Reporting regression with melanoma in situ: reappraisal of a potential paradox
AbstractMelanoma in situ (MIS) is a form of radial growth phase melanoma in which the proliferation of malignant cells is confined to the epidermis. Histologic features are invaluable in recognition of MIS. Regression occurs when the host ’s immune system attacks the primary melanocytic tumor cells via tumor infiltrate lymphocytes, resulting in a fibrotic component. Various criteria have been proposed to assess the extent of histologic regression. Some authors define regression based on histologic features of the dermis, which is i nappropriate for MIS. Specific dermatoscopic findings of regression in MIS have been r...
Source: Archives of Dermatological Research - July 6, 2020 Category: Dermatology Source Type: research

Psoriasis severity matters when dealing with all-cause mortality in psoriasis patients: a record linkage analysis in Northern Italy
Abstract Psoriasis has been linked with several comorbidities and increased all-cause mortality compared with the general population. Data are still limited concerning mortality especially from Southern European countries. Between January 2012 and December 2018, we conducted a retrospective cohort study on psoriasis patients and population controls in Northern Italy. Through record linkage of health-care databases, psoriasis cases were identified, and their morbidity and mortality were compared with the general population. The Charlson index was used as an index of comorbidities. Standardized mortality ratios (SMR) were es...
Source: Archives of Dermatological Research - July 5, 2020 Category: Dermatology Source Type: research

The inpatient burden and comorbidities of pyoderma gangrenosum in adults in the United States
This study demonstrated a substantial and increasing inpatient burden of PG in the United States, with considerable disability and mortality risk, multiple comorbid health disorders, and costs. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 3, 2020 Category: Dermatology Source Type: research

Reliable test of clinicians ’ mastery in skin cancer diagnostics
AbstractDifferentiating between benign and malignant skin lesions can be very difficult and should only be done by sufficiently trained and skilled clinicians. To our knowledge there are no validated tests for reliable assessments of clinicians ’ ability to perform skin cancer diagnostics. To develop and gather validity evidence for a test in skin cancer diagnostics, a multiple-choice questionnaire (MCQ) was developed based on informal interviews with seven content experts from five skin cancer centers in Denmark. Validity evidence for t he test was gathered from May until July 2019 using Messick’s validity fra...
Source: Archives of Dermatological Research - June 28, 2020 Category: Dermatology Source Type: research

Excessive cleansing: an underestimating risk factor of rosacea in Chinese population
In conclusion, excessive cleansing habits were substantial risk factors for the incidence and progression of rosacea in the Chinese population. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - June 27, 2020 Category: Dermatology Source Type: research

Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under “pathological” conditions ex vivo
AbstractImpaired cutaneous wound healing remains a major healthcare challenge. The  enormity of this challenge is compounded by the lack of preclinical human skin wound healing models that recapitulate selected key factors underlying impaired healing, namely hypoxia/poor tissue perfusion, oxidative damage, defective innervation, and hyperglycaemia. Since organ-cultured human skin already represents a denervated and impaired perfusion state, we sought to further mimic “pathological” wound healing conditions by culturing experimentally wounded, healthy full-thickness frontotemporal skin from three healthy fe...
Source: Archives of Dermatological Research - June 22, 2020 Category: Dermatology Source Type: research

Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis
In conclusion, an increased serum level of resistin associated with increased endothelin-1 and fractalkine level and decreased adiponectin level may indicate a significant role of the adipose tissue in the development and progression of vascular abnormalities in patient s with systemic sclerosis. Fractalkine and galectin-3 may participate in promoting and exacerbating the fibrotic process in SSc. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - June 20, 2020 Category: Dermatology Source Type: research

Vitamin D, autoimmunity and immune-related adverse events of immune checkpoint inhibitors
AbstractIn addition to its quintessential role in bone homeostasis, vitamin D also plays an important role in regulating the immune system. As such, many studies have demonstrated the therapeutic benefit of vitamin D in treating autoimmune diseases. This immunomodulatory activity of vitamin D has recently attracted more attention due to the rapid development of immunotherapies for cancers, including melanoma. Patients on cancer immunotherapies can suffer from immune-related adverse events (irAEs), which can involve any organ system and range from common dermatological reactions to extremely severe cases of fatal myocarditi...
Source: Archives of Dermatological Research - June 9, 2020 Category: Dermatology Source Type: research

Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris
AbstractThe treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes resistant nature delineate the need for alternative therapies. Therefore, over the past decade, phototherapy has been introduced for the treatment of acne, such as pulsed dye lasers (PDLs) and photodynamic therapy (PDT). The aim of this study was to compare the safety and efficacy of PDL and methylene blue-mediated photodynam...
Source: Archives of Dermatological Research - May 24, 2020 Category: Dermatology Source Type: research

Follow-up of skin lesions during the evolution of COVID-19: a case report
AbstractThe disease caused by the new coronavirus (COVID-19) has many systemic manifestations affecting the upper airways, lungs, gastrointestinal tract and inducing hematological repercussions. With the evolution of the pandemic, skin lesions were observed. However, there is little information  about the evolution of the lesions at this moment. The authors report a case of a patient who had more than one exposure to the coronavirus during the evolution of the disease and manifested different types of edematous lesions. The lesions started in the prodromal period and changed their present ation and localization during...
Source: Archives of Dermatological Research - May 14, 2020 Category: Dermatology Source Type: research

Why it ’s hard to see a dermatologist for a skin exam: the patient perspective
AbstractBackgroundIn-office skin exams are recommended at least annually for patients who are diagnosed with a basal cell carcinoma or squamous cell carcinoma, but it is unknown what proportion of these patients are receiving skin exams. There are a multitude of reasons why patients have difficulty getting skin exams.AimTo assess the proportion of patients at our institution who received a skin exam in the 12  months following removal of a basal cell carcinoma or squamous cell carcinoma by Mohs micrographic surgery and to assess the barriers to care that patients faced in receiving a skin exam.MethodsWe conducted an I...
Source: Archives of Dermatological Research - May 12, 2020 Category: Dermatology Source Type: research

Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis
The objective of this study is to determine rates and predictors of cardiovascular screening among patients with psoriasis, AD, and hidradenitis in the United States. Data from the 2006 –2015 National Ambulatory Medical Care Survey were analyzed, including 67,581 pediatric and 322,957 adult outpatient visits. Overall, blood pressure screening was performed less commonly in psoriasis (36.4% [31.0–42.2%]) and AD (41.9% [39.3–44.7%] of visits) compared to other visits (62.5% [61 .5–63.6%]) (P 
Source: Archives of Dermatological Research - May 11, 2020 Category: Dermatology Source Type: research

Outpatient healthcare utilization and prescribing patterns for herpes zoster in United States adults
The objective of this study is to characterize trends in HZV utilization, racial disparities, and treatment patterns in the United States. Data from the 1993 –2015 National Ambulatory Medical Care Survey were analyzed, including 15,400,000 weighted primary acute HZV visits in adults. Overall, the weighted frequency (95% confidence interval) of HZV visits increased from 1993–1998 to 2007–2015 (1,269,815 [565,455–1,974,175]–8,017,911 [6,424,491– 9,611,331],P = 0.0001). HZV visits were associated with African–American (38.8% [35.8–41.7%] vs. 8.2% [7.4–9.0%]) ...
Source: Archives of Dermatological Research - May 10, 2020 Category: Dermatology Source Type: research

Preventing adverse cutaneous reactions from amplified hygiene practices during the COVID-19 pandemic: how dermatologists can help through anticipatory guidance
AbstractThe COVID-19 pandemic has swept the globe with more than 2,000,000 confirmed cases of SARS-CoV-2 infection in 184 countries and territories. According to the Centers for Disease Control and Prevention (CDC), two crucial actions can reduce the risk of person-to-person viral transmission: frequent hand washing and surface decontamination with specific environmental protection agency (EPA)-registered disinfectants. As hygiene recommendations evolve during the COVID-19 pandemic and community members adopt changing practices, dermatologists are likely to see a rise in adverse cutaneous reactions from prolonged irritant ...
Source: Archives of Dermatological Research - May 9, 2020 Category: Dermatology Source Type: research

