Eli Lilly's Arthritis Drug Fails to Prevent Mechanical Ventilation in COVID-19 Patients Eli Lilly's Arthritis Drug Fails to Prevent Mechanical Ventilation in COVID-19 Patients
Eli Lilly and Incyte said their rheumatoid arthritis drug baricitinib did not meet the main goal of preventing progression to mechanical ventilation in hospitalized COVID-19 patients under a late-stage study.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - April 9, 2021 Category: Orthopaedics Tags: Infectious Diseases News Source Type: news

Rheumatoid arthritis: Three early indicators warning of your risk
RHEUMATOID is a general term for pain and inflammation in a joint. The symptoms can be insufferable but what are the main indicators warning of your risk? (Source: Daily Express - Health)
Source: Daily Express - Health - April 8, 2021 Category: Consumer Health News Source Type: news

NIDCR's Spring 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR & NIH Stand Against Structural Racism NIDCR Director Rena D’Souza, DDS, MS, PhD, said in a statement that there is no place for structural racism in biomedical research, echoing remarks from NIH Director Francis Collins, MD, PhD, in his announcement of a new NIH ...
Source: NIDCR Science News - April 7, 2021 Category: Dentistry Source Type: news

Will the Covid vaccine protect people who had to shield?
Actress Sheila Hancock, 88, recently revealed that she has been warned that the treatment she receives for rheumatoid arthritis (RA) may affect the efficacy of her Covid-19 vaccine. (Source: the Mail online | Health)
Source: the Mail online | Health - April 5, 2021 Category: Consumer Health News Source Type: news

Arthritis: Four stages of the progressive disease rheumatoid arthritis
ARTHRITIS can be a sign of an autoimmune condition, where the body mistakenly attacks its own joints. This is known as rheumatoid arthritis, which is a progressive disease. What are the warning signs? (Source: Daily Express - Health)
Source: Daily Express - Health - April 4, 2021 Category: Consumer Health News Source Type: news

Hydroxychloroquine valid option in autoantibody-negative rheumatoid arthritis
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - April 1, 2021 Category: Drugs & Pharmacology Source Type: news

Rheumatoid arthritis symptoms: The four warning signs in your fingers - 'numb, tingle'
RHEUMATOID arthritis is a long-term condition that causes pain, swelling and stiffness in the joints. There are four warning signs in your fingers and hands that can indicate carpal tunnel syndrome - a complication of rheumatoid arthritis. (Source: Daily Express - Health)
Source: Daily Express - Health - March 31, 2021 Category: Consumer Health News Source Type: news

Rheumatoid arthritis symptoms: Four telltale signs on your hands and fingers
RHEUMATOID arthritis is a long-term condition that causes pain, swelling and stiffness in the joints. There are four warning signs in your fingers and hands that can indicate carpal tunnel syndrome - a complication of rheumatoid arthritis. (Source: Daily Express - Health)
Source: Daily Express - Health - March 31, 2021 Category: Consumer Health News Source Type: news

Repurposing tocilizumab in scleroderma patients may prevent early lung disease
(Michigan Medicine - University of Michigan) A phase 3 clinical trial finds an anti-inflammatory drug used in rheumatoid arthritis can preserve lung function in patients with systemic sclerosis. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 31, 2021 Category: International Medicine & Public Health Source Type: news

Rheumatoid arthritis symptoms: Three signs you will develop arthritis in the future
RHEUMATOID arthritis is an incurable joint condition that affects more than 400,000 people in the UK. Research has identified the most "efficient predictors" of the condition developing. (Source: Daily Express - Health)
Source: Daily Express - Health - March 30, 2021 Category: Consumer Health News Source Type: news

In-Hospital Cardiac Procedures Up for Those With Gout, RA
TUESDAY, March 30, 2021 -- Rates of in-hospital cardiac procedures continued to increase in people with gout and rheumatoid arthritis (RA) from 1998 to 2014, although they decreased for the general population, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 30, 2021 Category: Pharmaceuticals Source Type: news

CVD Risk Factors Tied to Disease Activity, Disability in RA
MONDAY, March 29, 2021 -- Cardiovascular disease (CVD) risk factors alone, or in combination, are associated with higher disease activity and disability in rheumatoid arthritis (RA), according to a study recently published in Therapeutic Advances in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 29, 2021 Category: Pharmaceuticals Source Type: news

Inflammation-fighting protein could improve treatment of rheumatoid arthritis
(Washington State University) New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system attacks the body's own joint tissues. Published in the journal Arthritis& Rheumatology, the discovery could someday lead to new treatments to slow or halt the progress of the disease, which affects an estimated 1.5 million Americans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2021 Category: International Medicine & Public Health Source Type: news

Researchers Explore the Association Between Rheumatoid Arthritis and Comorbid Conditions
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - March 28, 2021 Category: Orthopaedics Tags: CME Article Source Type: news

