Xanthine oxidase inhibitory activity of Euphorbia peplus L. phenolics
CONCLUSION: In vitro, in vivo and computational investigations showed the XO inhibitory activity of E. peplus phenolics. These phenolics might represent promising candidates for the development of XO inhibitors.PMID:34151757 | DOI:10.2174/1386207324666210609104456 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 21, 2021 Category: Chemistry Authors: Emadeldin M Kamel Noha A Ahmed Ashraf A El-Bassuony Omnia E Hussein Barakat Alrashdi Sayed A Ahmed Al Mokhtar Lamsabhi Ayman M Mahmoud Hany H Arab Source Type: research

Facile and Novel Synthesis of Spiky Gold Nanoparticles as an Efficient Antimicrobial Agent against Pseudomonas Aeruginosa
CONCLUSION: This work consists of the novel synthesis of SGNPs via a safe and simple reduction method. The synthesized SGNPs exhibit strong antibacterial activity against the Gram-negative bacteria Pseudomonas aeruginosa measured using a microplate assay test. The result showed that these SGNPs are ideal for biomedical applications.PMID:34139978 | DOI:10.2174/1386207324666210617163037 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 18, 2021 Category: Chemistry Authors: Farooq Aziz Muhammad Rashid Mubashar Rehman Muhammad Rafique Muhammad Imran Source Type: research

Facile and Novel Synthesis of Spiky Gold Nanoparticles as an Efficient Antimicrobial Agent against Pseudomonas Aeruginosa
CONCLUSION: This work consists of the novel synthesis of SGNPs via a safe and simple reduction method. The synthesized SGNPs exhibit strong antibacterial activity against the Gram-negative bacteria Pseudomonas aeruginosa measured using a microplate assay test. The result showed that these SGNPs are ideal for biomedical applications.PMID:34139978 | DOI:10.2174/1386207324666210617163037 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 18, 2021 Category: Chemistry Authors: Farooq Aziz Muhammad Rashid Mubashar Rehman Muhammad Rafique Muhammad Imran Source Type: research

Facile and Novel Synthesis of Spiky Gold Nanoparticles as an Efficient Antimicrobial Agent against Pseudomonas Aeruginosa
CONCLUSION: This work consists of the novel synthesis of SGNPs via a safe and simple reduction method. The synthesized SGNPs exhibit strong antibacterial activity against the Gram-negative bacteria Pseudomonas aeruginosa measured using a microplate assay test. The result showed that these SGNPs are ideal for biomedical applications.PMID:34139978 | DOI:10.2174/1386207324666210617163037 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 18, 2021 Category: Chemistry Authors: Farooq Aziz Muhammad Rashid Mubashar Rehman Muhammad Rafique Muhammad Imran Source Type: research

Molecular Chemo-Biological Effects
Comb Chem High Throughput Screen. 2021;24(6):743. doi: 10.2174/138620732406210503132214.NO ABSTRACTPMID:34126885 | DOI:10.2174/138620732406210503132214 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 15, 2021 Category: Chemistry Authors: Ahmed A Allam Source Type: research

Molecular Chemo-Biological Effects
Comb Chem High Throughput Screen. 2021;24(6):743. doi: 10.2174/138620732406210503132214.NO ABSTRACTPMID:34126885 | DOI:10.2174/138620732406210503132214 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 15, 2021 Category: Chemistry Authors: Ahmed A Allam Source Type: research

Molecular Chemo-Biological Effects
Comb Chem High Throughput Screen. 2021;24(6):743. doi: 10.2174/138620732406210503132214.NO ABSTRACTPMID:34126885 | DOI:10.2174/138620732406210503132214 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 15, 2021 Category: Chemistry Authors: Ahmed A Allam Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research

Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance. These findings will contribute to the development of novel therapies for melanoma.PMID:34082668 | DOI:10.2174/1386207324666210603152044 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yue Qi GuiE Ma Source Type: research

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors
CONCLUSION: The lead molecules TMf and TMh with multi-functional nature can be further employed for the treatment of various neurodegenerative disorders and depressive states.PMID:34082669 | DOI:10.2174/1386207324666210603125452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Naseer Maliyakkal Ipek Baysal Anandkumar Tengli Gulberk Ucar Mohammad Ali Abdullah Almoyad Della Grace Thomas Parambi Nicola Gambacorta Orazio Nicolotti Asmy Appadath Beeran Bijo Mathew Source Type: research

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer
CONCLUSIONS: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.PMID:34082670 | DOI:10.2174/1386207324666210603122718 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Feng Jiang Chuyan Wu Ming Wang Ke Wei Jimei Wang Source Type: research

Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric Cancer in South Indian Tamil Population
Comb Chem High Throughput Screen. 2021 Jun 3. doi: 10.2174/1386207324666210603120320. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer (GC) remains a major global health problem due to a poor understanding of its progression at the molecular level and a lack of early detection or diagnosis. Early detection is highly crucial for improving prognosis. The incidence of GC is very high in countries like India due to the limitations among the established biomarkers for GC owing to poor sensitivity and specificity.OBJECTIVE: To identify the novel biomarkers from serum samples obtained from GC patients when compared with h...
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Ananthi Sivagnanam Balasankar Thangasamy Vignesh Nagarajan Subeksha Govindarajan Ravi Jeevitha Chithra Madhesh Manikandan Athilinga Perumal Premkumar Karunakaran Megala Jayaraman Source Type: research

FABP1 gene variant associated with risk of metabolic syndrome
CONCLUSION: The present study shows that C allele in the FABP1 variant can be associated with an increased risk of MetS. The evaluation of these factors in a larger population may help further confirm these findings.PMID:34082672 | DOI:10.2174/1386207324666210603114434 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Reza Zare-Feyzabadi Majid Mozaffari Majid Ghayour-Mobarhan Mohsen Valizadeh Source Type: research

Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China
CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 4, 2021 Category: Chemistry Authors: Yu-Qin Deng Song Li Zheng-Yan Liang Fen Li Si-Lu Wen Ze-Zhang Tao Source Type: research