Multiple social roles in early adulthood and later mental health in different labour market contexts
Adv Life Course Res. 2021 Dec;50:100432. doi: 10.1016/j.alcr.2021.100432. Epub 2021 Jun 25.ABSTRACTWork and family roles entail divergent responsibilities, which can be a source of conflict especially in young adulthood - the so-called "rush-hour" of life. Combining these multiple social roles can result in an accumulation of stress but also be a valuable resource for mental health. The aim of this study is to investigate combined employment, parenthood and partnership trajectories of men and women during early adulthood, and to analyse the relationship of these multiple roles with depressive symptoms at older ag...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Miriam Engels Morten Wahrendorf Nico Dragano Anne McMunn Christian Deindl Source Type: research

Reducing indoor particle exposure using mobile air purifiers-Experimental and numerical analysis
AIP Adv. 2021 Dec 9;11(12):125114. doi: 10.1063/5.0064805. eCollection 2021 Dec.ABSTRACTAerosol particles are one of the main routes of transmission of COVID-19. Mobile air purifiers are used to reduce the risk of infection indoors. We focus on an air purifier that generates a defined volumetric air flow through a highly efficient filter material. We investigate the transport of aerosol particles from an infected dummy equipped with an aerosol generator to receiving thermal dummies. For analysis, we use up to 12 particle sensors to monitor the particle concentration with high spatial resolution. Based on the measurement da...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Adrian Tobisch Lukas Springsklee Lisa-Franziska Sch äfer Nico Sussmann Martin J Lehmann Frederik Weis Raoul Z öllner Jennifer Niessner Source Type: research

Scattering < em > versus < /em > fluorescence self-quenching: more than a question of faith for the quantification of water flux in large unilamellar vesicles?
Nanoscale Adv. 2021 Oct 18;4(1):58-76. doi: 10.1039/d1na00577d. eCollection 2021 Dec 21.ABSTRACTThe endeavors to understand the determinants of water permeation through membrane channels, the effect of the lipid or polymer membrane on channel function, the development of specific water flow inhibitors, the design of artificial water channels and aquaporins for the use in industrial water filtration applications all rely on accurate ways to quantify water permeabilities (P f). A commonly used method is to reconstitute membrane channels into large unilamellar vesicles (LUVs) and to subject these vesicles to an osmotic gradie...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Johann Wachlmayr Christof Hannesschlaeger Armin Speletz Thomas Barta Anna Eckerstorfer Christine Siligan Andreas Horner Source Type: research

Listening to your mass spectrometer: An open-source toolkit to visualize mass spectrometer data
DISCUSSION: We have developed a customizable web-based dashboard for instrument performance monitoring for our opiate confirmation LC-MS/MS assay using data collected with each batch. The web-based platform allows users to monitor instrument performance and can encompass other instruments throughout the laboratory. This information can help the laboratory take proactive measures to maintain instruments, ultimately reducing the amount down time needed for maintenance.PMID:35028636 | PMC:PMC8739458 | DOI:10.1016/j.jmsacl.2021.12.003 (Source: Adv Data)
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Abed Pablo Andrew N Hoofnagle Patrick C Mathias Source Type: research

Triple combination of BET plus PI3K and NF- κB inhibitors exhibit synergistic activity in adult T cell leukemia/lymphoma
Blood Adv. 2022 Jan 14:bloodadvances.2021005948. doi: 10.1182/bloodadvances.2021005948. Online ahead of print.ABSTRACTAdult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell lymphoproliferative malignancy, caused by human T-cell leukemia virus type 1 (HTLV-1). ATL is an orphan disease with no curative drug treatment regimens, urgently needing new combination therapy. HTLV-1-infected cells rely on viral proteins, Tax and HBZ (HTLV-1-b-ZIP factor), to activate the transcription of various host genes that are critical for promoting leukemic transformation. Inhibition of bromodomain and extra-terminal motif (BET) protein ...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Anusara Daenthanasanmak Richard N Bamford Makoto Yoshioka Shyh-Ming Yang Philip John Homan Baktiar Karim Bonita R Bryant Michael N Petrus Craig Thomas Patrick L Green Milos D Miljkovic Kevin C Conlon Thomas A Waldmann Source Type: research

