Transcriptome-wide association study identifies genetically dysregulated genes in diabetic neuropathy.
In this study, we attempted to identify diabetic neuropathy-specific genes from reliable large-scale genome-wide association studies (GWASs) for diabetes per se. METHODS: Taking advantage of publicly available data, we initially converted the GWAS signals to transcriptomic profiles in the tibial nerve using the functional summary-based imputation (FUSION) algorithm. The FUSION-derived genes were then checked to determine whether they were differentially expressed in the sciatic nerve of mouse models of diabetic neuropathy. The dysregulated genes identified in the sciatic nerve were explored in the blood of patients. ...
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Lan D, Jiang HY, Su X, Zhao Y, Du S, Li Y, Bi R, Zhang DF, Yang Q Tags: Comb Chem High Throughput Screen Source Type: research

Variations in Mineral/heavy metals profiling and preventive role of trichomes in Peach Fruits treated with CaC2.
CONCLUSION: Conclusively, the artificial ripening with CaC2 changed the nutritional value of peach fruits that has higher health risks if consume with the peel. According to our best knowledge, this is the first report that highlights the effects of CaC2 which deteriorate the nutritional value of peach fruits in Pakistan. PMID: 32772907 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Irfan M, Abbas S, Azhar BJ, Ahmad S, Muhammad H, Ahmed I, Hussain J, Shakeel SN Tags: Comb Chem High Throughput Screen Source Type: research

Nickel(II) Chromite Nanoparticles: An Eco-Friendly and Reusable Catalyst for Synthesis of 2,4-Diamino-6-aryl-pyrimidine-5-yl Cyanides under Ultrasonic Radiation.
CONCLUSION: In conclusion, a simple, efficient, and green synthesis of 2,4-diamino-6-aryl-pyrimidine-5-yl cyanides was developed using NiCr2O4 NPs as green nanocatalyst, and under ultrasound radiation as green tool. The mild reaction conditions, avoiding the use of toxic solvents or reagents, high atom economy, high yields, and simple work-up are the attractive features of this new protocol. PMID: 32772908 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Saeedi B, Abdolmohammadi S, Mirjafary Z, Kia-Kojoori R Tags: Comb Chem High Throughput Screen Source Type: research

Evaluation of insulin resistance induced brain tissue dysfunction in obese dams and their neonates: Role of ipriflavone amelioration.
CONCLUSION: Regarding steatohepatitis, the present study confirmed the anti-inflammatory effects of the ipriflavone (IP). Therefore, future studies should focus on hepatic fatty acid uptake, hepatic lipogenesis, and fatty acid oxidation and the role of IP in regulating hepatic fat metabolism. In addition, natural products like IP could be combined with the highly used pharmaceutical drugs to reduce the side effects of nonalcoholic steatohepatitis, and minimize progression of dementia. Moreover, present study supports further attempts to heal the neural dysfunction via antioxidant and anti-inflammatory cascade activities us...
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Gad RA, Abdel-Reheim ES, Shehab GMG, Hafez HS, Abuelsaad ASA Tags: Comb Chem High Throughput Screen Source Type: research

Exploration of the Potential Mechanism of Calculus Bovis in Treatment of Primary Liver Cancer by Network Pharmacology.
CONCLUSION: In summary, the current study combines network pharmacology and in vitro experiments to reveal the mechanism of CB against PLC. We concluded that 11 ingredients of CB have an anti-PLC effect. Furthermore, CB plays a key role in treating PLC mainly by apoptosis-related pathways and immune-related pathways. Our experiment verifies that CB promotes the apoptosis of SMMC-7721. PMID: 32772910 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Zhang Z, Zeng P, Gao W, Wu R, Deng T, Chen S, Tian X Tags: Comb Chem High Throughput Screen Source Type: research

