Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices.
CONCLUSION: Implementation of an IFUP for VAD patients is associated with a significant decrease in 1-year all-cause mortality. This emphasizes the need for more vigilance in the management of VAD patients by a dedicated multi-disciplinary team. PMID: 30879094 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - March 16, 2019 Category: Research Authors: Hamed S, Schmack B, Mueller F, Ehlermann P, Hittmann D, Ruhparwar A, Katus HA, Raake PW, Kreusser MM Tags: Clin Res Cardiol Source Type: research

Use of Fenofibrate for patients with primary Sclerosing Cholangitis.
PMID: 30880099 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - March 14, 2019 Category: Research Authors: Abdalla SM, Dejman A, Clark V, Levy C Tags: Clin Res Hepatol Gastroenterol Source Type: research

C-peptide predicts all-cause and cardiovascular death in a cohort of individuals with newly diagnosed type 2 diabetes. The Skaraborg diabetes register.
ouml;m K Abstract AIMS: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes. METHODS: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons
Source: Clin Med Res - March 13, 2019 Category: Research Authors: Pikkemaat M, Andersson T, Melander O, Chalmers J, Rådholm K, Bengtsson Boström K Tags: Diabetes Res Clin Pract Source Type: research

Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease.
Abstract Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans. Hence, we aim to determine whether global cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery perfusion] is associated with increases in amyloid deposition in the hemisphere with atherosclerotic major cerebral artery disease in patients. We evaluated the distribution of β-amyloid plaques using posi...
Source: Clin Med Res - March 12, 2019 Category: Research Authors: Yamauchi H, Kagawa S, Takahashi M, Oishi N, Ono M, Higashi T Tags: Neuroimage Clin Source Type: research

Antim üllerian Hormone Levels Of Infants With Premature Thelarche
Conclusion: This is the first study that investigates AMH levels in infants with premature thelarche. It was concluded that AMH may play a role of suppressing pubertal findings during the infancy and decreased AMH may cause premature thelarche in infants because detected AMH levels in infants with premature thelarche were less than compared to healthy controls and there exists a negative correlation between AMH and FSH. PMID: 30859797 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - March 12, 2019 Category: Research Authors: Muratoglu Sahin N, Bayramoglu E, Nursun Ozcan H, Kurnaz E, Keskin M, Savas Erdeve S, Cetinkaya S, Aycan Z Tags: J Clin Res Pediatr Endocrinol Source Type: research

Lipoprotein(a)-antisense therapy.
Abstract Elevated levels of lipoprotein(a) (Lp(a)) contribute to the risk of early and severe cardiovascular disease (CVD) and Lp(a) is acknowledged as a risk factor to be included in risk assessment. The established lipid-modifying medical therapies do not lower Lp(a) except niacin but no data of endpoint trials are available. Of the new lipid-modifying drugs a few have some impact on Lp(a). Whether the Lp(a) lowering effect contributes to the reduction of CVD events would have to be shown in Lp(a) dedicated trials. None of the available agents is indicated to lower Lp(a). Lipoprotein apheresis lowers l...
Source: Clin Med Res - March 11, 2019 Category: Research Authors: Vogt A Tags: Clin Res Cardiol Suppl Source Type: research

Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region.
Abstract In the middle of the 1990s the interest in Lp(a) vanished after a few badly performed studies almost erased Lp(a) from the map of biological targets. However, since roughly 10 years the interest has begun to grow again mainly for two reasons: first, genetic studies using easily accessible and high-throughput techniques for genotyping of single-nucleotide polymorphisms (SNPs) have allowed large studies in patients with cardiovascular disease and controls to be performed. This strengthened the earlier findings on a copy number variation in the LPA gene and its association with cardiovascular ...
Source: Clin Med Res - March 11, 2019 Category: Research Authors: Kronenberg F Tags: Clin Res Cardiol Suppl Source Type: research

Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers.
Abstract Molecular stratification of high-grade serous ovarian carcinoma (HGSC) for targeted therapy is a pertinent approach in improving prognosis of this highly heterogeneous disease. Enabling the same necessitates identification of class-specific biomarkers and their robust detection in the clinic. We have earlier resolved three discrete molecular HGSC classes associated with distinct functional behavior based on their gene expression patterns, biological networks, and pathways. An important difference revealed was that Class 1 is likely to exhibit cooperative cell migration (CCM), Class 2 undergoes epithelial ...
Source: Clin Med Res - March 8, 2019 Category: Research Authors: Kamble SC, Sen A, Dhake RD, Joshi AN, Midha D, Bapat SA Tags: J Clin Med Source Type: research

