Alterations in platelet secretion differentially affect thrombosis and hemostasis.
Abstract We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2 and VAMP3. VAMP2Δ3Δ8-/- platelets also had reduced VAMP7. Loss of VAMP2 and VAMP3 (VAMP2Δ3Δ) had a minimal impact on secretion when VAMP7 and VAMP8 were present. Integrin αIIbβ3 activation and aggregation were not affected, although spreading was reduced in VAMP2Δ3&Delt...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Joshi S, Banerjee M, Zhang J, Kesaraju A, Pokrovskaya ID, Storrie B, Whiteheart SW Tags: Blood Adv Source Type: research

Using Health System Data for Improvement Science: Getting Started.
PMID: 30185502 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Zhao Y, Granger BB Tags: AACN Adv Crit Care Source Type: research

Abiraterone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: a systematic review of 'real-life' studies.
Conclusions: Despite the high grade of heterogeneity among studies, treatment with AA seems to ensure good survival outcomes in the 'real-life' setting. However, prospective studies based on patients' characteristics being more similar to 'real-life' patients are necessary. PMID: 30186368 [PubMed] (Source: Adv Data)
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Marchioni M, Sountoulides P, Bada M, Rapisarda S, De Nunzio C, Tamburro FR, Schips L, Cindolo L Tags: Ther Adv Urol Source Type: research

Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide.
Abstract Published reports suggest that immune checkpoint inhibitors (ICIs) before allogeneic blood or marrow transplantation (alloBMT) may increase the incidence of graft-versus-host disease (GvHD), immune-related adverse events, and nonrelapse mortality (NRM); this led to the US Food and Drug Administration issuing a "Warning and Precaution" regarding the potential for life-threatening immune-mediated complications associated with alloBMT after nivolumab and pembrolizumab. We retrospectively reviewed the outcomes of 14 consecutive patients who received ICIs as their final salvage therapy before T-cell-...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Schoch LK, Cooke KR, Wagner-Johnston ND, Gojo I, Swinnen LJ, Imus P, Fuchs EJ, Levis M, Ambinder RF, Jones RJ, Gladstone DE Tags: Blood Adv Source Type: research

Systematic Identification of Non-coding RNAs.
Abstract Non-coding RNAs (ncRNAs) are biologically significant in variable ways. They modulate gene expression at the levels of transcription and post-transcription. MiRNAs and lncRNAs are two major classes of non-coding RNAs and have been extensively characterized. They are implicated in various biological processes and diseases. Thus, identification of miRNAs and lncRNAs are fundamental to further understand their roles and dissect their mechanisms. Here, we overviewed pipelines of identifying miRNAs and lncRNAs based on next-generation sequencing technologies. We applied the pipelines to identify miRNAs in mult...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xiao Y, Hu J, Yin W Tags: Adv Exp Med Biol Source Type: research

Functional Characterization of Non-coding RNAs Through Genomic Data Fusion.
Abstract Acting as a class of regulators of gene expression, miRNAs play crucial roles in various biological processes, such as cell proliferation, differentiation, and apoptosis. Increasing evidence indicates that dysregulation of miRNA expression and function is related to the pathogenesis of many human diseases. Here, we applied an integration strategy to identify conserved miRNA co-expression relationships and constructed a miRNA co-expression network based on human and mouse miRNA expression data. We performed large-scale bioinformatics analyses of conserved miRNA co-expression relationships and their functio...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xiao Y, Yan M, Deng C, Zhao H Tags: Adv Exp Med Biol Source Type: research

Profiling DNA Methylation Patterns of Non-coding RNAs (ncRNAs) in Human Disease.
Abstract Although non-coding RNAs (ncRNAs) are commonly considered modulators in human disease, revealing the methylation pattern of ncRNA is still a challenging task. In this chapter, we (1) introduced a strategy of constructing DNA methylation profiles for ncRNAs by reannotating data of DNA methylation arrays; (2) identified methylation patterns of ncRNAs in cancers by classifying ncRNAs into two categories and three subcategories, according to their promoter methylation patterns in tumors; (3) identified lncRNAs with promoter methylation patterns that were associated with cancer status, subtype, or prognosis fo...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Zhi H, Li Y, Wang L Tags: Adv Exp Med Biol Source Type: research

