Drinking water and sanitation conditions are associated with the risk of malaria among children under five years old in sub-Saharan Africa: A logistic regression model analysis of national survey data.
Abstract Current efforts for the prevention of malaria have resulted in notable reductions in the global malaria burden; however, they are not enough. Good hygiene is universally considered one of the most efficacious and straightforward measures to prevent disease transmission. This work analyzed whether improved drinking water and sanitation (WS) conditions were associated with a decreased risk of malaria infection. Data were acquired through surveys published between 2006 and 2018 from the Demographic and Health Program in sub-Saharan Africa (SSA). Multiple logistic regression was used for each national survey ...
Source: Adv Data - October 25, 2019 Category: Epidemiology Authors: Yang D, He Y, Wu B, Deng Y, Li M, Yang Q, Huang L, Cao Y, Liu Y Tags: J Adv Res Source Type: research
Walking on the Moon: A randomized clinical trial on the role of lower body positive pressure treadmill training in post-stroke gait impairment.
i P, Naro A Abstract Body weight-supported treadmill training (BWSTT) can be usefully employed to facilitate gait recovery in patients with neurological injuries. Specifically, lower body positive pressure support system (LBPPSS) decreases weight-bearing and ground reaction forces with potentially positive effects on qualitative gait indices. However, which gait features are being shaped by LBPPSS in post-stroke patients is yet poorly predictable. A pilot study on the effects of LBPPSS on qualitative and quantitative gait indices was carried out in patients with hemiparesis due to stroke in the chronic phase. Fift...
Source: Adv Data - October 25, 2019 Category: Epidemiology Authors: Calabrò RS, Billeri L, Andronaco VA, Accorinti M, Milardi D, Cannavò A, Aliberti E, Militi A, Bramanti P, Naro A Tags: J Adv Res Source Type: research
Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Abstract Thymic mucoepidermoid carcinoma is a rare tumor that remains poorly characterized and a diagnostic challenge. The aim of this review is to characterize this tumor in a larger cohort of patients using all the available cases in the literature. We systematically searched the PubMed and Scopus database for primary thymic mucoepidermoid carcinoma. A total of 24 studies were included in the final analysis. A total of 41 patients were identified; 23 (56.1%) were male and 18 (43.9%) were female. Mean age was 49.8±21.3 years. Mean tumor size was 7.6±3.5 cm. Twenty (66.7%) were low grade and 8...
Source: Adv Data - October 9, 2019 Category: Epidemiology Authors: Hamza A, Younes AI, Kalhor N Tags: Adv Anat Pathol Source Type: research
Changes in life expectancy for cancer patients over time since diagnosis.
, De Angelis R, Buzzoni C, Capocaccia R, AIRTUM Working Group Abstract The aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patients' entire lives. Cancer patients' LE was calculated by standard period life table methodology using the relative survival of Italian patients diagnosed in population-based cancer registries in 1985-2011 with follow-up to 2013. Data were smoothed using a polynomial model and years of life lost (YLL) were calculated as the difference between patients' LE and t...
Source: Adv Data - September 1, 2019 Category: Epidemiology Authors: Botta L, Dal Maso L, Guzzinati S, Panato C, Gatta G, Trama A, Rugge M, Tagliabue G, Casella C, Caruso B, Michiara M, Ferretti S, Sensi F, Tumino R, Toffolutti F, Russo AG, Caiazzo AL, Mangone L, Mazzucco W, Iacovacci S, Ricci P, Gola G, Candela G, Sardo A Tags: J Adv Res Source Type: research
Genetic programming approach for predicting service life of tunnel structures subject to chloride-induced corrosion.
Abstract A new method for predicting the service life of tunnel structures subject to chloride-induced corrosion using data from real engineering examples and genetic programming (GP) is proposed. As a data-driven method, the new approach can construct explicit expressions of the prediction model. The new method was verified by comparing it with the chloride-ion diffusion model considering eight corrosion influence factors. Moreover, 25 datasets collected from tunnel engineering examples were used to construct the new prediction model considering 17 corrosion influence factors belonged to just one classification o...
