DPP2/7 is a Potential Predictor of Prognosis and Target in Immunotherapy in Colorectal Cancer: An Integrative Multi-omics Analysis
CONCLUSION: DPP7 could serve as a CRC prognosis marker, functioning as an oncogene and representing a potential immunotherapeutic target.PMID:38454764 | DOI:10.2174/0113862073290831240229060932 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 8, 2024 Category: Chemistry Authors: Zhihao Shang Yueyang Lai Haibo Cheng Source Type: research

Daptomycin Inhibits Multiple Myeloma Progression through Downregulating the Expression of RPS19
CONCLUSION: DAP inhibited the proliferation, migration, and invasion and promoted the apoptosis of MM cells. Mechanistically, the RPS19 expression was significantly decreased in DAPtreated cells. This research provides a potential therapeutic drug for MM therapy.PMID:38454765 | DOI:10.2174/0113862073283460240129104114 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 8, 2024 Category: Chemistry Authors: Yijun Zhuang Yin Zhang Caiyun Chen Jincheng Chen Qiuxia Xu Peihong Wang Source Type: research

Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis
CONCLUSION: PLAC8 has promising application prospects as a biomarker for interstitial cystitis diagnosis. These findings could aid in the diagnosis and treatment of interstitial cystitis.PMID:38441011 | DOI:10.2174/0113862073273817231107050852 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Zhilei Zhang Mingwei Xu Xiangyan Zhang Fei Xie Xiaofei Zhang Peng Li Source Type: research

Integrated Serum Pharmacochemistry and Network Pharmacological Analysis Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides
CONCLUSION: The potential mechanisms of the anti-aging effect of ginsenosides involve multiple components, targets, and pathways. These findings serve as a foundation for further research into the processes behind ginsenoside's anti-aging impact.PMID:38441012 | DOI:10.2174/0113862073270652231115080745 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Jing Li Ruigang Li Qing Yang Xiaoran Liu Xiaobo Qu Na Li Source Type: research

Unraveling Amentoflavone's Therapeutic Potential in Alzheimer's Disease: A Preclinical Assessment
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073301291240229102657. Online ahead of print.ABSTRACTAlzheimer's disease is one of the neurodegenerative diseases which causes cognition deficit. There are currently few medications available to treat Alzheimer's disease, even though researchers have devoted a great deal of time studying the condition and offering many benefits. Thus, only a few drugs are available for the treatment of Alzheimer's disease. Amentoflavone is a dietary component found in many plants and herbs that has several health advantages. Amentoflavone has demonstrated strong protective b...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Plant Adaptation and Tolerance to Heat Stress: Advance Approaches and Future Aspects
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073300371240229100613. Online ahead of print.ABSTRACTHeat stress impacts plant growth at all phases of development, although the particular threshold for heat tolerance varies significantly across different developmental stages. During seed germination, elevated temperatures can either impede or completely halt the process, contingent upon the plant type and the severity of the stress. During advanced stages, high temperatures can have a negative impact on photosynthesis, respiration, water balance, and membrane integrity. Additionally, they can also influen...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Vineeta Pandey Sonia Singh Source Type: research

Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis
CONCLUSION: PLAC8 has promising application prospects as a biomarker for interstitial cystitis diagnosis. These findings could aid in the diagnosis and treatment of interstitial cystitis.PMID:38441011 | DOI:10.2174/0113862073273817231107050852 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Zhilei Zhang Mingwei Xu Xiangyan Zhang Fei Xie Xiaofei Zhang Peng Li Source Type: research

Integrated Serum Pharmacochemistry and Network Pharmacological Analysis Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides
CONCLUSION: The potential mechanisms of the anti-aging effect of ginsenosides involve multiple components, targets, and pathways. These findings serve as a foundation for further research into the processes behind ginsenoside's anti-aging impact.PMID:38441012 | DOI:10.2174/0113862073270652231115080745 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Jing Li Ruigang Li Qing Yang Xiaoran Liu Xiaobo Qu Na Li Source Type: research

