Hypoglycemia, Malnutrition and Body Composition.
Abstract Hypoglycemia is one of the most significant factors to affect prognosis, and is detrimental to patients regardless of diabetes mellitus (DM) status. The classical paradigms dictate that hypoglycemia is a result of overtreatment with glucose lowering agents (iatrogenic hypoglycemia), or, as among patients without DM, this condition is attributed to disease severity. New information shows that hypoglycemia occurs among patients that have a tendency for it. Incident hypoglycemia is very prevalent in the hospital setting, occurring in 1:6 patients with DM and in 1:17 patients without DM (Leibovitz E, Khanimov...
Source: Clin Med Res - January 21, 2021 Category: Research Authors: Khanimov I, Shimonov M, Wainstein J, Leibovitz E Tags: Adv Exp Med Biol Source Type: research

Metformin-induced weight loss in patients with or without type 2 diabetes/prediabetes: A retrospective cohort study.
Abstract It is unknown whether weight loss outcomes differ with metformin monotherapy in patients with obesity with or without type 2 diabetes (T2DM)/prediabetes (PreDM). In this retrospective study, 6- or 12-month weight loss outcomes were compared in 222 patients with or without T2DM/preDM who completed metformin monotherapy. Average weight loss was similar between groups, euglycemic vs. T2DM/preDM (6 months: 6.5 [6.0%] vs. 6.5 [6.1%] p = 0.97; 12 months: 7.4 [6.2%] vs. 7.3 [7.7%], p = 0.92). Categorical weight losses (≥5% and ≥10% of baseline weight) were also similar. Comparable clinically significant we...
Source: Clin Med Res - December 29, 2020 Category: Research Authors: Chukir T, Mandel L, Tchang BG, Al-Mulla NA, Igel LI, Kumar RB, Waitman J, Aronne LJ, Shukla AP Tags: Obes Res Clin Pract Source Type: research

Prevalence of diabetes and pre-diabetes in Greece. Results of the First National Survey of Morbidity and Risk Factors (EMENO) study.
Abstract AIMS: To report the results of the first national Health Examination Survey (HES) on the prevalence of diabetes, its pharmacologic treatment and level of control, as well as pre-diabetes in Greece. METHODS: Data were derived from the National Survey of Morbidity and Risk Factors (EMENO), in a randomly selected, representative sample of the adult Greek population. Sampling weights were applied to adjust for study design and post-stratification weights to match sample age/sex distribution to the population. Non-response was adjusted by inverse probability weighting. Weighted prevalence estimates are pr...
Source: Clin Med Res - December 24, 2020 Category: Research Authors: Makrilakis K, Kalpourtzi N, Ioannidis I, Iraklianou S, Raptis A, Sotiropoulos A, Gavana M, Vantarakis A, Kantzanou M, Hadjichristodoulou C, Chlouverakis G, Trypsianis G, Voulgari PV, Alamanos Y, Touloumi G, Liatis S, EMENO Study Group Tags: Diabetes Res Clin Pract Source Type: research

Risk of hypoglycemia in Japanese people with type 2 diabetes mellitus who initiated or switched to insulin glargine 300 U/mL: A subgroup analysis of 12-month post-marketing surveillance study (X-STAR study).
This study investigated the hypoglycemia risk in people with type 2 diabetes (T2D) who initiated or switched to insulin glargine 300 U/mL (Gla-300) by stratifying them by age and renal function. METHODS: We examined data from 4,621 people with T2D (1,227 insulin-naïve and 3,394 insulin-experienced) of the X-STAR study, a prospective, observational, 12-month study conducted from December 2015 to August 2018 in Japan. Participants were stratified by age (
Source: Clin Med Res - December 24, 2020 Category: Research Authors: Hirose T, Odawara M, Matsuhisa M, Koshida R, Senda M, Tanaka Y, Terauchi Y Tags: Diabetes Res Clin Pract Source Type: research

Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection.
CONCLUSIONS: Severe COVID-19 infection with hypoxemia is associated with neuropathic symptoms and widespread sensory dysfunction in patients with DM. PMID: 33346072 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 17, 2020 Category: Research Authors: Odriozola A, Ortega L, Martinez L, Odriozola S, Torrens A, Corroleu D, Martínez S, Ponce M, Meije Y, Presas M, Duarte A, Belén Odriozola M, Malik RA Tags: Diabetes Res Clin Pract Source Type: research

Correction to: LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma.
PMID: 33298087 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - December 9, 2020 Category: Research Authors: Teng F, Zhang JX, Chang QM, Wu XB, Tang WG, Wang JF, Feng JF, Zhang ZP, Hu ZQ Tags: J Exp Clin Cancer Res Source Type: research

Transient elastography through controlled attenuated parameter assisting the stratification of cardiovascular disease risk in NAFLD patients.
CONCLUSION: A CAP value above 295 dB/m independently increased the incidence of CV events up to 8-times. Transient elastography, through CAP, is a safe and cost-effective method to evaluate NAFLD, and should be considered in the stratification of CV risk. PMID: 33279452 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 2, 2020 Category: Research Authors: de Sousa Magalhães R, Xavier S, Magalhães J, Rosa B, Marinho C, Cotter J Tags: Clin Res Hepatol Gastroenterol Source Type: research

Risk of lung cancer and renin-angiotensin blockade: a concise review.
CONCLUSION: Until more comprehensive analyses have been completed, there is no need to change clinical practise. Additional prospective randomized trials with long-term follow-up are needed to investigate the effects of these drugs on the development and progression of lung cancer. PMID: 33231730 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 24, 2020 Category: Research Authors: Rachow T, Schiffl H, Lang SM Tags: J Cancer Res Clin Oncol Source Type: research

Correction to: Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma.
Abstract In the original article published, the data of AJCC stage. PMID: 33236216 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 24, 2020 Category: Research Authors: Iwasaki T, Kohashi K, Toda Y, Ishihara S, Yamada Y, Oda Y Tags: J Cancer Res Clin Oncol Source Type: research

Clinical features of immune-mediated hepatotoxicity induced by immune checkpoint inhibitors in patients with cancers.
Abstract PURPOSE: The risk factors and clinical characteristics of ICI-induced immune-mediated hepatotoxicity (IMH) are not fully understood. Thus, the present study sought to clarify the clinical features of IMH. METHODS: All patients treated with ICIs between September 2014 and April 2019 at our institution were included. Clinical data were retrospectively collected from medical records. The frequency of grade ≥ 2 liver damage, clinical characteristics, and risk factors for developing IMH were examined. RESULTS: Overall, 250 patients (median age 71 years; range 30-87 years; 2...
Source: Clin Med Res - November 22, 2020 Category: Research Authors: Yamamoto A, Yano Y, Ueda Y, Yasutomi E, Hatazawa Y, Hayashi H, Yoshida R, Asaji N, Shiomi Y, Tobimatsu K, Sakai A, Kodama Y Tags: J Cancer Res Clin Oncol Source Type: research

Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study.
ker T, Pons-Kühnemann J, Schächinger V, Schieffer B, Schott P, Schulze M, Teupe C, Vasa-Nicotera M, Weber M, Weinbrenner C, Werner G, Hamm CW, Dörr O, CoVCAD –Study Group Abstract AIMS: During the COVID-19 pandemic, hospital admissions for cardiac care have declined. However, effects on mortality are unclear. Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths. Simultaneously we looked at catheterization activities in the same region. METHODS AND RESULTS: Data from 22 of 24 public health-authorities in central Germany were ...
Source: Clin Med Res - November 21, 2020 Category: Research Authors: Nef HM, Elsässer A, Möllmann H, Abdel-Hadi M, Bauer T, Brück M, Eggebrecht H, Ehrlich JR, Ferrari MW, Fichtlscherer S, Hink U, Hölschermann H, Kacapor R, Koeth O, Korboukov S, Lamparter S, Laspoulas AJ, Lehmann R, Liebetrau C, Plücker T, Pons-Kühnem Tags: Clin Res Cardiol Source Type: research

