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Research makes advances to treat osteoarthritis pain
For the 8.8 million people in the UK with osteoarthritis, research into new treatments to tackle osteoarthritis pain has the potential to dramatically improve quality of life. That’s why supporting innovative research in this area is one of our priorities, accounting for 25% of our research funding. We asked Dr Fiona Watt, consultant rheumatologist and senior clinical research fellow at our Centre for Osteoarthritis Pathogenesis at the Kennedy Institute of Rheumatology in Oxford, to share some of the latest developments: “Most of the patients who walk through the door to my clinic want to know how I can help t...
Source: Arthritis Research UK - March 10, 2016 Category: Rheumatology Source Type: news

Understanding pain – what it is and why we feel it
This issue we're looking at pain. Why? Because more than 1 in 6 people struggle with the pain of arthritis every day. Pain may be a common symptom experienced by millions, but it's a deeply complex issue.  Why do we feel pain? What is it about arthritis that causes pain? Why can two people have the same amount of deterioration in the joint but feel completely different levels of pain? These are just some of the questions you’ve asked about pain which our experts have helped us to answer. What is pain? Put simply, pain is a protective mechanism that alerts your brain when damage has occurred. It’s not jus...
Source: Arthritis Research UK - March 10, 2016 Category: Rheumatology Source Type: news

Serotonin deficiency implicated in rheumatoid arthritis
For the first time, serotonin (5-hydroxytryptamine, 5-HT) has been directly implicated in the pathophysiology of rheumatoid arthritis (RA). A new report shows that experimentally-induced RA in serotonin-deficient mice is worse than disease reported in controls and that some effects of RA can be reduced by serotonin or its agonists (compounds that activate serotonin receptors). (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 9, 2016 Category: Science Source Type: news

Serotonin deficiency implicated in rheumatoid arthritis
(Elsevier Health Sciences) For the first time, serotonin (5-hydroxytryptamine, 5-HT) has been directly implicated in the pathophysiology of rheumatoid arthritis (RA). A report in The American Journal of Pathology shows that experimentally-induced RA in serotonin-deficient mice is worse than disease reported in controls and that some effects of RA can be reduced by serotonin or its agonists (compounds that activate serotonin receptors). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2016 Category: Global & Universal Source Type: news

Rheumatoid Arthritis and Kidney Disease: Mayo Clinic Radio Health Minute
Rheumatoid arthritis is known for it's affects on the joints, but as we learn in this Mayo Clinic Radio Health Minute, the kidney can also be at risk. To listen, click the link below. Rheumatoid Arthritis and Kidney Disease (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 3, 2016 Category: Databases & Libraries Source Type: news

Taking vitamin D supplements may help winter-born babies
Taking vitamin D supplements during pregnancy may lead to stronger bones in babies born during the winter months, a new study published in The Lancet has shown. The research, which was part-funded by Arthritis Research UK, recruited more than 1,000 pregnant women to take part in a randomised, double-blind, placebo-controlled trial of vitamin D supplements in pregnancy. Increasing vitamin D in mothers Women were randomised to take either 1,000 units (25 microgrammes) of vitamin D every day or a matched placebo capsule from 14 week’s gestation until delivery of the baby. Results showed this dose of vitamin D was high...
Source: Arthritis Research UK - March 1, 2016 Category: Rheumatology Source Type: news

Rituximab Done: What's Next in Rheumatoid Arthritis?Rituximab Done: What's Next in Rheumatoid Arthritis?
Which biologic therapy is most effective after rituximab in rheumatoid arthritis patients? Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 29, 2016 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Autoimmune diseases gonna be defeated
(Lomonosov Moscow State University) An international team of scientists led by the Lomonosov Moscow State University group made a significant step in creating a new type of drug for treatment of autoimmune diseases, such as rheumatoid arthritis and Crohn's diseaase. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 29, 2016 Category: Infectious Diseases Source Type: news