Source: Adv Data - August 29, 2019 Category: Epidemiology Authors: Gao W, Chen X, Chen D Tags: J Adv Res Source Type: research
Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells.
In this study, systematic separation and subsequent pharmacological activity studies were carried out to identify cytotoxic natural products from the dried stems of Millettia pachyloba Drake. Five previously undescribed isoflavones, pachyvones A-E; one previously undescribed xanthone, pachythone A; and twenty-two known compounds were obtained. The structures of these compounds were assigned on the basis of 1D/2D NMR data and high-resolution electrospray ionization mass spectroscopy analysis. Preliminary activity screening with HeLa and MCF-7 cells showed that ten compounds (3-5, 9, 12, 17-19, 24, and 25) had potential cyto...
Source: Adv Data - July 26, 2019 Category: Epidemiology Authors: Yan W, Yang J, Tang H, Xue L, Chen K, Wang L, Zhao M, Tang M, Peng A, Long C, Chen X, Ye H, Chen L Tags: J Adv Res Source Type: research
Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival.
ml;dör C, Győrffy B Abstract Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant myeloid disorder in adults. Several gene mutations such as in NPM1 (nucleophosmin 1) are involved in the pathogenesis and progression of AML. The aim of this study was to identify genes whose expression is associated with driver mutations and survival outcome. Genotype data (somatic mutations) and gene expression data including RNA-seq, microarray, and qPCR data were used for the analysis. Multiple datasets were utilized as training sets (GSE6891, TCGA, and GSE1159). ...
Source: Adv Data - July 24, 2019 Category: Epidemiology Authors: Nagy Á, Ősz Á, Budczies J, Krizsán S, Szombath G, Demeter J, Bödör C, Győrffy B Tags: J Adv Res Source Type: research
LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer.
Abstract The efficacy of gemcitabine therapy is often insufficient for the treatment of pancreatic cancer. The current study demonstrated that LW6, a chemical inhibitor of hypoxia-inducible factor 1α, is a promising drug for enhancing the chemosensitivity to gemcitabine. LW6 monotherapy and the combination therapy of LW6 plus gemcitabine significantly inhibited cell proliferation and enhanced cell death in pancreatic cancer cells. This combination therapy also significantly reduced the tumor weight in a syngeneic orthotopic pancreatic carcinoma model without causing toxic side effects. In addition, this stud...
Source: Adv Data - June 15, 2019 Category: Epidemiology Authors: Zhang X, Kumstel S, Jiang K, Meng S, Gong P, Vollmar B, Zechner D Tags: J Adv Res Source Type: research
To reveal pharmacological targets and molecular mechanisms of curcumol against interstitial cystitis.
In conclusion, the current bioinformatic data and preliminary findings unravel that the predominant targets of curcumol against IC may be the potential biological markers for screening and treating IC, such as PTK2 molecule. PMID: 31193808 [PubMed] (Source: Adv Data)
Source: Adv Data - June 15, 2019 Category: Epidemiology Authors: Wu K, Wei P, Liu M, Liang X, Su M Tags: J Adv Res Source Type: research
Advanced DNA fingerprint genotyping based on a model developed from real chip electrophoresis data.
This study presents a new approach based on global multiple alignments of bands of all samples, with an adaptive threshold derived from the detailed migration analysis of a large number of real samples. The proposed approach allows the accurate automated analysis of DNA fingerprint similarities for extensive epidemiological studies of bacterial strains, thereby helping to prevent the spread of dangerous microbial infections. PMID: 30788173 [PubMed] (Source: Adv Data)
Source: Adv Data - February 24, 2019 Category: Epidemiology Authors: Skutkova H, Vitek M, Bezdicek M, Brhelova E, Lengerova M Tags: J Adv Res Source Type: research
Boot Camp for Caregivers of Children With Medically Complex Conditions.
