Comparison of fracture strength, surface hardness, and color stain of conventionally fabricated, 3D printed, and CAD-CAM milled interim prosthodontic materials after thermocycling
CONCLUSION: 3D printing and CAD-CAM milled interim materials showed better fracture strength. After the coffee thermal cycle, the highest surface hardness value was again found in 3D printing and CAD-CAM milled interim samples and the color change of the bis-acryl resin-based samples and the additive production technique was higher than the PMMA resin and CAD-CAM milled resin samples.PMID:38694194 | PMC:PMC11058348 | DOI:10.4047/jap.2024.16.2.115 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Mesut Y ıldırım Filiz Aykent Mahmut Serta ç Özdoğan Source Type: research
< em > In vitro < /em > profiling and molecular dynamics simulation studies of berberine loaded MCM-41 mesoporous silica nanoparticles to prevent neuronal apoptosis
This study thoroughly examines the production and characterization of MCM-41 based berberine (BBR)-loaded porous silica nanoparticles (MSNs) by a modified Stöber method, focusing on their possible role in inhibiting the apoptotic process. Particle size, polydispersity index, morphology, drug loading, zeta potential, entrapment efficiency, and drug release were examined. The formulation was analyzed using various spectroscopic techniques. The surface area was computed by the Brunauer-Emmett-Teller plot. Computational models were developed for molecular dynamics simulation studies. A small PDI value indicated an even distri...
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Anurag Kumar Singh Snigdha Singh Tarun Minocha Sanjeev Kumar Yadav Reema Narayan Usha Yogendra Nayak Santosh Kumar Singh Rajendra Awasthi Source Type: research
Structured medication reviews in Parkinson's disease: pharmacists' views, experiences and needs - a qualitative study
CONCLUSION: Although community pharmacist-led SMRs are time-consuming and sometimes logistically challenging, they are of added value in primary care in general, and also in PD, of which treatment occurs mainly in secondary care. It emphasizes the pharmacist's role in PD treatment and might tackle future drug-related issues. Improvements concern multidisciplinary collaboration for optimized SMR execution and results.PMID:38694547 | PMC:PMC11062216 | DOI:10.1177/20420986241237071 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Nicol G M Oonk Lucille D A Dorresteijn Eline Te Braake Kris L L Movig Job van der Palen Henk-Willem Nijmeijer Mirjam E van Kesteren Christina Bode Source Type: research
Leveraging digital assets: lessons from a 14-year-old isotope tracer course for professional scientists
Adv Physiol Educ. 2024 May 2. doi: 10.1152/advan.00073.2023. Online ahead of print.ABSTRACTThe COVID-19 pandemic and subsequent policies (e.g., social distancing, travel restrictions) challenged both organizers for and attendees of programs typically held in-person. Many scientific training programs quickly adapted to virtual formats by incorporating digital assets developed for virtual learning and remote social engagement. At the outset, the value of continuing digital elements with future in-person events was unclear. To examine how virtual resources supported heterogeneous professional training programs, we reviewed su...
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Eann Malabanan Owen P McGuinness Kendra H Oliver Source Type: research
The International System for Reporting Serous Fluid Cytopathology: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies
Adv Anat Pathol. 2024 May 2. doi: 10.1097/PAP.0000000000000454. Online ahead of print.ABSTRACTThis is the first systematic review and meta-analysis of The International System (TIS) for reporting serous fluid cytopathology. Our aims were to present the pooled malignancy rate of each TIS reporting category and the diagnostic accuracy of cytology using this system. Database search using a predefined strategy was followed by study selection, data extraction, study quality assessment, and statistical analysis. Data derived from 16 eligible studies were pooled. The pooled rates of malignancy were as follows: 27% (95% CI; 16%-41...
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Fatima E Jamal Johannes A Vey Tanja Proctor Angela Ishak Fernando C Schmitt Ilias P Nikas Source Type: research
Observing the Clinical Course of Duchenne Muscular Dystrophy in Medicaid Real-World Healthcare Data
CONCLUSIONS: This study is the first to use diagnosis and procedure codes from real-world Medicaid claims to document the clinical course in DMD. Findings were consistent with previously published estimates from commercially insured populations and clinical registries; and contribute to the expanding body of real-world evidence around clinical progression of patients with DMD.PMID:38698169 | DOI:10.1007/s12325-024-02865-2 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Christina Qian Alexa C Klimchak Shelagh M Szabo Evan Popoff Susan T Iannaccone Katherine L Gooch Source Type: research
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry
Adv Sci (Weinh). 2024 Apr 30:e2400594. doi: 10.1002/advs.202400594. Online ahead of print.ABSTRACTProteolysis targeting chimeras (PROTACs) have emerged as a promising strategy for drug discovery and exploring protein functions, offering a revolutionary therapeutic modality. Currently, the predominant approach to PROTACs discovery mainly relies on an empirical design-synthesis-evaluation process involving numerous cycles of labor-intensive synthesis-purification and bioassay data collection. Therefore, the development of innovative methods to expedite PROTAC synthesis and exploration of chemical space remains highly desired...
