Why COVID-19 modelling of progression and prevention fails to translate to the real-world
Adv Biol Regul. 2022 Sep 24:100914. doi: 10.1016/j.jbior.2022.100914. Online ahead of print.ABSTRACTMathematical models were used widely to inform policy during the COVID pandemic. However, there is a poor understanding of their limitations and how they influence decision-making. We used systematic review search methods to find early modelling studies that determined the reproduction number and analysed its use and application to interventions and policy in the UK. Up to March 2020, we found 42 reproduction number estimates (39 based on Chinese data: R0 range 2.1-6.47). Several biases affect the quality of modelling studie...
Source: Adv Data - October 1, 2022 Category: Epidemiology Authors: Carl J Heneghan Tom Jefferson Source Type: research

Long-term outcomes in Rheumatoid Arthritis: Review of data from the 'Basildon Inflammatory Arthritis Cohort'
CONCLUSION: Long-term analysis reveals that mortality in RA remains significantly elevated compared with the general population. Additionally, this real-world study underlines malignancy as the predominant cause of morbidity and mortality in RA.PMID:36176320 | PMC:PMC9514795 | DOI:10.1093/rap/rkac075 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Kanishk Jain Deena Laila Anupama Nandagudi Anurag Bharadwaj Source Type: research

Interobserver Variability of Gross Tumor Volume Delineation for Colorectal Liver Metastases Using Computed Tomography and Magnetic Resonance Imaging
CONCLUSIONS: This study reported the lowest interobserver variability for the MR LAVA, thus indicating the benefit of using MR to complement CT when contouring GTV for colorectal liver metastases.PMID:36176355 | PMC:PMC9513217 | DOI:10.1016/j.adro.2022.101020 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Cora Marshall Pierre Thirion Alina Mihai John G Armstrong Se án Cournane Darina Hickey Brendan McClean John Quinn Source Type: research

De-risking clinical trial failure through mechanistic simulation
Immunother Adv. 2022 Aug 23;2(1):ltac017. doi: 10.1093/immadv/ltac017. eCollection 2022.ABSTRACTDrug development typically comprises a combination of pre-clinical experimentation, clinical trials, and statistical data-driven analyses. Therapeutic failure in late-stage clinical development costs the pharmaceutical industry billions of USD per year. Clinical trial simulation represents a key derisking strategy and combining them with mechanistic models allows one to test hypotheses for mechanisms of failure and to improve trial designs. This is illustrated with a T-cell activation model, used to simulate the clinical trials ...
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Liam V Brown Jonathan Wagg Rachel Darley Andy van Hateren Tim Elliott Eamonn A Gaffney Mark C Coles Source Type: research

metabolomicsR: a streamlined workflow to analyze metabolomic data in R
Bioinform Adv. 2022 Sep 16;2(1):vbac067. doi: 10.1093/bioadv/vbac067. eCollection 2022.ABSTRACTSUMMARY: metabolomicsR is a streamlined, flexible and user-friendly R package to preprocess, analyze and visualize metabolomic data. metabolomicsR includes comprehensive functionalities for sample and metabolite quality control, outlier detection, missing value imputation, dimensional reduction, batch effect normalization, data integration, regression, metabolite annotation and visualization of data and results. In this application note, we demonstrate the step-by-step use of the main functions from this package.AVAILABILITY AND ...
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Xikun Han Liming Liang Source Type: research

Hazardous Attitudes: Physician Decision Making in Radiation Oncology
CONCLUSIONS: To our knowledge, this represents the first study analyzing physician attitudes in RO and their effect on self-reported treatment decisions. This work suggests that attitude may be among the factors that influence risk-tolerant prescribing practices and compliance with Choosing Wisely recommendations.PMID:36177486 | PMC:PMC9513093 | DOI:10.1016/j.adro.2022.101033 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Nadia A Saeed Adriana Blakaj Jacqueline R Kelly Roy H Decker Eric C Ford Derek W Brown Arie P Dosoretz Suzanne B Evans Source Type: research

Safety and Tolerability of Metastasis-Directed Radiation Therapy in the Era of Evolving Systemic, Immune, and Targeted Therapies
CONCLUSIONS: Suggested approaches are described, using up-to-date literature, to aid clinicians in navigating the integration of newer targeted agents with hypofractionated palliative and/or ablative metastatic RT. Further prospective studies are required.PMID:36177487 | PMC:PMC9513086 | DOI:10.1016/j.adro.2022.101022 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Elizabeth Guimond Chiaojung Jillian Tsai Ali Hosni Grainne O'Kane Jonathan Yang Aisling Barry Source Type: research