Abstract BACKGROUND: The safe transition of children with complex medical conditions who are dependent on technology from hospital to home requires that caregivers receive specialized training from qualified health care professionals. Inadequate caregiver training can lead to discharge delays and hospital readmissions, often resulting in caregiver distress. OBJECTIVE: To determine the effectiveness of a structured boot camp-style predischarge training program for caregivers of pediatric patients with complex medical conditions. METHODS: We conducted a quasi-experimental interventional study to compare ou...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Van Orne J, Branson K, Cazzell M Tags: AACN Adv Crit Care Source Type: research
Reducing Tracheostomy-Related Pressure Injuries.
Abstract An interprofessional team was established to prevent tracheostomy-related acquired pressure injuries. The team performed an in-depth analysis of practice from tracheostomy insertion through postinsertion care. A literature evaluation identified best practices, and a root cause analysis for all tracheostomy-related pressure injury cases identified common causes. Lessons learned from the practice and literature reviews drove care standardization and reduced variation. Preimplementation and postimplementation data were analyzed to determine the effectiveness of improvement interventions. Improvement strategi...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Dixon LM, Mascioli S, Mixell JH, Gillin T, Upchurch CN, Bradley KM Tags: AACN Adv Crit Care Source Type: research
Abstract The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of peric...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Gaceb A, Paul G Tags: Adv Exp Med Biol Source Type: research
Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure.
Conclusions: These data can help inform healthcare professionals and women with MS exposed to fingolimod during conception. PMID: 30542374 [PubMed] (Source: Adv Data)
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Geissbühler Y, Vile J, Koren G, Guennec M, Butzkueven H, Tilson H, MacDonald TM, Hellwig K Tags: Ther Adv Neurol Disord Source Type: research
Protein Localization and Interaction Studies in Plants: Toward Defining Complete Proteomes by Visualization.
Abstract Protein interaction and localization studies in plants are a fundamental component of achieving mechanistic understanding of virus:plant interactions at the systems level. Many such studies are conducted using transient expression assays in leaves of Nicotiana benthamiana, the most widely used experimental plant host in virology, examined by laser-scanning confocal microscopy. This chapter provides a workflow for protein interaction and localization experiments, with particular attention to the many control and supporting assays that may also need to be performed. Basic principles of microscopy are introd...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Goodin MM Tags: Adv Virus Res Source Type: research
Hosts and Sources of Endemic Human Coronaviruses.
Abstract The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in major livestock species while primordial associations for all four viruses may have existed with bats and rodents. HCoV-NL63 and -229E ...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Corman VM, Muth D, Niemeyer D, Drosten C Tags: Adv Virus Res Source Type: research
Changing Role of Wild Birds in the Epidemiology of Avian Influenza A Viruses.
Abstract Waterbirds are the main reservoir for low pathogenic avian influenza A viruses (LPAIV), from which occasional spillover to poultry occurs. When circulating among poultry, LPAIV may become highly pathogenic avian influenza A viruses (HPAIV). In recent years, the epidemiology of HPAIV viruses has changed drastically. HPAIV H5N1 are currently endemic among poultry in a number of countries. In addition, global spread of HPAIV H5Nx viruses has resulted in major outbreaks among wild birds and poultry worldwide. Using data collected during these outbreaks, the role of migratory birds as a vector became increasin...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Bodewes R, Kuiken T Tags: Adv Virus Res Source Type: research
Laparoscopic D2 Gastrectomy for Gastric Cancer: Mid-Term Results and Current Evidence.
CONCLUSION: Laparoscopic gastrectomy can be performed safely with excellent short- and mid-term results. As experience increases, surgical duration is reduced and lymph node count rises. PMID: 30526290 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - December 11, 2018 Category: Epidemiology Authors: Dias AR, Jacob CE, Ramos MFKP, Pereira MA, Szor DJ, Yagi OK, Barchi LC, Ribeiro U, Zilberstein B, Cecconello I Tags: J Laparoendosc Adv Surg Tech A Source Type: research
The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma.
Abstract Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) family proteins. Here, we provide evidence to support pharmacologically targeting IAPs in lymphoma with LCL-161, a small molecule mimetic of the second mitochondria-derived activator of caspases (SMAC). The antitumor effect of LCL-161 was determined using luminescent adenosine triphosphate assays, flow cytometry...
