Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination
Sci Adv. 2024 Apr 12;10(15):eadm7600. doi: 10.1126/sciadv.adm7600. Epub 2024 Apr 12.ABSTRACTMyelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mou...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Paula Ayuso-Garc ía Alejandro S ánchez-Rueda Sergio Velasco-Avil és Miguel Tamayo-Caro Aroa Ferrer-Pin ós Cecilia Huarte-Sebastian Vanesa Alvarez Cristina Riobello Selene Jim énez-Vega Izaskun Buendia Jorge Ca ñas-Martin H éctor Fernández-Susavila Source Type: research
Merging total synthesis and NMR technology for deciphering the realistic structure of natural 2,6-dideoxyglycosides
Sci Adv. 2024 Apr 12;10(15):eadn1305. doi: 10.1126/sciadv.adn1305. Epub 2024 Apr 12.ABSTRACTThe structural identification and efficient synthesis of bioactive 2,6-dideoxyglycosides are daunting challenges. Here, we report the total synthesis and structural revision of a series of 2,6-dideoxyglycosides from folk medicinal plants Ecdysanthera rosea and Chonemorpha megacalyx, which feature pregnane steroidal aglycones bearing an 18,20-lactone and glycans consisting of 2,6-dideoxy-3-O-methyl-β-pyranose residues, including ecdysosides A, B, and F and ecdysantheroside A. All the eight possible 2,6-dideoxy-3-O-methyl-β-pyranosi...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Zhaolun Zhang Renjie Wu Shen Cao Jiaji Li Guangen Huang Haoyu Wang Tao Yang Wei Tang Peng Xu Biao Yu Source Type: research
Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection
Sci Adv. 2024 Apr 12;10(15):eadm8841. doi: 10.1126/sciadv.adm8841. Epub 2024 Apr 12.ABSTRACTAllograft rejection is common following clinical organ transplantation, but defining specific immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose escalation, corticosteroids, and/or lymphocyte depleting antibodies have remained the primary options for treatment of clinical rejection episodes. Here, we developed a highly multiplexed imaging mass cytometry panel to study the immune response in archival biopsies from 79 liver transplant (LT) recipients with either no rejection (NR), acute T cell-mediated ...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Arianna Barbetta Brittany Rocque Sarah Bangerth Kelly Street Carly Weaver Shefali Chopra Janet Kim Linda Sher Brice Gaudilliere Omid Akbari Rohit Kohli Juliet Emamaullee Source Type: research
Clonal Hematopoiesis and Inflammation in the VasculaturE (CHIVE): a prospective, longitudinal cohort and biorepository
Blood Adv. 2024 Apr 12:bloodadvances.2023011510. doi: 10.1182/bloodadvances.2023011510. Online ahead of print.ABSTRACTClonal hematopoiesis (CH) is an age-associated phenomenon leading to increased risk of both hematologic malignancy and non-malignant organ dysfunction. Increasingly available genetic testing has made incidental discovery of CH clinically common, yet evidence-based guidelines and effective management strategies to prevent adverse CH health outcomes are lacking. To address this gap, the prospective CHIVE registry and biorepository was created to identify and monitor individuals at risk, support multidisciplin...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Morgan L Shannon Jonathan Brett Heimlich Sydney Olson Ariana Debevec Zachary Copeland Ashwin Kishtagari Caitlyn Vlasschaert Christina A Snider Alexander J Silver Donovan Brown Travis P Spaulding Manasa Ram Bhatta Kelly Pugh Shannon S Stockton Jessica Ullo Source Type: research
2022 Review of the 2019 American Society of Hematology Guidelines on Immune Thrombocytopenia
We describe here results of a review of the 2019 guidelines by a working group of experts requested by ASH to inform decision-making about the need for and timing of a guideline revision. An updated Medline and Embase search applied the same search terms as in the 2019 ASH guidelines, limited to systematic reviews and clinical trials, from May 2017 to July 2022. There were 193 studies identified, 102 underwent abstract review and 54 full review. Each study was assessed based on relevance to the previous recommendation with regards to the population, prioritized outcomes, new outcomes, and study design. Reviewers assessed i...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Cindy E Neunert Donald M Arnold Rachael F Grace Thomas K ühne Keith R McCrae Deirdra R Terrell Source Type: research
