Perceived Knowledge, Attitudes, and Implementation of Evidence-Based Practice Among Jordanian Nurses in Critical Care Units.
This study aimed at assessing knowledge associated with, attitudes toward, and implementation of EBP among Jordanian registered nurses (RNs) in critical care units. METHOD: A descriptive, correlational, and cross-sectional study was conducted in 5 hospitals: 3 public and 2 private. A convenience sample of 200 RNs was invited. Data were collected using a paper-based and self-administered questionnaire, in 2 sections; the first section was the demographic and contextual characteristics and the second was the Evidence-Based Practice Questionnaire (J Adv Nurs. 2006;53(4):454-458) to measure RNs' knowledge, attitudes, and ...
Source: Adv Data - August 4, 2020 Category: Epidemiology Authors: Salah MA, Abu-Moghli FA Tags: Dimens Crit Care Nurs Source Type: research

The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population.
In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations. PMID: 32566284 [PubMed] (Source: Adv Data)
Source: Adv Data - June 24, 2020 Category: Epidemiology Authors: Saber-Ayad M, Hammoudeh S, Radwan H, Manzoor S, Jabbar H, Wardeh R, Ashraf A, Habib P, Alsamman AM, Hamoudi R Tags: J Adv Res Source Type: research

Implementing Deep Learning Algorithms in Anatomic Pathology Using Open-source Deep Learning Libraries.
This article aims to act as an introductory tutorial to illustrate how to create, train, and evaluate simple artificial learning models (neural networks) on histopathology data sets in the programming language Python using the popular freely available, open-source libraries Keras, TensorFlow, PyTorch, and Detecto. Furthermore, it aims to introduce pathologists to commonly used terms and concepts used in artificial intelligence. PMID: 32541595 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - June 18, 2020 Category: Epidemiology Authors: McAlpine E, Michelow P Tags: Adv Anat Pathol Source Type: research

Efficacy of Incontinence-Associated Dermatitis Intervention for Patients in Intensive Care: An Open-Label Pilot Randomized Controlled Trial.
CONCLUSIONS: This study reports no significant findings between the two groups. Difficulty in recruitment and feasibility issues might be overcome with changes to inclusion criteria and study design. PMID: 32544117 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - June 18, 2020 Category: Epidemiology Authors: Coyer F, Campbell J, Doubrovsky A Tags: Adv Skin Wound Care Source Type: research

Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review.
This article outlines the approach to holistic management of such patients, in a specialized unit, highlighting various practical aspects of wound care to prevent complications such as infection, mucosal and adhesions, and ocular scaring. Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed. Critical Issue...
Source: Adv Data - June 12, 2020 Category: Epidemiology Authors: Charlton OA, Harris V, Phan K, Mewton E, Jackson C, Cooper A Tags: Adv Wound Care (New Rochelle) Source Type: research

Whole-genome sequence of Phellinus gilvus (mulberry Sanghuang) reveals its unique medicinal values.
Abstract Phellinus gilvus (Schwein.) Pat, a species of 'Sanghuang', has been well-documented for various medicinal uses, but the genome information and active constituents are largely unknown. Here, we sequenced the whole-genome of P. gilvus, identified phenylpropanoids as its key anti-cancer components, and deduced their biosynthesis pathways. A 41.11-Mb genome sequence was assembled and the heatmap created with high-throughput chromosome conformation capture techniques data suggested all bins could be clearly divided into 11 pseudochromosomes. Cellular experiments showed that P. gilvus fruiting body was more eff...
Source: Adv Data - May 27, 2020 Category: Epidemiology Authors: Huo J, Zhong S, Du X, Cao Y, Wang W, Sun Y, Tian Y, Zhu J, Chen J, Xuan L, Wu C, Li Y Tags: J Adv Res Source Type: research

A reverse transcriptase-mediated ribosomal RNA depletion (RTR2D) strategy for the cost-effective construction of RNA sequencing libraries.
Abstract RNA sequencing (RNA-seq)-based whole transcriptome analysis (WTA) using ever-evolving next-generation sequencing technologies has become a primary tool for coding and/or noncoding transcriptome profiling. As WTA requires RNA-seq data for both coding and noncoding RNAs, one key step for obtaining high-quality RNA-seq data is to remove ribosomal RNAs, which can be accomplished by using various commercial kits. Nonetheless, an ideal rRNA removal method should be efficient, user-friendly and cost-effective so it can be adapted for homemade RNA-seq library construction. Here, we developed a novel reverse trans...
Source: Adv Data - May 7, 2020 Category: Epidemiology Authors: Zeng Z, Huang B, Wang X, Fan J, Zhang B, Yang L, Feng Y, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Pakvasa M, Wagstaff W, Li AJ, Liu B, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wolf JM, Lee MJ, Huang A, Luu HH, Haydon RC, He TC Tags: J Adv Res Source Type: research

