Preoperative growth dynamics of untreated glioblastoma: Description of an exponential growth type, correlating factors, and association with postoperative survival
CONCLUSIONS: Especially small lesions suggestive of glioblastoma showed exponential tumor growth with variable growth rates and a median VDT of 31 days. SGR was significantly associated with OS in patients with tumor resection in our sample.PMID:38680987 | PMC:PMC11046984 | DOI:10.1093/noajnl/vdae053 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Daniel Feucht Patrick Haas Marco Skardelly Felix Behling David Rieger Paula Bombach Frank Paulsen Elgin Hoffmann Till-Karsten Hauser Benjamin Bender Mirjam Renovanz Maximilian Niyazi Ghazaleh Tabatabai Marcos Tatagiba Constantin Roder Source Type: research
Contemporary trends in the incidence and timing of spinal metastases: A population-based study
CONCLUSIONS: The incidence of spinal metastases has increased in recent years, particularly among older patients. The incidence and timing vary substantially among different primary cancer types. These findings contribute to the understanding of disease trends and emphasize a growing population of patients who require subspecialty care.PMID:38680988 | PMC:PMC11046986 | DOI:10.1093/noajnl/vdae051 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Husain Shakil Armaan K Malhotra Jetan H Badhiwala Vishwathsen Karthikeyan Ahmad Essa Yingshi He Michael G Fehlings Arjun Sahgal Nicolas Dea Alex Kiss Christopher D Witiw Donald A Redelmeier Jefferson R Wilson Source Type: research
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
CONCLUSIONS: Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.PMID:38680989 | PMC:PMC11055465 | DOI:10.1093/noajnl/vdae056 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Emily Y Kim Amy L Vavere Scott E Snyder Jason Chiang Yimei Li Tushar Patni Ibrahim Qaddoumi Thomas E Merchant Giles W Robinson Joseph L Holtrop Barry L Shulkin Asim K Bag Source Type: research
A phase I dose-escalation study of pulsatile afatinib in patients with recurrent or progressive brain cancer
CONCLUSIONS: Afatinib taken orally was safe and well-tolerated up to 280 mg every 7 days in brain cancer patients.PMID:38680990 | PMC:PMC11046985 | DOI:10.1093/noajnl/vdae049 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Tiffany M Juarez Jaya M Gill Annie Heng Jose A Carrillo Naveed Wagle Natsuko Nomura Minhdan Nguyen Judy Truong Lucia Dobrawa Walavan Sivakumar Garni Barkhoudarian Daniel F Kelly Santosh Kesari Source Type: research
Radiogenomic biomarkers for immunotherapy in glioblastoma: A systematic review of magnetic resonance imaging studies
CONCLUSIONS: Radiogenomic immune biomarkers have the potential to provide early treatment options to patients with glioblastoma. Targeted immunotherapy, stratified by these biomarkers, has the potential to allow individualized neo-adjuvant precision treatment options in clinical trials. However, there are no prospective studies validating these biomarkers, and interpretation is limited due to study bias with little evidence of generalizability.PMID:38680991 | PMC:PMC11046988 | DOI:10.1093/noajnl/vdae055 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Prajwal Ghimire Ben Kinnersley Golestan Karami Prabhu Arumugam Richard Houlston Keyoumars Ashkan Marc Modat Thomas C Booth Source Type: research
Unique genomic alterations in the circulating tumor DNA of patients with solid tumors brain metastases
CONCLUSIONS: This study illustrates the feasibility of detecting alterations from ctDNA among patients with BrMs. A higher frequency of actionable mutations was observed in ctDNA in patients with BrMs. Additional studies comparing ctDNA and alterations in BrMs tissue are needed to determine if ctDNA can be considered a surrogate to support treatment decisions.PMID:38680992 | PMC:PMC11046982 | DOI:10.1093/noajnl/vdae052 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Laura Alder Gloria Broadwater Michelle Green Amanda E D Van Swearingen Eric S Lipp Jeffrey Melson Clarke Carey K Anders Sarah Sammons Source Type: research
FlexStat: combinatory differentially expressed protein extraction
Bioinform Adv. 2024 Apr 11;4(1):vbae056. doi: 10.1093/bioadv/vbae056. eCollection 2024.ABSTRACTMOTIVATION: Mass spectrometry-based system proteomics allows identification of dysregulated protein hubs and associated disease-related features. Obtaining differentially expressed proteins (DEPs) is the most important step of downstream bioinformatics analysis. However, the extraction of statistically significant DEPs from datasets with multiple experimental conditions or disease types through currently available tools remains a laborious task. More often such an analysis requires considerable bioinformatics expertise, making it...
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Senuri De Silva Asfa Alli-Shaik Jayantha Gunaratne Source Type: research
Navigating the outcome maze: a scoping review of outcomes and instruments in clinical trials in genetic neurodevelopmental disorders and intellectual disability
CONCLUSION: This scoping review of current practice reveals a myriad of outcomes and outcome measurement instruments for clinical trials in GNDs and ID. This complicates generalization, evidence synthesis, and evaluation. It underlines the need for consensus on suitability, validity, and relevancy of instruments, ultimately resulting in a core outcome set. A series of steps is proposed to move from the myriad of measures to a more unified approach.PMID:38681798 | PMC:PMC11047260 | DOI:10.1177/26330040241245721 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Annelieke R M üller Nadia Y van Silfhout Bibiche den Hollander Dick H C Kampman Lianne Bakkum Marion M M G Brands Lotte Haverman Caroline B Terwee Carlo Schuengel Joost Daams David Hessl Frits A Wijburg Erik Boot Agnies M van Eeghen Source Type: research
Developing a pathway to clinical trials for < em > CACNA1A < /em > -related epilepsies: A patient organization perspective
Ther Adv Rare Dis. 2024 Apr 25;5:26330040241245725. doi: 10.1177/26330040241245725. eCollection 2024 Jan-Dec.ABSTRACTCACNA1A-related disorders are rare neurodevelopmental disorders linked to variants in the CACNA1A gene. This gene encodes the α1 subunit of the P/Q-type calcium channel Cav2.1, which is globally expressed in the brain and crucial for fast synaptic neurotransmission. The broad spectrum of CACNA1A-related neurological disorders includes developmental and epileptic encephalopathies, familial hemiplegic migraine type 1, episodic ataxia type 2, spinocerebellar ataxia type 6, together with unclassified presentati...
