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Lilly and Incyte Announce Submission of NDA to FDA for Oral Once-Daily Baricitinib for Treatment of Moderate-to-Severe Rheumatoid Arthritis
INDIANAPOLIS, Jan. 19, 2016 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) and Incyte Corporation (NASDAQ: INCY) today announced that Lilly has submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) for the approval... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - January 19, 2016 Category: Drugs & Pharmacology Source Type: news

New biosimilar version of etanercept approved in Europe
An affordable new treatment for various types of arthritis is to be made available in Europe following the approval of the drug Benepali.The new biosimilar version of the anti-TNF therapy etanercept has been granted marketing authorisation in the EU for the treatment of adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, non-radiographic axial spondyloarthritis and plaque psoriasis.Developed by Samsung Bioepis, the drug is the first etanercept biosimilar to be based on the licensed product Enbrel, and will become the first subcutaneous anti-TNF biosimilar to be launched in Europe.Biosimilars are biolo...
Source: Arthritis Research UK - January 19, 2016 Category: Rheumatology Source Type: news

Textile dust exposure 'could increase rheumatoid arthritis risk'
A new study has indicated that people who work with frequent exposure to textile dust could be at an elevated risk of developing rheumatoid arthritis. Led by the Institute for Medical Research in Malaysia, in association with Sweden's Karolinska Institutet, the research looked at data from 910 Malaysian women who had been diagnosed with early-stage rheumatoid arthritis, compared with data from 910 women of similar age without the disease. The patients were asked if they had ever worked in the textile industry and been exposed to other chemicals and silica dust, factors associated with a heightened risk of rheumatoid arth...
Source: Arthritis Research UK - January 19, 2016 Category: Rheumatology Source Type: news

Predicting and Preventing the Development of RAPredicting and Preventing the Development of RA
Can we predict and prevent the development of rheumatoid arthritis? Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 18, 2016 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Samsung Gets European Approval for Enbrel Copy
Samsung Group said it has won approval from regulators to sell a near-replica of the blockbuster rheumatoid arthritis drug Enbrel in Europe. (Source: WSJ.com: Health)
Source: WSJ.com: Health - January 17, 2016 Category: Pharmaceuticals Tags: PAID Source Type: news

1 Person Left Brain Dead After Clinical Trial Of Experimental Medicine In France (UPDATE)
PARIS, Jan 15 (Reuters) - One person has been left brain dead and five others have been hospitalized after taking part in a clinical trial in France of an experimental drug made by Portuguese drug company Bial, French Health Minister Marisol Touraine said on Friday. In total, 90 people have taken part in the trial, taking some dosage of the drug aimed at tackling mood and anxiety issues, as well as movement coordination disorders linked to neurological issues, Touraine said. The six men aged 28 to 49 had been in good health until taking the oral medication at the Biotrial private facility that specializes in clinical trial...
Source: Science - The Huffington Post - January 15, 2016 Category: Science Source Type: news

Occupational textile dust exposure linked to rheumatoid arthritis
Occupational exposure to textile dust is associated with a more than doubling in the risk of developing rheumatoid arthritis, finds new research. And it is also linked to a heightened risk of genetic susceptibility to the risk of developing antibodies to rheumatoid arthritis, known as ACPA, which hasten progression of the disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 15, 2016 Category: Science Source Type: news

Medical News Today: Ovarian cancer with BRCA1 mutation may be treatable with arthritis drug
Lab tests show that auranofin - normally used to treat rheumatoid arthritis - can cut survival of ovarian cancer cells that have low levels of the DNA repair protein BRCA1. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 11, 2016 Category: Consumer Health News Tags: Ovarian Cancer Source Type: news

Arthritis drug could also help combat ovarian cancer
ConclusionThere is an ongoing need for the development of new and more effective treatments for ovarian cancer, a cancer that is notoriously detected at a late stage and often has a poor outlook as a result. Women with mutations in the DNA repair gene, BRCA1, are known to have an increased risk of developing ovarian cancer. This laboratory study investigated the potential of the drug auranofin, which is approved in the US for the treatment of rheumatoid arthritis. The researchers found auranofin had superior cancer-killing properties in ovarian cancer cells lacking BRCA1. It seems depletion of BRCA1 makes the cancer cells ...
Source: NHS News Feed - January 11, 2016 Category: Consumer Health News Tags: Cancer Medication Source Type: news

Arthritis drug could offer hope to millions with the 'Angelina Jolie gene'
Plymouth University scientists found that auranofin, a drug typically used to treat rheumatoid arthritis, can help cut survival of cancerous ovarian cells in women with BRCA1 mutations, by 37 per cent. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2016 Category: Consumer Health News Source Type: news

