Ureases: Historical aspects, catalytic, and non-catalytic properties - A review.
Abstract Urease (urea amidohydrolase, EC 220.127.116.11) is a nickel-containing enzyme produced by plants, fungi, and bacteria that catalyzes the hydrolysis of urea into ammonia and carbamate. Urease is of historical importance in Biochemistry as it was the first enzyme ever to be crystallized (1926). Finding nickel in urease's active site (1975) was the first indication of a biological role for this metal. In this review, historical and structural features, kinetics aspects, activation of the metallocenter and inhibitors of the urea hydrolyzing activity of ureases are discussed. The review also deals with the non-enzyma...
Source: Adv Data - August 12, 2018 Category: Epidemiology Authors: Kappaun K, Piovesan AR, Carlini CR, Ligabue-Braun R Tags: J Adv Res Source Type: research
Direct oral anticoagulants for stroke prevention in atrial fibrillation: treatment outcomes and dosing in special populations.
CONCLUSIONS: Overall, results of secondary analyses indicate that the recommended dosing strategy for each of the DOACs produces a consistent anticoagulant effect across a diverse patient population, including those at increased risk of stroke or bleeding. PMID: 30081727 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - August 9, 2018 Category: Epidemiology Authors: Stacy ZA, Richter SK Tags: Ther Adv Cardiovasc Dis Source Type: research
Seasonal and spatial dynamics of enteric viruses in wastewater and in riverine and estuarine receiving waters.
In this study we used carefully validated methods to monitor enteric viruses, namely adenovirus (AdV), JC polyomavirus (JCV), noroviruses (NoVs), sapovirus (SaV) and hepatitis A and E viruses (HAV and HEV) from wastewater source to beaches and shellfish beds. Wastewater influent and effluent, surface water, sediment and shellfish samples were collected in the Conwy catchment (North Wales, UK) once a month for one year. High concentrations of AdV and JCV were found in the majority of samples, and no seasonal patterns were observed. No HAV and HEV were detected and no related illnesses were reported in the area during the pe...
Source: Adv Data - June 16, 2018 Category: Epidemiology Authors: Farkas K, Cooper DM, McDonald JE, Malham SK, de Rougemont A, Jones DL Tags: Sci Total Environ Source Type: research
Five-year outcome and predictors of success after second-generation cryoballoon ablation for treatment of symptomatic atrial fibrillation.
CONCLUSIONS: Sinus rhythm was maintained in a substantial proportion of patients even 5 years after CB-Adv ablation. Patients with a non-enlarged left atrium without diabetes had the best outcome. PMID: 29887425 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - June 13, 2018 Category: Epidemiology Authors: Akkaya E, Berkowitsch A, Zaltsberg S, Greiss H, Hamm CW, Sperzel J, Kuniss M, Neumann T Tags: Int J Cardiol Source Type: research
The NURSING-Positive Recruitment Arabic Model (NURS-P.R.A.M.): A Mixed Methods Study.
CONCLUSION: The study findings reflect certain issues similar to the core international literature on nursing recruitment, however there are fundamental issues particular to the Arab region, which must be included in the development of a nursing recruitment strategy for Arabic nursing. This article is protected by copyright. All rights reserved. PMID: 29893428 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Tawash E, Cowman S Tags: J Adv Nurs Source Type: research
Person-centred pain management for the patient with acute abdominal pain: an ethnography informed by the Fundamentals of Care framework.
CONCLUSIONS: Person-centred pain management requires an organization where patients and practitioners share their knowledge of pain and pain management as true partners. Leaders and practitioners should make small behavioural changes to enable the crucial positive experience of pain management. This article is protected by copyright. All rights reserved. PMID: 29893491 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Avallin T, Muntlin Athlin Å, Sorensen EE, Kitson A, Björck M, Jangland E Tags: J Adv Nurs Source Type: research
The effect of preparation strategies, qualification and professional background on clinical nurse educator confidence.
CONCLUSIONS: This study identifies several preparation strategies that significantly enhance clinical educator confidence and readiness for their complex role. These preparation strategies drawn from the Vietnamese context, provide important examples for the wider nursing community to consider. This article is protected by copyright. All rights reserved. PMID: 29893505 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Nguyen VNB, Forbes H, Mohebbi M, Duke M Tags: J Adv Nurs Source Type: research
Utilization of initial chemotherapy for newly diagnosed acute myeloid leukemia in the United States.
Abstract The use of chemotherapy in patients with acute myeloid leukemia (AML) is associated with survival benefits and alleviation of symptoms related to AML. Prior studies have demonstrated a lower receipt of chemotherapy with increasing age and comorbidities. We hypothesized that socioeconomic and health system factors also determine the use of chemotherapy. We included 61 775 adults with AML diagnosed between 2003 and 2011 from the National Cancer Database, and performed a multivariable logistic regression model to determine the association between receipt of chemotherapy and several factors. A total of...
