Efficacy and safety of robot-assisted thoracic surgery (RATS) compare with video-assisted thoracoscopic surgery (VATS) for lung lobectomy in patients with non-small cell lung cancer.
CONCLUSIONS: RATS result in better mortality as compared with VATS. However, robotics seems to have longer operative time and higher hospital costs, without superior advantages in morbidity rates and oncologic efficiency. Since the advantages of RATS has been performed in some area, the continuation of a comparative investigation with VATS may be necessary. And some effort need to be taken into consideration to reduce the operative time and cost. PMID: 30973106 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 11, 2019 Category: Chemistry Authors: Hu X, Wang M Tags: Comb Chem High Throughput Screen Source Type: research

Contribution of Resveratrol in Development of Novel Urease Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies.
Abstract A new library of resveratrol derivatives was designed and synthesized in excellent yield via two step reaction utilizing Vilsmeier reaction as first step and subsequent addition of substituted aromatic amine in the second step. Newly synthesized compounds were found to possess better docking score (-5.941 to -6.894) and binding energy (-46.854 to -56.455) as compared to the parent resveratrol (-5.45 and -20.155) which revealed that newly synthesized compounds bind in a better way as compared to the parent molecule. Synthesized compounds were investigated for their antioxidant as well as for in vitro inhib...
Source: Combinatorial Chemistry and High Throughput Screening - April 10, 2019 Category: Chemistry Authors: Kataria R, Khatkar A Tags: Comb Chem High Throughput Screen Source Type: research

The key microRNAs regulated the development of non-small cell lung cancer by targeting TGF- β-induced epithelial-mesenchymal transition.
CONCLUSIONS: miRNA-330-3p and miRNA-205 were changed the most in the process of canceration in NSCLC. Furthermore, miR-330-3p promoted cell invasion and metastasis in NSCLC probably by promoting EMT and miR-205 could restrain NSCLC was likely by suppressing EMT. PMID: 30968775 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 10, 2019 Category: Chemistry Authors: Chen G, Ye B Tags: Comb Chem High Throughput Screen Source Type: research

MADD expression in lung adenocarcinoma and its impact on proliferation and apoptosis of lung adenocarcinoma cells.
CONCLUSION: MADD expression is significantly upregulated in lung adenocarcinoma tissue. MADD can promote lung adenocarcinoma cell growth by inhibiting apoptosis. This study may improve lung adenocarcinoma levels in patients and, thus, is worthy of clinical promotion. PMID: 30947659 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 4, 2019 Category: Chemistry Authors: Ye B, Zhong F, Yu G, Lou H, Hu J Tags: Comb Chem High Throughput Screen Source Type: research

Identification of genes associated with lung adenocarcinoma prognosis.
Abstract OBJECTIVE: Lung cancer is the most prevalent cancer in the world, and lung adenocarcinoma is the most common lung cancer subtype. Identification and determination of relevant prognostic markers are the key steps to personalized cancer management. METHOD: We collected the gene expression profiles from 265 tumor tissues of stage I patient from the Cancer Genome Atlas (TCGA) databases. Using Cox regression model, we evaluated the association between gene expression and the overall survival time of patients adjusting for gender and age at initial pathologic diagnosis. RESULTS: Age at initial patholo...
Source: Combinatorial Chemistry and High Throughput Screening - April 4, 2019 Category: Chemistry Authors: He ZH, Lv W, Wang LM, Wang YQ, Hu J Tags: Comb Chem High Throughput Screen Source Type: research

Statistical Modelling Outcome of In Vitro Fertilization and Intracytoplasmic Sperm Injection.
CONCLUSION: The fastest clinical pregancy declining age is ranged between 25 and 32, and female infertility type is evidenced as another key predictive factor for the cumulative outcome of ART. PMID: 30947663 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 4, 2019 Category: Chemistry Authors: Xu B, Liu C, Qian L, Qu Y, Su W, Xu J, Zhao J Tags: Comb Chem High Throughput Screen Source Type: research

