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The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice.
CONCLUSIONS: In this large Australian cohort of unselected community RA patients, the choices of cDMARDs/bDMARDs are aligned with current international guidelines. PMID: 28630629 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 22, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Predictors and social consequences of daily pain expectancy among adults with chronic pain
Abstract: Previous research suggests that for people living with chronic pain, pain expectancy can undermine access to adaptive resources and functioning. We tested and replicated the unique effect of pain expectancy on subsequent pain through 2 daily diary studies. We also extended previous findings by examining cognitive and affective antecedents of pain expectancy and the consequences of pain expectancy for daily social enjoyment and stress. In study 1, 231 individuals with rheumatoid arthritis completed 30 end-of-day diaries. Results of multilevel structural equation model showed that controlling for today's pain, pain...
Source: Pain - June 22, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

One year in review 2017: pathogenesis of rheumatoid arthritis.
Authors: Angelotti F, Parma A, Cafaro G, Capecchi R, Alunno A, Puxeddu I Abstract Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic and environmental factors. It has been postulated that a high-risk genetic background, in combination with epigenetic marks and environmental exposures, leads to a cascade of events inducing synovitis and consequent destructive arthritis. The clinical picture of joint involvement in RA is the result of chronic inflammation of the synovium, characterised by interactions of resident cells such as fibroblast-like synoviocytes (FLS) with cell...
Source: Clinical and Experimental Rheumatology - June 22, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty
This collaboration between the American College of Rheumatology and the American Association of Hip and Knee Surgeons developed an evidence-based guideline for the perioperative management of antirheumatic drug therapy for adults with rheumatoid arthritis (RA), spondyloarthritis (SpA) including ankylosing spondylitis and psoriatic arthritis, juvenile idiopathic arthritis (JIA), or systemic lupus erythematosus (SLE) undergoing elective total hip (THA) or total knee arthroplasty (TKA). (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - June 22, 2017 Category: Orthopaedics Authors: Susan M. Goodman, Bryan Springer, Gordon Guyatt, Matthew P. Abdel, Vinod Dasa, Michael George, Ora Gewurz-Singer, Jon T. Giles, Beverly Johnson, Steve Lee, Lisa A. Mandl, Michael A. Mont, Peter Sculco, Scott Sporer, Louis Stryker, Marat Turgunbaev, Barry Tags: ACR/AAHKS Guidelines for Perioperative Management Source Type: research

Expression of Dicer in rheumatoid arthritis is associated with disease activity and balances the production of TNF ‑α.
Expression of Dicer in rheumatoid arthritis is associated with disease activity and balances the production of TNF‑α. Mol Med Rep. 2017 Jun 09;: Authors: Wang S, Yuan M, Song L, Zhang X, Geng Q, Zhang H, Li X Abstract Gene expression can be altered through RNA interference (RNAi), including microRNA (miRNA) or small interfering RNA. Alterations of miRNAs in rheumatoid arthritis (RA) have been reported, however, the components of the RNAi machinery in RA remain to be fully elucidated. The aim of the present study was to detect the levels of Dicer, Argonaute2 and Drosha, components of the RNAi ma...
Source: Molecular Medicine Reports - June 21, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

IL ‑22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane‑induced arthritis rat model.
In conclusion, Th17 and Th22‑related factor expression varied in different disease progression phases and in different tissues in PIA rats. IL‑22 expression exhibited an increasing trend in the initial phase and the onset phase of arthritis and increased significantly with progression to chronic arthritis in the PIA rat model. It is thought that IL‑22 may serve an important role in the pathological process of PIA, particularly in the chronic fluctuation phase. Therefore, it may be a candidate molecule for the treatment of rheumatoid arthritis. PMID: 28627588 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - June 21, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Six-joint ultrasound in rheumatoid arthritis: a feasible approach for implementing ultrasound in remission.
Authors: Aydin SZ, Gunal EK, Ozata M, Keskin H, Ozturk AB, Emery P, D'Agostino MA Abstract OBJECTIVES: Subclinical disease activity in rheumatoid arthritis (RA) detected by imaging methods is predictive for flares and damage. Lack of time is the major limitation for not screening for subclinical disease in routine practice. We aimed to determine the most feasible protocol to screen patients with no clinical disease activity by ultrasound (US). METHODS: A hundred consecutive RA patients with no clinical activity according to the physician had an US scan for 38 joints. The prevalence of power Doppler (PD) signal ...
Source: Clinical and Experimental Rheumatology - June 21, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pyoderma gangrenosum and underlying diseases in Japanese patients: A regional long ‐term study
In conclusion, ulcerative colitis and hematological disorders were frequently associated with PG while approximately a quarter of the cases were idiopathic. (Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 21, 2017 Category: Dermatology Authors: Sae Inoue, Jun ‐ichi Furuta, Yasuhiro Fujisawa, Saori Onizawa, Shusaku Ito, Masayuki Sakiyama, Keiko Kobayashi, Toshiyuki Kanou, Shigeruko Iijima, Tsunao Ohi, Chimaki Okubo, Yoshihiro Moriyama, Naoko Okiyama, Manabu Fujimoto Tags: Original Article Source Type: research