A decision support scheme for beta thalassemia and HbE carrier screening.
Abstract The most effective way to combat β-thalassemias is to prevent the birth of children with thalassemia major. Therefore, a cost-effective screening method is essential to identify β-thalassemia traits (BTT) and differentiate normal individuals from carriers. We considered five hematological parameters to formulate two separate scoring mechanisms, one for BTT detection, and another for joint determination of hemoglobin E (HbE) trait and BTT by employing decision trees, Naïve Bayes classifier, and Artificial neural network frameworks on data collected from the Postgraduate Institute of Medical ...
Source: Adv Data - May 6, 2020 Category: Epidemiology Authors: Das R, Datta S, Kaviraj A, Sanyal SN, Nielsen P, Nielsen I, Sharma P, Sanyal T, Dey K, Saha S Tags: J Adv Res Source Type: research

Double layer MOFs M-ZIF-8@ZIF-67: The adsorption capacity and removal mechanism of fipronil and its metabolites from environmental water and cucumber samples.
This study indicates that M-ZIF-8@ZIF-67 has significant potential in the adsorption and removal of fipronil and its metabolites in water and vegetable samples. PMID: 32337089 [PubMed] (Source: Adv Data)
Source: Adv Data - April 29, 2020 Category: Epidemiology Authors: Li T, Lu M, Gao Y, Huang X, Liu G, Xu D Tags: J Adv Res Source Type: research

The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma.
In this study, we obtained data from public databases, such as the Gene Expression Omnibus, the Cancer Genome Atlas Program, the International Cancer Genome Consortium Data Portal, the ArrayExpress Data Warehouse, and the cBioPortal for Cancer Genomics. We used these data to evaluate the pattern of immune cells infiltration in pancreatic ductal adenocarcinoma (PDAC) tissues. We observed that the levels of M0 macrophages and activated dendritic cells in tumor tissues were significantly higher than that in para-tumor tissues. M0 macrophages, gamma delta T cells and naive CD4 T cells were independent predictive factors of a p...
Source: Adv Data - April 25, 2020 Category: Epidemiology Authors: Xu C, Sui S, Shang Y, Yu Z, Han J, Zhang G, Ntim M, Hu M, Gong P, Chen H, Zhang X Tags: J Adv Res Source Type: research

A high-throughput method for dereplication and assessment of metabolite distribution in Salvia species using LC-MS/MS.
This study proposes a solution to this problem by the optimization of chromatographic separation and mass spectrometry parameters. We report herein a direct and high-throughput strategy for natural product dereplication in five Salvia species using high-resolution ESI-QTOF-MS/MS data. In the present study, we were able to identify a total of forty-seven natural products in crude extracts of five Salvia species using MS/MS fragmentation data. In addition to dereplication of Salvia species, quantitative profiling of twenty-one bioactive constituents of the genus was also performed on an ion trap mass spectrometer. For the qu...
Source: Adv Data - March 29, 2020 Category: Epidemiology Authors: Ul Haq F, Ali A, Akhtar N, Aziz N, Khan MN, Ahmad M, Musharraf SG Tags: J Adv Res Source Type: research

Whole-cell fungal-mediated structural transformation of anabolic drug metenolone acetate into potent anti-inflammatory metabolites.
Abstract Seven new derivatives, 6α-hydroxy-1-methyl-3-oxo-5α-androst-1-en-17-yl acetate (2), 6α,17β-dihydroxy-1-methyl-3-oxo-5α-androst-1-en (3), 7β-hydroxy-1-methyl-3-oxo-5α-androst-1-en-17-yl acetate (4), 15β,20-dihydroxy-1-methyl-3-oxo-5α-androst-1-en-17-yl acetate (5), 15β-hydroxy-1-methyl-3-oxo-5α-androst-1-en-17-yl acetate (6), 12β,17β-dihydroxy-1-methyl-3-oxoandrosta-1,4-dien (11), and 7β,15β,17β-trihydroxy-1-methyl-3-oxo-5α-androst-1-en (14), along with six known metabolites, 17β-hydroxy-1-methyl-3-oxoandrosta...
Source: Adv Data - March 21, 2020 Category: Epidemiology Authors: Siddiqui M, Atia-Tul-Wahab, Jabeen A, Wang Y, Wang W, Atta-Ur-Rahman, Choudhary MI Tags: J Adv Res Source Type: research

