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FDA declines to approve J & J arthritis drug sirukumab
(Reuters) - The U.S. Food and Drug Administration has declined to approve Johnson& Johnson's rheumatoid arthritis drug sirukumab, saying additional clinical data is needed to further evaluate its safety, the company said on Friday. (Source: Reuters: Health)
Source: Reuters: Health - September 22, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

U.S. FDA declines to approve J & J arthritis drug
(Reuters) - The U.S. Food and Drug Administration has declined to approve Johnson& Johnson's rheumatoid arthritis drug sirukumab, saying additional clinical data is needed to further evaluate its safety, the company said on Friday. (Source: Reuters: Health)
Source: Reuters: Health - September 22, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Rheumatoid arthritis symptoms - what is the condition and who is at risk?
RHEUMATOID arthritis is a long term condition which mainly affects the hands, feet and wrists. (Source: Daily Express - Health)
Source: Daily Express - Health - September 20, 2017 Category: Consumer Health News Source Type: news

RA-Specific Variables Linked to CV Disease Events (CME/CE)
(MedPage Today) -- Risk for rheumatoid arthritis disease activity, seropositivity comparable to those of cholesterol (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - September 18, 2017 Category: Geriatrics Source Type: news

Dame Margaret Turner-Warwick obituary
Pioneering physician who played a fundamental role in the development of modern respiratory medicineWhen Margaret Turner-Warwick, who has died aged 92, entered the field of respiratory medicine in the 1950s, it was a time of great change. Effective treatment fortuberculosis had recently been introduced, and the adverse effects of cigarette smoking on the lung were beginning to be appreciated.The focus of academic research had been limited to understanding and measuring lung function, but with her colleagues Jack Pepys andDeborah Doniach, Margaret expanded it to include the immunology of the lung, and particularly of the fi...
Source: Guardian Unlimited Science - September 18, 2017 Category: Science Authors: Anthony Newman Taylor Tags: Medical research Science Health Society Health policy Public services policy Politics Source Type: news

Novartis says biosimilar rituximab accepted for review by FDA
ZURICH (Reuters) - Novartis AG said on Tuesday its biosimilar rituximab to treat blood cancers and immunological diseases such as rheumatoid arthritis was accepted for review by the U.S. Food and Drug Administration (FDA). (Source: Reuters: Health)
Source: Reuters: Health - September 12, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

AbbVie says deaths in arthritis trial not linked to drug
(Reuters) - AbbVie Inc said on Monday two patients died in a late-stage trial of its rheumatoid arthritis drug but that the deaths were not linked to the drug, which met the study's main goals. (Source: Reuters: Health)
Source: Reuters: Health - September 11, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

AbbVie dips after two patient deaths in rheumatoid arthritis study
(Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - September 11, 2017 Category: Pharmaceuticals Source Type: news

AbbVie reports two patient deaths in rheumatoid arthritis study
(Reuters) - AbbVie Inc said on Monday two patients died in a late-stage trial testing its drug to treat patients with moderate to severe rheumatoid arthritis. (Source: Reuters: Health)
Source: Reuters: Health - September 11, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Joint pain: Are your symptoms a signs of osteoarthritis or rheumatoid arthritis?
ARTHRITIS is a common condition which can cause painful symptoms. The two main types of the condition are osteoarthritis and rheumatoid arthritis - but the symptoms can be easily confused. (Source: Daily Express - Health)
Source: Daily Express - Health - September 11, 2017 Category: Consumer Health News Source Type: news

Could electrical implants replace pills for some illnesses?
A pacemaker-liked device that ‘hacks’ the body’s neural circuits could alleviate symptoms of diseases from rheumatoid arthritis to Crohn’s, say researchersA pioneering approach to tackling a host of diseases using an electrical implant could eventually reduce or even end pill-taking for some patients, researchers have claimed.The technology relies on electrical stimulation of the vagus nerve – a bundle of nerve fibres that runs from the brain to the abdomen, branching off to organs including the heart, spleen, lungs and gut, and which relays signals from the body’s organs to the brain an...
Source: Guardian Unlimited Science - September 8, 2017 Category: Science Authors: Nicola Davis Tags: Medical research Science Technology Health Biology Society Source Type: news

