Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study.
CONCLUSION: These findings strengthen our understanding of the detrimental effect of solvent exposure on cognitive health not only in men but also in women for the first time, in a large general population middle-aged and early-ageing sample from France, taking into account working conditions. PMID: 32075885 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 19, 2020 Category: Research Authors: Letellier N, Choron G, Artaud F, Descatha A, Goldberg M, Zins M, Elbaz A, Berr C Tags: Occup Environ Med Source Type: research

New advances in antiangiogenic combination therapeutic strategies for advanced non-small cell lung cancer.
CONCLUSIONS: Antiangiogenic agents can achieve therapeutic benefit in advanced NSCLC patients and the combination of chemotherapy, targeted therapy or immunotherapy can lead to synergistic effect. However, exploring the best combination therapy and efficacy-related biomarkers needs further study. PMID: 32065262 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 17, 2020 Category: Research Authors: Qiang H, Chang Q, Xu J, Qian J, Zhang Y, Lei Y, Han B, Chu T Tags: J Cancer Res Clin Oncol Source Type: research

Antiemetic prophylaxis with fosaprepitant and granisetron in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation.
g M Abstract BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing. METHODS: In this non-interventional observation study, 120 children and adolescents with a median age of 11.8 years undergoing alloHSCT after a moderately or highly emetogenic conditioning (MEC or HEC) were analyzed. They received ...
Source: Clin Med Res - February 13, 2020 Category: Research Authors: Cabanillas Stanchi KM, Vek J, Schlegel P, Rupprecht JV, Flaadt T, Weber S, Michaelis S, Lang P, Handgretinger R, Döring M Tags: J Cancer Res Clin Oncol Source Type: research

Long-term outcome upon treatment of calcified lesions of the lower limb using scoring angioplasty balloon (AngioSculpt ™).
CONCLUSION: Lesion preparation with AngioSculpt™ scoring balloon represents a safe and effective tool in the treatment of complex femoropopliteal lesions. In this retrospective analysis, AngioSculpt™ scoring balloon angioplasty did not significantly improve vessel patency- both when used as an adjunctive in preparation for stenting and as stand-alone treatment. A prospective study is needed to further investigate the scoring balloon treatment options. PMID: 32036430 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2020 Category: Research Authors: Kronlage M, Werner C, Dufner M, Blessing E, Müller OJ, Heilmeier B, Katus HA, Erbel C Tags: Clin Res Cardiol Source Type: research

Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design.
CONCLUSIONS: The Bayesian paradigm represents a novel and promising approach in device-based hypertension trials. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02439749 (SPYRAL HTN-OFF MED Pivotal) and NCT02439775 (SPYRAL HTN-ON MED Expansion). PMID: 32034481 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 7, 2020 Category: Research Authors: Böhm M, Townsend RR, Kario K, Kandzari D, Mahfoud F, Weber MA, Schmieder RE, Tsioufis K, Hickey GL, Fahy M, DeBruin V, Brar S, Pocock S Tags: Clin Res Cardiol Source Type: research

Pancreatic anti-GP2 and anti-Saccharomyces cerevisiae antibodies in ruminants with paratuberculosis: A better understanding of the immunopathogenesis of Crohn's disease.
CONCLUSION: ASCA are present in a significant proportion of ruminants with ptb and correlate with anti-GP2 antibody positivity, a finding further supporting the notion that Crohn's disease and ptb share common immunological mechanisms of antigen-driven loss of self-tolerance. PMID: 32035824 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 5, 2020 Category: Research Authors: Liaskos C, Gkoutzourelas A, Spyrou V, Koutsoumpas A, Athanasiou LV, Amiridis GS, Billinis C, Bogdanos DP Tags: Clin Res Hepatol Gastroenterol Source Type: research

Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors.
CONCLUSIONS: L3 muscle index Low is an independent predictor of worse outcomes in NSCLC patients treated with anti-PD-1 inhibitors. PMID: 32025867 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 5, 2020 Category: Research Authors: Takada K, Yoneshima Y, Tanaka K, Okamoto I, Shimokawa M, Wakasu S, Takamori S, Toyokawa G, Oba T, Osoegawa A, Tagawa T, Oda Y, Nakanishi Y, Mori M Tags: J Cancer Res Clin Oncol Source Type: research