Computationally Modeling ncRNA-ncRNA Crosstalk.
Abstract Our understanding of complex gene regulatory networks have been improved by the discovery of ncRNA-ncRNA crosstalk in normal and disease-specific physiological conditions. Previous studies have proposed numerous approaches for constructing ncRNA-ncRNA networks via ncRNA-mRNA regulation, functional information, or phenomics alone, or by combining heterogeneous data. Furthermore, it has been shown that ncRNA-ncRNA crosstalk can be rewired in different tissues or specific diseases. Therefore, it is necessary to integrate transcriptome data to construct context-specific ncRNA-ncRNA networks. In this chapter, ...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Xu J, Bai J, Xiao J Tags: Adv Exp Med Biol Source Type: research

Imatinib rechallenge in patients with advanced gastrointestinal stromal tumors following progression with imatinib, sunitinib and regorafenib.
Conclusions: Our retrospective data confirm that imatinib rechallenge is a reasonable option in advanced GIST. The prognostic value of the specific KIT mutations was confirmed in our series. PMID: 30181783 [PubMed] (Source: Adv Data)
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Vincenzi B, Nannini M, Badalamenti G, Grignani G, Fumagalli E, Gasperoni S, D'Ambrosio L, Incorvaia L, Stellato M, Spalato Ceruso M, Napolitano A, Valeri S, Santini D, Tonini G, Casali PG, Dei Tos AP, Pantaleo MA Tags: Ther Adv Med Oncol Source Type: research

Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology.
ris F Abstract Over the last decades, the concept of precision medicine has dramatically renewed the field of medical oncology; the introduction of patient-tailored therapies has significantly improved all measurable outcomes. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of the detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Many technical hurdles have been resolved thanks to newly developed techniques and next-generation sequencing analyses...
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Palmirotta R, Lovero D, Cafforio P, Felici C, Mannavola F, Pellè E, Quaresmini D, Tucci M, Silvestris F Tags: Ther Adv Med Oncol Source Type: research

The clinical significance of hyperglycemia in nondiabetic critically ill multiple trauma patients.
In this study we investigated the clinical significance of hyperglycemia related to new episodes of ventilator-associated pneumonia in nondiabetic critically ill multiple trauma intensive care unit patients. Materials and Methods: We analyzed the clinical data of 202 critically ill multiple trauma patients with no history of previous diabetes who developed a new ventilator-associated pneumonia episode during their intensive care unit stay. We used a time-from-event analysis method to assess whether acute changes in blood glucose levels that occurred prior to the onset of ventilator-associated pneumonia episodes had a ...
Source: Adv Data - September 7, 2018 Category: Epidemiology Authors: Koyfman L, Brotfain E, Frank D, Bichovsky Y, Kovalenko I, Benjamin Y, Borer A, Friger M, Klein M Tags: Ther Adv Endocrinol Metab Source Type: research

Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution.
Abstract Hyperspectral imaging (HSI) systems have the potential to retrieve in vivo hemodynamic and metabolic signals from the exposed cerebral cortex. The use of multiple narrow wavelength bands in the near infrared (NIR) range theoretically allows not only to image brain tissue oxygenation and hemodynamics via mapping of hemoglobin concentration changes, but also to directly quantify cerebral metabolism via measurement of the redox states of mitochondrial cytochrome-c-oxidase (CCO). The aim of this study is to assess the possibility of performing hyperspectral imaging of in vivo cerebral oxyhemoglobin (HbO2), de...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Giannoni L, Lange F, Davies AL, Dua A, Gustavson B, Smith KJ, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research

Changes in Spinal Muscle Oxygenation and Perfusion During the Biering-S ørensen Test: Preliminary Results of a Study Employing NIRS-Based Muscle Oximetry.
Changes in Spinal Muscle Oxygenation and Perfusion During the Biering-Sørensen Test: Preliminary Results of a Study Employing NIRS-Based Muscle Oximetry. Adv Exp Med Biol. 2018;1072:103-109 Authors: Vrana A, Scholkmann F, Wirth B, Flueck M, Humphreys BK Abstract Low back pain (LBP) is suggested to be related to deconditioning of back muscles by a decreased capacity for hyperemia in exercising muscles. However, only inconsistent evidence exists regarding back muscle perfusion and oxygen saturation in healthy subjects and patients suffering from (chronic) LBP. AIM: We measured muscle perfusi...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Vrana A, Scholkmann F, Wirth B, Flueck M, Humphreys BK Tags: Adv Exp Med Biol Source Type: research