Thickness of carotid artery intima is an independent risk factor for psoriasis
AbstractPsoriasis (PsO) has been associated with lipoprotein abnormalities, visceral adiposity, atherosclerosis, and coronary artery disease (CAD) in several studies; however, data concerning the risk of psoriasis relevant to these parameters is not well established. We aimed to evaluate the relation between PsO and small dense low-density lipoprotein cholesterol (sd-LDL-C), serum lipid profile (SLP), blood pressures, anthropometric measurements, intima media thickness of the common carotid artery (CIMT), distribution of visceral adipose tissue (VAT; evaluated at 3 different measurement sites including VATa, VATb, VATc) al...
Source: Archives of Dermatological Research - May 9, 2020 Category: Dermatology Source Type: research

Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model
This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1 (control) were untreated and unexposed; Group 2 were untreated and exposed to O3 (0.4  ppm, 4 h); Group 3 were pretreated with WEL-DS and unexposed; Group 4 were pretreated with WEL-DS and exposed to O3 (0.4  ppm, 4 h). Pretreated tissues were topically treated with 20 uL of WEL-DS and incubated for up to 20 h at 37 °C [humidified, 5% carbon dioxide (CO2)]. After 24  h, tissues were re...
Source: Archives of Dermatological Research - May 8, 2020 Category: Dermatology Source Type: research

Sentinel lymph node biopsy for high-thickness cutaneous squamous cell carcinoma
In this study, the role of the SLNB in lymph node status and survival was analyzed. Retrospectively, 720 patients with high-risk squamous cell carcinoma (tumor thickness  >  5 mm) were examined. 150 patients agreed to SLNB, 570 patients did not undergo histologic confirmation of lymph node status and were included directly in follow-up. In 101 patients, a sentinel lymph node was successfully marked and extirpated, followed by regular follow-up examinations.A total of 11.11% of the patients showed lymph node metastasis in the course of their treatment, with no difference in the proportion of patients i...
Source: Archives of Dermatological Research - May 8, 2020 Category: Dermatology Source Type: research

Distance learning in the era of COVID-19
AbstractThe novel coronavirus (SARS-CoV-2) pandemic has necessitated a dramatic shift in how our dermatology residents and fellows are educated. Distance or online learning has become the norm, and several national and international academic societies have combined resources to assure  that continuing medical education occurs during this difficult time. The purpose of this communication is to review select online resources available to dermatology trainees and to encourage our colleagues to continue to advance our specialty through distance learning. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 8, 2020 Category: Dermatology Source Type: research

Tumour-infiltrating lymphocyte and histological regression in primary melanoma
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 7, 2020 Category: Dermatology Source Type: research

Correction to: Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity
Two of the references included in this review concern antigens derived from the fungusMalassezia globosa that have also been found in human sweat. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 30, 2020 Category: Dermatology Source Type: research

Therapeutic efficacy and safety of oral tranexamic acid 250  mg once a day versus 500 mg twice a day: a comparative study
AbstractOral tranexamic acid (TXA) 250  mg twice daily has been used effectively for 4 weeks to 6 months to treat melasma. As relapses are frequent on discontinuation, a minimum effective dose of TXA that can be used safely for long time remains unknown. We compared the efficacy of oral TXA 250 mg once daily and 500 mg twice daily g iven for 16 weeks in 132 (m:f 23:109) adults with melasma. 42 patients in Group-A (TXA 250 mg/d) and 46 patients in Group-B (TXA 500 mg twice/d) completed the study. They were followed up at 4-week interval for percentage reduction in baseline Melasma Are...
Source: Archives of Dermatological Research - April 30, 2020 Category: Dermatology Source Type: research