Patterns of care and follow-up care of patients with uveal melanoma in German-speaking countries: a multinational survey of the German Dermatologic Cooperative Oncology Group (DeCOG).
CONCLUSION: Treatment patterns of patients with uveal melanoma in Germany, Austria and Switzerland remain extremely heterogeneous. A guideline for the treatment and surveillance is urgently needed. PMID: 33219855 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 21, 2020 Category: Research Authors: Steeb T, Wessely A, Alter M, Bayerl C, Bender A, Bruning G, Dabrowski E, Debus D, Devereux N, Dippel E, Drexler K, Dücker P, Dummer R, Emmert S, Elsner P, Enk A, Gebhardt C, Gesierich A, Goebeler M, Goerdt S, Goetze S, Gutzmer R, Haferkamp S, Hansel G, H Tags: J Cancer Res Clin Oncol Source Type: research

The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor.
CONCLUSION: This study demonstrates that FOXM1 may serve as a promising therapeutic target for MRT. PMID: 33221995 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 21, 2020 Category: Research Authors: Shibui Y, Kohashi K, Tamaki A, Kinoshita I, Yamada Y, Yamamoto H, Taguchi T, Oda Y Tags: J Cancer Res Clin Oncol Source Type: research

Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation.
CONCLUSIONS: The prediction scores adequately detected pAF using variables readily available during routine cardiac assessment and echocardiography. The model scores, denoted as ECHO-AF scores, represent simple, highly sensitive and non-invasive tools for detecting pAF that can be easily implemented in the clinical practice and might serve as screening test to initiate further diagnostic investigations for validating the presence of pAF. Prospective validation of a novel prediction model for paroxysmal atrial fibrillation based on echocardiography and medical history parameters by long-term Holter ECG. PMID: 33211156 ...
Source: Clin Med Res - November 19, 2020 Category: Research Authors: Schmidt C, Benda S, Kraft P, Wiedmann F, Pleger S, Büscher A, Thomas D, Wachter R, Schmid C, Eils R, Katus HA, Kallenberger SM Tags: Clin Res Cardiol Source Type: research

PD-1 inhibition therapy for advanced cutaneous squamous cell carcinoma: a retrospective analysis from the University of Southern California.
CONCLUSION: PD-1 inhibition produces durable responses among patients with advanced or metastatic CSCC. PD-1 inhibition therapy is well tolerated, but patients should be monitored closely for immune-related adverse events, particularly frail or immune-suppressed patients. Further investigation of potential biomarkers to help identify patients who will derive the most benefit from this therapeutic option is needed. PMID: 33210210 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 18, 2020 Category: Research Authors: In GK, Vaidya P, Filkins A, Hermel DJ, King KG, Ragab O, Tseng WW, Swanson M, Kokot N, Lang JE, Menendez L, DeClerck B, Kim G, Hu JC, Terando A, Jadvar H, Ricker C, Miller KA, Peng DH, Wysong A Tags: J Cancer Res Clin Oncol Source Type: research

Comparison of mechanical circulatory support with venoarterial extracorporeal membrane oxygenation or Impella for patients with cardiogenic shock: a propensity-matched analysis.
CONCLUSIONS: In this retrospective analysis of patients with CS, treatment with Impella 2.5/CP or vaECMO was associated with similar hospital and 6-month survival rates. Device-related access-site vascular complications occurred more frequently in the vaECMO group. A randomized trial is warranted to examine the effects of these devices on outcomes and to determine the optimal device choice in patients with CS. PMID: 33185749 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 13, 2020 Category: Research Authors: Karatolios K, Chatzis G, Markus B, Luesebrink U, Ahrens H, Divchev D, Syntila S, Jerrentrup A, Schieffer B Tags: Clin Res Cardiol Source Type: research