Screening of Hub Gene Targets for Lung Cancer via Microarray Data.
Abstract BACKGROUND: Lung cancer is one of the malignancies exhibiting the fastest increase in morbidity and mortality, but the cause is not clearly understood. The goal of this investigation was to screen and identify relevant biomarkers of lung cancer. METHODS: Publicly available lung cancer data sets, including GSE40275 and GSE134381, were obtained from the GEO database. The repeatability test for data was done by principal component analysis (PCA), and a GEO2R was performed to screen differentially expressed genes (DEGs), which were all subjected to enrichment analysis. Protein-protein interactions (PPIs)...
Source: Combinatorial Chemistry and High Throughput Screening - August 8, 2020 Category: Chemistry Authors: Su C, Liu WX, Wu LS, Dong TJ, Liu JF Tags: Comb Chem High Throughput Screen Source Type: research

Comprehensive Profile Analysis Identifies Three Key Genes Related to Stemness in Thyroid Carcinoma.
Abstract BACKGROUND: Tumor heterogeneity imposes great challenges on cancer treatment. Cancer stem cells (CSCs) are a primary factor in initiating tumor occurrence. However, the mechanisms stem cells in the growth of thyroid cancer (TCHA) are still unclear. METHODS: Key genes regulating the stemness characteristics of THCA were identified by combining gene expressions of samples from the Cancer Genome Atlas (TCGA) and machine learning-based methods to establish an mRNA expression stemness index (mRNAsi). The relationships between mRNAsi, THCA clinical features and molecular subtypes were analyzed. Next, mRNAs...
Source: Combinatorial Chemistry and High Throughput Screening - August 6, 2020 Category: Chemistry Authors: Zhang T, Yan C, Ye Z, Yin X, Jiang TA Tags: Comb Chem High Throughput Screen Source Type: research

Theoretical Study of the Molecular Mechanism of Maxingyigan Decoction Against COVID-19: Network Pharmacology-based Strategy.
CONCLUSION: The hub genes of COVID-19 helped to reveal the underlying pathogenesis and therapeutic targets of COVID19. This study represents the first report on the molecular mechanism of MXYG decoction against COVID-19. PMID: 32767929 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - August 6, 2020 Category: Chemistry Authors: Wang M, Fu D, Yao L, Li J Tags: Comb Chem High Throughput Screen Source Type: research

Discovery of Potent SARS-CoV-2 Inhibitors from Approved Antiviral Drugs via Docking Screening.
CONCLUSION: These promising drugs could inhibit the replication of the virus; hence, we suggest the repurposing of these compounds for thetreatment of COVID-19. No toxicity measurements are required for these drugs since they were previously tested prior to their approval by the FDA. However, the assessment of these potential inhibitors as clinical drugs involves further in vivo tests for these drugs. PMID: 32748740 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 30, 2020 Category: Chemistry Authors: Chtita S, Belhassan A, Aouidate A, Belaidi S, Bouachrine M, Lakhlifi T Tags: Comb Chem High Throughput Screen Source Type: research

Uncovering Active Ingredients and Mechanisms of Spica Prunellae in the Treatment of Colon Adenocarcinoma: A Study Based on Network Pharmacology and Bioinformatics.
CONCLUSION: In this study, active ingredients and mechanism of SPin the treatment of COAD were systematically dis-cussed, which providedthe foundation for further experimental studies and mightact to promote its appropriate clinical application. PMID: 32748741 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 30, 2020 Category: Chemistry Authors: Lei Y, Yuan H, Gai L, Wu X, Luo Z Tags: Comb Chem High Throughput Screen Source Type: research

A five-microRNA signature as risk stratification system in uterine corpus endometrial carcinoma.
CONCLUSIONS: We proposed and validated a five-miR signature that could serve as an independent prognostic predictor of UCECs. PMID: 32748742 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 30, 2020 Category: Chemistry Authors: Chen Z, Huang X, Lv Y, Fang Y, Pan L, Gan Z, Huang Z, Wei W Tags: Comb Chem High Throughput Screen Source Type: research

Evaluation of the oxidative stress level and serum prolidase activity in patients with sleep bruxism.
CONCLUSION: The increased TOS, OSI and prolidase levels and decreased TAS levels could be assumed to result in oxidative injury in patients with sleep bruxism. However, the study could not determine whether oxidative imbalance and increased serum prolidase levels could be a cause or a result of bruxism. PMID: 32729414 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 28, 2020 Category: Chemistry Authors: Ozcan-Kucuk A, Ege B, Koparal M, Gonel A, Koyuncu I Tags: Comb Chem High Throughput Screen Source Type: research