Mast cell-mediated splanchnic cholestatic inflammation.
CONCLUSIONS: In cholestatic rats, Ketotifen improves liver function and ascites, and also reduces pro-inflammatory mediators in the splanchnic area. The decrease in connective tissue mast cells in the mesenteric lymphatic complex due to the administration of Ketotifen would lead to the improvement of the inflammatory splanchnic response, and consequently the abovementioned complications. PMID: 30853494 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - March 7, 2019 Category: Research Authors: Aller MÁ, Martínez V, Arias A, Nava MP, Cuervas-Mons V, Vergara P, Arias J Tags: Clin Res Hepatol Gastroenterol Source Type: research

Status of Emergency Department Seventy-Two Hour Return Visits Among Homeless Patients.
Abstract Background: We aim to externally validate the status of emergency department (ED) appropriate utilization and 72-h ED returns among homeless patients. Methods: This is a retrospective single-center observational study. Patients were divided into two groups (homeless versus non-homeless). Patients' general characteristics, clinical variables, ED appropriate utilization, and ED return disposition deviations were compared and analyzed separately. Results: Study enrolled a total of 63,990 ED visits. Homeless patients comprised 9.3% (5,926) of visits. Higher ED 72-h returns occurred among homeless pa...
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Knowles H, Huggins C, Robinson RD, Mbugua R, Laureano-Phillips J, Trivedi SM, Kirby J, Zenarosa NR, Wang H Tags: J Clin Med Res Source Type: research

Association of Oral Function With Long-Term Participation in Community-Based Oral Exercise Programs in Older Japanese Women: A Cross-Sectional Study.
Conclusions: Our results suggest that long-term participation in community salon exercise programs may suppress the deterioration of oral function in older people. Further study will be necessary to clarify the significant correlation between oral function and community-based social activities such as oral exercise. PMID: 30834038 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Miyoshi S, Shigeishi H, Fukada E, Nosou M, Amano H, Sugiyama M Tags: J Clin Med Res Source Type: research

Hyperbilirubinemia as a Predictor of Appendiceal Perforation: A Systematic Review and Diagnostic Test Meta-Analysis.
Conclusions: Hyperbilirubinemia alone is not a reliable tool to predict perforation. Future studies should investigate whether the combined predictive values of bilirubin, C-reactive protein (CRP), and white blood cells are a more effective diagnostic tool. PMID: 30834039 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Gavriilidis P, de'Angelis N, Evans J, Di Saverio S, Kang P Tags: J Clin Med Res Source Type: research

Relationship of Salivary Occult Blood With General and Oral Health Status in Employees of a Japanese Department Store.
Conclusions: The SOBT was a reliable screening method for periodontal disease, and positivity in the test was related to diabetes in Japanese employees. Further examinations are required to clarify the association of salivary occult blood with other systemic diseases. PMID: 30834040 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Segawa K, Shigeishi H, Fujii M, Noumi K, Yamanaka F, Kamikawa K, Arakawa S, Sugiyama M Tags: J Clin Med Res Source Type: research

Preoperative Depressive Mood of Patients With Esophageal Cancer Might Delay Recovery From Operation-Related Malnutrition.
Conclusion: Preoperative depressive mood, as evaluated by the SDS, was the sole relevant factor for postoperative body weight recovery of patients with esophageal cancer. Preoperative depressive mood of patients with esophageal cancer might delay recovery from operation-related malnutrition. Some measures against preoperative depressive mood might be necessary for early recovery from postoperative malnutrition in patients with esophageal cancer. PMID: 30834041 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Nakamura Y, Momoki C, Okada G, Matsumoto Y, Yasui Y, Habu D, Matsuda Y, Lee S, Osugi H Tags: J Clin Med Res Source Type: research

