Combinatorial Chemistry and High Throughput Screening This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development and Validation of Anoiki-Related Lncrna Signature Prediction Model for KIRC Prognosis
CONCLUSION: This study suggests that anoikis-related lncRNAs could serve as valuable prognostic markers for KIRC. Additionally, they may provide insight into future KIRC treatment options by reflecting on the situation of the kidney immune microenvironment.PMID:38305400 | DOI:10.2174/0113862073271880231114100544 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Yao Su Jin Yang Source Type: research

The Different Therapeutic Effects of Traditional Chinese Medicine Shensong Yangxin Capsule and Salubrinal in High-intensity Exercise-induced Heart Failure in Rats with Acute Myocardial Infarction
Conclusion: In rats with acute myocardial infarction in high-intensity exercise-induced heart failure, Shensong Yangxin Capsule dramatically reduces myocardial cell death and cardiac dysfunction. SSYX has a shorter course of treatment and a better therapeutic effect than Sal.PMID:38305401 | DOI:10.2174/0113862073272407231201071629 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Junli Lu Yanzhuo Ma Hongzhi Lv Congxin Li Leisheng Ru Jian Zhao Dongmei Wang Source Type: research

Research Progress in Single-herb Chinese Medicine and Compound Medicine for Knee Osteoarthritis
Comb Chem High Throughput Screen. 2024 Jan 4. doi: 10.2174/0113862073264850231116055745. Online ahead of print.ABSTRACTDue to an increase in the aging population, osteoarthritis (OA), especially knee osteoarthritis (KOA), has increasingly become one of the diseases affecting the quality of life of the elderly. As the pathogenesis of KOA is still unclear, Western medicine treatment lacks specificity, and surgical treatment is difficult to cover all patients. Therefore, in recent years, traditional Chinese medicine (TCM) for the conservative treatment of KOA has received increasing attention. The advantages of TCM are clearï...
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Guanghui Zhou Xianquan Zhang Zhuoxu Gu Jinlong Zhao Minghui Luo Source Type: research

Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for Determination of Bisoprolol in Clinical Samples
CONCLUSION: The presence of Cu metal due to galvanic displacement increased the sensitivity. These findings suggest that the new nanocatalyst has potential applications in sensors and electronics.PMID:38305403 | DOI:10.2174/0113862073270729231106090749 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Mohammad Reza Salemi Shahla Fathi Fereshteh Chekin Banafsheh Norouzi Source Type: research

Design, Virtual Screening, Molecular Docking, ADME and Cytotoxicity Studies of 1,3,5-Triazine Containing Heterocyclic Scaffolds as Selective BRAF Monomeric, Homo and Heterodimeric Inhibitors
CONCLUSION: It was identified that top-hit molecules had better binding and interaction activity than standard in all three classes of mutants.PMID:38305404 | DOI:10.2174/0113862073273813231113071010 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Ankit Kumar Singh P Sreelakshmi Prateek Pathak Adarsh Kumar Harshwardhan Singh Jagat Pal Yadav Amita Verma Maria Grishina Pradeep Kumar Source Type: research

Exploring the Potential Role of Massa Medicata Fermentata in Alcoholic Liver Injury Disease Based on Network Pharmacology and Animal Experiments
CONCLUSION: This study serves as a rationale to support MMF in the treatment of ALD and meets the urgent need for clinical treatment of ALD. At the same time, it broadens the scope of clinical application of MMF.PMID:38299285 | DOI:10.2174/0113862073278353231226100219 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Lu Yang Yuchen Bao Qinwen Fu Yue Fu Qingqing Tian Yu Tang Zihan Xia Huifang Zhou Chuyue Wu Jilin Sun Qinwan Huang Source Type: research

Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Cordycepin against Pulmonary Arterial Hypertension in Rats
CONCLUSION: This study identified that TP53, AKT1, CASP3, BAX, and BCL2L1 were the potential targets of Cordycepin against PAH by ameliorating pulmonary vascular remodeling, inhibiting the abnormal proliferation and migration of PASMCs and increasing apoptosis of PASMCs. which provided a new understanding of the pharmacological mechanisms of Cordycepin in the treatment of PAH.PMID:38299286 | DOI:10.2174/0113862073267432230925112002 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Jiangpeng Lin Yuzhuo Zhang Shuangfeng Lin Haiming Ding Weihua Liu Source Type: research

Understanding the Molecular Mechanisms of H2's Regulatory Effect on miR-29s for Brain Protection during Deep Hypothermic Circulatory Arrest
CONCLUSION: Based on the above facts, the brain protection mechanism of hydrogen in DHCAtreated rats may be related to the upregulation of miR-29s, which can exert its beneficial effects by alleviating apoptosis, inflammation, and oxidation.PMID:38299287 | DOI:10.2174/0113862073281209231227044205 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Hongmei Li Li Shen Junwen Ge Hongyun Li Feng Chen Xiaolong Chen Haifa Hong Source Type: research

