Analysis of miRNA-mRNA interaction network reveals gap junction beta 2 as a potential candidate gene involved in psoriatic hearing loss pathogenesis.
Abstract BACKGROUND: Recent studies have shown that patients with psoriasis, a chronic inflammatory skin disorder that may accompany serious systemic disease, are at risk of developing sudden sensorineural hearing loss. The pathogenesis remains unclear, and the mechanisms of this disorder are difficult to explore in the clinical setting due to psoriasis hearing loss's infrequent incidence. Here we are aimed to identify key candidate genes that may be involved in the pathogenesis of psoriatic hearing loss. METHOD: In the present study, through online database and literature review, we utilized microRNA-mRNA ne...
Source: Combinatorial Chemistry and High Throughput Screening - November 24, 2020 Category: Chemistry Authors: Liu Q, Wu L, Lu C, Wu D Tags: Comb Chem High Throughput Screen Source Type: research

DBP-PSSM: Combination of evolutionary profiles with the XGBoost algorithm to improve the identification of DNA-binding proteins.
CONCLUSION: The findings demonstrate that the proposed method is effective for comparing, recognizing and predicting protein sequences. The main code and datasets can download from https://github.com/GaoYa1122/FermatS. PMID: 33238837 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 24, 2020 Category: Chemistry Authors: Zhang Y, Chen P, Gao Y, Ni J, Wang X Tags: Comb Chem High Throughput Screen Source Type: research

Identification of Crucial Genes and Diagnostic Value Analysis in Major Depressive Disorder Using Bioinformatics Analysis.
CONCLUSION: Our results indicate that GSTM2, GNB4, GSTP1 and CXCL1 have potential diagnostic markers and are of great significance in clinical research and diagnostic application of MDD. This result needs a large sample study to further confirm the pathogenesis of MDD. PMID: 33238838 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 24, 2020 Category: Chemistry Authors: Gao Y, Zhao H, Xu T, Tian J, Qin X Tags: Comb Chem High Throughput Screen Source Type: research

Identification of Major Compounds and α-Amylase and α-Glucosidase Inhibitory Activity of Rhizome of Musa balbisiana Colla: An In-vitro and insilico Study.
CONCLUSION: The present in-vitro and in-silico study suggests the antihyperglycemic property of the rhizome of Musa balbisiana and possible candidate for therapeutic antidiabetic agent(s). PMID: 33234097 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 24, 2020 Category: Chemistry Authors: Swargiary A, Daimari M Tags: Comb Chem High Throughput Screen Source Type: research

Identification of Therapeutic drug Target of Stenotrophomonas maltophilia through subtractive genomic approach and in-silico screening based on 2D similarity filtration and Molecular Dynamic Simulation.
CONCLUSION: Further, in vitro and in vivo bioassay of the identified novel inhibitors could facilitate effective drug use against S.maltophilia. PMID: 33231154 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 22, 2020 Category: Chemistry Authors: Chandela R, Jade D, Mohan S, Shobana S, Sharma R Tags: Comb Chem High Throughput Screen Source Type: research

Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking studies unveils an opportunity against CORONA.
CONCLUSION: Compounds have a great potential to become COVID-19 main protease Mpro inhibitor. Nevertheless for their medicinal use further investigation is necessary. PMID: 33231155 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 22, 2020 Category: Chemistry Authors: Arif MN Tags: Comb Chem High Throughput Screen Source Type: research

Anti Ulcerogenic and Cytoprotective Effects of Saharian (Sidr) Honey from Algeria.
CONCLUSION: These results were confirmed by the histological assessment which demonstrated a significant gastro protective activity of Saharian (Sidr) honey against HCl/Ethanol-induced stomach ulcer. Plasma tumor necrosis factor-!, IL-6 and PGE2were also measured. Sahara honeys significantly decreased the plasma TNF-!, PGE2, and IL-6 concentrations. PMID: 33208062 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 16, 2020 Category: Chemistry Authors: Djebli N, Mustafa MR, Keskin M, Kolayli S Tags: Comb Chem High Throughput Screen Source Type: research