Human Papillomavirus Infection in Female Sex Workers: A Case Control Study.
Conclusions: No association between HPV infection and female sex work was found in our setting. High risk HPV genotypes were prevalent among the women studied. Results can be used for the design of preventive measures against HPV infection. PMID: 30834042 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Velazquez-Hernandez N, Sanchez-Anguiano LF, Guerra-Infante FM, Aguilar-Duran M, Perez-Alamos AR, Estrada-Martinez S, Navarrete-Flores JA, Sandoval-Carrillo AA, Antuna-Salcido EI, Hernandez-Tinoco J, Alvarado-Esquivel C Tags: J Clin Med Res Source Type: research

Effect of Switching to Azilsartan From Fixed-Dose Combination of an Angiotensin II Receptor Blocker and Calcium Channel Blocker or a Thiazide in Patients With Hypertension.
Conclusions: Azilsartan at 40 mg did not result in a greater decrease in BP than a fixed-dose combination tablet of an ARB/CCB or an ARB/HCT. However, our findings suggest a substantial BP-lowering effect of azilsartan at 40 mg in patients with hypertension. PMID: 30834043 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Miyoshi T, Onoue G, Ito H Tags: J Clin Med Res Source Type: research

A Retrospective Study of Kidney Stone Recurrence in Adults.
Conclusions: Majority of patients with KSD recurrence have overweight/obesity, hyperlipidemia, hyperuricemia and hyperglycemia, indicating a role of metabolic disorders in stone recurrence. Mini-invasive methods are the mainstay for the management of the first stone episode. The degree of hydronephrosis is significantly reduced during stone recurrence, possibly due to increased awareness of the disease and thereafter the change of lifestyle in patients. Over half of recurrent stones are of calcium oxalate. PMID: 30834044 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Zeng J, Wang S, Zhong L, Huang Z, Zeng Y, Zheng D, Zou W, Lai H Tags: J Clin Med Res Source Type: research

Risk Factors of Hypoglycemic Encephalopathy and Prolonged Hypoglycemia in Patients With Severe Hypoglycemia.
Abstract Background: The aim of the study was to investigate risk factors of hypoglycemic encephalopathy (HE) in patients with severe hypoglycemia. Methods: We retrospectively enrolled patients with severe hypoglycemia who were transported to the emergency department in an ambulance. We defined severe hypoglycemia as plasma glucose level
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Saikawa R, Yamada H, Suzuki D, Amamoto M, Matsumoto Y, Funazaki S, Yoshida M, Toyoshima H, Hara K Tags: J Clin Med Res Source Type: research

Liraglutide Reduces Visceral and Intrahepatic Fat Without Significant Loss of Muscle Mass in Obese Patients With Type 2 Diabetes: A Prospective Case Series.
Conclusions: In obese Japanese drug-naive patients who had type 2 diabetes, treatment with liraglutide (0.9 mg once daily for 24 weeks) reduced body fat, especially visceral fat and intrahepatic fat, while having no significant effect on skeletal muscle. PMID: 30834046 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 1, 2019 Category: Research Authors: Ishii S, Nagai Y, Sada Y, Fukuda H, Nakamura Y, Matsuba R, Nakagawa T, Kato H, Tanaka Y Tags: J Clin Med Res Source Type: research

Increased mortality in non-alcoholic fatty liver disease with chronic kidney disease is explained by metabolic comorbidities.
n S Abstract BACKGROUND: There is a close association between non-alcoholic fatty liver disease (NAFLD) and prevalent chronic kidney disease (CKD). Few longitudinal studies exist. No previous study has investigated to what extent CKD affects mortality in biopsy-proven NAFLD. Our aim was to investigate the long-term risk of developing CKD in biopsy-proven NAFLD and its effect on mortality. METHODS: Patients with biopsy-proven NAFLD diagnosed in 1978-2006 in Malmö, Sweden were included. Estimated glomerular filtration rate (eGFR) at baseline and last follow-up was calculated with the CKD-EPI equation. CKD ...
Source: Clin Med Res - February 28, 2019 Category: Research Authors: Önnerhag K, Dreja K, Nilsson PM, Lindgren S Tags: Clin Res Hepatol Gastroenterol Source Type: research