Rheumatoid arthritis symptoms: The three most commonly reported early warning signs
RHEUMATOID arthritis is an autoimmune disease, which means the body's immune system targets affected joints. Research suggests there are three common initial symptoms to watch out for. (Source: Daily Express - Health)
Source: Daily Express - Health - March 27, 2021 Category: Consumer Health News Source Type: news

Arthritis symptoms: Four unusual signs of rheumatoid arthritis
RHEUMATOID arthritis can have a number of symptoms, the most common of which includes stiff, painful joints combined with fatigue. But here are four unusual signs of rheumatoid arthritis you should look out for. (Source: Daily Express - Health)
Source: Daily Express - Health - March 26, 2021 Category: Consumer Health News Source Type: news

Efficacy and Safety of Adalimumab Biosimilar CT-P17 for RA Efficacy and Safety of Adalimumab Biosimilar CT-P17 for RA
Is this adalimumab biosimilar for the treatment of rheumatoid arthritis as safe and effective as the reference product?Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 26, 2021 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Noninvasive Vagus Nerve Stimulation Tolerated, Effective for Rheumatoid Arthritis Noninvasive Vagus Nerve Stimulation Tolerated, Effective for Rheumatoid Arthritis
Noninvasive vagus nerve stimulation is safe and effective as an intervention for rheumatoid arthritis, a small proof-of-concept study suggests.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - March 22, 2021 Category: Orthopaedics Tags: Rheumatology News Source Type: news

Can medicines that block interleukin-6 (a protein involved in immune responses) treat COVID-19?
This recently published Cochrane review examines the effects of a class of treatments on people with COVID-19.  Treating COVID-19 with tocilizumab (a medicine that blocks interleukin-6) reduces the numbers of people who die within 28 days of treatment, and probably results in fewer serious unwanted effects than placebo treatment.Studies of other medicines that block interleukin-6 to treat COVID-19 are under way. The authors of this review will update this review when results from them become available.COVID-19COVID-19 is an infectious respiratory disease caused by a type of virus called a coronavirus. If the infection...
Source: Cochrane News and Events - March 18, 2021 Category: Information Technology Authors: Katie Abbotts Source Type: news

Study finds inflammatory mechanism responsible for bone erosion in rheumatoid arthritis
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at a FAPESP-supported research center identified a novel pathway in the inflammatory process relating to bone damage. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 18, 2021 Category: International Medicine & Public Health Source Type: news

Fear-of-falling and associated risk factors in persons with rheumatoid arthritis: a 1  year prospective study - Stanmore EK, Oldham J, Skelton DA, O'Neill T, Pilling M, Todd C.
BACKGROUND: Falls, associated injuries and fear-of-falling are common in adults with RA. Fear-of-falling can be a major consequence of, and as debilitating as falling, resulting in a cycle of activity restriction, reduced quality of life, institutionalisat... (Source: SafetyLit)
Source: SafetyLit - March 17, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Immune receptor protein could hold key to treatment of autoimmune diseases
(Tokyo University of Science) TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models. They found that TARM1 activated dendritic cells, and development of collagen-induced arthritis (CIA) was notably suppressed in TARM1-deficient mice and by treatment with TARM1-inhibitory soluble TARM1 proteins. This makes the protein a potential therapeutic target. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2021 Category: International Medicine & Public Health Source Type: news

My Life With Rheumatoid Arthritis
Their diagnosis is the same, but their experiences are unique. Follow Andy, Ryn, and Molly as they share stories from their lives with RA. (Source: WebMD Health)
Source: WebMD Health - March 16, 2021 Category: Consumer Health News Source Type: news

Checkpoint Inhibitor Rheumatic Complications Often Arise Late Checkpoint Inhibitor Rheumatic Complications Often Arise Late
Most checkpoint inhibitor-induced rheumatic complications in patients with cancer can be treated successfully with corticosteroids, albeit often at considerably higher doses than rheumatologists typically use in managing rheumatoid arthritis, says an expert.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 16, 2021 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Arthritis symptoms: Three signs in your eyes that could signal rheumatoid arthritis
ARTHRITIS is a condition that famously causes pain and inflammation in a person's joints. But research shows inflammation can cause damage to other parts of the body including the eyes. What signs should you look out for? (Source: Daily Express - Health)
Source: Daily Express - Health - March 16, 2021 Category: Consumer Health News Source Type: news