Regenerating Islet-Derived 3-alpha is a Prognostic Biomarker for Gastrointestinal Chronic Graft-Versus-Host Disease
Blood Adv. 2022 Jan 14:bloodadvances.2021005420. doi: 10.1182/bloodadvances.2021005420. Online ahead of print.ABSTRACTPrognostic biomarkers used to identify likelihood of disease progression have not been identified for chronic graft-versus-host disease (cGVHD), the leading cause of late non-relapse mortality (NRM) in survivors of allogenic hematopoietic cell transplantation. Gastrointestinal cGVHD (GI-cGVHD) has been particularly challenging to classify. Here, we analyzed three proteomics markers [Regenerating-islet-derived-3-alpha (Reg3α), C-X-C-motif-ligand (CXCL9) and Stimulation-2 (ST2)] in two independent cohor...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Brittany Paige DePriest Hong Li Alan Bidgoli Lynn Onstad Daniel R Couriel Stephanie J Lee Sophie Paczesny Source Type: research

Indirect Comparison of Tisagenlecleucel and Historical Treatments for Relapsed/Refractory Diffuse Large B-cell Lymphoma
This study indirectly compared the overall survival (OS) and overall response rate (ORR) associated with tisagenlecleucel, using data from the JULIET study (NCT02445248), versus historical treatments assessed in the CORAL study follow-up population. To assess treatment effects in the treated (full analysis set [FAS]) and enrolled (intent-to-treat [ITT]) study populations, the JULIET FAS vs. the CORAL follow-up FAS and JULIET ITT vs. CORAL follow-up ITT populations were separately compared. Propensity score weighting using standardized mortality ratio weight (SMRW) and fine stratification weight (FSW) was used to compare OS...
Source: Adv Data - January 14, 2022 Category: Epidemiology Authors: Richard T Maziarz Jie Zhang Hongbo Yang Xinglei Chai Chengbo Yuan Elisabeth Schwarz Mihael Jakovac Marcela Martinez-Prieto Abhijit Agarwal Evgeny Degtyarev Constantine S Tam Gilles Andre Salles Source Type: research

Cerebral Critical Closing Pressure in Concomitant Traumatic Brain Injury and Intracranial Hematomas
Adv Exp Med Biol. 2021;1339:33-38. doi: 10.1007/978-3-030-78787-5_5.ABSTRACTThe critical closing pressure (CrCP) is the pressure below which the local pial blood pressure is inadequate to prevent blood flow cessation. The cerebral CrCP in concomitant traumatic brain injury (TBI) and intracranial hematomas (TBI + ICH) remains understudied. The aim was to determine the status of the CrCP at сTBI with and without the ICH development.MATERIAL AND METHODS: The results of the treatment of 90 patients with severe to moderate сTBI were studied (male/female - 49:41). The average age was 34.2 ± 14.4 years. Depending on the ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Kseniia A Trofimova Darya I Agarkova Alex O Trofimov Andrew Y Abashkin Denis E Bragin Source Type: research

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neurodegenerative Diseases
Adv Exp Med Biol. 2021;1339:51-58. doi: 10.1007/978-3-030-78787-5_8.ABSTRACTAging is responsible for homeostatic dysregulation and the primary risk for neurodegenerative diseases. The main signaling pathways may regulate inflammatory-related disorders and neurodegeneration include genomic instability, cell senescence, and mitochondria dysfunction. The use of high-throughput technologies has emerged as a powerful approach to the rapid discovery of many candidate biomarkers for age-related diseases. Various types of molecules, such as nucleic acids, proteins, or metabolites, can serve as soluble factors in clinical practice ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Marios G Krokidis Source Type: research

Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia
Adv Exp Med Biol. 2021;1339:121-129. doi: 10.1007/978-3-030-78787-5_17.ABSTRACTHeart rate variability (HRV) represents one of the two key markers of the autonomic nervous system. It is measured by the time variation in the beat-to-beat interval, while the period between successive beats is defined as the RR interval (RRI). Its components are classified as linear and non-linear. In the field of psychophysiology, HRV is investigated as a key player of possible predictive or diagnostic value. Female adolescents with general learning disabilities or dyslexia were recruited at the Center for Adolescent Medicine and UNESCO Chair...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Geronikolou S Flora Bacopoulou Stavros Chryssanthopoulos John Koutelekos George I Lambrou Dennis Cokkinos Source Type: research

Synthesis and Biological Evaluation of Substituted Thiophene Derivatives
Adv Exp Med Biol. 2021;1339:179-185. doi: 10.1007/978-3-030-78787-5_23.ABSTRACTA novel series of pyrazolines were synthesized by cycloaddition of various chalcones (prepared by a Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl thiophene and various aromatic aldehydes) with the phenyl hydrazines in the presence of pyridine and subjected to molecular property prediction by Molinspiration, MolSoft, and Osiris software. The structures of new compounds were established by 1HNMR, IR, and mass spectral data. Most of the synthesized compounds (1A-E) were found to be in conformity with Lipinski's "rule of five" and ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Naveena Palupanuri Swathi Konda Lavanya Sara B Nikitha Source Type: research