Continuous Subcutaneous Insulin Infusion versus Multiple daily Insulin Injections in Patients with Type 1 Diabetes Mellitus who Fast during Ramadan: A Systematic Review and Meta-analysis.
CONCLUSIONS: Studies assessing the effect of CSII or MDI in patients with T1DM who fast during Ramadan are limited to observational studies and show no difference in the change in HbA1c, weight or lipids during Ramadan. PMID: 30825561 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 27, 2019 Category: Research Authors: Gad H, Al-Muhannadi H, Mussleman P, Malik RA Tags: Diabetes Res Clin Pract Source Type: research

CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.
CONCLUSIONS: CD110 promotes pancreatic cancer progression and it may serve as a predictive factor for liver metastasis. PMID: 30770989 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 15, 2019 Category: Research Authors: Yan Z, Ohuchida K, Zheng B, Okumura T, Takesue S, Nakayama H, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M Tags: J Cancer Res Clin Oncol Source Type: research

Gastrointestinal function in dementia with Lewy bodies: a comparison with Parkinson disease.
CONCLUSION: Gastric emptying was prolonged in dementia with Lewy bodies compared to Parkinson disease. PMID: 30741396 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - February 11, 2019 Category: Research Authors: Doi H, Sakakibara R, Masuda M, Tateno F, Aiba Y, Kishi M, Yamanishi T, Yamamoto T, Matsuoka K Tags: Clin Auton Res Source Type: research

Investigation of a Dipeptidyl Peptidase-4 Inhibitor/Thiazolidinedione Combination Drug for Patients With Type 2 Diabetes and Poor Glycemic Control: Difficulty With Patient Enrollment.
Conclusions: It was confirmed that the combination of DPP4I with PG was effective for the treatment of type 2 DM and improving metabolic function. Our data also showed that prescription of antidiabetic drugs differed between specialties, suggesting differences in their response to the results of various clinical studies and adverse reaction reports. PMID: 30701000 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Okamura K, Shirai K, Miyazaki M, Okuda T, Takamiya Y, Goto M, Urata H Tags: J Clin Med Res Source Type: research

Cytoskeletal Tropomyosin as a Biomarker in Clostridium difficile Infection.
Conclusion: Tpm has a potential role as a CDI biomarker in combination with C. difficile PCR and an appropriate clinical evaluation. However, non-muscle Tpm, as a biomarker for CDI, suffers from a low sensitivity in our study. Therefore further investigation using larger cohorts is needed. PMID: 30701001 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Usacheva EA, Peterson LR, Mendoza K, Schora DM, Hossain MM, Jin JP Tags: J Clin Med Res Source Type: research

Bleeding Complications in Warfarin-Treated Patients Admitted to the Emergency Department.
Conclusions: While the parameters evaluated in this study did not significantly differ among warfarin-treated patients, they may nonetheless pose a risk of bleeding. Further large-scale and long-term studies that take into account biological variation are required to precisely identify the risk factors for bleeding. PMID: 30701002 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Ozturk M, Ipekci A, Kiyak SK, Akdeniz YS, Aydin Y, Ikizceli I, Sogut O Tags: J Clin Med Res Source Type: research

Assessment of Salivary Nitric Oxide Levels in Elite University Athletes in Japan: Findings From a Cross Sectional Study Design.
Abstract Background: High-intensity exercise affects the level of salivary nitric oxide (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide species. However, in athletes with high-intensity training, the relationship between salivary NO levels and oxidative stress is yet to be clear. Additionally, the association of salivary NO levels and the common health disorders of athletes is unknown. Thus, the aim of this cross-sectional study was to clarify the relationship between salivary NO levels and oxidative stress, and the health/medical disorders existing in elite class university athletes. ...
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Sone R, Matsuba K, Tahara R, Eda N, Kosaki K, Jesmin S, Miyakawa S, Watanabe K Tags: J Clin Med Res Source Type: research

To Use or Not to Use Opioid Analgesia for Acute Abdominal Pain Before Definitive Surgical Diagnosis? A Systematic Review and Network Meta-Analysis.
Conclusions: Any type of opioid analgesic can be used safely for acute abdominal pain without risk of impairment of diagnostic accuracy. PMID: 30701004 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Gavriilidis P, de'Angelis N, Tobias A Tags: J Clin Med Res Source Type: research