PD-L1 expression and survival in p16-negative and -positive squamous  cell carcinomas of the vulva.
PD-L1 expression and survival in p16-negative and -positive squamous cell carcinomas of the vulva. J Cancer Res Clin Oncol. 2020 Feb 05;: Authors: Czogalla B, Pham D, Trillsch F, Rottmann M, Gallwas J, Burges A, Mahner S, Kirchner T, Jeschke U, Mayr D, Schmoeckel E Abstract AIM: Programmed death-ligand 1 (PD-L1) has become a widely used predictive biomarker for therapy with checkpoint inhibitors in a variety of cancers. Here, we studied the expression of PD-L1 in squamous cell carcinomas of the vulva (SCCV) with regard to HPV status via its surrogate marker p16. Additionally, the status of P...
Source: Clin Med Res - February 5, 2020 Category: Research Authors: Czogalla B, Pham D, Trillsch F, Rottmann M, Gallwas J, Burges A, Mahner S, Kirchner T, Jeschke U, Mayr D, Schmoeckel E Tags: J Cancer Res Clin Oncol Source Type: research

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex.
Abstract BACKGROUND: A brain-heart interaction has been proposed in Takotsubo syndrome (TTS). Structural changes in the limbic system and hypoconnectivity between certain brain areas in the chronic phase of the disease have been reported, but little is known concerning functional neuroimaging in the acute phase. We hypothesizedh anatomical and functional changes in the central nervous system and investigated whole-brain volumetric and functional connectivity alterations in the acute phase TTS patients compared to controls. METHODS: Anatomical and resting-state functional magnetic resonance imaging were perfor...
Source: Clin Med Res - January 30, 2020 Category: Research Authors: Dichtl W, Tuovinen N, Barbieri F, Adukauskaite A, Senoner T, Rubatscher A, Hintringer F, Siedentopf C, Bauer A, Gizewski ER, Steiger R Tags: Clin Res Cardiol Source Type: research

Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source.
CONCLUSION: The results of this study are valuable addition to understanding the experience of patients with MM, despite several data limitations. PMID: 31970671 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 22, 2020 Category: Research Authors: Cenzer I, Berger K, Rodriguez AM, Ostermann H, Covinsky KE Tags: Aging Clin Exp Res Source Type: research

"Hedgehog pathway": a potential target of itraconazole in the treatment of cancer.
CONCLUSION: As a new anticancer drug, whether itraconazole eventually entering clinical application requires the joint eforts of all scholars. In any case, an in-depth study on itraconazole will bring new hope for cancer patients in the near future. PMID: 31960187 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 20, 2020 Category: Research Authors: Wei X, Liu W, Wang JQ, Tang Z Tags: J Cancer Res Clin Oncol Source Type: research

Research Letter: Trimethylamine N-oxide (TMAO) and ADP-induced platelet reactivity are independent risk factors for all-cause and cardiovascular mortality.
KA PMID: 31958034 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 20, 2020 Category: Research Authors: Berger M, Kleber ME, Delgado GE, März W, Hellstern P, Meinitzer A, Marx N, Schuett KA Tags: Circ Res Source Type: research

How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence.
CONCLUSION: Clinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis. PMID: 31955287 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 18, 2020 Category: Research Authors: Buentzel J, Bauer C, Buentzel J Tags: J Cancer Res Clin Oncol Source Type: research

The association of conventionally medicated systolic and diastolic blood pressure level and mortality from cardiovascular disease: is the lower the better in high stroke population?
PMID: 31950253 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 16, 2020 Category: Research Authors: Sakaniwa R, Tromp J, Shirai K, Yamagishi K, Tamakoshi A, Iso H Tags: Clin Res Cardiol Source Type: research

