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The Role of Innate lymphoid cells in health and disease
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - October 23, 2017 Category: Cytology Authors: Hamed Mohammadi, Nadia Sharafkandi, Maryam Hemmatzadeh, Gholamreza Azizi, Mohammad Karimi, Farhad Jadidi ‐Niaragh, Behzad Baradaran, Zohreh Babaloo Tags: REVIEW ARTICLE Source Type: research

Uncaria tomentosa.
Authors: Della Valle V Abstract Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) and it may also have potential as an immunomodulating adaptogen in cellular aging. The understanding of some specific mechanisms of molecular action leads to the de...
Source: Giornale Italiano di Dermatologia e Venereologia - October 22, 2017 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Effectiveness of an overall progressive resistance strength program for improving the functional capacity of patients with rheumatoid arthritis: a randomized controlled trial.
CONCLUSIONS: This progressive resistance strength training improves physical function as well as grip and muscular strength of knee flexors, shoulder abductors and wrist extensors in patients with RA, without adverse effects. PMID: 29050507 [PubMed - in process] (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - October 22, 2017 Category: Rehabilitation Authors: Lourenzi FM, Jones A, Pereira DF, Santos JHCAD, Furtado RNV, Natour J Tags: Clin Rehabil Source Type: research

Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD.
Authors: Kovacs L, Su Y Abstract The calcium-dependent cytosolic, neutral, thiol endopeptidases, calpains, perform limited cleavage of their substrates thereby irreversibly changing their functions. Calpains have been shown to be involved in several physiological processes such as cell motility, proliferation, cell cycle, signal transduction, and apoptosis. Overactivation of calpain or mutations in the calpain genes contribute to a number of pathological conditions including neurodegenerative disorders, rheumatoid arthritis, cancer, and lung diseases. High concentrations of reactive oxygen and nitrogen species (RON...
Source: Advances in Experimental Medicine and Biology - October 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Neurologic Manifestations of Rheumatic Diseases
As Sarah Goglin and John Imboden point out, neurologic manifestations of rheumatic diseases often represent sources of confusion and quandary resulting in delay of diagnosis and institution of management. The purpose of this issue is to clarify as much as possible the latest advances in our understanding of these challenges and to place them in a format that is user-friendly for the rheumatologist. Sarah and John have done a truly remarkable job here. All our inflammatory rheumatic diseases have neurologic manifestations, and from a historical perspective, these manifestations may have dominated the clinical picture in yea...
Source: Rheumatic Disease Clinics of North America - October 21, 2017 Category: Rheumatology Authors: Michael H. Weisman Tags: Foreword Source Type: research

Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma.
Authors: Ren A, Fu G, Qiu Y, Cui H Abstract Oral squamous cell carcinoma (OSCC) is the most prevalent pathological cancer occurring in the head and neck area. Progress has previously been made regarding treatment strategies of OSCC, however the 5‑year survival rate of these patients is only 50%. The present study examined if leflunomide (LEF), a drug primarily used for the treatment of rheumatoid arthritis, exhibited antitumor effects in OSCC. The results demonstrated that LEF inhibited cell proliferation and blocked the cell cycle at the S phase in OSCC cells, with upregulation of cyclin A protein expression. LE...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibitory effects of ubiquitination of synoviolin by PADI4.
Authors: Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T Abstract Rheumatoid arthritis (RA) is a chronic inflammatory articular disease that is characterized by synovial hyperplasia. A number of signaling pathways are associated with the development and induced symptoms of RA. Notably, patients with RA have increased protein citrullination and generation of auto‑antibodies against citrullinated proteins. Genome wide association studies have revealed that peptidyl‑arginine deiminase 4 (PADI4) is an enzyme implicated in citrullination in the RA synovium. Autoantibodies targeting citrul...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pharmaceutical Pricing in Japan: Market Evidence for Rheumatoid Arthritis treatment.
CONCLUSION: Although the existing pricing rules in Japan are very comprehensive they do not necessarily capture differences in product characteristics. The findings here support the notion that competitive forces are weak in highly regulated markets such as Japan. PMID: 29039214 [PubMed - as supplied by publisher] (Source: Expert Review of Pharmacoeconomics and Outcomes Research)
Source: Expert Review of Pharmacoeconomics and Outcomes Research - October 20, 2017 Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research