Berberine ameliorates collagen ‐induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - June 21, 2017 Category: Research Authors: Mengfan Yue, Yufeng Xia, Can Shi, Chunge Guan, Yunfan Li, Rui Liu, Zhifeng Wei, Yue Dai Tags: Original Article Source Type: research

Rheumatoid arthritis is associated with negatively variable impacts on domains of female sexual function: evidence from a systematic review and meta-analysis
. (Source: Psychology, Health and Medicine)
Source: Psychology, Health and Medicine - June 21, 2017 Category: International Medicine & Public Health Authors: Qiuxiang Zhang Congcong Zhou Haoyang Chen Qian Zhao Lin Li Yafei Cui Biyu Shen Source Type: research

Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor
Publication date: August 2017 Source:Journal of Functional Foods, Volume 35 Author(s): Danielle K. Stamer, Saqib A. Nizami, Francis Y. Lee, Do Y. Soung The anti-rheumatic efficacy of grape powder (GP) diet was evaluated in transgenic mice (TG) overexpressing human tumor necrosis factor (TNF), a model for rheumatoid arthritis (RA). After 4-weeks, TG mice fed on 10% of GP showed improvement with epiphyseal bone mass (p=0.07) compared to TG fed on a regular diet. TG mice that received 5 or 10% of GP exhibited a significant (p<0.05) decrease in resorption-associated osteoclasts in paw and knee joints. 10% of GP diet mo...
Source: Journal of Functional Foods - June 21, 2017 Category: Nutrition Source Type: research

Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat
In this study, we investigated whether neuromuscular electrical stimulation (NMES) training protects against skeletal muscle dysfunction in rats with adjuvant-induced arthritis (AIA). AIA was produced by in traarticular injection of complete Freund’s adjuvant into the knees of Wistar rats. For NMES training, dorsiflexor muscles were stimulated via a surface electrode (0.5 ms pulse, 50 Hz, 2 s on/4 s off). NMES training was performed every other day for three weeks and consisted of three sets produced at three min intervals. In each set, the electrical current was set to achieve 60% of the initial maximum isometric to...
Source: PLoS One - June 21, 2017 Category: Biomedical Science Authors: Koichi Himori Source Type: research

In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
CONCLUSION: [(18)F]F-AraG may serve as an imaging biomarker of T-cell activation in inflammatory arthritis. Further development of this technique is warranted and could offer a tool to explore the temporal link between activated T cells and RA as well as to monitor immune-mediated therapies for RA in clinical trials. PMID: 28625080 [PubMed - in process] (Source: Molecular Imaging)
Source: Molecular Imaging - June 20, 2017 Category: Radiology Tags: Mol Imaging Source Type: research

Differential impact of systemic lupus erythematosus and rheumatoid arthritis on health-related quality of life
This study examined and compared health-related quality of life (QoL) in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).MethodsWe included patients from two multicentric cohorts, the Swiss SLE cohort study (SSCS) and the Swiss Clinical Quality Management Program for RA (SCQM-RA). Patients were matched by age, sex and disease duration using the propensity score. Disease activity was assessed by SELENA-SLEDAI in SLE and by DAS-28 in RA. QoL was captured by the short-form 36 (SF-36). The primary outcomes were physical component summary (PCS) and mental component summary (MCS) of the SF-36. Generalized estima...
Source: Quality of Life Research - June 20, 2017 Category: Health Management Source Type: research