Inhibition of Taurine-upregulated Gene 1 Upregulates MiR-34a-5p to Protect against Myocardial Ischemia/Reperfusion via Autophagy Regulation
CONCLUSION: These findings indicated that inhibiting TUG1 may reduce the extent of myocardial I/R injury by regulating miR-34a-5p. Taken together, these results suggest that LncRNA TUG1 may represent a novel therapeutic target for myocardial I/R injury.PMID:38299288 | DOI:10.2174/0113862073267559231106074309 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Qunjun Duan Aiqiang Dong Haifeng Cheng Shufen Zhang Wei Chen Weijun Yang Source Type: research

Network Pharmacology and Experimental Validation to Elucidate the Pharmacological Mechanisms of Luteolin Against Chondrocyte Senescence
CONCLUSION: In summary, luteolin demonstrated beneficial properties against aging and degeneration in EPCs, offering novel insights to mitigate the progression of intervertebral disc degeneration (IVDD).PMID:38299289 | DOI:10.2174/0113862073273675231114112804 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Ling Long Xiaokai Tang Yi Wang Jiaxiang Gu Jiachao Xiong Hao Luo Hao Lv Faxin Zhou Kai Cao Sijian Lin Source Type: research

Identification of Novel Hub Genes Associated with Inflammation and Autophagy in Astragaloside Membranaceus ameliorates Lupus Nephritis by Bioinformatics Analysis and Molecular Dynamics Simulation
CONCLUSION: IL-1β, CASP3, STAT1, and PPARγ could be potential biomarkers and therapeutic targets in AM ameliorates LN.PMID:38299290 | DOI:10.2174/0113862073255980231113071412 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Kaili Kong Xiaomei Qiao Ting Liu Xiaoxia Wang Rui Li Jingai Fang Xiaodong Zhang Source Type: research

GATA6 Suppresses Lung Adenocarcinoma Progression by Activating CFTR to Modulate Arachidonic Acid Metabolism
CONCLUSION: The activation of CFTR by GATA6 hampered LUAD progression by modulating the AA metabolism pathway, suggesting that GATA6/CFTR axis might be a therapeutic target for LUAD patients.PMID:38299406 | DOI:10.2174/0113862073269158240122072743 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Yong Lin Yushan Chen Yi Zhang Jianming Weng Rongqiang Shen Wenshan Zhang Yulin Lin Source Type: research

Investigating the Effect of Vitamin a on Orthodontic Tooth Movement: An Experimental Study
CONCLUSION: Despite the known effects of vitamin A on bone metabolism, the results of this study suggest that vitamin A did not increase alveolar bone remodeling and orthodontic tooth movement in male rats.PMID:38299407 | DOI:10.2174/0113862073273572240115105350 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Pengxiang Shi Jing Zhao Feng Wang Source Type: research

Prediction of Anti-rheumatoid Arthritis Natural Products of Xanthocerais Lignum Based on LC-MS and Artificial Intelligence
CONCLUSION: In this study, we utilized AI technology to learn from a large number of compounds and predict the activity of natural products from Xanthocerais lignum on specific targets. By combining AI technology and the LC-MS approach, rapid screening and prediction of the activity of natural products based on specific targets can be achieved, significantly enhancing the efficiency of discovering new bioactive molecules from medicinal plants.PMID:38299408 | DOI:10.2174/0113862073282138240116112348 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Hao Qian Zhibing Xiao Lei Su Yaqiong Yang XiangYang Tian Xiaoqin Wang Source Type: research

Clinical and Animal Studies of Waist and Knee Scraping Therapy for Knee Osteoarthritis
CONCLUSION: Scraping therapy can significantly alleviate knee joint pain and stiffness, improve joint function, and improve clinical efficacy, and the short-term and long-term effects of waist and knee scraping therapy are more significant. The scraping therapy has a definite therapeutic effect on KOA rats, which can improve the threshold of cold hyperalgesia and mechanical hyperalgesia, and the waist and knee scraping therapy is more obvious. This may be related to reducing inflammatory reactions in synovial and ganglion tissues.CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR230070623.PMID:38284729 | DOI:10.2174/01138620732643...
Source: Combinatorial Chemistry and High Throughput Screening - January 29, 2024 Category: Chemistry Authors: Qianhong Jin Mingrui Chen Jing Kong Dandan Chen Xuan Wu Xiaoqing Shi Lishi Jie Likai Yu Sha Li Zhengxiang Dai Source Type: research