Automatic Quantification of Radiographic Wrist Joint Space Width of Patients With Rheumatoid Arthritis
Conclusion: The proposed method is able to automatically quantify the JSW of radiographic wrist joints reliably. Significance: The proposed method may aid clinical researchers to study the progression of wrist joint damage in RA studies. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 20, 2017 Category: Biomedical Engineering Source Type: research

Switching Between Biological Treatments in Psoriatic Arthritis: A Review of the Evidence
AbstractPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy. Therapy with anti-tumor necrosis factor (TNF)- α agents represents the first therapeutic choice for moderate and severe forms; however, PsA patients can experience anti-TNFα failure, lack of efficacy, or adverse events. Several evidences exist on the effectiveness of switching among different TNFα inhibitors, and we reviewed the published dat a on the effectiveness of anti-TNFα first-, second- and third-line. Most of the studies report that the main reason for switching to a second anti-TNFα agent is represented by lack o...
Source: Drugs in R&D - October 20, 2017 Category: Drugs & Pharmacology Source Type: research

Supramolecular nano-engineered lipidic carriers based on diflunisal-phospholipid complex for transdermal delivery: QbD based optimization, characterization and preclinical investigations for management of rheumatoid arthritis
Publication date: 25 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 1 Author(s): Amanpreet Kaur, Bhupinder Singh Bhoop, Sanjay Chhibber, Gajanand Sharma, Vijay Singh Gondil, Om Prakash Katare Diflunisal (DIF) is used for treatment of rheumatoid arthritis, osteoarthritis etc. DIF-phospholipid complex (DIF-PL complex) was prepared by solvent-evaporation method and characterized by molecular docking studies, SEM, FTIR, DSC, PXRD studies. Further, the DIF-PL complex was incorporated into supramolecular nano-engineered lipidic carriers (SNLCs) for transdermal delivery. The optimization exercise ...
Source: International Journal of Pharmaceutics - October 20, 2017 Category: Drugs & Pharmacology Source Type: research

Smoking habits and anti-CCP antibodies in patients with Rheumatoid Arthritis Gabriela Chirea
Background (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - October 20, 2017 Category: General Medicine Source Type: research

Circulating levels of proinflammatory mediators as potential biomarkers of post-traumatic knee osteoarthritis development
ConclusionsCirculating NOx level and a combination of IL-6 and leptin permitted the strongest discrimination of patients with PTOA from controls. PTOA severity was correlated with leptin levels in plasma and SF and with the synovial IL-18 level. Early PTOA was associated with the circulating level of IL-1 β.Level of evidenceIII (case –control study). (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - October 20, 2017 Category: Orthopaedics Source Type: research

Expression of CCR3, SOX5 and LC3 in patients with elderly onset rheumatoid arthritis and the clinical significance.
This study investigated the expression of C-C chemokine receptor type 3 (CCR3), transcription factor SOX5 (SOX5) and microtubule-associated protein 1 light chain 3 (LC3) in patients with elderly onset rheumatoid arthritis (EORA) and the clinical significance. Ninety patients with elderly onset rheumatoid arthritis were selected in our hospital from January to December in 2016 to serve as patient group. At the same time, 50 healthy people were selected as control group. Levels of CCR3, SOX5 and LC3 in serum of two groups were detected by enzyme-linked immunosorbent assay (ELISA). Expression levels of CCR3, SOX5 and LC3 mRNA...
Source: Experimental and Therapeutic Medicine - October 19, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

The Use of Mapping to Estimate Health State Utility Values
This article provides an overview of the latest recommendations including pre-mapping considerations, the mapping process including data requirements for undertaking the estimation of mapping functions, regression models for estimating mapping functions, assessing performance and reporting standards for mapping studies. Examples in rheumatoid arthritis are used for illustration. When reporting the results of mapping standards the following should be reported: a description of the dataset used (including distributions of variables used) and any analysis used to inform the selection of the model type and model specification....
Source: PharmacoEconomics - October 19, 2017 Category: Health Management Source Type: research