Expression and significance of LncRNA-MINCR and CDK2 mRNA in primary hepatocellular carcinoma.
Abstract OBJECTIVE: To investigate the expression of long-chain non-coding RNA MINCR (LncRNA-MINCR) and cyclin-dependent kinase 2 (CDK2) mRNA in primary hepatocellular carcinoma, and to analyze the relationship between its expression and clinical pathological parameters and prognosis of hepatocellular carcinoma. METHODS: Seventy-five surgically resected primary hepatocellular carcinoma tissues and paracancerous tissues were selected. Real-time PCR was used to detect the expression of LncRNA-MINCR and CDK2 mRNA in hepatocellular carcinoma tissues and adjacent tissues. The relationship of clinicopathological pa...
Source: Combinatorial Chemistry and High Throughput Screening - April 4, 2019 Category: Chemistry Authors: Lian J, Zhang X, Lu Y, Hao S, Zhang Z, Yang Y Tags: Comb Chem High Throughput Screen Source Type: research

Misdiagnosis of Intrahepatic Biliary Cystadenoma Located in Caudate Lobe: A Case Report.
CONCLUSION: The experience and lessons of misdiagnosis in this case may help other clinicians diagnose the rare disease accurately. PMID: 30947661 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 2, 2019 Category: Chemistry Authors: Xu HJ, Zhu ZY, Yu JH, Wang W, Shen ZH Tags: Comb Chem High Throughput Screen Source Type: research

Expression and significance of Th17 cells and related factors in patients with autoimmune hepatitis.
CONCLUSION: Our finding demonstrates that Th17 cell frequency and their related factors IL-17 and TNF-α, are associated with liver damage, which might be used to monitor AIH disease severity. PMID: 30947662 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 2, 2019 Category: Chemistry Authors: An J Tags: Comb Chem High Throughput Screen Source Type: research

Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent Free Conditions.
CONCLUSION: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, an inexpensive and practicability procedure, and high efficiency. PMID: 30914018 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 25, 2019 Category: Chemistry Authors: Habibzadeh S, Ghasemnejad-Bosra H, Haghdadi M, Heydari-Parastar S Tags: Comb Chem High Throughput Screen Source Type: research

Can IL-33 and Endocan be New Markers for Retinopathy of Prematurity?
Abstract BACKGROUND: Retinopathy of prematurity (ROP) is a pathophysiologic condition of the retina due to abnormal proliferation of retinal vessels. OBJECTIVE: To ascertain the importance of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), interleukin-33 (IL-33) and endocan in the diagnosis and follow-up of ROP. METHOD: This prospective cohort study was conducted in the neonatal intensive care unit (NICU) of Health Science University, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey, between February 2017 and August 2018. Preterm infants (gestational age (GA)...
Source: Combinatorial Chemistry and High Throughput Screening - March 25, 2019 Category: Chemistry Authors: Cakir U, Tayman C, Yucel C, Ozdemir O Tags: Comb Chem High Throughput Screen Source Type: research

Progress in Molecularly Imprinted Polymers for Biomedical Applications.
CONCLUSION: We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future. PMID: 30914017 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 24, 2019 Category: Chemistry Authors: Choi JR, Yong KW, Choi JY, Cowie AC Tags: Comb Chem High Throughput Screen Source Type: research

Facile synthesis and cytotoxicity of phenazine-chromene hybrid molecules derived from phenazine natural product.
CONCLUSION: Compound 3c may be used as potential lead molecule against A549 cancer cells. PMID: 30848195 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 7, 2019 Category: Chemistry Authors: Zhang MC, Gu SH, Liu GP, Li CC, Xu HM, Wu ZX, Ye BP, Lu YY, Huang DC, Wang ZX, Jiang F Tags: Comb Chem High Throughput Screen Source Type: research

Green Fabrication of Cobalt NPs using Aqueous Extract of Antioxidant Rich Zingiber and Their Catalytic Applications for the Synthesis of Pyrano[2,3-c]pyrazoles.
CONCLUSION: The prepared pyrano[2,3-c]pyrazole derivatives were obtained in high yields within short reaction times and the nanocatalyst was easily separated using an external magnet and reused for several times with no significant loss of its activity. PMID: 30848196 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 7, 2019 Category: Chemistry Authors: Mianai RS, Ghasemzadeh MA, Monfared MRZ Tags: Comb Chem High Throughput Screen Source Type: research

