Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.
CONCLUSION: According to the described effects on EOC biology, all three Wnt manipulators seem to have the potential to augment the impact of a platinum-based chemotherapy in EOC. This is promising as a dominance of this pathway was confirmed in serous histology. PMID: 32681294 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - September 17, 2020 Category: Research Authors: Kaltofen T, Preinfalk V, Schwertler S, Fraungruber P, Heidegger H, Vilsmaier T, Vattai A, Czogalla B, Mayr D, Mahner S, Jeschke U, Trillsch F Tags: J Cancer Res Clin Oncol Source Type: research

Implications of flavonoids as potential modulators of cancer neovascularity.
CONCLUSION: Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest. PMID: 32902794 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 9, 2020 Category: Research Authors: Liskova A, Koklesova L, Samec M, Varghese E, Abotaleb M, Samuel SM, Smejkal K, Biringer K, Petras M, Blahutova D, Bugos O, Pec M, Adamkov M, Büsselberg D, Ciccocioppo R, Adamek M, Rodrigo L, Caprnda M, Kruzliak P, Kubatka P Tags: J Cancer Res Clin Oncol Source Type: research

Distribution of the HTT gene A1 and A2 haplotypes worldwide: A systematic review.
CONCLUSION: Regardless of the size of the CAG tract, the articles included in this review demonstrate that populations with high HD prevalence present higher frequencies of the A1 or A2 haplotypes than populations exhibiting low HD prevalence, even when similar average CAG numbers are noted. Based on the presented articles, we suggest that the haplotypic profile is more closely related to the ancestral origin than to the size of the CAG tract. The identification of populations presenting a higher frequency of high-risk genotypes can contribute to more accurate genetic counseling, in addition to providing knowledge on HD ep...
Source: Clin Med Res - September 2, 2020 Category: Research Authors: Apolinário TA, Rodrigues DC, Lemos MB, Paiva CLA, Agostinho LA Tags: Clin Med Res Source Type: research

Repeat Pregnancy after Prior Aortic Valve-in-Valve Replacement: Cautionary Tale.
We describe the first result of a repeat pregnancy outcome in a woman with a history of prior TAVR in SAVR. Both maternal and fetal outcomes were favorable, but maternal cardiac complications observed in the third trimester emphasize our concerns regarding risk for cardiac complications in subsequent pregnancies in patients with a prior TAVR in SAVR. Despite the maternal complications that occurred during repeat pregnancy in this patient, a successful pregnancy outcome reaffirms our recommendation to utilize a multidisciplinary team for pregnancy management in patients with prior TAVR or TAVR in SAVR and to help in the man...
Source: Clin Med Res - September 2, 2020 Category: Research Authors: Rasmussen K, Rokey R, Rolak SC, Zhong C, Braxton JH, Hashimoto K Tags: Clin Med Res Source Type: research

Response rate and safety in patients with hepatocellular carcinoma treated with transarterial chemoembolization using 40- µm doxorubicin-eluting microspheres.
CONCLUSION: Superselective DEB-TACE with 40-µm sized Embozene Tandem™ can be considered an effective and safe treatment, given the number of procedure-related complications. PMID: 32880029 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 2, 2020 Category: Research Authors: Albrecht KC, Aschenbach R, Diamantis I, Eckardt N, Teichgräber U Tags: J Cancer Res Clin Oncol Source Type: research

Mechanical revision following pedicle subtraction osteotomy: a competing risk survival analysis in 171 consecutive adult spinal deformity patients.
CONCLUSIONS: In a consecutive single-center cohort of patients undergoing PSO for ASD, we found an estimated incidence of revision surgery due to mechanical failure of 34% 2 years postoperatively. Fusion to the sacrum and preoperative PT > 20° were associated with elevated risks of revision. LEVEL OF EVIDENCE: Prognostic III. PMID: 32875546 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 1, 2020 Category: Research Authors: Bari TJ, Hallager DW, Hansen LV, Dahl B, Gehrchen M Tags: Spine Deform Source Type: research

Gastrointestinal Bleeding as a Complication in Continuous Flow Ventricular Assist Devices: A Systematic Review With Meta-Analysis.
Conclusions: The result obtained from this research indicates that the occurrence of gastrointestinal bleeding is not significantly different in both groups of patients, irrespective of the type of continuous flow VAD used. Although, the study sample used in this meta-analysis was limited. PMID: 32849943 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Asuka E, Pak S, Thiess AK, Torres A Tags: J Clin Med Res Source Type: research