Lab notes: there's a hole (near) my heart that can only be filled by ... this week's science!
The most exciting story this week is kind of about nothing ... but a very big nothing.Astronomers have found evidence of enormous black hole one hundred thousand times more massive than the sun hiding in a gas cloud near the galaxy ’s centre. It’s not just a big hole though: it could help us understand how supermassive black holes form. And while we’re still gazing heavenward, everyone’s favourite dwarf planet,Pluto, has had its surface features officially named. Pluto ’s mountains, craters and regions now celebrate global mythology, explorers, map-makers and a British schoolgirl, among others...
Source: Guardian Unlimited Science - September 8, 2017 Category: Science Authors: Tash Reith-Banks Tags: Science Source Type: news

Rheumatoid arthritis symptoms - is fist clenching a warning sign?
ARTHRITIS is a very common condition in the UK - but it is commonly thought to be a condition which only affects the elderly. (Source: Daily Express - Health)
Source: Daily Express - Health - September 7, 2017 Category: Consumer Health News Source Type: news

One in 10 men aged 50 'have the heart of a 60-year-old'
"One-tenth of 50-year-old men have a heart age 10 years older than they are," BBC News reports. This is the finding of an analysis of 1.2 million people who used the NHS Heart Age Test. The principle behind the test is that you can "age" your heart through unhealthy behaviour such as smoking and being obese. Underlying conditions like high blood pressure and high cholesterol, which often have no noticeable symptoms, can also age the heart. An obese smoker in their 50s who has high blood pressure and high cholesterol could have the heart of a 60- or 70-year-old. The quick and simple test tells you the...
Source: NHS News Feed - September 4, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Campaigner Frances who lives with arthritis tells us why she is going to party conferences
I was 23 when I was diagnosed with rheumatoid arthritis . I had trained to be a teacher but it became clear that it would no longer be possible for me to keep up with a class and spend long hours standing. It wasn’t the life I expected to live.You have to make a new life, and let go of what you thought was going to happen. Arthritis can affect every aspect of your existence, from your career to your relationships and social life. As well as the big changes, there are little things too, for example I can find it a struggle to take the cap off a bottle of water.I am joining Arthritis Research UK at party conferences to...
Source: Arthritis Research UK - September 3, 2017 Category: Rheumatology Source Type: news

Lilly lays out faster time frame for FDA drug resubmission
Eli Lilly says it will resubmit its potential rheumatoid arthritis treatment to regulators several months faster than expected (Source: ABC News: Health)
Source: ABC News: Health - August 30, 2017 Category: Consumer Health News Tags: Health Source Type: news

Anti-inflammatory drug may help prevent heart attacks
Conclusion This well-conducted study shows promising signs that canakinumab may reduce the risk of future heart attacks and other cardiovascular events in people who've had them in the past. But before any changes are made to the current licensing of this drug, further research is needed to confirm the beneficial effects and the optimal dose. Most importantly, researchers will need to focus on the observation that the drug lowered white blood cell counts and increased the risk of fatal infection. They estimated around 1 in every 300 people taking canakinumab would die of a fatal infection. This number, while low, is sti...
Source: NHS News Feed - August 30, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Autoimmune diseases raise cardiovascular, mortality risk
A new study from researchers in Spain has found autoimmune diseases such as rheumatoid arthritis increase risk for cardiovascular disease and death. (Source: Health News - UPI.com)
Source: Health News - UPI.com - August 29, 2017 Category: Consumer Health News Source Type: news

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling
Cytoskeletal reorganization in osteoclasts to form actin rings is necessary for these cells to attach to bone and resorb bone matrices. We delineated the pathway through which Wnt5a signaling through receptor tyrosine kinase–like orphan receptor 2 (Ror2) promoted the bone-resorbing activity of osteoclasts. Wnt5a binding to Ror2 stimulated Rho, a small GTPase involved in cytoskeletal reorganization. Subsequently, the Rho effector kinase Pkn3 bound to and enhanced the activity of c-Src, a nonreceptor tyrosine kinase that is critical for actin ring formation. Mice with an osteoclast-specific deficiency in Ror2 (Ror2Ocl/...
Source: Signal Transduction Knowledge Environment - August 29, 2017 Category: Science Authors: Uehara, S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami, K., Nishita, M., Nakamura, T., Kato, S., Minami, Y., Takahashi, N., Kobayashi, Y. Tags: STKE Research Articles Source Type: news

