutaneous manifestations in patients with COVID-19 through three case reports. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - September 6, 2020 Category: Dermatology Source Type: research

Botulinum toxin type A versus 5-Fluorouracil in treatment of keloid
AbstractMost therapeutic approaches for keloids remain clinically unsatisfactory. In the last years, intralesional botulinum toxin-A (IL BTX-A) was proposed for treatment of keloids. Our aim of the study was to compare the clinical efficacy of IL BTX-A and IL 5-Fluorouracil (IL 5-FU) in treatment of keloids. A total of 50 patients with keloids were included in the study, 22 patients (with 26 keloids) were treated with IL BTX-A monthly for up to 6  months and other 22 patients (with 27 keloids) were treated with IL 5-FU weekly for up to 6 weeks, while the remaining 6 patients, each having multiple keloids, were tr...
Source: Archives of Dermatological Research - September 4, 2020 Category: Dermatology Source Type: research

Comparison between single- versus double-spin prepared platelet-rich plasma injection in treatment of female pattern hair loss: clinical effect and relation to vascular endothelial growth factor
AbstractPlatelet-rich plasma (PRP) provides a  treatment option for female pattern hair loss (FPHL). However, the most suitable preparation method is not yet clear. The primary aim is to compare between the efficacy of single- versus double-spin PRP preparation injection in the treatment of FPHL, while the secondary aim is to assess the relati onship between vascular endothelial growth factor (VEGF) concentrations in different prepared PRP preparations (pre- and post-activation) and the obtained treatment results. 15 female patients with FPHL were subjected to intradermal injection of double-spin prepared PRP into the...
Source: Archives of Dermatological Research - September 4, 2020 Category: Dermatology Source Type: research

Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
AbstractVarious treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2  years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver tr...
Source: Archives of Dermatological Research - September 4, 2020 Category: Dermatology Source Type: research

Squamous cell carcinoma in situ upstaging is not frequent in the nail unit: a tertiary cancer center experience
AbstractSquamous cell carcinoma in situ (SCCIS) of the nail unit is a complex malignancy; with little understanding of rate of upstaging or occult invasion in these patients. We sought to evaluate the rate of upstaging in nail unit SCCIS after Mohs micrographic surgery (MMS). Retrospective review of 346 patients who referred for and underwent MMS for biopsy proven SCCIS on the hands and feet between January 1, 2000 and December 30, 2019. Only cases in the nail unit were included. Clinical, surgical details, histopathological features, HPV status, and rate of upstaging were recorded. Thirty-one cases met the inclusion crite...
Source: Archives of Dermatological Research - September 3, 2020 Category: Dermatology Source Type: research

Clinical evaluation of efficacy and tolerability of cysteamine 5% cream in comparison with tranexamic acid mesotherapy in subjects with melasma: a single-blind, randomized clinical trial study
This study was aimed at evaluating the efficacy of Tranexamic Acid (TA) mesotherapy versus cysteamine 5% cream in the treatment of melasma. This single-blind, randomized clinical trial was conducted among 54 subjects between 2018 and 2019. Cysteamine 5% cream group was instructed to apply the cream on the melasma lesions 30  min before bed for 4 consecutive months. Conversely, 0.05 mL (4 mg/mL) TA mesotherapy was performed by a physician every 4 weeks until 2 months. The severity of melasma was evaluated using both Dermacatch® device and the modified Melasma Area Severity Index (mMASI). The mos...
Source: Archives of Dermatological Research - September 1, 2020 Category: Dermatology Source Type: research

Anxiety sensitivity and social anxiety in adults with psychodermatological symptoms
This study demonstrates replication, and the findings suggest heightened concerns about the negative consequences related to visible skin condition s may worsen social anxiety symptoms in individuals with psychodermatological conditions. Despite limitations, this study informs the conceptualization of co-occurring psychological and dermatological conditions and highlights the need to evaluate the efficacy of brief AS interventions among patient s with psychodermatological conditions. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 27, 2020 Category: Dermatology Source Type: research

Optical imaging guided- ‘precision’ biopsy of skin tumors: a novel approach for targeted sampling and histopathologic correlation
AbstractDermoscopy and reflectance confocal microscopy (RCM) are two noninvasive, optical imaging tools used to facilitate clinical diagnosis. A biopsy technique that produces exact correlation with optical imaging features is not previously reported. To evaluate the applications of a novel feature-focused ‘precision biopsy’ technique that correlates clinical–dermoscopy–RCM findings with histopathology. This was a prospective case-series performed during August 2017 and June 2019 at a tertiary care cancer. We included consecutive patients requiring a precise dermoscopy–RCM–histopathologi...
Source: Archives of Dermatological Research - August 24, 2020 Category: Dermatology Source Type: research