Screening of significant biomarkers related with prognosis of cervical cancer and functional study based on lncRNA-associated ceRNA regulatory network.
CONCLUSION: The signature lncRNAs can help improve our understanding of the development and recurrence of CESC and the nomogram recurrence rate model can be applied to predict the survival rate of CESC patients in clinical practice. PMID: 32729415 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 28, 2020 Category: Chemistry Authors: Ding H, Zhang L, Zhang C, Song J, Jiang Y Tags: Comb Chem High Throughput Screen Source Type: research

Development and Validation of a Five-immune gene pair Signature in Endometrial carcinoma.
Abstract BACKGROUND: Endometrial cancer (EC) is a common gynecological malignancy worldwide. Immunity is closely related to occurrence and prognosis of EC. At the same time, immune-related genes have great potential as prognostic mark-ers in many types of cancer. OBJECTIVE: Therefore, we attempts to develop immune-related gene markers to enhance prognosis prediction of EC. METHODS: 542 samples of EC gene expression data and clinical follow-up information from were downloaded from The Cancer Genome Atlas (TCGA). The samples were randomly divided into two groups, one group as a training set (N=271), and on...
Source: Combinatorial Chemistry and High Throughput Screening - July 28, 2020 Category: Chemistry Authors: Li N, Yu K, Lin Z, Zeng D Tags: Comb Chem High Throughput Screen Source Type: research

A Novel HPLC Method for Simultaneous Determination of Methyl, Ethyl, n-propyl, Isopropyl, n-butyl, Isobutyl and Benzyl Paraben in Pharmaceuticals and Cosmetics.
NÖ Abstract The alkyl esters of p-hydroxybenzoic acid at the C-4 position, "the parabens," including methyl, ethyl, propyl, and butyl, are widely used as antimicrobial preservatives in foods, cosmetics, and pharmaceuticals. Official regulations on the use of these compounds make their analysis essential for the estimation of their exposure. On this basis, the presented study was realized to develop a simple, selective and cheap high-performance liquid chromatographic method for the quantitative determination of methyl paraben (MP), ethyl paraben (EP), n-propyl paraben (NPP), isopropyl paraben (IPP),...
Source: Combinatorial Chemistry and High Throughput Screening - July 28, 2020 Category: Chemistry Authors: Özcan S, Levent S, Can NÖ Tags: Comb Chem High Throughput Screen Source Type: research

Privileged Pharmacophore of FDA Approved Drugs in Combination with Chalcone Framework: A New Hope for Alzheimer's Treatment.
CONCLUSION: The current perspective described the recent updates of chalcone moiety linked with the pharmacophores of flurbiprofen and rivastigmine hybrids as selective ChE/MAO-B inhibitors for the prophylactic agents for AD. PMID: 32723232 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 28, 2020 Category: Chemistry Authors: Mathew B Tags: Comb Chem High Throughput Screen Source Type: research

Could Targeting HMGB1 be useful for the Clinical Management of COVID-19 Infection?
u İC Abstract Since the high mobility group box-1 (HMGB1) molecule had been recognized as a pro-inflammatory cytokine, which mediates endotoxin lethality of mice; there have been lots of papers about targeting the HMGB1 within the contexts of infection, inflammation, and cancer. The pathogenic impact of HMGB1 to the severe acute respiratory syndrome (SARS) and disease management with herbal formulations targeting this unique protein have already been proposed. However, the failure of the numerous current anti-viral therapies on the ongoing viral infections casts reappraisal of the possible interrelationships rega...
Source: Combinatorial Chemistry and High Throughput Screening - July 27, 2020 Category: Chemistry Authors: Çelebier M, Haznedaroğlu İC Tags: Comb Chem High Throughput Screen Source Type: research

Host -directed Therapy: A New Arsenal to Come.
Abstract The emergence of drug-resistant strains among the variety of pathogens worsens the situation in today's scenario. In such a situation, there is a very heavy demand for developing the new antibiotics has arisen, but unfortunately, very lim- ited success has been achieved in this arena till now. Infectious diseases usually make their impression in the form of severe pathology. Intracellular pathogens use the host's cell machinery for their survival. They alter the gene expression of several host's pathways and endorse to shut down the cell's innate defense pathway like apoptosis and autophagy. Intracellular...
Source: Combinatorial Chemistry and High Throughput Screening - July 27, 2020 Category: Chemistry Authors: Mohan M, Bhattacharya D Tags: Comb Chem High Throughput Screen Source Type: research