Integrated analysis of the proteome and transcriptome in a MCAO mouse model revealed the molecular landscape during stroke progression.
Abstract Strokes usually results in long-term disability and death, and they occur worldwide. Recently, increased research on both on the physiopathological mechanisms and the transcriptome during stroke progression, have highlighted the relationship between stroke progression and immunity, with a special focus on inflammation. Here, we applied proteome analysis to a middle carotid artery occlusion (MCAO) mouse model at 0 h, 6 h, 12 h and 24 h, in which proteome profiling was performed with 23 samples, and 41 differentially expressed proteins (DEPs) were identified. Bioinformatics studies on ou...
Source: Adv Data - March 19, 2020 Category: Epidemiology Authors: Li L, Dong L, Xiao Z, He W, Zhao J, Pan H, Chu B, Cheng J, Wang H Tags: J Adv Res Source Type: research

Development and validation of a nomogram for predicting late-onset sepsis in preterm infants on the basis of thyroid function and other risk factors: Mixed retrospective and prospective cohort study.
This study is a mixed retrospective and prospective cohort study conducted in three centers. Data from January 2014 to December 2017 was used for the development cohort, and data from January 2018 to December 2018 was used for the validation cohort. In the development cohort, we identified the predicting variables of late-onset sepsis in preterm infants, from which a nomogram was obtained. Then we built nomograms, for with and without thyroid function, to predict late-onset sepsis. The nomogram was validated in the validation cohort concerning discrimination and calibration. A total of 1256 and 452 preterm infants were inc...
Source: Adv Data - March 19, 2020 Category: Epidemiology Authors: Huang Y, Yu X, Li W, Li Y, Yang J, Hu Z, Wang Y, Chen P, Li W, Chen Y Tags: J Adv Res Source Type: research

Predicting success in an undergraduate exercise science program using science-based admission courses.
In conclusion, the identification of these courses, related to student success, may provide valuable insight for other Exercise Science-related programs that are considering implementing a program admission policy. PMID: 32108508 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - February 29, 2020 Category: Epidemiology Authors: Esmat TA, Pitts JD Tags: Adv Physiol Educ Source Type: research

Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model.
n M Abstract Functional food defined as dietary supplements that in addition to their nutritional values, can beneficially modulate body functions becomes more and more popular but the reaction of the intestinal microbiota to it is largely unknown. In order to analyse the impact of functional food on the microbiota itself it is necessary to focus on the physiology of the microbiota, which can be assessed in a whole by untargeted metabolomics. Obtaining a detailed description of the gut microbiota reaction to food ingredients can be a key to understand how these organisms regulate and bioprocess many of these food ...
Source: Adv Data - February 20, 2020 Category: Epidemiology Authors: Farag MA, Abdelwareth A, Sallam IE, El Shorbagi M, Jehmlich N, Fritz-Wallace K, Serena Schäpe S, Rolle-Kampczyk U, Ehrlich A, Wessjohann LA, von Bergen M Tags: J Adv Res Source Type: research

Pressure Ulcer Risk Factors in Persons with Mobility-Related Disabilities.
CONCLUSIONS: The results indicate that, although persons with disabilities can exhibit a wide functional range, they remain at risk of PUs and should be evaluated for proper preventive measures, including support surfaces and wheelchair cushions. PMID: 32058440 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - February 16, 2020 Category: Epidemiology Authors: Sprigle S, McNair D, Sonenblum S Tags: Adv Skin Wound Care Source Type: research