What Are the Best and Worst Supplements and Herbs for Rheumatoid Arthritis (RA)?
Some supplements are good for rheumatoid arthritis (RA). Some are dangerous. WebMD explains which supplements and herbs may help relieve rheumatoid arthritis symptoms and which ones you should never take. (Source: WebMD Health)
Source: WebMD Health - January 7, 2016 Category: Consumer Health News Source Type: news

Expert Advice on How to Treat Rheumatoid Arthritis
An expert tells WebMD how to manage and treat rheumatoid arthritis. (Source: WebMD Health)
Source: WebMD Health - January 7, 2016 Category: Consumer Health News Source Type: news

Assessing the Inhibitory Activity of Oligonucleotides on TLR7 Sensing
Aberrant sensing of self-nucleic acids by Toll-like receptor (TLR) 7, 8, or 9 is associated with several autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriasis, or systemic sclerosis. In recent years, several classes of synthetic oligonucleotides have been shown to antagonize sensing of immunostimulatory nucleic acids by TLR7/8/9, indicating that these molecules could have therapeutic applications in such autoimmune diseases. Conversely, synthetic oligonucleotides used in therapeutic technologies such as antisense and microRNA inhibitors also have the potential to inhibit TLR7/8...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Investigating the Role of Toll-Like Receptors in Models of Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation leading to tissue destruction and progressive loss of joint function. Here we describe two methods that can be used to assess the contribution of toll-like receptors (TLRs), and their potential ligands, to RA pathogenesis. We focus on the antigen-induced model of murine arthritis and human synovial tissue explant models. Both enable detection of TLR, and TLR ligand, expression, as well as investigation of the effect of inhibition of these molecules. Each offers a unique insight into disease; with murine models allowi...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Insider’s guide to care: Doctors and dogs
Olivia and Dayton Olivia Burgess knows every nook and cranny of Boston Children’s Hospital. The 13-year-old and her parents have traveled from their home in Bermuda to Boston since Olivia was three years old for ongoing treatments for systemic onset juvenile rheumatoid (idiopathic) arthritis and pediatric lupus. “The unpredictable and severe nature of Olivia’s condition and the frequent travel required for medical treatment can be stressful at times,” says her mother Traci. Olivia sees providers in multiple departments: cardiology, nephrology, pulmonology, dermatology, neurology, gastroenterology an...
Source: Thrive, Children's Hospital Boston - January 4, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Fatma Dedeoglu juvenile rheumatoid arthritis Marybeth Son Pawprints Program pediatric lupus rheumatology program Robert Geggel Sitaram Emani Source Type: news

Eat fish to LOWER arthritis risk
CONSUMING more omega-3 fatty acids could lower the risk of developing rheumatoid arthritis , according to new research. (Source: Daily Express - Health)
Source: Daily Express - Health - December 28, 2015 Category: Consumer Health News Source Type: news

Medical News Today: Omega-3 helps ward off rheumatoid arthritis
People who are predisposed to develop RA are less likely to develop it if they have been taking omega-3 fish oil and supplements, say researchers. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 27, 2015 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

How Does RA Affect Your Everyday Life?
Rheumatoid Arthritis can impact your life. WebMD helps you manage with these simple tips. (Source: WebMD Health)
Source: WebMD Health - December 23, 2015 Category: Consumer Health News Source Type: news

Rheumatoid Arthritis and Sex
Do you know how RA can affect your sex life? WebMD has the answers. (Source: WebMD Health)
Source: WebMD Health - December 23, 2015 Category: Consumer Health News Source Type: news

Rheumatoid Arthritis and Lymphoma
It’s your arthritis, not your drugs, which slightly raise your risk of lymphoma. WebMD explains why it happens. (Source: WebMD Health)
Source: WebMD Health - December 23, 2015 Category: Consumer Health News Source Type: news

Smoking, Drinking, and Rheumatoid Arthritis
How do smoking and drinking affect rheumatoid arthritis? WebMD explains. (Source: WebMD Health)
Source: WebMD Health - December 22, 2015 Category: Consumer Health News Source Type: news

Yoga Provides Benefits in Knee Osteoarthritis, Rheumatoid Arthritis
Source: Lippincott’s Bone and Joint Newsletter - December 17, 2015 Category: Orthopaedics Tags: Perspective Source Type: news

Golimumab proven effective as a rheumatoid arthritis therapy
This study builds upon the pioneering work funded by Arthritis Research UK into the initial development of anti-TNF therapies in rheumatoid arthritis. The finding that golimumab is effective provides those treating the 400,000 people with another weapon in the fight to relieve their daily pain and disability." (Source: Arthritis Research UK)
Source: Arthritis Research UK - December 17, 2015 Category: Rheumatology Source Type: news