Boston Scientific, Medtronic join $30m SetPoint Medical Series D
SetPoint Medical said today it raised $30 million in a Series D equity financing round with funds slated to support continued development of its bioelectronic therapy for treating chronic inflammatory diseases. Funding in the round came from existing investors including NEA, Morgenthaler, Medtronic (NYSE:MDT), Boston Scientific (NYSE:BSX), Topspin, Action Potential Venture Capital, the Valencia, Calif.-based company said. “We are grateful for the strong support from our investors who are aligned with our vision to commercialize life-changing bioelectronic medicines for patients with debilitating inflam...
Source: Mass Device - August 28, 2017 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Neuromodulation/Neurostimulation Boston Scientific Medtronic SetPoint Medical Source Type: news

Ibuprofen associated with blood pressure rise in arthritis patients at cardiovascular risk
(European Society of Cardiology) Ibuprofen is associated with increased blood pressure and hypertension compared to celecoxib in patients with osteoarthritis or rheumatoid arthritis and increased risk of cardiovascular disease, according to late-breaking results from the PRECISION-ABPM study presented today in a Hot Line Session at ESC Congress and published in EHJ. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 28, 2017 Category: International Medicine & Public Health Source Type: news

FDA Approves Second Humira Biosimilar, Cyltezo FDA Approves Second Humira Biosimilar, Cyltezo
Adalimumab-adbm Cyltezo, from Boehringer Ingelheim, is approved for multiple indications including treatment of adults with moderate-to-severe active rheumatoid arthritis.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 25, 2017 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

Lupus Leads Inflammatory Disorders in Cardiometabolic Risk
Study authors called for early screening and regular monitoring risk in patients with these disorders. (Source: CancerNetwork)
Source: CancerNetwork - August 24, 2017 Category: Cancer & Oncology Authors: Leo Robert Tags: Lupus Rheumatoid Arthritis Rheumatic Diseases Source Type: news

Oral Contraceptives May Cut Rheumatoid Arthritis Risk Oral Contraceptives May Cut Rheumatoid Arthritis Risk
Current oral contraceptive users had a 15% reduction in the risk of developing rheumatoid arthritis (RA); breast-feeding had no significant effect on RA risk, a Swedish study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 23, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Oral Contraceptives Tied to Lower Rheumatoid Arthritis Risk
Women who took oral contraceptives were less likely to develop rheumatoid arthritis. (Source: NYT Health)
Source: NYT Health - August 23, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Birth Control and Family Planning Rheumatoid Arthritis Women and Girls Breastfeeding Source Type: news

Contraceptive pill 'may lower risk of rheumatoid arthritis in women'
Women who regularly use oral contraceptives may be at a lower risk of developing rheumatoidarthritis. This is according to a new study led by the Karolinska Institutet in Sweden and published in the British Medical Journal, which adds to the body of evidence suggesting that hormonal and reproductive factors may explain why women are generally at greater risk of developingrheumatoid arthritis than men. The study findings For this study, data was collated from the Swedish Epidemiological Investigation of Rheumatoid Arthritis on 2,809 women who had been diagnosed with rheumatoid arthritis and 5,312 women without the disease. ...
Source: Arthritis Research UK - August 21, 2017 Category: Rheumatology Source Type: news

New research shines spotlight on mental health and arthritis
Around a third of the 400,000 people in the UK with rheumatoid arthritis also experience mental health issues. Statistics like these clearly show arthritis does not just affect people’s physical health. Without the right treatment and support the pain and fatigue of rheumatoid arthritis can take its toll on our minds, as well as our bodies.We want this to change and for the mental health issues associated with arthritis to be taken seriously, recognised early and treated effectively. We've forged a new partnership with mental health research charityMQ: Transforming Mental Health to support vital research in this...
Source: Arthritis Research UK - August 21, 2017 Category: Rheumatology Source Type: news