Anti-Cancer and Antibacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles.
CONCLUSION: This study shows that synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and anti-bacterial effects. PMID: 33208063 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 16, 2020 Category: Chemistry Authors: Yaghoubi H, Izadpanah A, Nedaei S, Akbari H, Agah EM, Mostany R, Chandrasekar B, Alt E, Izadpanah R Tags: Comb Chem High Throughput Screen Source Type: research

FermatS: a novel numerical representation for protein sequence comparison and DNA-binding protein identification.
CONCLUSION: The findings demonstrate that the proposed method is effective for comparing, recognizing and predicting protein sequences. The main code and datasets can download from https://github.com/GaoYa1122/FermatS.. PMID: 33208064 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 16, 2020 Category: Chemistry Authors: Zhang Y, Gao Y, Ni J, Chen P, Wang X Tags: Comb Chem High Throughput Screen Source Type: research

Network pharmacology and molecular docking approaches to investigating the mechanism of action of Zanthoxylum bungeanum in the treatment of oxidative stress-induced diseases.
CONCLUSION: The findings of this study not only indicate the main mechanisms involving in the oxidative stress-induced diseases, but also provide the basis for further research on the active components of Z. bungeanum for treating DOS. PMID: 33208065 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 16, 2020 Category: Chemistry Authors: Zhao R, Zhang MM, Wang D, Peng W, Zhang Q, Liu J, Ai L, Wu CJ Tags: Comb Chem High Throughput Screen Source Type: research

Comparison between Phenolic Content, Antioxidant and Antibacterial ac-tivity of Algerian and Turkish Propolis.
CONCLUSION: Algerian and Anatolian propolis possessed considerable phenolic and flavonoids contents. In addition, they ex-hibited an interesting antioxidant and antibacterial activities. Our finding suggest that both propolis could be useful in food and pharmaceutical industries. PMID: 33183194 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 11, 2020 Category: Chemistry Authors: Segueni N, Keskin M, Keskin Ş, Kadour B, Kolaylı S, Salah A Tags: Comb Chem High Throughput Screen Source Type: research

Nickel (II) and oxovanadium (IV) complexes supported on MCM-41 mesoporous and their application in catalytic selective sulfide and thiol oxidation.
CONCLUSION: These catalytic systems furnish the products very quickly with excellent yields and VO-6AP-MCM-41 shows high catalytic activity compared to Ni-6AP-MCM-41. PMID: 33183195 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 11, 2020 Category: Chemistry Authors: Nikoorazm M, Khanmoradi M, Sayadian M Tags: Comb Chem High Throughput Screen Source Type: research

Digraph Energy of Directed Polygons.
CONCLUSION: The n-order oriented hollow k-polygon with the maximum digraph energy among Hk(G) only contains a cycle. Moreover, such a cycle is the longest one produced in G. PMID: 33176639 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 11, 2020 Category: Chemistry Authors: Deng B, Yang N, Liang W, Lu X Tags: Comb Chem High Throughput Screen Source Type: research

The molecular diversity of 1,8-diaminonaphthalene in organic chemistry.
Abstract 1,8-diaminonaphthalene (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or four-component fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes. PMID: 33172368 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Ziarani GM, Mohajer F, Mali SN Tags: Comb Chem High Throughput Screen Source Type: research

In-silico analysis of angiotensin converting enzyme 2 (ACE2) of livestock, pet and poultry animals to determine its susceptibility to SARS-CoV- 2 infection.
CONCLUSION: Present studypredicted that SARS-CoV-2 tends to utilize ACE2s ofvarious livestock and poultry species with greater probability in equine and poor in chicken. Study may provide important insights into the animal models for SARSCoV-2 and animal management for COVID-19 control. PMID: 33172369 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Kumar A, Panwar A, Batra K, Dey S, Maan S Tags: Comb Chem High Throughput Screen Source Type: research