Predicting outcomes following second intent healing of periocular surgical defects
ConclusionsThis retrospective study suggests that periorbital defects in all locations with area less than 1.04 cm2 heal well by SIH. In this cohort, larger lesions on the medial canthus healed with worse outcomes. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 23, 2020 Category: Dermatology Source Type: research

Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study
In this study, we aimed to investigate the hematological and inflammatory parameters in patients with vitiligo and to evaluate their possible relationship with disease severity. The parameters including MHR, MLR, NLR, PLR, MPV, and PCT were retrospectively investigated in patients with vitiligo and healthy controls. Disease severity was evaluated using the vitiligo extent tensity index (VETI) score. A total of 180 patients with vitiligo, and age –gender-matched 180 healthy controls were enrolled in the study. MHR, MLR, PLR, PCT values were found to be significantly higher in patients with vitiligo (p 
Source: Archives of Dermatological Research - August 19, 2020 Category: Dermatology Source Type: research

Characteristics of hospitalized dermatomyositis patients with underlying malignancy: a nationally representative retrospective cohort study
ConclusionsDM inpatients with malignancy display numerous differences compared to DM inpatients without malignancy. Further research characterizing hospitalized DM patients is warranted in order to optimize work-up and treatment guidelines for these patients. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 16, 2020 Category: Dermatology Source Type: research

Limited sun safety education in high school curricula: a pilot study and call to action
AbstractAlthough tanning is widespread, the use of both indoor and outdoor tanning most often begins in adolescence and young adulthood and is more prevalent in adolescents and young adults (AYA) than any other age group. Despite this, information regarding sun safety education in high school curricula is limited. In this pilot study, we sought to characterize the presence of education regarding sun safety in the curricula of US public high schools. Cross-sectional survey administered to random sample stratified by state of public high schools in the US. 31 high schools from 22 states submitted survey responses (Fig. 1). T...
Source: Archives of Dermatological Research - August 13, 2020 Category: Dermatology Source Type: research

The effects of tacrolimus plus phototherapy in the treatment of vitiligo: a meta-analysis
The objective of this meta-analysis was performed to compare the effects of tacrolimus plus phototherapy in the treatment of patients with vitiligo. Relevant studies were identified by searching PubMed, Embase, and Web of Science databases. The main outcomes of interest included excellent response ( ≥ 75% repigmentation), good response (50–75% repigmentation), moderate response (25%–50% repigmentation), and poor response (
Source: Archives of Dermatological Research - August 11, 2020 Category: Dermatology Source Type: research

Patient education in Mohs surgery: a review and critical evaluation of techniques
ConclusionRegardless of the education technique utilized, no singular technique entirely replaces the traditional in-person discussion. Having access to multiple modalities can be beneficial for patients, allowing them options to choose their preferred method(s) of education. MMS is a difficult topic to conceptualize, and further research into educational techniques is needed to provide clear guidelines for Mohs surgeons. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 11, 2020 Category: Dermatology Source Type: research

Immunohistochemical study of perforin and apoptosis stimulation fragment ligand (FasL)in active vitiligo
In conclusion, the significant expression of perforin and FasL in the epidermis and dermis of both perilesional and non-lesional skin of active vitiligo patients suggests the role of cytotoxic granules and apoptotic cell death pathways in the pathogenesis of active vitiligo. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 11, 2020 Category: Dermatology Source Type: research

Effects of health beliefs, social support, and self-efficacy on sun protection behaviors among medical students: testing of an extended health belief model
AbstractSun protection behaviors (SPB) are important modifiable risk factors for skin cancer. As the most common malignancies in the world, skin cancers account for significant morbidity, mortality, and economic burden. Physicians play a key role in educating patients about proper SPB. Medical education provides the foundation for physician understanding of SPB and future patient education. The Health Belief Model (HBM) is a theoretical model that offers constructs to help explain health behaviors. This cross-sectional study examined a convenience sample of 186 medical student to assess their engagement in SPB through the ...
Source: Archives of Dermatological Research - August 10, 2020 Category: Dermatology Source Type: research

Depressive symptoms and insecure attachment predict disability and quality of life in psoriasis independently from disease severity
AbstractPsoriasis is a multisystemic inflammatory disease with a significant burden in terms of disability and reduced quality of life. The interrelations between disease severity, psychological well-being, and disability and/or health-related quality of life (HRQOL) of psoriatic patients are not fully understood. The aim of the study was to assess the relative role of disease severity, depressive symptoms, and insecure attachment in predicting disability and HRQOL in 105 patients with psoriasis. Objective measures of disease severity included the Body Surface Area (BSA), the Psoriasis Area and Severity Index (PASI), and t...
Source: Archives of Dermatological Research - August 9, 2020 Category: Dermatology Source Type: research