Trail Making Test Induces Prefrontal Cortex Activation as Revealed by a cw Wearable-Wireless fNIRS/DOT Imager.
Abstract The recent availability of low-cost wearable continuous wave (cw) fNIRS/DOT devices is supposed to revolutionize cortical human brain mapping in the real-life. Ecological paper-pencil tests, as the Trail Making Test (TMT), are commonly used in neuropsychological clinics but its neural substrates are not completely understood. The aim of this study was to map, using a new cw wearable fNIRS/DOT imager (NIRSIT), the prefrontal cortex (PFC) hemodynamic response in healthy subjects while performing the TMT. The ANOVA analysis, performed on the 60 region-DOT data, shows a significant task-related activation of ...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Lancia S, Choi J, Baek J, Mammarella S, Bianco D, Quaresima V, Ferrari M Tags: Adv Exp Med Biol Source Type: research

Septic-Induced microRNA Expression Modulations Are Linked to Angiogenesis, Vasomotion, and Hypoxia-Induced Processes.
Abstract Sepsis is an exaggerated immune reaction to an infection, which leads to organ dysfunction especially circulatory failure. This is based on cellular processes, which are regulated by post-transcriptional gene expression modulations including microRNAs (miRNAs). In order to elucidate the role miRNAs play in septic processes, monocytes and endothelial cells were grown in an inflammatory milieu. In addition, aortas from septic mice were investigated. Expression of miRNAs was analysed by both next generation sequencing (NGS) and NanoString technology, and miRNA targets were identified by in silico analysis. C...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Schmidt B, Roessler C, Schumann J Tags: Adv Exp Med Biol Source Type: research

Analysis of Aortic Remodeling and Stiffness in Patients with Obstructive Sleep Apnea Syndrome: Preliminary Results.
cca A Abstract Obstructive sleep apnea (OSA) is a well-known risk factor for cardiovascular diseases. Several studies have shown that OSA is associated with vessel remodeling, but few studies have examined aorta. AIM: to analyse aortic remodelling in OSA. METHODS: Thirty consecutive OSA patients (22 males and 8 females, aged 58.5 ± 13.2 years) were studied. All patients underwent a morning blood gas analysis, a full cardiorespiratory evaluation, including nocturnal polygraphy and echocardiography, that assessed aortic root diameter (ARD) and aortic stiffness index (ASI). Patients were grouped...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Cicco S, Castellana G, Marra L, Dragonieri S, Carratù P, Ranieri G, Resta O, Vacca A Tags: Adv Exp Med Biol Source Type: research

Hyperbaric Oxygen Therapy in Necrotizing Soft Tissue Infections: A Retrospective Study.
This study considers the success of treatment as a result of complying with optimal therapy. In a contribution to establish coverage use and an inventory of hyperbaric chambers, we also aim to create a national case register, so that patients do not have to depend on long and risky transportations. PMID: 30178356 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Steiner T, Seiffart A, Schumann J, Bucher M Tags: Adv Exp Med Biol Source Type: research

Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET.
Abstract Neuronal activity causes changes in both cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF). Since the relationship between tissue oxygenation and regional CBF (rCBF) during exercise has not been elucidated, we compared the data obtained using near-infrared spectroscopy (NIRS) and rCBF examined using positron emission tomography (PET). Participants in this study comprised 26 healthy young men. Changes in concentration of oxygenated hemoglobin (ΔO2Hb) and deoxygenated hemoglobin (ΔHHb) in the prefrontal cortex (PFC) were measured using NIRS continuously during a 15-min bout...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Hiura M, Nariai T, Takahashi K, Muta A, Sakata M, Ishibashi K, Toyohara J, Wagatsuma K, Tago T, Ishii K, Maehara T Tags: Adv Exp Med Biol Source Type: research

Mucine-1 Is Related to Cell-Mediated Immunoexpression and Blood Pressure in Pulmonary Artery in Pulmonary Arterial Hypertension (PAH): Preliminary Results.
CONCLUSIONS: These preliminary data show a possible mechanism of immune stimulation in PAH patients. This may imply an association between lung parenchyma, immunity and increase in vascular resistance. Additional studies are required to confirm these findings. PMID: 30178358 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Cicco S, Leone P, Racanelli V, Vacca A Tags: Adv Exp Med Biol Source Type: research

The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability.
CONCLUSION: The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability. PMID: 30178359 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Liu TC, Tang XM, Duan R, Ma L, Zhu L, Zhang QG Tags: Adv Exp Med Biol Source Type: research