Salivary antioxidant and oxidative stress marker levels in HIV-positive individuals.
CONCLUSION: The antioxidant defense system in HIV-positive individuals was low and oxidative stress was high in this population. Saliva might be used as a diagnostic tool for antioxidant changes in HIV-positive patients in future. There were changes in salivary antioxidant defense system and oxidative stress in HIV-positive individuals. Antioxidant supplements might help local salivary and general health statuses. PMID: 30843481 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 6, 2019 Category: Chemistry Authors: Amjad SV, Davoodi P, Goodarzi MT, Abdolsamadi H, Poorolajal J, Parsa S, Paydari D, Ahmadi-Motamayel F Tags: Comb Chem High Throughput Screen Source Type: research

Relationship between Prolidase Activity and Atrial Electromechanical Changes in Patients with Paroxysmal Atrial Fibrillation.
This study investigated the association between atrial conduction time and prolidase activity, a collagen synthesis enzyme, and P-wave dispersion (PWD) in patients with paroxysmal atrial fibrillation (PAF). METHODS: Exclusion criteria included age of
Source: Combinatorial Chemistry and High Throughput Screening - March 6, 2019 Category: Chemistry Authors: Tascanov MB Tags: Comb Chem High Throughput Screen Source Type: research

Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors.
CONCLUSION: ST-hPDE4B2 with much higher activity yield may be a favorable alternative target to characterize/screen rolipram analogues as hPDE4B inhibitors in high-throughput mode. PMID: 30843483 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 6, 2019 Category: Chemistry Authors: Zhang X, He S, Hu X, Wu J, Li X, Lia F, Yang X Tags: Comb Chem High Throughput Screen Source Type: research

Serum thiol - disulphide levels in epileptic pediatric patients.
CONCLUSION: We demonstrated a meaningful relationship between oxidative stress markers and epilepsy in pediatric patients. PMID: 30834829 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2019 Category: Chemistry Authors: Halil H, Tuygun N, Aksoy E, Erel O, Karacan CD Tags: Comb Chem High Throughput Screen Source Type: research

Ultrastructural analysis of human gallstones using synchrotron radiation μCT.
CONCLUSIONS: The ultrastructure of gallstones exhibits considerable diversity and complexity. The synchrotron radiation phase-contrast X-ray microtomography is a valuable tool for in-depth study of human gallstones. PMID: 30799788 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 22, 2019 Category: Chemistry Authors: Chen W, Liu R, Tao S, Shen W, Zhou W, Song C, Lu H, Xing C Tags: Comb Chem High Throughput Screen Source Type: research

Network Pharmacology and Reverse Molecular Docking-Based Prediction of the Molecular Targets and Pathways for Avicularin against Cancer.
CONCLUSION: The network pharmacology strategy used herein provided a powerful means for the mechanisms of action for bioactive ingredients. PMID: 30727880 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 6, 2019 Category: Chemistry Authors: Duan C, Li Y, Dong X, Xu W, Ma Y Tags: Comb Chem High Throughput Screen Source Type: research

The adverse events rate of endothelial progenitor cell capturing stent in CAD patients' treatment.
CONCLUSION: After one year follow-up, the incident of genous stent adverse events accident rate present stable in CAD patients. The study can be better for evaluation of genous stent, and it provides a better reference for CAD clinical treatment. PMID: 30698109 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 28, 2019 Category: Chemistry Authors: Xu WY, Tang WL, Yuan M, Sun Y, Xu F, Peng F Tags: Comb Chem High Throughput Screen Source Type: research

Constructing Prediction Model of Lung Cancer Recurrence Risk Using Gene Function Clustering and Machine Learning.
CONCLUSION: In this study, we discovered several genes related to lung cancer resistance and established a risk model to predict high-risk patients. PMID: 30698110 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 28, 2019 Category: Chemistry Authors: Zhong J, Chen JM, Chen SL, Yi YF Tags: Comb Chem High Throughput Screen Source Type: research