The Clinical Benefit of Adjuvant Therapy in Long-Term Survival of Early-Stage Ampullary Carcinoma: A Single Institutional Experience.
Conclusions: In the early-stage AC, adjuvant therapy may not improve the outcome in the short term but may benefit over a long period. It should be considered, especially in patients with adverse risk factors. Radiation therapy may not be useful in managing AC in the adjuvant setting. PMID: 32849944 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Manne A, Hatic H, Li P, Jacob R, Williams G, Paluri R Tags: J Clin Med Res Source Type: research

Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition.
Conclusions: Individuals with CP, but not healthy individuals or those after clinical resolution of AP, are characterized by elevated circulating levels of periostin that are positively associated with intra-pancreatic fat deposition. PMID: 32849945 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Ko J, Stuart CE, Modesto AE, Cho J, Bharmal SH, Petrov MS Tags: J Clin Med Res Source Type: research

Validity of Serum miRNA 93 and miRNA 191 to Reduce Unnecessary Computed Tomography in Patients With Mild Head Trauma.
Conclusions: Circulating miRNA levels increased after MHT and differentiated patients with and without intracranial or extracranial lesions demonstrable on CCT. Adding the measurement of serum miRNAs particularly miR191 to the clinical decision rules for a CCT scan in patients with MHI could allow a reduction in scans. PMID: 32849946 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Tas D, Kaplan O, Sogut O Tags: J Clin Med Res Source Type: research

A Controllable Inflammatory Response and Temporary Abnormal Coagulation in Moderate Disease of COVID-19 in Wuhan, China.
Conclusions: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a controllable inflammatory response in moderate disease of COVID-19 in Wuhan, China. Since patients older than 60 years had higher inflammatory state and more dysregulated coagulation condition, it might be essential to closely assess their illness. PMID: 32849947 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Liu Y, Zhang X, Qiao J, Gong R, You Q, Sun J, Liu W, Sun B Tags: J Clin Med Res Source Type: research

Association Between Serum Apolipoprotein A1 Levels, Ischemic Stroke Subtypes and Plaque Properties of the Carotid Artery.
Conclusions: These findings suggest that serum ApoA1 levels might be associated with the development of ATBI and plaque properties of the carotid artery. PMID: 32849948 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Ohtani R, Nirengi S, Sakane N Tags: J Clin Med Res Source Type: research

Effects of Short-Term Hydroxychloroquine Plus Moxifloxacin Therapy on Corrected QT Interval and Tp-e Interval in Patients With COVID-19.
Conclusions: HCQ + MOX combination therapy led to increases in QTc interval, Tp-e interval, and cTp-e interval. However, this therapy did not cause ventricular arrhythmia in the short-term observation. PMID: 32849949 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Afsin A, Ecemis K, Asoglu R Tags: J Clin Med Res Source Type: research

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus.
Conclusions: The serum irisin level in T2DM group was significantly lower than that in control group, suggesting that irisin may be a protective factor for type 2 diabetes. PMID: 32849950 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Xuan X, Lin J, Zhang Y, Zhou L, Xu L, Jia J, Zhao B, Lin Z, Zhu Q, Li L, Wu T, Zhang S, Jiang H, Wang Y Tags: J Clin Med Res Source Type: research

Trace Proteinuria and the Incidence of Overt Proteinuria After Five Years: Results of the Kanagawa Investigation of the Total Checkup Data From the National Database-5 (KITCHEN-5).
Conclusions: Our findings suggest that TrP, particularly R-TrP, is substantially associated with the future incidence of OP, which may be independent of confounding factors and the methods detecting TrP. PMID: 32849951 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Nakajima K, Higuchi R, Mizusawa K Tags: J Clin Med Res Source Type: research

An Atypical Presentation of COVID-19 in a Previously Healthy Young Male With a Rare Cause of Abdominal Pain.
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by a newly discovered coronavirus that has reached pandemic proportions impacting millions globally. Authors feature an atypical case of COVID-19 presenting with a rare cause of abdominal pain and severe hyperglycemia. A 22-year-old male presented to the hospital with a 1-day history of severe abdominal pain. An abdominal computed tomography (CT) scan revealed findings of epiploic appendagitis (EA) and incidentally noted suspicious pulmonary lesions suggestive of COVID-19. Radiographic findings and distinctive laboratory results ...
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Bashari DR, Peguero-Tejada JL, Shah JI Tags: J Clin Med Res Source Type: research

Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide.
This study aimed to further evaluate the prognostic role of age in a homogenously treated patient cohort. METHODS: The study includes 132 IDH-wildtype glioblastoma patients treated between 2013 and 2017 with open resection followed by radiotherapy with concomitant and maintenance temozolomide. Patients were dichotomized into a non-elderly (
Source: Clin Med Res - August 3, 2020 Category: Research Authors: Berger K, Turowski B, Felsberg J, Malzkorn B, Reifenberger G, Steiger HJ, Budach W, Haussmann J, Knipps J, Rapp M, Hänggi D, Sabel M, Mijderwijk HJ, Kamp MA Tags: J Cancer Res Clin Oncol Source Type: research

Effect of renal denervation in attenuating the stress of morning surge in blood pressure: post-hoc analysis from the SPYRAL HTN-ON MED trial.
CONCLUSIONS: This decrease in the morning DBP surge slope, an index of the sympathetically-mediated morning BP surge, thus indicates a drop in late morning BP relative to early morning/nocturnal BP in the RDN group. Thus, RDN appears effective in attenuating the slope of morning surge in DBP that might indicate possible benefits in a high-risk hypertensive population. CLINICAL TRIAL REGISTRATION: https://www.clinicaltrials.gov (NCT02439775), registered May 12, 2015. PMID: 32740754 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 1, 2020 Category: Research Authors: Kario K, Weber MA, Böhm M, Townsend RR, Mahfoud F, Schmieder RE, Tsioufis K, Cohen SA, Fahy M, Kandzari DE Tags: Clin Res Cardiol Source Type: research

Current treatment options in RAS mutant metastatic colorectal cancer patients: a meta-analysis of 14 randomized phase III trials.
CONCLUSION: The therapeutic benefit of additional substances is less distinct in patients with RAS mutated as compared to RAS wildtype metastatic colorectal cancer, especially with regard to OS. PMID: 32561975 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - July 15, 2020 Category: Research Authors: Stahler A, Heinemann V, Ricard I, von Einem JC, Giessen-Jung C, Westphalen CB, Michl M, Heinrich K, Miller-Phillips L, Jelas I, Stintzing S, Modest DP Tags: J Cancer Res Clin Oncol Source Type: research

Collateral damage of COVID-19-lockdown in Germany:  decline of NSTE-ACS admissions.
Collateral damage of COVID-19-lockdown in Germany: decline of NSTE-ACS admissions. Clin Res Cardiol. 2020 Jul 10;: Authors: Gitt AK, Karcher AK, Zahn R, Zeymer U PMID: 32651656 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 10, 2020 Category: Research Authors: Gitt AK, Karcher AK, Zahn R, Zeymer U Tags: Clin Res Cardiol Source Type: research

Comments on 'Recurrent sigmoid volvulus in a patient with Parkinson's disease': authors' response.
PMID: 32638181 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 7, 2020 Category: Research Authors: Sakakibara R Tags: Clin Auton Res Source Type: research

Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota.
Abstract The present study investigated whether or not the oral administration of trehangelin-A (THG-A) is effective for metabolic disorders caused by a high-fat diet, as we previously showed that the intraperitoneal administration of THG-A improved metabolic disorders caused by a high-fat diet. Mice received a control diet or high-fat diet for eight weeks. Concurrently, mice were orally administered 0.2 ml/mouse phosphate-buffered saline (PBS) or 1 or 10 mg/0.2 ml/mouse of THG-A once daily during the experiment. The weight gain caused by a high-fat diet was significantly suppressed by oral THG-A compared to a hig...
Source: Clin Med Res - July 1, 2020 Category: Research Authors: Ishikawa H, Ino S, Nakashima T, Matsuo H, Takahashi Y, Kohda C, Ōmura S, Iyoda M, Tanaka K Tags: Obes Res Clin Pract Source Type: research

Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection.
CONCLUSION: Impaired cardiac function is associated with poor prognosis in COVID-19 positive patients. Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic. PMID: 32537662 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 14, 2020 Category: Research Authors: Rath D, Petersen-Uribe Á, Avdiu A, Witzel K, Jaeger P, Zdanyte M, Heinzmann D, Tavlaki E, Müller K, Gawaz MP Tags: Clin Res Cardiol Source Type: research

Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients.
CONCLUSION: Depending on nuclear or cytoplasmic expression, our study shows that THRα and its isoforms 1 and 2 provide different prognostic information for ovarian cancer patients. Further investigations should analyze if THRs may represent new endocrine targets for the treatment of ovarian cancer. PMID: 32533406 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 12, 2020 Category: Research Authors: Ditsch N, Heublein S, Jeschke U, Sattler C, Kuhn C, Hester A, Czogalla B, Trillsch F, Mahner S, Engel J, Mayr D, Schmoeckel E Tags: J Cancer Res Clin Oncol Source Type: research

Retrospective observation of children with the diagnosis of postural tachycardia syndrome while on atomoxetine.
PMID: 32514797 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 8, 2020 Category: Research Authors: Go S, Takahashi R, Suzuki S, Kasuga A, Morichi S, Ishida Y, Yamanaka G, Kashiwagi Y, Kawashima H Tags: Clin Auton Res Source Type: research

Response to the letter to the editor by Nagai M et al. entitled "Right insular cortex atrophy in Takotsubo syndrome: a possible pathogenesis of increased sympathetic nervous system activity?"
Response to the letter to the editor by Nagai M et al. entitled "Right insular cortex atrophy in Takotsubo syndrome: a possible pathogenesis of increased sympathetic nervous system activity?" Clin Res Cardiol. 2020 Jun 03;: Authors: Barbieri F, Tuovinen N, Steiger R, Dichtl W PMID: 32494922 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 3, 2020 Category: Research Authors: Barbieri F, Tuovinen N, Steiger R, Dichtl W Tags: Clin Res Cardiol Source Type: research

Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus.
CONCLUSIONS: We obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy. PMID: 32502691 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 2, 2020 Category: Research Authors: Sawada S, Tsuchiya S, Kodama S, Kurosawa S, Endo A, Sugawara H, Hosaka S, Kawana Y, Asai Y, Yamamoto J, Munakata Y, Izumi T, Takahashi K, Kaneko K, Imai J, Ito A, Yasuda M, Kunikata H, Nakazawa T, Katagiri H Tags: Diabetes Res Clin Pract Source Type: research

The diagnostic benefit of 16S rDNA PCR examination of infective endocarditis heart valves: a cohort study of 146 surgical cases confirmed by histopathology.
CONCLUSION: Valve PCR was found to be a valuable diagnostic tool in surgical endocarditis cases with negative blood cultures or positive blood cultures of unknown significance. TRIAL REGISTRATION: S-440/2017 on 28.08.2017 retrospectively registered. Subdividing of all infective endocarditis patients in this study, showing that valve PCR yields valuable information for patients with skin commensals in blood cultures, which were either confirmed by the same detection in valve PCR or refuted by the detection of a different and typical pathogen in valve PCR. Additionally, benefit was determined in patients with negative o...
Source: Clin Med Res - June 2, 2020 Category: Research Authors: Armstrong C, Kuhn TC, Dufner M, Ehlermann P, Zimmermann S, Lichtenstern C, Soethoff J, Katus HA, Leuschner F, Heininger A Tags: Clin Res Cardiol Source Type: research

Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).
CONCLUSION: These results indicated that EP3 signaling pathway might facilitate the migration of cervical cancer cells through modulating uPAR expression. Therefore, EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages. PMID: 32488496 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 1, 2020 Category: Research Authors: Ye Y, Peng L, Vattai A, Deuster E, Kuhn C, Dannecker C, Mahner S, Jeschke U, von Schönfeldt V, Heidegger HH Tags: J Cancer Res Clin Oncol Source Type: research

Alzheimer's Disease Therapeutic Approaches.
Abstract Alzheimer's disease (AD) was first described and diagnosed by Dr. Alois Alzheimer in 1906 (Hippius and Neundorfer, Dialogues Clin Neurosc 5:101-108, 2003). According to World Health Organization (WHO), AD is the most common cause of dementia, accounting for as many as 60-70% of senile dementia cases and affecting 47.5 million people worldwide (data from 2015) (Dementia Fact Sheet No 362. http://who.int/mediacentre/factsheets/fs362/en/ ). The median survival time after the onset of dementia ranges from 3.3 to 11.7 years (Todd et al. Int J Geriatr Psychiatry 28:1109-1124, 2013). AD is characterized as ...
Source: Clin Med Res - May 30, 2020 Category: Research Authors: Revi M Tags: Adv Exp Med Biol Source Type: research

