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Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research

Exploring the Mechanism of KLF15 on the Biological Activity and Autophagy of Gastric Cancer Cells based on PI3K/Akt/Mtor Signaling Pathway
CONCLUSION: Overexpression of KLF15 can inhibit the proliferation and invasion of Gastric cancer cells and promote cell apoptosis and autophagy, and its mechanism may be related to the regulation of the PI3K/Akt/mTOR signaling pathway.PMID:38591199 | DOI:10.2174/0113862073255591231213053101 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Xu Wang Jiang Liu Shihang Xi Xuan Pan Xiaosan Fang Source Type: research

Nutriose, a Dextrin-based Natural Polysaccharide Polymer with Beneficial Activities as a Candidate for Future Drug Delivery: A Review
Comb Chem High Throughput Screen. 2024 Apr 5. doi: 10.2174/0113862073283113240329064552. Online ahead of print.ABSTRACTNutriose is a dextrin-based soluble fiber prepared from starch. Cereals such as maize, wheat, and barley are the primary sources of nutrients for commercial production. Nutriose is resistant to digestion by human enzymes in the stomach and small intestine. It is mostly undamaged when it enters the colon after traveling through the digestive tract, where it generates shortchain fatty acids (SCFAs) as byproducts. These SCFAs, which include butyrate, propionate, and acetate, have a number of health advantages...
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Debaprasad Ghosh Anushka Jain Mansi Tyagi Deepti Katiyar Ashu Mittal Source Type: research

ERH Impacts Patient Prognosis and Tumor Immune Microenvironment: A Pan-Cancer Analysis
CONCLUSION: Our pan-cancer analysis demonstrated the characterization of ERH in multiple tumors. ERH may be a valuable novel biological indicator for assessing immunotherapy efficacy and prognosis in various malignancies.PMID:38584561 | DOI:10.2174/0113862073295696240322084341 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Qianhui Gong Qiong Li Xiaobing Shen Zhichao Xu Source Type: research

Exploring Type II Diabetes Inhibitors from Genus Daphne Plant-species: An Integrated Computational Study
CONCLUSION: Our analysis took us to the conclusion that daphnegiralin B4 (36) among all ligands comes out to be a lead compound having drug-like properties among 38 ligands being non-carcinogenic and non-cytotoxic which would benefit the medical community by providing significant drugs against diabetes. Pragmatic laboratory investigations identified a new precursor to open new doors for new drug discovery.PMID:38584562 | DOI:10.2174/0113862073262227231005074024 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Hafiza Ayesha Nazir Nusrat Shafiq Simone Brogi Zill-I-Huma Nazli Jallat Khan Maryam Rashid Shagufta Parveen Source Type: research

Network Pharmacology and Experimental Verification of Si Shen Decoction Regulating FABP4/PPAR γ/NFκB Pathway in the Treatment of Collagen-induced Arthritis
CONCLUSION: SSD can relieve joint symptoms in CIA rats and alleviate inflammation by inhibiting the FABP4/PPARγ/NFκB signaling pathway. The effect of high-dose SSD was more prominent.PMID:38584563 | DOI:10.2174/0113862073296957240312090935 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Rui Guan Jiashu Yao Qing Qi Jing Yu Ruoshi Liu Mingli Gao Source Type: research

Role of Radiation-related Lung Function Genes in Prognosis and Immune Infiltration of Lung Adenocarcinoma
CONCLUSION: The prognosis-related genes identified in this paper and the risk model created can serve as a reference for diagnosing and treating LUAD.PMID:38584564 | DOI:10.2174/0113862073275640231228124547 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Fei Teng Xiaojing Sun Yuge Ran Chan Liu Hongyun Shi Yuan Tian Source Type: research

Technological Aspects of Nanoemulsions for Post-harvest Preservation of Fruits and Vegetables
In conclusion, this review offers insights into the promising prospects of using nanoemulsions in food preservation.PMID:38584565 | DOI:10.2174/0113862073297299240325084138 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: D Patel A Jha J Shah Source Type: research

Recent Advances in Catalytic Systems for the Reduction of Aromatic and Aliphatic Nitrile Compounds to Amines
Comb Chem High Throughput Screen. 2024 Apr 4. doi: 10.2174/0113862073284975240324091848. Online ahead of print.ABSTRACTAmines are important and valuable compounds widely used in the chemical industry to produce various products such as dyes, detergents, solvents, additives, pharmaceutical products, and anti-foam agents. A property that distinguishes primary amines from other compounds is their straightforward functionalization. Therefore, the synthesis of different amine compounds has been considered by many researchers in recent years. Usually, primary amines are produced via amination of alcohols, reductive amination, an...
Source: Combinatorial Chemistry and High Throughput Screening - April 8, 2024 Category: Chemistry Authors: Sara Ansari Shahab Shariati Source Type: research