The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
CONCLUSIONS: Unlike other chronic liver diseases, carrying two MBOAT7 variant alleles does not seem to affect PSC patients negatively, but seems to have a positive effect on transplant-free survival. This study could help improve individual prognosis in PSC patients and give some new perspective on the involvement of the immune system in PSC. PMID: 31928970 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 9, 2020 Category: Research Authors: Freund C, Wahlers A, Begli NH, Leopold Y, Klöters-Plachky P, Mehrabi A, Mohr I, Sander J, Rupp C, Gotthardt DN, Weiss KH Tags: Clin Res Hepatol Gastroenterol Source Type: research

Inhibition of the mammalian target or rapamycin (mTOR): a potential therapeutic strategy for multiple system atrophy.
PMID: 31919620 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 9, 2020 Category: Research Authors: Ndayisaba A, Wenning GK Tags: Clin Auton Res Source Type: research

Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).
Abstract AIMS: Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM. METHODS: In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 s...
Source: Clin Med Res - January 2, 2020 Category: Research Authors: Fuse K, Kadota A, Kondo K, Morino K, Fujiyoshi A, Hisamatsu T, Kadowaki S, Miyazawa I, Ugi S, Maegawa H, Miura K, Ueshima H, SESSA Research Group Tags: Diabetes Res Clin Pract Source Type: research

Prostate specific membrane antigen (PSMA) in urothelial cell carcinoma (UCC) is associated with tumor grading and staging.
In this study we examine the expression of PSMA in urothelial cell carcinoma (UCC). METHODS: Immunhistochemical PSMA-staining was performed in 89 UCC samples. PSMA expression in tumor tissue, adjacent healthy tissue and blood vessels was examined. We furthermore analyzed PSMA-mRNA expression in nine human UCC cell lines. We correlated our findings with clinical data regarding recurrence and progression of UCC. RESULTS: UCC tissue showed a significantly higher PSMA expression compared to healthy urothelial tissue (p 
Source: Clin Med Res - January 2, 2020 Category: Research Authors: Schreiber H, Hänze J, Nimphius W, Verburg FA, Luster M, Hofmann R, Hegele A Tags: J Cancer Res Clin Oncol Source Type: research

Incidence of Radioembolization-Induced Liver Disease and Liver Toxicity Following Repeat 90Y-Radioembolization: Outcomes at a Large Tertiary Care Center.
CONCLUSIONS: Repeat Y-RE appears to be well tolerated with a low rate of high-grade adverse events and REILD. PMID: 31876805 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 23, 2019 Category: Research Authors: Elsayed M, Ermentrout RM, Sethi I, Bercu ZL, Galt JR, Whitmore M, Brandon DC, Schuster DM, Kokabi N Tags: Clin Nucl Med Source Type: research

Recurrent sigmoid volvulus in a patient with Parkinson's disease.
PMID: 31838591 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 14, 2019 Category: Research Authors: Tateno F, Sakakibara R, Aiba Y, Ogata T, Katsumata M, Matsuoka Y Tags: Clin Auton Res Source Type: research

Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects.
Abstract Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl peptidase (DPP) 4 inhibitors and glucose-dependent insulinotropic peptide (GLP-1) analogues increased the additional risk of different cancers to diabetic patients. Conversely, metformin has drawn attention among physicians and researchers since its use as antidiabetic drug exhibited beneficial effect in the prevention and treatment of cancer in diabetic patients as well as an independent anticancer...
Source: Clin Med Res - December 12, 2019 Category: Research Authors: Kamarudin MNA, Sarker MMR, Zhou JR, Parhar I Tags: J Exp Clin Cancer Res Source Type: research

Giant right coronary artery aneurysm - A rare presentation.
We report a case of a GCAA with an atypical presentation and describe its management. This will add to the current small database on CAA to provide clinicians a better insight on the disease. PMID: 31799794 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 4, 2019 Category: Research Authors: Kurnauth V, Morey M, Jarvis R Tags: J Med Imaging Radiat Oncol Source Type: research