Source: Adv Data - June 9, 2018 Category: Epidemiology Authors: Bhatt VR, Shostrom V, Gundabolu K, Armitage JO Tags: Blood Adv Source Type: research
Safety and immunogenicity of conjugate quadrivalent meningococcal vaccination after hematopoietic cell transplantation.
Abstract Immunization with the conjugated quadrivalent (serogroups A, C, Y, and W-135) meningococcal vaccine (MCV4) after hematopoietic cell transplantation (HCT) is recommended. However, immune responses to MCV4 have not been prospectively studied after HCT. We conducted a vaccine response study among 67 adults who received 1 MCV4 dose a year after autologous or allogeneic HCT from January to September 2014. Pre- and postvaccination serogroup serum bactericidal antibody (SBA) titers were measured a median of 57 days after vaccination. Serogroup-specific responses were defined as a fourfold increase in SBA titer w...
Source: Adv Data - June 8, 2018 Category: Epidemiology Authors: Cheng MP, Pandit A, Antin JH, Walsh SR, Huynh D, Ghobrial IM, Baden LR, Marty FM, Issa NC Tags: Blood Adv Source Type: research
In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL.
Abstract Despite the addition of tyrosine kinase inhibitors (TKIs) to the treatment of patients with BCR-ABL1+ B-cell precursor acute lymphoblastic leukemia (BCR-ABL1+ BCP-ALL), relapse both with and without BCR-ABL1 mutations is a persistent clinical problem. To identify BCR-ABL1-independent genetic mediators of response to the TKI dasatinib, we performed in vivo and in vitro RNA interference (RNAi) screens in a transplantable syngeneic mouse model of BCR-ABL1+ BCP-ALL. By using a novel combination of a longitudinal screen design and independent component analysis of screening data, we identified hairpins that ha...
Source: Adv Data - June 3, 2018 Category: Epidemiology Authors: Fiedler ERC, Bhutkar A, Lawler E, Besada R, Hemann MT Tags: Blood Adv Source Type: research
Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita.
Abstract Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome and the prototypic telomere biology disorder (TBD). Leukocyte telomere length (TL) less than the first percentile for age, measured by flow cytometry with in situ hybridization (flow FISH), is diagnostic of DC. Androgens are a therapeutic option for DC/TBD-associated bone marrow failure (BMF). One report has shown an apparent increase in TL in patients while on treatment with the attenuated androgen danazol. The aim of this study was to compare TL over time in 10 androgen-treated and 16 untreated patients with DC. All subjects were e...
Source: Adv Data - June 3, 2018 Category: Epidemiology Authors: Khincha PP, Bertuch AA, Gadalla SM, Giri N, Alter BP, Savage SA Tags: Blood Adv Source Type: research
Related donor transplants: has posttransplantation cyclophosphamide nullified the detrimental effect of HLA mismatch?
Leukemia Working Party of the European Society for Blood and Marrow Transplant and the Center for International Blood and Marrow Transplant Research Abstract We sought to identify whether posttransplantation cyclophosphamide (PT-Cy) reduces or eliminates the detrimental impact of HLA mismatching on outcomes of HLA-haploidentical related donor transplantation for acute leukemia. Data from 2143 donor-recipient pairs (n = 218 haploidentical sibling; n = 218 offspring; n = 1707 HLA-matched sibling) with acute myeloid or lymphoblastic leukemia were studied. All received a calcineurin inhibitor for graft-versus-host dis...
Source: Adv Data - May 30, 2018 Category: Epidemiology Authors: Robinson TM, Fuchs EJ, Zhang MJ, St Martin A, Labopin M, Keesler DA, Blaise D, Bashey A, Bourhis JH, Ciceri F, Ciurea SO, Devine SM, Mohty M, McCurdy SR, Milpied N, McNiece IK, Rocha V, Romee R, Socie G, Yakoub-Agha I, Soiffer RJ, Eapen M, Nagler A, Acute Tags: Blood Adv Source Type: research
Identification of patients with hemoglobin SS/S β0 thalassemia disease and pain crises within electronic health records.
This study demonstrates the feasibility to accurately identify patients with specific types of SCD and pain crises within an EHR. PMID: 29792312 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - May 26, 2018 Category: Epidemiology Authors: Singh A, Mora J, Panepinto JA Tags: Blood Adv Source Type: research
Prevalence and Analysis of Medical Device-Related Pressure Injuries: Results from the International Pressure Ulcer Prevalence Survey.