A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets
In the peripheral nervous system, ligand-receptor interactions between cells and neurons shape sensory experience, including pain. We set out to identify the potential interactions between sensory neurons and peripheral cell types implicated in disease-associated pain. Using mouse and human RNA sequencing datasets and computational analysis, we created interactome maps between dorsal root ganglion (DRG) sensory neurons and an array of normal cell types, as well as colitis-associated glial cells, rheumatoid arthritis–associated synovial macrophages, and pancreatic tumor tissue. These maps revealed a common correlation...
Source: Signal Transduction Knowledge Environment - March 16, 2021 Category: Science Authors: Wangzhou, A., Paige, C., Neerukonda, S. V., Naik, D. K., Kume, M., David, E. T., Dussor, G., Ray, P. R., Price, T. J. Tags: STKE Research Resources Source Type: news

Arthritis symptoms: Three 'mystery' signs of painful arthritis you may be missing
ARTHRITIS symptoms usually include joint pain, inflammation, and restricted movement. But there are also some "mystery" signs of arthritis that you may be missing. These are the three unusual symptoms of rheumatoid arthritis you shouldn't ignore, including dry eyes and easy bruising. (Source: Daily Express - Health)
Source: Daily Express - Health - March 12, 2021 Category: Consumer Health News Source Type: news

Combo of Genentech, Gilead drugs fails Covid trial
The study is one of three late-stage clinical trials that Genentech has undertaken to assess the use of the rheumatoid arthritis drug Actemra in Covid patients with pneumonia. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 11, 2021 Category: American Health Authors: Ron Leuty Source Type: news

Combo of Genentech, Gilead drugs fails Covid trial
The study is one of three late-stage clinical trials that Genentech has undertaken to assess the use of the rheumatoid arthritis drug Actemra in Covid patients with pneumonia. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 11, 2021 Category: Biotechnology Authors: Ron Leuty Source Type: news

Cochrane Library Editorial - Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID-19
During the past 12 months chloroquine and hydroxychloroquine have been touted as cures for COVID-19 and introduced into Covid-19 treatment protocols. This has led to increases in demand, leaving some rheumatoid arthritis and lupus patients deprived of effective treatments.A newly publishedCochrane Library Editorial explores the story of the assessment of  chloroquine and hydroxychloroquine efficacy and the lessons learnt. This Editorial publishes alongside the  recently published review published in the Cochrane Library   that concludes that hydroxychloroquine   has no clinical benefit in...
Source: Cochrane News and Events - March 9, 2021 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Rheumatoid arthritis treatment: 'Modified' fasting may improve symptoms
RHEUMATOID arthritis is an incurable joint condition that can greatly diminish one's quality of life. Fortunately, you can improve symptoms through modified fasting - what is it? (Source: Daily Express - Health)
Source: Daily Express - Health - March 8, 2021 Category: Consumer Health News Source Type: news

Tocilizumab cuts mortality risk in severely ill COVID-19 patients finds new trial conducted in India
Tocilizumab, an anti-inflammatory drug used to treat rheumatoid arthritis, improves outcomes in severely ill COVID-19 patients, finds the results of a new trial conducted in hospitals across India — one of the world ’ s most ethnically diverse countries. (Source: University of Bristol news)
Source: University of Bristol news - March 8, 2021 Category: Universities & Medical Training Tags: Health, International, Publications, Research; Faculty of Health Sciences, Bristol Medical School; Press Release Source Type: news

Tocilizumab cuts mortality risk in severely ill COVID-19 patients finds new trial conducted in India
(University of Bristol) Tocilizumab, an anti-inflammatory drug used to treat rheumatoid arthritis, improves outcomes in severely ill COVID-19 patients, finds the results of a new trial conducted in hospitals across India -- one of the world's most ethnically diverse countries. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 8, 2021 Category: International Medicine & Public Health Source Type: news

Rheumatoid arthritis symptoms: The sensation of 'sand in eye' is a telltale sign
RHEUMATOID arthritis mainly affect the joints but the symptoms do not stop there. Occasionally, eye problems can signal the joint condition, which include the sensation of sand in the eye. (Source: Daily Express - Health)
Source: Daily Express - Health - March 5, 2021 Category: Consumer Health News Source Type: news

RA Experts Highlight Key Developments Over the Past Year RA Experts Highlight Key Developments Over the Past Year
A massive Swedish cohort study suggesting that biologic agents reduce the known excess risk of lymphoma in patients with rheumatoid arthritis was hailed as one of the high points of the last year.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - March 5, 2021 Category: Rheumatology Tags: Rheumatology News Source Type: news

Micromotors Promising for Rheumatoid Arthritis Therapy Micromotors Promising for Rheumatoid Arthritis Therapy
Magnesium-based micromotors showed promise as a delivery system for hydrogen therapy to inflamed joints in an experimental model of rheumatoid arthritis, researchers say.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - March 5, 2021 Category: Orthopaedics Tags: Rheumatology News Source Type: news

Rheumatoid arthritis symptoms: Nodules under your skin are a visual clue of arthritis
RHEUMATOID arthritis is an autoimmune disease that causes a number of joint problems. Lumps under the skin of bony areas can signal you have rheumatoid arthritis. (Source: Daily Express - Health)
Source: Daily Express - Health - March 2, 2021 Category: Consumer Health News Source Type: news