Skin Biomechanics and miRNA Expression Following Chronic UVB Irradiation.
Conclusion: The data suggest that UVB alters miR-34 family expression in skin, in addition to dysregulating collagen structure with subsequent reductions in strength and elasticity. miRNAs may play a pivotal role in regulating extracellular matrix deposition and skin biomechanics following chronic UVB exposure, and thus may be a possible target for therapeutic development. However, additional studies are needed to directly probe the link between UVB exposure, miRNA production, and skin biomechanics. PMID: 31993250 [PubMed] (Source: Adv Data)
Source: Adv Data - January 30, 2020 Category: Epidemiology Authors: Blackstone BN, Wilgus TA, Roy S, Wulff BC, Powell HM Tags: Adv Wound Care (New Rochelle) Source Type: research

Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress.
Abstract The Arabian camel is the largest known mammal that can survive in severe hot climatic conditions. We provide the molecular explanation for the thermotolerance of camel granulosa somatic cells after exposure to 45 °C for 2 (acute heat shock) or 20 h (chronic heat shock). The common features of the cellular responses to acute heat stress were the increase of heat shock proteins and DNA repair enzymes expression. Actin polymerization and Rho signaling were critically activated as a cellular defense against heat shock. Cells exposed to chronic heat shock showed altered cell architecture with a d...
Source: Adv Data - January 24, 2020 Category: Epidemiology Authors: Saadeldin IM, Swelum AA, Elsafadi M, Mahmood A, Osama A, Shikshaky H, Alfayez M, Alowaimer AN, Magdeldin S Tags: J Adv Res Source Type: research

Removal and recovery of U(VI) from aqueous effluents by flax fiber: Adsorption, desorption and batch adsorber proposal.
Abstract Flax fiber (Linen fiber), a valuable and inexpensive material was used as sorbent material in the uptake of uranium ion for the safe disposal of liquid effluent. Flax fibers were characterized using BET, XRD, TGA, DTA and FTIR analyses, and the results confirmed the ability of flax fiber to adsorb uranium. The removal efficiency reached 94.50% at pH 4, 1.2 g adsorbent dose and 100 min in batch technique. Adsorption results were fitted well to the Langmuir isotherm. The recovery of U (VI) to form yellow cake was investigated by precipitation using NH4OH (33%). The results show that flax fibers are an a...
Source: Adv Data - January 24, 2020 Category: Epidemiology Authors: Abutaleb A, Tayeb AM, Mahmoud MA, Daher AM, Desouky OA, Bakather OY, Farouq R Tags: J Adv Res Source Type: research

Gut butyrate-producing organisms correlate to Placenta Specific 8 protein: Importance to colorectal cancer progression.
Abstract Tumor metastasis or recurrence often occurs in patients with curative resection of colorectal cancer (CRC). Placental-specific 8 (PLAC8), which has increased expression in stool, may be associated with CRC recurrence. Insights into the role of PLAC8 in CRC recurrence and its clinical significance may support to develop strategies for preventing CRC recurrence and deterioration. Clinical tissues, cell and animal models were used to clarify the roles of PLAC8 in CRC tumorigenesis, invasion, and migration. Next-generation sequencing of 16S ribosomal DNA has been used to assess the gut microbiota in stool of ...
Source: Adv Data - January 22, 2020 Category: Epidemiology Authors: Huang CC, Shen MH, Chen SK, Yang SH, Liu CY, Guo JW, Chang KW, Huang CJ Tags: J Adv Res Source Type: research

Using lectures to identify student misconceptions: a study on the paradoxical effects of hyperkalemia on vascular smooth muscle.
Abstract Medical students have difficulty understanding the mechanisms underlying hyperkalemia-mediated local control of blood flow. Such control mechanisms are crucial in the brain, kidney, and skeletal muscle vasculature. We aimed to identify medical students' misconceptions via assessment of students' in-class knowledge and, subsequently, improve future teaching of this concept. In-class polling was performed with the TurningPoint clicker response system (n = 860) to gauge students' understanding of three physiological concepts related to hyperkalemia: membrane potential (Vm), conductance, and smooth muscle res...
Source: Adv Data - December 11, 2019 Category: Epidemiology Authors: Bordes SJ, Gandhi J, Bauer B, Protas M, Solomon N, Bogdan L, Brummund D, Bass B, Clunes M, Murray IVJ Tags: Adv Physiol Educ Source Type: research

