Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy
This study aims to systematically review randomized controlled trials on topical treatments for actinic keratosis field cancerization, following the PRISMA guidelines. Clinical recommendations were based on the Oxford Centre for Evidence-Based Medicine. We identified 20 original randomized controlled trials for topical cutaneous field therapy. 0.5% 5-Fluorouracil/salicylic acid and 0.5% 5-fluorouracil received a clinical recommendation grade of A, while diclofenac sodium received a clinical recommendation grade of B. Calcipotriol/5-fluorouracil, Imiquimod, sunscreen combination therapies, and tirbanibulin received a recomm...
Source: Archives of Dermatological Research - March 18, 2024 Category: Dermatology Source Type: research

Methodological innovations and stakeholder involvement in core outcome sets for skin diseases: a survey of the C3 working groups
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 18, 2024 Category: Dermatology Source Type: research

Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy
This study aims to systematically review randomized controlled trials on topical treatments for actinic keratosis field cancerization, following the PRISMA guidelines. Clinical recommendations were based on the Oxford Centre for Evidence-Based Medicine. We identified 20 original randomized controlled trials for topical cutaneous field therapy. 0.5% 5-Fluorouracil/salicylic acid and 0.5% 5-fluorouracil received a clinical recommendation grade of A, while diclofenac sodium received a clinical recommendation grade of B. Calcipotriol/5-fluorouracil, Imiquimod, sunscreen combination therapies, and tirbanibulin received a recomm...
Source: Archives of Dermatological Research - March 18, 2024 Category: Dermatology Source Type: research

Methodological innovations and stakeholder involvement in core outcome sets for skin diseases: a survey of the C3 working groups
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 18, 2024 Category: Dermatology Source Type: research

Herpes zoster infection in pregnancy: features and consequences
AbstractHerpes (varicella) zoster (HZ) infection occurs in 4 people per 1000 in the general US population (irrespective of prior varicella infection and vaccination status) each year and has been the subject of scientific inquiry for decades. The consequences of infection are myriad and may depend on the dermatome of involvement as well as host factors such as age, comorbidities, prior treatment or immunization, and immunologic status. Pregnancy is associated with an altered immune and hormonal status in the mother. While maternal HZ infection during pregnancy is not uncommon, the implications for both mother and child are...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Topical steroids or emollients: does order matter?
AbstractTopical corticosteroids, topical steroid-sparing agents, and emollients are all used to treat atopic dermatitis. However, there are no formal guidelines dictating the order and timing in which these topical modalities should be applied. Additionally, the order of application may change drug absorption, efficacy, and distribution. This is especially important for patients with atopic dermatitis. These patients have a dysfunctional skin barrier, which can lead to greater systemic absorption of drugs. Moreover, children already have an increased rate of systemic absorption due to a higher ratio of body surface area to...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis
AbstractNo randomized trials exist to inform the peripheral surgical margins or depth of wide excision for eyelid melanoma. We performed a meta-analysis examining surgical margins and Breslow depth for eyelid melanomas. A systematic review was performed in August 2022 using PubMed, Cochrane, and Medline databases (1/1/1990 to 8/1/2022). Inclusion criteria included studies reporting surgical treatment of primary cutaneous melanomas of the eyelid with reported surgical margins. Ten articles were included. The studies were examined by surgical margin size (group 1:  ≤ 0.5 cm; group 2 >  0.5 cm and ≤ 1.5 ...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Circulating biomarkers of oxidative stress in people with acne vulgaris: a systematic review and meta-analysis
This study aimed to explore the potential correlation between acne vulgaris and circulating oxidative stress biomarkers (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [TAC]).  We searched the PubMed, Embase, and Cochrane Library databases for articles published before June 26, 2023. The literature search combined free words and the medical subject headings terms related to acne vulgaris, SOD, MDA, and TAC. Data were analyzed using Stata 15 software. Additionally, we con ducted a subgroup analysis stratified by the severity of acne vulgaris. A total of 14 trials involving 1191 participa...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Herpes zoster infection in pregnancy: features and consequences
AbstractHerpes (varicella) zoster (HZ) infection occurs in 4 people per 1000 in the general US population (irrespective of prior varicella infection and vaccination status) each year and has been the subject of scientific inquiry for decades. The consequences of infection are myriad and may depend on the dermatome of involvement as well as host factors such as age, comorbidities, prior treatment or immunization, and immunologic status. Pregnancy is associated with an altered immune and hormonal status in the mother. While maternal HZ infection during pregnancy is not uncommon, the implications for both mother and child are...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Topical steroids or emollients: does order matter?
AbstractTopical corticosteroids, topical steroid-sparing agents, and emollients are all used to treat atopic dermatitis. However, there are no formal guidelines dictating the order and timing in which these topical modalities should be applied. Additionally, the order of application may change drug absorption, efficacy, and distribution. This is especially important for patients with atopic dermatitis. These patients have a dysfunctional skin barrier, which can lead to greater systemic absorption of drugs. Moreover, children already have an increased rate of systemic absorption due to a higher ratio of body surface area to...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis
AbstractNo randomized trials exist to inform the peripheral surgical margins or depth of wide excision for eyelid melanoma. We performed a meta-analysis examining surgical margins and Breslow depth for eyelid melanomas. A systematic review was performed in August 2022 using PubMed, Cochrane, and Medline databases (1/1/1990 to 8/1/2022). Inclusion criteria included studies reporting surgical treatment of primary cutaneous melanomas of the eyelid with reported surgical margins. Ten articles were included. The studies were examined by surgical margin size (group 1:  ≤ 0.5 cm; group 2 >  0.5 cm and ≤ 1.5 ...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