Effect of Troponin I Elevation on Duration of Mechanical Ventilation and Length of Intensive Care Unit Stay in Patients With Sepsis.
Conclusions: Troponin elevation was associated with longer duration of mechanical ventilation in patients admitted to ICU with sepsis. Troponin elevation was associated with higher risk for development of septic shock. No significant effect was observed in ICU length of stay and hospital length of stay. PMID: 30701005 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Abdalla M, Sohal S, Al-Azzam B, Mohamed W Tags: J Clin Med Res Source Type: research

The Gonadotropin-Releasing Hormone Analogue Therapy May Not Impact Final Height in Precocious Puberty of Girls With Onset of Puberty Aged 6 - 8 Years.
Conclusions: GnRHa therapy did not make a positive contribution to final height in precocious puberty of girls with onset of puberty aged 6 - 8 years. PMID: 30701006 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Korkmaz O, Sari G, Mecidov I, Ozen S, Goksen D, Darcan S Tags: J Clin Med Res Source Type: research

Factors Influencing the Results in Matrix-Associated Autologous Chondrocyte Implantation: A 2 - 5 Year Follow-Up Study.
Conclusions: The MACI application provides good and stable outcomes for focal cartilage damage in young patients. In order to obtain significant results after autologous chondrocyte implantation, the selection of appropriate patients without concomitant pathologies is required. PMID: 30701007 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Gursoy S, Akkaya M, Simsek ME, Gursoy M, Dogan M, Bozkurt M Tags: J Clin Med Res Source Type: research

Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia.
Abstract Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by both a myeloproliferative neoplasm and a myelodysplastic syndrome. This malignancy often infiltrates various extramedullary organs and has a poor prognosis. An 84-year-old Japanese man with CMML was suffered from hemoptysis and dyspnea. When he arrived at the emergency room, hemoptysis stopped. ...
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Tanaka H, Yano M, Kuwabara C, Kume A, Tamura Y, Murakami M, Shimizu R, Saito H, Suzuki Y Tags: J Clin Med Res Source Type: research

Does Metformin Assist New Anti-Diabetic Drugs to Succeed?
PMID: 30701009 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - February 1, 2019 Category: Research Authors: Kastuyama H, Yanai H Tags: J Clin Med Res Source Type: research

Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma.
CONCLUSION: Our studies support the concept of circulating plEVs as a tool for non-invasive diagnosis and monitoring of gliomas, and should move this field closer to the goal of improving the management of cancer patients. PMID: 30679164 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 24, 2019 Category: Research Authors: Indira Chandran V, Welinder C, Månsson AS, Offer S, Freyhult E, Pernemalm M, Lund SM, Pedersen S, Lehtiö J, Marko-Varga G, Johansson MC, Englund EM, Sundgren PC, Belting M Tags: Clin Cancer Res Source Type: research

The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
CONCLUSIONS: PMID: 30670494 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 22, 2019 Category: Research Authors: Digomann D, Kurth I, Tyutyunnykova A, Chen O, Löck S, Gorodetska I, Peitzsch C, Skvortsova I, Negro G, Aschenbrenner B, Eisenhofer G, Richter S, Heiden S, Porrmann J, Klink B, Schwager C, Dowle AA, Hein L, Kunz-Schughart LA, Abdollahi A, Lohaus F, Krause Tags: Clin Cancer Res Source Type: research

Plasma omentin levels are associated with vascular endothelial function in patients with type 2 diabetes at elevated cardiovascular risk.
This study aimed to investigate the association between omentin and vascular endothelial function in patients with type 2 diabetes (T2D). METHODS: The subjects were 425 patients with T2D and 223 non-diabetic controls. Fasting plasma omentin levels were measured by enzyme-linked immunosorbent assay, and the endothelium-dependent, flow-mediated dilatation (FMD) was measured by ultrasonography. RESULTS: Plasma omentin levels were higher, while FMD was lower in participants with T2D than in non-diabetic controls. No significant correlation was found between plasma omentin levels and FMD in either non-diabetic control...
Source: Clin Med Res - January 11, 2019 Category: Research Authors: Hayashi M, Morioka T, Hatamori M, Kakutani Y, Yamazaki Y, Kurajoh M, Motoyama K, Mori K, Fukumoto S, Shioi A, Shoji T, Emoto M, Inaba M Tags: Diabetes Res Clin Pract Source Type: research