Source: Adv Data - December 11, 2018 Category: Epidemiology Authors: Runckel K, Barth MJ, Mavis C, Gu JJ, Hernandez-Ilizaliturri FJ Tags: Blood Adv Source Type: research
Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.
Abstract The NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 develop severe thrombocytopenia with lethality resulting from neonatal hemorrhage. Recent data in mammals reveal potential differences in embryonic and adult thrombopoiesis. Multiple studies in zebrafish have revealed mechanistic insights into hematopoiesis, although thrombopoiesis has been less studied. Rather than platelets, zebrafish possess thrombocytes, which are nucleated cells with similar functional ...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM, Barrett FG, Stachura DL, Holinstat M, Zon LI, Shavit JA Tags: Blood Adv Source Type: research
The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.
Abstract To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared with normal hematopoietic cells. Inhibiting IKBKE, or its close homolog TANK-binding kinase 1 (TBK1), by either short hairpin RNA knockdown or pharmacological compounds, induces apoptosis and reduces the viability of AML cells. Using gene expression profiling and gene set enrichment analysis, we found that IKBKE/TBK1-sensitive AML cell...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Liu S, Marneth AE, Alexe G, Walker SR, Gandler HI, Ye DQ, Labella K, Mathur R, Toniolo PA, Tillgren M, Gokhale PC, Barbie D, Mullally A, Stegmaier K, Frank DA Tags: Blood Adv Source Type: research
Development of a clinical risk score for pain and function following total knee arthroplasty: results from the TRIO study.
Conclusion: We have developed and validated a clinical prediction model that can be used to identify patients at high risk of a poor outcome after TKA. This clinical risk score may be an aid to shared decision-making between patient and clinician. PMID: 30506023 [PubMed] (Source: Adv Data)
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Shim J, Mclernon DJ, Hamilton D, Simpson HA, Beasley M, Macfarlane GJ Tags: Rheumatol Adv Pract Source Type: research
Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.
;tze KS Abstract Mesenchymal stromal cells (MSCs) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival, and differentiation of hematopoietic stem/progenitor cells (HSPCs) in the stem cell niche. MSCs are functionally altered in myelodysplastic syndromes (MDS) and exhibit an altered methylome compared with MSCs from healthy controls, thus contributing to disease progression. To determine whether MSCs are amenable to epigenetic therapy and if this affects their function, we examined growth, differentiation, and HSPC-supporting capacity of ex vivo-expanded MS...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M, Götze KS Tags: Blood Adv Source Type: research
Who are the right teachers for medical clinical students? Investigating stakeholders' opinions using modified Delphi approach.
Conclusion: The results of this study indicated the necessity of forming a teaching team, paying attention to the selection criteria, and planning requirements for assigning responsibilities to the teaching team in accordance with the objectives, programs, and requirements of medical schools, along with using strategies to attract participation and create motivation in the teaching team. PMID: 30519136 [PubMed] (Source: Adv Data)
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Shaterjalali M, Yamani N, Changiz T Tags: Adv Med Educ Pract Source Type: research
Acetabular Debonding: An Investigation of Porous Coating Delamination in Hip Resurfacing Arthroplasty.
This study aims to summarize the current understanding of acetabular debonding and to investigate the discrepancy in rate of debonding between two implant systems. Patients and Methods: To elucidate potential causes of debonding, we retrospectively analyzed a single-surgeon cohort of 839 hip resurfacing cases. Specifically, we compared rate of debonding and manufacturing processes between two implant systems. Results: Group 1 experienced significantly more cases of debonding than Group 2 cases (4.0% versus 0.0%, p value
Source: Adv Data - December 7, 2018 Category: Epidemiology Authors: Robinson E, Gaillard-Campbell D, Gross TP Tags: Adv Orthop Source Type: research
Clinical practice, deliberate practice, and "big data".
Clinical practice, deliberate practice, and "big data". Adv Health Sci Educ Theory Pract. 2018 Dec;23(5):863-866 Authors: Norman G Abstract PMID: 30421094 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - November 14, 2018 Category: Epidemiology Authors: Norman G Tags: Adv Health Sci Educ Theory Pract Source Type: research
Alterations in platelet secretion differentially affect thrombosis and hemostasis.