This study is a retrospective analysis of the 2016 International Pressure Ulcer Prevalence data. Data were limited to US and Canadian facilities. Facilities included acute care, long-term care, rehabilitation, long-term acute care hospitals, and hospice. Analysis included 102,865 adult patients; 99,876 had complete data and were the focus of the analysis and are reported in the results below. RESULTS: The overall PI prevalence was 7.2% (n = 7189), and the facility-acquired prevalence was 3.1% (n = 3113). The prevalence of MDR PIs was 0.60% (n = 601), which included both mucosal and nonmucosal MDR PIs. In this study, 7...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Kayser SA, VanGilder CA, Ayello EA, Lachenbruch C Tags: Adv Skin Wound Care Source Type: research
NGSPanPipe: A Pipeline for Pan-genome Identification in Microbial Strains from Experimental Reads.
Abstract Recent advancements in sequencing technologies have decreased both time span and cost for sequencing the whole bacterial genome. High-throughput Next-Generation Sequencing (NGS) technology has led to the generation of enormous data concerning microbial populations publically available across various repositories. As a consequence, it has become possible to study and compare the genomes of different bacterial strains within a species or genus in terms of evolution, ecology and diversity. Studying the pan-genome provides insights into deciphering microevolution, global composition and diversity in virulence...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Kulsum U, Kapil A, Singh H, Kaur P Tags: Adv Exp Med Biol Source Type: research
Characterization and Antimicrobial Property of Some Heavy Metals Containing Ayurvedic Drugs.
Abstract Ayurvedic medicines are often used in different formulations, the heavy metals, which are generally referred to as being toxic. In this work, we report on the physicochemical characterization and biological activity of some typical Ayurvedic drugs available in the market that contain arsenic, mercury and lead with the emphasis on their antibacterial performance. Among the formulations studied, some of the drugs with 'amorphous' texture (and higher solubility) were found quite active against some bacterial strains whereas the formulations possessing crystalline texture (and low solubility) were found pract...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Panta P, Bhandari TR, Lamsal B, Adhikari R Tags: Adv Exp Med Biol Source Type: research
Health Perception and Adherence with Blood Pressure Control among Rural Chinese Adults with Hypertension.
CONCLUSION: These findings suggest: (a) healthcare providers should focus on educating rural hypertensive adults about healthful diets and behaviors to manage hypertension, especially for those with high household income; (b) knowledge-based health education alone is not adequate; (c) illness perception may not be directly associated with blood pressure and; (d) the Chinese Illness-Perception Questionnaire-Revised and the Inventory of Adherence to Self-management require validation and potential revision for use with rural Chinese populations. This article is protected by copyright. All rights reserved. PMID: 29788548...
Source: Adv Data - May 22, 2018 Category: Epidemiology Authors: Yang L, Taylor E, Winslow B, Pothier P Tags: J Adv Nurs Source Type: research
The characteristics of vessel lining cells in normal spleens and their role in the pathobiology of myelofibrosis.
Abstract The CD34-CD8α+, sinusoid lining, littoral cells (LCs), and CD34+CD8α-, splenic vascular endothelial cells (SVECs) represent 2 distinct cellular types that line the vessels within normal spleens and those of patients with myelofibrosis (MF). To further understand the respective roles of LCs and SVECs, each was purified from normal and MF spleens, cultured, and characterized. Gene expression profiling indicated that LCs were a specialized type of SVEC. LCs possessed a distinct gene expression profile associated with cytoskeleton regulation, cellular interactions, endocytosis, and iron transport....
Source: Adv Data - May 20, 2018 Category: Epidemiology Authors: Qiu J, Salama ME, Hu CS, Li Y, Wang X, Hoffman R Tags: Blood Adv Source Type: research
Epidemiology of AL amyloidosis: a real-world study using US claims data.
This study aimed to provide an up-to-date estimate of prevalence and incidence of AL amyloidosis in the United States. Using claims databases from years 2007 to 2015, adults ≥18 years old with AL amyloidosis were included if they had (1) at least 1 inpatient or 2 outpatient claims consistent with AL amyloidosis and (2) received 1 AL-specific treatment. Prevalence was calculated as the number of AL patients divided by the number of enrollees on June 30th of each calendar year. Incidence was calculated as the number of patients with AL who were disease-free and enrolled with a health plan for 1 year prior, divided by the ...
Source: Adv Data - May 13, 2018 Category: Epidemiology Authors: Quock TP, Yan T, Chang E, Guthrie S, Broder MS Tags: Blood Adv Source Type: research
Analysis of the thrombotic and fibrinolytic activities of tumor cell-derived extracellular vesicles.
Abstract Exosomes and microvesicles (MVs) are small extracellular vesicles secreted by tumor cells and are suggested to contribute to the thrombotic events that commonly occur in patients with advanced malignancies. Paradoxically, these vesicles have been reported to also possess fibrinolytic activity. To determine whether thrombotic or fibrinolytic activity is a predominant characteristic of these extracellular vesicles, we prepared exosomes and MVs from 2 breast cancer cell lines (MDA-MB-231 and MCF7), a lung cancer cell line (A549), and a leukemia cell line (NB4) and assayed their thrombotic and fibrinolytic ac...
Source: Adv Data - May 13, 2018 Category: Epidemiology Authors: Durrieu L, Bharadwaj A, Waisman DM Tags: Blood Adv Source Type: research
Second-generation cryoballoon ablation as a first-line treatment of symptomatic atrial fibrillation: Two-year outcome and predictors of recurrence after a single procedure.
CONCLUSION: This is the first demonstration that PVI with CB-Adv is safe and effective as a first-line treatment of symptomatic AF. Sinus rhythm persisted in 79.2% of patients even 2years after ablation. The success rate was lower in patients with enlarged left atria. PMID: 29579615 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - March 28, 2018 Category: Epidemiology Authors: Akkaya E, Berkowitsch A, Zaltsberg S, Greiss H, Hamm CW, Sperzel J, Neumann T, Kuniss M Tags: Int J Cardiol Source Type: research
In-situ magnetization/heating electron holography to study the magnetic ordering in arrays of nickel metallic nanowires.
Abstract Magnetic nanostructures of different size, shape, and composition possess a great potential to improve current technologies like data storage and electromagnetic sensing. In thin ferromagnetic nanowires, their magnetization behavior is dominated by the competition between magnetocrystalline anisotropy (related to the crystalline structure) and shape anisotropy. In this way electron diffraction methods like precession electron diffraction (PED) can be used to link the magnetic behavior observed by Electron Holography (EH) with its crystallinity. Using off-axis electron holography under Lorentz conditions, ...
Source: Adv Data - January 30, 2018 Category: Epidemiology Authors: Ortega E, Santiago U, Giuliani JG, Monton C, Ponce A Tags: AIP Adv Source Type: research
3D Printing of Materials with Tunable Failure via Bioinspired Mechanical Gradients.
Abstract Mechanical gradients are useful to reduce strain mismatches in heterogeneous materials and thus prevent premature failure of devices in a wide range of applications. While complex graded designs are a hallmark of biological materials, gradients in manmade materials are often limited to 1D profiles due to the lack of adequate fabrication tools. Here, a multimaterial 3D-printing platform is developed to fabricate elastomer gradients spanning three orders of magnitude in elastic modulus and used to investigate the role of various bioinspired gradient designs on the local and global mechanical behavior of syn...
Source: Adv Data - January 16, 2018 Category: Epidemiology Authors: Kokkinis D, Bouville F, Studart AR Tags: Adv Mater Source Type: research
First-time detection of porcine reproductive and respiratory syndrome virus (PRRSV) infection in Uruguay.
Abstract Within the last two decades, several high-impact viruses have emerged in the global swine population, including porcine reproductive and respiratory syndrome virus (PRRSV). In Uruguay, the more recent serological survey for PRRSV and other notifiable diseases such as Aujeszky's disease virus (ADV) and classical swine fever virus (CSFV) dated from year 2000. The main purpose of this study was to update our information on the infection status of PRRSV, ADV and CSFV in Uruguayan pig herds, in order to keep informed about the epidemiological situation of these notifiable infections in the country. For serolog...
Source: Adv Data - January 12, 2018 Category: Epidemiology Authors: Ramos N, Mirazo S, Castro G, Cabrera K, Osorio F, Arbiza J Tags: Transbound Emerg Dis Source Type: research
Thioether-Polyglycidol as Multivalent and Multifunctional Coating System for Gold Nanoparticles.
Abstract Thiofunctional polymers are the established standard for the coating and biofunctionalization of gold nanoparticles (AuNPs). However, the nucleophilic and oxidative character of thiols provokes polymeric crosslinking and significantly limits the chemical possibilities to introduce biological functions. Thioethers represent a chemically more stable potential alternative to thiols that would offer easier functionalization, yet a few studies in the literature report inconclusive data regarding the efficacy of thioethers to stabilize AuNPs in comparison to thiols. A systematic comparison is presented of mono-...
Source: Adv Data - January 10, 2018 Category: Epidemiology Authors: Feineis S, Lutz J, Heffele L, Endl E, Albrecht K, Groll J Tags: Adv Mater Source Type: research
Laparoscopic Versus Open Adrenalectomy for Localized/Locally Advanced Primary Adrenocortical Carcinoma (ENSAT I-III) in Adults: Is Margin-Free (R0) Resection the Key Surgical Factor that Dictates Outcome?-A Review of the Literature.
CONCLUSIONS: LA appears to be equivalent to open method for localized/locally advanced primary ACC (ENSAT I-III) in terms of R0 resection rate, overall recurrence, DFS, and OS, therefore suggesting that the extent of surgery with adequate tumor resection is the predominant endpoint, rather than the surgical approach itself. Multicenter randomized controlled trials with long follow-up time periods exploring the long-term oncological outcomes are required to determine the benefits of the laparoscopic over the open approach in adrenocortical carcinoma. PMID: 29319399 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - January 10, 2018 Category: Epidemiology Authors: Mpaili E, Moris D, Tsilimigras DI, Oikonomou D, Pawlik TM, Schizas D, Papalampros A, Felekouras E, Dimitroulis D Tags: J Laparoendosc Adv Surg Tech A Source Type: research
Laypersons Knowledge and Perceptions of Irritable Bowel Syndrome as Potential Barriers to Care.
CONCLUSION: Laypersons have an understanding of the symptoms associated with Irritable Bowel Syndrome; however, hold numerous misconceptions regarding the aetiology, role of the healthcare provider, necessary testing and risks associated with Irritable Bowel Syndrome. These misconceptions are inconsistent with current guidelines and practices. Establishing partnerships and educating social networks in addition to patients may enhance outcomes for those with Irritable Bowel Syndrome. This article is protected by copyright. All rights reserved. PMID: 29319900 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - January 10, 2018 Category: Epidemiology Authors: Sherwin LB Tags: J Adv Nurs Source Type: research
Treatment Dosing Patterns and Clinical Outcomes for Patients with Type 2 Diabetes Starting or Switching to Treatment with Insulin Glargine (300 Units per Milliliter) in a Real-World Setting: A Retrospective Observational Study.
This study evaluated differences in dosing and clinical outcomes before and after Gla-300 treatment initiation in patients with type 2 diabetes starting or switching to treatment with Gla-300 to assess whether the benefits observed in clinical trials translate into real-world settings. METHODS: This was a retrospective observational study using medical record data obtained by physician survey for patients starting treatment with insulin glargine at a strength of 100 units per milliliter (Gla-100) or Gla-300, or switching to treatment with Gla-300 from treatment with another basal insulin (BI). Differences in dosing an...
Source: Adv Data - January 8, 2018 Category: Epidemiology Authors: Gupta S, Wang H, Skolnik N, Tong L, Liebert RM, Lee LK, Stella P, Cali A, Preblick R Tags: Adv Ther Source Type: research
Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life.
Abstract INTRODUCTION: Directly recorded patient experience of symptoms and health-related quality of life (HRQoL) can complement lung function and exacerbation rate data in chronic obstructive pulmonary disease (COPD) clinical studies. The FULFIL study recorded daily symptoms and activity limitation together with additional patient-reported outcomes of dyspnea and HRQoL, as part of the prespecified analyses. FULFIL co-primary endpoint data have been previously reported. METHODS: FULFIL was a phase III, 24-week, randomized, double-blind, double-dummy, multicenter study comparing once-daily single inhaler trip...
Source: Adv Data - January 8, 2018 Category: Epidemiology Authors: Tabberer M, Lomas DA, Birk R, Brealey N, Zhu CQ, Pascoe S, Locantore N, Lipson DA Tags: Adv Ther Source Type: research
Feasibility of Robotic-Assisted Transabdominal Preperitoneal Ventral Hernia Repair.
CONCLUSIONS: Our study results support the safe and effective placement of mesh in the preperitoneal space via the use of robotic technology, and they represent the largest single-surgeon series of robotic-assisted TAPP ventral hernia repair. Large, multicenter prospective trials could further elucidate the potential benefits and the long-term outcomes from this approach. PMID: 29293068 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - January 2, 2018 Category: Epidemiology Authors: Orthopoulos G, Kudsi OY Tags: J Laparoendosc Adv Surg Tech A Source Type: research
Diagnostic Laparoscopy for Trauma: How Not to Miss Injuries.
CONCLUSIONS: DL is a feasible and safe procedure. It accurately identifies intraabdominal injuries. The selected use of preoperative imaging, adherence to the predetermined steps of procedure and the standard systematic laparoscopic examination will minimize the rate of missed injuries. PMID: 29293406 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - January 2, 2018 Category: Epidemiology Authors: Koto MZ, Matsevych OY, Aldous C Tags: J Laparoendosc Adv Surg Tech A Source Type: research
An autumn tale: geriatric rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive arthritis and systemic organ involvement. The disease may affect all ages and both sexes; usually it is seen in young women aged 25-45. Recent studies have shown that RA is among the most common inflammatory disease in older age groups. While elderly-onset rheumatoid arthritis (EORA) is still discussed in the literature, it is generally accepted as a disease beginning after 65 years of age. Compared with young-onset rheumatoid arthritis (YORA), it was found that EORA had different characteristics. EORA is characterized by...