Voltammetric analysis of ephedrine in pharmaceutical dosage forms and urine using poly(Nile blue A) modified glassy carbon electrode.
CONCLUSION: The recovery studies in both pharmaceutical dosage forms and urine showed that the proposed method ensured good selectivity, precision and accuracy without any interference from inactive excipients. PMID: 32718283 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 26, 2020 Category: Chemistry Authors: Ağin F, Öztürk G, Kul D Tags: Comb Chem High Throughput Screen Source Type: research

Viral Evolution will Automatically Resolve COVID-19 Pandemic.
PMID: 32713339 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 24, 2020 Category: Chemistry Authors: Sharma D Tags: Comb Chem High Throughput Screen Source Type: research

Efficient Production of Light Olefin Based on Methanol Dehydration: Simulation and Design Improvement.
CONCLUSION: The effect of the various parameters on the ethylene production was investigated. Eventually, ethylene is produced with a purity of 95.5 % in the improved design, and thermal integration was performed to minimize energy consumption. PMID: 32691703 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Abdoli SM, Kianinia M Tags: Comb Chem High Throughput Screen Source Type: research

Protein-protein interaction and molecular dynamics of Iturin A gene on effector proteins Phytophthora infestans.
CONCLUSION: Altogether the protein-protein interaction and simulation study propose a new methodology and intern it also attempted to uncover possible antifungal activity of iturin A against effector proteins of P. infestans. PMID: 32691704 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Kumbar B, Kandagalla S, Bharath B R, Sharath B S, Mahmood R Tags: Comb Chem High Throughput Screen Source Type: research

Investigation of Targeting Relationship between Micro-Rna-22 and Vegfr3 in Lung Squamous Cell Carcinoma.
CONCLUSION: We assumed that the abnormal expression of miR-22 in lung squamous cell carcinoma may be involved in the development and progression of lung squamous cell carcinoma. MiR-22 negatively regulated the target gene VEGFR3 to mediate lymphangiogenesis. The expression of miR-22 may also be linked to the prognosis of the disease. PMID: 32691705 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Dong Z, Xu QH, Zhu YB, Wang YF, Xiong J, Dang S Tags: Comb Chem High Throughput Screen Source Type: research

Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients.
CONCLUSION: Experiments have shown that the levels of these proteins increase significantly in hydrocephalus patients compared to the healthy group. These three parameters can be considered as important markers in the diagnosis of hydrocephalus. PMID: 32691706 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Guzelcicek A, Gönel A, Koyuncu I, Cigdem G, Kose D, Karadag M, Cadirci D Tags: Comb Chem High Throughput Screen Source Type: research

Development of Spectrophotometric and Validated Stability-Indicating RP-HPLC Methods for Simultaneous Determination Of Ephedrine HCL, Naphazoline HCL, Antazoline HCL, and Chlorobutanol In Pharmaceutical Pomade Form.
CONCLUSION: The LOD values were found to be 3.95, 0.19, 0.92 and 0.96 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in spectrophotometric method, respectively. The linear ranges in the RP-HPLC method were 8.2-24.36 µg mL-1, 0.083 - 0.75 µg/mL, 2.01-7.5 µg mL-1 and 2.89 - 24.4 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO, respectively. The LOD values in the validation studies were 2.7, 0.025, 0.66 and 0.86 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in RP-HPLC method respectively. The results of the spectrophotometric and chromatographic methods were compared and no differences were...
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Dindar ÇK, Erkmen C, Uslu B, Göğer NG Tags: Comb Chem High Throughput Screen Source Type: research

Pollen Beads: A New Carrier for Propolis Active Compounds.
CONCLUSION: It could be concluded that the product obtained, pollen-propolis beads, could be considered as more valuable healthy product since the synergistic action of pollen and propolis. PMID: 32691708 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Keskin Ş, Trusheva B, Keskin M, Popova M, Kolaylı S, Bankova V Tags: Comb Chem High Throughput Screen Source Type: research

