Combinatorial Chemistry and High Throughput Screening This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Advances in MiRNAs Involved in Endometrial Carcinoma
Comb Chem High Throughput Screen. 2024 Mar 19. doi: 10.2174/0113862073299444240308145725. Online ahead of print.ABSTRACTEndometrial carcinoma (EC) is a common malignancy worldwide. Existing evidence has revealed that EC could be associated with abnormal gene expression. Meantime, evidence supports that miRNAs act as critical regulators in gene expression through the binding to the 3'- untranslated region (3'-UTR). Accordingly, this review concludes some recent studies focusing on miRNAs that influence EC, aiming at understanding the association between miRNAs and EC more clearly and providing a reference for further studie...
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Yan He Ke Liao Hua Peng Xiangman Zou Zifen Guo Source Type: research

Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation Development
Comb Chem High Throughput Screen. 2024 Mar 19. doi: 10.2174/0113862073285654240308055228. Online ahead of print.ABSTRACTOrganic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of poorly soluble drugs can be increased by dissolving them in a concentrated solution comprising various substances. Methods commonly used to improve solubility include complexation, pH modifica...
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Pranjal Kumar Singh Nidhi Singh Atul Pratap Singh Poonam Bhardwaj Kapil Sachan Smita Singh Source Type: research

The Role of Emodin in the Treatment of Bladder Cancer based on Network Pharmacology and Experimental Verification
CONCLUSION: This study integrates network pharmacology with in vitro experimentation to elucidate the potential mechanisms underlying the action of Emodin against BLCA. The results of this research enhance our understanding of the pharmacological mechanisms by which Emodin may be employed in treating BLCA.PMID:38504574 | DOI:10.2174/0113862073294990240122140121 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 20, 2024 Category: Chemistry Authors: Fule Liu Jianghao Li Boruo Zhou Yang Shen Jingyuan Tang Jie Han Changpeng Chen Kang Shao Haojie Chen Lin Yuan Source Type: research

Gegen Qinlian Decoction Modulates Atherosclerosis and Lipid Metabolism Through Cellular Interplay and Signaling Pathways
CONCLUSION: GQD improves rat atherosclerosis and hepatic lipid metabolism by regulating PPAR-γ, LXR-α, LXR-β, ABCA1, ABCA7, and ABCG1 expression and augmenting cellular intercalation through the GAS6/TAM pathway.PMID:38486386 | DOI:10.2174/0113862073285562240305113728 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 15, 2024 Category: Chemistry Authors: Zhiwei Zhang Yu Zhou Qin Lv Kun Gao Zhiguo Li Qing Miao Li Shen Source Type: research

FTO in Lung Cancer: Its Progression and Therapeutic Potential
Comb Chem High Throughput Screen. 2024 Mar 12. doi: 10.2174/0113862073281598240227072839. Online ahead of print.ABSTRACTOne of the most fatal and frequent malignancies on the planet is lung cancer. Its occurrence and development are the results of multifactorial and multigenic interactions. In recent years, RNA N6-methyladenosine transferase (FTO) has gained significant attention in the field of oncology. FTO is the first RNA demethylase to be found to control target mRNA demethylation. The growth, proliferation, and metastasis of tumor cells are greatly influenced by FTO. Recent studies have found that imbalanced m6A meth...
Source: Combinatorial Chemistry and High Throughput Screening - March 14, 2024 Category: Chemistry Authors: Xue-Fen Chen Chen Gong Source Type: research

DPP2/7 is a Potential Predictor of Prognosis and Target in Immunotherapy in Colorectal Cancer: An Integrative Multi-omics Analysis
CONCLUSION: DPP7 could serve as a CRC prognosis marker, functioning as an oncogene and representing a potential immunotherapeutic target.PMID:38454764 | DOI:10.2174/0113862073290831240229060932 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 8, 2024 Category: Chemistry Authors: Zhihao Shang Yueyang Lai Haibo Cheng Source Type: research

Daptomycin Inhibits Multiple Myeloma Progression through Downregulating the Expression of RPS19
CONCLUSION: DAP inhibited the proliferation, migration, and invasion and promoted the apoptosis of MM cells. Mechanistically, the RPS19 expression was significantly decreased in DAPtreated cells. This research provides a potential therapeutic drug for MM therapy.PMID:38454765 | DOI:10.2174/0113862073283460240129104114 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 8, 2024 Category: Chemistry Authors: Yijun Zhuang Yin Zhang Caiyun Chen Jincheng Chen Qiuxia Xu Peihong Wang Source Type: research