Expression of H3K4me3 and H3K9ac in breast cancer.
CONCLUSION: This analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies. PMID: 32468423 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 28, 2020 Category: Research Authors: Berger L, Kolben T, Meister S, Kolben TM, Schmoeckel E, Mayr D, Mahner S, Jeschke U, Ditsch N, Beyer S Tags: J Cancer Res Clin Oncol Source Type: research

Impact of the introduction of percutaneous edge-to-edge mitral valve reconstruction on clinical practice in Germany compared to surgical valve repair.
, Stachon P Abstract BACKGROUND: The introduction of percutaneous mitral valve (MV) repair had an effect on clinical practice in comparison with surgical MV repair. Complete nationwide data are useful in examining how the introduction of a new technique influences clinical practice. METHODS: We analyzed procedural numbers, patient characteristics, and in-hospital outcomes for all percutaneous edge-to-edge and surgical MV reconstruction procedures performed in Germany between 2009 and 2015. RESULTS: 12,664 percutaneous edge-to-edge and 22,825 surgical MV reconstructions were recorded. Numbers increased st...
Source: Clin Med Res - May 27, 2020 Category: Research Authors: Frankenstein L, Kaier K, Katus HA, Bode C, Wengenmayer T, von Zur Mühlen C, Bekeredjian R, Täger T, Zehender M, Fröhlich H, Stachon P Tags: Clin Res Cardiol Source Type: research

The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients.
CONCLUSION: The novel association of the disease state with tumoral and paratumoral immune cell signatures suggests new possibilities for personalized immunotherapy for EC patients. PMID: 32447483 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 23, 2020 Category: Research Authors: Strizova Z, Snajdauf M, Stakheev D, Taborska P, Vachtenheim J, Biskup J, Lischke R, Bartunkova J, Smrz D Tags: J Cancer Res Clin Oncol Source Type: research

A 63-year-old female patient with fever, myalgias and interstitial lung disease.
PMID: 32436054 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 20, 2020 Category: Research Authors: Hellwege RS, Henes J, Greulich S, Gawaz M Tags: Clin Res Cardiol Source Type: research

Cardiovascular autonomic function testing in multiple system atrophy and Parkinson's disease: an expert-based blinded evaluation.
CONCLUSION: CAFT is the gold standard for assessing the presence and severity of cardiovascular autonomic failure, but the results of our pilot study suggest that CAFT might be of limited value in the differential diagnosis between MSA-P and PD once nOH is present. PMID: 32415621 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 15, 2020 Category: Research Authors: Leys F, Fanciulli A, Ndayisaba JP, Granata R, Struhal W, Wenning GK Tags: Clin Auton Res Source Type: research

Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
CONCLUSIONS: No cases in Groups A and B expressed PD-L1. The expression of immune-related factors, especially PD-L1 and IDO1, was significantly associated with Group C. This is the first report of the detailed examination of PD-L1, PD-L2, IDO1, and CD8 expression in lung adenocarcinoma subtypes with lepidic predominant components. Our results could help identify patients who would benefit from perioperative immunotherapy. PMID: 32405745 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 14, 2020 Category: Research Authors: Takada K, Toyokawa G, Kinoshita F, Jogo T, Kohashi K, Wakasu S, Ono Y, Tanaka K, Oba T, Osoegawa A, Tagawa T, Azuma K, Okamoto I, Shimokawa M, Oda Y, Mori M Tags: J Cancer Res Clin Oncol Source Type: research

Recommendations on complementary and alternative medicine within S3 guidelines in oncology: systematic quality assessment of underlying methodology.
CONCLUSIONS: Concerning CAM statements and recommendations within S3 guidelines quality of evidence processing has several shortcomings. Guideline adaptions often lack transparency and traceability. PMID: 32394053 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 11, 2020 Category: Research Authors: Kutschan S, Freuding M, Keinki C, Huebner J Tags: J Cancer Res Clin Oncol Source Type: research

PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients: comparative study of primary and metastatic lesions.
CONCLUSION: Our results suggest that the PD-L1 and IDO1 immune checkpoint inhibitors may provide clinical benefit in osteosarcoma patients with metastatic lesions after conventional chemotherapy. PMID: 32388585 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 9, 2020 Category: Research Authors: Toda Y, Kohashi K, Yamada Y, Yoshimoto M, Ishihara S, Ito Y, Iwasaki T, Yamamoto H, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y Tags: J Cancer Res Clin Oncol Source Type: research