Positive Role of Synthesis Method and Hard Template on the Catalytic Performance of SAPO-34 in Methanol to Olefin Reaction.
Abstract In the present study, SAPO-34 particles were synthesized using hydrothermal (HT) and dry gel (DG) conversion methods in the presence of diethyl amine (DEA) as an organic structure directing agent (SDA). Carbon nanotubes (CNT) were used as hard template in the synthesis procedure to introduce transport pores into the structures of the synthesized samples. The synthesized samples were characterized with different methods to reveal effects of synthesis method and using hard template on their structure and catalytic performance in methanol to olefin reaction (MTO). DG conversion method results in smaller part...
Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2020 Category: Chemistry Authors: Rimaz S, Katal R Tags: Comb Chem High Throughput Screen Source Type: research

An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action.
CONCLUSION: There is convincing evidence to suggest that the selected drugs have promising actions against diabetes and its complications. Also, none of the studies has reported any adverse effects with the drugs. Also, there is evidence to suggest that the method of usage described in Unani medicine may reduce or eliminate adverse events if any. Further, there is a great need to do more research on making medicine more effective. Besides, the review article is useful for treating patients effectively by advancing the research. PMID: 32679015 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and Hig...
Source: Combinatorial Chemistry and High Throughput Screening - July 17, 2020 Category: Chemistry Authors: Fazil M, Nikhat S, Ali I Tags: Comb Chem High Throughput Screen Source Type: research

Pathophysiological effects of sulfur mustard on skin and its current treatments: possible application of phytochemicals.
CONCLUSION: Phytochemicals and herbal extracts with anti-bacterial, anti-inflammatory and anti-oxidant properties have been recently shown to hold therapeutic promise against SM-induced cutaneous complications. The current review elaborates on the possible application of herbal medicines in the healing of SM-induced injuries. PMID: 32679016 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 17, 2020 Category: Chemistry Authors: Hassanpour M, Hajihassani F, Abdollahpourasl M, Cheraghi O, Aghamohamadzade N, Rahbargazi R, Nouri M, Pilehvar-Soltanahmadi Y, Zarghami N, Akbarzadeh A, Panahi Y, Sahebkar A Tags: Comb Chem High Throughput Screen Source Type: research

An E-nose and Convolution Neural Network based Recognition Method for Processed Products of Crataegi Fructus.
CONCLUSION: The method proposed in this paper is effective for the identification of Fructus Grataegi processed products. PMID: 32669076 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 15, 2020 Category: Chemistry Authors: Wang T, Chao Y, Yin F, Yang X, Hu C, Hu K Tags: Comb Chem High Throughput Screen Source Type: research

Effects of Desilication in NaOH/Piperidine Medium and Phosphorus Modification on the Catalytic Activity of HZSM-5 Catalyst in Methanol to Propylene Conversion.
Conclusion: The findings showed alkaline treatment in NaOH/piperidine solution created uniform mesoporosity with no severe damage in the crystal structure. Similarly, phosphorus modification developed the acidic features and led to the optimal catalytic efficiency in terms of maximum propylene selectivity (49.16%) and propylene/ethylene (P/E) ratio (5.97) as well as the maximum lifetime of the catalyst. PMID: 32664835 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 13, 2020 Category: Chemistry Authors: Safaei E, Taghizadeh M Tags: Comb Chem High Throughput Screen Source Type: research

Lung Nodule Detection using Convolutional Neural Networks with Transfer Learning on CT Images.
CONCLUSION: Compared with other works, state-of-the-art specificity is obtained, which demonstrates that the proposed method is effective and applicable to lung nodule detection. PMID: 32664836 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 13, 2020 Category: Chemistry Authors: Gao J, Jiang Q, Zhou B, Chen D Tags: Comb Chem High Throughput Screen Source Type: research

