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Gold Nanoparticle-based Biosensors for Point-of-Care Diagnostics: A Review of Sensing Nanoparticle Applications and Future Prospects
Comb Chem High Throughput Screen. 2024 Mar 27. doi: 10.2174/0113862073293557240320065128. Online ahead of print.ABSTRACTPoint of Care Diagnostics (POCD) is quintessential in hospitals and the healthcare sector as the secants uplift the quality of medical care and the life of a patient by facilitating quick identification of the underlying pathological condition. Nanotechnology can provide opportunities and has potential in the development of new-age sensing/diagnostic tools. Owing to extraordinary features (e.g., higher density, effective catalysis, good conduction, biocompatibility, inertness, and greater surface-to-volum...
Source: Combinatorial Chemistry and High Throughput Screening - March 29, 2024 Category: Chemistry Authors: Sakshi Chauhan Roopal Mittal Manish Kumar Amit Mittal Ajay Singh Kushwah Source Type: research

Effect of Benzodiazepines and Z-Drug Medications during Antenatal and Postnatal Depression and Anxiety: A Systematic Review and Meta-Analysis
CONCLUSION: Although BZDs and Z-drugs are effective in managing insomnia during peripartum and post-partum, they are either ineffective or contraindicated for managing anxiety and depression in pregnant women compared to anxiolytics and anti-depressants.PMID:38551056 | DOI:10.2174/0113862073278815240325045209 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 29, 2024 Category: Chemistry Authors: Di Xin Yan Wang Guangping Hua Tuo Liu Source Type: research

A Serum Pharmacochemistry and Network Pharmacology-based Approach to Study the Anti-depressant Effect of Chaihu-Shugan San
CONCLUSION: This study not only provides a theoretical basis for further expanding the clinical application of CHSGS, but also provides a series of potential lead compounds for the development of depression drugs.PMID:38551057 | DOI:10.2174/0113862073285198240322072301 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 29, 2024 Category: Chemistry Authors: Man-Fei Deng Yi-Zhi Yan Shan-Shan Zhu Ke Zhou Si-Jie Tan Peng Zeng Source Type: research

Ras-related Protein in Brain 4A (Rab4A) is Downregulated by miR-496 to inhibit the Progression of Gastric Cancer
CONCLUSION: In conclusion, the expression of Rab4A is inhibited by miR-496, and the knockdown of Rab4A inhibits the proliferation, migration and invasion through down-regulating the surface expression of EGFR. Rab4A is a potential target in the treatment of gastric cancer.PMID:38523522 | DOI:10.2174/0113862073260841231010055245 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 25, 2024 Category: Chemistry Authors: Rui Su Meng Su Yan Lu Source Type: research

Advances in MiRNAs Involved in Endometrial Carcinoma
Comb Chem High Throughput Screen. 2024 Mar 19. doi: 10.2174/0113862073299444240308145725. Online ahead of print.ABSTRACTEndometrial carcinoma (EC) is a common malignancy worldwide. Existing evidence has revealed that EC could be associated with abnormal gene expression. Meantime, evidence supports that miRNAs act as critical regulators in gene expression through the binding to the 3'- untranslated region (3'-UTR). Accordingly, this review concludes some recent studies focusing on miRNAs that influence EC, aiming at understanding the association between miRNAs and EC more clearly and providing a reference for further studie...
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Yan He Ke Liao Hua Peng Xiangman Zou Zifen Guo Source Type: research

Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation Development
Comb Chem High Throughput Screen. 2024 Mar 19. doi: 10.2174/0113862073285654240308055228. Online ahead of print.ABSTRACTOrganic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of poorly soluble drugs can be increased by dissolving them in a concentrated solution comprising various substances. Methods commonly used to improve solubility include complexation, pH modifica...
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Pranjal Kumar Singh Nidhi Singh Atul Pratap Singh Poonam Bhardwaj Kapil Sachan Smita Singh Source Type: research

The Role of Emodin in the Treatment of Bladder Cancer based on Network Pharmacology and Experimental Verification
CONCLUSION: This study integrates network pharmacology with in vitro experimentation to elucidate the potential mechanisms underlying the action of Emodin against BLCA. The results of this research enhance our understanding of the pharmacological mechanisms by which Emodin may be employed in treating BLCA.PMID:38504574 | DOI:10.2174/0113862073294990240122140121 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Fule Liu Jianghao Li Boruo Zhou Yang Shen Jingyuan Tang Jie Han Changpeng Chen Kang Shao Haojie Chen Lin Yuan Source Type: research