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies
Abstract The advances achieved by cell‐based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents which, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom‐made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory and anti‐inflammatory properties. This has directed ...
Source: Journal of Tissue Engineering and Regenerative Medicine - October 19, 2017 Category: Biotechnology Authors: Daniel B. Rodrigues, Joaquim M. Oliveira, T írcia C. Santos, Rui L. Reis Tags: REVIEW Source Type: research

The effects of interleukin-6 neutralizing antibodies on symptoms of depressed mood and anhedonia in patients with rheumatoid arthritis and multicentric Castleman ’s disease
Publication date: November 2017 Source:Brain, Behavior, and Immunity, Volume 66 Author(s): Yu Sun, Dai Wang, Giacomo Salvadore, Benjamin Hsu, Mark Curran, Corey Casper, Jessica Vermeulen, Justine M. Kent, Jaskaran Singh, Wayne C. Drevets, Gayle M. Wittenberg, Guang Chen Cytokines, including interleukin-6 (IL-6), modulate neuronal plasticity and stress coping. Depressive symptoms and major depressive disorder (MDD) have been associated with changes in cytokines and their signaling. The current study examined the effect of IL-6 monoclonal antibody administration on depressive symptoms in patients with rheumatoid arthritis (...
Source: Brain, Behavior, and Immunity - October 19, 2017 Category: Neurology Source Type: research

RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts
Solomon A. Agere, Nahid Akhtar, Jeffery M. Watson, Salahuddin Ahmed (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 18, 2017 Category: Allergy & Immunology Source Type: research

[Pyopneumothorax in rheumatoid arthritis].
CONCLUSIONS: We describe a case of RA complicated by a pyopneumothorax after treatment with LEF. The risk of this complication could be reduced by regular chest imaging. PMID: 29033202 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 18, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Recipients ’ and providers’ perspectives of obesity and potential barriers to weight management programmes in patients with Rheumatoid Arthritis (RA): a qualitative study
ConclusionPerceptions of obesity and weight gain and associated barriers to participating in weight management programmes, differ significantly between patients and providers. Patients, require a holistic approach to weight management by clinicians and the acknowledgement of the significant psychosocial impact of a dual diagnosis of RA and being overweight or obese. In contrast, providers seem reluctant to address weight increase with patients and require education and support at an individual and institutional level to integrate weight management into routine care. (Source: BMC Obesity)
Source: BMC Obesity - October 18, 2017 Category: Eating Disorders & Weight Management Source Type: research

Factors Associated with Use of Disease Modifying Agents for Rheumatoid Arthritis in the National Hospital and Ambulatory Medical Care Survey
We examined the treatment patterns among adults with rheumatoid arthritis (RA) and identified factors influencing access to traditional and biological disease modifying antirheumatic drugs (DMARDs). (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - October 18, 2017 Category: Rheumatology Authors: Priyanka Gaitonde, Laura M. Bozzi, Fadia T. Shaya Source Type: research

A review of sarilumab for the treatment of rheumatoid arthritis
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - October 18, 2017 Category: Allergy & Immunology Authors: Eun Bong Lee Source Type: research

Tofacitinib in the treatment of active rheumatoid arthritis in adults
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - October 18, 2017 Category: Allergy & Immunology Authors: Roy Fleischmann Source Type: research

Pelvic fractures after definitive and postoperative radiotherapy for cervical cancer: A retrospective analysis of risk factors.
CONCLUSIONS: The incidence rate of PIF among patients who received RT for locally advanced cervical cancer was 15.8%. The principal predisposing factors for post-radiation PIF were postmenopausal state, rheumatoid arthritis, and HDR-ICBT use. Active interventions, including bone density screening followed by medication, should be considered during the early stage of RT for women with high-risk factors of PIF. PMID: 29055558 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 18, 2017 Category: Cancer & Oncology Authors: Yamamoto K, Nagao S, Suzuki K, Kogiku A, Senda T, Yano H, Kitai M, Shiozaki T, Matsuoka K, Yamaguchi S Tags: Gynecol Oncol Source Type: research

Down-titration of biologics for the treatment of rheumatoid arthritis: a systematic literature review
AbstractBiologic therapies have improved the management of rheumatoid arthritis (RA) and the treat-to-target approach has resulted in many patients achieving remission. In the current treatment landscape, clinicians have begun considering dose reduction/tapering for their patients. Rheumatology guidelines in Asia, Europe, and the United States include down-titration of biologics but admit that the level of evidence is moderate. We conducted a systematic literature review to assess the published studies that evaluate down-titration of biologics in RA. The published literature was searched for studies that down-titrated the ...
Source: Rheumatology International - October 17, 2017 Category: Rheumatology Source Type: research

Rates of Joint Replacement Surgery in New Zealand, 1999-2015: A Comparison of Rheumatoid Arthritis and Osteoarthritis.
CONCLUSION: There has been a substantial increase in joint replacement for OA in New Zealand. For RA, where access to biologics has been limited to those with erosions, joint replacement rates have not declined, with the exception of elbow replacements. PMID: 29032353 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Use of Primary Prevention Statin Therapy in Those Predisposed to Atherosclerosis
AbstractPurpose of ReviewMany guidelines exist for the use of statins in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Few have focused on disease specific states that predispose to ASCVD. This review is intended to focus on the recommendations and evidence in inflammatory diseases that predispose to an increased risk of ASCVD beyond what conventional cardiac risk scores would predict.Recent FindingsCertain autoimmune inflammatory diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), and psoriasis/psoriatic arthritis have all been shown to increase the risk of ASCVD. Oth...
Source: Current Atherosclerosis Reports - October 17, 2017 Category: Cardiology Source Type: research

Gingival tissue, an extrasynovial source of malondialdehyde ‐acetaldehyde adducts, citrullinated and carbamylated proteins
ConclusionThis study provides evidence for the presence of citrullinated, carbamylated and MAA adduct modified proteins in inflamed periodontal tissues. The potential for these proteins to play a role in autoimmunity in a multi‐system inflammatory syndromic disease model now needs to be determined. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - October 17, 2017 Category: Dentistry Authors: R. Bright, G. M. Thiele, J. Manavis, T. R. Mikuls, J. B. Payne, P. M. Bartold Tags: SHORT COMMUNICATION Source Type: research

HAQ score is an independent predictor of sustained remission in patients with rheumatoid arthritis: methodological issues
(Source: Rheumatology International)
Source: Rheumatology International - October 17, 2017 Category: Rheumatology Source Type: research

Dose/Exposure ‐Response Modeling to Support Dosing Recommendation for Phase III Development of Baricitinib in Patients with Rheumatoid Arthritis
Baricitinib is an oral inhibitor of Janus kinases (JAKs), selective for JAK1 and 2. It demonstrated dose‐dependent efficacy in patients with moderate‐to‐severe rheumatoid arthritis (RA) in a phase IIb study up to 24 weeks. Population pharmacokinetic/pharmacodynamic (PopPK/PD) models were developed to characterize concentration‐time profiles and dose/exposure‐response (D/E‐R) relationships for the key efficacy (proportion of patients achieving American College of Rheumatology 20%, 50%, or 70% response rate) and safety endpoints (incidence of anemia) for the phase IIb study. The modeling suggested that 4 mg q.d. ...
Source: CPT: Pharmacometrics and Systems Pharmacology - October 17, 2017 Category: Drugs & Pharmacology Authors: Xin Zhang, Laiyi Chua, Charles Ernest, William Macias, Terence Rooney, Lai San Tham Tags: Article Source Type: research

Comparison of the clinical effectiveness of US grading scoring system vs MRI in the diagnosis of early rheumatoid arthritis (RA)
As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and respon... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - October 17, 2017 Category: Orthopaedics Authors: Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang and Pan Mao Tags: Research article Source Type: research

Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis
Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence probably due to atherosclerosis... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 17, 2017 Category: Rheumatology Authors: Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Smastuen, Stefan Agewall, Torstein Lyberg, Nicoletta Ronda, Knut Mikkelsen, Gunnbjorg Hjeltnes and Ivana Hollan Tags: Research article Source Type: research

Incretins in patients with rheumatoid arthritis
The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 17, 2017 Category: Rheumatology Authors: Beatriz Tejera-Segura, Raquel L ópez-Mejías, María Jesús Domínguez-Luis, Antonia M. de Vera-González, Alejandra González-Delgado, Begoña Ubilla, José M. Olmos, José L. Hernández, Miguel A. González-Gay and Iván Ferraz-Amaro Tags: Research article Source Type: research

A new bioassay for measuring the strength of IL-6/STAT3 signal inhibition by tocilizumab in patients with rheumatoid arthritis
Interleukin-6 (IL-6) transduces signals via phosphorylation of STAT3 (pSTAT3). Tocilizumab (TCZ) is an IL-6 receptor blocker, which, when administered intravenously every 4 weeks, efficiently ameliorates rheum... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 17, 2017 Category: Rheumatology Authors: Shuntaro Saito, Katsuya Suzuki, Keiko Yoshimoto, Yuko Kaneko, Yoshihiro Matsumoto, Kunihiro Yamaoka and Tsutomu Takeuchi Tags: Research article Source Type: research

Association of polymorphic variants in IL1B gene with secretion of IL-1 β protein and inflammatory markers in north Indian rheumatoid arthritis patients.
Association of polymorphic variants in IL1B gene with secretion of IL-1β protein and inflammatory markers in north Indian rheumatoid arthritis patients. Gene. 2017 Oct 17;: Authors: Jahid M, Rehan-Ul-Haq, Chawla D, Avasthi R, Ahmed RS Abstract The proinflammatory cytokine interleukin-1beta (IL-1β) is a key mediator of inflammation which affects cell proliferation and differentiation. IL-1β is considered to contribute to the pathophysiology of rheumatoid arthritis (RA). Polymorphisms in cytokine genes are highly influenced by ethnicity. Hence, in this study polymorphism of the IL1B-511(C...
Source: Gene - October 17, 2017 Category: Genetics & Stem Cells Authors: Jahid M, Rehan-Ul-Haq, Chawla D, Avasthi R, Ahmed RS Tags: Gene Source Type: research

Regulation of Arthritis Severity by the Acid Sphingomyelinase
Conclusion: We identified acid sphingomyelinase as a novel druggable target in rheumatoid arthritis. Functional inhibitors of acid sphingomyelinase have been clinically used for decades, are well tolerated and suitable for long-term treatment. They would be immediately available for clinical development as a novel rheumatoid arthritis therapy.Cell Physiol Biochem 2017;43:1460 –1471 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 16, 2017 Category: Cytology Source Type: research

Comparative evaluation of treatment patterns and healthcare utilization of newly diagnosed rheumatoid arthritis patients by anti-cyclic citrullinated peptide antibody status.
Authors: Lamerato L, Matthews K, Price K, Szymialis A, Eaddy M, Ogbonnaya A, Shih HC, Ahmad H Abstract BACKGROUND: Anti-cyclic citrullinated peptide (CCP) antibody positivity is an established diagnostic factor for severe disease activity and joint damage and a prognostic factor for aggressive disease in rheumatoid arthritis (RA). OBJECTIVE: To compare RA-related treatment, healthcare utilization, and joint erosion between anti-CCP-positive and anti-CCP-negative RA patients. METHODS: Newly diagnosed RA patients were identified from the Henry Ford Health System database between 1/1/2009 and 12/31/2014; the d...
Source: Journal of Medical Economics - October 16, 2017 Category: Health Management Tags: J Med Econ Source Type: research

Bradykinin system is involved in endometriosis ‐related pain through endothelin‐1 production
ConclusionsThe present study demonstrated the presence and the function of the BK axis in endometriosis, and established a potential new therapy target for endometriosis‐related pain. SignificanceThe present study demonstrated (1) the presence and the function of the BK system in endometriosis, (2) activation of BKR induced endothelin‐1 in endometriotic lesion and (3) blocking endothelin‐1 was effective to decrease pain. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2017 Category: Anesthesiology Authors: O. Yoshino, K. Yamada ‐Nomoto, M. Kobayashi, T. Andoh, M. Hongo, Y. Ono, A. Hasegawa‐Idemitsu, A. Sakai, Y. Osuga, S. Saito Tags: Original Article Source Type: research

Treatment Persistence and Healthcare Costs Among Patients with Rheumatoid Arthritis Changing Biologics in the USA
This study examined treatment persistence, cost, and cost per persistent patient among MOA switchers versus TNFi cyclers.MethodsThis study of Commercial and Medicare Advantage claims data from the Optum Research Database included patients with RA and at least one claim for a TNFi (adalimumab, certolizumab pegol, etanercept, golimumab, or infliximab) between January 2012 and September 2015 who changed to another TNFi or a different MOA therapy (abatacept, tocilizumab, or tofacitinib) within 1  year. The index date was the date of the change in therapy. Treatment persistence was defined as no subsequent switch or 60-day...
Source: Advances in Therapy - October 16, 2017 Category: Drugs & Pharmacology Source Type: research

A Bayesian model that jointly considers comparative effectiveness research and patients ’ preferences may help inform GRADE recommendations: An application to rheumatoid arthritis treatment recommendations
To estimate the preferred treatment for early rheumatoid arthritis (ERA) using a novel Bayesian approach that jointly considers patients ’ preferences and comparative effectiveness research (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 16, 2017 Category: Epidemiology Authors: Glen S. Hazlewood, Claire Bombardier, George Tomlinson, Deborah Marshall Source Type: research

GSE102728 IgG immunocomplexes sensitize human monocytes for inflammatory hyperactivity via transcriptomic and epigenetic reprogramming in autoimmune disease
We present here evidence that IgG ICs precipitated from RA sera sensitized human monocytes for a long-lasting inflammatory functional state characterized by a strong TNF α response to cellular proteins representing damage-associated molecular patterns (DAMPs) and microbe-derived pathogen-associated molecular patterns (PAMPs). Importantly, plate-coated human IgG (cIgG, a mimic of deposited IC without antigen restriction) exhibited similarly robust ability of monocyt e sensitization in vitro. The cIgG-induced functional programming is through FcγRIIa/Syk signaling and accompanied by characteristic phenotypic chan...
Source: GEO: Gene Expression Omnibus - October 15, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Interleukin-22 in human inflammatory diseases and viral infections
Publication date: Available online 14 October 2017 Source:Autoimmunity Reviews Author(s): Arezoo Gowhari Shabgah, Jamshid Gholizadeh Navashenaq, Omid Gohari Shabgah, Hamed Mohammadi, Amirhossein Sahebkar Interleukin-22 (IL22) is one of the members of IL10 family. Elevated levels of this cytokine can be seen in diseases caused by T lymphocytes, such as Psoriasis, Rheumatoid arthritis, interstitial lung diseases. IL22 is produced by different cells in both innate and acquired immunities. Different types of T cells are able to produce IL22, but the major IL22-producing T-cell is the TCD4. TH22 cell is a new line of TCD4 cell...
Source: Autoimmunity Reviews - October 15, 2017 Category: Allergy & Immunology Source Type: research

Autoimmune comorbidity in chronic spontaneous urticaria: a systematic review
Conclusions CSU patients have an increased risk of AIDs, especially adult female patients with a positive family history and a genetic predisposition for AIDs, who should be screened for signs and symptoms of AIDs. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - October 15, 2017 Category: Allergy & Immunology Source Type: research

Rheumatic diseases and autoimmune vascular dementia
Publication date: Available online 14 October 2017 Source:Autoimmunity Reviews Author(s): Fabiola Atzeni, Nicolò Pipitone, Luca Iaccarino, Ignazio Francesco Masala, Ronen Weiss, Alessandra Alciati, Andrea Doria, Joab Chapmanand, Piercarlo Sarzi-Puttini Vascular dementia (VD) comes second after Alzheimer’s disease (AD) as a cause of impaired cognition. VD is not a specific nosological entity, but rather a syndrome encompassing a number of diseases caused by impaired supply of blood to the brain. Systemic autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis and antiphospho...
Source: Autoimmunity Reviews - October 15, 2017 Category: Allergy & Immunology Source Type: research