Concurrent definitive immunoradiotherapy for patients with Stage III-IV Head and Neck Cancer and Cisplatin contraindication.
CONCLUSIONS: Pembrolizumab and radiotherapy is efficacious in LA-HNSCC and should be evaluated in a randomized trial. The observed changes in B-cell markers deserve further study both as potential biomarkers and as therapeutic targets. PMID: 32371539 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 5, 2020 Category: Research Authors: Weiss J, Sheth S, Deal AM, Grilley Olson JE, Patel S, Hackman TG, Blumberg JM, Galloway T, Patel S, Zanation AM, Shen CJ, Hayes DN, Hilliard C, Mehra R, McKinnon KP, Wang HH, Weissler MC, Bauman JR, Chera BS, Vincent BG Tags: Clin Cancer Res Source Type: research

Admission Hyperglycemia and Radiological findings of SARS-COv2 in patients with and without Diabetes.
Abstract Diabetes emerged as major risk factor for severe acute respiratory syndrome (SARS) and adverse outcome in patients with the coronavirus disease 2019 (COVID-19). Nevertheless, the role of admission hyperglycemia in patients with COVID-19 has not been well-explored, yet. With this retrospective analysis, we report for the first time that hyperglycemia on day-1 is the best predictor of radiographic imaging of SARS-Cov2, regardless of the past medical history of diabetes. Admission hyperglycemia should not be overlooked, but adequately treated to improve the outcomes of COVID-19 patients with our without diab...
Source: Clin Med Res - April 30, 2020 Category: Research Authors: Iacobellis G, Penaherrera CA, Bermudez LE, Bernal Mizrachi E Tags: Diabetes Res Clin Pract Source Type: research

Impact of successful local ablative bridging therapy prior to liver transplantation on long-term survival in patients with hepatocellular carcinoma in cirrhosis.
CONCLUSIONS: Successful local ablative therapy before liver transplantation is an independent statistically significant factor in long-term tumor-related survival for patients with HCC in cirrhosis and reduces tumor recurrences. PMID: 32356179 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 30, 2020 Category: Research Authors: Bauschke A, Altendorf-Hofmann A, Ardelt M, Kissler H, Tautenhahn HM, Settmacher U Tags: J Cancer Res Clin Oncol Source Type: research

Diabetes mellitus exacerbates citrin deficiency via glucose toxicity.
CONCLUSION: Glucose is not toxic for citrin deficiency in normoglycemia because glucose uptake and metabolism by hepatocytes are limited in normoglycemia. However, glucose becomes toxic during persistent hyperglycemia and antidiabetic therapy is indispensable for CTLN2 patients with DM. PMID: 32335094 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 23, 2020 Category: Research Authors: Watanabe Y, Numakura C, Tahara T, Fukui K, Torimura T, Hiromatsu Y, Tomotsune K, Yamakawa M, Hayasaka K Tags: Diabetes Res Clin Pract Source Type: research

Microtubule engagement with taxane is altered in taxane-resistant gastric cancer.
CONCLUSION: our data reveal that taxane-resistance is more prevalent in patients with DIF-GC, support assessment of drug-target engagement as a early read-out of taxane clinical efficacy, and encourage the investigation of kinesins and other microtubule-associated proteins as potentially targetable mediators of taxane resistance in GC. PMID: 32321717 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 22, 2020 Category: Research Authors: Galletti G, Zhang C, Gjyrezi A, Cleveland K, Zhang J, Powell S, Thakkar PV, Betel D, Shah MA, Giannakakou P Tags: Clin Cancer Res Source Type: research

Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry.
CONCLUSIONS: In this registry, approximately 85% of LAA thrombi were diagnosed in patients with ongoing OAC. Thrombus resolution was observed in nearly 50% of cases. Although there was no difference in the rate of LAA thrombus resolution between VKA and NOACs, the resolution time was shorter in patients prescribed a NOAC. PMID: 32307589 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 19, 2020 Category: Research Authors: Nelles D, Lambers M, Schafigh M, Morais P, Schueler R, Vij V, Tiyerili V, Weber M, Schrickel JW, Nickenig G, Hammerstingl C, Sedaghat A Tags: Clin Res Cardiol Source Type: research

