Immunogenicity profile of rurioctocog alfa pegol in previously treated patients with severe congenital hemophilia A
Blood Adv. 2024 Apr 2:bloodadvances.2023011780. doi: 10.1182/bloodadvances.2023011780. Online ahead of print.ABSTRACTRurioctocog alfa pegol is an extended half-life full-length recombinant factor VIII (FVIII) bound to 20 kDa polyethylene glycol (PEG) that has been shown to be well tolerated and efficacious in the treatment and prevention of bleeding events in previously treated patients with severe hemophilia A. Here, we present a comprehensive analysis of immunogenicity data collected during 6 clinical studies of rurioctocog alfa pegol including a total of 360 unique previously treated patients with severe hemophilia A. T...
Source: Adv Data - April 2, 2024 Category: Epidemiology Authors: Frank M Horling Birgit M Reipert Peter Allacher Werner Engl Luying Pan Srilatha D Tangada Source Type: research
Immune status and selection of patients for immunotherapy in myeloma: a Proposal
Blood Adv. 2024 Apr 2:bloodadvances.2023011242. doi: 10.1182/bloodadvances.2023011242. Online ahead of print.ABSTRACTNewer immune-based approaches based on recruitment and redirection of endogenous and/or synthetic immunity such as chimeric antigen-receptor-T (CAR-T) cells or bispecific antibodies are transforming the clinical management of multiple myeloma (MM). Contributions of the immune system to the anti-tumor effects of myeloma therapies are also increasingly appreciated. Clinical malignancy in MM originates in the setting of systemic immune alterations that begin early in myelomagenesis and regional changes in immun...
Source: Adv Data - April 2, 2024 Category: Epidemiology Authors: Madhav V Dhodapkar Source Type: research
Nurses' and midwives' experiences of managing parental postnatal depression: A scoping review
CONCLUSION: The review highlights significant gaps in the nurses' and midwives' care of PPND. Educational programmes are necessary to increase nurse and midwife knowledge of PPND and strategies for its management, including facilitating collaboration across the healthcare system and eliminating organizational and systemic-related barriers. Additional focused research is needed on nurses' and midwives' knowledge, perception of and experience with PPND beyond mothers, such as with fathers, sexually and gender-minoritized parents and surrogate mothers. Finally, additional research is needed in middle- and lower-income countri...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Paul Shidende Randi Bates Rebecca Lee Carolyn Smith Source Type: research
Home-based management on hospital re-admission rates in COPD patients: A systematic review
CONCLUSION: Given the burden of COPD on healthcare systems, and crucially on individuals, this review identified a reduction in hospital re-admission rate, a clinically important outcome.IMPACT: This study focused on the impact on hospital re-admission rates among the COPD patient cohort when home-based management was involved. A statistically significant reduction in rates of re-admission to the hospital was identified. This is positive for the patient, in terms of hospital avoidance, and reduces the burden on hospital systems. Further research is needed to determine the impact on cost-effectiveness and to quantify the mo...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Rita Corcoran Zena Moore Pinar Avsar Bridget Murray Source Type: research
The impact of digital technology use on nurses' professional identity and relations of power: a literature review
CONCLUSION: Our review presents insights into the relation between technology and nurses' professional identity and prevalent power relations. For future studies, dedicated and critical investigations of digital technologies' impact on the formation of professional identity in nursing are required.IMPLICATIONS FOR THE PROFESSION: Nurses' professional identity may be altered by digital technologies used in clinical care. Nurses, who are aware of the potential effects of digitized work environments, can reflect on the relationship of technology and the nursing profession.IMPACT: The use of digital technology might lead to a ...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Michael Knop Marius Mueller Stephanie Kaiser Christian Rester Source Type: research
An innovative low-cost breast pump-hire program to enhance breastfeeding rates in a neonatal intensive care unit
CONCLUSION: The findings suggested that the low-cost breast pump hire program supported equitable care, increasing women's ability to provide expressed breastmilk for their infants.IMPACT: Providing access to low-cost hospital-grade breast pumps to mothers of vulnerable infants is likely to prevent poor infant clinical outcomes and improve women's care satisfaction.PUBLIC OR PATIENT CONTRIBUTION: Nil.PMID:38558479 | DOI:10.1111/jan.16180 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Linda Sweet Jessica Hughes Asiyath Rasheed Vidanka Vasilevski Source Type: research
Mechanical Control of Quantum Transport in Graphene
This article reports measurements of quantum transport in strained graphene transistors which agree quantitatively with models based on mechanically-induced gauge potentials. A scalar potential is mechanically induced in-situ to modify graphene's work function by up to 25 meV. Mechanically generated vector potentials suppress the ballistic conductance of graphene by up to 30 % and control its quantum interferences. The data were measured with a custom experimental platform able to precisely tune both the mechanics and electrostatics of suspended graphene transistors at low-temperature over a broad range of strain (up to 2....