Frailty impairs the feasibility of induction therapy but not of maintenance therapy in elderly myeloma patients: final results of the German Maintenance Study (GERMAIN).
CONCLUSION: A frailty assessment with appropriate dose modification for induction therapy should be mandatory for all elderly non-transplant-eligible myeloma patients. PMID: 31788741 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 2, 2019 Category: Research Authors: Brioli A, Manz K, Pfirrmann M, Hänel M, Schwarzer AC, Prange-Krex G, Fabisch C, Knop S, Illmer T, Krammer-Steiner B, Hochhaus A, von Lilienfeld-Toal M, Mügge LO Tags: J Cancer Res Clin Oncol Source Type: research

Symptomatic arrhythmias after catheter ablation of atrioventricular nodal reentrant tachycardia (AVNRT): results from the German Ablation Registry.
CONCLUSION: During long-term follow-up, one out of six patients experienced symptomatic arrhythmias after AVNRT ablation, associated with an increase of serious adverse events. A subset of patients required medical or interventional antiarrhythmic therapy, possibly attributable to the co-existence of other arrhythmias. Screening for arrhythmic and cardiac co-morbidity before and after ablation may support comprehensive therapy planning and outcome. PMID: 31784903 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 29, 2019 Category: Research Authors: Zylla MM, Brachmann J, Lewalter T, Kuck KH, Andresen D, Willems S, Spitzer SG, Straube F, Schumacher B, Eckardt L, Hochadel M, Senges J, Katus HA, Thomas D Tags: Clin Res Cardiol Source Type: research

Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma.
CONCLUSIONS: Our study, for the first time, demonstrates differential GR and AR expressions, autonomous GR and AR activation, and ligand-independent AR response in SDC cells. These findings provide critical information on the roles of GR and AR steroid receptors in SDC tumorigenesis and may lead to the development of a biomarker-based strategy to guide targeted steroid receptor therapy trials in patients with these tumors. PMID: 31772120 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 26, 2019 Category: Research Authors: Mitani Y, Lin SH, Pytynia KB, Ferrarotto R, El-Naggar AK Tags: Clin Cancer Res Source Type: research

Transcatheter aortic valve replacement acutely improves left ventricular mechanical efficiency in severe aortic stenosis: effects of different phenotypes.
Abstract AIM: Aortic stenosis is a frequent valvular disease, with transcatheter aortic valve implantation (TAVI) being performed when surgical replacement is at increased risk. However, TAVI-induced effects on myocardial efficiency are unknown. We aimed to investigate changes in LV mechano-energetic pre-/post-TAVI and their prognostic impact. METHODS: A total of 46 patients (25 males) received transesophageal and simultaneous radial pressure plus transaortic gradient monitoring before/immediately after prosthesis deployment. Efficiency was computed as external work/potential energy, as derived from LV pressu...
Source: Clin Med Res - November 20, 2019 Category: Research Authors: Marino PN, Binda G, Calzaducca E, Panizza A, Ferrari I, Bellacosa I, Ambrosio G Tags: Clin Res Cardiol Source Type: research

Metabolically healthy obesity (MHO) in the Malm ö diet cancer study - Epidemiology and prospective risks.
CONCLUSION: Compared to MUO individuals, MHO individuals presented with a higher level of physical activity, a more favorable lipid- and glucose profile and a lower prospective risk of total mortality and CV morbidity during 20-years follow-up. Notably, no significant differences could be seen in mortality and CV morbidity risks when comparing MHO subjects to non-obese controls. PMID: 31711772 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 8, 2019 Category: Research Authors: Korduner J, Bachus E, Jujic A, Magnusson M, Nilsson PM Tags: Obes Res Clin Pract Source Type: research

Changing trends in the prevalence of diabetic retinopathy in type 1 diabetes mellitus from 1990 to 2018: A retrospective study in a Portuguese population.
CONCLUSION: The prevalence of DR in our cohort was 34.8% after 15 years of systemic disease and 54.1% after 20 years, which is lower than what has been reported in the literature. Further multicentric prospective studies, are needed to clarify changes in the epidemiology of diabetic retinopathy in type 1 diabetics. PMID: 31669626 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - October 24, 2019 Category: Research Authors: Madeira C, Laiginhas R, Lopes M, Neves J, Rosas V, Barbosa M, Carvalho D, Falcão-Reis F, Falcão M Tags: Diabetes Res Clin Pract Source Type: research

