Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ASC Specks as a Sizable Contribution to Chronic Inflammation
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - April 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Towards Control of Inflammation as an Important Goal in the Treatment of Aging
Today I'll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation w...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Discovering What's Behind Older Adults' Fear of Falling May Encourage More Activity
Photo credit Jonas Kakaroto Dear Carol: My mother lives with pain from rheumatoid arthritis and she’s also experiencing early symptoms of Alzheimer’s. She’s used a cane for years and was confident with these aids but recently she’s become terrified of falling. I bought her a walker, and she says that makes her feel more stable. Still, she’s fearful when she moves around so she’s become extraordinarily sedentary.  I can understand caution, but I’m afraid that if she avoids all activity, her health will decline even faster. She lives with me and there can be friction when I make suggestions. Is ther...
Source: Minding Our Elders - April 3, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Whither Covid?
I recommend this Twitter thread by John Burn-Murdoch, as most Americans and their political leaders have apparently decided that the pandemic is over. It isn ' t, although here in the U.S. we are in a better place than we were a year ago. In a nutshell, new cases and hospitalizations are rising in much of the world, including much of Europe. This isn ' t so much because of loosened mitigation measures, but because of the emergence of a new variant, Omicron B.A2 which is evidently even more contagious than the original Omicron and perhaps a bit better at getting around existing immunity. It ' s just starting to show up...
Source: Stayin' Alive - March 18, 2022 Category: American Health Source Type: blogs

Notes and Cards Can Help People Living with Dementia Remember Visits
Photo credit Fred Kearney Dear Carol:  My father moved into assisted living several years ago because of his rheumatoid arthritis. A few months back, he was diagnosed with Alzheimer’s so now he’s been moved into their memory care wing. Both of Dad’s parents developed Alzheimer’s so he’s become quite depressed thinking he’ll follow the same path they did. Unfortunately, he seems to be losing ground with his memory very quickly so even though I drive into town every weekend to see him he forgets my visits. He can still read though he can’t remember well enough to read books or articles. Do you think it wo...
Source: Minding Our Elders - February 6, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Top 10 Digital Health News Of 2021
From the approval of a new prescription VR treatment to renewed privacy concerns, 2021 has been full of digital health developments. Indeed, some news might have gone under the radar or might require a quick refresher; so we’re wrapping up 2021 with a round-up of 10 of the most important digital health news of this year. 1. FDA-approved prescription VR treatment for chronic back pain In mid-November, the FDA authorised a virtual reality (VR) system as a prescription treatment for chronic back pain. Called EaseVRx, it combines cognitive behaviour therapy techniques and breathing exercises to help relax, distract...
Source: The Medical Futurist - December 16, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Covid-19 3D Printing Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones apple telehealth blood pressure A.I. 23andme news remote care 2021 Source Type: blogs

Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tips for Traveling with Mobility Limitations Along with Incontinence
Traveling with conditions like multiple sclerosis (MS) or rheumatoid arthritis (RA) can be challenging, particularly when mobility is a serious concern. Add incontinence to that - something that is quite common with MS - and the challenge increases. Yet, it can be done. It takes research and careful planning like this couple did but they made it work last summer. Start planning your trip for spring! Read more about traveling with extra challenges like incontinence on Egosancares blog: Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpos...
Source: Minding Our Elders - December 3, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Results from a Trial of the Senolytic Fisetin in a Single Individual with Autoimmunity
Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - November 30, 2021 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs

Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Perfect Gift!
This holiday season, we are all in search of the perfect gift. What is the one thing you truly desire for yourself and your family? Don’t you think we all want it? What if you were handed a beautifully wrapped box containing a miraculous tool that caused dramatic weight loss and good health without limiting calories or requiring exercise? What if this gift reduced appetite, shrunk belly fat, and dropped your dress size? What if that same gift freed you from acid reflux, heartburn, bowel urgency, and diarrhea, but also improved mood, increased energy, deepened sleep, and reduced or eliminated joint pain? And all of this m...
Source: Wheat Belly Blog - November 26, 2021 Category: Cardiology Authors: April Duval Tags: Open Source Type: blogs

Notes on the Recent Longevity Week in London
The yearly Longevity Week events in London are organized by Jim Mellon's network of allies, to promote the longevity industry and the concept of working towards therapies to treat aging as a medical condition. Sadly I could not attend this year, a combination of conflicting events in the US and it being too soon after conferences started up again post-COVID-19 to commit to international travel. Fortunately, one can still find a few notes on the proceedings online, and video of presentations will usually follow. This week was "Longevity Week" with numerous events organised in the UK on what we now call "geroscience...
Source: Fight Aging! - November 23, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming. In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs

Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs