Liquid Metal Memory
This article is protected by copyright. All rights reserved.PMID:38037474 | DOI:10.1002/adma.202309182 (Source: Adv Data)
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Ruizhi Yuan Yingjie Cao Xiyu Zhu Xiaohui Shan Bo Wang Hongzhang Wang Sen Chen Jing Liu Source Type: research
Primary care nurse's role and educational preparedness in skin cancer screening and early detection: A scoping review
CONCLUSION: The roles and responsibilities of nurses working in skin cancer screening and early detection are highly variable, as are the reported training and education programmes. Little research has been conducted to explore this nursing role or the educational requirements needed for proficiency. With appropriate best practice education, it is within most primary care nurses' scope of practice to obtain competence in delivering opportunistic skin cancer screening.IMPACT: While most nurse specialists in dermatology will be proficient in dermoscopy and skin cancer screening, nurses who work in general practice are often ...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Chelsea Beames Pamela Adelson Greg Sharplin Marion Eckert Source Type: research
Parental presence, participation, and engagement in paediatric hospital care: A conceptual delineation
CONCLUSION: These concepts' manifestations are important to parental role attainment but may be inadequately understood and considered by healthcare providers.IMPLICATIONS: Nurses have influence over parents' parental presence, participation, and engagement in their child's care but need support from healthcare institutions to ensure equitable family-integrated care delivery.IMPACT: Problem: Lack of clear definition among these concepts results in incomplete and at times inequitable family-integrated care delivery.FINDINGS: Parental presence is an antecedent to parental participation, and parental presence and participatio...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Ashleigh B Harlow Leila Ledbetter Debra H Brandon Source Type: research
Factors associated with continuing education needs in medication administration among school nurses
CONCLUSIONS: The study found that there was a significant demand for and moderate stress related to continuing education among school nurses. Therefore, it is crucial for the government and school nursing organizations to develop targeted programs focusing on medication administration. These initiatives should be designed to enhance nurses' capabilities and reduce their stress, thereby ensuring safe medication administration on campuses.IMPACT: Continuing education enables school nurses to acquire up-to-date knowledge and improve the workflow in their practice. This study highlights a strong need for education in medicatio...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Hsing-Yi Yu Chun-Hsia Huang Yung-Chao Shen Hui-Ling Lin Li-Chun Chang Source Type: research
Perceived barriers and facilitators to preventing hospital-acquired pressure injury in paediatrics: A qualitative analysis
CONCLUSION: These findings provide valuable insights into the barriers and facilitators that impact paediatric HAPI prevention and can help identify and implement strategies to enhance evidence-based prevention care and prevent HAPI in paediatric settings.IMPACT: Overcoming barriers through evidence-based interventions is essential to reduce HAPI cases, improve patient outcomes, and cut healthcare costs. The findings have practical implications, informing policy and practice for improved preventive measures, education, and staffing in paediatric care, ultimately benefiting patient well-being and reducing HAPIs.PATIENT OR P...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Tanesha A Dimanopoulos Wendy Chaboyer Karin Plummer Sharon Mickan Amanda J Ullman Jill Campbell Bronwyn R Griffin Source Type: research
Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus 'GoraVir' for the treatment of pancreatic ductal adenocarcinoma
Mol Oncol. 2023 Dec 1. doi: 10.1002/1878-0261.13561. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense stromal tissue, and immune-suppressive tumor microenvironment. Oncolytic virotherapy has emerged as a new treatment modality which uses tumor-specific viruses to eliminate cancerous cells. Non-human primate adenoviruses of the human adenovirus B (HAdV-B) species have demonstrated considerable lytic potential in human cancer cells as well as limited preexisting neutraliz...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Selas T F Bots Tom J Harryvan Christianne Groeneveldt Priscilla Kinderman Vera Kemp Nadine van Montfoort Rob C Hoeben Source Type: research
Chinese Neonatal Nurses' Lived Experiences of Providing End-of-Life Care in the NICU: A Descriptive Phenomenological Study
Adv Neonatal Care. 2023 Dec 1;23(6):532-540. doi: 10.1097/ANC.0000000000001113. Epub 2023 Oct 16.ABSTRACTBACKGROUND: Although end-of-life care (EOLC) has been well-studied, the experience of neonatal intensive care unit (NICU) nurses in China, where little EOLC training is provided, requires further investigation.PURPOSE: To explore the lived experience of EOLC delivery among NICU nurses, to provide evidence to enhance nurses' EOLC skills and improve their overall quality.METHODS: This qualitative study adopted a phenomenological approach. A total of 11 NICU nurses participated in semistructured in-depth interviews between...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Suo Tong-Hui Lu Qi Rui Xiao-Li Yang Guo-Qin Wang Li-Ping Wang Lin Source Type: research
EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors
Sci Adv. 2023 Dec;9(48):eadg9721. doi: 10.1126/sciadv.adg9721. Epub 2023 Dec 1.ABSTRACTThe efficacy of CAR-T cells for solid tumors is unsatisfactory. EpCAM is a biomarker of epithelial tumors, but the clinical feasibility of CAR-T therapy targeting EpCAM is lacking. Here, we report pre- and clinical investigations of EpCAM-CAR-T cells for solid tumors. We demonstrated that EpCAM-CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice. Notably, in clinical trials for epithelial tumors (NCT02915445), 6 (50%) of the 12 enrolled patien...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Dan Li Xianling Guo Kun Yang Yuening Yang Weilin Zhou Yong Huang Xiao Liang Jinhua Su Lin Jiang Jing Li Maorong Fu Haixia He Jinrong Yang Huashan Shi Hanshuo Yang Aiping Tong Nianyong Chen Jiankun Hu Qing Xu Yu-Quan Wei Wei Wang Source Type: research
Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific G αq signaling
Sci Adv. 2023 Dec;9(48):eadg8118. doi: 10.1126/sciadv.adg8118. Epub 2023 Dec 1.ABSTRACTSyncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading to the hypothesis that excess Gαq signaling within the syncytiotrophoblast may contribute. First, we present data supporting increased Gαq signaling and antioxidant responses within villous and syncytiotrophoblast samples of human preeclamptic placenta. Second, Gαq was activated in mouse placenta using Cre-lox ...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Megan A Opichka M Christine Livergood Kirthikaa Balapattabi McKenzie L Ritter Daniel T Brozoski Kelsey K Wackman Ko-Ting Lu Kaleigh N Kozak Clive Wells Agnes B Fogo Katherine N Gibson-Corley Anne E Kwitek Curt D Sigmund Jennifer J McIntosh Justin L Grobe Source Type: research
Excess mortality in U.S. prisons during the COVID-19 pandemic
Sci Adv. 2023 Dec;9(48):eadj8104. doi: 10.1126/sciadv.adj8104. Epub 2023 Dec 1.ABSTRACTU.S. prisons were especially susceptible to COVID-19 infection and death; however, data limitations have precluded a national accounting of prison mortality (including but not limited to COVID-19 mortality) during the pandemic. Our analysis of mortality data collected from public records requests (supplemented with publicly available data) from 48 Departments of Corrections provides the most comprehensive understanding to date of in-custody mortality during 2020. We find that total mortality increased by 77% in 2020 relative to 2019, cor...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Naomi F Sugie Kristin Turney Keramet Reiter Rebecca Tublitz Daniela Kaiser Rebecca Goodsell Erin Secrist Ankita Patil Monik Jim énez Source Type: research
Real-time gigahertz free-space quantum key distribution within an emulated satellite overpass