Drinking water and sanitation conditions are associated with the risk of malaria among children under five years old in sub-Saharan Africa: A logistic regression model analysis of national survey data.
Abstract Current efforts for the prevention of malaria have resulted in notable reductions in the global malaria burden; however, they are not enough. Good hygiene is universally considered one of the most efficacious and straightforward measures to prevent disease transmission. This work analyzed whether improved drinking water and sanitation (WS) conditions were associated with a decreased risk of malaria infection. Data were acquired through surveys published between 2006 and 2018 from the Demographic and Health Program in sub-Saharan Africa (SSA). Multiple logistic regression was used for each national survey ...
Source: Adv Data - October 25, 2019 Category: Epidemiology Authors: Yang D, He Y, Wu B, Deng Y, Li M, Yang Q, Huang L, Cao Y, Liu Y Tags: J Adv Res Source Type: research

Walking on the Moon: A randomized clinical trial on the role of lower body positive pressure treadmill training in post-stroke gait impairment.
i P, Naro A Abstract Body weight-supported treadmill training (BWSTT) can be usefully employed to facilitate gait recovery in patients with neurological injuries. Specifically, lower body positive pressure support system (LBPPSS) decreases weight-bearing and ground reaction forces with potentially positive effects on qualitative gait indices. However, which gait features are being shaped by LBPPSS in post-stroke patients is yet poorly predictable. A pilot study on the effects of LBPPSS on qualitative and quantitative gait indices was carried out in patients with hemiparesis due to stroke in the chronic phase. Fift...
Source: Adv Data - October 25, 2019 Category: Epidemiology Authors: Calabrò RS, Billeri L, Andronaco VA, Accorinti M, Milardi D, Cannavò A, Aliberti E, Militi A, Bramanti P, Naro A Tags: J Adv Res Source Type: research

Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Abstract Thymic mucoepidermoid carcinoma is a rare tumor that remains poorly characterized and a diagnostic challenge. The aim of this review is to characterize this tumor in a larger cohort of patients using all the available cases in the literature. We systematically searched the PubMed and Scopus database for primary thymic mucoepidermoid carcinoma. A total of 24 studies were included in the final analysis. A total of 41 patients were identified; 23 (56.1%) were male and 18 (43.9%) were female. Mean age was 49.8±21.3 years. Mean tumor size was 7.6±3.5 cm. Twenty (66.7%) were low grade and 8...
Source: Adv Data - October 9, 2019 Category: Epidemiology Authors: Hamza A, Younes AI, Kalhor N Tags: Adv Anat Pathol Source Type: research

Changes in life expectancy for cancer patients over time since diagnosis.
, De Angelis R, Buzzoni C, Capocaccia R, AIRTUM Working Group Abstract The aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patients' entire lives. Cancer patients' LE was calculated by standard period life table methodology using the relative survival of Italian patients diagnosed in population-based cancer registries in 1985-2011 with follow-up to 2013. Data were smoothed using a polynomial model and years of life lost (YLL) were calculated as the difference between patients' LE and t...
Source: Adv Data - September 1, 2019 Category: Epidemiology Authors: Botta L, Dal Maso L, Guzzinati S, Panato C, Gatta G, Trama A, Rugge M, Tagliabue G, Casella C, Caruso B, Michiara M, Ferretti S, Sensi F, Tumino R, Toffolutti F, Russo AG, Caiazzo AL, Mangone L, Mazzucco W, Iacovacci S, Ricci P, Gola G, Candela G, Sardo A Tags: J Adv Res Source Type: research

Genetic programming approach for predicting service life of tunnel structures subject to chloride-induced corrosion.
Abstract A new method for predicting the service life of tunnel structures subject to chloride-induced corrosion using data from real engineering examples and genetic programming (GP) is proposed. As a data-driven method, the new approach can construct explicit expressions of the prediction model. The new method was verified by comparing it with the chloride-ion diffusion model considering eight corrosion influence factors. Moreover, 25 datasets collected from tunnel engineering examples were used to construct the new prediction model considering 17 corrosion influence factors belonged to just one classification o...
Source: Adv Data - August 29, 2019 Category: Epidemiology Authors: Gao W, Chen X, Chen D Tags: J Adv Res Source Type: research

Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells.
In this study, systematic separation and subsequent pharmacological activity studies were carried out to identify cytotoxic natural products from the dried stems of Millettia pachyloba Drake. Five previously undescribed isoflavones, pachyvones A-E; one previously undescribed xanthone, pachythone A; and twenty-two known compounds were obtained. The structures of these compounds were assigned on the basis of 1D/2D NMR data and high-resolution electrospray ionization mass spectroscopy analysis. Preliminary activity screening with HeLa and MCF-7 cells showed that ten compounds (3-5, 9, 12, 17-19, 24, and 25) had potential cyto...
Source: Adv Data - July 26, 2019 Category: Epidemiology Authors: Yan W, Yang J, Tang H, Xue L, Chen K, Wang L, Zhao M, Tang M, Peng A, Long C, Chen X, Ye H, Chen L Tags: J Adv Res Source Type: research

Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival.
ml;dör C, Győrffy B Abstract Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant myeloid disorder in adults. Several gene mutations such as in NPM1 (nucleophosmin 1) are involved in the pathogenesis and progression of AML. The aim of this study was to identify genes whose expression is associated with driver mutations and survival outcome. Genotype data (somatic mutations) and gene expression data including RNA-seq, microarray, and qPCR data were used for the analysis. Multiple datasets were utilized as training sets (GSE6891, TCGA, and GSE1159). ...
Source: Adv Data - July 24, 2019 Category: Epidemiology Authors: Nagy Á, Ősz Á, Budczies J, Krizsán S, Szombath G, Demeter J, Bödör C, Győrffy B Tags: J Adv Res Source Type: research

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer.
Abstract The efficacy of gemcitabine therapy is often insufficient for the treatment of pancreatic cancer. The current study demonstrated that LW6, a chemical inhibitor of hypoxia-inducible factor 1α, is a promising drug for enhancing the chemosensitivity to gemcitabine. LW6 monotherapy and the combination therapy of LW6 plus gemcitabine significantly inhibited cell proliferation and enhanced cell death in pancreatic cancer cells. This combination therapy also significantly reduced the tumor weight in a syngeneic orthotopic pancreatic carcinoma model without causing toxic side effects. In addition, this stud...
Source: Adv Data - June 15, 2019 Category: Epidemiology Authors: Zhang X, Kumstel S, Jiang K, Meng S, Gong P, Vollmar B, Zechner D Tags: J Adv Res Source Type: research

To reveal pharmacological targets and molecular mechanisms of curcumol against interstitial cystitis.
In conclusion, the current bioinformatic data and preliminary findings unravel that the predominant targets of curcumol against IC may be the potential biological markers for screening and treating IC, such as PTK2 molecule. PMID: 31193808 [PubMed] (Source: Adv Data)
Source: Adv Data - June 15, 2019 Category: Epidemiology Authors: Wu K, Wei P, Liu M, Liang X, Su M Tags: J Adv Res Source Type: research

Advanced DNA fingerprint genotyping based on a model developed from real chip electrophoresis data.
This study presents a new approach based on global multiple alignments of bands of all samples, with an adaptive threshold derived from the detailed migration analysis of a large number of real samples. The proposed approach allows the accurate automated analysis of DNA fingerprint similarities for extensive epidemiological studies of bacterial strains, thereby helping to prevent the spread of dangerous microbial infections. PMID: 30788173 [PubMed] (Source: Adv Data)
Source: Adv Data - February 24, 2019 Category: Epidemiology Authors: Skutkova H, Vitek M, Bezdicek M, Brhelova E, Lengerova M Tags: J Adv Res Source Type: research

Boot Camp for Caregivers of Children With Medically Complex Conditions.
Abstract BACKGROUND: The safe transition of children with complex medical conditions who are dependent on technology from hospital to home requires that caregivers receive specialized training from qualified health care professionals. Inadequate caregiver training can lead to discharge delays and hospital readmissions, often resulting in caregiver distress. OBJECTIVE: To determine the effectiveness of a structured boot camp-style predischarge training program for caregivers of pediatric patients with complex medical conditions. METHODS: We conducted a quasi-experimental interventional study to compare ou...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Van Orne J, Branson K, Cazzell M Tags: AACN Adv Crit Care Source Type: research

Reducing Tracheostomy-Related Pressure Injuries.
Abstract An interprofessional team was established to prevent tracheostomy-related acquired pressure injuries. The team performed an in-depth analysis of practice from tracheostomy insertion through postinsertion care. A literature evaluation identified best practices, and a root cause analysis for all tracheostomy-related pressure injury cases identified common causes. Lessons learned from the practice and literature reviews drove care standardization and reduced variation. Preimplementation and postimplementation data were analyzed to determine the effectiveness of improvement interventions. Improvement strategi...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Dixon LM, Mascioli S, Mixell JH, Gillin T, Upchurch CN, Bradley KM Tags: AACN Adv Crit Care Source Type: research

