Total Glucosides of Paeony Induce Mitochondrial Dysfunction and Apoptosis by Promoting the Degradation of α5-nAChR in Melanoma Cells

CONCLUSION: TGP inhibited cell viability and migration and induced mitochondrial dysfunction and apoptosis by promoting the degradation of α5-nAChR in melanoma cells. This research provided a potential therapeutic anti-cancer drug for treatment strategies of melanoma.PMID:38213146 | DOI:10.2174/0113862073271585231129172213
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Source Type: research