Incorporation of dermoscopy improves inter-observer agreement among dermatopathologists in histologic assessment of melanocytic neoplasms
This study aimed to determine if integrating dermoscopy with histopathology of melanocytic neoplasms impacts diagnosis and improves inter-observer agreement. We conducted a prospective cohort study in a pigmented lesion clinic. Consecutive melanocytic lesions were identified for biopsy based on atypical gross or dermoscopic features. Standardized immunohistochemistry and levels were ordered on each specimen. The cases were randomized. Three dermatopathologists blinded to the clinical impression assessed each lesion. The cases were then re-randomized and re-assessed with addition of gross clinical and dermoscopic images. In...
Source: Archives of Dermatological Research - April 27, 2020 Category: Dermatology Source Type: research

Prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population
The objectives of this study are to determine the prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population. Between 2014 and 2017, 20,112 people in 343 German companies were examined for the presence of clinical features of hidradenitis suppurativa within the framework of a cross-sectional epidemiological study based on whole-body examinations. In addition, all cutaneous comorbidities were recorded. Point prevalence was calculated and the differences between individuals with and without hidradenitis suppurativa were determined by bivariate analysis. All statistical procedures were...
Source: Archives of Dermatological Research - April 22, 2020 Category: Dermatology Source Type: research

Tacrolimus (FK506) ointment combined with Nb-UVB could activate both hair follicle (HF) and dermal melanocyte precursors in vitiligo: the first histopathological and clinical study
In this study, the histological findings in patients receiving Nb-UVB were compared with those receiving topical tacrolimus combined with Nb-UVB. Twenty patients were recruited and received Nb-UVB treatment. The first ten patients were selected for the combination therapy and instructed to apply tacrolimus 0.1% ointment twice daily on the specified lesion of interest. The remaining ten patients did not receive any other topical treatments. Skin biopsy was performed at baseline from the depigmented area and 2 –3 months post-treatment from the repigmented area. Biopsy specimens were stained with haematoxylin&ndash...
Source: Archives of Dermatological Research - April 17, 2020 Category: Dermatology Source Type: research

Efficacy of health education on treatment of children with atopic dermatitis: a meta-analysis of randomized controlled trials
AbstractAtopic dermatitis (AD) seriously affects the quality of life of children and their families. This meta-analysis aimed to comprehensively analyze health education on the treatment of children with AD and the quality of life of the patient ’s family. A comprehensive search of reference lists in PubMed, Embase, Cochrane Library, Wanfang, CNKI, and VIP databases from inception until April 2018 was performed. The weighted mean difference (WMD) with 95% confidence interval (CI) was calculated. A total of eight randomized controlled tria ls studies were included in the analysis. The heterogeneity among enrolled stud...
Source: Archives of Dermatological Research - April 15, 2020 Category: Dermatology Source Type: research

The “sister test” for selecting appropriate diagnostic interventions and treatments
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 13, 2020 Category: Dermatology Source Type: research

Gender differences in psoriasis: a Swiss online psoriasis survey
AbstractPhysicians ’ and patients’ perspectives can vary significantly. For a long time, physicians considered psoriasis a non-pruritic dermatosis until a survey found pruritus to be the most bothersome symptom among psoriasis patients. In our study, we wanted to get an insight into the factors that affect patient s and evaluate whether gender differences exist. A link of an anonymous online survey (www.fightpsoriasis.ch) with 24 questions was placed on the website of the Swiss Psoriasis and Vitiligo Patient Association (www.spvg.ch) from May 2016 until June 2017. 3164 persons participated in this online survey...
Source: Archives of Dermatological Research - April 12, 2020 Category: Dermatology Source Type: research

Dermal fillers should be renamed skin fillers
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 11, 2020 Category: Dermatology Source Type: research

Trends in emergency department visits due to sunburn and factors associated with severe sunburns in the United States
The objectives of this research were to characterize the burden of sunburn ED visits, investigate predictors of severe sunburns, and evaluate risk factors for increased cost of care in patients presenting to the ED for sunburn. In this  nationally representative cross-sectional study of the National Emergency Department Sample (NEDS, 2013–2015), multivariable models were created to evaluate adjusted odds for sunburn ED visits, seasonal/regional variation in sunburn ED visits, adjusted odds for second and third degree sunburns, and risk factors for increased ED expenditure. 82,048 sunburn ED visits were included ...
Source: Archives of Dermatological Research - April 9, 2020 Category: Dermatology Source Type: research