Blood test could predict rheumatoid arthritis risk
Scientists have found a marker that can indicate your likelihood of suffering from rheumatoid arthritis (RA) up to 16 years before the condition takes effect. A team from the Kennedy Institute of Rheumatology at Oxford University found that a blood test that looks for antibodies could reliably show those who will contract the condition. The research, which we funded, could lead to early detection of rheumatoid arthritis, a disease which affects over 400,000 people in the UK. Rhematoid arthritis occurs when proteins are altered during inflammation in a process called citrullination. It means the altered immune response can ...
Source: Arthritis Research UK - December 14, 2015 Category: Rheumatology Source Type: news

Biomarker-based tests 'can help predict rheumatoid arthritis relapses'
This study shows that biomarkers may also be useful in identifying patients in whom treatment can safely be reduced or withdrawn." (Source: Arthritis Research UK)
Source: Arthritis Research UK - December 14, 2015 Category: Rheumatology Source Type: news

New blood test promises to give up to 16 years' warning of arthritis 
Rheumatoid arthritis affects some 400,000 Britons, and drug treatments work best when they are given early. Wrists, toes and fingers are particularly susceptible to the disease. (Source: the Mail online | Health)
Source: the Mail online | Health - December 11, 2015 Category: Consumer Health News Source Type: news

Arthritis cure could be developed after discovery of test which predicts condition 16 years before symptoms show
Rheumatoid arthritis (RA) occurs when a protein called tenascin-C is altered during inflammation (Source: Telegraph Health)
Source: Telegraph Health - December 10, 2015 Category: Consumer Health News Tags: arthritis rheumatoid arthritis tenascin-C Source Type: news

Blood test may predict risk for rheumatoid arthritis
Stephen FellerOXFORD, England, Dec. 10 (UPI) -- Scientists found testing blood for an altered protein present in the joints of rheumatoid arthritis patients can indicate the condition years before it appears. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 10, 2015 Category: Consumer Health News Source Type: news

Arthritis predicted 16 years before disease takes hold using new test
Early detection key as early treatment more effective (Source: Telegraph Health)
Source: Telegraph Health - December 10, 2015 Category: Consumer Health News Tags: arthritis rheumatoid arthritis tenascin-C Source Type: news

RHEUMATOID ARTHRITIS NOSODE (Adenosinum Triphosphoricum Dinatrum, Malic Acid, Natrum Oxalaceticum, Oroticum Acidum, Riboflavinum, Apiolum, Cinnamic Acid, Dhea (Dehydroepiandrosterone), Streptococcus Viridans, Borrelia Burgdorferi Nosode, Brucella Abortus, Calcarea Carbonica, Campylobacter Jejuni, Chlamydia Trachomatis, Klebsiella Pheumoniae, Mycoplasma Pneumoniae, Yersinia Enterocolitica, Pneumococcinum, Streptococcus Agalactiae, Enterococcus Faecalis, Streptococcus Mutans, Salmonella Enteritidis, Dysentery Bacillus, Shigella Sonnei) Liquid [Deseret Biologicals, Inc.]
Updated Date: Dec 9, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 9, 2015 Category: Drugs & Pharmacology Source Type: news

12 Early Symptoms and Signs of Rheumatoid Arthritis (RA)
Title: 12 Early Symptoms and Signs of Rheumatoid Arthritis (RA)Category: Diseases and ConditionsCreated: 6/24/2013 12:00:00 AMLast Editorial Review: 12/7/2015 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - December 7, 2015 Category: Rheumatology Source Type: news

Rheumatoid arthritis: Can it affect the lungs?
(Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - December 7, 2015 Category: Consumer Health News Source Type: news

Two Valuable Treatment Advances in Rheumatoid Arthritis Two Valuable Treatment Advances in Rheumatoid Arthritis
Drs Jonathan Kay and Ronald van Vollenhoven discuss how biomarkers are helping guide therapy in rheumatoid arthritis. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 25, 2015 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Fertility in Women With Rheumatoid ArthritisFertility in Women With Rheumatoid Arthritis
Why do some women with rheumatoid arthritis experience difficulties conceiving? Annals of the Rheumatic Diseases (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 25, 2015 Category: Pathology Tags: Rheumatology Journal Article Source Type: news

First Enbrel Biosimilar Recommended for Approval in EuropeFirst Enbrel Biosimilar Recommended for Approval in Europe
The EMA has recommended Benepali, an etanercept biosimilar for the treatment of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and plaque psoriasis. International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 20, 2015 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