Computational method for the identification of molecular metabolites involved in cereal hull color variations.
CONCLUSIONS: A total of 158 key metabolites were found to be useful in distinguishing white cereal hulls from colorful cereal hulls. A prediction model constructed with these metabolites and a random forest algorithm generated a high Matthews coefficient correlation value of 0.701. Furthermore, 24 of these metabolites were previously found to be relevant to cereal color. Our study can provide new insights into the molecular basis of cereal hull color formation. PMID: 30698111 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 28, 2019 Category: Chemistry Authors: Zhang Y, Dong D, Li D, Lu L, Li J, Zhang Y, Chen L Tags: Comb Chem High Throughput Screen Source Type: research

The association of vitamin D receptor gene polymorphism with lung cancer risk: an update meta-analysis.
In conclusion, VDR genetic polymorphism may be correlated to lung cancer risk. Given limited number of the included studies, more observations are warranted to draw a safer conclusion. PMID: 30686249 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 25, 2019 Category: Chemistry Authors: Yu ZH, Chen M, Zhang QQ, Hu X Tags: Comb Chem High Throughput Screen Source Type: research

Using Na ïve Bayes algorithm to estimate the response to drug in lung cancer patients.
CONCLUSION: According to the different sensitivities of lung cancer patients to drug response, this study screened out genes that were significantly associated with drug resistance. The bayes model was used to assess patient resistance. PMID: 30686250 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 25, 2019 Category: Chemistry Authors: Guo B, Zheng Q Tags: Comb Chem High Throughput Screen Source Type: research

Efficacy and safety of addition of anti-PD1 to chemotherapy in treatment of non-small cell lung cancer.
Abstract BACKGROUND: Patients with previously treated non-small-cell lung cancer (NSCLC) have limited treatment options. A novel treatment based on programed death 1 (PD-1)/programed death ligand 1 (PD-L1) inhibitors has emerged as promising therapeutic options for advanced NSCLC. We assessed oncological outcomes of PD-L1 antibody versus docetaxel in previously treated NSCLC. OBJECTIVES: The purpose of this meta-analysis was to analysis the oncological outcomes of anti-PD1 to chemotherapy in treatment of non-small-cell lung cancer. RESULTS: Overall survival (OR=0.68,95%CI=0.61-0.75, P
Source: Combinatorial Chemistry and High Throughput Screening - January 25, 2019 Category: Chemistry Authors: Ru CH, Zhuang YB Tags: Comb Chem High Throughput Screen Source Type: research

A Case Analysis on CT Guided Percutaneous Lung Puncture Biopsy of Lymphocyte Mesenchymal Pneumonia.
CONCLUSION: The diagnosis of lymphocyte interstitial pneumonia (LIP) with high-resolution CT may be used to increase its clinical diagnosis rate, reduce misdiagnosis and improve early detection. PMID: 30666907 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 21, 2019 Category: Chemistry Authors: Zhu D, Yu L, Chen H Tags: Comb Chem High Throughput Screen Source Type: research

Integrative analysis of dysfunctional modules driven by genomic alterations at system level across 11 cancer types.
CONCLUSION: Taken together, our study sheds light on both cancer-specific and cross-cancer characteristics systematically. PMID: 30666908 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 21, 2019 Category: Chemistry Authors: Wang Y, Liu Z, Lian B, Liu L, Xie L Tags: Comb Chem High Throughput Screen Source Type: research

Efficacy and toxicity of addition of bevacizumab to chemotherapy in patients with metastatic colorectal cancer.
Abstract BACKGROUND: Pre-treated patients with first-line treatment can be offered a second treatment with the aim of improving their poor clinicalprognosis. The therapy of metastatic colorectal cancer (CRC) patients who did not respond to first-line therapy has limited treatment options. Recently, many studies have paid much attention on the efficacy of bevacizumab as adjuvant treatment for metastatic colorectal cancer. OBJECTIVES: We aim to evaluate the efficacy and toxicity of bevacizumab plus chemotherapy compared with bevacizumab-naive based chemotherapy as second-line treatment in people with metastatic...
Source: Combinatorial Chemistry and High Throughput Screening - January 19, 2019 Category: Chemistry Authors: Ruan WC, Che YP, Ding L, Li HF Tags: Comb Chem High Throughput Screen Source Type: research