The true impact of arthritis
You'll know all too well the impact arthritis has on your own life. Perhaps you also think about how your arthritis affects your loved ones or your employer, but the impact doesn’t stop there. With 10 million people in the UK living with arthritis, each with friends and family, many with work colleagues and employers and all supported by a team of healthcare professionals, the ripple effect of arthritis touches every person in our society, either directly or indirectly.To support our campaign, we've gathered evidence to reveal the extent of the hidden impact of arthritis on our society, published in a new report...
Source: Arthritis Research UK - August 21, 2017 Category: Rheumatology Source Type: news

The nation's #jointproblem: Arthritis will cause 25.9 million lost working days costing £3.43 billion by 2030
Arthritis Research UK, the UK’s leading arthritis charity, is today launching a major nationwide campaign to reveal the true impact of arthritis across society. The campaign will highlight that, either directly or indirectly, arthritis impacts everyone in the UK. The campaign will also highlight that there are over 10 million people living with arthritis and the condition can cause high levels of daily pain and fatigue.As part of the launch, Arthritis Research UK is releasing The Nation’s Joint Problem report which reveals the current and future impact of two major forms of the condition, osteoarthritis (O...
Source: Arthritis Research UK - August 20, 2017 Category: Rheumatology Source Type: news

Why a typically blas é event is a big deal for this Peninsula biotech
After ups and downs for the onetime potential rheumatoid arthritis drug, the FDA's acceptance of a new-drug application is a big deal, pointing toward an April approval decision for the drug for a bleeding disorder. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 19, 2017 Category: Biotechnology Authors: Ron Leuty Source Type: news

Why a typically blas é event is a big deal for this Peninsula biotech
After ups and downs for the onetime potential rheumatoid arthritis drug, the FDA's acceptance of a new-drug application is a big deal, pointing toward an April approval decision for the drug for a bleeding disorder. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - August 18, 2017 Category: American Health Authors: Ron Leuty Source Type: news

Switching From Bisphosphonates to Teriparatide May Improve BMD in Women With RA Switching From Bisphosphonates to Teriparatide May Improve BMD in Women With RA
Switching women with rheumatoid arthritis (RA) from oral bisphosphonates to teriparatide increases bone mineral density (BMD) and trabecular bone score, according to a new report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 18, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Medical News Today: Rheumatoid arthritis: Birth control pill tied to reduced risk
A large Swedish study has found that women who had used contraceptive pills had less risk of developing rheumatoid arthritis than women who had not. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 18, 2017 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Arthritis diet: The SIX foods to avoid if you suffer painful symptoms
RHEUMATOID arthritis is a long-term condition that causes pain, swelling and stiffness in the joints and mainly affects the hands feet and wrists. (Source: Daily Express - Health)
Source: Daily Express - Health - August 18, 2017 Category: Consumer Health News Source Type: news

Contraceptive pill linked to reduced risk of rheumatoid arthritis
Taking oral contraceptive for seven or more consecutive years is linked to a 19% lower risk of developing rheumatoid arthritis (RA), according to researchers. (Source: GP Online News)
Source: GP Online News - August 18, 2017 Category: Primary Care Tags: 10.1 Women's Health Source Type: news

Taking the pill for seven years could reduce arthritis risk by 19%
No protective effect found from breastfeeding Related items fromOnMedica Rheumatoid arthritis Breastfeeding may halve rheumatoid arthritis risk Obese women on the pill more likely to have rare stroke Contraceptive pill appears to protect from cancers for up to 30 years Oral contraceptive pill impacts on wellbeing (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 18, 2017 Category: UK Health Source Type: news

Lab tests show molecule appears to spur cell death in tumors, inflammation
(Duke University Medical Center) A drug-like molecule developed by Duke Health researchers appears to intercede in an inflammatory response that is at the center of a variety of diseases, including some cancers, rheumatoid arthritis and Crohn's disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 17, 2017 Category: Cancer & Oncology Source Type: news

Some jobs tied to higher risk of rheumatoid arthritis
(Reuters Health) - Workers exposed to airborne toxins may have an elevated risk of developing rheumatoid arthritis, an immune system disorder that causes debilitating swelling and pain in the joints, a Swedish study suggests. (Source: Reuters: Health)
Source: Reuters: Health - August 15, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Does Lipitor Help Rheumatoid Arthritis?
Title: Does Lipitor Help Rheumatoid Arthritis?Category: Doctor's& Expert's views on SymptomsCreated: 8/15/2017 12:00:00 AMLast Editorial Review: 8/15/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 15, 2017 Category: Rheumatology Source Type: news

