Combinatorial Chemistry and High Throughput Screening 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Microfluidics-assisted Tumor Cell Separation Approaches for Clinical Applications: An Overview on Emerging Devices
Comb Chem High Throughput Screen. 2024 Jan 24. doi: 10.2174/0113862073277130231110111933. Online ahead of print.ABSTRACTRecent advances in science and technology have led to revolutions in many different scientific and industrial fields. The term lab on a chip, or in other word, performing a variety of complex analyzes in just a short time and in a very small space, is a term that has become very common in recent years, and what used to be a dream has now come to life in practice. In this paper, we has been tried to investigate a specific type of lab technology on a chip, which is of course one of the most common, namely t...
Source: Combinatorial Chemistry and High Throughput Screening - January 26, 2024 Category: Chemistry Authors: Nahid Shanehband Seyed Morteza Naghib Source Type: research
Network Pharmacology Study on the Underlying Mechanism of Danggui-Kushen Herb Pair in Adjuvant Chemotherapeutics against Breast Cancer
CONCLUSION: Hyperforin, kushenin, kushenol T, and other active compounds in DKHP can regulate multiple signaling pathways and targets, such as AKT1, TP53, and CASP3, thereby playing preventive and therapeutic roles in BC.PMID:38275061 | DOI:10.2174/0113862073256883231120070039 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 26, 2024 Category: Chemistry Authors: Yijuan Hu Jiaolong He Yunling Xu Source Type: research
Association of CirAEs and Efficacy in NSCLC Patients Treated with PD-1/PD-L1: A Meta-analysis of Cohort Studies
CONCLUSION: Currently, evidence reveals that cirAEs development may be associated with a good prognosis and can be an early predictor of the efficacy of PD-1/PD-L1 in the treatment of NSCLC patients.PMID:38265378 | DOI:10.2174/0113862073267261231106093845 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 24, 2024 Category: Chemistry Authors: Junru Lu Jiaming Zhu Guan Jiang Source Type: research
Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders
Comb Chem High Throughput Screen. 2024 Jan 12. doi: 10.2174/0113862073280680240101065732. Online ahead of print.ABSTRACTNeurodegeneration causes premature death in the peripheral and central nervous system. Neurodegeneration leads to the accumulation of oxidative stress, inflammatory responses, and the generation of free radicals responsible for nervous disorders like amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders. Therefore, focus must be diverted towards treating and managing these disorders, as it is very challenging. Furthermore, effective therapies are also lacking,...
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2024 Category: Chemistry Authors: Sonia Singh Ashima Ahuja Shilpi Pathak Source Type: research
Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer
CONCLUSION: Our findings indicate that GpM exerts its anti-tumor effect on EC by inhibiting EC cell migration and invasion via downregulation of the PI3K/AKT signaling pathway. Hence, we have reason to believe that GpM could be a promising candidate for the treatment of EC.PMID:38243957 | DOI:10.2174/0113862073280183240108113853 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2024 Category: Chemistry Authors: Jianxin Guo Zhongbing Wu Xiaoyue Chang Ming Huang Yu Wang Renping Liu Jing Li Source Type: research
Use of Network Pharmacology and Experiment Validation to Uncover the Mechanism of Jianshen Lishui Prescription in the Treatment of Intracerebral Hemorrhage
CONCLUSION: Jianshen Lishui prescription protects the nerve function of ICH patients by inhibiting inflammation and reducing cerebral edema. This study provides more supportive evidences for the clinical use of traditional Chinese prescriptions in ICH treatment.PMID:38243958 | DOI:10.2174/0113862073256436231031100059 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2024 Category: Chemistry Authors: Gao Yuguang Huang Deqing Zhong Jie Ma Yujuan Yang Kan Liao Yuxiong Zhu Qiong Liu Qiqi Source Type: research
Nuclear Factor Kappa B: A Nobel Therapeutic Target of Flavonoids Against Parkinson's Disease
Comb Chem High Throughput Screen. 2024 Jan 18. doi: 10.2174/0113862073295568240105025006. Online ahead of print.ABSTRACTParkinson's disease (PD), the most common brain-related neurodegenerative disorder, is comprised of several pathophysiological mechanisms, such as mitochondrial dysfunction, neuroinflammation, aggregation of misfolded alpha-synuclein, and synaptic loss in the substantia nigra pars compacta region of the midbrain. Misfolded alpha-synuclein, originating from damaged neurons, triggers a series of signaling pathways in both glial and neuronal cells. Activation of such events results in the production and expr...