Receptor dynamics in molecular recognition by Cryo-EM and molecular simulation.
Abstract The appropriate selection of initial receptor structure has been the 'cornerstone' or foundation of successful structure-based virtual screening (SBVS), and plagued the structure-based design with a significantly practical problem to determine the major physiological states or important transition states of receptors (e.g. proteins with multiple low-energy conformations and ligand-dependent conformational dynamics). It is well known that current SBVS methods lack capacity to capture and characterize the intrinsic receptor flexibility with ideal cost-effectiveness. In recent years, cryoelectron microscopy ...
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Zhao Y, Wang H, Zang Y, Zhu X, Zhang S, Zhang L Tags: Comb Chem High Throughput Screen Source Type: research

Biomarker Analysis Based Chemoprofiling of Polyherbal Ayurvedic Formulation Containing Vitis vinifera L. by Validated UPLC-MS/MS Method.
CONCLUSION: The developed method was found rapid, accurate, reliable and highly sensitive for the simultaneous quantification of selected biomarkers in Drakshasava. The research is the first chemometric report in standardization of Drakshasava by validated UPLC-MS/MS method. It may prove to be useful tool for development of new phyto-pharmaceutical drug and further quality control of other poly herbal formulations. PMID: 33172371 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Goel P, Aeri V, Dewangan RP, Rub RA Tags: Comb Chem High Throughput Screen Source Type: research

Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain.
CONCLUSION: It indicates that such an interruption of electrostatic interactions between the RBD and ACE2, and the increase in global flexibility of the complex, would weaken or block SARS-CoV-2 entry and its subsequent infectivity. We postulate that natural phytochemicals like Tinocordiside could be the viable options for controlling SARS-CoV-2 contagion and its entry into host cells. PMID: 33172372 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Balkrishna A, Pokhrel S, Varshney A Tags: Comb Chem High Throughput Screen Source Type: research

Response Surface Methodology to Optimize the Combination Treatment of Paclitaxel, Bufalin and Cinobufagin for Hepatoma Therapy.
CONCLUSION: The combination of BFL and CBF synergistically enhanced the potency of PTX against HepG2 cells. RSM could give an accurate evaluation for drug interactions and efficient prediction of optimum combination. PMID: 33172373 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Zhang J, Shu C, Yi X, Zhu J, Lian X, Wu Y Tags: Comb Chem High Throughput Screen Source Type: research

Identification of a MiRNA-mRNA Regulatory Network in Colorectal Cancer.
CONCLUSIONS: Aberrant expression of genes and miRNAs were involved in the pathogenesis of CRC probably by regulating proteoglycans expression and cAMP signaling. miR-27a-3p, PCDH10, GRIN2B, FJX1, Dsc2, and hsa-miR-375 were identified as potential targets for understanding the pathogenic mechanism of CRC. In addition, FJX1, Dsc2 and hsa-miR-375 were identified as potential predictive markers for CRC prognosis. PMID: 33172374 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Cui MF, Wu YY, Chen MY, Zhao Y, Han SY, Wang RJ, Zhang H, Fang XD Tags: Comb Chem High Throughput Screen Source Type: research

A novel and sensitive LC-MS/MS method for the quantitation of ceftiofur in pharmaceutical preparations and milk samples.
CONCLUSION: Applicability of both positive and negative ion modes was tested, and the analyte was detected via multiple reaction monitoring. The distorting effects of the milk matrix on the MS ionization and quantitation of CEF were overcome by using matrix-matched calibration for the first time. PMID: 33176637 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Levent S, Özcan S, Geven A, Can NÖ Tags: Comb Chem High Throughput Screen Source Type: research

Herbal Medicine: Clinical Perspective & Regulatory Status.
Herbal Medicine: Clinical Perspective & Regulatory Status. Comb Chem High Throughput Screen. 2020 Nov 10;: Authors: Barkat MA, Goyal A, Barkat HA, Salauddin M, Pottoo FH, Anwer ET Abstract Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices based on these has its pros and cons and has been grea...
Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Barkat MA, Goyal A, Barkat HA, Salauddin M, Pottoo FH, Anwer ET Tags: Comb Chem High Throughput Screen Source Type: research