Genetic Pathways Involved in the Pathogenesis of Parkinson's Disease
Adv Exp Med Biol. 2021;1339:195-208. doi: 10.1007/978-3-030-78787-5_25.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease. PD pathogenesis includes both genetic and environmental factors. Previous studies have linked the disease with several genes such as Parkin, SNCA, PINK1 and HTRA2. BiNGO software utilizes GO annotations in order to detect over-represented genes in terms of biological processes, cellular components and molecular functions. Three databases were utilized for this study (Ensembl, DisGeNET and UniProt). Data processing provided 110 genes associated with PD for further analy...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Konstantina Skolariki Marios Diamantopoulos Panayiotis Vlamos Source Type: research

The Impact of Exercising in the Quality of Life of People with Dementia-Alzheimer's Disease
Conclusions: The majority of researches seem to converge to the aspect that the physical activity offers considerable benefits to the people suffering from the Alzheimer's disease or any other kind of dementia. More specifically, it contributes to the stability and the improvement of mental function as well as to the delay of the appearance of serious neuropsychiatric symptoms such as depression, confusion, and apathy. Moreover, the role of physical activity is significant in the improvement of functional ability of patients suffering from dementia resulting in the enforcement of autonomy in everyday activities and the con...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Mavridis Dimities Florou Xristina Kountani Theodora-Elesa Chania Maria Source Type: research

Clinical and Molecular Study of Common Thrombophilia Mutation Prothrombin G20210A
CONCLUSIONS: This study highlighted the great value of a positive family history of thrombosis and the importance of testing for this common mutation as a putative prevention strategy and a future biomarker for thrombophilia.PMID:35023122 | DOI:10.1007/978-3-030-78787-5_40 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Antonia Angelopoulou Dimitrios Vlachakis George P Chrousos Nikolaos Cosmidis Christos Yapijakis Source Type: research

Skin Mirrors Brain: A Chance for Alzheimer's Disease Research
Adv Exp Med Biol. 2021;1339:371-380. doi: 10.1007/978-3-030-78787-5_45.ABSTRACTThe accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age-associated pathological conditions in the entire body. Apparently based on the fact that the nervous system and skin share a common ectodermal origin, certain genes and molecular pathways associated with the pathomechanism of neurodegenerative diseases modify their expression with progressing skin ag...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Christos C Zouboulis Evgenia Makrantonaki Amir M Hossini Source Type: research

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision
Adv Exp Med Biol. 2021;1339:395-402. doi: 10.1007/978-3-030-78787-5_49.ABSTRACTPrecision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Medicine however is not an agnostic collection of all manner of clinical, genetic and other biologic data in select cohorts. This is an important point. Sim...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Dimitrios Avramopoulos Dimitrios Kapogiannis Jeannie-Marie Leoutsakos Constantine G Lyketsos Vasiliki Mahairaki Milap Nowrangi Kenichi Oishi Esther S Oh Paul B Rosenberg Quincy Samus Gwenn S Smith Kenneth Witwer Sevil Yasar Peter P Zandi Source Type: research

Circular Polarized Light Emission in Chiral Inorganic Nanomaterials
This article is protected by copyright. All rights reserved.PMID:35023219 | DOI:10.1002/adma.202108431 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shuang Jiang Nicholas A Kotov Source Type: research

Magnetic Domain Confined Printing of Programmable Organic Microcrystal Assemblies for Information Encryption
This article is protected by copyright. All rights reserved.PMID:35023586 | DOI:10.1002/adma.202108279 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Baipeng Yin Hao Jia Rui Chen Qingda Chang Jiangang Feng Hanfei Gao Yuchen Wu Lei Jiang Chuang Zhang Source Type: research

Self-Directed Learning During the COVID-19 Pandemic: Perspectives of South African Final-Year Health Professions Students
CONCLUSION: The importance of SDL as a skill for uncertain times warrants further investigation in the training of future healthcare professionals. Inclusive planning and engagement with final-year health professions students to address identified stressors, as well as the creation of shared platforms where students are part of the decision-making processes for clinical learning and training are recommended. Responsive curricula that optimize unpredictable disruptions in clinical training are needed to equip students to diagnose their own learning needs and implement appropriate learning strategies.PMID:35023986 | PMC:PMC8...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Veena S Singaram Kimesh L Naidoo Shenuka Singh Source Type: research

Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity
CONCLUSION: Neomenthol delayed the growth of skin carcinoma cells by inhibiting the tubulin polymerization and hyaluronidase activity, which are responsible for tumor growth, metastasis, and angiogenesis.PMID:35024183 | PMC:PMC8655237 | DOI:10.1016/j.jare.2021.06.003 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Kaneez Fatima Nusrat Masood Zahoor Ahmad Wani Abha Meena Suaib Luqman Source Type: research

< em > Erythrina velutina < /em > Willd. alkaloids: Piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves
CONCLUSION: Overall, these results could contribute by indicating potential biotechnological targets for modulation of erythrina alkaloids biosynthesis as well as improve molecular databases with omic data from a non-model medicinal plant, and reveal an interesting chemical diversity of Erythrina BIA harvested in Caatinga.PMID:35024185 | PMC:PMC8655131 | DOI:10.1016/j.jare.2021.01.017 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Daisy Sotero Chacon Taffarel Melo Torres Ivanice Bezerra da Silva Thiago Ferreira de Ara újo Alan de Ara újo Roque Francisco Ayrton Senna Domingos Pinheiro Denise Selegato Alan Pilon Fernanda Priscila Santos Reginaldo Cibele Tesser da Costa Johnatan Vil Source Type: research

Derivation of "Egyptian varices prediction (EVP) index": A novel noninvasive index for diagnosing esophageal varices in HCV Patients
CONCLUSION: EVP Index was a good noninvasive predictor. It had an acceptable performance for diagnosing EVs and it was only required regular laboratory tests and imaging data. It can provide a tool for classifying or arranging the patients according to the degree pre-emptive for selective endoscopy and the degree of severity. Also, it will enable clinicians to concentrate on one marker instead of a wide set of parameters.PMID:35024195 | PMC:PMC8721354 | DOI:10.1016/j.jare.2021.02.005 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shimaa M Abd-Elsalam Mohamed M Ezz Shehab Gamalel-Din Gamal Esmat Wafaa Elakel Mahmoud ElHefnawi Source Type: research

An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study
CONCLUSION: These results suggest that a microbiota profile is associated to the T2DM development. An integrate predictive model of microbiome and clinical data that can improve the prediction of T2DM is also proposed, if is validated in independent populations to prevent this disease.PMID:35024196 | PMC:PMC8721255 | DOI:10.1016/j.jare.2021.05.001 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Cristina Vals-Delgado Juan F Alcala-Diaz Helena Molina-Abril Irene Roncero-Ramos Martien P M Caspers Frank H J Schuren Tim J Van den Broek Raul Luque Pablo Perez-Martinez Niki Katsiki Javier Delgado-Lista Jose M Ordovas Ben van Ommen Antonio Camargo Jose Source Type: research

Create laboratory business intelligence dashboards for free using R: A tutorial using the flexdashboard package
J Mass Spectrom Adv Clin Lab. 2021 Dec 13;23:39-43. doi: 10.1016/j.jmsacl.2021.12.002. eCollection 2022 Jan.ABSTRACTThis tutorial described use of the R flexdashboard package and its possibilities for customization to develop a dashboard to monitor critical result reporting in a clinical laboratory. Several examples of interactive components were demonstrated. Sample code and exercises were provided to facilitate learning.PMID:35024687 | PMC:PMC8732779 | DOI:10.1016/j.jmsacl.2021.12.002 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shannon Haymond Source Type: research

Real-World Treatment Patterns and Clinical Outcomes for Standard of Care Regimens in Patients with Deficient MMR or MSI-High Metastatic Colorectal and Non-Colorectal Cancer: A Retrospective Chart Review Study in France
CONCLUSION: Real-world clinical outcomes observed for patients with dMMR/MSI-H mCRC receiving 3L treatment(s) are suboptimal, suggesting a high unmet need that could be addressed with ICIs.PMID:35025060 | DOI:10.1007/s12325-021-01956-8 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Montserrat Roset Mayur Amonkar Renna Patel N úria Lara Smita Kothari Source Type: research

Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium
Adv Exp Med Biol. 2022 Jan 14. doi: 10.1007/5584_2021_702. Online ahead of print.ABSTRACTThe role of parvovirus B19 (PVB19) in the pathogenesis of idiopathic dilated cardiomyopathy (DCM) remains poorly understood. Therefore, we have measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies (EMBs) and sera of nonischemic PVB19-positive (n = 14) and PVB19-negative (n = 18) DCM patients. Chronic persistence of PVB19 in myocardium did not induce significant infiltration of T cells (CD3 and CD45Ro) and macrophages (CD68), and did not secrete TNFα, IL-6, and CRB. The fibrosis in PVB1...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Daiva Bironait ė Ieva Ka žukauskienė Julius Bogomolovas Dainius Daunoravi čius Art ūras Jakubauskas Dalius Vitkus Edvardas Žurauskas K ęstutis Ručinskas Siegfried Labeit Virginija Grabauskiene Source Type: research

Validation and clinical application of transactivation assays for RUNX1 variant classification
Blood Adv. 2022 Jan 13:bloodadvances.2021006161. doi: 10.1182/bloodadvances.2021006161. Online ahead of print.ABSTRACTFamilial platelet disorder with associated myeloid malignancies (RUNX1-FPD) is caused by heterozygous pathogenic germline variants of RUNX1. In the present study, we evaluate the applicability of transactivation assays to investigate RUNX1 variants in different regions of the protein. We studied 11 variants to independently validate transactivation assays supporting variant classification following the ClinGen Myeloid Malignancies variant curation expert panel guidelines. Variant classification is key for t...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Melanie Decker Anupriya Agarwal Andreas Benneche Jane E Churpek Nicolas Duployez Adam DuVall Martijn P T Ernst Alisa F örster Hildegunn H øberg Vetti Michelle Nash Marc H G P Raaijmakers Tor Henrik Anderson Tvedt Adrianna Vlachos Brigitte Schlegelberger Source Type: research

Cerebral Critical Closing Pressure in Concomitant Traumatic Brain Injury and Intracranial Hematomas
Adv Exp Med Biol. 2021;1339:33-38. doi: 10.1007/978-3-030-78787-5_5.ABSTRACTThe critical closing pressure (CrCP) is the pressure below which the local pial blood pressure is inadequate to prevent blood flow cessation. The cerebral CrCP in concomitant traumatic brain injury (TBI) and intracranial hematomas (TBI + ICH) remains understudied. The aim was to determine the status of the CrCP at сTBI with and without the ICH development.MATERIAL AND METHODS: The results of the treatment of 90 patients with severe to moderate сTBI were studied (male/female - 49:41). The average age was 34.2 ± 14.4 years. Depending on the ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Kseniia A Trofimova Darya I Agarkova Alex O Trofimov Andrew Y Abashkin Denis E Bragin Source Type: research

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neurodegenerative Diseases
Adv Exp Med Biol. 2021;1339:51-58. doi: 10.1007/978-3-030-78787-5_8.ABSTRACTAging is responsible for homeostatic dysregulation and the primary risk for neurodegenerative diseases. The main signaling pathways may regulate inflammatory-related disorders and neurodegeneration include genomic instability, cell senescence, and mitochondria dysfunction. The use of high-throughput technologies has emerged as a powerful approach to the rapid discovery of many candidate biomarkers for age-related diseases. Various types of molecules, such as nucleic acids, proteins, or metabolites, can serve as soluble factors in clinical practice ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Marios G Krokidis Source Type: research

Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia
Adv Exp Med Biol. 2021;1339:121-129. doi: 10.1007/978-3-030-78787-5_17.ABSTRACTHeart rate variability (HRV) represents one of the two key markers of the autonomic nervous system. It is measured by the time variation in the beat-to-beat interval, while the period between successive beats is defined as the RR interval (RRI). Its components are classified as linear and non-linear. In the field of psychophysiology, HRV is investigated as a key player of possible predictive or diagnostic value. Female adolescents with general learning disabilities or dyslexia were recruited at the Center for Adolescent Medicine and UNESCO Chair...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Geronikolou S Flora Bacopoulou Stavros Chryssanthopoulos John Koutelekos George I Lambrou Dennis Cokkinos Source Type: research

Synthesis and Biological Evaluation of Substituted Thiophene Derivatives
Adv Exp Med Biol. 2021;1339:179-185. doi: 10.1007/978-3-030-78787-5_23.ABSTRACTA novel series of pyrazolines were synthesized by cycloaddition of various chalcones (prepared by a Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl thiophene and various aromatic aldehydes) with the phenyl hydrazines in the presence of pyridine and subjected to molecular property prediction by Molinspiration, MolSoft, and Osiris software. The structures of new compounds were established by 1HNMR, IR, and mass spectral data. Most of the synthesized compounds (1A-E) were found to be in conformity with Lipinski's "rule of five" and ...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Naveena Palupanuri Swathi Konda Lavanya Sara B Nikitha Source Type: research