Medical News Today: C-EARLY: certolizumab pegol effective in early rheumatoid arthritis
A study presented at the American College of Rheumatology Annual Meeting suggests certolizumab pegol is beneficial for patients with early rheumatoid arthritis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2015 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Switching Targets Best in RA Patients Who Fail Anti-TNFSwitching Targets Best in RA Patients Who Fail Anti-TNF
Changing the class of biologics is an effective strategy for most patients with rheumatoid arthritis (RA) who don't respond to their first anti-tumor necrosis factor (TNF) agent, new research shows. Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 19, 2015 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

Europe could recommend second biosimilar arthritis drug this week
LONDON (Reuters) - Europe could soon gain a second biosimilar antibody drug for rheumatoid arthritis and other autoimmune diseases, with regulators due to decide by Friday whether to recommend South Korean company Samsung Bioepis's copy of Enbrel. (Source: Reuters: Health)
Source: Reuters: Health - November 18, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

New Clinical Trial to Study Impact of Rheumatoid Arthritis Therapies on Cardiovascular Disease
NIH Grants $8.56 Million to Brigham and Women’s Hospital and Columbia University Medical Center for Clinical Trial (Source: BWH for Journalists)
Source: BWH for Journalists - November 18, 2015 Category: Research Source Type: news

New Clinical Trial to Study Impact of Rheumatoid Arthritis Therapies on Cardiovascular Disease
NIH Grants $8.56 Million to Brigham and Women’s Hospital and Columbia University Medical Center for Clinical Trial (Source: BWH News)
Source: BWH News - November 18, 2015 Category: Hospital Management Source Type: news

Medtech approvals: FDA releases September 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in September 2015: Summary of PMA Originals & Supplements Approved Originals: 4 Supplements: 53 Summary of PMA Originals Under Review Total Under Review: 55 Total Active: 31 Total On Hold: 24 Summary of PMA Supplements Under Review Total Under Review: 611 Total Active: 461 Total On Hold: 150 Summary of All PMA Submissions Originals: 3 Supplements: 84 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 53 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 127.6 FDA Ti...
Source: Mass Device - November 16, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news

Association between serum vitamin D level and history of falls in elderly Japanese patients with rheumatoid arthritis - Ochi K, Furuya T, Ikari K, Taniguchi A, Yamanaka H, Momohara S.
[Abstract unavailable] Language: en... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 15, 2015 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

Filgotinib Shows Potential in Rheumatoid ArthritisFilgotinib Shows Potential in Rheumatoid Arthritis
Response to the Janus kinase 1 inhibitor was good in patients with rheumatoid arthritis who have highly active disease despite methotrexate therapy, new research showed. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 15, 2015 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Treat to Target Achieves Remission in Rheumatoid ArthritisTreat to Target Achieves Remission in Rheumatoid Arthritis
Patients are more likely to achieve remission when that is the goal of treatment, new research confirms. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 12, 2015 Category: Consumer Health News Tags: Rheumatology News Source Type: news

RA Patients With Fibromyalgia See Functional Impairment
(MedPage Today) -- Chronic pain assessment may be beneficial in rheumatoid arthritis (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - November 11, 2015 Category: Geriatrics Source Type: news

Medical News Today: Olokizumab shows potential for tough-to-treat rheumatoid arthritis
Research presented at the 2015 American College of Rheumatology Annual Meeting shows long-term benefits of using olokizumab to treat RA. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2015 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Heart Disease Deaths Drop for Those With Rheumatoid Arthritis: Study
Title: Heart Disease Deaths Drop for Those With Rheumatoid Arthritis: StudyCategory: Health NewsCreated: 11/9/2015 12:00:00 AMLast Editorial Review: 11/10/2015 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 10, 2015 Category: Rheumatology Source Type: news

Baricitinib Tops Methotrexate in Early Rheumatoid ArthritisBaricitinib Tops Methotrexate in Early Rheumatoid Arthritis
Baricitinib, alone or in combination with methotrexate, works better than methotrexate alone in patients with early rheumatoid arthritis, according to results from the phase 3 RA-BEGIN trial. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 9, 2015 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Studies Explore Link Between Diet, Rheumatoid Arthritis
Title: Studies Explore Link Between Diet, Rheumatoid ArthritisCategory: Health NewsCreated: 11/8/2015 12:00:00 AMLast Editorial Review: 11/9/2015 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 9, 2015 Category: Rheumatology Source Type: news

Heart Disease Deaths Declining Among Those With Rheumatoid Arthritis: Study
Title: Heart Disease Deaths Declining Among Those With Rheumatoid Arthritis: StudyCategory: Health NewsCreated: 11/8/2015 12:00:00 AMLast Editorial Review: 11/9/2015 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 9, 2015 Category: Rheumatology Source Type: news