Prolonged time to treatment initiation in advanced pancreatic cancer patients has no major effect on treatment outcome: a retrospective cohort study controlled for lead time bias and waiting time paradox.
CONCLUSION: While a timely work-up of advanced PC patients remains important, delays in treatment initiation due to repeated biopsies, inclusion in a clinical study or transfer to a specialized cancer center appear to be justified in light of the absence of a strong adverse effect of prolonged TTI on prognosis in advanced PC patients. PMID: 31642961 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - October 23, 2019 Category: Research Authors: Kruger S, Schirle K, Haas M, Crispin A, Schirra J, Mayerle J, D'Haese JG, Kunz WG, Ricke J, Ormanns S, Kirchner T, Kobold S, Ilmer M, Gebauer L, Westphalen CB, von Bergwelt-Baildon M, Werner J, Heinemann V, Boeck S Tags: J Cancer Res Clin Oncol Source Type: research

A novel risk score to predict survival in advanced heart failure due to cardiac amyloidosis.
CONCLUSIONS: Risk stratification for cardiac amyloidosis with the newly developed "HeiRisk" score may be superior to other staging systems for patients with advanced heart failure due to amyloid cardiomyopathy. PMID: 31630214 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - October 19, 2019 Category: Research Authors: Kreusser MM, Volz MJ, Knop B, Ehlermann P, Schmack B, Ruhparwar A, Hegenbart U, Schönland SO, Katus HA, Raake PW Tags: Clin Res Cardiol Source Type: research

The role of adipokines in the improvement of diabetic and cardiovascular risk factors within a 52-week weight-loss programme for obesity.
Abstract BACKGROUND: Obesity is an independent risk factor for cardiovascular disease and diabetes weight reduction not only reduces the risk for these diseases but leads to an alteration of the circulating adipokine levels. The aim of our study was to evaluate the effect of weight loss and lifestyle changes implemented in the form of the interdisciplinary weight management programme Optifast52® on cardiovascular and diabetic risk factors and on key adipokines. METHODS: 72 morbidly obese patients were included in the programme, which consisted of a very low-calorie diet followed by incremental food introd...
Source: Clin Med Res - October 4, 2019 Category: Research Authors: Hausmann J, Waechtershaeuser A, Behnken I, Aksan A, Blumenstein I, Brenner M, Loitsch SM, Stein J Tags: Obes Res Clin Pract Source Type: research

Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.
CONCLUSION: Our data indicates that eIF6 overexpression plays a major role in the translational control of GBC, and indicates its potential as a new biomarker and therapeutic target in GBC. PMID: 31586263 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - October 4, 2019 Category: Research Authors: Golob-Schwarzl N, Wodlej C, Kleinegger F, Gogg-Kamerer M, Birkl-Toeglhofer AM, Petzold J, Aigelsreiter A, Thalhammer M, Park YN, Haybaeck J Tags: J Cancer Res Clin Oncol Source Type: research

Serum haptoglobin levels are associated with renal function decline in type 2 diabetes mellitus patients in a Chinese Han population.
CONCLUSIONS: Our findings suggest that serum Hp levels may be used as a potential biomarker for the early diagnosis and monitoring of DKD in T2DM patients. PMID: 31545979 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 20, 2019 Category: Research Authors: Huang Y, Huang Y, Zhang R, Jin L, Zhang H, Hu C Tags: Diabetes Res Clin Pract Source Type: research

Molecular subtyping of gastric cancer with respect to the growth pattern of lymph-node metastases.
CONCLUSION: The present findings suggest that alterations in gastric cancer leading to ENE are not associated with alterations underpinning the molecular subgroups. Nonetheless, molecular subtyping on the basis of IHC and ISH is feasible and might become clinical routine. Thus, further studies are needed to clarify the mechanisms of extranodal extension in gastric cancer. PMID: 31541339 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 20, 2019 Category: Research Authors: Bösch F, Todorova R, Link H, Westphalen CB, Boeck S, Heinemann V, Werner J, Kirchner T, Angele MK, Neumann J Tags: J Cancer Res Clin Oncol Source Type: research