Genetic Pathways Involved in the Pathogenesis of Parkinson's Disease
Adv Exp Med Biol. 2021;1339:195-208. doi: 10.1007/978-3-030-78787-5_25.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease. PD pathogenesis includes both genetic and environmental factors. Previous studies have linked the disease with several genes such as Parkin, SNCA, PINK1 and HTRA2. BiNGO software utilizes GO annotations in order to detect over-represented genes in terms of biological processes, cellular components and molecular functions. Three databases were utilized for this study (Ensembl, DisGeNET and UniProt). Data processing provided 110 genes associated with PD for further analy...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Konstantina Skolariki Marios Diamantopoulos Panayiotis Vlamos Source Type: research

The Impact of Exercising in the Quality of Life of People with Dementia-Alzheimer's Disease
Conclusions: The majority of researches seem to converge to the aspect that the physical activity offers considerable benefits to the people suffering from the Alzheimer's disease or any other kind of dementia. More specifically, it contributes to the stability and the improvement of mental function as well as to the delay of the appearance of serious neuropsychiatric symptoms such as depression, confusion, and apathy. Moreover, the role of physical activity is significant in the improvement of functional ability of patients suffering from dementia resulting in the enforcement of autonomy in everyday activities and the con...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Mavridis Dimities Florou Xristina Kountani Theodora-Elesa Chania Maria Source Type: research

Clinical and Molecular Study of Common Thrombophilia Mutation Prothrombin G20210A
CONCLUSIONS: This study highlighted the great value of a positive family history of thrombosis and the importance of testing for this common mutation as a putative prevention strategy and a future biomarker for thrombophilia.PMID:35023122 | DOI:10.1007/978-3-030-78787-5_40 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Antonia Angelopoulou Dimitrios Vlachakis George P Chrousos Nikolaos Cosmidis Christos Yapijakis Source Type: research

Skin Mirrors Brain: A Chance for Alzheimer's Disease Research
Adv Exp Med Biol. 2021;1339:371-380. doi: 10.1007/978-3-030-78787-5_45.ABSTRACTThe accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age-associated pathological conditions in the entire body. Apparently based on the fact that the nervous system and skin share a common ectodermal origin, certain genes and molecular pathways associated with the pathomechanism of neurodegenerative diseases modify their expression with progressing skin ag...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Christos C Zouboulis Evgenia Makrantonaki Amir M Hossini Source Type: research

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision
Adv Exp Med Biol. 2021;1339:395-402. doi: 10.1007/978-3-030-78787-5_49.ABSTRACTPrecision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Medicine however is not an agnostic collection of all manner of clinical, genetic and other biologic data in select cohorts. This is an important point. Sim...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Dimitrios Avramopoulos Dimitrios Kapogiannis Jeannie-Marie Leoutsakos Constantine G Lyketsos Vasiliki Mahairaki Milap Nowrangi Kenichi Oishi Esther S Oh Paul B Rosenberg Quincy Samus Gwenn S Smith Kenneth Witwer Sevil Yasar Peter P Zandi Source Type: research

Circular Polarized Light Emission in Chiral Inorganic Nanomaterials
This article is protected by copyright. All rights reserved.PMID:35023219 | DOI:10.1002/adma.202108431 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shuang Jiang Nicholas A Kotov Source Type: research

Magnetic Domain Confined Printing of Programmable Organic Microcrystal Assemblies for Information Encryption
This article is protected by copyright. All rights reserved.PMID:35023586 | DOI:10.1002/adma.202108279 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Baipeng Yin Hao Jia Rui Chen Qingda Chang Jiangang Feng Hanfei Gao Yuchen Wu Lei Jiang Chuang Zhang Source Type: research

Self-Directed Learning During the COVID-19 Pandemic: Perspectives of South African Final-Year Health Professions Students
CONCLUSION: The importance of SDL as a skill for uncertain times warrants further investigation in the training of future healthcare professionals. Inclusive planning and engagement with final-year health professions students to address identified stressors, as well as the creation of shared platforms where students are part of the decision-making processes for clinical learning and training are recommended. Responsive curricula that optimize unpredictable disruptions in clinical training are needed to equip students to diagnose their own learning needs and implement appropriate learning strategies.PMID:35023986 | PMC:PMC8...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Veena S Singaram Kimesh L Naidoo Shenuka Singh Source Type: research

Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity
CONCLUSION: Neomenthol delayed the growth of skin carcinoma cells by inhibiting the tubulin polymerization and hyaluronidase activity, which are responsible for tumor growth, metastasis, and angiogenesis.PMID:35024183 | PMC:PMC8655237 | DOI:10.1016/j.jare.2021.06.003 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Kaneez Fatima Nusrat Masood Zahoor Ahmad Wani Abha Meena Suaib Luqman Source Type: research

< em > Erythrina velutina < /em > Willd. alkaloids: Piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves
CONCLUSION: Overall, these results could contribute by indicating potential biotechnological targets for modulation of erythrina alkaloids biosynthesis as well as improve molecular databases with omic data from a non-model medicinal plant, and reveal an interesting chemical diversity of Erythrina BIA harvested in Caatinga.PMID:35024185 | PMC:PMC8655131 | DOI:10.1016/j.jare.2021.01.017 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Daisy Sotero Chacon Taffarel Melo Torres Ivanice Bezerra da Silva Thiago Ferreira de Ara újo Alan de Ara újo Roque Francisco Ayrton Senna Domingos Pinheiro Denise Selegato Alan Pilon Fernanda Priscila Santos Reginaldo Cibele Tesser da Costa Johnatan Vil Source Type: research

Derivation of "Egyptian varices prediction (EVP) index": A novel noninvasive index for diagnosing esophageal varices in HCV Patients
CONCLUSION: EVP Index was a good noninvasive predictor. It had an acceptable performance for diagnosing EVs and it was only required regular laboratory tests and imaging data. It can provide a tool for classifying or arranging the patients according to the degree pre-emptive for selective endoscopy and the degree of severity. Also, it will enable clinicians to concentrate on one marker instead of a wide set of parameters.PMID:35024195 | PMC:PMC8721354 | DOI:10.1016/j.jare.2021.02.005 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shimaa M Abd-Elsalam Mohamed M Ezz Shehab Gamalel-Din Gamal Esmat Wafaa Elakel Mahmoud ElHefnawi Source Type: research

An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study
CONCLUSION: These results suggest that a microbiota profile is associated to the T2DM development. An integrate predictive model of microbiome and clinical data that can improve the prediction of T2DM is also proposed, if is validated in independent populations to prevent this disease.PMID:35024196 | PMC:PMC8721255 | DOI:10.1016/j.jare.2021.05.001 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Cristina Vals-Delgado Juan F Alcala-Diaz Helena Molina-Abril Irene Roncero-Ramos Martien P M Caspers Frank H J Schuren Tim J Van den Broek Raul Luque Pablo Perez-Martinez Niki Katsiki Javier Delgado-Lista Jose M Ordovas Ben van Ommen Antonio Camargo Jose Source Type: research

Create laboratory business intelligence dashboards for free using R: A tutorial using the flexdashboard package
J Mass Spectrom Adv Clin Lab. 2021 Dec 13;23:39-43. doi: 10.1016/j.jmsacl.2021.12.002. eCollection 2022 Jan.ABSTRACTThis tutorial described use of the R flexdashboard package and its possibilities for customization to develop a dashboard to monitor critical result reporting in a clinical laboratory. Several examples of interactive components were demonstrated. Sample code and exercises were provided to facilitate learning.PMID:35024687 | PMC:PMC8732779 | DOI:10.1016/j.jmsacl.2021.12.002 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Shannon Haymond Source Type: research

Real-World Treatment Patterns and Clinical Outcomes for Standard of Care Regimens in Patients with Deficient MMR or MSI-High Metastatic Colorectal and Non-Colorectal Cancer: A Retrospective Chart Review Study in France
CONCLUSION: Real-world clinical outcomes observed for patients with dMMR/MSI-H mCRC receiving 3L treatment(s) are suboptimal, suggesting a high unmet need that could be addressed with ICIs.PMID:35025060 | DOI:10.1007/s12325-021-01956-8 (Source: Adv Data)
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Montserrat Roset Mayur Amonkar Renna Patel N úria Lara Smita Kothari Source Type: research

Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium
Adv Exp Med Biol. 2022 Jan 14. doi: 10.1007/5584_2021_702. Online ahead of print.ABSTRACTThe role of parvovirus B19 (PVB19) in the pathogenesis of idiopathic dilated cardiomyopathy (DCM) remains poorly understood. Therefore, we have measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies (EMBs) and sera of nonischemic PVB19-positive (n = 14) and PVB19-negative (n = 18) DCM patients. Chronic persistence of PVB19 in myocardium did not induce significant infiltration of T cells (CD3 and CD45Ro) and macrophages (CD68), and did not secrete TNFα, IL-6, and CRB. The fibrosis in PVB1...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Daiva Bironait ė Ieva Ka žukauskienė Julius Bogomolovas Dainius Daunoravi čius Art ūras Jakubauskas Dalius Vitkus Edvardas Žurauskas K ęstutis Ručinskas Siegfried Labeit Virginija Grabauskiene Source Type: research

Validation and clinical application of transactivation assays for RUNX1 variant classification
Blood Adv. 2022 Jan 13:bloodadvances.2021006161. doi: 10.1182/bloodadvances.2021006161. Online ahead of print.ABSTRACTFamilial platelet disorder with associated myeloid malignancies (RUNX1-FPD) is caused by heterozygous pathogenic germline variants of RUNX1. In the present study, we evaluate the applicability of transactivation assays to investigate RUNX1 variants in different regions of the protein. We studied 11 variants to independently validate transactivation assays supporting variant classification following the ClinGen Myeloid Malignancies variant curation expert panel guidelines. Variant classification is key for t...
Source: Adv Data - January 13, 2022 Category: Epidemiology Authors: Melanie Decker Anupriya Agarwal Andreas Benneche Jane E Churpek Nicolas Duployez Adam DuVall Martijn P T Ernst Alisa F örster Hildegunn H øberg Vetti Michelle Nash Marc H G P Raaijmakers Tor Henrik Anderson Tvedt Adrianna Vlachos Brigitte Schlegelberger Source Type: research

Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
In this study we investigated and characterized the molecular and pathogenic mechanisms through which a novel cysteine variant p.(Cys1084Tyr) causes an unusual, mixed phenotype form of von Willebrand disease (VWD). Phenotypic data including bleeding scores, laboratory values, VWF multimer distribution and desmopressin response kinetics were investigated in 5 members (2 parents and 3 daughters) of a consanguineous family. VWF synthesis and secretion were also assessed in a heterologous expression system and in a transient transgenic mouse model. Heterozygosity for p.(Cys1084Tyr) was associated with variable expressivity of ...
Source: Adv Data - January 12, 2022 Category: Epidemiology Authors: Orla Rawley Laura L Swystun Christine Brown Kate Nesbitt Margaret L Rand Taneya Hossain Robert Klaassen Paula D James Manuel Carcao David Lillicrap Source Type: research

Results of a UK real world study of polatuzumab vedotin, bendamustine, and rituximab for relapsed/refractory large B-cell lymphoma
Blood Adv. 2022 Jan 12:bloodadvances.2021005953. doi: 10.1182/bloodadvances.2021005953. Online ahead of print.ABSTRACTThe addition of polatuzumab vedotin to bendamustine and rituximab (Pola-BR) has been shown to improve overall survival (OS) in stem cell transplant (SCT)-ineligible patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). It is also increasingly used as bridging to CAR T-cell therapy (CAR-T). We retrospectively analysed the efficacy of Pola-BR in 133 patients at 28 UK institutions. Treatment intent was bridging to CAR-T for N=40, re-induction with planned SCT for N=13 and stand-alone t...
Source: Adv Data - January 12, 2022 Category: Epidemiology Authors: Michael Northend William Wilson Wendy Osborne Christopher P Fox Andrew John Davies Dima El-Sharkawi Elizabeth H Phillips Hau Wui Sim Shalal Sadullah Nimish Shah Ying Ying Peng Iman Qureshi Juanah Addada Rocio Figueroa Mora Neil Phillips Andrea Kuhnl Eliza Source Type: research

Sidelined during COVID-19: a narrative inquiry into how simulationists experienced the pandemic
CONCLUSIONS: The findings reflect a snapshot in time of how simulation was viewed and used in the world during a pandemic through the personal stories of simulationists with clinical backgrounds who did not provide direct patient care. Sharing these narratives may inform future simulation development; however, it is vitally important that the emotions are recognized and acknowledged. Managers should ensure mental health resources and support are available to all staff, including those not deployed to the frontline.PMID:35012689 | PMC:PMC8744035 | DOI:10.1186/s41077-021-00196-8 (Source: Adv Data)
Source: Adv Data - January 11, 2022 Category: Epidemiology Authors: Kim Leighton Suzan Kardong-Edgren Anna Jones Gabriel Reedy Source Type: research