A Computational Approach for Identifying Potential Phytochemicals Against Non-structural Protein 1 (Nsp1) of SARS-CoV-2.
CONCLUSION: It is expected that this research might be helpful for the development of new antiviral drugs active against SARS-CoV-2 targeting Nsp1. PMID: 33155887 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Hossain A Tags: Comb Chem High Throughput Screen Source Type: research

Development and validation of a LC-MS/MS method for quantification of mobocertinib (TAK-788) in plasma and its application to pharmacokinetic study in rats.
CONCLUSION: The developed and validated method was successfully employed in the pharmacokinetic study in rats following oral administration of mobocertinib at the doses of 2, 6, and 18 mg/kg. PMID: 33155888 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Li B, Wang J, Dou X, Zhang X, Xue X, Xu Q, Ran W, Xiong S Tags: Comb Chem High Throughput Screen Source Type: research

Comprehensive Analysis of Transcriptomics and Metabolomics between the Heads and Tails of Angelica Sinensis: Genes Related to Phenylpropanoid Biosynthesis Pathway.
CONCLUSION: Our work demonstrated that overexpressed genes and accumulated metabolites derived from PB pathway might be responsible for the discrepant pharmaceutical efficacies between AS heads and tails. PMID: 33155889 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Yang J, Zhang C, Li WH, Zhang TE, Fan GZ, Guo BF, Yao WY, Gong DH, Peng QL, Ding WJ Tags: Comb Chem High Throughput Screen Source Type: research

Functional characterization and structural modelling of peptidoglycan degrading β-N-acetyl-glucosaminidase from a dental isolate of Serratia marcescens.
CONCLUSION: It can be concluded that enzymes belonging to this category can serve as a tool in eradicating Gram-positive pathogens and associated infections. PMID: 33155890 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Rathee A, Panwar A, Kumari S, Chhibber S, Kumar A Tags: Comb Chem High Throughput Screen Source Type: research

Hemisyntheses and In-Silico Study of New Analogues of Carlina Oxide from Carthamus Caeruleus Roots.
CONCLUSION: In fact, these new compounds could lead to powerful approaches for the research and development of new antibiotics. PMID: 33155891 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Mami IR, Amina TZ, Pérard J, Arrar Z, Dib MEA Tags: Comb Chem High Throughput Screen Source Type: research

Prediction Biomarkers Associated with Lymph Node Metastasis and Prognosis were Identified in Papillary Thyroid Carcinoma via Integrated Bioinformatics Analysis.
Abstract BACKGROUND: Prediction biomarkers associated with prognosis and lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) are needed to facilitate clinicians in choosing appropriate therapies. OBJECTIVE: We hope to identify key genes associated with LNM and prognosis in PTC. METHODS: GSE29265, GSE33630, GSE3467, GSE3678 and GSE58545 gene expression profiles were acquired from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PTC tissues and normal thyroid tissues were selected with the GEO2R tool, and common DEGs among the five datasets were integrated wi...
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Gan S, Ye R, Ha Y, Xiong Y, Li R, Di X, Zou Z, Sun Y, Zhang Z Tags: Comb Chem High Throughput Screen Source Type: research

Serum Pro-oxidant-Antioxidant Balance in subjects with Type 2 Diabetes Mellitus.
Abstract AIM AND OBJECTIVE: Diabetes mellitus is associated with inflammation and increased oxidative stress. In the current study, we aimed to investigate the relationship between type 2 diabetes mellitus (T2DM) and serum pro-oxidantantioxidant balance (PAB) in a large population-based study. METHODS: In this cross-sectional study, 7888 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Participants were divided into three groups, based on their serum PAB values (levels 82.6 HK). Serum PAB values were measured using a colorimetric method and enzyme-...
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Ahmadnezhad M, Ghazizadeh H, Bijari M, Oladi MR, Esmaily H, Hoseini SJ, Barati E, Silakhori S, Moham-Madi-Bajgiran M, Davari H, Parizadeh MR, Mokhber N, Sharifan P, Aref-Hosseini SR, Ferns GA, Moohebati M, Ghayour-Mobarhan M Tags: Comb Chem High Throughput Screen Source Type: research