Female HCAs at 'slightly higher risk of rheumatoid arthritis'
Being a healthcare assistant may put women at slightly higher risk of developing rheumatoid arthritis than the rest of the population, including registered nurses, a study has suggested. (Source: Nursing Times)
Source: Nursing Times - August 11, 2017 Category: Nursing Source Type: news

Certain Jobs Linked to Raised Risk of Rheumatoid Arthritis
Title: Certain Jobs Linked to Raised Risk of Rheumatoid ArthritisCategory: Health NewsCreated: 8/10/2017 12:00:00 AMLast Editorial Review: 8/11/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 11, 2017 Category: Rheumatology Source Type: news

Scientists make critical insights into T-cell development
(Monash University) Mutations in the gene encoding the enzyme protein tyrosine phosphatase N2 (PTPN2) have been associated with the development of autoimmune disease including Type 1 diabetes, Crohn's Disease and rheumatoid arthritis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 11, 2017 Category: International Medicine & Public Health Source Type: news

Certain jobs linked to raised risk of rheumatoid arthritis
Rheumatoid arthritis appears to be more common among people in certain types of jobs, researchers suggest. (Source: Health News - UPI.com)
Source: Health News - UPI.com - August 11, 2017 Category: Consumer Health News Source Type: news

Rheumatoid arthritis risk 'may be elevated for people in certain jobs'
This study, published in the medical journal Arthritis Research& Care, assessed data from 3,522 Swedish individuals with rheumatoid arthritis and 5,580 control subjects, including information on environmental, genetic and immunological factors between 1996 and 2014. Male workers in the manufacturing sector were shown to have a higher risk of developing rheumatoid arthritis than those working in professional, administrative and technical roles, with electrical and electronics workers and material handling operators experiencing a twofold increased risk, while bricklayers and concrete workers were three times more likely...
Source: Arthritis Research UK - August 10, 2017 Category: Rheumatology Source Type: news

Occupational Exposures Increase Rheumatoid Arthritis Risk Occupational Exposures Increase Rheumatoid Arthritis Risk
Workers in certain occupations were at increased risk of developing arthritis, a population-based cohort study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 10, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Certain Jobs Linked to Raised Risk of Rheumatoid Arthritis
Risk was doubled among men who did electrical work, and tripled among bricklayers, study finds Source: HealthDay Related MedlinePlus Pages: Occupational Health, Rheumatoid Arthritis (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 10, 2017 Category: Consumer Health News Source Type: news

Certain Jobs Linked to Raised Risk of Rheumatoid Arthritis
THURSDAY, Aug. 10, 2017 -- Rheumatoid arthritis, a painful disease in which a person's immune system attacks the joints, appears to be more common among people in certain types of jobs, researchers suggest. The findings " indicate that work-related... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 10, 2017 Category: General Medicine Source Type: news

Arthritis warning: THIS common medication could be linked to deadly liver failure
ARTHRITIS causes symptoms including painful joints and stiffness. One type, rheumatoid arthritis, is often treated with medications that reduce discomfort - but the side effects of the drug methotrexate, can include liver failure. (Source: Daily Express - Health)
Source: Daily Express - Health - August 10, 2017 Category: Consumer Health News Source Type: news

Certain occupations linked to an increased risk of rheumatoid arthritis
(Wiley) New research indicates that certain occupations may put workers at an elevated risk of developing rheumatoid arthritis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 10, 2017 Category: International Medicine & Public Health Source Type: news

Certain occupations linked to increased risk of rheumatoid arthritis
Male manufacturing workers, bricklayers and concrete workers are at particularly high risk Related items fromOnMedica Fibre-rich diet linked to lowered risk of painful knee osteoarthritis Fibre-rich diet linked to lowered risk of painful knee osteoarthritis Chondroitin sulfate as good as widely used anti-inflammatory for knee osteoarthritis Rheumatoid arthritis Obesity may skew results of rheumatoid arthritis blood tests in women (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 10, 2017 Category: UK Health Source Type: news