Outcome of patients treated with extracorporeal life support in cardiogenic shock complicating acute myocardial infarction: 1-year result from the ECLS-Shock study.
CONCLUSION: This pilot study showed that randomized studies with ECLS in CS patients are feasible and safe. Small numbers of included patients impede meaningful conclusions about mortality and neurological outcome. Our findings of numerical differences in mortality and survival with severe neurological impairment give an urgent call for larger multi-centric randomized trials assessing the endpoint of all-cause mortality but also considering the effects on neurological outcome measures. PMID: 33180150 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - November 12, 2020 Category: Research Authors: Lackermair K, Brunner S, Orban M, Peterss S, Orban M, Theiss HD, Huber BC, Juchem G, Born F, Boulesteix AL, Bauer A, Pichlmaier M, Hausleiter J, Massberg S, Hagl C, Guenther SPW Tags: Clin Res Cardiol Source Type: research

LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma.
CONCLUSIONS: MYLK-AS1 and E2F7 are closely related to some malignant clinicopathological features and prognosis of HCC, thus the MYLK-AS1/ miR-424-5p/E2F7 signaling pathway might represent a promising treatment strategy to combat HCC. PMID: 33168027 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - November 9, 2020 Category: Research Authors: Teng F, Zhang JX, Chang QM, Wu XB, Tang WG, Wang JF, Feng JF, Zhang ZP, Hu ZQ Tags: J Exp Clin Cancer Res Source Type: research

Lysine-specific histone demethylase 1A (LSD1) in cervical cancer.
CONCLUSIONS: Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations. PMID: 32725356 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - October 8, 2020 Category: Research Authors: Beilner D, Kuhn C, Kost BP, Jückstock J, Mayr D, Schmoeckel E, Dannecker C, Mahner S, Jeschke U, Heidegger HH Tags: J Cancer Res Clin Oncol Source Type: research

Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing's sarcoma cells.
CONCLUSION: Our findings show that PLK4 inhibitors were effective against Ewing's sarcoma cells in vitro and thus provide a rationale for their evaluation in vivo. PMID: 32770382 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - October 8, 2020 Category: Research Authors: Kerschner-Morales SL, Kühne M, Becker S, Beck JF, Sonnemann J Tags: J Cancer Res Clin Oncol Source Type: research

Systemic treatment of advanced/metastatic renal cell carcinoma in the context of SARS-CoV-2 pandemic: recommendations from the interdisciplinary working group for renal tumors (IAG-N).
y (DKG) Abstract This letter summarizes recommendations from the interdisciplinary working group of renal tumors (IAGN) of the German Cancer Society for the systemic treatment of advanced/metastatic renal cell carcinoma in the context of the current SARS-CoV-2 pandemic. PMID: 32816108 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - October 3, 2020 Category: Research Authors: Ivanyi P, Grüllich C, Kroeger N, Gauler T, Johannsen M, Bedke J, Grünwald V, Interdisciplinary working group on renal tumors (IAG-N) of the German Cancer Socity (DKG) Tags: J Cancer Res Clin Oncol Source Type: research

Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.
CONCLUSION: According to the described effects on EOC biology, all three Wnt manipulators seem to have the potential to augment the impact of a platinum-based chemotherapy in EOC. This is promising as a dominance of this pathway was confirmed in serous histology. PMID: 32681294 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - September 17, 2020 Category: Research Authors: Kaltofen T, Preinfalk V, Schwertler S, Fraungruber P, Heidegger H, Vilsmaier T, Vattai A, Czogalla B, Mayr D, Mahner S, Jeschke U, Trillsch F Tags: J Cancer Res Clin Oncol Source Type: research

Implications of flavonoids as potential modulators of cancer neovascularity.
CONCLUSION: Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest. PMID: 32902794 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 8, 2020 Category: Research Authors: Liskova A, Koklesova L, Samec M, Varghese E, Abotaleb M, Samuel SM, Smejkal K, Biringer K, Petras M, Blahutova D, Bugos O, Pec M, Adamkov M, Büsselberg D, Ciccocioppo R, Adamek M, Rodrigo L, Caprnda M, Kruzliak P, Kubatka P Tags: J Cancer Res Clin Oncol Source Type: research