Formation of Anisotropic Conducting Interlayer for High-Resolution Epidermal Electromyography Using Mixed-Conducting Particulate Composite
Adv Sci (Weinh). 2024 Apr 10:e2308014. doi: 10.1002/advs.202308014. Online ahead of print.ABSTRACTEpidermal electrophysiology is a non-invasive method used in research and clinical practices to study the electrical activity of the brain, heart, nerves, and muscles. However, electrode/tissue interlayer materials such as ionically conducting pastes can negatively affect recordings by introducing lateral electrode-to-electrode ionic crosstalk and reducing spatial resolution. To overcome this issue, biocompatible, anisotropic-conducting interlayer composites (ACI) that establish an electrically anisotropic interface with the s...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Zifang Zhao Han Yu Duncan J Wisniewski Claudia Cea Liang Ma Eric M Trautmann Mark M Churchland Jennifer N Gelinas Dion Khodagholy Source Type: research
Exploring Perceptions and Practices of Interprofessional Shared Decision-Making Education in Palliative Care Settings
CONCLUSION: The findings show high levels of perception with low levels of practice of IP-SDM in palliative care. Other factors that could be associated with the topic should be addressed in further studies.PMID:38600963 | PMC:PMC11005846 | DOI:10.2147/AMEP.S450166 (Source: Adv Data)
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Lama Sultan Nynke de Jong Basim Alsaywid Muhammad Anwar Khan Jascha de Nooijer Source Type: research
< em > Amaranthus hybridus < /em > waste solid biofuel: comparative and machine learning studies
This study aims at developing bio-briquettes from Amaranthus hybridus waste, with cassava starch as a binder; both are agricultural wastes. Before and following delignification, alkali-treated Amaranthus hybridus (TAHB) and untreated (UAHB) briquettes were evaluated in terms of combustion and physicochemical parameters. FTIR and SEM were utilized to monitor the morphological transformation and bond restructuring of TAHB and UAHB samples. EDXRF was used to assess the Potential Toxic Elements (PTEs) composition and environmental friendliness of both TAHB and UAHB. Furthermore, Adaptive Neuro-Fuzzy Inference System (ANFIS) an...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Abayomi Bamisaye Ayodeji Rapheal Ige Kayode Adesina Adegoke Idowu Abimbola Adegoke Muyideen Olaitan Bamidele Yakubu Adekunle Alli Oluwatobi Adeleke Mopelola Abidemi Idowu Source Type: research
Never-Ending Learning for Explainable Brain Computing
Adv Sci (Weinh). 2024 Apr 11:e2307647. doi: 10.1002/advs.202307647. Online ahead of print.ABSTRACTExploring the nature of human intelligence and behavior is a longstanding pursuit in cognitive neuroscience, driven by the accumulation of knowledge, information, and data across various studies. However, achieving a unified and transparent interpretation of findings presents formidable challenges. In response, an explainable brain computing framework is proposed that employs the never-ending learning paradigm, integrating evidence combination and fusion computing within a Knowledge-Information-Data (KID) architecture. The fra...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Hongzhi Kuai Jianhui Chen Xiaohui Tao Lingyun Cai Kazuyuki Imamura Hiroki Matsumoto Peipeng Liang Ning Zhong Source Type: research
CodLncScape Provides a Self-Enriching Framework for the Systematic Collection and Exploration of Coding LncRNAs
This study introduces codLncScape, a framework for coding lncRNA exploration consisting of codLncDB, codLncFlow, codLncWeb, and codLncNLP. Specifically, it contains a manually compiled knowledge base, codLncDB, encompassing 353 coding lncRNA entries validated by experiments. Building upon codLncDB, codLncFlow investigates the expression characteristics of these lncRNAs and their diagnostic potential in the pan-cancer context, alongside their association with spermatogenesis. Furthermore, codLncWeb emerges as a platform for storing, browsing, and accessing knowledge concerning coding lncRNAs within various programming envir...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Tianyuan Liu Huiyuan Qiao Zixu Wang Xinyan Yang Xianrun Pan Yu Yang Xiucai Ye Tetsuya Sakurai Hao Lin Yang Zhang Source Type: research