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.
CONCLUSIONS: IGFBP2 protects EAC cells against ABS-induced DNA damage and apoptosis through stabilization and activation of EGFR - DNA-PKcs signaling axis. PMID: 30626422 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - January 9, 2019 Category: Research Authors: Zhou Z, Lu H, Zhu S, Gomaa A, Chen Z, Yan J, Washington K, El-Rifai W, Dang C, Peng D Tags: J Exp Clin Cancer Res Source Type: research

High frequency of H3 K27M mutations in adult midline gliomas.
CONCLUSION: H3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors. PMID: 30610375 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - January 4, 2019 Category: Research Authors: Ebrahimi A, Skardelly M, Schuhmann MU, Ebinger M, Reuss D, Neumann M, Tabatabai G, Kohlhof-Meinecke P, Schittenhelm J Tags: J Cancer Res Clin Oncol Source Type: research

Malignant anomalous origin of circumflex artery in an elite athlete.
Abstract PMID: 30560380 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 17, 2018 Category: Research Authors: Most AK, Bauer T, Nef H, Hamm C, Bauer P Tags: Clin Res Cardiol Source Type: research

Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Conclusion Although there was some encouraging efficacy signal, grade 4 neutropenia led to complications and it was decided to stop the study. A DL below 5 mg/m2/day was not tested as this would not allow reaching the minimum serum concentration needed for the pharmacological activity of the drug. PMID: 30547316 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 14, 2018 Category: Research Authors: Leary A, Le Tourneau C, Varga A, Sablin MP, Gomez-Roca C, Guilbaud N, Petain A, Pavlyuk M, Delord JP Tags: Invest New Drugs Source Type: research

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.
CONCLUSIONS: Gynecologic cancer radiotherapy patients want to discuss sexual health, but report suboptimal provider inquiry. Patient views and experiences varied based on marital status, education level, and FSFI score. This work highlights the need for improved sexual health communication between cancer patients and providers. PMID: 30539283 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 11, 2018 Category: Research Authors: Chapman CH, Heath G, Fairchild P, Berger MB, Wittmann D, Uppal S, Tolpadi A, Maturen K, Jolly S Tags: J Cancer Res Clin Oncol Source Type: research

Contrast-free, echocardiography-guided left atrial appendage occlusion (LAAo): a propensity-matched comparison with conventional LAAo using the AMPLATZER ™ Amulet™ device.
In this study, we aimed to assess feasibility and safety of contrast-free, 3D-echo-based LAAo with the use of the AMPLATZER™ Amulet™ device. METHODS AND RESULTS: We analyzed 20 patients (74 ± 10 years, 65% males) at an increased thromboembolic and bleeding risk (CHA2DS2VASC 4.0 ± 1.3; HAS-BLED 3.5 ± 0.9) with chronic renal failure (GFR 41 ± 21 ml/min) undergoing LAAo without the use of contrast dye at our center and compared the results with a propensity-matched cohort (1:1 matching) of conventionally treated patients ...
Source: Clin Med Res - December 10, 2018 Category: Research Authors: Sedaghat A, Al-Kassou B, Vij V, Nelles D, Stuhr M, Schueler R, Omran H, Schrickel JW, Hammerstingl C, Nickenig G Tags: Clin Res Cardiol Source Type: research

Genetic Variants Associated with Vincristine-Induced Peripheral Neuropathy in Two Populations of Children with Acute Lymphoblastic Leukemia.
This article is protected by copyright. All rights reserved. PMID: 30506673 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - December 3, 2018 Category: Research Authors: Li L, Sajdyk T, Smith EML, Chang CW, Li C, Ho RH, Hutchinson R, Wells E, Skiles JL, Winick N, Renbarger JL Tags: Clin Pharmacol Ther Source Type: research

Biovigilance for the Quality and Safety of Medical Products of Human Origin.
Abstract Progress in science and technology in the health services has led to the development of methods of regenerating and replacing solid organs, tissues and cells, using human body components to create medical products of human origin intended for clinical use. In the activities in which products of human origin are used, however, from the point of donation and harvesting to the subsequent care of the recipient, medical products of human origin are exposed to the risk of specific complications related to the transmission of infectious diseases, and further side-effects. Biovigilance system application is a bas...
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Gkioka V, Tsirigotis P, Sarris M, Soulis S, Apostolou A, Noutsias M, Dimitriadis G, Kostakis A, Boletis I, Karabinis A Tags: J Clin Med Res Source Type: research