Women's behaviours towards cervical cancer screening in the COVID-19 pandemic: A moderated-mediation-model based on Information-Motivation-Behavioural Skills
CONCLUSION: Our study revealed that as women's motivation for cervical cancer screening increased, their behavioural skills also increased. It can be stated that middle-aged and older women with higher behavioural skills are more likely to have screening during the pandemic and to comply with national recommendations.IMPACT: This study is the first quantitative study to test the impact of the components of the Information-Motivation-Behavioural Skills model on cervical cancer screening during the COVID-19 pandemic. In addition, the results reveal the mediating effect of behavioural skills in the relationship between motiva...
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Ay şe Taştekin Ouyaba Selma İnfal Kesim Source Type: research

Machine learning-accelerated development of efficient mixed protonic-electronic conducting oxides as the air electrodes for protonic ceramic cells
This article is protected by copyright. All rights reserved.PMID:36177694 | DOI:10.1002/adma.202203446 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Ning Wang Baoyin Yuan Chunmei Tang Lei Du Ruijie Zhu Yoshitaka Aoki Weibo Wang Lixin Xing Siyu Ye Source Type: research

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome
In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a decrease in in vivo BM infiltration. Characterization of gene regulatory networks using scRNA-seq identified regulons associated to activation and exhaustion up-regulated in CARHigh T cells, providing mechanistic insights behind differential functionality of these cells. Last, we demonstrate that patients tr...
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Paula Rodriguez-Marquez Maria E Calleja-Cervantes Guillermo Serrano Aina Oliver-Caldes Maria L Palacios-Berraquero Angel Martin-Mallo Cristina Calvi ño Marta Espa ñol-Rego Candela Ceballos Teresa Lozano Patxi San Martin-Uriz Amaia Vilas-Zornoza Saray Ro Source Type: research

Most users do not follow political elites on Twitter; those who do show overwhelming preferences for ideological congruity
Sci Adv. 2022 Sep 30;8(39):eabn9418. doi: 10.1126/sciadv.abn9418. Epub 2022 Sep 30.ABSTRACTWe offer comprehensive evidence of preferences for ideological congruity when people engage with politicians, pundits, and news organizations on social media. Using 4 years of data (2016-2019) from a random sample of 1.5 million Twitter users, we examine three behaviors studied separately to date: (i) following of in-group versus out-group elites, (ii) sharing in-group versus out-group information (retweeting), and (iii) commenting on the shared information (quote tweeting). We find that the majority of users (60%) do not follow any ...
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Magdalena Wojcieszak Andreu Casas Xudong Yu Jonathan Nagler Joshua A Tucker Source Type: research

Influence of Health Education on Podiatric Knowledge, Self-care, and Conditions in Adults With Diabetes Mellitus: A Systematic Review
CONCLUSIONS: Health education interventions increase podiatric self-care in adults with diabetes mellitus. These interventions appear to contribute positively to foot health and podiatric knowledge.PMID:36179316 | DOI:10.1097/01.ASW.0000884328.49506.7a (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Paula Fern ández-León Inmaculada C Palomo-Toucedo Lidia Carvajal-Moreno Gabriel Dom ínguez-Maldonado Sandra S ánchez-Sánchez Mar ía Reina-Bueno Source Type: research

Quality of Care and Cost-Effectiveness: Optimizing Wound Care in the Netherlands
CONCLUSIONS: Prompt triage, analyses, and treatment of underlying causes by specialized doctors in a multidisciplinary setting offer enormous potential for cost savings. The conservative estimate is that approximately €135,000,000 to €293,000,000 can be saved in annual healthcare costs in the Netherlands using this protocol.PMID:36179322 | DOI:10.1097/01.ASW.0000874164.88278.70 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Wouter Brekelmans Boudewijn L S Borger van der Burg Nicole J Tolen Rigo Hoencamp Source Type: research

Movement Patterns of Transient and Prolonged Positioning Events in Nursing Home Residents: Results from the TEAM-UP Trial
CONCLUSIONS: The NH residents demonstrate complex patterns of movements of both short and prolonged duration while lying and sitting. Findings represent how NH residents naturally move in real-world conditions and provide a new set of metrics to study tissue offloading and its role in pressure injury prevention.PMID:36179323 | DOI:10.1097/01.ASW.0000874172.68863.1c (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Kais Gadhoumi Sharon Eve Sonenblum Susan M Kennerly Jenny Alderden Phoebe D Sharkey Susan D Horn Tracey L Yap Source Type: research

Long-term outcomes in Rheumatoid Arthritis: Review of data from the 'Basildon Inflammatory Arthritis Cohort'
CONCLUSION: Long-term analysis reveals that mortality in RA remains significantly elevated compared with the general population. Additionally, this real-world study underlines malignancy as the predominant cause of morbidity and mortality in RA.PMID:36176320 | PMC:PMC9514795 | DOI:10.1093/rap/rkac075 (Source: Adv Data)
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Kanishk Jain Deena Laila Anupama Nandagudi Anurag Bharadwaj Source Type: research