Ethanol-Drop Grinding Approach: Cadmium Oxide Nanoparticles Catalyzed Synthesis of [1,3]Dioxolo[g][1]benzopyran-6-carboxylic Acids and Pyrido[d]pyrimidine-7-carboxylic Acids.
CONCLUSION: In summary, we have developed a very simple and impressive procedure for the synthesis of 8-aryl-8H- [1,3]dioxolo[4,5-g][1]benzopyran-6-carboxylic acids and 1,3-dimethyl-2,4-dioxo-5-phenyl-1,2,3,4,5,8-hexahydropyrido[2,3- d]pyrimidine-7-carboxylic acids as biologically interesting structures in the presence of CdO NPs as an efficient recyclable heterogeneous catalyst. The remarkable advantages for the offered protocol compared with traditional methods are short reaction time, good yields of the products, and the ease of operation with simple work-up procedure. PMID: 32652906 [PubMed - as supplied by publis...
Source: Combinatorial Chemistry and High Throughput Screening - July 12, 2020 Category: Chemistry Authors: Dahi-Azar S, Abdolmohammadi S, Mokhtari J Tags: Comb Chem High Throughput Screen Source Type: research

Design and Synthesis of an Aniline Derivative with Biological Activity on Heart Failure.
CONCLUSION: This study is reported a facile method for the preparation of aniline derivatives. This method offers some advantages such as; a simple procedure, low cost, and ease of work. In addition, compound 8 showed an interesting biological activity against heart failure. This phenomenon is particularly interesting because the biological activity induced by this compound could involve a molecular mechanism different compared with other drugs used for the treatment of heart failure. PMID: 32646352 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Alejandra GE, Lauro FV, Marcela RN, Maria LR, Francisco DC, Virginia MA, Yazmin OA Tags: Comb Chem High Throughput Screen Source Type: research

Green Synthesis of Thiazole Derivatives using Multi-Component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activity.
CONCLUSION: The results of disk diffusion test showed that these compounds prevented the bacterial growth. PMID: 32646353 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Hamedani NF, Azad L, Shafiee S, Noushin A Tags: Comb Chem High Throughput Screen Source Type: research

Efficacy of Thiol disulfide Homeostasis and Ischemia Modified Albumin Values in Estimating the Degree of Difficulty for Laparoscopic Cholecystectomy.
CONCLUSION: We believe that the evaluation of thiol disulfide homeostasis and IMA parameters prior to laparoscopic cholecystectomy can be used as an effective method for predicting intraoperative difficulties. PMID: 32646354 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Akkurt G, Akkurt B, Alptekın E, Birben B, Keşkek M, Erel Ö Tags: Comb Chem High Throughput Screen Source Type: research

Electroanalytical analysis of guaifenesin on poly(acridine orange) modified glassy carbon electrode and its determination in pharmaceuticals and serum samples.
CONCLUSION: The analytical applicability of the proposed method exhibited satisfying determination results for guaifenesin from pharmaceutical dosage forms (syrup) and human serum samples without any pre-separation procedure. PMID: 32646355 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Işik H, Öztürk G, Ağin F, Kul D Tags: Comb Chem High Throughput Screen Source Type: research

Introduction of Succinimide as A Green and Sustainable Organo-Catalyst for the Synthesis of Arylidene Malononitrile and Tetrahydrobenzo[b]pyran Derivatives.
CONCLUSION: In this work, we have introduced Succinimide as a green and safe organo-catalyst for the efficient synthesis arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives. The results showed that the catalyst had excellent efficiency in green aqueous media and also the reusability of the catalyst was good. PMID: 32646356 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Hassanzadeh F, Shirini F, Mamaghani M, Daneshvar N Tags: Comb Chem High Throughput Screen Source Type: research

Simple and Fast Determination of Terbinafine in Human Urine by Dilute and Shoot HPLC-DAD Using a Core-Shell Column.
CONCLUSION: The results of this study indicate that the combination of dilute and shoot approach and core-shell column can be regarded as an advantageous application for the fast determination of terbinafine in urine. PMID: 32646357 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - July 9, 2020 Category: Chemistry Authors: Yıldırım S, Demirdaş G, Fidan M, Yaşar A Tags: Comb Chem High Throughput Screen Source Type: research