Pericyte Secretome.
Abstract The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of peric...
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Gaceb A, Paul G Tags: Adv Exp Med Biol Source Type: research

Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure.
Conclusions: These data can help inform healthcare professionals and women with MS exposed to fingolimod during conception. PMID: 30542374 [PubMed] (Source: Adv Data)
Source: Adv Data - December 14, 2018 Category: Epidemiology Authors: Geissbühler Y, Vile J, Koren G, Guennec M, Butzkueven H, Tilson H, MacDonald TM, Hellwig K Tags: Ther Adv Neurol Disord Source Type: research

Protein Localization and Interaction Studies in Plants: Toward Defining Complete Proteomes by Visualization.
Abstract Protein interaction and localization studies in plants are a fundamental component of achieving mechanistic understanding of virus:plant interactions at the systems level. Many such studies are conducted using transient expression assays in leaves of Nicotiana benthamiana, the most widely used experimental plant host in virology, examined by laser-scanning confocal microscopy. This chapter provides a workflow for protein interaction and localization experiments, with particular attention to the many control and supporting assays that may also need to be performed. Basic principles of microscopy are introd...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Goodin MM Tags: Adv Virus Res Source Type: research

Hosts and Sources of Endemic Human Coronaviruses.
Abstract The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in major livestock species while primordial associations for all four viruses may have existed with bats and rodents. HCoV-NL63 and -229E ...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Corman VM, Muth D, Niemeyer D, Drosten C Tags: Adv Virus Res Source Type: research

Changing Role of Wild Birds in the Epidemiology of Avian Influenza A Viruses.
Abstract Waterbirds are the main reservoir for low pathogenic avian influenza A viruses (LPAIV), from which occasional spillover to poultry occurs. When circulating among poultry, LPAIV may become highly pathogenic avian influenza A viruses (HPAIV). In recent years, the epidemiology of HPAIV viruses has changed drastically. HPAIV H5N1 are currently endemic among poultry in a number of countries. In addition, global spread of HPAIV H5Nx viruses has resulted in major outbreaks among wild birds and poultry worldwide. Using data collected during these outbreaks, the role of migratory birds as a vector became increasin...
Source: Adv Data - December 13, 2018 Category: Epidemiology Authors: Bodewes R, Kuiken T Tags: Adv Virus Res Source Type: research

Laparoscopic D2 Gastrectomy for Gastric Cancer: Mid-Term Results and Current Evidence.
CONCLUSION: Laparoscopic gastrectomy can be performed safely with excellent short- and mid-term results. As experience increases, surgical duration is reduced and lymph node count rises. PMID: 30526290 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - December 11, 2018 Category: Epidemiology Authors: Dias AR, Jacob CE, Ramos MFKP, Pereira MA, Szor DJ, Yagi OK, Barchi LC, Ribeiro U, Zilberstein B, Cecconello I Tags: J Laparoendosc Adv Surg Tech A Source Type: research

The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma.
Abstract Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) family proteins. Here, we provide evidence to support pharmacologically targeting IAPs in lymphoma with LCL-161, a small molecule mimetic of the second mitochondria-derived activator of caspases (SMAC). The antitumor effect of LCL-161 was determined using luminescent adenosine triphosphate assays, flow cytometry...
Source: Adv Data - December 11, 2018 Category: Epidemiology Authors: Runckel K, Barth MJ, Mavis C, Gu JJ, Hernandez-Ilizaliturri FJ Tags: Blood Adv Source Type: research

Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.
Abstract The NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 develop severe thrombocytopenia with lethality resulting from neonatal hemorrhage. Recent data in mammals reveal potential differences in embryonic and adult thrombopoiesis. Multiple studies in zebrafish have revealed mechanistic insights into hematopoiesis, although thrombopoiesis has been less studied. Rather than platelets, zebrafish possess thrombocytes, which are nucleated cells with similar functional ...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM, Barrett FG, Stachura DL, Holinstat M, Zon LI, Shavit JA Tags: Blood Adv Source Type: research