Source: Adv Data - January 1, 2018 Category: Epidemiology Authors: Kobak S, Bes C Tags: Ther Adv Musculoskelet Dis Source Type: research
Small-angle X-ray scattering tensor tomography: model of the three-dimensional reciprocal-space map, reconstruction algorithm and angular sampling requirements.
This article presents a reconstruction of the complete reciprocal-space map for the case of bone over extended ranges of q. In addition, it is shown that uniform angular sampling and advanced regularization strategies help to reduce the amount of data required. PMID: 29269594 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - December 24, 2017 Category: Epidemiology Authors: Liebi M, Georgiadis M, Kohlbrecher J, Holler M, Raabe J, Usov I, Menzel A, Schneider P, Bunk O, Guizar-Sicairos M Tags: Acta Crystallogr A Found Adv Source Type: research
Improving the convergence rate of a hybrid input-output phasing algorithm by varying the reflection data weight.
Abstract In an iterative projection algorithm proposed for ab initio phasing, the error metrics typically exhibit little improvement until a sharp decrease takes place as the iteration converges to the correct high-resolution structure. Related to that is the small convergence probability for certain structures. As a remedy, a variable weighting scheme on the diffraction data is proposed. It focuses on phasing low- and medium-resolution data first. The weighting shifts to incorporate more high-resolution reflections when the iteration proceeds. It is found that the precipitous drop in error metrics is replaced by ...
Source: Adv Data - December 24, 2017 Category: Epidemiology Authors: He H, Su WP Tags: Acta Crystallogr A Found Adv Source Type: research
Multislice imaging of integrated circuits by precession X-ray ptychography.
In this study, tilt-series ptychographic diffraction data sets of a two-layered circuit with a ∼1.4 µm gap at nine incident angles are collected in a wide Q range and then artifact-reduced phase images of each layer are successfully reconstructed at ∼10 nm resolution. The present method has great potential for the three-dimensional observation of flat specimens with thickness on the order of 100 µm, such as three-dimensional stacked integrated circuits based on through-silicon vias, without laborious sample preparation. PMID: 29269599 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - December 24, 2017 Category: Epidemiology Authors: Shimomura K, Hirose M, Takahashi Y Tags: Acta Crystallogr A Found Adv Source Type: research
Perspective: interesterified triglycerides, the recent increase in deaths from heart disease, and elevated blood viscosity.
Abstract The authors hypothesize that consumption of interesterified fats may be the cause of the continuous increase in cardiovascular deaths in the United States which began in 2011. Interesterification is a method of producing solid fats from vegetable oil and began to supplant partial hydrogenation for this purpose upon recognition of the danger of trans fats to cardiovascular health. Long, straight carbon chains, as are present in saturated and trans fatty acids, decrease the fluidity of the erythrocyte cell membrane, which decreases erythrocyte deformability and increases blood viscosity. This decrease in ce...
Source: Adv Data - December 23, 2017 Category: Epidemiology Authors: Sloop GD, Weidman JJ, St Cyr JA Tags: Ther Adv Cardiovasc Dis Source Type: research
Infrared Skin Thermometry: Validating and Comparing Techniques to Detect Periwound Skin Infection.
CONCLUSIONS: The results of this study demonstrate that both the 4-point and whole-wound methods of temperature acquisition using cost-efficient infrared thermometers provide accurate and similar results in clinical wound care settings. PMID: 29240589 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - December 16, 2017 Category: Epidemiology Authors: Mufti A, Somayaji R, Coutts P, Sibbald RG Tags: Adv Skin Wound Care Source Type: research
Abstract The pulvinar can be subdivided into well-delimitated regions based on chemoarchitectural, cytoarchitectural, myeloarchitectural, connectivity, and electrophysiological criteria. Subdivisions of the pulvinar based on its chemoarchitectural features are the most consistently preserved across species of New and Old World monkeys. It is reasonable to speculate that the occurrence and distribution of calcium-binding proteins in the pulvinar, such as calbindin and parvalbumin, have been preserved along evolution. Therefore, they have proven to be valuable tools capable of probing the basic pulvinar scaffold acr...
Source: Adv Data - November 10, 2017 Category: Epidemiology Authors: Gattass R, Soares JGM, Lima B Tags: Adv Anat Embryol Cell Biol Source Type: research
Reestablishing the Chemoarchitectural Borders Based on Electrophysiological and Connectivity Data.