Serum α-1 acid glycoprotein 1 is a biomarker for the prediction of targeted therapy resistance in advanced EGFR-positive lung adenocarcinoma.
CONCLUSIONS: Serum ORM1 has an important diagnostic value for the diagnosis of EGFR-positive LUAD and EGFR-TKI resistance in patients especially with advanced EGFR-positive LUAD. Our findings suggest that serum ORM1 is a biomarker in the prediction of EGFR-TKI resistance in EGFR-positive LUAD. PMID: 30663564 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 19, 2019 Category: Chemistry Authors: Xu YF, Xu Y, Li X, Yang XM Tags: Comb Chem High Throughput Screen Source Type: research

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children.
Abstract Aim To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Infection with M. pneumoniae was confirmed by ELISA for M. pneumoniae antibody, PCR, and throat culture. Antibiotic resistance was measured from the minimum inhibitory concentrations (MICs) of antibiotics. Th...
Source: Combinatorial Chemistry and High Throughput Screening - January 10, 2019 Category: Chemistry Authors: Chen Yuan CX, Min FM, Ling YJ, Li G, Ye HZ, Pan JH, Wang L, Xie YP Tags: Comb Chem High Throughput Screen Source Type: research

An invasive hemolymphangioma of the pancreas in a young woman.
CONCLUSION: From our case and literature, we can conclude that hemolymphangioma of the pancreas is uncommon benign tumor, and it is hard to make an accurate diagnosis preoperatively. Radical surgical resection should be performed whenever possible. The prognosis of this disease seems good. PMID: 30605051 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 2, 2019 Category: Chemistry Authors: Zhang Z, Ke Q, Xia W, Zhang X, Shen Y, Zheng S Tags: Comb Chem High Throughput Screen Source Type: research

Maxillary metastasis of esophageal cancer: report of the first case and literature review.
CONCLUSION: ECMM may belongs to the hematogenous metastasis. The early detection of rare sites of metastasis of EC should be prioritized in tumor marker detection, imaging, pathology, and other diagnostic techniques. PMID: 30605052 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 2, 2019 Category: Chemistry Authors: Hu H, Wang J, Zhou XY, Tong MT, Zhai CY, Sui XB, Zhang YH, Xie XX, Liu H, Xie JS, Pan HM, Li D Tags: Comb Chem High Throughput Screen Source Type: research

Multiple-line Chemotherapy and Tyrosine Kinase Inhibitor Treatment in Patients with Advanced Lung Cancer.
CONCLUSION: The present study demonstrated the benefits of TKI in patients with advanced lung cancer, providing insights into the refinement of the management strategy. PMID: 30599105 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 31, 2018 Category: Chemistry Authors: Zhang H, Yang J, Deng YM, Zhao N, Liang JM, Yang S, Zhang SD, Feng WN Tags: Comb Chem High Throughput Screen Source Type: research

Analysis of four types of leukemia using Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment scores.
CONCLUSION: This analysis may provide a useful tool for the discrepant pathogenesis and drug design of different types of leukemia. PMID: 30599106 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 31, 2018 Category: Chemistry Authors: Lu J, Zhang YH, Wang S, Bi Y, Huang T, Luo X, Cai YD Tags: Comb Chem High Throughput Screen Source Type: research

Computational method for identifying malonylation sites by using random forest algorithm.
CONCLUSION: Results showed that certain types of PSSM and disorder features may be closely associated with malonylation of lysine residues. Our study contributes to development of computational approaches for predicting malonyllysine and provides insights into molecular mechanism of malonylation. PMID: 30588879 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 27, 2018 Category: Chemistry Authors: Wang S, Li J, Sun X, Zhang YH, Huang T, Cai Y Tags: Comb Chem High Throughput Screen Source Type: research

Loop Transverse Colostomy - A Modified Technique.
CONCLUSION: In comparison with conventional methods, the modified transverse colostomy is a safe and effective diverting technique. It can be readily performed by all kinds of surgeons, especially those in underdeveloped areas. The technique represents a preferred method for constructing temporary stoma in rectal cancer patients treated with neoadjuvant chemoradiotherapy. PMID: 30582474 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 21, 2018 Category: Chemistry Authors: Cai C, Dai Z, Zhong Z, Wang J, Du J Tags: Comb Chem High Throughput Screen Source Type: research