Organ Involvement in Adults with BPDCN is Associated with Sun Exposure History, TET2 and RAS Mutations, and Survival
Blood Adv. 2024 Apr 11:bloodadvances.2024012797. doi: 10.1182/bloodadvances.2024012797. Online ahead of print.ABSTRACTBlastic plasmacytoid dendritic cell neoplasm (BPDCN) can involve skin, bone marrow (BM), central nervous system (CNS), and non-CNS extramedullary sites. Preclinical models demonstrated clonal advantage of TET2-mutated plasmacytoid dendritic cells exposed to UV radiation. However, whether sun exposure, disease characteristics, and patient survival are clinically related is unclear. We classified 66 BPDCN patients based on organ involvement at diagnosis as skin only (n=19), systemic plus skin (n=33), or syste...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Shai Shimony Julia H Keating Christopher J Fay Marlise R Luskin Donna S Neuberg Nicole R LeBoeuf Andrew A Lane Source Type: research
Becoming a parent: Trajectories of family division of labor in Germany and the United States
Adv Life Course Res. 2024 Mar 31;60:100611. doi: 10.1016/j.alcr.2024.100611. Online ahead of print.ABSTRACTThe transition to parenthood represents a turning point shaping couples' arrangements for paid work and housework. Previous studies often examined these changes in isolation, rather than as interrelated trajectories reflecting diverse models of family division of labor. Drawing on data from different-sex couples from the 1984-2019 Panel Study of Income Dynamics and the 1984-2020 German Socio-Economic Panel, this study uses multichannel sequence analysis to identify four and three patterned constellations of family div...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Wen Fan Source Type: research
The experiences among bereaved family members after a left ventricular assist device (LVAD) deactivation
CONCLUSION: Bereaved family members of patients undergoing LVAD deactivation have unique lived experiences and concerns. This study highlights the importance of effective communication not only near end-of-life but throughout the LVAD experience. While the positive relationships with staff and the absence of physical suffering were strengths identified by bereaved caregivers, there is an opportunity for improvement, particularly during the decision-making and post-death periods.PMID:38604055 | DOI:10.1016/j.hrtlng.2024.04.004 (Source: Adv Data)
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Anne Kelemen Hunter Groninger Edilma L Yearwood Casey French Cindy Bither Anirudh Rao Kelley M Anderson Source Type: research
The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo
Hypertens Res. 2024 Apr 11. doi: 10.1038/s41440-024-01678-8. Online ahead of print.ABSTRACTPreeclampsia is classified as new-onset hypertension coupled with gross endothelial dysfunction. Placental (pro)renin receptor ((P)RR) and plasma soluble (P)RR (s(P)RR) are elevated in patients with preeclampsia. Thus, we aimed to interrogate the role (P)RR may play in the pathogenesis of preeclampsia. Human uterine microvascular endothelial cells (HUtMECs, n = 4) were cultured with either; vehicle (PBS), 25-100 nM recombinant s(P)RR, or 10 ng/ml TNF-a (positive control) for 24 h. Conditioned media and cells were assessed for endothe...
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Lachlan G Schofield Sarah J Delforce Jennifer C Pryor Saije K Endacott Eugenie R Lumbers Sarah A Marshall Kirsty G Pringle Source Type: research
Ultrasonographic and power doppler parameters of nails fail to differentiate between onychodystrophy in patients with psoriasis vulgaris or psoriatic arthritis
CONCLUSION: Greater nail bed thickness indicates early psoriatic nail disease, as confirmed in our study correlating NAPSI with nail bed thickness. Ultrasonography is a low-cost exam, promising in the evaluation, showing that the ultrasound grayscale is consistent with those who have dystrophic nails, but it can't distinguish psoriasis from psoriatic arthritis, even in those with nail dystrophy.PMID:38605415 | DOI:10.1186/s42358-024-00367-x (Source: Adv Data)
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Anber Ancel Tanaka Betina Werner Annelise Correa Bueno Bragatto Thelma Larocca Skare B árbara Stadler Source Type: research