The Effects of Geography on Outcomes of Routine Early Versus Selective Late Revascularization Strategy in the Treatment of Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Transatlantic Randomized Controlled Trials.
Abstract Background: The optimal timing of revascularization in unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI) remains uncertain. We compared routine early revascularization (REV) versus selective late revascularization (SLR) strategies and divergence in the approach of cardiologists in the United States and Europe. Methods: Seventeen randomized controlled trials (RCTs) (15,812 patients) were extracted from PubMed, Cochrane Library, EMBASE and Web of Science databases. The data were pooled using the Der Simonian and Laird random-effect models and expressed as pooled risk ratio...
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Virk HUH, Lo KB, Krittanawong C, Inayat F, Sarwar U, Ghani AR, Witzke C, Janzer S, George JC, Pressman G, Bozorgnia B, Chatterjee S, Figueredo VM Tags: J Clin Med Res Source Type: research

Present Status and Perspectives on Future Roles of Japanese Clinical Research Coordinators.
Conclusion: The present study revealed that about half of the clinical research coordinators and other clinical research-related personnel view a broadening of involvement of clinical research coordinators in research activities positively. Accordingly, a structured practical program aimed at encouraging such involvement may help to expand and strengthen their contribution into the future. Whether greater involvement of clinical research coordinators in clinical research will help to ensure the reliability of investigator-initiated clinical research warrants further study. PMID: 30425759 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Yanagawa H, Nokihara H, Yokoi H, Houchi H, Nagai M, Yamashita R, Suganuma N, Hyodo M, Shikoku Collaborative Group for Promotion of Clinical Trials Tags: J Clin Med Res Source Type: research

Clinical Usefulness of the Cardio-Ankle Vascular Index as a Predictor of Primary Cardiovascular Events in Patients With Chronic Kidney Disease.
Abstract Background: The cardio-ankle vascular index (CAVI) is a physiologic marker reflecting arterial function. There have been no prospective studies investigating the relationship between CAVI and cardiovascular events in patients with chronic kidney disease (CKD). The aim of this prospective study was to assess the clinical usefulness of CAVI as a predictor of primary cardiovascular events in patients with CKD. Methods: The study enrolled 460 outpatients with CKD but no history of cardiovascular disease (152 men and 308 women; mean ± standard deviation age, 74 ± 12 years). Patients were ass...
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Hitsumoto T Tags: J Clin Med Res Source Type: research

Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible.
Conclusion: Despite the availability of appropriate antibiotics, MPP incurs significant mortality and morbidity. Our study indicated that the recommended treatment includes prompt serological diagnosis, aggressive supportive care and presumptive antibiotics, especially in patients with poor prognosis. PMID: 30425761 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Bajantri B, Toolsie O, Venkatram S, Diaz-Fuentes G Tags: J Clin Med Res Source Type: research

APACHE II Death Risk and Length of Stay in the ICU Are Associated With Pressure Injury in Critically Ill Patients.
Abstract Background: The aim of this study was to identify factors associated with pressure injury (PI) occurrence in critically ill patients. This was a retrospective cohort study conducted at a mixed intensive care unit (ICU). Methods: Univariate analysis and logistic regression were used to identify which variables are associated with PI. Results: Twenty-one (15%) of 142 patients developed PI. The median and the range of the variables in the groups without and with PI were as follows: Braden scale risk score, 13 (8 - 20) and 10 (8 - 14) points, respectively; Acute Physiology and Chronic Health Evaluat...
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Gulin FS, Menegueti MG, Auxiliadora-Martins M, de Araujo TR, Bellissimo-Rodrigues F, Nassiff A, Basile-Filho A, Laus AM Tags: J Clin Med Res Source Type: research

Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome.
Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS. Methods: We retrospectively reviewed 102 reproductive-aged women who visited the Department of Gynecology, Kyoto Medical Center in Japan from January 2...
Source: Clin Med Res - November 16, 2018 Category: Research Authors: Minato S, Sakane N, Kotani K, Nirengi S, Hayashi I, Suganuma A, Yamaguchi K, Takakura K, Nagai N Tags: J Clin Med Res Source Type: research