A Novel, Fast and Efficient One-Pot Three-Component Procedure for the Preparation of New Imidazolidinone Derivatives from Isocyanide, Aldehyde and Urea.
Abstract The synthesis of imidazolidinone derivatives has been described through the intermolecular cycloaddition of imine and isocyanides. The procedure is simple, straightforward and without any by product. PMID: 30569851 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 20, 2018 Category: Chemistry Authors: Safaei H, Firoozi N, Zebarjadian M, Jehbez SA, Safaei M Tags: Comb Chem High Throughput Screen Source Type: research

An Integrated Feature Selection Algorithm for Cancer Classification using Gene Expression Data.
CONCLUSION: Our proposed CFS-MOEA algorithm attained up to 100% classification accuracy for six out of eleven datasets with a minimal sized predictive gene subset. PMID: 30569852 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 20, 2018 Category: Chemistry Authors: Ahmed S, Kabir M, Ali Z, Arif M, Ali F, Yu DJ Tags: Comb Chem High Throughput Screen Source Type: research

In Silico Prediction of Inhibitory Constant of Thrombin Inhibitors Using Machine Learning.
This study was carried out to predict Ki values of thrombin inhibitors based on a large data set by using machine learning methods. Taking advantage of finding non-intuitive regularities on high-dimensional datasets, machine learning can be used to build effective predictive models. A total of 6554 descriptors for each compound were collected and an efficient descriptor selection method was chosen to find the appropriate descriptors. Four different methods including multiple linear regression (MLR), K nearest neighbors (KNN), gradient boosting regression tree (GBRT) and support vector machine (SVM) were implemented to buil...
Source: Combinatorial Chemistry and High Throughput Screening - December 20, 2018 Category: Chemistry Authors: Zhao J, Zhu L, Zhou W, Yin L, Wang Y, Fan Y, Chen Y, Liu H Tags: Comb Chem High Throughput Screen Source Type: research

Prognostic impact of lymphadenectomy in different stages of malignant germ cell tumor of the ovary based on propensity score matching.
CONCLUSION: Lymphadenectomy significantly increased the survival probability of OGCT patients in stage III and IV, but had no significant influence on early stage patients (stage I and II), indicating lymphadenectomy should be performed in a stage-dependent manner in clinical utility. PMID: 30569854 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 20, 2018 Category: Chemistry Authors: Chen Y, Ning Y, Zhang Q, Xie Y Tags: Comb Chem High Throughput Screen Source Type: research

An Approach of Anomaly Detection and Neural Network Classifiers to Measure Cellulolytic Activity.
CONCLUSION: We assume that our approach can be a viable alternative for high throughput screening of enzymatic activity in real time. PMID: 30569862 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 19, 2018 Category: Chemistry Authors: Barbosa-Santillán LF, de Los Angeles Calixto-Romo M, Sánchez-Escobar JJ, Barbosa-Santillán LI Tags: Comb Chem High Throughput Screen Source Type: research

Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals.
Abstract The transformation of low cost sugar feedstocks into market chemicals and monomers for existing or novel high performance polymers by chemical catalysis is reviewed. Emphasis is given to industrially relevant, continuous flow, trickle bed processes. Since long term catalyst stability under hydrothermal conditions is an important issue to be addressed in liquid phase catalysis using carbohydrate feedstocks, we will primarily discuss results of catalytic performance for prolonged times on stream. In particular, the selective aerobic oxidation of glucose to glucaric acid and the subsequent selective hydrogen...
Source: Combinatorial Chemistry and High Throughput Screening - December 19, 2018 Category: Chemistry Authors: Diamond G, Hagemeyer A, Murphy V, Sokolovskii V Tags: Comb Chem High Throughput Screen Source Type: research

Supervised Machine Learning Algorithms for Evaluation of Solid Lipid Nanoparticles and particle size.
CONCLUSIONS: Our findings present that machine learning methods can be highly useful for determining formulation parameters for further research. PMID: 30569864 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 18, 2018 Category: Chemistry Authors: Öztürk AA, Gündüz AB, Ozisik O Tags: Comb Chem High Throughput Screen Source Type: research