Is Aggregatibacter actinomycetemcomitans the missing link between periodontitis and rheumatoid arthritis?
This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Source: Oral Diseases - June 20, 2017 Category: ENT & OMF Authors: David Polak Tags: Invited Commentary Source Type: research

Successful Switch to Golimumab for Eosinophilia and Skin Symptoms Related to Multiple Biologics in a Patient with Rheumatoid Arthritis.
Authors: Azuma N, Matsui K, Hashimoto N, Yoshikawa T, Sano H Abstract Biologics used in the treatment of rheumatoid arthritis (RA) rarely cause eosinophilia. We herein report a patient with RA being treated with infliximab, adalimumab, and tocilizumab who developed eosinophilia with skin symptoms. Interestingly, the marked eosinophilia and skin symptoms did not reappear after the patient's medication was switched to golimumab. In this case, the presence of biologics-specific antibodies suggested that immunogenicity caused the eosinophilia. Therefore, switching to a biologic with a lower immunogenicity was effective...
Source: Internal Medicine - June 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

A 16-year Follow-up Case of Interstitial Pneumonia with Systemic Sclerosis-rheumatoid Arthritis Overlap Syndrome.
Authors: Yamakawa H, Hagiwara E, Yamanaka Y, Ikeda S, Sekine A, Kitamura H, Baba T, Okudela K, Iwasawa T, Takemura T, Ogura T Abstract Interstitial pneumonia is a common and major comorbidity affecting the prognosis of patients with systemic sclerosis (SSc). However, there are few reported cases of SSc-rheumatoid arthritis (RA) overlap-associated interstitial pneumonia. We herein report a case in which the clinical behavior and histopathology of interstitial pneumonia with SSc-RA overlap syndrome was followed over a long clinical course. When clinicians are deciding on the treatment strategy for patients with SSc-R...
Source: Internal Medicine - June 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Identification of the Chemical Constituents in Simiao Wan and Rat Plasma after Oral Administration by GC-MS and LC-MS.
Authors: Fan Y, Li Y, Wu Y, Li L, Wang Y, Li Y Abstract Simiao Wan (SMW), an important multiherbal formula used in traditional Chinese medicine, is extensively used to treat rheumatoid arthritis. However, the knowledge of the bioactive components of SMW remains unclear. Thus, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) were used to analyze the chemical constituents of volatile and nonvolatile extracts of SMW, as well as its absorbed components in rat plasma after oral SMW administration. Identification of several compounds was enabled by comparison of retention t...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

GSE100191 Transcriptional Signature Associated with Early Rheumatoid Arthritis and Healthy Individuals at high risk to develop the disease.
Contributors : N Macias-Segura ; J A Enciso-MorenoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify biomarkers and transcriptomic pathways associated with the development of rheumatoid arhtritis, we performed a transcriptional analysis using a hole genome microarray to demostrate that a specific transcriptional signature is associated with the development of RA, and it exists since the beginning and presence of auto-antibodies against citrulinated proteins. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 20, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Undetectable Mannose Binding Lectin and Corticosteroids Increase Serious Infection Risk in Rheumatoid Arthritis
Conclusions Undetectable MBL and prednisolone confer a high risk for an SI. The use of biologic DMARDs did not confer substantial SI risk in this observational study. MBL deficiency is hitherto an unrecognized risk factor for an SI in RA. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 20, 2017 Category: Allergy & Immunology Source Type: research

High-Frame-Rate Power Doppler Ultrasound Is More Sensitive than Conventional Power Doppler in Detecting Rheumatic Vascularisation
Early recognition of joint inflammation will increase treatment efficacy in rheumatoid arthritis (RA). Yet, conventional power Doppler (PD) ultrasound might not be sufficiently sensitive to detect minor inflammation. We investigated the sensitivity of high-frame rate Doppler, combined with singular value decomposition technique, to suppress tissue signals, for microvascular flow in a flow phantom setup and in a proof-of-principle study in healthy controls and in RA patients with different disease activities. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 20, 2017 Category: Radiology Authors: Myrthe van der Ven, Jolanda J. Luime, Levinia L. van der Velden, Johan G. Bosch, Johanna M.W. Hazes, Hendrik J. Vos Tags: Original Contribution Source Type: research