Metastatic head and neck cutaneous basal cell carcinomas: a retrospective observational study
AbstractCutaneous basal cell carcinoma is usually an indolent and slow-growing tumor with potential for local invasion and recurrence; however, metastatic events are exceedingly rare. The annual incidence of metastasis is estimated to range between 0.00281 and 0.05%. A retrospective search in the pathology database of a single tertiary institution was performed in the period between 1999 to 2019. Primary cutaneous metastatic basal cell carcinomas had paraffin blocks and glass slides retrieved. A total of 8673 cases was identified. The overall prevalence of metastatic tumors was 0.05% (4/8673). The median patient ’s a...
Source: Archives of Dermatological Research - August 9, 2020 Category: Dermatology Source Type: research

Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
The objective of this study was to assess the prevalence of premalignant lesions, i.e., actinic keratosis and Bowen ’s disease, as well as basal cell carcinoma (BCC) and cutaneous melanoma (CM) among patients with cutaneous squamous cell carcinoma (cSCC). Pathology database search was performed to identify all cSCC patients diagnosed in the Pirkanmaa region of Finland in 2006–2015. Details of the patients and tumours were obtained through medical record review. The cohort consisted of 774 patients with 1131 cSCC tumours. Overall 559 patients (72%) had premalignant lesions. A total of 316 patients (41%) had BCC ...
Source: Archives of Dermatological Research - August 8, 2020 Category: Dermatology Source Type: research

Effects of climate and air pollution factors on outpatient visits for eczema: a time series analysis
This study aimed to determine an association between environmental factors and outpatient clinic visits for eczema. We collected data on dermatology clinic outpatient visits for eczema between January 2013 and July 2019. Data concerning environmental factors during this period were collated using national air quality network and air monitoring measurement parameters, namely barometric pressure, relative humidity, air temperature, and air pollutant concentrations, such as sulfur dioxide (SO2) and particulate matter (PM10). A distributed lag nonlinear model was used to investigate the relationship among eczema, environmental...
Source: Archives of Dermatological Research - August 8, 2020 Category: Dermatology Source Type: research

Innovation interest within dermatology: a needs assessment for novel thought processes
The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional survey was conducted among attendees of the Advancing Innovation in Dermatology Forum in Feburary 2019. The second survey was conducted among trainees (resident/fellows) and faculty dermatologists at Brown, Emory, Iowa, Stanford, and Vanderbilt Universities between June and November 2019. Demographic data were collected, as well as factors involved with identifying problems, developing solutions, training in innovation, and perceived barriers to innovation. In the f...
Source: Archives of Dermatological Research - August 8, 2020 Category: Dermatology Source Type: research

Association study indicates combined effect of interleukin-10 and angiotensin-converting enzyme in basal cell carcinoma development
In this study, three functional DNA polymorphisms affecting gene expression were investigated in 54 BCC patients and 111 healthy controls: interleukin-1b (IL-1b) +3953C/T, interleukin-10 (IL-10) − 1082G/A and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms. Significant increase of the variant alleles was observed in IL-10 − 1082G (P = 0.019) and in ACE D (P = 0.003) in BCC patients in comparison to controls. Multivariate logistic regression models evaluated the contribution of homozygous and heterozygous variant polymorphisms to the risk for BCC d...
Source: Archives of Dermatological Research - August 7, 2020 Category: Dermatology Source Type: research

Multidisciplinary surgical treatment approach for dermatofibrosarcoma protuberans: an update
The objective of this study is to investigate the oncologic and reconstructive benefits of employing a multidisciplinary  two-step approach to the treatment of DFSP. A retrospective review was conducted using a prospectively collected database of all patients who underwent resection and reconstruction of large DFSPs by a multidisciplinary team, including a Mohs micrographic surgeon, surgical oncologist, dermatopathol ogist, and plastic and reconstructive surgeon, at one academic institution from 1998–2018. Each patient underwent Mohs micrographic surgery for peripheral margin clearance (Step 1) followed by ...
Source: Archives of Dermatological Research - August 6, 2020 Category: Dermatology Source Type: research