Investigation of Confounding Factors in Measuring Tissue Saturation with NIRS Spatially Resolved Spectroscopy.
Abstract Performing absolute measurements of tissue saturation of the brain with near-infrared spectroscopy (NIRS) is a clinically desirable brain monitoring tool. Tissue oxygenation index (TOI) is an indicator of absolute tissue mixed arterial and venous oxygen saturation, and can be calculated using a NIRS technique called spatially resolved spectroscopy (SRS). SRS instruments measure the change of light attenuation with distance by using multiple light source-detector distances at two or more wavelengths. The aim of the study is to use broadband NIRS SRS data to investigate the effects on the calculation of TOI...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Kovacsova Z, Bale G, Mitra S, de Roever I, Meek J, Robertson N, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research

ABroAD: A Machine Learning Based Approach to Detect Broadband NIRS Artefacts.
Abstract Artefacts are a common and unwanted aspect of any measurement process, especially in a clinical environment, with multiple causes such as environmental changes or motion. In near-infrared spectroscopy (NIRS), there are several existing methods that can be used to identify and remove artefacts to improve the quality of collected data.We have developed a novel Automatic Broadband Artefact Detection (ABroAD) process, using machine learning methods alongside broadband NIRS data to detect common measurement artefacts using the broadband intensity spectrum. Data were collected from eight subjects, using a broad...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Russell-Buckland J, Bale G, de Roever I, Tachtsidis I Tags: Adv Exp Med Biol Source Type: research

Absolute Values of Optical Properties ( μa, μ΄s, μeff and DPF) of Human Head Tissue: Dependence on Head Region and Individual.
CONCLUSION: Our analysis demonstrates that all optical head tissue properties (μa, [Formula: see text], μeff and DPF) were dependent on the head region, individual subject and age. The optical properties of the head are like a 'fingerprint' for the individual subject. Assuming constant optical properties for the whole head should be carefully reconsidered. PMID: 30178366 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Scholkmann F, Zohdi H, Nasseri N, Wolf U Tags: Adv Exp Med Biol Source Type: research

Long-Term Changes in Optical Properties ( μa, μ's, μeff and DPF) of Human Head Tissue During Functional Neuroimaging Experiments.
Long-Term Changes in Optical Properties (μa, μ's, μeff and DPF) of Human Head Tissue During Functional Neuroimaging Experiments. Adv Exp Med Biol. 2018;1072:331-337 Authors: Zohdi H, Scholkmann F, Nasseri N, Wolf U Abstract Frequency-domain near-infrared spectroscopy (FD-NIRS) enables to measure absolute optical properties (i.e. the absorption coefficient, μa, and the reduced scattering coefficient, [Formula: see text]) of the brain tissue. The aim of this study was to investigate how the optical properties changed during the course of a functional NIRS experiment. The analyzed dataset com...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Zohdi H, Scholkmann F, Nasseri N, Wolf U Tags: Adv Exp Med Biol Source Type: research

A New Method Based on Virtual Fluence Detectors and Software Toolbox for Handheld Spectral Optoacoustic Tomography.
jos S Abstract A minimal setup for optoacoustic (OA) imaging requires an ultrasound probe and a pulsed laser. Such a system is capable of imaging small blood vessels and is sensitive to variations in their oxygen saturation. However, absolute oxygenation values cannot be obtained without a proper correction for the varying light fluence resulting from the optical attenuation in the surrounding tissue. Other techniques, such as near-infrared optical tomography (NIROT) can be employed to assist OA imaging for fluence compensation. In this paper, we propose using blood vessels as virtual fluence detectors (VD), which...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Jiang J, Kalyanov A, Ahnen L, Lindner S, Di Costanzo Mata A, Wolf M, Sánchez Majos S Tags: Adv Exp Med Biol Source Type: research

Polyunsaturated Fatty Acids Induce ROS Synthesis in Microvascular Endothelial Cells.
Abstract In sepsis, endothelial dysfunction is a crucial driver known to limit the survival rate of affected patients. For this, ROS-mediated signaling plays an important role in endothelial communication and functionality. In the management of sepsis, polyunsaturated fatty acids (PUFA) have received increasing attention regarding their anti-inflammatory potential neglecting the oxidative properties of these substances. Therefore, in the present study we examined the capacity of PUFA to interfere with the expression of major ROS-producing enzymes, as well as endothelial ROS production itself. The human microvascul...
Source: Adv Data - September 5, 2018 Category: Epidemiology Authors: Trommer S, Leimert A, Bucher M, Schumann J Tags: Adv Exp Med Biol Source Type: research