Dynamic In Vivo 3D Atlantoaxial Spine Kinematics During Upright Rotation
Diagnosing dysfunctional atlantoaxial motion is challenging given limitations of current diagnostic imaging techniques. Three-dimensional imaging during upright functional motion may be useful in identifying dynamic instability not apparent on static imaging. Abnormal atlantoaxial motion has been linked to numerous pathologies including whiplash, cervicogenic headaches, C2 fractures, and rheumatoid arthritis. However, normal C1/C2 rotational kinematics under dynamic physiologic loading have not been previously reported owing to imaging difficulties. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - June 20, 2017 Category: Biomedical Science Authors: William Anderst, Bryan Rynearson, Tyler West, William Donaldson, Joon Lee Source Type: research

High titer of anti ‐citrullinated peptide antibody is a risk factor for severe carotid atherosclerotic plaque in patients with rheumatoid arthritis: the TOMORROW study
ConclusionHigh prevalence of any carotid plaques and severe carotid plaques were more frequent in patients with RA. High titer of anti‐CCP antibodies represented a risk factor for severe carotid atherosclerotic plaque in patients with RA. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - June 19, 2017 Category: Rheumatology Authors: Tadashi Okano, Kentaro Inui, Yuko Sugioka, Kenichi Sugioka, Yoshiki Matsumura, Shinji Takahashi, Masahiro Tada, Kenji Mamoto, Shigeyuki Wakitani, Tatsuya Koike, Hiroaki Nakamura Tags: Original Article Source Type: research

Adherence of rheumatoid arthritis patients to biologic disease-modifying antirheumatic drugs: a cross-sectional study
AbstractThe aims of this study were to evaluate adherence of rheumatoid arthritis (RA) patients to biological disease-modifying antirheumatic drugs (bDMARDs), identify potential risk factors, and analyze the discriminative ability of the Morisky –Green test (MGT) to detect bDMARD nonadherence. One hundred and seventy-eight adult RA patients treated with bDMARDs were included. Adherence was measured using the medication possession ratio (MPR) of the previous 6 months. An MPR >80% was considered good adherence. Patient demographics, clinical characteristics, and MGT scores were assessed through a standardi...
Source: Rheumatology International - June 19, 2017 Category: Rheumatology Source Type: research

Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace
AbstractPurpose of ReviewRheumatoid vasculitis (RV) is an unusual complication of long-standing rheumatoid arthritis, which is characterized by the development of necrotizing or leukocytoclastic vasculitis involving small or medium-sized vessels. In this review, we aim to provide an update on the epidemiology, pathogenesis, clinical presentation, and management of this challenging extra-articular manifestation.Recent FindingsRV is heterogenous in its clinical presentation depending on the organ and size of blood vessels involved. The most common organs involved are the skin and peripheral nerve. Based on recent population ...
Source: Current Rheumatology Reports - June 19, 2017 Category: Rheumatology Source Type: research

Framework for Advancing the Reporting of Patient Engagement in Rheumatology Research Projects
AbstractPurpose of ReviewThe term “patient engagement in research” refers to patients and their surrogates undertaking roles in the research process beyond those of study participants. This paper proposes a new framework for describing patient engagement in research, based on analysis of 30 publications related to patient engage ment.Recent FindingsOver the past 15  years, patients’ perspectives have been instrumental in broadening the scope of rheumatology research and outcome measurement, such as evaluating fatigue in rheumatoid arthritis. Recent reviews, however, highlight low-quality reporting of...
Source: Current Rheumatology Reports - June 19, 2017 Category: Rheumatology Source Type: research

Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis
AbstractBackgroundInflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive pain crises (VOC) in SCD patients.MethodsFourteen adults on hydroxyurea with severe and refractory VOC received one intramuscular injection of 10  mg of MTX per week for 12 weeks. A single weekly dose of 5 mg of leucovorin was administered orally 48 h after each MTX injection. The primary outcome was reduction in number/intensity of acute pain episodes. The secondary outcomes were ...
Source: Experimental Hematology and Oncology - June 19, 2017 Category: Cancer & Oncology Source Type: research

UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice
Publication date: June 2017 Source:Chinese Journal of Natural Medicines, Volume 15, Issue 6 Author(s): Zhuo WANG, Jian-Qun LIU, Jin-Di XU, He ZHU, Ming KONG, Guo-Hua ZHANG, Su-Min DUAN, Xiu-Yang LI, Guang-Fu LI, Li-Fang LIU, Song-Lin LI Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have ...
Source: Chinese Journal of Natural Medicines - June 19, 2017 Category: Complementary Medicine Source Type: research