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review.
CONCLUSION: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use. PMID: ...
Source: Combinatorial Chemistry and High Throughput Screening - November 2, 2020 Category: Chemistry Authors: Mohi-Ud-Din R, Mir RH, Mir PA, Farooq S, Raza SN, Raja WY, Masoodi MH, Singh IP, Bhat ZA Tags: Comb Chem High Throughput Screen Source Type: research

Thiol/Disulfide Homeostasis as an Early Biomarker to Differentiate Sepsis from Pneumonia in Intensive Care Units.
CONCLUSION: In this study, we showed that thiol/disulfide homeostasis can be used as new markers in the early period in order to separate patients with sepsis and patients with pneumonia. PMID: 33135606 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 29, 2020 Category: Chemistry Authors: Cakir E, Gok G, Erel O, Turan IO Tags: Comb Chem High Throughput Screen Source Type: research

Exploring the Potential Mechanism of Shufeng Jiedu Capsule for Treating COVID-19 by Comprehensive Network Pharmacological Approaches and Molecular Docking Validation.
CONCLUSIONS: By network pharmacology analysis, SFJDC was found to effectively improve immune function and reduce inflammatory responses based on its key compounds, hub target genes, and the relevant pathways. These findings may provide valuable evidence for explaining how SFJDC exerting the therapeutic effects on COVID-19, providing a holistic view for further clinical application. PMID: 33135607 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 29, 2020 Category: Chemistry Authors: Zhuang Z, Zhong X, Zhang H, Chen H, Huang B, Lin D, Wen J Tags: Comb Chem High Throughput Screen Source Type: research

Integrating LINCS Data to Evaluate Cancer Transcriptome Modifying Potential of Small-molecule Compounds for Drug Repositioning.
CONCLUSION: Our work establishes CTMP to evaluate the antineoplastic property of small-molecule compounds and suggests CTMP-based systematic screen of cancer type-specific CTMTs as a feasible strategy in drug repositioning for precise anticancer purposes. PMID: 33109034 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 27, 2020 Category: Chemistry Authors: Zhao Y, Liu Y, Bai H Tags: Comb Chem High Throughput Screen Source Type: research

Identification of novel prognostic biomarkers in head and neck squamous cell carcinoma using bioinformatics analysis.
CONCLUSION: We have identified five key genes that may help us understand the carcinogenic mechanisms related to the cell cycle in HNSCC. These genes may be used as biomarkers for survival and treatment of HNSCC. PMID: 33109035 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 27, 2020 Category: Chemistry Authors: Ding Y, Li M, Tayier T, Chen L, Feng S Tags: Comb Chem High Throughput Screen Source Type: research

Electroacupuncture ameliorates CUMS-induced depression-like behavior: involvement of the glutamatergic system and apoptosis in rats.
CONCLUSION: EA ameliorated depression-like behavior in CUMS rats, which might be mediated, at least in part, by regulating the glutamate, NMDA receptors and apoptosis in the hippocampus. PMID: 33109036 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 27, 2020 Category: Chemistry Authors: Guo Q, Lin XM, Di Z, Zhang QA, Jiang S Tags: Comb Chem High Throughput Screen Source Type: research

Molecular Mechanisms of Thymoquinone as Anticancer agent.
Abstract Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via inducti...
Source: Combinatorial Chemistry and High Throughput Screening - October 27, 2020 Category: Chemistry Authors: Alhmied FI, Alammar AH, Alsultan BM, Alshehri M, Pottoo FH Tags: Comb Chem High Throughput Screen Source Type: research

Mechanistic Insights to the Binding of Antibody CR3022 Against RBD from SARS-CoV and HCoV-19/SARS-CoV-2: A Computational Study.
CONCLUSION: Thus, in order to better fight the epidemic of COVID-19 with the CR3022 antibody, this antibody needs to further improve the neutralization efficiency of HCoV-19 through mutation of it's CDR region. PMID: 33106140 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 26, 2020 Category: Chemistry Authors: Yu W, Wu X, Ren J, Zhang X, Wang Y, Li C, Xu W, Zheng W, Liao H, Yuan X, Li J, Li G Tags: Comb Chem High Throughput Screen Source Type: research