Abstract In this chapter, we discuss the poor agreement between visuotopic maps described using electrophysiological and connectivity data and the subdivisions of the pulvinar based on chemoarchitecture. We focus on the differences and similarities between New and Old World monkeys to evaluate how this agreement evolved during evolution. There is some agreement in the localization of P1, described using electrophysiological and connectivity data, and the lateral and central portions of the nucleus pulvinaris inferior (PI), defined based on chemoarchitectural criteria. Similarly, there is some colocalization betwee...
Source: Adv Data - November 10, 2017 Category: Epidemiology Authors: Gattass R, Soares JGM, Lima B Tags: Adv Anat Embryol Cell Biol Source Type: research
Association between the Medical College Admission Test scores and Alpha Omega Alpha Medical Honors Society membership.
Abstract INTRODUCTION: Medical schools worldwide are faced with the challenge of selecting from among many qualified applicants. One factor that might help admissions committees identify future exceptional medical students is scores on standardized entrance exams. The purpose of this study was to determine the association between scores on the most commonly used standardized medical school entrance exam in the USA, the Medical College Admission Test (MCAT), and election to the US medical honors society, Alpha Omega Alpha (AOA). METHOD: MCAT scores and AOA membership data were analyzed for all the students pur...
Source: Adv Data - October 7, 2017 Category: Epidemiology Authors: Gauer JL, Jackson JB Tags: Adv Med Educ Pract Source Type: research
Fertilization 1: Sperm-Egg Interaction.
Abstract In birds in the reproductive season, an egg is ovulated without cumulus cells from the largest follicle with the highest hierarchy in the ovary. The outermost part of the ovulated eggs is the perivitelline layer, a glycoprotein matrix consisting of a few ZP-glycoproteins. The fertilization starts from sperm penetration of the perivitelline layer predominantly in the germinal disc region, followed by uptake of the sperm into the egg, and goes through by the fusion of sperm male pronucleus with the female pronucleus in the egg. A series of these fertilization steps occurs in the infundibulum of the oviduct ...
Source: Adv Data - October 7, 2017 Category: Epidemiology Authors: Nishio S, Matsuda T Tags: Adv Exp Med Biol Source Type: research
Local structure and oxide-ion conduction mechanism in apatite-type lanthanum silicates.
uda K Abstract The local structure of apatite-type lanthanum silicates of general formula La9.33+x(SiO4)6O2+3x/2 has been investigated by combining the atomic pair distribution function (PDF) method, conventional X-ray and neutron powder diffraction (NPD) data and density functional theory (DFT) calculations. DFT was used to build structure models with stable positions of excess oxide ions within the conduction channel. Two stable interstitial positions were obtained in accordance with literature, the first one located at the very periphery of the conduction channel, neighbouring the SiO4 tetrahedral units, and th...
Source: Adv Data - October 5, 2017 Category: Epidemiology Authors: Masson O, Berghout A, Béchade E, Jouin J, Thomas P, Asaka T, Fukuda K Tags: Sci Technol Adv Mater Source Type: research
[The role of interactions of transposons with epigenetic factors in the aging process].
Abstract The review considers modern theories of aging mechanisms and data on epigenetic regulation of ontogenesis. Transposons may be the material bases of the epigenetic control system, their movements affect the differentiation of cells and can cause genomic instability. Control systems aimed at protecting against foreign DNA (splicing machine, microRNA processing) became the basis of regulatory networks of genomes underlying cell differentiation. Transposon sequences are the basis for non-coding RNAs that suppress the expression of the transposons themselves and protein-coding genes at the posttranscriptional ...
Source: Adv Data - October 4, 2017 Category: Epidemiology Authors: Mustafin RN, Khusnutdinova EK Tags: Adv Gerontol Source Type: research
[Features of anthropometric and component indicators of women (75-90 years) of russian nationality in Yakutsk].
Abstract Anthropometric examination of 128 women of russian nationality of senile age (75-90 years) in Yakutsk was carried out. All the examined were born and permanently resided in the territory of Yakutia. Anthropometric measurements were carried out according to the method of V. V. Bunak (1941), body components (the total amount of fat, muscle tissue, bone tissue) were calculated according to the method of J. Matiegka (1921). The resulting material was processed using the variation statistics method. The anthropometric and component indices of russian women of old age in Yakutsk are determined, the characterist...
Source: Adv Data - October 4, 2017 Category: Epidemiology Authors: Alekseyeva VA, Guryeva AB Tags: Adv Gerontol Source Type: research
[Evaluation of the effectiveness and safety of compression hosiery «Mediven Plus» in the treatment of elderly patients with chronic venous diseases of the lower extremities].