Determination of Selected Phthalates in Some Commercial Cosmetic Products By HPLC-UV.
CONCLUSION: Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and in our research in general, are DEP (1852.1 μg mL-1 ± 2192.0), DBP (691.3 μg mL-1 ± 1378.5) and DMP (340.7 μg mL-1 ±323.7) respectively. Phthalates were found in the content of all 48 cosmetic products examined, and the most detected phthalates in general average was DEP (581.7 μg mL-1 + 1405.2) with a rate of 79.2%. The unexpectedly high phthalate content in the examined cosmetic products revealed a great risk of these products on human health. The developed method is a s...
Source: Combinatorial Chemistry and High Throughput Screening - June 30, 2020 Category: Chemistry Authors: Dural E Tags: Comb Chem High Throughput Screen Source Type: research

In-Silico Factorial Screening and Optimization of Chitosan Based Gel for Urapidil Loaded Microparticle Using Reduced Factorial Design.
CONCLUSION: The principal of the study design was based on finding the prefixed set parameter values utilizing the concept of in-silico screening technique and optimization with a minimal number of trials and study expenses. It concluded that Poloxamer-188 (0.94%), chitosan (2.38%), swelling time (1.81 h), and parts of chitosan (78.51%) in a formulation batch would fulfil the predetermined parameter with specific values. PMID: 32598248 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 28, 2020 Category: Chemistry Authors: Roy H, Nayak BS, Nandi S Tags: Comb Chem High Throughput Screen Source Type: research

Rhodamine B - as New Chromophore for the Determination of Melatonin in Biological, Food, and Pharmaceutical Samples.
CONCLUSION: Utilization of Rhodamine B enlarged the linear concentration range for the assay of melatonin and decreased the detection limit, making possible the assay of melatonin in a variety of samples such as: pharmaceuticals, food, and biological samples. PMID: 32598249 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 28, 2020 Category: Chemistry Authors: Lungu-Moscalu A, Negut CC, Stefanov C, Staden RS, Bunaciu AA, Staden JFV Tags: Comb Chem High Throughput Screen Source Type: research

Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans.
CONCLUSION: Based on the data, biflavonoid acts better as anti-QS than an inhibitor of MurA enzyme while the others can be acted into both of them either therapeutic agent of anti-QS or antibacterial agent of MurA inhibitor. PMID: 32598250 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 28, 2020 Category: Chemistry Authors: Apriyanti E, Satari MH, Kurnia D Tags: Comb Chem High Throughput Screen Source Type: research

Development and Validation of an Individualized Immune Prognostic Signature for Recurrent Prostate Cancer.
Abstract BACKGROUND: Immune-related genes possess promising prognostic potential in multiple cancer types. Here, we describe the development of an immune-related prognostic signature for predicting prostate cancer recurrence. METHODS: Prostate cancer gene expression profiles for 477 prostate cases, as well as accompanying follow-up information were downloaded from The Cancer Genome Atlas (TCGA) and GEO. The samples were divided into 3 groups and immune gene sets that significantly associated with prognosis identified by evaluating the relationship between the expression of 1039 immune gene and prognosis in th...
Source: Combinatorial Chemistry and High Throughput Screening - June 27, 2020 Category: Chemistry Authors: Jin Y, Wang L, Lou H, Song C, He X, Ding M Tags: Comb Chem High Throughput Screen Source Type: research

Adsorption onto MWCNTs Coupled with Cloud Point Extraction for Dye Removal from Aqueous Solutions: Optimization by Experimental Design.
Abstract AIMS: The main aim of the study was to examine the feasibility and benefits of adsorption onto multi-walled carbon nanotubes (MWCNTs) coupled with cloud point extraction (CPE) for removal of Rhodamine B (RB) from aqueous solutions. BACKGROUND: MWCNTs offer the particular features of the ideal adsorbents for the organic dyes such as hollow tubular structure and specific surface area. Nevertheless, they suffer from the drawbacks of low dispersion in the aqueous solutions and separation inconvenience from the media. Cloud point extraction combined with the adsorption onto MWCNTs can be a promising metho...
Source: Combinatorial Chemistry and High Throughput Screening - June 18, 2020 Category: Chemistry Authors: Safa F, Osaghi B Tags: Comb Chem High Throughput Screen Source Type: research