Can rheumatoid arthritis affect sleep in Egyptian patients?
Conclusion A high frequency of sleep disturbances in RA patients was observed. Interplay of pain, fatigue, activity and disability may lead to poor sleep quality. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - June 19, 2017 Category: Rheumatology Source Type: research

Conventional Radiology in Rheumatoid Arthritis
In clinical practice, conventional radiograph is still the radiologic method for the diagnosis of rheumatoid arthritis (RA). Moreover, it provides a quick overview of the symptomatic joints, to narrow the differential diagnosis, and to evaluate progression. RA is a polyarticular disease with bilateral and symmetric involvement of the peripheral joints, especially small joints, and less frequently, the cervical spine. The radiologic features are soft tissue swelling, periarticular osteoporosis, erosions, loss of joint space, and in advanced disease, osteolysis and typical subluxations or deformities, such as ulnar deviation...
Source: Radiologic Clinics of North America - June 19, 2017 Category: Radiology Authors: Eva Llopis, Herman M. Kroon, Jose Acosta, Johan L. Bloem Source Type: research

Antiinflammatory and antioxidant effects of gemcitabine in collagen-induced arthritis model.
CONCLUSION: GEM suppresses cytokine levels and enhances antioxidant activity. It also prevents cartilage/bone destruction in the CIA model. GEM may be a viable candidate for research into the treatment of RA. PMID: 28618762 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - June 18, 2017 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Pain, depression levels, fatigue, sleep quality, and quality of life in elderly patients with rheumatoid arthritis.
CONCLUSION: This study evaluated the situation in elderly patients with RA and showed that pain, depression level, fatigue, and sleep quality worsen with age. PMID: 28618733 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - June 18, 2017 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Differential changes in the pharmacokinetics of statins in collagen-induced arthritis rats.
Abstract The elevated systemic levels of cytokines in rheumatoid arthritis (RA) can change the expression of metabolic enzymes and transporters. Given that statins are lipid-lowering agents frequently used in RA patients with concurrent cardiovascular diseases, the objective of the present study was to investigate the impacts of RA on the pharmacokinetics of statins of different disposition properties in rats with collagen-induced arthritis (CIA). The expression of metabolic enzymes and transporters in tissues of CIA rats were analyzed by RT-qPCR. Statins were given to CIA rats and controls through different route...
Source: Biochemical Pharmacology - June 18, 2017 Category: Drugs & Pharmacology Authors: Lin CH, Hsu KW, Chen CH, Uang YS, Lin CJ Tags: Biochem Pharmacol Source Type: research

Blockade of IL-17 alleviated inflammation in rat arthritis and MMP-13 expression.
CONCLUSIONS: IL-17A inhibits COL2A1 mRNA and protein expression of chondrocyte in the co-culture system via inducing MMP-13 expression in FLS, thus enhancing collagen degradation and playing a role in RA-related cartilage injury. PMID: 28617559 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Treating active rheumatoid arthritis with Janus kinase inhibitors
Publication date: Available online 16 June 2017 Source:The Lancet Author(s): David L Scott, Matt D Stevenson (Source: The Lancet)
Source: The Lancet - June 17, 2017 Category: General Medicine Source Type: research

Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial
Publication date: Available online 16 June 2017 Source:The Lancet Author(s): Roy Fleischmann, Eduardo Mysler, Stephen Hall, Alan J Kivitz, Robert J Moots, Zhen Luo, Ryan DeMasi, Koshika Soma, Richard Zhang, Liza Takiya, Svitlana Tatulych, Christopher Mojcik, Sriram Krishnaswami, Sujatha Menon, Josef S Smolen Background Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy aimed to assess the comparative efficacy of tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate for the treatment of rheumatoid ar...
Source: The Lancet - June 17, 2017 Category: General Medicine Source Type: research