Africa: Why Poor Rheumatoid Arthritis Sufferers in South Africa Have It Worse
[The Conversation Africa] In South Africa, studies show that patients suffering from rheumatoid arthritis can wait up to a year to be diagnosed and referred for therapy. In this time, their condition degenerates. Inflammation in their joints makes them painful, stiff and swollen. This leads to joint destruction and eventually disability before they have even been treated. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 26, 2016 Category: African Health Source Type: news

New report celebrates a decade of progress in chronic diseases
In the last 10 years, incredible progress has been made by the biopharmaceutical industry in the treatment of chronic diseases. With about half of all Americans, or 117 million people, living with one or more chronic health conditions, this innovation is more critical than ever. Patients with chronic diseases are frequent users of medical care, accounting for 81 percent of hospital admissions and 76 percent of physician visits. Treating these diseases is hugely expensive with 86 cents of every health care dollar spent in the United States going toward treating chronic illness, and the scope and severity of the problem is o...
Source: The Catalyst - February 25, 2016 Category: Pharmaceuticals Tags: Medicines in Development Innovation new medicines diabetes chronic disease HIV/AIDS Multiple Sclerosis Rheumatoid Arthritis Hepatitis C high cholesterol Source Type: news

FDA Clears Extended-Release Tofacitinib (Xeljanz XR) for RAFDA Clears Extended-Release Tofacitinib (Xeljanz XR) for RA
Xeljanz XR provides a once-daily oral option for patients with moderate to severe rheumatoid arthritis. FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - February 25, 2016 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

Pfizer receives FDA approval for Xeljanz XR to treat rheumatoid arthritis
Pfizer has received the US Food and Drug Administration (FDA) approval for its Xeljanz XR (tofacitinib citrate) extended-release tablets for the treatment of rheumatoid arthritis (RA). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 25, 2016 Category: Pharmaceuticals Source Type: news

Pfizer Announces FDA Approval of Xeljanz XR (tofacitinib citrate), the First and Only Once-Daily Oral JAK Inhibitor Treatment for Rheumatoid Arthritis
February 24, 2016 -- Pfizer Inc. (NYSE:PFE) announced today that the U.S. Food and Drug Administration (FDA) has approved Xeljanz XR (tofacitinib citrate) extended-release 11 mg tablets for the once-daily treatment of moderate to severe rheumatoid... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 24, 2016 Category: Drugs & Pharmacology Source Type: news

Influenza viruses can hide from the immune system
Influenza is able to mask itself, so that the virus is not initially detected by our immune system, a new study shows. The researchers behind the study hope that the discovery can be used to develop better treatment against influenza and chronic inflammation conditions such as rheumatoid arthritis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 23, 2016 Category: Science Source Type: news

Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist
Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector share...
Source: Science - The Huffington Post - February 19, 2016 Category: Science Source Type: news

Key mechanism explored to treat autoimmune diseases
A new study could change the way researchers understand and treat autoimmune diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 19, 2016 Category: Science Source Type: news

Periodontitis Linked With Childhood Arthritis (CME/CE)
(MedPage Today) -- Similar to the association in seropositive adult-onset rheumatoid arthritis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 19, 2016 Category: Primary Care Source Type: news

New biosimilar version of arthritis drug etanercept launches in UK
An affordable new therapy option for people with various forms of arthritis has been launched in the UK.Benepali is the first biosimilar version of the established anti-TNF therapy etanercept to be released in Britain, following its approval by the European Commission last month. Its availability is expected to expand access to anti-TNF therapy and ensure patients can be treated more cost-effectively.How Benepali works Biosimilars are a class of drugs that function as near-identical copies of established products that are already available on the market. They seek to replicate the effects and function of the reference prod...
Source: Arthritis Research UK - February 19, 2016 Category: Rheumatology Source Type: news

RheumNow: It Took Me 30 Years to Learn This About RA
(MedPage Today) -- Jack Cush, MD, shares insights into rheumatoid arthritis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 18, 2016 Category: Primary Care Source Type: news