Unraveling Amentoflavone's Therapeutic Potential in Alzheimer's Disease: A Preclinical Assessment
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073301291240229102657. Online ahead of print.ABSTRACTAlzheimer's disease is one of the neurodegenerative diseases which causes cognition deficit. There are currently few medications available to treat Alzheimer's disease, even though researchers have devoted a great deal of time studying the condition and offering many benefits. Thus, only a few drugs are available for the treatment of Alzheimer's disease. Amentoflavone is a dietary component found in many plants and herbs that has several health advantages. Amentoflavone has demonstrated strong protective b...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Plant Adaptation and Tolerance to Heat Stress: Advance Approaches and Future Aspects
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073300371240229100613. Online ahead of print.ABSTRACTHeat stress impacts plant growth at all phases of development, although the particular threshold for heat tolerance varies significantly across different developmental stages. During seed germination, elevated temperatures can either impede or completely halt the process, contingent upon the plant type and the severity of the stress. During advanced stages, high temperatures can have a negative impact on photosynthesis, respiration, water balance, and membrane integrity. Additionally, they can also influen...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Vineeta Pandey Sonia Singh Source Type: research

Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis
CONCLUSION: PLAC8 has promising application prospects as a biomarker for interstitial cystitis diagnosis. These findings could aid in the diagnosis and treatment of interstitial cystitis.PMID:38441011 | DOI:10.2174/0113862073273817231107050852 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Zhilei Zhang Mingwei Xu Xiangyan Zhang Fei Xie Xiaofei Zhang Peng Li Source Type: research

Integrated Serum Pharmacochemistry and Network Pharmacological Analysis Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides
CONCLUSION: The potential mechanisms of the anti-aging effect of ginsenosides involve multiple components, targets, and pathways. These findings serve as a foundation for further research into the processes behind ginsenoside's anti-aging impact.PMID:38441012 | DOI:10.2174/0113862073270652231115080745 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Jing Li Ruigang Li Qing Yang Xiaoran Liu Xiaobo Qu Na Li Source Type: research

Unraveling Amentoflavone's Therapeutic Potential in Alzheimer's Disease: A Preclinical Assessment
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073301291240229102657. Online ahead of print.ABSTRACTAlzheimer's disease is one of the neurodegenerative diseases which causes cognition deficit. There are currently few medications available to treat Alzheimer's disease, even though researchers have devoted a great deal of time studying the condition and offering many benefits. Thus, only a few drugs are available for the treatment of Alzheimer's disease. Amentoflavone is a dietary component found in many plants and herbs that has several health advantages. Amentoflavone has demonstrated strong protective b...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Plant Adaptation and Tolerance to Heat Stress: Advance Approaches and Future Aspects
Comb Chem High Throughput Screen. 2024 Mar 4. doi: 10.2174/0113862073300371240229100613. Online ahead of print.ABSTRACTHeat stress impacts plant growth at all phases of development, although the particular threshold for heat tolerance varies significantly across different developmental stages. During seed germination, elevated temperatures can either impede or completely halt the process, contingent upon the plant type and the severity of the stress. During advanced stages, high temperatures can have a negative impact on photosynthesis, respiration, water balance, and membrane integrity. Additionally, they can also influen...
Source: Combinatorial Chemistry and High Throughput Screening - March 5, 2024 Category: Chemistry Authors: Vineeta Pandey Sonia Singh Source Type: research

Quercetin Prevents HSpertension in Dahl Salt-sensitive Rats Fed a High-salt Diet Through Balancing Endothelial Nitric Oxide Synthase and Sirtuin 1
CONCLUSION: Quercetin reduced blood pressure by enhancing the expression of SIRT1 and eNOS in Dahl SS rats fed a high-salt diet.PMID:38415447 | DOI:10.2174/0113862073284196240214082904 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 28, 2024 Category: Chemistry Authors: Guanji Wu Fuqiang Liu Qing Cui Tao Zhang Junjun Hao Jianjun Bao Source Type: research