A systematic assessment of the impact of rare canonical splice site variants on splicing using functional and in silico methods
CONCLUSION: Approximately 1 in 4 rare CSSVs may not cause LoF based on analysis of RNA-seq data. Predictions from in silico methods were often discordant with findings from RNA-seq. More caution may be warranted in applying PVS1-level evidence to CSSVs in the absence of functional data.PMID:38659227 | DOI:10.1016/j.xhgg.2024.100299 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Rachel Y Oh Ali Almail David Cheerie George Guirguis Huayun Hou Kyoko E Yuki Bushra Haque Bhooma Thiruvahindrapuram Christian R Marshall Roberto Mendoza-Londono Adam Shlien Lianna G Kyriakopoulou Susan Walker James J Dowling Michael D Wilson Gregory Costa Source Type: research
Comparison of the Effects of E-learning Blended with Collaborative Learning and Lecture-Based Teaching Approaches on Academic Self-Efficacy among Undergraduate Nursing Students: A Quasi-Experimental Study
CONCLUSION: Blending the EL and CL approaches significantly promoted CASE among the undergraduate nursing students in this study by providing sufficient collaboration, essential educational equipment, and better technical support.PMID:38660430 | PMC:PMC11036318 | DOI:10.30476/JAMP.2024.99100.1828 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Masumeh Hemmati Malsakpak Sima Pourteimour Source Type: research
The Effect of Teaching Professionalism by Using Real Lifetime Scenarios in Undergraduate Medical Students: An Educational Trial
CONCLUSION: This research showed that the teaching of professionalism using real lifetime scenarios led to statistically significant improvement of professionalism in the form of P-MEX mean score among final MBBS students.PMID:38660431 | PMC:PMC11036315 | DOI:10.30476/JAMP.2024.100869.1904 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Shazia Rasul Saima Chaudhry Aflak Rasheed Source Type: research
The Effect of Direct Observation of Procedural Skills on Learning and Satisfaction of Students in Community Dentistry Course
CONCLUSION: The DOPS method had more impact on Fluoride therapy, pit and fissure sealant therapy, and health education's learning process in dentistry students than the conventional evaluation. The professors and students' satisfaction level was high regarding DOPS. The advantages of the DOPS method are student-centeredness, objectivity, and appropriate feedback.PMID:38660432 | PMC:PMC11036320 | DOI:10.30476/JAMP.2023.100431.1890 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Fatemeh Dabaghi Tabriz Ayla Bahramian Saeede Asdagh Farnaz Ghadimi Katayoun Katebi Source Type: research
Evaluating The Quality of Medicine Curriculum Based on the Kano Model
CONCLUSION: Therefore, it can be concluded that the curriculum of medicine in implementation (perception) stage does not accord with the expectations of the students, and it is necessary to pay attention to the needs and expectations of the students.PMID:38660437 | PMC:PMC11036322 | DOI:10.30476/JAMP.2024.100826.1900 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Davood Tahmasbzadeh Sheikhlar Mehrdad Aziminejadian Toran Mirzaei Sangin Source Type: research
Parents' Trigger Tool for Children with Medical Complexity - PAT-CMC: Development of a recognition tool for clinical deterioration at home
CONCLUSION: Priority indicators of clinical deterioration of CMC were identified and integrated into a validated trigger tool designed for parents or other lay caregivers at home, to recognize signs of acute severe illness and initiate healthcare interventions.IMPACT: The PAT-CMC was developed to guide families in recognizing signs of deterioration in CMC and has potential for initiating an early escalation of care. This tool may also be useful to support education provided by healthcare providers to families before hospital discharge.PATIENT OR PUBLIC CONTRIBUTION: Parents of CMC were directly involved in the selection of...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Catia Genna Kiara Ros Thekkan Caterina Geremia Michela Di Furia Corrado Cecchetti Emilia Rufini Michele Salata Daniela Perrotta Immacolata Dall'Oglio Emanuela Tiozzo Massimiliano Raponi Orsola Gawronski Source Type: research
Factors affecting environmental sustainability attitudes among nurses - Focusing on climate change cognition and behaviours: A cross-sectional study
CONCLUSIONS: Nurses' motivation, climate change concern and pro-environmental workplace practices should all be considered to improve their attitudes towards environmental sustainability.IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: To enhance nurses' environmental sustainability attitudes and behaviours, nurse educators must educate them to increase their motivation for climate action.IMPACT: Nurses are increasingly expected to contribute to environmental sustainability. Hence, awareness of climate change and environmental sustainability among nurses must be improved, and nursing engagement and action encouraged. N...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Sophia J Chung Haeyoung Lee Sun Joo Jang Source Type: research
The Relationship Between Dental Provider Density and Receipt of Dental Care Among Medicaid-enrolled Adults
CONCLUSION: Dentist participation in Medicaid program may be a modifiable barrier to Medicaid-enrolled adults' receipt of dental care.PMID:38661867 (Source: Adv Data)
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Heather L Taylor Nir Menachemi Ann Holmes Bisakha Sen Titus Schleyer Justin Blackburn Source Type: research
Maternal red blood cell alloimmunization prevalence in the United States