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Pangkong M Fox Sunitha Malepati Lisa Manaster Elsa Rossignol Jeffrey L Noebels Source Type: research
Construction of a novel ternary synergistic CuFe < sub > 2 < /sub > O < sub > 4 < /sub > -SnO < sub > 2 < /sub > -rGO heterojunction for efficient removal of cyanide from contaminated water
RSC Adv. 2024 Apr 26;14(20):13850-13861. doi: 10.1039/d4ra02217c. eCollection 2024 Apr 25.ABSTRACTMany industrial effluents release cyanide, a well-known hazardous and bio-recalcitrant pollutant, and thus, the treatment of cyanide wastewater is a major challenge. In the current study, a CuFe2O4-SnO2-rGO nanocomposite was synthesized to remove cyanide from an aqueous system. The structural and morphological characterizations of the nanomaterials were investigated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive spectra (EDX) analysis. The re...
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Soumya Mishra Naresh Kumar Sahoo Prasanta Kumar Sahoo Satyanjib Sahoo Lopamudra Nayak Prangya Ranjan Rout Source Type: research
Continuous Positive Airway Pressure-Assisted Breathing With Supine Tangential Left Breast Radiation Therapy When Deep Inspiration Breath-Hold Radiation Therapy Was Ineffective or Unsuitable: Clinical Implications for an Affordable Heart-Sparing Breast Radiation Therapy to Reduce the Health Care Disparities in Low-Resource Settings
CONCLUSIONS: CPAP-RT provides efficient and practical heart and LAD sparing RT using simple supine tangential fields for Breast-RT or wide-tangential fields for Breast + IMN-RT when DIBH-RT was ineffective or unsuitable. With its easy accessibility and low infrastructural requirement, CPAP-RT can provide affordable heart-sparing left breast RT to reduce the health care disparities in low-resource settings.PMID:38681888 | PMC:PMC11043812 | DOI:10.1016/j.adro.2024.101472 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Whoon Jong Kil Wyatt Smith Craig Herndon Warren Shipe Source Type: research
How Does the Number of Brain Metastases Correlate With Normal Brain Exposure in Single-Isocenter Multitarget Multifraction Stereotactic Radiosurgery
CONCLUSIONS: Based on clinical SRT plans, our study provides information on correlations between normal brain exposure and the number and total volume of targets. As SRT becomes more greatly used for patients with increasingly extensive brain metastases, more clinical data on outcomes and toxicities is necessary to better define the normal brain dose constraints for high-exposure cases and to optimize the SRT management for those patients.PMID:38681891 | PMC:PMC11047183 | DOI:10.1016/j.adro.2024.101499 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Dandan Zheng Jihyung Yoon Hyunuk Jung Olga Maria Dona Lemus Lang Gou Yuwei Zhou Kenneth Y Usuki Sara Hardy Michael T Milano Source Type: research
Spatial Pattern of Intraprostatic Recurrence after Definitive External-Beam Radiation Therapy for Prostate Cancer: Implications for Focal Boost to Intraprostatic Dominant Lesion
CONCLUSIONS: Local intraprostatic recurrence after definitive EBRT often occurs at the same site or at a partially overlapping site adjacent to the primary intraprostatic dominant lesion. Our results support the merit of focal dose-escalation for intraprostatic dominant lesions in definitive EBRT.PMID:38681892 | PMC:PMC11043806 | DOI:10.1016/j.adro.2024.101489 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Rihito Aizawa Tomoaki Otani Takashi Ogata Yusaku Moribata Aki Kido Shusuke Akamatsu Takayuki Goto Kimihiko Masui Takayuki Sumiyoshi Yuki Kita Takashi Kobayashi Yuji Nakamoto Takashi Mizowaki Source Type: research
Dosimetric Comparison of CPAP and DIBH for Left-sided Breast Cancer Radiation Therapy
CONCLUSIONS: The comparison between CPAP and DIBH shows their similarity in both geometric and dosimetric aspects, providing strong evidence for CPAP's effectiveness and feasibility in RT. This suggests its potential as an alternative to DIBH for patients with left-sided breast cancer.PMID:38681894 | PMC:PMC11043855 | DOI:10.1016/j.adro.2024.101478 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Min Seo Choi Ryeong Hwang Park Joongyo Lee Yeona Cho Jee Suk Chang Jihun Kim Jin Sung Kim Source Type: research
Sarcopenia as a Predictor of Feeding Tube Placement in Individuals with Oropharyngeal Cancer
CONCLUSIONS: SMM measured at T4 may represent a novel and practical biomarker for sarcopenia detection that is associated with the need for FT placement. These findings suggest that the detection of baseline sarcopenia could guide decision-making related to the need for nutritional support in OPSCC patients undergoing RT/CRT.PMID:38681896 | PMC:PMC11043844 | DOI:10.1016/j.adro.2024.101484 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Nedeljko Jovanovic David A Palma Andrew Warner Sylvia Mitchell Philip C Doyle Julie A Theurer Source Type: research