Inhibition of bone morphogenetic protein signaling reduces viability, growth and migratory potential of non-small cell lung carcinoma cells.
CONCLUSIONS: BMP signaling inhibition in LCLC-103H cells leads to reduced growth and proliferation, hindered migration and accelerated cell death. The findings contribute to the pool of evidence on BMP signaling in lung cancer with a possibility of introducing BMP signaling inhibition as a novel therapeutic approach for the disease. PMID: 31531741 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 17, 2019 Category: Research Authors: Mihajlović J, Diehl LAM, Hochhaus A, Clement JH Tags: J Cancer Res Clin Oncol Source Type: research

A Novel Ex Vivo System Using 3D Polymer Scaffold to Culture Circulating Tumor Cells from Breast Cancer Patients Exhibits Dynamic E-M Phenotypes.
Abstract The majority of the cancer-associated deaths is due to metastasis-the spread of tumors to other organs. Circulating tumor cells (CTCs), which are shed from the primary tumor into the circulation, serve as precursors of metastasis. CTCs have now gained much attention as a new prognostic and diagnostic marker, as well as a screening tool for patients with metastatic disease. However, very little is known about the biology of CTCs in cancer metastasis. An increased understanding of CTC biology, their heterogeneity, and interaction with other cells can help towards a better understanding of the metastatic pro...
Source: Clin Med Res - September 16, 2019 Category: Research Authors: De T, Goyal S, Balachander G, Chatterjee K, Kumar P, Babu K G, Rangarajan A Tags: J Clin Med Source Type: research

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.
CONCLUSIONS: While having only a small impact on basal PD-L1 expression, both wildtype and mutated p53 play an important positive role for IFN-ɣ-induced PD-L1 expression in melanoma cells by supporting JAK2 expression. Future studies should address, whether p53 expression levels might influence response to anti-PD-1 immunotherapy. PMID: 31506076 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - September 11, 2019 Category: Research Authors: Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt MV, Hermanns HM, Goebeler M, Meierjohann S, Houben R, Schrama D Tags: J Exp Clin Cancer Res Source Type: research

5-Azacytidine modulates CpG methylation levels of EZH2 and NOTCH1 in myelodysplastic syndromes.
CONCLUSIONS: A response to Aza is not associated with eradication of malignant clones, but rather with a stabilization of the clonal architecture. We suggest changes in CpG methylation levels of EZH2 and NOTCH1 as potential targets of epigenetic response to Aza treatment which may also serve as useful biomarkers after clinical evaluation. PMID: 31506740 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 10, 2019 Category: Research Authors: Gawlitza AL, Speith J, Rinke J, Sajzew R, Müller EK, Schäfer V, Hochhaus A, Ernst T Tags: J Cancer Res Clin Oncol Source Type: research

EP3 receptor is a prognostic factor in TA-MUC1-negative ovarian cancer.
r A Abstract PURPOSE: Prostaglandin-mediated inflammatory reactions play a major role in different cancers. Recently, it has been observed that prostaglandin E2-receptor 3 (EP3) might be an independent prognostic factor for overall survival in cervical and endometrial cancer. The role of EP3 expression in ovarian cancer is currently unknown. METHODS: EP3 expression was analyzed by immunohistochemistry in 156 patient samples using the IR-scoring system. Expression levels were correlated with clinical and pathological parameters and with overall survival (OS) to assess for prognostic relevance. Data analysis wa...
Source: Clin Med Res - September 4, 2019 Category: Research Authors: Czogalla B, Kuhn C, Heublein S, Schmöckel E, Mayr D, Kolben T, Trillsch F, Burges A, Mahner S, Jeschke U, Hester A Tags: J Cancer Res Clin Oncol Source Type: research