Compound in green tea 'could help block effects of rheumatoid arthritis'
This study has opened the field of research into using EGCG for targeting TAK1 - an important signalling protein - through which proinflammatory cytokines transmit their signals to cause inflammation and tissue destruction in rheumatoid arthritis."The Arthritis Research UK view Richard Francis, head of research liaison and evaluation at Arthritis Research UK, said: "It is known that green tea contains antioxidants and this study shows that the specific EGCG molecule found in green tea can have anti-inflammatory effects."This is interesting research; however, it is still in the early stages, and further resea...
Source: Arthritis Research UK - February 18, 2016 Category: Rheumatology Source Type: news

Could THIS hot drink help ease the agony of rheumatoid arthritis?
A WONDER compound found in green tea could alleviate the agony of rheumatoid arthritis, a new study suggests. (Source: Daily Express - Health)
Source: Daily Express - Health - February 17, 2016 Category: Consumer Health News Source Type: news

Evidence for Treating Rheumatoid Arthritis to TargetEvidence for Treating Rheumatoid Arthritis to Target
When managing rheumatoid arthritis, does a treat-to-target approach convey better outcomes than routine care? Annals of the Rheumatic Diseases (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 17, 2016 Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

Medical News Today: Green tea compound shows promise for treating rheumatoid arthritis
EGCG - a compound abundant in green tea - was found to reduce ankle swelling in mouse models of rheumatoid arthritis, suggesting it could be a promising treatment for the disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 17, 2016 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

What Really Killed Glenn Frey
When Glenn Frey, a co-founder and driving force behind ’70s supergroup the Eagles, died on January 18, I wasn’t just saddened by the loss. I was deeply concerned about the manner of his death. News reports said Frey died from a combination of “complications” from rheumatoid arthritis (RA), one of the most debilitating chronic diseases. RA is an inflammatory autoimmune condition. It affects the entire body — particularly the joints. The body develops antibodies against its own joint tissues, breaking them down. A modern inflammatory diet, genetic factors and food allergies all play a role in d...
Source: Al Sears, MD Natural Remedies - February 16, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Men's Health arthritis inflammation vitamin D3 Vitamin K2 Source Type: news

Rheumatoid Arthritis Year in Review
(MedPage Today) -- Coverage from the Rheumatology Winter Clinical Symposia (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - February 16, 2016 Category: Geriatrics Source Type: news

Impact of Certolizumab Pegol in Rheumatoid ArthritisImpact of Certolizumab Pegol in Rheumatoid Arthritis
This study takes a look at patient-reported outcomes as well as clinical measures of disease activity. Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 16, 2016 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

The Genetics of Rheumatoid ArthritisThe Genetics of Rheumatoid Arthritis
This review examines the genetic and environmental risk factors that influence the development of rheumatoid arthritis. Rheumatology (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 16, 2016 Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

Cardiac Risks High in Systemic Sclerosis (CME/CE)
(MedPage Today) -- Equivalent to the risks in rheumatoid arthritis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 15, 2016 Category: Cardiology Source Type: news

UK MHRA approves clinical trial of JHL biosimilar to treat RA
The UK's Medicines and Healthcare Products Regulatory Agency (MHRA) has approved a Phase I clinical trial of JHL1101, a potential treatment for rheumatoid arthritis (RA). (Source: Drug Development Technology)
Source: Drug Development Technology - February 15, 2016 Category: Pharmaceuticals Source Type: news

Sandoz buys rights to Pfizer’s infliximab biosimilar in EEA
Novartis' generic pharmaceuticals division Sandoz has acquired rights of Pfizer's PF-06438179, a biosimilar of Merck's Remicade (infliximab), in the European Economic Area (EEA), to treat a range of autoimmune diseases including rheumatoid arthritis … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 15, 2016 Category: Pharmaceuticals Source Type: news

Textile workers at higher risk for rheumatoid arthritis
(Reuters Health) - Breathing textile dust on the job is linked to an almost tripled risk of developing rheumatoid arthritis, an immune system disorder that causes debilitating swelling and pain in the joints, a Malaysian study suggests. (Source: Reuters: Health)
Source: Reuters: Health - February 11, 2016 Category: Consumer Health News Tags: healthNews Source Type: news