[Evaluation of the effectiveness and safety of compression hosiery «Mediven Plus» in the treatment of elderly patients with chronic venous diseases of the lower extremities]. Adv Gerontol. 2017;30(4):570-572 Authors: Katorkin SE, Melnikov MA, Kravtsov PF, Bulgakova SV, Zakharova NO, Nikolaeva AV, Treneva EV Abstract This publication presents the results of a study aimed at assessing the justification of the use of compression hosiery «Mediven Plus» among patients in the older age group on the basis of demographic, anthropometric data (gender, age, weight of the patient; the vol...
Source: Adv Data - October 4, 2017 Category: Epidemiology Authors: Katorkin SE, Melnikov MA, Kravtsov PF, Bulgakova SV, Zakharova NO, Nikolaeva AV, Treneva EV Tags: Adv Gerontol Source Type: research
[Gender-specific manifestations of daily physical activity and sedentary behaviour in elderly people of Surgut].
Abstract Objective of the study was to establish gender-specific characteristics of physical activity (PA) and sedentary behavior in elderly people living in Yugra North. 295 residents of Surgut (102 men aged 62,9±5,3 years, 35%; 193 women aged 61,9±3,8 years, 65%) were subject to a IPAQ-RU questionnaire. The study revealed the gender-specific differences in body length and mass, body mass and body fat indices. It was detected that more energy is spent on the housework and physical activity in the country (moderate-intensity physical activity for women and high-intensity one for men). The study data ...
Source: Adv Data - October 4, 2017 Category: Epidemiology Authors: Loginov SI, Malkov MN, Nikolayev AY Tags: Adv Gerontol Source Type: research
Alemtuzumab in the long-term treatment of relapsing-remitting multiple sclerosis: an update on the clinical trial evidence and data from the real world.
Abstract Alemtuzumab is a humanized monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis (RRMS), given as two annual courses on five consecutive days at baseline and on three consecutive days 12 months later. Here we provide an update on the long-term efficacy and safety of alemtuzumab in RRMS, including real-world experience, and advances in our understanding of its mechanism of action. Recent data from the phase II/III extension study have demonstrated that alemtuzumab reduces relapse rates, disability worsening, and the rate of brain volume loss over the long term, with many ...
Source: Adv Data - October 1, 2017 Category: Epidemiology Authors: Ziemssen T, Thomas K Tags: Ther Adv Neurol Disord Source Type: research
Outcomes in Patients Treated with a Novel, Simple Method for Hemostasis of Dermal Avulsion Injuries.
CONCLUSIONS: This series demonstrates cosmetic outcomes for injuries treated with the technique, highlights potential problems that may be perceived by patients during their clinical course, and creates the groundwork for a larger clinical study examining the use of the technique. PMID: 28914680 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 17, 2017 Category: Epidemiology Authors: Dowling ST, Lin BW Tags: Adv Skin Wound Care Source Type: research
The Correlation Between Biofilm Production and Catheter-Related Bloodstream Infections Sustained by Candida. A Case Control Study.
Abstract Biofilm forming capacity of yeasts colonizing the intravenous devices is considered a key factor involved in the pathogenesis of Candida catheter-related bloodstream infections (CCRBSI). The biofilm production of strains of Candida spp. isolated both from the CVC and from the blood of patients with CCRBSI was compared to that of strains isolated from patients not having CCRBSI. Results, expressed in terms of Biofilm Index (BI), revealed that biofilm-producing strains were isolated in the CCRBSI group with a frequency significantly higher than in the non-CCRBSI group (χ(2) = 4.25, p = 0.03). The specie...
Source: Adv Data - September 15, 2017 Category: Epidemiology Authors: Brunetti G, Visconti V, Ghezzi MC, Giordano A, Raponi G Tags: Adv Exp Med Biol Source Type: research
Nanodroplet-Containing Polymers for Efficient Low-Power Light Upconversion.
Abstract Sensitized triplet-triplet-annihilation-based photon upconversion (TTA-UC) permits the conversion of light into radiation of higher energy and involves a sequence of photophysical processes between two dyes. In contrast to other upconversion schemes, TTA-UC allows the frequency shifting of low-intensity light, which makes it particularly suitable for solar-energy harvesting technologies. High upconversion yields can be observed for low viscosity solutions of dyes; but, in solid materials, which are better suited for integration in devices, the process is usually less efficient. Here, it is shown that this...
Source: Adv Data - September 12, 2017 Category: Epidemiology Authors: Vadrucci R, Monguzzi A, Saenz F, Wilts BD, Simon YC, Weder C Tags: Adv Mater Source Type: research