Personal Oral Infection Control, Low Birthweight, and Preterm Births in Appalachia West Virginia: A Cross-Sectional Study.
Conclusion: There is a need to identify interventions that will benefit pregnant women so that their pregnancies result in healthy pregnancy outcomes. PMID: 30174960 [PubMed] (Source: Adv Data)
Source: Adv Data - September 4, 2018 Category: Epidemiology Authors: Wiener RC, Waters C Tags: Adv Prev Med Source Type: research

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus-Specific Primer Panels.
In this study, we have developed a computational pipeline for designing the oligonucleotides capable of covering a significant number of known viruses within various taxonomic orders, as well as their novel variants. We have subsequently designed a genus-specific oligonucleotide panel for targeted enrichment of viral nucleic acids in biological material and demonstrated the possibility of its application for virus detection in bird samples. We have tested our panel using a number of collected samples and have observed superior efficiency in the detection and identification of viral pathogens. Since a reliable, bioinformati...
Source: Adv Data - September 1, 2018 Category: Epidemiology Authors: Ayginin AA, Pimkina EV, Matsvay AD, Speranskaya AS, Safonova MV, Blinova EA, Artyushin IV, Dedkov VG, Shipulin GA, Khafizov K Tags: Adv Virol Source Type: research

Increasing trend in admission rates and costs for acute diverticulitis during 2005-2015: real-life data from the Abruzzo Region.
Conclusion: During the last decade, in the Abruzzo Region, the HRs for diverticulitis and their costs increased significantly, mainly due to disease complications. Further studies are needed to explore strategies to prevent complications and to realise cost-saving policies. PMID: 30159036 [PubMed] (Source: Adv Data)
Source: Adv Data - September 1, 2018 Category: Epidemiology Authors: Cammarota S, Cargiolli M, Andreozzi P, Toraldo B, Citarella A, Flacco ME, Binda GA, Annibale B, Manzoli L, Cuomo R Tags: Therap Adv Gastroenterol Source Type: research

Assessing Pressure Injury Knowledge Using the Pieper-Zulkowski Pressure Ulcer Knowledge Test.
CONCLUSIONS: Measuring knowledge before and after educational intervention should be considered to determine whether knowledge deficits are corrected. This methodology reinforced the adult learning theory and to help participants realize their own knowledge deficits. The PZ-PUKT may prove a valuable nonthreatening instrument for adult learners to self-identify, self-learn, and self-correct knowledge according to the best new evidence as it becomes available. These findings documented that this interactive, educational intervention did improve the percentage of correct pressure injury knowledge concepts for this group in al...
Source: Adv Data - August 24, 2018 Category: Epidemiology Authors: Delmore B, Ayello EA, Smart H, Sibbald RG Tags: Adv Skin Wound Care Source Type: research

The Diabetic Foot Amputation Decision-Making Process.
CONCLUSIONS: After understanding the patients' decision-making process regarding amputation, healthcare providers should be encouraged to empathize with such patients. Further, providers should respect the patients' and families' decision and provide them with necessary care. Future research should explore professional perspective and family members' care process for amputees to understand the decision-making process of patients who require amputation. PMID: 30134277 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - August 24, 2018 Category: Epidemiology Authors: Wang SY, Liu JF, Huang YP, Chang YY Tags: Adv Skin Wound Care Source Type: research

Ureases: Historical aspects, catalytic, and non-catalytic properties - A review.
Abstract Urease (urea amidohydrolase, EC 3.5.1.5) is a nickel-containing enzyme produced by plants, fungi, and bacteria that catalyzes the hydrolysis of urea into ammonia and carbamate. Urease is of historical importance in Biochemistry as it was the first enzyme ever to be crystallized (1926). Finding nickel in urease's active site (1975) was the first indication of a biological role for this metal. In this review, historical and structural features, kinetics aspects, activation of the metallocenter and inhibitors of the urea hydrolyzing activity of ureases are discussed. The review also deals with the non-enzyma...
Source: Adv Data - August 12, 2018 Category: Epidemiology Authors: Kappaun K, Piovesan AR, Carlini CR, Ligabue-Braun R Tags: J Adv Res Source Type: research