Circulating biomarkers of oxidative stress in people with acne vulgaris: a systematic review and meta-analysis
This study aimed to explore the potential correlation between acne vulgaris and circulating oxidative stress biomarkers (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [TAC]).  We searched the PubMed, Embase, and Cochrane Library databases for articles published before June 26, 2023. The literature search combined free words and the medical subject headings terms related to acne vulgaris, SOD, MDA, and TAC. Data were analyzed using Stata 15 software. Additionally, we con ducted a subgroup analysis stratified by the severity of acne vulgaris. A total of 14 trials involving 1191 participa...
Source: Archives of Dermatological Research - March 15, 2024 Category: Dermatology Source Type: research

The United States dermatology inpatient workforce between 2013 and 2019: a Medicare analysis reveals contraction of the workforce and vast access deserts —a cross-sectional analysis
In conclusion, the number of dermatologists performing>  10 inpatient encounters per year is decreasing, and large variations exist in the number of U.S. inpatient dermatology visits. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 14, 2024 Category: Dermatology Source Type: research

Cracking the code: unveiling the nexus between atopic dermatitis and addictive behavior: a cross-sectional exploration of risk factors
AbstractAtopic dermatitis (AD) stands as a prevalent chronic inflammatory skin disorder with a global reach. Beyond its cutaneous manifestations, AD is accompanied by comorbidities and psychological issues, significantly compromising the overall quality of life for individuals who suffer from AD. Previous research has evidenced a heightened prevalence of addictive disorders among dermatological patients when compared to the general population. Considering these findings, this study endeavors to examine the prevalence of addictive disorders among AD patients and, furthermore, to discern potential risk factors associated wit...
Source: Archives of Dermatological Research - March 14, 2024 Category: Dermatology Source Type: research

The United States dermatology inpatient workforce between 2013 and 2019: a Medicare analysis reveals contraction of the workforce and vast access deserts —a cross-sectional analysis
In conclusion, the number of dermatologists performing>  10 inpatient encounters per year is decreasing, and large variations exist in the number of U.S. inpatient dermatology visits. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - March 14, 2024 Category: Dermatology Source Type: research