A network integration method for deciphering the types of metabolic pathway of chemicals with heterogeneous information.
CONCLUSION: Each binary model gave a quite good performance and was superior to the classic prediction model, indicating that the proposed models can be useful tools for integrating heterogeneous information to assign chemicals into correct metabolic pathways. PMID: 30520371 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 5, 2018 Category: Chemistry Authors: Guo ZH, Chen L, Zhao X Tags: Comb Chem High Throughput Screen Source Type: research

Synthesis of novel α-amidino carboxylic acids and their use as H-Bond Catalysts in Strecker reaction.
CONCLUSION: A simple and efficient method for synthesis of ɑ-amidino carboxylic acids was developed in this research. These compounds have been used as a single H-bond donor catalyst in the Strecker reaction. DFT calculations were carried out to confirm the experimental results. The obtained data from computations are in good agreement with experimental results. PMID: 30426895 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 13, 2018 Category: Chemistry Authors: Zaghari Z, Azizian J Tags: Comb Chem High Throughput Screen Source Type: research

Preparation and characterization of a novel room temperature dicationic ionic liquid and its application in the synthesis of xanthenediones under solvent-free conditions.
Abstract A novel room temperature dicationic ionic liquid, namely 1, 1'-sulfinyldiethylammonium bis (hydrogen sulfate), was prepared and characterized by 1H NMR, 13C NMR, and FT-IR as well as Hammett acidity function and used as a powerful and recyclable catalyst for the synthesis of xanthenediones with high to excellent yields as well as short reaction times under solvent-free conditions. PMID: 30398113 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 5, 2018 Category: Chemistry Authors: Ehsani-Nasab Z, Ezabadi A Tags: Comb Chem High Throughput Screen Source Type: research

Predicting Inhibitors for Multidrug Resistance Associated Protein-2 Transporter by Machine Learning Approach.
CONCLUSION: It was observed that support vector machine model built on features selected using recursive feature elimination method is showing the best performance. The developed model can be used in the early stages of drug discovery for identifying the inhibitors of multidrug resistance associated protein-2 efflux transporter. PMID: 30360705 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 23, 2018 Category: Chemistry Authors: Kharangarh S, Sandhu H, Tangadpalliwar S, Garg P Tags: Comb Chem High Throughput Screen Source Type: research

Synthesis of functionalized magnetite titanium dioxide nanocomposite for removal of Acid Fuchsine dye.
Abstract In this research, a novel magnetite titanium dioxide nanomesopore functionalized by amine groups (Fe3O4@SiO2@TiO2-NH2) was synthesized and its potential for efficient removal of Acid fuchsine (AF) as an anionic dye from aqueous solutions was investigated. For this aim, the core-shell structure of Fe3O4@SiO2@TiO2 was prepared using Fe3O4 as magnetic core, tetra ethyl orthosilicate as silica and tetra butyl titanate as titanium sources for shell. The synthesized nanomesopores (particle size lower than 44 nm) were characterized by FT-IR, XRD, DRS, SEM and TGA instruments. The various experimental parameters ...
Source: Combinatorial Chemistry and High Throughput Screening - October 19, 2018 Category: Chemistry Authors: Rahnama S, Shariati S, Divsar F Tags: Comb Chem High Throughput Screen Source Type: research

Inexpensive Weight-Reducing Aid (L-Carnitine) as An Efficient Catalyst for Synthesis of Benzimidazoles.
CONCLUSION: A facile synthesis of benzimidazoles comprising the reaction of various aldehydes with substituted o-phenylendiamine in good to excellent yield is provided using L-Carnitine as an efficient catalyst. The protocol overcomes the earlier disadvantages like harsh reaction conditions, tedious work-up, expensive process, wastes generation and the use of metallic oxide, which might be applied to synthesis of benzimidazoles pharmaceticals in order to meet friendly environmental demands. PMID: 30338731 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 18, 2018 Category: Chemistry Authors: Zhang M, Huang G, Zhang X, Lin Z, Li Y, Li B, Chen L Tags: Comb Chem High Throughput Screen Source Type: research