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Ke-Nian Yan Yong-Qiang Nie Jia-Yu Wang Guang-Liang Yin Qia Liu Hao Hu Xiaoxia Sun Xiao-Hua Chen Source Type: research
Autonomous Artificial Olfactory Sensor Systems with Homeostasis Recovery via a Seamless Neuromorphic Architecture
This article is protected by copyright. All rights reserved.PMID:38689548 | DOI:10.1002/adma.202400614 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Young-Woo Jang Jaehyun Kim Jaewon Shin Jeong-Wan Jo Jong Wook Shin Yong-Hoon Kim Sung Woon Cho Sung Kyu Park Source Type: research
Upcycling of sugar refining mud solid waste as a novel adsorbent for removing methylene blue and Congo red from wastewater
RSC Adv. 2024 Apr 30;14(19):13505-13520. doi: 10.1039/d4ra01451k. eCollection 2024 Apr 22.ABSTRACTThe feasibility of utilizing the mud solid waste (MSW) produced during the carbonation process of sugar refining as a cost-effective and environmentally friendly alternative for the water removal of methylene blue (MB) and Congo red (CR), being highly utilized organic dyes representing cationic and anionic species, respectively is presented. Prior to its use, the MSW was dried at 110 °C for 24 h and sieved through a 100-mesh screen. The chief constituent of the MSW utilized was CaCO3, with a point of zero charge (PZC) found a...
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Aly Reda Aly Abdel-Ghafar El-Demerdash Wagih Sadik Essam El Rafy Tamer Shoeib Source Type: research
Origin of < sup > 17 < /sup > O NMR chemical shifts based on molecular orbital theory: paramagnetic terms of the pre- α, α and β effects from orbital-to-orbital transitions, along with the effects from vinyl, carbonyl and carboxyl groups
RSC Adv. 2024 Apr 30;14(20):14340-14356. doi: 10.1039/d4ra00843j. eCollection 2024 Apr 25.ABSTRACT17O NMR chemical shifts (δ(O)) were analysed based on the molecular orbital (MO) theory, using the diamagnetic, paramagnetic and total absolute magnetic shielding tensors (σd(O), σp(O) and σt(O), respectively). O2- was selected as the standard for the analysis. An excellent relationship was observed between σd(O) and the charges on O for O6+, O4+, O2+, O0 and O2-. The data from H2O, HO+, HO- and H3O+ were on the correlation line. However, such relationship was not observed for the oxygen species, other than above. The pre...
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Keigo Matsuzaki Satoko Hayashi Waro Nakanishi Source Type: research
Antiviral activity of sulphated specialized metabolites from sea urchin < em > Clypeaster humilis < /em > : < em > in vitro < /em > and < em > in silico < /em > studies
RSC Adv. 2024 Apr 30;14(20):14185-14193. doi: 10.1039/d4ra01966k. eCollection 2024 Apr 25.ABSTRACTChemical investigations of the sea urchin Clypeaster humilis has led to separation of twelve compounds including one new sulfonic acid derivative (7R) tridec-1-en-7-yl hydrogen sulphate (1), first isolated from natural source, pyridine-3-yl methane sulfonate (2), and first isolated from marine organisms, boldine (12), in addition to nine known compounds (3-11), which were isolated for the first time from the genus Clypeaster. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR), HR-ESI-MS as well as...
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Fahd M Abdelkarem Hamdy K Assaf Yaser A Mostafa Aldoushy Mahdy Modather F Hussein Samir A Ross Nesma M Mohamed Source Type: research
Three-year follow-up analysis of phase 1/2 study on tirabrutinib in patients with relapsed or refractory primary central nervous system lymphoma
CONCLUSIONS: The results demonstrated the long-term clinical benefit of tirabrutinib, with deep and durable response in a subset of patients and acceptable safety profile, while KPS and QoL scores were maintained.PMID:38690230 | PMC:PMC11059299 | DOI:10.1093/noajnl/vdae037 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Hajime Yonezawa Yoshitaka Narita Motoo Nagane Kazuhiko Mishima Yasuhito Terui Yoshiki Arakawa Katsunori Asai Noriko Fukuhara Kazuhiko Sugiyama Naoki Shinojima Arata Aoi Ryo Nishikawa Source Type: research
Mortality, bone density and grip strength: lessons from the past and hope for the future?
CONCLUSION: We report strong relationships between grip strength and mortality compared with BMD. We hypothesize that this may reflect better recognition and treatment of low BMD in this cohort.PMID:38690291 | PMC:PMC11057971 | DOI:10.1093/rap/rkae046 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Leo D Westbury Faidra Laskou Harnish P Patel Cyrus Cooper Elaine M Dennison Source Type: research
Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course
CONCLUSIONS: In this cohort study of patients with brain metastases completing SRS, neurologic symptoms at ITCP is prognostic for OS. This data informs post-SRS surveillance in clinical practice as well as future prospective studies needed in the modern management of brain metastases.PMID:38690297 | PMC:PMC11059392 | DOI:10.1016/j.adro.2024.101475 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Jim X Leng David J Carpenter Christina Huang Jamiluddin Qazi Muzamil Arshad Trey C Mullikin Zachary J Reitman John P Kirkpatrick Scott R Floyd Peter E Fecci Steven J Chmura Julian C Hong Joseph K Salama Source Type: research
Persistence and Adherence to PCSK9 Inhibitor Monoclonal Antibodies Versus Ezetimibe in Real-World Settings
CONCLUSIONS: These data suggest approaches to increase persistence and adherence to PCSK9i mAb and ezetimibe should be implemented prior to or within 182 days following treatment initiation.PMID:38691317 | DOI:10.1007/s12325-024-02868-z (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Paul Muntner Lama Ghazi Jenna Jones Nafeesa Dhalwani Bharat Poudel Ying Wen Ligong Chen Zhixin Wang Vera Bittner Bethany Kalich Michael E Farkouh Mark Woodward Lisandro D Colantonio Robert S Rosenson Source Type: research