Abstract We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2 and VAMP3. VAMP2Δ3Δ8-/- platelets also had reduced VAMP7. Loss of VAMP2 and VAMP3 (VAMP2Δ3Δ) had a minimal impact on secretion when VAMP7 and VAMP8 were present. Integrin αIIbβ3 activation and aggregation were not affected, although spreading was reduced in VAMP2Δ3&Delt...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Joshi S, Banerjee M, Zhang J, Kesaraju A, Pokrovskaya ID, Storrie B, Whiteheart SW Tags: Blood Adv Source Type: research
Using Health System Data for Improvement Science: Getting Started.
PMID: 30185502 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Zhao Y, Granger BB Tags: AACN Adv Crit Care Source Type: research
Abiraterone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: a systematic review of 'real-life' studies.
Conclusions: Despite the high grade of heterogeneity among studies, treatment with AA seems to ensure good survival outcomes in the 'real-life' setting. However, prospective studies based on patients' characteristics being more similar to 'real-life' patients are necessary. PMID: 30186368 [PubMed] (Source: Adv Data)
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Marchioni M, Sountoulides P, Bada M, Rapisarda S, De Nunzio C, Tamburro FR, Schips L, Cindolo L Tags: Ther Adv Urol Source Type: research
Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide.
Abstract Published reports suggest that immune checkpoint inhibitors (ICIs) before allogeneic blood or marrow transplantation (alloBMT) may increase the incidence of graft-versus-host disease (GvHD), immune-related adverse events, and nonrelapse mortality (NRM); this led to the US Food and Drug Administration issuing a "Warning and Precaution" regarding the potential for life-threatening immune-mediated complications associated with alloBMT after nivolumab and pembrolizumab. We retrospectively reviewed the outcomes of 14 consecutive patients who received ICIs as their final salvage therapy before T-cell-...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Schoch LK, Cooke KR, Wagner-Johnston ND, Gojo I, Swinnen LJ, Imus P, Fuchs EJ, Levis M, Ambinder RF, Jones RJ, Gladstone DE Tags: Blood Adv Source Type: research
Systematic Identification of Non-coding RNAs.
Abstract Non-coding RNAs (ncRNAs) are biologically significant in variable ways. They modulate gene expression at the levels of transcription and post-transcription. MiRNAs and lncRNAs are two major classes of non-coding RNAs and have been extensively characterized. They are implicated in various biological processes and diseases. Thus, identification of miRNAs and lncRNAs are fundamental to further understand their roles and dissect their mechanisms. Here, we overviewed pipelines of identifying miRNAs and lncRNAs based on next-generation sequencing technologies. We applied the pipelines to identify miRNAs in mult...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xiao Y, Hu J, Yin W Tags: Adv Exp Med Biol Source Type: research
Functional Characterization of Non-coding RNAs Through Genomic Data Fusion.
Abstract Acting as a class of regulators of gene expression, miRNAs play crucial roles in various biological processes, such as cell proliferation, differentiation, and apoptosis. Increasing evidence indicates that dysregulation of miRNA expression and function is related to the pathogenesis of many human diseases. Here, we applied an integration strategy to identify conserved miRNA co-expression relationships and constructed a miRNA co-expression network based on human and mouse miRNA expression data. We performed large-scale bioinformatics analyses of conserved miRNA co-expression relationships and their functio...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xiao Y, Yan M, Deng C, Zhao H Tags: Adv Exp Med Biol Source Type: research
Profiling DNA Methylation Patterns of Non-coding RNAs (ncRNAs) in Human Disease.