Direct oral anticoagulants for stroke prevention in atrial fibrillation: treatment outcomes and dosing in special populations.
CONCLUSIONS: Overall, results of secondary analyses indicate that the recommended dosing strategy for each of the DOACs produces a consistent anticoagulant effect across a diverse patient population, including those at increased risk of stroke or bleeding. PMID: 30081727 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - August 9, 2018 Category: Epidemiology Authors: Stacy ZA, Richter SK Tags: Ther Adv Cardiovasc Dis Source Type: research

Seasonal and spatial dynamics of enteric viruses in wastewater and in riverine and estuarine receiving waters.
In this study we used carefully validated methods to monitor enteric viruses, namely adenovirus (AdV), JC polyomavirus (JCV), noroviruses (NoVs), sapovirus (SaV) and hepatitis A and E viruses (HAV and HEV) from wastewater source to beaches and shellfish beds. Wastewater influent and effluent, surface water, sediment and shellfish samples were collected in the Conwy catchment (North Wales, UK) once a month for one year. High concentrations of AdV and JCV were found in the majority of samples, and no seasonal patterns were observed. No HAV and HEV were detected and no related illnesses were reported in the area during the pe...
Source: Adv Data - June 16, 2018 Category: Epidemiology Authors: Farkas K, Cooper DM, McDonald JE, Malham SK, de Rougemont A, Jones DL Tags: Sci Total Environ Source Type: research

Five-year outcome and predictors of success after second-generation cryoballoon ablation for treatment of symptomatic atrial fibrillation.
CONCLUSIONS: Sinus rhythm was maintained in a substantial proportion of patients even 5 years after CB-Adv ablation. Patients with a non-enlarged left atrium without diabetes had the best outcome. PMID: 29887425 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - June 13, 2018 Category: Epidemiology Authors: Akkaya E, Berkowitsch A, Zaltsberg S, Greiss H, Hamm CW, Sperzel J, Kuniss M, Neumann T Tags: Int J Cardiol Source Type: research

The NURSING-Positive Recruitment Arabic Model (NURS-P.R.A.M.): A Mixed Methods Study.
CONCLUSION: The study findings reflect certain issues similar to the core international literature on nursing recruitment, however there are fundamental issues particular to the Arab region, which must be included in the development of a nursing recruitment strategy for Arabic nursing. This article is protected by copyright. All rights reserved. PMID: 29893428 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Tawash E, Cowman S Tags: J Adv Nurs Source Type: research

Person-centred pain management for the patient with acute abdominal pain: an ethnography informed by the Fundamentals of Care framework.
CONCLUSIONS: Person-centred pain management requires an organization where patients and practitioners share their knowledge of pain and pain management as true partners. Leaders and practitioners should make small behavioural changes to enable the crucial positive experience of pain management. This article is protected by copyright. All rights reserved. PMID: 29893491 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Avallin T, Muntlin Athlin Å, Sorensen EE, Kitson A, Björck M, Jangland E Tags: J Adv Nurs Source Type: research

The effect of preparation strategies, qualification and professional background on clinical nurse educator confidence.
CONCLUSIONS: This study identifies several preparation strategies that significantly enhance clinical educator confidence and readiness for their complex role. These preparation strategies drawn from the Vietnamese context, provide important examples for the wider nursing community to consider. This article is protected by copyright. All rights reserved. PMID: 29893505 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - June 12, 2018 Category: Epidemiology Authors: Nguyen VNB, Forbes H, Mohebbi M, Duke M Tags: J Adv Nurs Source Type: research

Utilization of initial chemotherapy for newly diagnosed acute myeloid leukemia in the United States.
Abstract The use of chemotherapy in patients with acute myeloid leukemia (AML) is associated with survival benefits and alleviation of symptoms related to AML. Prior studies have demonstrated a lower receipt of chemotherapy with increasing age and comorbidities. We hypothesized that socioeconomic and health system factors also determine the use of chemotherapy. We included 61 775 adults with AML diagnosed between 2003 and 2011 from the National Cancer Database, and performed a multivariable logistic regression model to determine the association between receipt of chemotherapy and several factors. A total of...
Source: Adv Data - June 9, 2018 Category: Epidemiology Authors: Bhatt VR, Shostrom V, Gundabolu K, Armitage JO Tags: Blood Adv Source Type: research