Oral mycophenolate mofetil as a stabilizing treatment for progressive non-segmental vitiligo: results from a prospective, randomized, investigator-blinded pilot study
AbstractDexamethasone oral mini-pulse (OMP) is commonly used to halt progression of non-segmental vitiligo (NSV). There is an unmet need for non-phototherapy, non-corticosteroid therapeutic options for stabilizing actively spreading NSV. To assess the efficacy of oral mycophenolate mofetil in stabilizing active NSV in comparison to OMP. In this prospective, randomized, investigator-blinded study, 50 patients of active vitiligo [baseline vitiligo disease activity (VIDA) score 4] were randomized into two groups in 1:1 ratio. Group A received oral dexamethasone (2.5  mg on two successive days a week) and group B received...
Source: Archives of Dermatological Research - July 30, 2020 Category: Dermatology Source Type: research

Effects of different doses of abobotulinumtoxinA for the treatment of anterior gingival smile
The objective of the study was to compare the reduction of gingival exposure using three different doses of abobotulinumtoxinA (ABO) in patients with different severities of anterior GS, and to assess treatment safety and patients ’ satisfaction. A prospective, single-center, randomized, double-blind study was conducted. Mild GS (2 to 
Source: Archives of Dermatological Research - July 27, 2020 Category: Dermatology Source Type: research

Definitions, survey methods, and findings of patient satisfaction studies in teledermatology: a systematic review
We examined domains of satisfaction, survey method, study characteristics (including patient population, country, age, study design and evidence score), findings and statistical comparisons. We thoroughly reviewed 23 studies. Definitions of satisfaction varied, but all concluded patients were satisfied with the live-interactive and store-and-forward modalities. The studies reveal that store-and-forward is appropriate for clinicians with established patients who require regular follow-up. Verified areas of care include treatment of chronic conditions, topical skin cancer therapy, wound monitoring, and post-procedural follow...
Source: Archives of Dermatological Research - July 27, 2020 Category: Dermatology Source Type: research

Bidirectional association between alopecia areata and thyroid diseases: a nationwide population-based cohort study
In conclusion, our study found a bidirectional association between AA and thyroid diseases, suggesting shared biological mechanisms underlying these two diseases. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 22, 2020 Category: Dermatology Source Type: research

Hidradenitis suppurativa is associated with acne keloidalis nuchae: a population-based study
AbstractThe association between acne keloidalis nuchae (AKN) and hidradenitis suppurativa (HS) is yet to be investigated. To determine the link between AKN and HS using a large computerized health maintenance database. A cross-sectional study design was used to assess the prevalence of HS in patients with AKN and in control participants matched by age, sex, and ethnicity. A total of 2677 participants with AKN and 13,190 control participants were studied. An increased prevalence of HS was observed in the AKN group compared to the control group (1.0% vs. 0.3%, respectively; OR, 3.6; 95% CI 2.2 –5.8;P  
Source: Archives of Dermatological Research - July 15, 2020 Category: Dermatology Source Type: research

Current concepts and approaches to merkel cell carcinoma
This article reviews the most current literature on the surgical and medical management of MCC. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 13, 2020 Category: Dermatology Source Type: research

Association of bullous pemphigoid and comorbid health conditions: a case –control study
ConclusionsBullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 9, 2020 Category: Dermatology Source Type: research

Optimizing care for psoriatic patients requiring systemic therapies: how will COVID-19 disease transform risk perceptions?
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 8, 2020 Category: Dermatology Source Type: research

P53 staining index and zonal staining patterns in actinic keratoses
AbstractActinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor the histological grade of dysplasia seems valid predictors of aggressive potential of AKs. Instead, the mutational status in AKs appears to predict well the clinical course. TP53 gene mutations result in a non-functional protein resistant to degradation, thus immunohistochemical staining for p53 can suggest mutation status. Increased p53 was associated with progression from AK to squamous cell carcinoma. To investigate how the intensity of p53 staining (p53 stainin...
Source: Archives of Dermatological Research - July 7, 2020 Category: Dermatology Source Type: research

Association of inflammatory skin diseases with venous thromboembolism in US adults
The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis is associated with VTE in US adults. Data were analyzed from the 2002 –2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N = 72,512,581 adults, including 1,389,292 with VTE). In multivariable logistic regression models including age, sex, insurance, household income and race/ethnicity, hospitalization for AD (adjusted odds ratio [95% confidence intervals] 1.22 [1.17–1.27]), pemphigus (1.96 [1.68–2.28]) and pemp higoid (1.64 [1.47&nda...
Source: Archives of Dermatological Research - July 7, 2020 Category: Dermatology Source Type: research

Evaluating antitumor activity of antiglypican-3 therapy in experimentally induced skin cancer in mice
In conclusion, anti-GPC3 produced anti-tumor effects against skin cancer, which can be explained by reduction in both inflammatory and apoptotic pathways. Targeting GPC3 is a promising therapeutic approach for skin cancer.Graphic abstract (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 6, 2020 Category: Dermatology Source Type: research