Metabolic profile of dendrobine in rats determined by ultra-high performance liquid chromatography/Quadrupole time-of-flight mass spectrometry.
CONCLUSIONS: This research provides scientific and reliable support for full understanding of the metabolic fate of dendrobine in vivo. PMID: 33100199 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 23, 2020 Category: Chemistry Authors: Bai JQ, Guo QX, Zhang J, Huang J, Xu W, Gong L, Su H, Luo YB, Li JH, Qiu XH, Huang ZH Tags: Comb Chem High Throughput Screen Source Type: research

Correlative Study of Bone-Related Biochemicals and Endocrine Changes in Perimenopausal Women in Enugu, Nigeria.
Abstract BACKGROUND AND OBJECTIVE: Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical changes lead to higher incidence of metabolic syndrome (MetS) occurrence with or without bone involvement. There is scarcity of information on MetS in Enugu, Southern Nigeria and there is no available data on the correlation of selected bone-related biochemicals with endocrine parameters an...
Source: Combinatorial Chemistry and High Throughput Screening - October 23, 2020 Category: Chemistry Authors: Ikegwuonu CI, Uchendu IK, Maduka CI Tags: Comb Chem High Throughput Screen Source Type: research

Privacy-preserving Collaborative Training for Medical Image Analysis Based on Multi-Blockchain.
CONCLUSION: Our approach can effectively help researchers from different organizations to achieve collaborative training without disclosing their private data. PMID: 33092504 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 22, 2020 Category: Chemistry Authors: Zhang W, Wang Q, Li M Tags: Comb Chem High Throughput Screen Source Type: research

Explore the mechanism of Swertia mussotii Franch. for hepatoprotective effects with iTRAQ-LC-MS/MS.
CONCLUSION: SMT herb could play a role in hepatoprotection and alleviate the effect of acute liver injury by impacting the lipid metabolism associated biological process. PMID: 33081677 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2020 Category: Chemistry Authors: Yun H, Wu X, Ding Y, Xiong W, Duan X, Gao H, Yang Y, Chen Z Tags: Comb Chem High Throughput Screen Source Type: research

Pattern of calculated inflammation ratios as prognostic values in patients with colorectal cancer.
CONCLUSIONS: Patients with high NLR, postoperative complications, ischemic cardiomyopathy an d/or liver cirrhosis are the candidates to a less favorable outcome among subjects with colorectal cancer regardless the age and gender. PMID: 33081678 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2020 Category: Chemistry Authors: Cioca A, Bolboac SD, Druga C, Cioca RA, Grau F, Al Hajja N Tags: Comb Chem High Throughput Screen Source Type: research

Prognostic significance of hematopoietic-cell serglycin for survival of hepatocellular carcinoma: a single-center retrospective study.
CONCLUSION: The intensity of serglycin fluorescence in peripheral neutrophils was independently predictive of survival in HCC and its value was not limited by bacterial infection. The method presented here is a simple and feasible way to predict prognosis in HCC patients with TACE. PMID: 33081679 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2020 Category: Chemistry Authors: Li Y, Chen H, Lu H, Zou Z, Li Y Tags: Comb Chem High Throughput Screen Source Type: research

The influence of diabetes mellitus on rotator cuff repair: A systematic review and meta-analysis.
Abstract BACKGROUND: Clinical outcomes after rotator cuff repair associated with diabetes mellitus(DM) are generally favorable, but no study has attempted to establish the influence of DM on outcomes after rotator cuff repair. PURPOSE: To conduct a meta-analysis of clinical studies evaluating patient outcomes between people with DM and people without DM after rotator cuff repair. STUDY DESIGN: Meta-analysis. METHODS: A literature search of the Embase, PubMed, and Cochrane Library databases was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guid...
Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2020 Category: Chemistry Authors: Lu X, Sun H, Xu Y, Cao X Tags: Comb Chem High Throughput Screen Source Type: research