Distribution of the HTT gene A1 and A2 haplotypes worldwide: A systematic review.
CONCLUSION: Regardless of the size of the CAG tract, the articles included in this review demonstrate that populations with high HD prevalence present higher frequencies of the A1 or A2 haplotypes than populations exhibiting low HD prevalence, even when similar average CAG numbers are noted. Based on the presented articles, we suggest that the haplotypic profile is more closely related to the ancestral origin than to the size of the CAG tract. The identification of populations presenting a higher frequency of high-risk genotypes can contribute to more accurate genetic counseling, in addition to providing knowledge on HD ep...
Source: Clin Med Res - September 1, 2020 Category: Research Authors: Apolinário TA, Rodrigues DC, Lemos MB, Paiva CLA, Agostinho LA Tags: Clin Med Res Source Type: research

Repeat Pregnancy after Prior Aortic Valve-in-Valve Replacement: Cautionary Tale.
We describe the first result of a repeat pregnancy outcome in a woman with a history of prior TAVR in SAVR. Both maternal and fetal outcomes were favorable, but maternal cardiac complications observed in the third trimester emphasize our concerns regarding risk for cardiac complications in subsequent pregnancies in patients with a prior TAVR in SAVR. Despite the maternal complications that occurred during repeat pregnancy in this patient, a successful pregnancy outcome reaffirms our recommendation to utilize a multidisciplinary team for pregnancy management in patients with prior TAVR or TAVR in SAVR and to help in the man...
Source: Clin Med Res - September 1, 2020 Category: Research Authors: Rasmussen K, Rokey R, Rolak SC, Zhong C, Braxton JH, Hashimoto K Tags: Clin Med Res Source Type: research

Response rate and safety in patients with hepatocellular carcinoma treated with transarterial chemoembolization using 40- µm doxorubicin-eluting microspheres.
CONCLUSION: Superselective DEB-TACE with 40-µm sized Embozene Tandem™ can be considered an effective and safe treatment, given the number of procedure-related complications. PMID: 32880029 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - September 1, 2020 Category: Research Authors: Albrecht KC, Aschenbach R, Diamantis I, Eckardt N, Teichgräber U Tags: J Cancer Res Clin Oncol Source Type: research

Mechanical revision following pedicle subtraction osteotomy: a competing risk survival analysis in 171 consecutive adult spinal deformity patients.
CONCLUSIONS: In a consecutive single-center cohort of patients undergoing PSO for ASD, we found an estimated incidence of revision surgery due to mechanical failure of 34% 2 years postoperatively. Fusion to the sacrum and preoperative PT > 20° were associated with elevated risks of revision. LEVEL OF EVIDENCE: Prognostic III. PMID: 32875546 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - August 31, 2020 Category: Research Authors: Bari TJ, Hallager DW, Hansen LV, Dahl B, Gehrchen M Tags: Spine Deform Source Type: research

Gastrointestinal Bleeding as a Complication in Continuous Flow Ventricular Assist Devices: A Systematic Review With Meta-Analysis.
Conclusions: The result obtained from this research indicates that the occurrence of gastrointestinal bleeding is not significantly different in both groups of patients, irrespective of the type of continuous flow VAD used. Although, the study sample used in this meta-analysis was limited. PMID: 32849943 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Asuka E, Pak S, Thiess AK, Torres A Tags: J Clin Med Res Source Type: research

The Clinical Benefit of Adjuvant Therapy in Long-Term Survival of Early-Stage Ampullary Carcinoma: A Single Institutional Experience.
Conclusions: In the early-stage AC, adjuvant therapy may not improve the outcome in the short term but may benefit over a long period. It should be considered, especially in patients with adverse risk factors. Radiation therapy may not be useful in managing AC in the adjuvant setting. PMID: 32849944 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Manne A, Hatic H, Li P, Jacob R, Williams G, Paluri R Tags: J Clin Med Res Source Type: research

Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition.
Conclusions: Individuals with CP, but not healthy individuals or those after clinical resolution of AP, are characterized by elevated circulating levels of periostin that are positively associated with intra-pancreatic fat deposition. PMID: 32849945 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Ko J, Stuart CE, Modesto AE, Cho J, Bharmal SH, Petrov MS Tags: J Clin Med Res Source Type: research

Validity of Serum miRNA 93 and miRNA 191 to Reduce Unnecessary Computed Tomography in Patients With Mild Head Trauma.
Conclusions: Circulating miRNA levels increased after MHT and differentiated patients with and without intracranial or extracranial lesions demonstrable on CCT. Adding the measurement of serum miRNAs particularly miR191 to the clinical decision rules for a CCT scan in patients with MHI could allow a reduction in scans. PMID: 32849946 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Tas D, Kaplan O, Sogut O Tags: J Clin Med Res Source Type: research

A Controllable Inflammatory Response and Temporary Abnormal Coagulation in Moderate Disease of COVID-19 in Wuhan, China.
Conclusions: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a controllable inflammatory response in moderate disease of COVID-19 in Wuhan, China. Since patients older than 60 years had higher inflammatory state and more dysregulated coagulation condition, it might be essential to closely assess their illness. PMID: 32849947 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Liu Y, Zhang X, Qiao J, Gong R, You Q, Sun J, Liu W, Sun B Tags: J Clin Med Res Source Type: research

Association Between Serum Apolipoprotein A1 Levels, Ischemic Stroke Subtypes and Plaque Properties of the Carotid Artery.
Conclusions: These findings suggest that serum ApoA1 levels might be associated with the development of ATBI and plaque properties of the carotid artery. PMID: 32849948 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Ohtani R, Nirengi S, Sakane N Tags: J Clin Med Res Source Type: research

Effects of Short-Term Hydroxychloroquine Plus Moxifloxacin Therapy on Corrected QT Interval and Tp-e Interval in Patients With COVID-19.
Conclusions: HCQ + MOX combination therapy led to increases in QTc interval, Tp-e interval, and cTp-e interval. However, this therapy did not cause ventricular arrhythmia in the short-term observation. PMID: 32849949 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Afsin A, Ecemis K, Asoglu R Tags: J Clin Med Res Source Type: research

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus.
Conclusions: The serum irisin level in T2DM group was significantly lower than that in control group, suggesting that irisin may be a protective factor for type 2 diabetes. PMID: 32849950 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Xuan X, Lin J, Zhang Y, Zhou L, Xu L, Jia J, Zhao B, Lin Z, Zhu Q, Li L, Wu T, Zhang S, Jiang H, Wang Y Tags: J Clin Med Res Source Type: research

Trace Proteinuria and the Incidence of Overt Proteinuria After Five Years: Results of the Kanagawa Investigation of the Total Checkup Data From the National Database-5 (KITCHEN-5).
Conclusions: Our findings suggest that TrP, particularly R-TrP, is substantially associated with the future incidence of OP, which may be independent of confounding factors and the methods detecting TrP. PMID: 32849951 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Nakajima K, Higuchi R, Mizusawa K Tags: J Clin Med Res Source Type: research

An Atypical Presentation of COVID-19 in a Previously Healthy Young Male With a Rare Cause of Abdominal Pain.
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by a newly discovered coronavirus that has reached pandemic proportions impacting millions globally. Authors feature an atypical case of COVID-19 presenting with a rare cause of abdominal pain and severe hyperglycemia. A 22-year-old male presented to the hospital with a 1-day history of severe abdominal pain. An abdominal computed tomography (CT) scan revealed findings of epiploic appendagitis (EA) and incidentally noted suspicious pulmonary lesions suggestive of COVID-19. Radiographic findings and distinctive laboratory results ...
Source: Clin Med Res - August 29, 2020 Category: Research Authors: Bashari DR, Peguero-Tejada JL, Shah JI Tags: J Clin Med Res Source Type: research

Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide.
This study aimed to further evaluate the prognostic role of age in a homogenously treated patient cohort. METHODS: The study includes 132 IDH-wildtype glioblastoma patients treated between 2013 and 2017 with open resection followed by radiotherapy with concomitant and maintenance temozolomide. Patients were dichotomized into a non-elderly (
Source: Clin Med Res - August 2, 2020 Category: Research Authors: Berger K, Turowski B, Felsberg J, Malzkorn B, Reifenberger G, Steiger HJ, Budach W, Haussmann J, Knipps J, Rapp M, Hänggi D, Sabel M, Mijderwijk HJ, Kamp MA Tags: J Cancer Res Clin Oncol Source Type: research

Effect of renal denervation in attenuating the stress of morning surge in blood pressure: post-hoc analysis from the SPYRAL HTN-ON MED trial.
CONCLUSIONS: This decrease in the morning DBP surge slope, an index of the sympathetically-mediated morning BP surge, thus indicates a drop in late morning BP relative to early morning/nocturnal BP in the RDN group. Thus, RDN appears effective in attenuating the slope of morning surge in DBP that might indicate possible benefits in a high-risk hypertensive population. CLINICAL TRIAL REGISTRATION: https://www.clinicaltrials.gov (NCT02439775), registered May 12, 2015. PMID: 32740754 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 31, 2020 Category: Research Authors: Kario K, Weber MA, Böhm M, Townsend RR, Mahfoud F, Schmieder RE, Tsioufis K, Cohen SA, Fahy M, Kandzari DE Tags: Clin Res Cardiol Source Type: research

Current treatment options in RAS mutant metastatic colorectal cancer patients: a meta-analysis of 14 randomized phase III trials.
CONCLUSION: The therapeutic benefit of additional substances is less distinct in patients with RAS mutated as compared to RAS wildtype metastatic colorectal cancer, especially with regard to OS. PMID: 32561975 [PubMed - indexed for MEDLINE] (Source: Clin Med Res)
Source: Clin Med Res - July 15, 2020 Category: Research Authors: Stahler A, Heinemann V, Ricard I, von Einem JC, Giessen-Jung C, Westphalen CB, Michl M, Heinrich K, Miller-Phillips L, Jelas I, Stintzing S, Modest DP Tags: J Cancer Res Clin Oncol Source Type: research

Collateral damage of COVID-19-lockdown in Germany:  decline of NSTE-ACS admissions.
Collateral damage of COVID-19-lockdown in Germany: decline of NSTE-ACS admissions. Clin Res Cardiol. 2020 Jul 10;: Authors: Gitt AK, Karcher AK, Zahn R, Zeymer U PMID: 32651656 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 9, 2020 Category: Research Authors: Gitt AK, Karcher AK, Zahn R, Zeymer U Tags: Clin Res Cardiol Source Type: research

Comments on 'Recurrent sigmoid volvulus in a patient with Parkinson's disease': authors' response.
PMID: 32638181 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 6, 2020 Category: Research Authors: Sakakibara R Tags: Clin Auton Res Source Type: research

Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota.
Abstract The present study investigated whether or not the oral administration of trehangelin-A (THG-A) is effective for metabolic disorders caused by a high-fat diet, as we previously showed that the intraperitoneal administration of THG-A improved metabolic disorders caused by a high-fat diet. Mice received a control diet or high-fat diet for eight weeks. Concurrently, mice were orally administered 0.2 ml/mouse phosphate-buffered saline (PBS) or 1 or 10 mg/0.2 ml/mouse of THG-A once daily during the experiment. The weight gain caused by a high-fat diet was significantly suppressed by oral THG-A compared to a hig...
Source: Clin Med Res - June 30, 2020 Category: Research Authors: Ishikawa H, Ino S, Nakashima T, Matsuo H, Takahashi Y, Kohda C, Ōmura S, Iyoda M, Tanaka K Tags: Obes Res Clin Pract Source Type: research

Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection.
CONCLUSION: Impaired cardiac function is associated with poor prognosis in COVID-19 positive patients. Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic. PMID: 32537662 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 13, 2020 Category: Research Authors: Rath D, Petersen-Uribe Á, Avdiu A, Witzel K, Jaeger P, Zdanyte M, Heinzmann D, Tavlaki E, Müller K, Gawaz MP Tags: Clin Res Cardiol Source Type: research

Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients.
CONCLUSION: Depending on nuclear or cytoplasmic expression, our study shows that THRα and its isoforms 1 and 2 provide different prognostic information for ovarian cancer patients. Further investigations should analyze if THRs may represent new endocrine targets for the treatment of ovarian cancer. PMID: 32533406 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 11, 2020 Category: Research Authors: Ditsch N, Heublein S, Jeschke U, Sattler C, Kuhn C, Hester A, Czogalla B, Trillsch F, Mahner S, Engel J, Mayr D, Schmoeckel E Tags: J Cancer Res Clin Oncol Source Type: research

Retrospective observation of children with the diagnosis of postural tachycardia syndrome while on atomoxetine.
PMID: 32514797 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 7, 2020 Category: Research Authors: Go S, Takahashi R, Suzuki S, Kasuga A, Morichi S, Ishida Y, Yamanaka G, Kashiwagi Y, Kawashima H Tags: Clin Auton Res Source Type: research

Response to the letter to the editor by Nagai M et al. entitled "Right insular cortex atrophy in Takotsubo syndrome: a possible pathogenesis of increased sympathetic nervous system activity?"
Response to the letter to the editor by Nagai M et al. entitled "Right insular cortex atrophy in Takotsubo syndrome: a possible pathogenesis of increased sympathetic nervous system activity?" Clin Res Cardiol. 2020 Jun 03;: Authors: Barbieri F, Tuovinen N, Steiger R, Dichtl W PMID: 32494922 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 2, 2020 Category: Research Authors: Barbieri F, Tuovinen N, Steiger R, Dichtl W Tags: Clin Res Cardiol Source Type: research

Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus.
CONCLUSIONS: We obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy. PMID: 32502691 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - June 1, 2020 Category: Research Authors: Sawada S, Tsuchiya S, Kodama S, Kurosawa S, Endo A, Sugawara H, Hosaka S, Kawana Y, Asai Y, Yamamoto J, Munakata Y, Izumi T, Takahashi K, Kaneko K, Imai J, Ito A, Yasuda M, Kunikata H, Nakazawa T, Katagiri H Tags: Diabetes Res Clin Pract Source Type: research

The diagnostic benefit of 16S rDNA PCR examination of infective endocarditis heart valves: a cohort study of 146 surgical cases confirmed by histopathology.
CONCLUSION: Valve PCR was found to be a valuable diagnostic tool in surgical endocarditis cases with negative blood cultures or positive blood cultures of unknown significance. TRIAL REGISTRATION: S-440/2017 on 28.08.2017 retrospectively registered. Subdividing of all infective endocarditis patients in this study, showing that valve PCR yields valuable information for patients with skin commensals in blood cultures, which were either confirmed by the same detection in valve PCR or refuted by the detection of a different and typical pathogen in valve PCR. Additionally, benefit was determined in patients with negative o...
Source: Clin Med Res - June 1, 2020 Category: Research Authors: Armstrong C, Kuhn TC, Dufner M, Ehlermann P, Zimmermann S, Lichtenstern C, Soethoff J, Katus HA, Leuschner F, Heininger A Tags: Clin Res Cardiol Source Type: research

Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).
CONCLUSION: These results indicated that EP3 signaling pathway might facilitate the migration of cervical cancer cells through modulating uPAR expression. Therefore, EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages. PMID: 32488496 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 31, 2020 Category: Research Authors: Ye Y, Peng L, Vattai A, Deuster E, Kuhn C, Dannecker C, Mahner S, Jeschke U, von Schönfeldt V, Heidegger HH Tags: J Cancer Res Clin Oncol Source Type: research