A time-adjustable pulsatile release system for ketoprofen: in vitro and in vivo investigation in a pharmacokinetic study and an IVIVC evaluation.
Abstract A time-adjustable pulsatile release system (TAPS) containing ketoprofen (KF) as an active pharmaceutical agent was developed having been designed for bedtime dosing and releasing drug in the early morning to control the symptoms of rheumatoid arthritis (RA). The formulation involved a tablet core (KF) and a control-release layer, and the coating membrane was composed of EC and Eudragit L100. A single-factor study, a central composite design and a response surface method were selected to optimize the formula and the optimum prescription was as follows: tablet core (KF 50mg, MCC 70mg, lactose 40mg, L-HPC 38...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 17, 2017 Category: Drugs & Pharmacology Authors: Wang H, Cheng L, Wen H, Li C, Li Y, Zhang X, Wang Y, Wang Y, Wang T, Pan W, Yang X Tags: Eur J Pharm Biopharm Source Type: research

The Diagnosis and Treatment of Sj ögren's Syndrome.
CONCLUSION: The main considerations in the interdisciplinary care of patients with Sjögren's disease are measures to improve quality of life, pharmacological and non-pharmacological treatments to keep disease activity in check, and management of the risk of lymphoma. Future therapeutic approaches must take the heterogeneity of the disease into account. PMID: 28610655 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - June 16, 2017 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty
ConclusionThis guideline should help decision‐making by clinicians and patients regarding perioperative antirheumatic medication management at the time of elective THA or TKA. These conditional recommendations reflect the paucity of high‐quality direct randomized controlled trial data. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 16, 2017 Category: Rheumatology Authors: Susan M. Goodman, Bryan Springer, Gordon Guyatt, Matthew P. Abdel, Vinod Dasa, Michael George, Ora Gewurz ‐Singer, Jon T. Giles, Beverly Johnson, Steve Lee, Lisa A. Mandl, Michael A. Mont, Peter Sculco, Scott Sporer, Louis Stryker, Marat Turgunbaev, Bar Tags: Special Article Source Type: research

Clinical Practice Guidelines: Incorporating Input From a Patient Panel
ConclusionThe Voting Panel considered the importance that the patients placed on risk of infection. The Patient Panel's values informed the direction and strength of the recommendations in the final 2017 ACR/AAHKS guideline. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - June 16, 2017 Category: Rheumatology Authors: Susan M. Goodman, Amy S. Miller, Marat Turgunbaev, Gordon Guyatt, Adolph Yates, Bryan Springer, Jasvinder A. Singh Tags: Special Article Source Type: research

2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty
ConclusionThis guideline should help decision‐making by clinicians and patients regarding perioperative antirheumatic medication management at the time of elective THA or TKA. These conditional recommendations reflect the paucity of high‐quality direct randomized controlled trial data. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - June 16, 2017 Category: Rheumatology Authors: Susan M. Goodman, Bryan Springer, Gordon Guyatt, Matthew P. Abdel, Vinod Dasa, Michael George, Ora Gewurz ‐Singer, Jon T. Giles, Beverly Johnson, Steve Lee, Lisa A. Mandl, Michael A. Mont, Peter Sculco, Scott Sporer, Louis Stryker, Marat Turgunbaev, Bar Tags: Special Article Source Type: research

Effects of co-treatment with pioglitazone and methotrexate on experimentally induced rheumatoid arthritis in Wistar albino rats
CONCLUSION: The present study demonstrates that the combination therapy of MTX with pioglitazone offers better control of disease activities in RA as compared to MTX or pioglitazone monotherapy. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 16, 2017 Category: Drugs & Pharmacology Authors: Tanushree Roy Indranil Banerjee Saikat Ghosh Ranjita Santra Dhali Anuradha De Pati Santanu Kumar Tripathi Source Type: research

Palmoplantar exfoliation due to chloroquine
Pragya Ashok Nair, Trusha PatelIndian Journal of Pharmacology 2017 49(2):205-207Chloroquine is the drug very frequently used for the treatment of malaria. It is also used in amebiasis, rheumatoid arthritis, and various dermatological conditions. Chloroquine can cause muscle problems, loss of appetite, and diarrhea as a side effect. Cutaneous toxicity includes pruritus, hair loss, photosensitivity, and color changes. Exfoliation of skin over palms and soles is caused by chemotherapeutic drugs such as axitinib, fluorouracil, idarubicin, doxorubicin, sunitinib, sorafenib, and paclitaxel. Here, a case of a 40-year-old female i...
Source: Indian Journal of Pharmacology - June 16, 2017 Category: Drugs & Pharmacology Authors: Pragya Ashok Nair Trusha Patel Source Type: research