Women's Secrets: Clues to a Female Brain?
I was sitting on the train yesterday and couldn't help eavesdropping on the two women sitting in front of me. They looked about 40-something, casually dressed, and from outward appearance rather healthy. Then they started talking about how they're cope with their ailments. One woman has epilepsy and talked about raising a toddler when she worries she may drop her if she seizes, and how she can no longer drive and has to rely on other people to chauffer them around. She also said that because her husband is working crazy hours and she needs a solid night's sleep, they sleep in separate beds during the week. The other woman...
Source: Science - The Huffington Post - February 11, 2016 Category: Science Source Type: news

Anti-TNF therapy linked to ‘modest’ extra SCC risk
A Swedish population-based study shows that treatment with tumour necrosis factor inhibitors significantly increases the risk of developing squamous cell carcinoma, but not basal cell carcinoma, in patients with rheumatoid arthritis. (Source: MedWire News)
Source: MedWire News - February 11, 2016 Category: Consumer Health News Tags: Oncology Source Type: news

Total Cost of Care Will Define Value Propositions
As they move increasingly toward a value-based model, health care systems are also being expected to take on more risk, so every contributor to the total cost of care will increasingly be scrutinized in terms of the value that it brings. Now, life science business leaders have an unrivalled opportunity to learn from senior clinicians and healthcare administrators exactly how these latest trends in the US healthcare landscape are set to impact their commercial organizations. During an extensive live Q&A session on Friday, February 12, three senior healthcare experts will provide privileged insight into “How 2016 H...
Source: EyeForPharma - February 9, 2016 Category: Pharmaceuticals Authors: Nick de Cent Source Type: news

Natural protein points to new inflammation treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 4, 2016 Category: American Health Source Type: news

Baricitinib for the Treatment of Moderate to Severe Rheumatoid Arthritis
Baricitinib is the first once-daily oral selective JAK1 and JAK2 inhibitor for the treatment of moderate to severe active rheumatoid arthritis (RA). (Source: Drug Development Technology)
Source: Drug Development Technology - February 4, 2016 Category: Pharmaceuticals Source Type: news

Dietary Fatty Acids and Fish Oil for the Treatment of OADietary Fatty Acids and Fish Oil for the Treatment of OA
In rheumatoid arthritis, higher doses of fish oil have been associated with pain reduction in the number of tender joints, but what does fish oil do for osteoarthritis patients? Annals of the Rheumatic Diseases (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 3, 2016 Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

Highlights from 2015
Your achievements A massive thank you to everyone who ran, hosted coffee mornings and bake sales, jumped out of planes and trekked across the country and indeed the world to fundraise for us. More than 1,300 of you took on a challenge or donated your time and fundraising skills in 2015. Together, you raised over £780,000! If you’d like to join Team A in 2016 and help raise money for our work, have a look at our events or contact localfundraising@arthritisresearchuk.org Improving care for people with arthritis In 2015 we continued to support healthcare professionals to provide the best care to people with art...
Source: Arthritis Research UK - February 3, 2016 Category: Rheumatology Source Type: news

Strategies to Predict RA Development in At-Risk PopulationsStrategies to Predict RA Development in At-Risk Populations
How can we predict the risk of rheumatoid arthritis in the various preclinical stages? Rheumatology (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 2, 2016 Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

Many Factors Play into Increased Heart Disease Risk for Those with RA
In honor of Rheumatoid Arthritis Awareness Day and National Heart Health Day we are posting a previous Mayo Clinic Q & A article that addresses this issue. DEAR MAYO CLINIC: Is it true that people with rheumatoid arthritis have a higher risk of heart disease? How are the two conditions related? Is there a way to [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 2, 2016 Category: Databases & Libraries Source Type: news

NICE recommends 7 drugs for rheumatoid arthritis
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2016 Category: Drugs & Pharmacology Source Type: news

Encouraging autonomy and self-regulation 'can help rheumatoid arthritis patients stay active'
This study shows that interventions aimed at maintaining motivation can be beneficial to people with this painful and debilitating condition." (Source: Arthritis Research UK)
Source: Arthritis Research UK - February 1, 2016 Category: Rheumatology Source Type: news