Sci Adv. 2023 Dec;9(48):eadj5873. doi: 10.1126/sciadv.adj5873. Epub 2023 Dec 1.ABSTRACTSatellite quantum key distribution (SatQKD) intermediated by a trusted satellite in a low-Earth orbit to ground stations along the satellite's path allows remote users to connect securely. To establish a secure connection, a SatQKD session must be conducted to each user over a dynamically changing free-space link, all within just a few hundred seconds. Because of the short time and large losses under which the QKD protocol will be implemented, it has not yet been possible to form a complete key by transmitting all the relevant informatio...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Thomas Roger Ravinder Singh Chithrabhanu Perumangatt Davide G Marangon Mirko Sanzaro Peter R Smith Robert I Woodward Andrew J Shields Source Type: research
Proposition of Adaptive Read Bias: A Solution to Overcome Power and Scaling Limitations in Ferroelectric-Based Neuromorphic System
Adv Sci (Weinh). 2023 Dec 1:e2303735. doi: 10.1002/advs.202303735. Online ahead of print.ABSTRACTHardware neuromorphic systems are crucial for the energy-efficient processing of massive amounts of data. Among various candidates, hafnium oxide ferroelectric tunnel junctions (FTJs) are highly promising for artificial synaptic devices. However, FTJs exhibit non-ideal characteristics that introduce variations in synaptic weights, presenting a considerable challenge in achieving high-performance neuromorphic systems. The primary objective of this study is to analyze the origin and impact of these variations in neuromorphic syst...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Ryun-Han Koo Wonjun Shin Seungwhan Kim Jiseong Im Sung-Ho Park Jong Hyun Ko Dongseok Kwon Jae-Joon Kim Daewoong Kwon Jong-Ho Lee Source Type: research
Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults
Blood Adv. 2023 Dec 1:bloodadvances.2023011862. doi: 10.1182/bloodadvances.2023011862. Online ahead of print.ABSTRACTVarious socioeconomic and biologic factors impact cancer health disparities and differences in health outcomes. To better characterize the socioeconomic versus biologic determinants of acute lymphoblastic leukemia (ALL) outcomes, we conducted a single-institution, retrospective analysis of adult patients with ALL treated at the University of Chicago (UChicago) from 2010 to 2022, and compared our outcomes with the United States national data (SEER database). Among 221 adult patients with ALL treated at UChica...
Source: Adv Data - December 1, 2023 Category: Epidemiology Authors: Hannah Johnston Hamed Rahmani Youshanlouei Clinton Osei Anand A Patel Adam S DuVall Peng Wang Pankhuri Wanjari Jeremy P Segal Girish Venkataraman Jason Xiaojun Cheng Sandeep Gurbuxani Angela M Lager Carrie Fitzpatrick Michael J Thirman Mariam T Nawas Hong Source Type: research
Bivariate Causal Discovery for Categorical Data via Classification with Optimal Label Permutation
Adv Neural Inf Process Syst. 2022 Dec;35:10837-10848.ABSTRACTCausal discovery for quantitative data has been extensively studied but less is known for categorical data. We propose a novel causal model for categorical data based on a new classification model, termed classification with optimal label permutation (COLP). By design, COLP is a parsimonious classifier, which gives rise to a provably identifiable causal model. A simple learning algorithm via comparing likelihood functions of causal and anti-causal models suffices to learn the causal direction. Through experiments with synthetic and real data, we demonstrate the f...
Source: Adv Data - November 30, 2023 Category: Epidemiology Authors: Yang Ni Source Type: research
Identification of Kikuchi lines in electron diffraction patterns collected in small-angle geometry
Acta Crystallogr A Found Adv. 2024 Jan 1. doi: 10.1107/S2053273323009385. Online ahead of print.ABSTRACTIt is demonstrated that Kikuchi features become clearly visible if reflection high-energy electron diffraction (RHEED) patterns are filtered using digital image processing software. The results of such pattern transformations are shown for SrTiO3 with mixed surface termination for data collected at different azimuths of the incident electron beam. A simplified analytical approach for the theoretical description of filtered Kikuchi patterns is proposed and discussed. Some examples of raw and filtered patterns for thin fil...
Source: Adv Data - November 30, 2023 Category: Epidemiology Authors: Zbigniew Mitura Grzegorz Szwachta Łukasz Kokosza Marek Przybylski Source Type: research