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Andrew C McRae Guoqing Wei Linxiang Huang Serap Yigen Vahid Tayari Alexandre R Champagne Source Type: research
A new variant of the inherent strain method for the prediction of distortion in powder bed fusion additive manufacturing processes
Int J Adv Manuf Technol. 2024;131(9-10):4575-4594. doi: 10.1007/s00170-024-13255-x. Epub 2024 Feb 26.ABSTRACTA new variant of the inherent strain (IS) method is proposed to predict component distortion in powder bed fusion additive manufacturing (AM) that addresses some of the shortcomings of the previous work by accounting for both the compressive plastic strain formed adjacent to the melt pool and the thermal strain associated with the changing macroscale thermal field in the component during fabrication. A 3D thermomechanical finite element (FE) model using the new approach is presented and applied to predict the distor...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Pegah Pourabdollah Farzaneh Farhang Mehr Steve Cockcroft Daan Maijer Source Type: research
Time interval between surgery and adjuvant chemotherapy in patients with gastric cancer after gastrectomy: a population-based cohort study using a nationwide claim database
CONCLUSION: Adjuvant chemotherapy after gastrectomy in patients with gastric cancer should be initiated within 5 weeks of surgery. A delay of more than 5 weeks may have a detrimental effect on the subsequent disease course.PMID:38559613 | PMC:PMC10981231 | DOI:10.1177/17588359241241972 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Chi Hoon Maeng Hoseob Kim Mina Kim Source Type: research
Treatment switches of disease-modifying therapies in people with multiple sclerosis: long-term experience from the German MS Registry
CONCLUSION: The initial use of MME DMTs was among the strongest predictors of DMT discontinuation in a large German retrospective MS cohort, arguing for the need for prospective treatment strategy trials, not only but also on the initial broad use of HE DMTs in PwMS.PMID:38560408 | PMC:PMC10981260 | DOI:10.1177/17562864241239740 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Niklas Frahm David Ellenberger Alexander Stahmann Firas Fneish Daniel L üftenegger Hans C Salmen Ksenija Schirduan Tom P A Schaak Peter Flachenecker Christoph Kleinschnitz Friedemann Paul Dagmar Krefting Uwe K Zettl Melanie Peters Clemens Warnke Source Type: research
Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways
CONCLUSION: This study elucidates key metabolic characteristics in UC, offering insights into molecular mechanisms and biomarker discovery for the disease. Future research could focus on validating these findings and exploring their clinical applications.PMID:38560428 | PMC:PMC10981261 | DOI:10.1177/17562848241239580 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Meiling Liu Siyi Guo Liang Wang Source Type: research
A Single-Institution Prospective Study To Evaluate the Safety and Efficacy of Real- Time Image-Gated Spot-Scanning Proton Therapy (RGPT) for Prostate Cancer
CONCLUSIONS: The RGPT for prostate cancer with 1.5-mm markers and 3- or 4- fields was as safe as conventional proton therapy in early AE, and its efficacy was comparable with previous studies.PMID:38560429 | PMC:PMC10981019 | DOI:10.1016/j.adro.2024.101464 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Kentaro Nishioka Takayuki Hashimoto Takashi Mori Yusuke Uchinami Rumiko Kinoshita Norio Katoh Hiroshi Taguchi Koichi Yasuda Yoichi M Ito Seishin Takao Masaya Tamura Taeko Matsuura Shinichi Shimizu Hiroki Shirato Hidefumi Aoyama Source Type: research
ZygosityPredictor
Bioinform Adv. 2024 Feb 6;4(1):vbae017. doi: 10.1093/bioadv/vbae017. eCollection 2024.ABSTRACTSUMMARY: ZygosityPredictor provides functionality to evaluate how many copies of a gene are affected by mutations in next generation sequencing data. In cancer samples, the tool processes both somatic and germline mutations. In particular, ZygosityPredictor computes the number of affected copies for single nucleotide variants and small insertions and deletions (Indels). In addition, the tool integrates information at gene level via phasing of several variants and subsequent logic to derive how strongly a gene is affected by mutati...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Marco Rheinnecker Martina Fr öhlich Marc R übsam Nagarajan Paramasivam Christoph E Heilig Stefan Fr öhling Richard F Schlenk Barbara Hutter Daniel H übschmann Source Type: research
Data-driven information extraction and enrichment of molecular profiling data for cancer cell lines
Bioinform Adv. 2024 Mar 16;4(1):vbae045. doi: 10.1093/bioadv/vbae045. eCollection 2024.ABSTRACTMOTIVATION: With the proliferation of research means and computational methodologies, published biomedical literature is growing exponentially in numbers and volume. Cancer cell lines are frequently used models in biological and medical research that are currently applied for a wide range of purposes, from studies of cellular mechanisms to drug development, which has led to a wealth of related data and publications. Sifting through large quantities of text to gather relevant information on cell lines of interest is tedious and ex...
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Ellery Smith Rahel Paloots Dimitris Giagkos Michael Baudis Kurt Stockinger Source Type: research
Effectiveness of methotrexate and leflunomide as corticoid-sparing drugs in patients with polymyalgia rheumatica
CONCLUSIONS: This study demonstrated the clinical effectiveness of LEF and even its superiority in achieving remission when compared with MTX as GCSD in PMR patients. Further research is needed to support these findings.PMID:38560643 | PMC:PMC10978571 | DOI:10.1093/rap/rkae033 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Juan Pablo Vinicki Alejandra Cusa Daniela Domingo Jos é Luis Velasco Zamora Sebasti án Magri Alejandro Brigante Maria Marcela Schmid Paola Ávila Natalia Zamora Laura Sorrentino Anabella M Rodriguez Miguel Linarez Cecilia Pisoni Carolina Costi Gustavo R Source Type: research