Phase 2 Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes.
CONCLUSIONS: In summary, galunisertib treatment has an acceptable safety profile and was associated with hematologic improvements in lower- and intermediate-risk MDS, with responses in heavily transfusion-dependent patients and in those with signs of an early stem cell differentiation block. ClinicalTrials.gov, number NCT02008318. PMID: 31481511 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 3, 2019 Category: Research Authors: Santini V, Valcárcel D, Platzbecker U, Komrokji RS, Cleverly A, Lahn MM, Janssen J, Zhao Y, Chiang A, Giagounidis A, Guba SC, Sridharan A, Gueorguieva I, Girvan A, da Silva Ferreira M, Bhagat TD, Pradhan K, Steidl U, Will B, Verma A Tags: Clin Cancer Res Source Type: research

Somatostatin and chemokine CXCR4 receptor expression in pancreatic adenocarcinoma relative to pancreatic neuroendocrine tumours.
CONCLUSIONS: SST or CXCR4 expression in PAC is clearly of no therapeutic relevance. However, indirect targeting of these tumours via SST3, SST5, or CXCR4 on tumour microvessels may represent a promising additional therapeutic strategy. PMID: 31451931 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 26, 2019 Category: Research Authors: Kajtazi Y, Kaemmerer D, Sänger J, Schulz S, Lupp A Tags: J Cancer Res Clin Oncol Source Type: research

Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients.
This study analyzed PCT and CRP levels of 214 pediatric patients with a median age of 8.5 years (0.4-17.8 years) undergoing allogeneic HSCT with respect to major TRAE. RESULTS: 26 patients (12.1%) did not experience TRAE (control group), and 188 (87.9%) experienced median 2 (range 1-4) TRAE. Median CRP and PCT were highly and significantly increased during sepsis/SIRS and bacteremia (17.24 mg/dl | 6.30 ng/ml; p 
Source: Clin Med Res - August 24, 2019 Category: Research Authors: Cabanillas Stanchi KM, Queudeville M, Malaval C, Feucht J, Schlegel P, Dobratz M, Seitz C, Müller I, Lang P, Handgretinger R, Döring M Tags: J Cancer Res Clin Oncol Source Type: research

Impact of interventions and tumor stage on health-related quality of life in patients with hepatocellular carcinoma.
This study aims to examine the health-related quality of life in patients with hepatocellular carcinoma. METHODS: 181 patients attending a tertiary center outpatient clinic were interviewed and completed the short form 36 (SF36) questionnaire. The SF36 was used to assess health-related QoL. Cross-sectional analyses by group (age, gender, clinical scores, systemic, and local interventions) as well sequel questionnaires were conducted. RESULTS: Participants included were 79% (143/181) men [mean age at first SF36: 63.8 (± 12.3; 18.4-85.8) years]. Barcelona Clinic Liver Cancer (BCLC) stadium C was ...
Source: Clin Med Res - August 19, 2019 Category: Research Authors: Wehling C, Hornuss D, Schneider P, Springfeld C, Hoffmann K, Chang DH, Naumann P, Mieth M, Longerich T, Kratochwil C, Mehrabi A, Gauss A, Weiss KH, Pfeiffenberger J Tags: J Cancer Res Clin Oncol Source Type: research

The role of autologous stem cell transplantation in peripheral T cell lymphoma: a long-term follow-up single-center experience.
CONCLUSIONS: Our study suggests that autoSCT can achieve long-term survival in PTCL patients even after relapse and should also be considered for eligible older patients. PMID: 31410605 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 13, 2019 Category: Research Authors: Roerden M, Walz JS, Müller MR, Sökler M, Federmann B, Kanz L, Bethge W, Vogel W Tags: J Cancer Res Clin Oncol Source Type: research

Meeting report of the 7th Heidelberg Myeloma Workshop: today and tomorrow.
CONCLUSION: Diagnostics and treatment of newly diagnosed and relapsed MM are continuously evolving. While advances in the field of (single cell) genetic analysis now allow for characterization of the disease at an unprecedented resolution, immunotherapeutic approaches and MRD testing are at the forefront of the current clinical trial landscape. PMID: 31407112 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 12, 2019 Category: Research Authors: Baertsch MA, Lutz R, Raab MS, Weinhold N, Goldschmidt H Tags: J Cancer Res Clin Oncol Source Type: research