Some valency oriented molecular invariants of certain networks.
Abstract BACKGROUND: The valency of an atom in a molecular structure is the number of its neighboring atoms. A large number of valency based molecular invariants have been conceived, which correlate certain physio-chemical properties like boiling point, stability, strain energy and many more of chemical compounds. OBJECTIVE: Our aim is to study the valency based molecular invariants for four hexa chemical structures, namely hexagonal network, honeycomb network, oxide network and silicate sheet network. METHOD: We use the technique of atom-bonds partition according to the valences of atoms to find results...
Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2020 Category: Chemistry Authors: Salman M, Ali F, Masood Ur Rehman, Khalid I Tags: Comb Chem High Throughput Screen Source Type: research

Chitosan and Wnt/ β-catenin signaling pathway in different cancers.
Chitosan and Wnt/β-catenin signaling pathway in different cancers. Comb Chem High Throughput Screen. 2020 Oct 19;: Authors: Eslahi M, Sadoughi F, Asemi Z, Yousefi B, Mansournia MA, Hallajzadeh J Abstract It's been a while since the disease of cancer was discovered in 16th and 17th century but still this disease is one of the most lethal diseases in the world which is taking a great number of lives every year. Cancer statistics suggest that there are still a lot of improvements that we have to make in the field of cancer treatment in order to overcome this deadly disease. Currently, nanotechnology...
Source: Combinatorial Chemistry and High Throughput Screening - October 19, 2020 Category: Chemistry Authors: Eslahi M, Sadoughi F, Asemi Z, Yousefi B, Mansournia MA, Hallajzadeh J Tags: Comb Chem High Throughput Screen Source Type: research

Elucidation of the mechanisms and molecular targets of Qishen Yiqi formula for the treatment of pulmonary arterial hypertension using a bioinformatics/network topology-based strategy.
Abstract BACKGROUND AND OBJECTIVE: Qishen Yiqi formula (QSYQ) is used to treat cardiovascular disease in the clinical practice of traditional Chinese medicine. However, few studies have explored whether QSYQ affects pulmonary arterial hypertension (PAH), and the mechanisms of action and molecular targets of QSYQ for the treatment of PAH are unclear. A bioinformatics/network topology-based strategy was used to identify the bioactive ingredients, putative targets, and molecular mechanisms of QSYQ in PAH. METHODS: A network pharmacology-based strategy was employed by integrating active component gathering, targe...
Source: Combinatorial Chemistry and High Throughput Screening - October 19, 2020 Category: Chemistry Authors: Wu P, Xie X, Chen M, Sun J, Cai L, Wei J, Yang L, Huang X, Wang L Tags: Comb Chem High Throughput Screen Source Type: research

Evaluation of plasma free amino acid and carnitine levels in patients with cesarean scar pregnancy.
CONCLUSION: Since several plasma carnitine and FAA levels were higher in CSP group than in the control group, we think that scar pregnancy increases metabolic need for myometrial invasion. Also, we think that these results may be useful in clinical practice for CSP diagnosis. PMID: 33076805 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 19, 2020 Category: Chemistry Authors: Tammo O, Uyanikoglu H, Koyuncu İ Tags: Comb Chem High Throughput Screen Source Type: research

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents.
CONCLUSION: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli. PMID: 33076806 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 19, 2020 Category: Chemistry Authors: Khodadad H, Hatamjafari F, Pourshamsian K, Sadeghi B Tags: Comb Chem High Throughput Screen Source Type: research

A Generalized Iterative Map for Analysis of Protein Sequences.
CONCLUSION: Two examples show that our method not only has good performances and effects in the similarity/dissimilarity analysis of protein sequences but also does not require complex computation. PMID: 33045963 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 12, 2020 Category: Chemistry Authors: Huang J, Dai Q, Yao Y, He PA Tags: Comb Chem High Throughput Screen Source Type: research