RheumNow: Risk of MS With TNF Inhibitor Therapy
(MedPage Today) -- Do standard rheumatoid arthritis drugs promote development of MS? (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 31, 2016 Category: Primary Care Source Type: news

Study shows long-term benefits of golimumab therapy for psoriatic arthritis
New research has demonstrated the potentially significant long-term benefits that golimumab therapy can provide for people with psoriatic arthritis.The international study, led by the University of California, San Diego, aimed to evaluate long-term outcomes in psoriatic arthritis patients who achieved or did not achieve minimal disease activity over five years of golimumab treatment.This placebo-controlled trial lasted 24 weeks and was followed by an open-label extension period of up to five years. Results from the study were published in the medical journal Arthritis Care and Research.It was shown that treatment with goli...
Source: Arthritis Research UK - January 29, 2016 Category: Rheumatology Source Type: news

Antares Pharma Announces CEO Transition
Robert Apple Appointed President and Chief Executive Officer EWING, N.J., Jan. 26, 2016 -- (Healthcare Sales & Marketing Network) -- Antares Pharma, Inc. (ATRS) today announced that its Board of Directors has appointed Robert Apple to the position of Pr... Biopharmaceuticals, PersonnelAntares Pharma, OTREXUP, methotrexate, rheumatoid arthritis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 26, 2016 Category: Pharmaceuticals Source Type: news

NICE issues final guidance for rheumatoid arthritis
NICE recommends that severe rheumatoid arthritis, which has not responded to intensive therapy, is treated with a combination of conventional biological disease modifying drugs Hide related content:  Show related content read more (Source: Nursing in Practice)
Source: Nursing in Practice - January 26, 2016 Category: Nursing Authors: ltrevallion Tags: Women ' s health Care of older people Editor s pick Latest News Source Type: news

RheumNow: 10 Ways RA Could’ve Killed Glenn Frey
(MedPage Today) -- Jack Cush reviews the complications associated with rheumatoid arthritis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 22, 2016 Category: Primary Care Source Type: news

People with inflammatory arthritis let down by health service, new report shows
People with rheumatoid and early inflammatory arthritis are being let down by the health service, a new clinical audit has shown. The audit, led by the British Society of Rheumatology, found that many patients in England and Wales are experiencing long waiting times and delays. A high proportion of services weren't meeting the quality standards set by the National Institute for Health and Care Excellence (NICE), including referral from a GP within 3 days, and assessment in a rheumatology service within 3 weeks of referral. Average wait times According to the audit: only one in six patients were referred by their GP to ...
Source: Arthritis Research UK - January 22, 2016 Category: Rheumatology Source Type: news

Gut bacteria could lead to new treatment for inflammatory arthritis
Studying the trillions of bacteria and other microbes that share our body space could lead to a preventative treatment for immune diseases such as rheumatoid arthritis. It's long been suggested that the bacteria which live in our gut, mouth and elsewhere on our bodies may affect our immune system and lead to the development of certain diseases, including rheumatoid arthritis. But exactly how changes to these bacteria, collectively called the “microbiome”, cause disease remains to be discovered. The research, which we awarded £2 million to, aims to unlock the link between gut bacteria and the development o...
Source: Arthritis Research UK - January 21, 2016 Category: Rheumatology Source Type: news

Motivations for Personalized Genetic Testing Include Explaining -- Not Just Predicting
Last week, I invited the venerable Lee Hood to speak to us at Harvard Medical School, and I was reminded again of his prescience in describing and advocating for "P4 Medicine" -- or predictive, preventive, personalized and participatory medicine -- over 10 years ago, in 2004! And while Lee's vision of P4 Medicine embraces a model of systems biology that is broader than just the genome, the democratization of genetic testing over the past decade falls squarely within the powerful narrative prediction and prevention. Indeed, much of the controversy surrounding direct-to-consumer (DTC) genetic testing when it launch...
Source: Science - The Huffington Post - January 20, 2016 Category: Science Source Type: news