‘Everyone assumes a man to be quite strong’: Men, masculinity and rheumatoid arthritis: A case‐study approach
Abstract Current literature has overlooked the impact of chronic illness on masculine identity. We therefore aimed to investigate the impact of rheumatoid arthritis (a long term condition, affecting more women than men) on masculine identity. Six focus groups with 22 men with rheumatoid arthritis (RA) (data reported elsewhere) followed by five one‐to‐one interviews with men (English, mean age: 59 years) sampled to reflect a heterogeneous experience of life with RA based on knowledge gained from the focus groups. Transcripts were analysed using thematic analysis and are presented as individual case studies. Whilst the c...
Source: Sociology of Health and Illness - October 15, 2017 Category: International Medicine & Public Health Authors: Caroline Flurey, Alan White, Karen Rodham, John Kirwan, Robert Noddings, Sarah Hewlett Tags: Original Article Source Type: research

The Relationship between the Serum Oxytocin Levels, Disease Activity, the ADLs and the QOL in Patients with Rheumatoid Arthritis.
Conclusion Although RA complicated by depression may be related to the following high disease activity, a poor QOL and poor ADLs, the serum OXT levels were not directly correlated. PMID: 29021442 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - October 14, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Drug-Induced Paradoxical Vocal Fold Motion
We present the clinical vignette of a 36-year-old woman with juvenile rheumatoid arthritis and multiple adverse drug reactions who presented with recurrent episodes of unrecognized PVFM during skin testing for drug allergy, omalizumab treatment, and tocilizumab desensitization. Before the diagnosis of PVFM, these episodes were treated as anaphylaxis, including the administration of epinephrine. Once diagnosed and treated for PVFM, the patient did not present any further events and continued treatment for drug allergy. PVFM may be underreported in hypersensitivity reactions because of the similarity to Type 1-mediated respi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 14, 2017 Category: Allergy & Immunology Source Type: research

Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study
This study aimed to analyze the effects of Tofacitinib treatment, a Janus kinase inhibitor, on atherosclerosis in patients with RA. Patients with an active RA (28-joint disease activity score –erythrocyte sedimentation rate>  3.2) despite methotrexate (MTX) treatment 12 mg/week were included in this open-label prospective study and started on Tofacitinib (10 mg/day, 5 mg twice/day). Japanese guideline does not allow high dose of MTX. All patients used a stable dosage of MTX, steroids, and statins or lipid-lowering d rugs. The primary endpoint was the comparison of the carotid intima-media thick...
Source: Rheumatology International - October 14, 2017 Category: Rheumatology Source Type: research

Treatment Outcomes with Biosimilars: Be Aware of the Nocebo Effect
AbstractOver the years, biologic agents have proven their importance in the management of chronic autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Biosimilars, which are biologic medicines, are highly similar to approved biologic medicines, and are comprehensively developed and rigorously tested to ensure efficacy and safety are similar to the reference product. A broader armamentarium of biosimilars is expected to improve patients ’ access to safe and effective biologic medicines, thus offering benefits to healthcare systems around the globe. Here we consider the factors ...
Source: Rheumatology and Therapy - October 14, 2017 Category: Rheumatology Source Type: research

The management of first-line biologic therapy failures in rheumatoid arthritis: Current practice and future perspectives
Publication date: Available online 14 October 2017 Source:Autoimmunity Reviews Author(s): Ennio Giulio Favalli, Maria Gabriella Raimondo, Andrea Becciolini, Chiara Crotti, Martina Biggioggero, Roberto Caporali The introduction of biologic disease–modifying anti-rheumatic drugs (bDMARDs) has dramatically changed the management of rheumatoid arthritis (RA). However, in a real-life setting about 30–40%. of bDMARD treated patients experience drug discontinuation because of either inefficacy or adverse events. According to international recommendations, to date the best strategy for managing first-line bDMARD failu...
Source: Autoimmunity Reviews - October 14, 2017 Category: Allergy & Immunology Source Type: research