Abstract Although non-coding RNAs (ncRNAs) are commonly considered modulators in human disease, revealing the methylation pattern of ncRNA is still a challenging task. In this chapter, we (1) introduced a strategy of constructing DNA methylation profiles for ncRNAs by reannotating data of DNA methylation arrays; (2) identified methylation patterns of ncRNAs in cancers by classifying ncRNAs into two categories and three subcategories, according to their promoter methylation patterns in tumors; (3) identified lncRNAs with promoter methylation patterns that were associated with cancer status, subtype, or prognosis fo...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Zhi H, Li Y, Wang L Tags: Adv Exp Med Biol Source Type: research
Computationally Modeling ncRNA-ncRNA Crosstalk.
Abstract Our understanding of complex gene regulatory networks have been improved by the discovery of ncRNA-ncRNA crosstalk in normal and disease-specific physiological conditions. Previous studies have proposed numerous approaches for constructing ncRNA-ncRNA networks via ncRNA-mRNA regulation, functional information, or phenomics alone, or by combining heterogeneous data. Furthermore, it has been shown that ncRNA-ncRNA crosstalk can be rewired in different tissues or specific diseases. Therefore, it is necessary to integrate transcriptome data to construct context-specific ncRNA-ncRNA networks. In this chapter, ...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xu J, Bai J, Xiao J Tags: Adv Exp Med Biol Source Type: research
Imatinib rechallenge in patients with advanced gastrointestinal stromal tumors following progression with imatinib, sunitinib and regorafenib.
Conclusions: Our retrospective data confirm that imatinib rechallenge is a reasonable option in advanced GIST. The prognostic value of the specific KIT mutations was confirmed in our series. PMID: 30181783 [PubMed] (Source: Adv Data)
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Vincenzi B, Nannini M, Badalamenti G, Grignani G, Fumagalli E, Gasperoni S, D'Ambrosio L, Incorvaia L, Stellato M, Spalato Ceruso M, Napolitano A, Valeri S, Santini D, Tonini G, Casali PG, Dei Tos AP, Pantaleo MA Tags: Ther Adv Med Oncol Source Type: research
Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology.
ris F Abstract Over the last decades, the concept of precision medicine has dramatically renewed the field of medical oncology; the introduction of patient-tailored therapies has significantly improved all measurable outcomes. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of the detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Many technical hurdles have been resolved thanks to newly developed techniques and next-generation sequencing analyses...
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Palmirotta R, Lovero D, Cafforio P, Felici C, Mannavola F, Pellè E, Quaresmini D, Tucci M, Silvestris F Tags: Ther Adv Med Oncol Source Type: research
The clinical significance of hyperglycemia in nondiabetic critically ill multiple trauma patients.
In this study we investigated the clinical significance of hyperglycemia related to new episodes of ventilator-associated pneumonia in nondiabetic critically ill multiple trauma intensive care unit patients. Materials and Methods: We analyzed the clinical data of 202 critically ill multiple trauma patients with no history of previous diabetes who developed a new ventilator-associated pneumonia episode during their intensive care unit stay. We used a time-from-event analysis method to assess whether acute changes in blood glucose levels that occurred prior to the onset of ventilator-associated pneumonia episodes had a ...
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Koyfman L, Brotfain E, Frank D, Bichovsky Y, Kovalenko I, Benjamin Y, Borer A, Friger M, Klein M Tags: Ther Adv Endocrinol Metab Source Type: research
Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution.
Abstract Hyperspectral imaging (HSI) systems have the potential to retrieve in vivo hemodynamic and metabolic signals from the exposed cerebral cortex. The use of multiple narrow wavelength bands in the near infrared (NIR) range theoretically allows not only to image brain tissue oxygenation and hemodynamics via mapping of hemoglobin concentration changes, but also to directly quantify cerebral metabolism via measurement of the redox states of mitochondrial cytochrome-c-oxidase (CCO). The aim of this study is to assess the possibility of performing hyperspectral imaging of in vivo cerebral oxyhemoglobin (HbO2), de...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Giannoni L, Lange F, Davies AL, Dua A, Gustavson B, Smith KJ, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research
Changes in Spinal Muscle Oxygenation and Perfusion During the Biering-S ørensen Test: Preliminary Results of a Study Employing NIRS-Based Muscle Oximetry.