Safety and immunogenicity of conjugate quadrivalent meningococcal vaccination after hematopoietic cell transplantation.
Abstract Immunization with the conjugated quadrivalent (serogroups A, C, Y, and W-135) meningococcal vaccine (MCV4) after hematopoietic cell transplantation (HCT) is recommended. However, immune responses to MCV4 have not been prospectively studied after HCT. We conducted a vaccine response study among 67 adults who received 1 MCV4 dose a year after autologous or allogeneic HCT from January to September 2014. Pre- and postvaccination serogroup serum bactericidal antibody (SBA) titers were measured a median of 57 days after vaccination. Serogroup-specific responses were defined as a fourfold increase in SBA titer w...
Source: Adv Data - June 8, 2018 Category: Epidemiology Authors: Cheng MP, Pandit A, Antin JH, Walsh SR, Huynh D, Ghobrial IM, Baden LR, Marty FM, Issa NC Tags: Blood Adv Source Type: research

In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL.
Abstract Despite the addition of tyrosine kinase inhibitors (TKIs) to the treatment of patients with BCR-ABL1+ B-cell precursor acute lymphoblastic leukemia (BCR-ABL1+ BCP-ALL), relapse both with and without BCR-ABL1 mutations is a persistent clinical problem. To identify BCR-ABL1-independent genetic mediators of response to the TKI dasatinib, we performed in vivo and in vitro RNA interference (RNAi) screens in a transplantable syngeneic mouse model of BCR-ABL1+ BCP-ALL. By using a novel combination of a longitudinal screen design and independent component analysis of screening data, we identified hairpins that ha...
Source: Adv Data - June 3, 2018 Category: Epidemiology Authors: Fiedler ERC, Bhutkar A, Lawler E, Besada R, Hemann MT Tags: Blood Adv Source Type: research

Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita.
Abstract Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome and the prototypic telomere biology disorder (TBD). Leukocyte telomere length (TL) less than the first percentile for age, measured by flow cytometry with in situ hybridization (flow FISH), is diagnostic of DC. Androgens are a therapeutic option for DC/TBD-associated bone marrow failure (BMF). One report has shown an apparent increase in TL in patients while on treatment with the attenuated androgen danazol. The aim of this study was to compare TL over time in 10 androgen-treated and 16 untreated patients with DC. All subjects were e...
Source: Adv Data - June 3, 2018 Category: Epidemiology Authors: Khincha PP, Bertuch AA, Gadalla SM, Giri N, Alter BP, Savage SA Tags: Blood Adv Source Type: research

Related donor transplants: has posttransplantation cyclophosphamide nullified the detrimental effect of HLA mismatch?
Leukemia Working Party of the European Society for Blood and Marrow Transplant and the Center for International Blood and Marrow Transplant Research Abstract We sought to identify whether posttransplantation cyclophosphamide (PT-Cy) reduces or eliminates the detrimental impact of HLA mismatching on outcomes of HLA-haploidentical related donor transplantation for acute leukemia. Data from 2143 donor-recipient pairs (n = 218 haploidentical sibling; n = 218 offspring; n = 1707 HLA-matched sibling) with acute myeloid or lymphoblastic leukemia were studied. All received a calcineurin inhibitor for graft-versus-host dis...
Source: Adv Data - May 30, 2018 Category: Epidemiology Authors: Robinson TM, Fuchs EJ, Zhang MJ, St Martin A, Labopin M, Keesler DA, Blaise D, Bashey A, Bourhis JH, Ciceri F, Ciurea SO, Devine SM, Mohty M, McCurdy SR, Milpied N, McNiece IK, Rocha V, Romee R, Socie G, Yakoub-Agha I, Soiffer RJ, Eapen M, Nagler A, Acute Tags: Blood Adv Source Type: research

Identification of patients with hemoglobin SS/S β0 thalassemia disease and pain crises within electronic health records.
This study demonstrates the feasibility to accurately identify patients with specific types of SCD and pain crises within an EHR. PMID: 29792312 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - May 26, 2018 Category: Epidemiology Authors: Singh A, Mora J, Panepinto JA Tags: Blood Adv Source Type: research