A cross-sectional survey of prevalence and correlates of sunscreen use among a rural Tri-State Appalachian population
AbstractOver five million people are diagnosed with skin cancers each year. With the sun ’s ultraviolet radiation exposure being the major risk factor for all skin cancers, sunscreen use is a vital preventative measure. However, in the US, sunscreen use remains inadequate. Furthermore, research regarding sunscreen use amongst rural populations has been particularly sparse. To identify the prevalence of sunscreen use and identify correlates thereof, a cross-sectional study was conducted on a sample of patients from rural Tri-State Appalachia. A total of 212 patients participated in this study. Findings showed that you...
Source: Archives of Dermatological Research - April 9, 2020 Category: Dermatology Source Type: research

The polymorphisms of IL-6/STAT3 signaling pathway may contribute to cutaneous T-cell lymphomas susceptibility
AbstractIL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was to examine whether IL-6 cytokine and polymorphisms of IL-6 and STAT3 gene are associated with CTCL susceptibility, stage of disease and pruritus intensity. We compared the IL-6 serum level and the frequency of selected single nucleotide polymorphisms of IL-6 and STAT3 in 106 CTCL and 198 control group u...
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

The utility of PROMIS domain measures in dermatologic care
AbstractPatient-reported outcome (PRO) measures play an important role in clinical care. Currently, a broad-spectrum, validated PRO measure suitable for all dermatology patients, as part of clinical care, does not exist. Patient-reported Outcome Measures Information System (PROMIS) measures track specific domain outcomes across all diseases. To assess the relevance and utility of a computer-adaptive health assessment consisting of three PROMIS domains in routine dermatologic care. This retrospective study evaluated a PROMIS health assessment, consisting of three computer-adaptive test domains (pain interference, anxiety, a...
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

High level of TILs is an independent predictor of negative sentinel lymph node in women but not in men
The objective of this study was to determine whether intensity of tumour-infiltrating lymphocytes (TILs) in a cohort study (N = 4133) is an independent predictor of sentinel lymph node (SLN) status in patients with primary cutaneous melanoma. Of the patients with cutaneous melanoma who resulted negative for nodal metastasis, 50.7% had moderate/marked TILs versus 27.7% among those patients who resulted positive for nod al metastasis. In the multivariate analysis, controlling for sex, age, mitotic rate, ulceration and Breslow, high levels of TILs in primary invasive melanoma was associated with a lower risk of ...
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

The association of chronic spontaneous urticaria (CSU) with anxiety and depression: a nationwide cohort study
In this study we aimed to focus on the association between CSU and anxiety and depression, using an optimized matched controlled design. A nationwide matched control study was conducted using the Clalit Health Services (CHS) database. The study included 12,539 CSU patients and 60,510 age and sex matched controls. Three multiple logistic regression models were conducted to assess the association between CSU and anxiety and depression, while adjusting for age, sex, socioeconomic status (SES), diabetes, obesity, hypertension, and smoking status. A higher frequency of anxiety and depression was found in CSU patients compared t...
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

Quantitative measurement of skin surface oiliness and shine using differential polarized images
This study was designed to set up an imaging device for capturing and enhancing the changes in skin surface oiliness and to clinically and quantitatively, (via image analysis), evaluate varying levels of skin surface oiliness. Mineral oil was used to simulate skin surface oil. 40.5 µL of the mineral oil was applied within a two inch square area of interest on facial skin in twelve steps, from 1 to 40.5 µL, at 40% increments. The results indicate a strong correlation between the quantitative skin surface oiliness measurements and the clinical assessments. This sensitive techn ique has the potential to be utilize...
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