A method of using deep learning to predict three-dimensional dose distributions for intensity-modulated radiotherapy of rectal cancer.
CONCLUSIONS: This study developed a more general deep learning model by considering beam configurations input and achieved an accurate 3D voxel-wise dose prediction for rectal cancer treated by IMRT, a potentially easier clinical implementation for more comprehensive automatic planning. PMID: 32281254 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 13, 2020 Category: Research Authors: Zhou J, Peng Z, Song Y, Chang Y, Pei X, Sheng L, Xu XG Tags: J Appl Clin Med Phys Source Type: research

Impact of neoadjuvant durvalumab with or without tremelimumab on CD8+ tumor lymphocyte density, safety, and efficacy in patients with oropharynx cancer: CIAO trial.
CONCLUSIONS: Durvalumab plus tremelimumab did not increase CD8+TIL density more than durvalumab alone did. The observed safety and activity support further investigation of neoadjuvant checkpoint inhibitor for OPC. PMID: 32269052 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2020 Category: Research Authors: Ferrarotto R, Bell D, Rubin ML, Hutcheson KA, Johnson JM, Goepfert RP, Phan J, Elamin YY, Torman Karagiannis DT, Warneke CL, Hessel AC, Garden AS, Myers JN, Johnson FM, Lee JJ, Sikora A, Gillison ML, Glisson BS, Gross ND Tags: Clin Cancer Res Source Type: research

Correction to: Rationale and design of two randomized sham ‑controlled of catheter‑based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN‑OFF MED Pivotal) and presence (SPYRAL HTN‑ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design.
Correction to: Rationale and design of two randomized sham‑controlled of catheter‑based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN‑OFF MED Pivotal) and presence (SPYRAL HTN‑ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design. Clin Res Cardiol. 2020 Apr 08;: Authors: Böhm M, Townsend RR, Kario K, Kandzari D, Mahfoud F, Weber MA, Schmieder RE, Tsioufis K, Hickey GL, Fahy M, DeBruin V, Brar S, Pocock S Abstract The original version of this article unfortunately contained a mistake. PMID: 32270345 [PubMed ...
Source: Clin Med Res - April 8, 2020 Category: Research Authors: Böhm M, Townsend RR, Kario K, Kandzari D, Mahfoud F, Weber MA, Schmieder RE, Tsioufis K, Hickey GL, Fahy M, DeBruin V, Brar S, Pocock S Tags: Clin Res Cardiol Source Type: research

Changes in mortality rates and ratios in people with pharmacologically treated type 2 diabetes mellitus between 2001 and 2016 in Hungary.
In this study we analyzed the changes of age- and gender-specific all-cause mortality rates and ratios in T2DM subjects (aged>40 years) in Hungary between 2001 and 2016. METHODS: We used the central database of the National Institute of Health Insurance Fund. All-cause mortality rates in patients with T2DM and ratios (T2DM/non-T2DM) were determined in males/females and in different age-groups. Age-adjusted values were used for standardized mortality rates. RESULTS: Among pharmacologically treated T2DM subjects we found 117,700 and 329,845 males, 232,143 and 391,382 females in 2001 and 2016, respectively. Stand...
Source: Clin Med Res - April 6, 2020 Category: Research Authors: Jermendy G, Kiss Z, Rokszin G, Fábián I, Wittmann I, Kempler P Tags: Diabetes Res Clin Pract Source Type: research

Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama Study.
This study aimed to examine correlates of ANS function with special reference to HbA1c which is more stable than plasma glucose among community residents. METHODS: Spectral analysis was performed to assess heart rate variability (HRV) using 1-minute electrocardiogram RR interval data recordings from 7690 residents aged 35-79 years in Nagahama City, Japan. HRV parameters were log-transformed. Multiple regression analysis was performed using potential correlates. RESULTS: lnLF decreased with age (regression coefficient, -0.025; P
Source: Clin Med Res - March 31, 2020 Category: Research Authors: Takahashi N, Takahashi Y, Tabara Y, Matsumoto T, Kawaguchi T, Kuriyama A, Ueshima K, Matsuda F, Chin K, Nakayama T, Nagahama Study Group Tags: Diabetes Res Clin Pract Source Type: research

COVID-19 and Diabetes: can DPP4 inhibition play a role?
PMID: 32224164 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - March 26, 2020 Category: Research Authors: Iacobellis G Tags: Diabetes Res Clin Pract Source Type: research