Adenosine stress perfusion cardiac magnetic resonance imaging in patients undergoing intracoronary bone marrow cell transfer after ST-elevation myocardial infarction: the BOOST-2 perfusion substudy.
ulich S Abstract AIMS: In the placebo-controlled, double-blind BOne marrOw transfer to enhance ST-elevation infarct regeneration (BOOST) 2 trial, intracoronary autologous bone marrow cell (BMC) transfer did not improve recovery of left ventricular ejection fraction (LVEF) at 6 months in patients with ST-elevation myocardial infarction (STEMI) and moderately reduced LVEF. Regional myocardial perfusion as determined by adenosine stress perfusion cardiac magnetic resonance imaging (S-CMR) may be more sensitive than global LVEF in detecting BMC treatment effects. Here, we sought to evaluate (i) the changes of myo...
Source: Clin Med Res - August 10, 2019 Category: Research Authors: Seitz A, Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, May AE, Empen K, Chorianopoulos E, Ritter B, Pirr J, Arseniev L, Heuft HG, Ganser A, Abu-Zaid E, Katus HA, Felix SB, Gawaz MP, Schultheiss HP, Ladage D, Bauersachs J, Mahrholdt H, Greulich S Tags: Clin Res Cardiol Source Type: research

FIFA World Cup 2018: effect of emotional stress on conventional heart rate variability metrics.
Abstract PMID: 31388740 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 6, 2019 Category: Research Authors: Hamm W, Bogner-Flatz V, Bauer A, Brunner S Tags: Clin Res Cardiol Source Type: research

Long-term effects of baroreflex activation therapy: 2-year follow-up data of the BAT Neo system.
Koziolek MJ Abstract OBJECTIVE: Baroreflex activation therapy (BAT) reduces office blood pressure (BP) in patients with resistant hypertension (HTN). Whereas sustained effects from the BAT Rheos device have already been reported, no long-term data on 24-h ambulatory BP (ABP) are currently available for the unilateral BAT Neo device. METHODS: Patients treated with the BAT neo device for resistant hypertension were prospectively included into this observational study. Office and ABP measurements were performed before BAT implantation as well as 6, 12 and 24 months after initiation of BAT. RESULTS: A t...
Source: Clin Med Res - August 6, 2019 Category: Research Authors: Wallbach M, Born E, Kämpfer D, Lüders S, Müller GA, Wachter R, Koziolek MJ Tags: Clin Res Cardiol Source Type: research

Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.
Abstract In the original publication of this article [1], the Gene Expression Omnibus (GEO) accession code GSE79772 is wrong. The correct accession code should be GSE86213. PMID: 31358019 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - July 29, 2019 Category: Research Authors: Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H Tags: J Exp Clin Cancer Res Source Type: research

Circulating Tumor Cell Clusters in Metastatic Breast Cancer Patients: a SWOG S0500 Translational Medicine Study.
Abstract PURPOSE: Metastasis requires malignant cell circulation from the primary to a distant tissue. Elevated levels of circulating tumor cells (CTC) portend a poor prognosis in breast and other cancers. Recent studies have suggested that CTC clusters may be a factor in the metastatic process. We conducted a prospective retrospective study of the SWOG0500 clinical trial to test whether CTC clusters are associated with poorer prognosis. EXPERIMENTAL DESIGN: CTC CellSearch® galleries from SWOG0500 trial were re-read using pre-specified criteria for CTC clusters, doublets, and enumeration. Survival analysi...
Source: Clin Med Res - July 29, 2019 Category: Research Authors: Paoletti C, Miao J, Dolce EM, Darga EP, Repollet MI, Doyle GV, Gralow JR, Hortobagyi GN, Smerage JB, Barlow WE, Hayes DF Tags: Clin Cancer Res Source Type: research