Age-specific physical and mental health status in Italian patients with hidradenitis suppurativa: a comparison with the general population
In conclusion, HS deeply affects patients’ physical and mental status, starting from a very young age. An early intervention is advisable, not only with pharmacological treatment, but also with an appropriate discussion and interaction wit h the patient to focus on the aspects that would reduce the psychosocial impact of their condition. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 8, 2020 Category: Dermatology Source Type: research

Daylight photodynamic therapy for the management of actinic cheilitis
AbstractEarly identification and adequate treatment of actinic cheilitis (AC), which affects the lower lip vermillion and is considered a precursor of squamous cell carcinoma, is mandatory. Photodynamic therapy (PDT) has been successfully used in AC. PDT with the use of daylight (DLPDT) is equally effective and more convenient than the conventional PDT. Data on short and long-term efficacy of DLPDT in AC are limited. Our primary purpose was to assess efficacy of DLPDT in AC as well as safety and tolerance. Twenty-two individuals with histologically confirmed AC received 2 MAL (5-aminolevulinic acid)-DLPDT sessions 1 week a...
Source: Archives of Dermatological Research - April 7, 2020 Category: Dermatology Source Type: research

Pain-less injection: principles and pearls
This article aims to introduce a novel way that minimizes pain and discomfort associated with local anesthetics. It is the authors ’ experience that painless injection is achievable by keeping syringes/needles out of sight, proceeding with injection without pre-procedure warning, and engaging patients in a conversation or simple tasks. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 7, 2020 Category: Dermatology Source Type: research

Trichloroacetic acid model to accurately capture the efficacy of treatments for postinflammatory hyperpigmentation
The objective of this study was to further validate a trichloroacetic acid (TCA)-induced PIH model and compare it to acne-induced PIH using topical bakuchiol, a botanical extract that has been shown to have antimicrobial, anti-inflammatory, antioxidant, and antiacne properties. A prospective, non-randomized clinical trial was conducted on subjects with skin phototypes IV –VI with a history of acne-induced PIH. Subjects applied bakuchiol or vehicle cream twice daily to 2 acne-induced and 2 TCA-induced PIH lesions for 28 days with a third lesion serving as a control in each group. Degree of improvement was defined...
Source: Archives of Dermatological Research - April 6, 2020 Category: Dermatology Source Type: research

Small molecules under development for psoriasis: on the road to the individualized therapies
AbstractPsoriasis is an incurable cutaneous illness characterized by the presence of well-delimited reddish plaques and silvery-white dry scales. So far, there is a limited understanding of its pathogenesis, though recent discoveries on the immunological, genetic and molecular aspects of this disease have significantly contributed to the identification of new targets and the development of novel drugs. Despite these advances, many patients are still dissatisfied, so to improve patient satisfaction, reliability, and clinical outcomes, the individualization of the treatments for this disease becomes a necessity. This review ...
Source: Archives of Dermatological Research - March 14, 2020 Category: Dermatology Source Type: research

Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients
AbstractHidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%,n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%,n = 45), hirsutism (19.3%,n&thi...
Source: Archives of Dermatological Research - March 12, 2020 Category: Dermatology Source Type: research

PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation
In this study, we investigated the expression of PIWIL-2 and piRNAs in normal human skin and epithelial tumors and its regulation during keratinocyte (KC) differentiation. Immunohistochemistry showed that PIWIL-2 was regularly expressed in the epidermis and adnexal tissue with strongest expression in sebaceous glands. Cell culture studies revealed an association of PIWIL-2 expression with the state of differentiated KC. In contrast, the PIWIL-2 expression pattern did not correlate with stem cell compartments or malignancy. piRNAs were consistently detected in KC in vitro by next-generation sequencing and the expression lev...
Source: Archives of Dermatological Research - March 12, 2020 Category: Dermatology Source Type: research

Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment
AbstractBasosquamous carcinoma (BSC) is a malignant and aggressive neoplasm with unclear molecular etiology. It is often misdiagnosed as basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) on biopsy as there are unclear histologic criteria for this neoplasm. It has been interchangeably referred to as metatypical BCC and collision tumor, although these entities are different. On histology, BSC consists of basal cells with areas with nests of squamous cells and an intermediate transition zone. The nature of this transition zone is not clearly defined in literature; however, Ber-EP4 staining is diagnostic for BSC. A g...
Source: Archives of Dermatological Research - March 12, 2020 Category: Dermatology Source Type: research

A novel oxidative stress marker of atopic dermatitis in infants: thiol –disulfide balance
AbstractAtopic dermatitis (AD) is a chronic disease of infancy and its pathogenesis remains unclear. There are recent studies suggesting that oxidative stress could play a role in the pathophysiology of atopic dermatitis. The aim of this study was to evaluate thiol (SH) –disulfide (SS) hemostasis as a new marker of oxidative stress (OS) in infants with atopic dermatitis. Thirty-one infants with AD and 30 healthy infants were included in a prospective, cross-sectional study. PO-SCORAD Index of infants with atopic dermatitis was calculated at the time of sample col lection. Total antioxidant status (TAS), total oxidant...
Source: Archives of Dermatological Research - March 11, 2020 Category: Dermatology Source Type: research

MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis
In this study, it revealed the stabilization of PBX3 mRNA by HuR, thereby boosting PBX3 expression. Lastly, we concluded that miR-4458 and HuR modulated the expression of PBX3 in a competitive manner in melanoma tumorigenesis, which might yield a novel insight into the molecular pathogenesis of melanoma. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 9, 2020 Category: Dermatology Source Type: research

Psoriasin and rs4819554 of IL-17RA gene polymorphism in psoriasis
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 9, 2020 Category: Dermatology Source Type: research

Psoriasis is not a risk factor for dementia: a 12-year nationwide population-based cohort study
This study aims to investigate the risk for dementia in psoriatic patients. This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Research Database between 2000 and 2012. A total of 111,825 patients with psoriasis and 111,825 age-, sex-, and index date-matched controls were recruited. The hazard ratio (HR) for subsequent dementia in patients with psoriasis was analyzed using a Cox model and a Fine-Gray competing risk model. During 1,358,774 person-years of follow-up, 2688 patients developed dementia in the psoriatic cohort, and 2062 developed dementia in the cont...
Source: Archives of Dermatological Research - March 9, 2020 Category: Dermatology Source Type: research

Predictive in silico binding algorithms reveal HLA specificities and autoallergen peptides associated with atopic dermatitis
AbstractAtopic dermatitis (AD) is a skin disease that results from a combination of skin barrier dysfunction and immune dysregulation. The immune dysregulation is often associated with IgE sensitivity. There is also evidence that autoallergens Hom s 1, 2, 3, and 4 play a role in AD; it is possible that patients with specific HLA subtypes are predisposed to autoreactivity due to increased presentation of autoallergen peptides. The goal of our study was to use in silico epitope prediction platforms as an approach to identify HLA subtypes that may preferentially bind autoallergen peptides and are thus candidates for further s...
Source: Archives of Dermatological Research - March 9, 2020 Category: Dermatology Source Type: research

Efficacy of a wound-dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epidermal grafting in stable vitiligo patients: a controlled assessor-blinded clinical study with in vitro bioactivity investigation
In conclusion, MAP could be a novel postoperational wound dressing preventing PIH associated with skin inflammation and injury. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 27, 2020 Category: Dermatology Source Type: research

“Psychodermatology” knowledge, attitudes, and practice among health care professionals
AbstractPsychiatric disorders are prevalent in dermatology patients. Psychodermatology is the body of knowledge at the intersection of psychiatry and dermatology practice. The purpose of this literature review was to assess the knowledge, attitudes, and practices of health care professionals regarding psychodermatology. A search of relevant articles was conducted in PubMed, CINAHL, ERIC, and PsychInfo databases using a comprehensive set of search terms. Studies were included if (1) study participants were health care professionals, (2) studies contained data that could be extracted, and (3) studies were published in peer-r...
Source: Archives of Dermatological Research - February 25, 2020 Category: Dermatology Source Type: research