Combinatorial Chemistry and High Throughput Screening This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Investigating High-risk Factors, Precise Diagnosis, and Treatment of Castration-Resistant Prostate Cancer (CRPC)
CONCLUSION: Patients with prostate cancer diagnosed with distant metastasis at initial presentation require early intervention. Close monitoring of PSA and serum testosterone changes is necessary during the process of endocrine therapy. After entering the CRPC stage, the etiological classification precision treatment can improve the therapeutic effect and improve the prognosis of patients.PMID:37990901 | DOI:10.2174/0113862073266959231114052928 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 22, 2023 Category: Chemistry Authors: Yuan Ma Zihao Liu Wenyue Yu Hua Huang Yong Wang Yuanjie Niu Source Type: research

Based on Bioinformatics to Explore the Mechanism of "Tangzhiqing" Decoction Alleviating Type 2 Diabetes-associated Cognitive Dysfunction in Mice by Regulating Hippocampal Neuron Apoptosis and Autophagy
CONCLUSION: TZQ demonstrated a substantial reduction in neuronal apoptosis within the hippocampus and effectively suppressed excessive autophagy.PMID:37990900 | DOI:10.2174/0113862073255849231030114405 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 22, 2023 Category: Chemistry Authors: Yinli Shi Pei Sheng Yun Zhao Xu Wang Xiru Xu Sifan Sun Source Type: research

Andrographolide Attenuates RSV-induced Inflammation by Suppressing Apoptosis and Promoting Pyroptosis after Respiratory Syncytial Virus Infection In Vitro
CONCLUSION: These results suggest that andrographolide may reduce RSV-induced inflammation by suppressing apoptosis and promoting pyroptosis in epithelial cells, leading to effective viral clearance.PMID:37957849 | DOI:10.2174/0113862073256465231024075452 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Siyi Che Xiaohong Xie Jilei Lin Ying Liu Jun Xie Enmei Liu Source Type: research

Exploring Effects and Mechanism of Ingredients of Herba Epimedii on Osteogenesis and Osteoclastogenesis In Vitro
CONCLUSION: Neochlorogenic acid, Sagittatoside B, Chlorogenic acid, and Cryptochlorogenic acid promoted MC3T3-E1 differentiation, among which Neochlorogenic acid showed significant promotion in viability, mineralization, and OPN expression. Baohuoside 1, Sagittatoside B, Cryptochlorogenic acid, Neochlorogenic acid, Chlorogenic acid, and Icariin inhibited RAW264.7 differentiation, among which Baohuoside 1 showed significant inhibition on TRACP, multinucleated osteoclastic cells number and MPP-9 expression. The mechanism might relate to the FoxO signaling pathway, MAPK signaling pathway, and TNF signaling pathway.PMID:379578...
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Lei Song Yating Zhou Lin Qu Dongyu Wang Xinyue Diao Xiaoying Zhang Yuxia Zhai Yue Zhang Ying-Li Yu Kun Zhou Source Type: research

Exploring Novel Genome Instability-associated lncRNAs and their Potential Function in Pan-Renal Cell Carcinoma
CONCLUSIONS: In this study, we discovered four novel GI-lncRNAs and developed a novel signature that effectively predicted clinical outcomes in pan-RCC. The findings provide valuable insights for pan-RCC immunotherapy and shed light on potential underlying mechanisms.PMID:37957851 | DOI:10.2174/0113862073258779231020052115 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Hui-Xin Zhu Wen-Cai Zheng Hang Chen Jia-Yin Chen Fei Lin Shao-Hao Chen Xue-Yi Xue Qing-Shui Zheng Min Liang Ning Xu Dong-Ning Chen Xiong-Lin Sun Source Type: research

Investigation of Ginseng-Ophiopogon Injection on Enhancing Physical Function by Pharmacogenomics and Metabolomics Evaluation
CONCLUSIONS: This study provided an integrative and efficient approach to understanding the molecular mechanism of GOI in enhancing physical function.PMID:37957852 | DOI:10.2174/0113862073244102231020050502 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Chen Meimei Zhu Jingru Gan Huijuan Li Candong Source Type: research

Shikonin Suppresses Cell Tumorigenesis in Gastric Cancer Associated with the Inhibition of c-Myc and Yap-1
CONCLUSION: This study showed protooncogenes c-Myc and Yap-1 to be the core target genes of shikonin on gastric cancer cells. Shikonin may suppress gastric cancer cells by inhibiting the protooncogenes c-Myc and Yap-1. This suggests that shikonin may be a good candidate for the treatment of gastric cancer.PMID:37957853 | DOI:10.2174/0113862073254088231020082912 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Fei Zhang Mingliang Chu Jiemin Liu Qi Zhao Yanqiu Zhu Xuefang Wu Source Type: research

Testosterone with Silymarin Improves Diabetes-obesity Comorbidity Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene Expressions in Rats
CONCLUSION: These results concluded that TNSN exerted protective efficacy against the liver abnormalities in the co-morbidity of the DMOB rat model.PMID:37957854 | DOI:10.2174/0113862073272401231108054024 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Dongli Zhu Yuanyuan Du Lili Zhou Tahani Awad Alahmadi Samer Hasan Hussein-Al-Ali Qinhu Wang Source Type: research

Zang Siwei Qingfei Mixture Alleviates Inflammatory Response to Attenuate Acute Lung Injury by the ACE2/NF- κB Signaling Pathway in Mice
CONCLUSION: Zang Siwei Qingfei mixture attenuates ALI by regulating the ACE2/NF-κB signaling pathway in mice. This study provides a theoretical foundation for the development of improved ALI treatments.PMID:37957855 | DOI:10.2174/0113862073259884231024111447 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Si Lei Shangjie Wu Source Type: research

Pan-cancer Analysis Combined with Experiments Deciphers PHB Regulation for Breast Cancer Cell Survival and Predicts Biomarker Function
CONCLUSION: Although prohibitin is over-expressed in various cancer types, it functions as an important tumor suppressor that may suppress breast cancer cell proliferation and the invasive ability of MCF-7 by influencing its DNA synthesis and promoting cell apoptosis. All these may be likely associated with P53, erbB-2, and Bcl-2.PMID:37957856 | DOI:10.2174/0113862073266248231024113533 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Xiao-Yan Zhou Yue Li Jiali Liu Wei Lu Qian He Jing Li Sanyuan Liu Source Type: research

Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2
CONCLUSION: Focusing on the protective effects of CUR and ECs on cardiomyocytes is of great significance for the treatment of clinical myocardial HR injury.PMID:37957857 | DOI:10.2174/0113862073239166231103102648 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Jian-Kun Cui Mingming Fan Qinwen Wang Source Type: research

Efficacy and Safety of Acupuncture in the Treatment of Radicular Cervical Spondylosis: A Systematic Review and Meta-Analysis
CONCLUSION: Acupuncture is significantly more effective than traction therapy in the treatment of cervical spondylosis and can reduce the pain index of patients with CSR.PMID:37957858 | DOI:10.2174/0113862073265007231108050338 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2023 Category: Chemistry Authors: Hongfei Zhao Congan Wang Xuan Wang Jing Ju Chunchun Yan Bin Shi Source Type: research