Effect of Stachy sieboldii MIQ. supplementation on modulating gut microflora and cytokine expression in mice.
Abstract Aim and Objectvie: Intake of Stachys sieboldii MIQ. has been associated with relieving inflammation and maintaining optimal gut health function. We investigated the diversity and composition of microflora in feces of S. sieboldii MIQ.-fed mice. In addition, we evaluated the production of major cytokines (Interleukin-6 and -10) related with inflammation and fatty acid composition of several tissues. MATERIALS AND METHODS: 16S ribosomal DNA sequencing-based microbiome taxonomic profiling analysis was performed using EzBioCloud data base. The total RNA from mesenteric lymph node was isolated and then sy...
Source: Combinatorial Chemistry and High Throughput Screening - June 15, 2020 Category: Chemistry Authors: Na E, Moon KH, Lim SY Tags: Comb Chem High Throughput Screen Source Type: research

Flavonoids and other Non-Alkaloidal Constituents of Genus Erythrina: Phytochemical Review.
CONCLUSION: A vast amount of data showed that the non-alkaloidal secondary metabolites were obtained from genus Erythrina with various classes of chemical structures. Herein, approximately five hundred constituents were isolated, including flavonoids, terpenoids, saponins, phytosterols, phenols, arylbenzofurans, coumarins, alcohols, ceramides, monosugars, and fatty acid derivatives. In agreement with the previous phytochemical reports on the plants of the family Fabaceae, flavonoids make up a great percentage in the number of plants of genus Erythrina. Numerous biological activity investigations such as anti-bacteria, anti...
Source: Combinatorial Chemistry and High Throughput Screening - June 9, 2020 Category: Chemistry Authors: Son NT, Elshamy AI Tags: Comb Chem High Throughput Screen Source Type: research

Design of Novel Drug-like Molecules using Informatics Rich Secondary Metabolites Analysis of Indian Medicinal and Aromatic Plants.
CONCLUSION: The supra network of molecules and scaffolds identifies the relationship between the plant molecules and drugs. Cluster analysis of virtual library molecules showed that novel molecules had more pharmacophoric properties than toxicophoric and chemophoric properties. We also developed the DoMINE toolkit for the advancement of natural product-based drug discovery through chemoinformatics approaches. This study will be useful in developing new drug molecules from the known medicinal plant molecules. Hence, this work will encourage experimental organic chemists to synthesize these molecules based on the predicted v...
Source: Combinatorial Chemistry and High Throughput Screening - June 6, 2020 Category: Chemistry Authors: Karade D, Vijayasarathi D, Kadoo N, Vyas R, Ingle PK, Karthikeyan M Tags: Comb Chem High Throughput Screen Source Type: research

Ultrasound-promoted green synthesis of pyrido[2,1-a]isoquinoline derivatives and studies on their antioxidant activity.
CONCLUSION: In summary, multicomponent reaction of phthaladehyde, methylamine, activated acetylenic compounds, alkyl bromides and triphenylphosphine in water under ultrasonic irradiation at room temperature produced pyrido[2,1-a]isoquinoline derivatives in excellent yields. Also, Diels-Alder reaction of pyrido[2,1-a]isoquinoline derivatives with activated acetylenic compounds and triphenylphosphine under ultrasonic irradiation is investigated in two procedures. Also, the antioxidant activities of 6a, 6c, 6g and 6i were evaluated by DPPH radical scavenging and ferric reducing power analyzes. The compounds 6a exhibit excelle...
Source: Combinatorial Chemistry and High Throughput Screening - June 6, 2020 Category: Chemistry Authors: Sharafian S, Hossaini Z, Rostami-Charati F, Khalilzadeh MA Tags: Comb Chem High Throughput Screen Source Type: research

Chemical variability and antioxidant activities of the essential oils of the aerial parts of Ammoides verticillata and the roots of Carthamus caeruleus and their synergistic effect in combination.
CONCLUSION: Ammoides verticillata and Carthamus caeruleus essential oil blends can be used as a natural food preservative and alternative to chemical antioxidants. PMID: 32504498 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - June 6, 2020 Category: Chemistry Authors: Mami IR, Merad-Boussalah N, El Amine Dib M, Tabti B, Costa J, Muselli A Tags: Comb Chem High Throughput Screen Source Type: research