Casting the Net Wide: the Role of Neutrophils in Chronic Diseases
This is a rescheduled Mider Lecture. Speaker Mariana Kaplan, NIH NIAMS, focuses on identifying mechanisms of immune dysregulation, organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases.For more information go tohttps://oir.nih.gov/walsAir date: 6/9/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Protective and Pathogenic B Cell Responses: COVID-19 and Autoimmunity
Dr. Sanz's research interest is in understanding how the immune system goes awry in autoimmune diseases and ends up attacking our own tissues rather than concentrating on fighting infections. In particular, he is very interested in understanding the roles played in autoimmune diseases by B cells and their effector progeny, the plasma cells responsible for producing the autoantibodies that in many cases cause the disease. His research concentrates on systemic lupus erythematosus, but he is also investigating other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis and type 1 diabetes. His work also has app...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

2019 Demystifying Medicine Lecture- Autoimmunity: Basic and Clinical Advances and Challenges
Please join us for the next Demystifying Medicine lecture, " Autoimmunity: Basic and Clinical Advances and Challenges, " by Ronald Germain, M.D., Ph.D. (NIAID) and James Katz, M.D. (NIAMS) on April 23 from 4:00 p.m. to 5:30 p.m. in the Building 50 conference room, first floor. CME credit is available. Autoimmunity refers to a system of immune responses gone awry, tantamount to an attack against the body's own healthy cells and tissues with painful and often fatal consequences. This enemy within manifests itself in myriad ways, from targeted attacks (e.g., rheumatoid arthritis leading to debilitating joint damage) to multi...
Source: Videocast - All Events - April 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Acting as white blood cell decoys, " nanosponges " alleviate and prevent rheumatoid arthritis in mouse
Engineers at the University of California, San Diego, have developed "nanosponges" that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 7, 2019 Category: Science Source Type: video

William F. C. Rigby, MD - Improving Outcomes for Patients With Refractory Rheumatoid Arthritis: The Role of JAK Inhibitors
Improving Outcomes for Patients With Refractory Rheumatoid Arthritis: The Role of JAK Inhibitors (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - October 12, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video

B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

A Bacterial Cause of Rheumatoid Arthritis
NIDCR Clinical Research Fellowship Grand Rounds Understanding the mechanisms which initiate immune responses to autoantigens is of high priority. Significant data implicates mucosal surfaces, specifically the periodontium, the gut, and the lungs, as sites of disease initiation in rheumatoid arthritis (RA), an autoimmune disease characterized by autoantibodies to citrullinated proteins. In recent studies, we identified Aggregatibacter actinomycetemcomitans (Aa), a pathogen associated with chronic and aggressive periodontitis, as a candidate bacterial trigger of autoimmunity in RA. Aa secretes a toxin, leukotoxin A (LtxA), w...
Source: Videocast - All Events - November 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video

William F.C. Rigby, MD - JAK Inhibitors in Rheumatoid Arthritis: Aligning Pathophysiology, Treatment Advances, and Patient Preference Into a Personalized Approach to Care for Improved Outcomes
JAK Inhibitors in Rheumatoid Arthritis: Aligning Pathophysiology, Treatment Advances, and Patient Preference Into a Personalized Approach to Care for Improved Outcomes (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - October 11, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video

The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video

Alan J. Kivitz, MD, CPI - Addressing Unmet Needs in Rheumatoid Arthritis Through Novel Treatment Options and Enhanced Physician –Patient Collaboration
Addressing Unmet Needs in Rheumatoid Arthritis Through Novel Treatment Options and Enhanced Physician–Patient Collaboration (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - September 6, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video

NETting the web in systemic autoimmunity
Immunology Interest Group Seminar Series Mariana Kaplan, M.D. is Senior Investigator and Chief of the Systemic Autoimmunity Branch at NIAMS/NIH. Prior to her appointment, she was Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years, and an acti...
Source: Videocast - All Events - June 19, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video

Roy Fleischmann, MD, MACR - Novel Options and Patient Perspectives in Rheumatoid Arthritis: Individualizing Care for Therapeutic Success
Novel Options and Patient Perspectives in Rheumatoid Arthritis: Individualizing Care for Therapeutic Success (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - April 7, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video

The microbiota as instructor and arbiter of immune responses in health and disease
NIH Director's Wednesday Afternoon Lecture Series Dr. Littman ’ s laboratory applies molecular and genetics tools to study how T lymphocytes develop and participate in inflammation and how HIV interacts with the host innate immune system. Dr. Littman isolated the genes for the CD4 and CD8 co-receptors and determined how their expression is regulated and their signaling influences selection of helper and cytotoxic cells. His group discovered that the nuclear receptor ROR  t regulates differentiation of Th17 cells and lymphoid tissue inducer cells and that it can be targeted for autoimmune disease therapy. He and his co...
Source: Videocast - All Events - February 6, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video