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2024 Category: Chemistry Authors: Niraj Kumar Singh Ashini Singh None Mayank Source Type: research
The Role of Innate Immunity in Osteoarthritis and the Connotation of "Immune-joint" Axis: A Narrative Review
Comb Chem High Throughput Screen. 2024 Jan 18. doi: 10.2174/0113862073264389231101190637. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a degenerative disease that results in constriction of the joint space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial membrane. Recently, scientists have found that OA involves lesions in the whole joint, in addition to joint wear and tear and cartilage damage. Osteoarthritis is often accompanied by a subclinical form of synovitis, which is a chronic, relatively low-grade inflammatory response mainly mediated by the innate immune system....
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2024 Category: Chemistry Authors: Gaoyan Kuang Xuyi Tan Xin Liu Naping Li Nanxing Yi Yilin Mi Qiyun Shi Fan Zeng Xinjun Xie Min Lu Xiaotong Xu Source Type: research
Screening for Biomarkers Related to Pigmentation and Formation in Vitiligo
CONCLUSION: The hub genes obtained in this study may be a biomarker related to the development of vitiligo pigmentation. Our research not only contributes to a better understanding of the treatment mechanisms of vitiligo but also provides valuable insights for future personalized medical approaches and targeted therapies for vitiligo.PMID:38231049 | DOI:10.2174/0113862073275508231229112157 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 17, 2024 Category: Chemistry Authors: Ying Shi Mengyun Su Source Type: research
TOMM40 Correlates with Cholesterol and is Predictive of a Favorable Prognosis in Endometrial Carcinoma
CONCLUSION: The findings of our study indicate that the maintenance of normal total cholesterol metabolism is associated with a decreased risk of developing endometrial cancer. Moreover, TOMM40 may have potential as a prognostic indicator for endometrial cancer.PMID:38231050 | DOI:10.2174/0113862073270411240102060240 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 17, 2024 Category: Chemistry Authors: Yan Chen Yi Luo Jinling Long Siyun Liu Linbeini Zhao Baishu Chen Qiuyun Mu Source Type: research
Investigation of the Potential Mechanism of Compound Dragon's Blood Capsule against Myocardial IschemiaBased on Network Pharmacology
CONCLUSION: CDC has a significant anti-myocardial ischemia effect through the PI3k/Akt pathway, which demonstrates that CDC is a suitable adjuvant to treat CHD and provides a theoretical basis for its further clinical application.PMID:38231051 | DOI:10.2174/0113862073264485240102064653 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 17, 2024 Category: Chemistry Authors: Xin Su Hongwei Xue Yang Lou Xinkai Lv Xiao Mi Juan Lu Xi Chen Source Type: research
Mechanism of Tonifying Spleen-lung Recipe in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Observational Data
CONCLUSION: TSLR had a good therapeutic effect on chronic bronchitis patients, which might be related to the fact that the natural active components in TSLR inhibit inflammation by regulating the expression of proteins related to PI3K-AKT and TNF signaling pathways.PMID:38213144 | DOI:10.2174/0113862073274028231213105142 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 12, 2024 Category: Chemistry Authors: Hongjin Wu Shenguang Li Xiaomei Du Kaigong Zhu Jing Li Source Type: research
The Potential Association of TFR1/SLC11A2/GPX4 with Ferroptosis in Mediating Lipid Metabolism Disorders in Atherosclerosis
CONCLUSION: Ferroptosis exacerbated the lipid metabolism disorder in atherosclerotic mice. The core mechanism of its effect is that ferroptosis activates the TFR1/SLC11A2/GPX4 signaling pathway, which leads to the up-regulation of oxidative stress in ApoE-/- mice, and ultimately aggravates the abnormal lipid metabolism in ApoE-/- mice.PMID:38213145 | DOI:10.2174/0113862073271348231213071225 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 12, 2024 Category: Chemistry Authors: Yuan Cao Nan Song Ying Wang Xue Leng Qun Wang Yixin Ma Si Chen Xing Ju Lianqun Jia Source Type: research
Total Glucosides of Paeony Induce Mitochondrial Dysfunction and Apoptosis by Promoting the Degradation of α5-nAChR in Melanoma Cells
CONCLUSION: TGP inhibited cell viability and migration and induced mitochondrial dysfunction and apoptosis by promoting the degradation of α5-nAChR in melanoma cells. This research provided a potential therapeutic anti-cancer drug for treatment strategies of melanoma.PMID:38213146 | DOI:10.2174/0113862073271585231129172213 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 12, 2024 Category: Chemistry Authors: Xianguang Meng Ling Cheng Jing Jiao Yuanxin Xing Li Zhang Source Type: research
On Certain Degree Based and Bond-Additive Topological Indices of Dodeca-Benzo-Circumcorenene
CONCLUSION: The computed indices are then compared graphically to study their relationship with the molecular structure and with each other.</p>.PMID:38213147 | DOI:10.2174/0113862073274943231211110011 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 12, 2024 Category: Chemistry Authors: T Gunasekar P Kathavarayan Ammar Alsinai G Murugan Source Type: research