Benefit-risk trade-offs for treatment decisions in moderate-to-severe rheumatoid arthritis: focus on the patient perspective
AbstractGiven the increasing number of available treatments for rheumatoid arthritis (RA) with varying efficacy and safety profiles, it is critical to understand the level of trade-offs that patients are willing to make between benefits and risks. Adult patients with moderate to severe RA were invited to participate in a discrete choice experiment that solicited their preferences for hypothetical RA treatments. Each participant was presented with 14 choice cards asking about their preference between two hypothetical RA treatments with varying levels of efficacy, adverse events, and process-related attributes. A multivariab...
Source: Rheumatology International - June 16, 2017 Category: Rheumatology Source Type: research

Erratum to: Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients
(Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - June 16, 2017 Category: Orthopaedics Authors: Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri Source Type: research

Advanced Power Doppler Technique Increases Synovial Vascularity Detection in Patients with Rheumatoid Arthritis
We compared the diagnostic performance of an advanced power Doppler technique (superb microvascular imaging [SMI]) with that of power Doppler Imaging (PDI) and B-mode ultrasound (US) in patients with early rheumatoid arthritis (RA) and RA under treatment with rituximab. Thirty patients (21 women aged 45  ± 11 y) affected by RA with remission to moderate disease activity were examined. Both hand joints were evaluated using US, PDI and SMI. Two radiologists reviewed all video clips and evaluated synovial vascularity intensity using a semi-quantitative scoring system. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 16, 2017 Category: Radiology Authors: Davide Orlandi, Salvatore Gitto, Silvia Perugin Bernardi, Angelo Corazza, Luca De Flaviis, Enzo Silvestri, Marco Amedeo Cimmino, Luca Maria Sconfienza Tags: Original Contribution Source Type: research

Efficacy, safety, pharmacokinetics, and pharmacodynamics of filgotinib, a selective Janus kinase 1 inhibitor, after short ‐term treatment of rheumatoid arthritis: Results of two randomized Phase IIA trials
Conclusion. Selective inhibition of JAK1 by filgotinib shows initial efficacy in RA with an encouraging safety profile in these exploratory studies. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 16, 2017 Category: Rheumatology Authors: Fr édéric Vanhoutte, Minodora Mazur, Oleksandr Voloshyn, Mykola Stanislavchuk, Annegret Van der Aa, Florence Namour, René Galien, Luc Meuleners, Gerben van ‘t Klooster Tags: Full Length Source Type: research

“Determinants of perceived health non‐improvement in early rheumatoid arthritis patients with favorable treatment outcomes”
Abstract OBJECTIVE: The aim of this study was to explore the association between achieving favorable clinical outcomes and patients' perceived change in overall health status after 12 months of treat to target (T2T) in patients with early rheumatoid arthritis and to identify determinants of subjective non‐improvement. METHODS: Baseline and 12 month data of patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study with at least a moderate EULAR response after 1 year were selected for analysis. Logistic regression analysis was used to identify factors associated with non‐improved per...
Source: Arthritis Care and Research - June 16, 2017 Category: Rheumatology Authors: M.A.H. Oude Voshaar, L.M.M. Steunebrink, E. Taal, H.E. Vonkeman, T.R. Zijlstra, M.A.F.J. van de Laar Tags: Original Article Source Type: research

Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse.
Köhl J Abstract C3a exerts multiple biologic functions through activation of its cognate C3a receptor. C3(-/-) and C3aR(-/-) mice have been instrumental in defining important roles of the C3a/C3aR axis in the regulation of acute and chronic inflammatory diseases, including ischemia/reperfusion injury, allergic asthma, autoimmune nephritis, and rheumatoid arthritis. Surprisingly little is known about C3aR expression and function in immune and stromal cells. To close this gap, we generated a floxed tandem-dye Tomato (tdTomato)-C3aR reporter knock-in mouse, which we used to monitor C3aR expression in cells resid...
Source: Journal of Immunology - June 16, 2017 Category: Allergy & Immunology Authors: Quell KM, Karsten CM, Kordowski A, Almeida LN, Briukhovetska D, Wiese AV, Sun J, Ender F, Antoniou K, Schröder T, Schmudde I, Berger JL, König P, Vollbrandt T, Laumonnier Y, Köhl J Tags: J Immunol Source Type: research

Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients
Conclusions: This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.Cell Physiol Biochem 2017;42:651 –659 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - June 15, 2017 Category: Cytology Source Type: research