Changes in Spinal Muscle Oxygenation and Perfusion During the Biering-Sørensen Test: Preliminary Results of a Study Employing NIRS-Based Muscle Oximetry. Adv Exp Med Biol. 2018;1072:103-109 Authors: Vrana A, Scholkmann F, Wirth B, Flueck M, Humphreys BK Abstract Low back pain (LBP) is suggested to be related to deconditioning of back muscles by a decreased capacity for hyperemia in exercising muscles. However, only inconsistent evidence exists regarding back muscle perfusion and oxygen saturation in healthy subjects and patients suffering from (chronic) LBP. AIM: We measured muscle perfusi...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Vrana A, Scholkmann F, Wirth B, Flueck M, Humphreys BK Tags: Adv Exp Med Biol Source Type: research
Trail Making Test Induces Prefrontal Cortex Activation as Revealed by a cw Wearable-Wireless fNIRS/DOT Imager.
Abstract The recent availability of low-cost wearable continuous wave (cw) fNIRS/DOT devices is supposed to revolutionize cortical human brain mapping in the real-life. Ecological paper-pencil tests, as the Trail Making Test (TMT), are commonly used in neuropsychological clinics but its neural substrates are not completely understood. The aim of this study was to map, using a new cw wearable fNIRS/DOT imager (NIRSIT), the prefrontal cortex (PFC) hemodynamic response in healthy subjects while performing the TMT. The ANOVA analysis, performed on the 60 region-DOT data, shows a significant task-related activation of ...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Lancia S, Choi J, Baek J, Mammarella S, Bianco D, Quaresima V, Ferrari M Tags: Adv Exp Med Biol Source Type: research
Septic-Induced microRNA Expression Modulations Are Linked to Angiogenesis, Vasomotion, and Hypoxia-Induced Processes.
Abstract Sepsis is an exaggerated immune reaction to an infection, which leads to organ dysfunction especially circulatory failure. This is based on cellular processes, which are regulated by post-transcriptional gene expression modulations including microRNAs (miRNAs). In order to elucidate the role miRNAs play in septic processes, monocytes and endothelial cells were grown in an inflammatory milieu. In addition, aortas from septic mice were investigated. Expression of miRNAs was analysed by both next generation sequencing (NGS) and NanoString technology, and miRNA targets were identified by in silico analysis. C...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Schmidt B, Roessler C, Schumann J Tags: Adv Exp Med Biol Source Type: research
Analysis of Aortic Remodeling and Stiffness in Patients with Obstructive Sleep Apnea Syndrome: Preliminary Results.
cca A Abstract Obstructive sleep apnea (OSA) is a well-known risk factor for cardiovascular diseases. Several studies have shown that OSA is associated with vessel remodeling, but few studies have examined aorta. AIM: to analyse aortic remodelling in OSA. METHODS: Thirty consecutive OSA patients (22 males and 8 females, aged 58.5 ± 13.2 years) were studied. All patients underwent a morning blood gas analysis, a full cardiorespiratory evaluation, including nocturnal polygraphy and echocardiography, that assessed aortic root diameter (ARD) and aortic stiffness index (ASI). Patients were grouped...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Cicco S, Castellana G, Marra L, Dragonieri S, Carratù P, Ranieri G, Resta O, Vacca A Tags: Adv Exp Med Biol Source Type: research
Hyperbaric Oxygen Therapy in Necrotizing Soft Tissue Infections: A Retrospective Study.
This study considers the success of treatment as a result of complying with optimal therapy. In a contribution to establish coverage use and an inventory of hyperbaric chambers, we also aim to create a national case register, so that patients do not have to depend on long and risky transportations. PMID: 30178356 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Steiner T, Seiffart A, Schumann J, Bucher M Tags: Adv Exp Med Biol Source Type: research
Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET.