Lupin launches generic drug to treat Wilson's disease in US market
The Mumbai-based drug firm's product is the generic equivalent of Mylan Specialty's Depen tablets, which are indicated for the treatment of Wilson's disease, Cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 2, 2021 Category: Pharmaceuticals Source Type: news

GSK Will Focus on Elderly in Trial to Treat Pneumonia From COVID GSK Will Focus on Elderly in Trial to Treat Pneumonia From COVID
GlaxoSmithKline will extend a trial testing an experimental rheumatoid arthritis drug on patients suffering from COVID-related pneumonia in order to focus on the elderly.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 26, 2021 Category: Orthopaedics Tags: Pulmonary Medicine News Source Type: news

Rheumatoid Arthritis Meds May Help Fight Severe COVID
Rheumatoid arthritis drugs may save lives of patients hospitalized with severe cases of COVID-19, according to a groundbreaking clinical trial. (Source: WebMD Health)
Source: WebMD Health - February 26, 2021 Category: Consumer Health News Source Type: news

Rheumatoid Arthritis Meds May Help Fight Severe COVID-19
FRIDAY, Feb. 26, 2021 -- Rheumatoid arthritis drugs may save lives of patients hospitalized with severe cases of COVID-19, according to a groundbreaking clinical trial. The findings, first announced in January, have now been peer-reviewed and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 26, 2021 Category: General Medicine Source Type: news

Hepatotoxicity Risk Differs Between Psoriasis, PsA, and RA Patients Hepatotoxicity Risk Differs Between Psoriasis, PsA, and RA Patients
Patients taking methotrexate for psoriasis or psoriatic arthritis were at a higher risk of developing liver disease than were patients with rheumatoid arthritis on methotrexate.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - February 26, 2021 Category: Rheumatology Tags: Rheumatology News Source Type: news

Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients
Treating critically ill COVID-19 patients with drugs typically used for rheumatoid arthritis may significantly improve survival, a landmark study has found. The findings, which were announced in January and have now been peer-reviewed and published in the New England Journal of Medicine, come from the REMAP-CAP trial, which evaluates the effect of treatments on a combination of survival and length of time patients need support in an intensive care unit (ICU). (Source: World Pharma News)
Source: World Pharma News - February 26, 2021 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Therapies May Influence Persistent Pain in Early Rheumatoid Arthritis
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - February 26, 2021 Category: Orthopaedics Tags: CME Article Source Type: news

Treatment to Lower RA Disease Activity Feasible in Pregnancy
THURSDAY, Feb. 25, 2021 -- Low disease activity and remission are feasible goals for women with rheumatoid arthritis (RA) cared for with a modern treatment approach during pregnancy, according to a study published online Feb. 10 in the Annals of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 25, 2021 Category: Pharmaceuticals Source Type: news

Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients
(Imperial College London) Treating critically ill COVID-19 patients with drugs typically used for rheumatoid arthritis may significantly improve survival, a landmark study has found. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 25, 2021 Category: Infectious Diseases Source Type: news

Does COVID-19 Make Rheumatoid Arthritis Worse
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 24, 2021 Category: General Medicine Source Type: news

Risk for Rheumatoid Arthritis Reduced for Patients With T2DM
TUESDAY, Feb. 23, 2021 -- Patients with type 2 diabetes mellitus (T2DM) have a reduced risk for rheumatoid arthritis (RA), which may be due to statin use, according to a study published online Feb. 16 in Rheumatology. Dawit T. Zemedikun, Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 23, 2021 Category: Pharmaceuticals Source Type: news

Drug companies look to AI to end 'hit and miss' research
Technology that speeded the development of Covid vaccines has potential to transform the pharmaceutical industryThe hunt for new medicines has often been more like a game of roulette than high-end science. But now the pharmaceutical sector is on the cusp of a transformation, as it delves into cutting-edge technology to come up with new treatments for diseases such as cancer, rheumatoid arthritis and Alzheimer ’s.Artificial intelligence (AI) is set to improve the industry ’s success rates and speed up drug discovery, potentially saving it billions of dollars, arecent survey by the analytics firm GlobalData has f...
Source: Guardian Unlimited Science - February 20, 2021 Category: Science Authors: Julia Kollewe Tags: Pharmaceuticals industry AstraZeneca GlaxoSmithKline Artificial intelligence (AI) Technology Drugs Science Business UK news Computing Source Type: news

Glucocorticoids Linked to a Higher Risk of Hypertension Glucocorticoids Linked to a Higher Risk of Hypertension
Glucocorticoids are commonly used in the treatment of rheumatoid arthritis, but exposure to these drugs may increase the risk of hypertension in these patients.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 19, 2021 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news