Can an App Reduce the Need for In-Person Visits?
Solomon et al. examined whether a mobile application (app) for patients with rheumatoid arthritis integrated in the electronic health record would be used by patients and rheumatologists. The application collected patient-reported outcomes (PROs) between visits and gave rheumatologists messages regarding clinical status, recommending early or delayed visits based on PROs. In this initial trial, the researchers found high use rates for the app and PRO data, but no association between app use and reduced visit volume. (Source: The Rheumatologist)
Source: The Rheumatologist - April 25, 2024 Category: Rheumatology Authors: Arthritis & Rheumatology Tags: Conditions Rheumatoid Arthritis Arthritis & Rheumatology RA Resource Center Research Rheumatoid Arthritis (RA) Source Type: research
Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint
AbstractThe study of neuroimmune crosstalk and the involvement of neurotransmitters in inflammation and bone health has illustrated their significance in joint-related conditions. One important mode of cell-to-cell communication in the synovial fluid (SF) is through extracellular vesicles (EVs) carrying microRNAs (miRNAs). The role of neurotransmitter receptors in the pathogenesis of inflammatory joint diseases, and whether there are specific miRNAs regulating differentially expressed HTR2A, contributing to the inflammatory processes and bone metabolism is unclear. Expression of neurotransmitter receptors and their corre...
Source: Clinical and Experimental Medicine - April 25, 2024 Category: Research Source Type: research
A novel diagnostic model based on lncRNA PTPRE expression, neutrophil count and red blood cell distribution width for diagnosis of seronegative rheumatoid arthritis
AbstractDiagnosis of seronegative rheumatoid arthritis (SNRA) is difficult due to the lack of diagnostic markers. The study aims to construct a novel diagnostic model based on long noncoding RNAs (lncRNAs) expression and laboratory indicators to provide a new idea for diagnostic methods of SNRA. Differentially expressed lncRNAs in peripheral blood cells of RA patients were screened through eukaryotic long noncoding RNA sequencing and validated by quantitative real-time PCR. Meanwhile, the correlation between lncRNAs expression and laboratory indicators was analyzed. The diagnostic value was evaluated by receiver operating ...
Source: Clinical and Experimental Medicine - April 25, 2024 Category: Research Source Type: research
Identification of potential hub genes and biological mechanism in rheumatoid arthritis and non-small cell lung cancer via integrated bioinformatics analysis
CONCLUSIONS: This study explored the hub genes and related mechanisms of RA and NSCLC, demonstrated the central role of the inflammatory response and the adaptive immune system, and identified PTPRC as an immune-related biomarker and potential therapeutic target for RA and NSCLC patients. In addition, PTPRC can significantly promote the proliferation, migration and invasion of A549 cells, and its mechanism may be to promote the EMT process by regulating the Wnt signaling pathway and promote cell stemness, which in turn has a promoting effect on A549 cells.PMID:38657441 | DOI:10.1016/j.tranon.2024.101964 (Source: Translational Oncology)
Source: Translational Oncology - April 24, 2024 Category: Cancer & Oncology Authors: Junsha An Pingting Chen Xin Li Xiuchuan Li Fu Peng Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
CONCLUSIONS: The HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe.PMID:38656653 | DOI:10.1007/s40121-024-00963-w (Source: Herpes)
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Alen Marijam Nikki Vroom Amit Bhavsar Inga Posiuniene Nicolas Lecrenier Hilde Vroling Source Type: research
Mesenchymal Stem Cells in Autoimmune Disease: A Systematic Review and Meta-Analysis of Pre-Clinical Studies
Biochimie. 2024 Apr 22:S0300-9084(24)00084-1. doi: 10.1016/j.biochi.2024.04.009. Online ahead of print.ABSTRACTMesenchymal Stem Cells (MSCs) are of interest in the clinic because of their immunomodulation capabilities, capacity to act upstream of inflammation, and ability to sense metabolic environments. In standard physiologic conditions, they play a role in maintaining the homeostasis of tissues and organs; however, there is evidence that they can contribute to some autoimmune diseases. Gaining a deeper understanding of the factors that transition MSCs from their physiological function to a pathological role in their nat...
Source: Biochimie - April 24, 2024 Category: Biochemistry Authors: Hailey N Swain Parker D Boyce Bradley A Bromet Kaiden Barozinksy Lacy Hance Dakota Shields Gayla R Olbricht Julie A Semon Source Type: research
Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
AbstractPurpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In this scoping review, we summarize recent evidence detailing the effects of synthetic environmental chemicals on autoimmune diseases and highlight current research gaps and recommendations for future studies.Recent FindingsWe identified 68 recent publications related to environmental chemical exposures and autoimmune diseases. Most studies evaluated exposure to persistent environmental chemicals and autoimmune conditions including rheumatoid arthritis (RA), systemic lu...
Source: Current Environmental Health Reports - April 24, 2024 Category: Environmental Health Source Type: research
Towards better anticoagulation monitoring for extracorporeal membrane oxygenation – Taking C-reactive Protein Out of the Equation?
C-reactive protein (CPR) is an acute phase reactant protein, primarily synthesized in the liver.1 It belongs to the Pentraxin family of the innate immune system, serving as a pattern recognition molecule for phosphorylcholine residues abundant in bacterial cell membranes. It also binds to damaged cells and altered self-antigens, making it a valuable marker for inflammation, particularly in conditions such as rheumatoid arthritis and certain types of vasculitis. CRP exhibits a notable affinity for oxidized phosphatidylcholine (lysophosphatidylcholine) expressed on apoptotic cells and in oxidized low-density lipoproteins (LD...
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 24, 2024 Category: Anesthesiology Authors: Kenichi A. Tanaka, Kenneth E. Steward, Michael A. Mazzeffi Tags: Editorial Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research
Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research
IL-22, a vital cytokine in autoimmune diseases
Clin Exp Immunol. 2024 Apr 23:uxae035. doi: 10.1093/cei/uxae035. Online ahead of print.ABSTRACTInterleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune dis...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Jiajin Li Zhen Wu Yuxin Wu Xin Yu Hu Jun Yang Dacheng Zhu Mingyue Wu Xin Li Lutterodt Bentum-Ennin Wanglai Hu Source Type: research
Association of the multi-biomarker disease activity score with arterial 18-fluorodeoxyglucose uptake in rheumatoid arthritis
CONCLUSIONS: Among treated RA patients, achieved MBDA predicts of changes in arterial inflammation. Achieving low MBDA at 24 weeks was associated with clinically meaningful reductions in arterial inflammation, regardless of treatment.PMID:38652572 | DOI:10.1093/rheumatology/keae242 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Jon T Giles Daniel H Solomon Katherine P Liao Pamela M Rist Zahi A Fayad Ahmed Tawakol Joan M Bathon Source Type: research
Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles
Front Immunol. 2024 Apr 8;15:1383110. doi: 10.3389/fimmu.2024.1383110. eCollection 2024.ABSTRACTExhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we found that the frequency of TIGIT+KLRG1+ TEX is stable within an individual but differs across individuals in both T1D and healthy control (HC) cohorts. This TIGIT+KLRG1+ CD8 TEX population shares an exhaustion-associated EOMES gene signature in HC, T1D, rheumatoid arthritis (RA), and...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Sarah Alice Long Virginia S Muir Britta E Jones Valerie Z Wall Alyssa Ylescupidez Anne M Hocking Stephan Pribitzer Jerill Thorpe Bryce Fuchs Alice E Wiedeman Megan Tatum Katharina Lambert Hannes Uchtenhagen Cate Speake Bernard Ng Alexander T Heubeck Troy Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