Abstract Neuronal activity causes changes in both cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF). Since the relationship between tissue oxygenation and regional CBF (rCBF) during exercise has not been elucidated, we compared the data obtained using near-infrared spectroscopy (NIRS) and rCBF examined using positron emission tomography (PET). Participants in this study comprised 26 healthy young men. Changes in concentration of oxygenated hemoglobin (ΔO2Hb) and deoxygenated hemoglobin (ΔHHb) in the prefrontal cortex (PFC) were measured using NIRS continuously during a 15-min bout...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Hiura M, Nariai T, Takahashi K, Muta A, Sakata M, Ishibashi K, Toyohara J, Wagatsuma K, Tago T, Ishii K, Maehara T Tags: Adv Exp Med Biol Source Type: research
Mucine-1 Is Related to Cell-Mediated Immunoexpression and Blood Pressure in Pulmonary Artery in Pulmonary Arterial Hypertension (PAH): Preliminary Results.
CONCLUSIONS: These preliminary data show a possible mechanism of immune stimulation in PAH patients. This may imply an association between lung parenchyma, immunity and increase in vascular resistance. Additional studies are required to confirm these findings. PMID: 30178358 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Cicco S, Leone P, Racanelli V, Vacca A Tags: Adv Exp Med Biol Source Type: research
The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability.
CONCLUSION: The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability. PMID: 30178359 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Liu TC, Tang XM, Duan R, Ma L, Zhu L, Zhang QG Tags: Adv Exp Med Biol Source Type: research
Investigation of Confounding Factors in Measuring Tissue Saturation with NIRS Spatially Resolved Spectroscopy.
Abstract Performing absolute measurements of tissue saturation of the brain with near-infrared spectroscopy (NIRS) is a clinically desirable brain monitoring tool. Tissue oxygenation index (TOI) is an indicator of absolute tissue mixed arterial and venous oxygen saturation, and can be calculated using a NIRS technique called spatially resolved spectroscopy (SRS). SRS instruments measure the change of light attenuation with distance by using multiple light source-detector distances at two or more wavelengths. The aim of the study is to use broadband NIRS SRS data to investigate the effects on the calculation of TOI...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Kovacsova Z, Bale G, Mitra S, de Roever I, Meek J, Robertson N, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research
ABroAD: A Machine Learning Based Approach to Detect Broadband NIRS Artefacts.
Abstract Artefacts are a common and unwanted aspect of any measurement process, especially in a clinical environment, with multiple causes such as environmental changes or motion. In near-infrared spectroscopy (NIRS), there are several existing methods that can be used to identify and remove artefacts to improve the quality of collected data.We have developed a novel Automatic Broadband Artefact Detection (ABroAD) process, using machine learning methods alongside broadband NIRS data to detect common measurement artefacts using the broadband intensity spectrum. Data were collected from eight subjects, using a broad...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Russell-Buckland J, Bale G, de Roever I, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research
Absolute Values of Optical Properties ( μa, μ΄s, μeff and DPF) of Human Head Tissue: Dependence on Head Region and Individual.
CONCLUSION: Our analysis demonstrates that all optical head tissue properties (μa, [Formula: see text], μeff and DPF) were dependent on the head region, individual subject and age. The optical properties of the head are like a 'fingerprint' for the individual subject. Assuming constant optical properties for the whole head should be carefully reconsidered. PMID: 30178366 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Scholkmann F, Zohdi H, Nasseri N, Wolf U Tags: Adv Exp Med Biol Source Type: research
Long-Term Changes in Optical Properties ( μa, μ's, μeff and DPF) of Human Head Tissue During Functional Neuroimaging Experiments.
Long-Term Changes in Optical Properties (μa, μ's, μeff and DPF) of Human Head Tissue During Functional Neuroimaging Experiments. Adv Exp Med Biol. 2018;1072:331-337 Authors: Zohdi H, Scholkmann F, Nasseri N, Wolf U Abstract Frequency-domain near-infrared spectroscopy (FD-NIRS) enables to measure absolute optical properties (i.e. the absorption coefficient, μa, and the reduced scattering coefficient, [Formula: see text]) of the brain tissue. The aim of this study was to investigate how the optical properties changed during the course of a functional NIRS experiment. The analyzed dataset com...
Source: Adv Data - September 6, 2018 Category: Epidemiology Authors: Zohdi H, Scholkmann F, Nasseri N, Wolf U Tags: Adv Exp Med Biol Source Type: research