This study describes prevalence and trends in alloimmunization in pregnancy in the U.S. RBC antibodies (abs) were identified in a large, nationwide, commercial laboratory database from 2010-2021. The cohort comprised pregnancies for which the year of lab collection and patient's state of residence were available. Data were normalized based on U.S. Centers for Disease Control and Prevention estimates of live births and weighted by year and U.S. Census Division. Cochrane-Armitage tests assessed temporal trends of alloimmunization. Of 9,876,196 pregnancies, 1.5% (147,262) screened positive for RBC abs, corresponding to an est...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Ronan P Sugrue Kenneth J Moise Jerome J Federspiel Elizabeth Abels Judy Z Louie Zhen Chen Lance A Bare Damian P Alagia Harvey W Kaufman Source Type: research
In vitro data suggest a role for PMS2 Kozak sequence mutations in Lynch Syndrome risk
HGG Adv. 2024 Apr 22:100298. doi: 10.1016/j.xhgg.2024.100298. Online ahead of print.ABSTRACTLynch Syndrome (LS) is the most common hereditary cancer syndrome. Heterozygous loss-of-function variants in PMS2 are linked to LS. While these variants are not directly cancer causing, reduced PMS2 function results in the accumulation of somatic variants and increased cancer risk over time due to DNA mismatch repair dysfunction. It is reasonable that other types of genetic variation that impact the expression of PMS2 may also contribute to cancer risk. The Kozak sequence is a highly conserved translation initiation motif among high...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Evanjalina J Matoy Jocelyn N Plowman Cynthia J Watson Michael A Belshan Elizabeth E Blue Chad D Huff Holly A F Stessman Source Type: research
Self-Powered Biomimetic Pressure Sensor Based on Mn-Ag Electrochemical Reaction for Monitoring Rehabilitation Training of Athletes
This study proposes a dual-response potentiometric pressure sensor that responds to both dynamic and static stimuli. The proposed sensor utilizes interdigital electrodes with MnO2/carbon/polyvinyl alcohol (PVA) as the cathode and conductive silver paste as the anode. The electrolyte layer incorporates a mixed hydrogel of PVA and phosphoric acid. The optimized interdigital electrodes and sandpaper-like microstructured surface of the hydrogel electrolyte contribute to enhanced performance by facilitating an increased contact area between the electrolyte and electrodes. The sensor features an open-circuit voltage of 0.927 V, ...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Ziyan Yang Qingzhou Wang Huixin Yu Qing Xu Yuanyue Li Minghui Cao Rajendra Dhakal Yang Li Zhao Yao Source Type: research
Double Nitrogenation Layer Formed Using Nitric Oxide for Enhancing Li < sup > + < /sup > Storage Performance, Cycling Stability, and Safety of Si Electrodes
Adv Sci (Weinh). 2024 Apr 24:e2310062. doi: 10.1002/advs.202310062. Online ahead of print.ABSTRACTTo enhance Li storage properties, nitrogenation methods are developed for Si anodes. First, melamine, urea, and nitric oxide (NO) precursors are used to nitrogenize carbon-coated Si particles. The properties of the obtained particles are compared. It is found that the NO process can maximize the graphitic nitrogen (N) content and electronic conductivity of a sample. In addition, optimized N functional groups and O─C species on the electrode surface increase electrolyte wettability. However, with a carbon barrier layer, NO ha...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Rahmandhika Firdauzha Hary Hernandha Bharath Umesh Jagabandhu Patra Chung-Jen Tseng Chien-Te Hsieh Ju Li Jeng-Kuei Chang Source Type: research
Sampling Real-Time Atomic Dynamics in Metal Nanoparticles by Combining Experiments, Simulations, and Machine Learning
Adv Sci (Weinh). 2024 Apr 24:e2307261. doi: 10.1002/advs.202307261. Online ahead of print.ABSTRACTEven at low temperatures, metal nanoparticles (NPs) possess atomic dynamics that are key for their properties but challenging to elucidate. Recent experimental advances allow obtaining atomic-resolution snapshots of the NPs in realistic regimes, but data acquisition limitations hinder the experimental reconstruction of the atomic dynamics present within them. Molecular simulations have the advantage that these allow directly tracking the motion of atoms over time. However, these typically start from ideal/perfect NP structures...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Matteo Cioni Massimo Delle Piane Daniela Polino Daniele Rapetti Martina Crippa Ece Arslan Irmak Sandra Van Aert Sara Bals Giovanni M Pavan Source Type: research
The sequential antifracturative treatment: a meta-analysis of randomized clinical trials
CONCLUSION: The Task Force formulated recommendations on sequential therapy, which is the first treatment with anabolic drugs or 'bone builders' in patients with very high or imminent risk of fracture.PMID:38654732 | PMC:PMC11036926 | DOI:10.1177/1759720X241234584 (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Angelo Fassio Davide Gatti Annalisa Biffi Raffaella Ronco Gloria Porcu Giovanni Adami Rosaria Alvaro Riccardo Bogini Achille P Caputi Luisella Cianferotti Bruno Frediani Stefano Gonnelli Giovanni Iolascon Andrea Lenzi Salvatore Leone Raffaella Michieli Si Source Type: research
The analysis of factors affecting medication adherence in patients with myasthenia gravis: a cross-sectional study
CONCLUSION: Our study shows that taking medication irregularly and concerns of taking medicine are the risk factors for medication adherence. Meanwhile, the necessity of talking medicine and self-efficacy for taking medications under difficult circumstances are the protective factors for medication adherence. Our findings can help medical staff to enhance patients' medication adherence by informing patients necessary medical knowledge, emphasizing the necessity for medication, relieving patients' concerns regarding medication, and improving the self-efficacy for taking medications under difficult circumstances.PMID:3865474...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Yining Su Xinxian Wang Yuemeng Xing Zhenni Wang Hailing Bu Xiaoyan Cui Yunying Yang Bingxing Cai Source Type: research