Prevalence and Analysis of Medical Device-Related Pressure Injuries: Results from the International Pressure Ulcer Prevalence Survey.
This study is a retrospective analysis of the 2016 International Pressure Ulcer Prevalence data. Data were limited to US and Canadian facilities. Facilities included acute care, long-term care, rehabilitation, long-term acute care hospitals, and hospice. Analysis included 102,865 adult patients; 99,876 had complete data and were the focus of the analysis and are reported in the results below. RESULTS: The overall PI prevalence was 7.2% (n = 7189), and the facility-acquired prevalence was 3.1% (n = 3113). The prevalence of MDR PIs was 0.60% (n = 601), which included both mucosal and nonmucosal MDR PIs. In this study, 7...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Kayser SA, VanGilder CA, Ayello EA, Lachenbruch C Tags: Adv Skin Wound Care Source Type: research

NGSPanPipe: A Pipeline for Pan-genome Identification in Microbial Strains from Experimental Reads.
Abstract Recent advancements in sequencing technologies have decreased both time span and cost for sequencing the whole bacterial genome. High-throughput Next-Generation Sequencing (NGS) technology has led to the generation of enormous data concerning microbial populations publically available across various repositories. As a consequence, it has become possible to study and compare the genomes of different bacterial strains within a species or genus in terms of evolution, ecology and diversity. Studying the pan-genome provides insights into deciphering microevolution, global composition and diversity in virulence...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Kulsum U, Kapil A, Singh H, Kaur P Tags: Adv Exp Med Biol Source Type: research

Characterization and Antimicrobial Property of Some Heavy Metals Containing Ayurvedic Drugs.
Abstract Ayurvedic medicines are often used in different formulations, the heavy metals, which are generally referred to as being toxic. In this work, we report on the physicochemical characterization and biological activity of some typical Ayurvedic drugs available in the market that contain arsenic, mercury and lead with the emphasis on their antibacterial performance. Among the formulations studied, some of the drugs with 'amorphous' texture (and higher solubility) were found quite active against some bacterial strains whereas the formulations possessing crystalline texture (and low solubility) were found pract...
Source: Adv Data - May 23, 2018 Category: Epidemiology Authors: Panta P, Bhandari TR, Lamsal B, Adhikari R Tags: Adv Exp Med Biol Source Type: research

Health Perception and Adherence with Blood Pressure Control among Rural Chinese Adults with Hypertension.
CONCLUSION: These findings suggest: (a) healthcare providers should focus on educating rural hypertensive adults about healthful diets and behaviors to manage hypertension, especially for those with high household income; (b) knowledge-based health education alone is not adequate; (c) illness perception may not be directly associated with blood pressure and; (d) the Chinese Illness-Perception Questionnaire-Revised and the Inventory of Adherence to Self-management require validation and potential revision for use with rural Chinese populations. This article is protected by copyright. All rights reserved. PMID: 29788548...
Source: Adv Data - May 22, 2018 Category: Epidemiology Authors: Yang L, Taylor E, Winslow B, Pothier P Tags: J Adv Nurs Source Type: research

The characteristics of vessel lining cells in normal spleens and their role in the pathobiology of myelofibrosis.
Abstract The CD34-CD8α+, sinusoid lining, littoral cells (LCs), and CD34+CD8α-, splenic vascular endothelial cells (SVECs) represent 2 distinct cellular types that line the vessels within normal spleens and those of patients with myelofibrosis (MF). To further understand the respective roles of LCs and SVECs, each was purified from normal and MF spleens, cultured, and characterized. Gene expression profiling indicated that LCs were a specialized type of SVEC. LCs possessed a distinct gene expression profile associated with cytoskeleton regulation, cellular interactions, endocytosis, and iron transport....
Source: Adv Data - May 20, 2018 Category: Epidemiology Authors: Qiu J, Salama ME, Hu CS, Li Y, Wang X, Hoffman R Tags: Blood Adv Source Type: research

Epidemiology of AL amyloidosis: a real-world study using US claims data.
This study aimed to provide an up-to-date estimate of prevalence and incidence of AL amyloidosis in the United States. Using claims databases from years 2007 to 2015, adults ≥18 years old with AL amyloidosis were included if they had (1) at least 1 inpatient or 2 outpatient claims consistent with AL amyloidosis and (2) received 1 AL-specific treatment. Prevalence was calculated as the number of AL patients divided by the number of enrollees on June 30th of each calendar year. Incidence was calculated as the number of patients with AL who were disease-free and enrolled with a health plan for 1 year prior, divided by the ...
Source: Adv Data - May 13, 2018 Category: Epidemiology Authors: Quock TP, Yan T, Chang E, Guthrie S, Broder MS Tags: Blood Adv Source Type: research