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.
Abstract To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared with normal hematopoietic cells. Inhibiting IKBKE, or its close homolog TANK-binding kinase 1 (TBK1), by either short hairpin RNA knockdown or pharmacological compounds, induces apoptosis and reduces the viability of AML cells. Using gene expression profiling and gene set enrichment analysis, we found that IKBKE/TBK1-sensitive AML cell...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Liu S, Marneth AE, Alexe G, Walker SR, Gandler HI, Ye DQ, Labella K, Mathur R, Toniolo PA, Tillgren M, Gokhale PC, Barbie D, Mullally A, Stegmaier K, Frank DA Tags: Blood Adv Source Type: research

Development of a clinical risk score for pain and function following total knee arthroplasty: results from the TRIO study.
Conclusion: We have developed and validated a clinical prediction model that can be used to identify patients at high risk of a poor outcome after TKA. This clinical risk score may be an aid to shared decision-making between patient and clinician. PMID: 30506023 [PubMed] (Source: Adv Data)
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Shim J, Mclernon DJ, Hamilton D, Simpson HA, Beasley M, Macfarlane GJ Tags: Rheumatol Adv Pract Source Type: research

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.
;tze KS Abstract Mesenchymal stromal cells (MSCs) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival, and differentiation of hematopoietic stem/progenitor cells (HSPCs) in the stem cell niche. MSCs are functionally altered in myelodysplastic syndromes (MDS) and exhibit an altered methylome compared with MSCs from healthy controls, thus contributing to disease progression. To determine whether MSCs are amenable to epigenetic therapy and if this affects their function, we examined growth, differentiation, and HSPC-supporting capacity of ex vivo-expanded MS...
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M, Götze KS Tags: Blood Adv Source Type: research

Who are the right teachers for medical clinical students? Investigating stakeholders' opinions using modified Delphi approach.
Conclusion: The results of this study indicated the necessity of forming a teaching team, paying attention to the selection criteria, and planning requirements for assigning responsibilities to the teaching team in accordance with the objectives, programs, and requirements of medical schools, along with using strategies to attract participation and create motivation in the teaching team. PMID: 30519136 [PubMed] (Source: Adv Data)
Source: Adv Data - December 9, 2018 Category: Epidemiology Authors: Shaterjalali M, Yamani N, Changiz T Tags: Adv Med Educ Pract Source Type: research

Acetabular Debonding: An Investigation of Porous Coating Delamination in Hip Resurfacing Arthroplasty.
This study aims to summarize the current understanding of acetabular debonding and to investigate the discrepancy in rate of debonding between two implant systems. Patients and Methods: To elucidate potential causes of debonding, we retrospectively analyzed a single-surgeon cohort of 839 hip resurfacing cases. Specifically, we compared rate of debonding and manufacturing processes between two implant systems. Results: Group 1 experienced significantly more cases of debonding than Group 2 cases (4.0% versus 0.0%, p value
Source: Adv Data - December 7, 2018 Category: Epidemiology Authors: Robinson E, Gaillard-Campbell D, Gross TP Tags: Adv Orthop Source Type: research

Clinical practice, deliberate practice, and "big data".
Clinical practice, deliberate practice, and "big data". Adv Health Sci Educ Theory Pract. 2018 Dec;23(5):863-866 Authors: Norman G Abstract PMID: 30421094 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - November 14, 2018 Category: Epidemiology Authors: Norman G Tags: Adv Health Sci Educ Theory Pract Source Type: research

Alterations in platelet secretion differentially affect thrombosis and hemostasis.
Abstract We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2 and VAMP3. VAMP2Δ3Δ8-/- platelets also had reduced VAMP7. Loss of VAMP2 and VAMP3 (VAMP2Δ3Δ) had a minimal impact on secretion when VAMP7 and VAMP8 were present. Integrin αIIbβ3 activation and aggregation were not affected, although spreading was reduced in VAMP2Δ3&Delt...
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Joshi S, Banerjee M, Zhang J, Kesaraju A, Pokrovskaya ID, Storrie B, Whiteheart SW Tags: Blood Adv Source Type: research

Using Health System Data for Improvement Science: Getting Started.
PMID: 30185502 [PubMed - in process] (Source: Adv Data)
Source: Adv Data - September 8, 2018 Category: Epidemiology Authors: Zhao Y, Granger BB Tags: AACN Adv Crit Care Source Type: research