Insight into the regulatory role of circRNA in angiogenesis and clinical implications
Angiogenesis is the physiological process of new blood vessel formation from existing capillary vessel or posterior capillary vein. Its dysfunction could result in a number of different kinds of diseases, such as cardiovascular diseases and cancer, contributing to death and disability worldwide. Circular RNAs (circRNAs) are a class of novel identified RNA molecules that have a special covalent loop structure without a 5 ′ cap and 3’ tail, which can form novel back-splicing or skipping events from precursor mRNAs. (Source: Atherosclerosis)
Source: Atherosclerosis - February 25, 2020 Category: Cardiology Authors: Yan Liu, Yanyan Yang, Zhibin Wang, Xiuxiu Fu, Xian-ming Chu, Yonghong Li, Qi Wang, Xingqiang He, Min Li, Kun Wang, Jian-xun Wang, Pei-feng Li, Tao Yu Tags: Review article Source Type: research

The association between erythrocyte membrane n-3 and n-6 polyunsaturated fatty acids and carotid atherosclerosis: A prospective study
The relationship of polyunsaturated fatty acids (PUFAs) with cardiovascular risk is still controversial. We aimed to determine whether erythrocyte n-3 and n-6 PUFAs are related to the risk of carotid atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - February 21, 2020 Category: Cardiology Authors: Ding Ding, Qing-wei Zhong, Shi-yuan Zuoluo, Chu-wen Ling, Feng Xiong, Yue-bin Ke, Yu-ming Chen Source Type: research

Practice of lipoprotein apheresis and short-term efficacy in children with homozygous familial hypercholesterolemia: Data from an international registry
Homozygous familial hypercholesterolemia (hoFH) may cause life-threatening atherosclerotic cardiovascular disease in childhood. Lipoprotein apheresis (LA) is considered a pivotal treatment option, but data on its efficacy, safety and optimal performance are limited. We therefore established an international registry on the execution and outcomes of LA in HoFH children. Here we report LA policies and short-term outcomes. (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2020 Category: Cardiology Authors: Luirink Ik, Barbara A. Hutten, Susanne Greber-Platzer, Genovefa D. Kolovou, Eldad J. Dann, Sarah D. de Ferranti, Christina Taylan, Eric Bruckert, Samir Saheb, Jun Oh, Joenna Driemeyer, Michel Farnier, Lars Pape, Claus P. Schmitt, Francisco J. Novoa, Marti Source Type: research

Oxidized low-density lipoprotein (LDL) and LDL cholesterol are associated with outcomes of minor stroke and TIA
Low-density lipoprotein (LDL) and oxidized low-density lipoprotein (oxLDL) levels are thought to be related to recurrent stroke. However, the joint association of circulating LDL and oxLDL levels with the outcomes of acute minor ischemic stroke and transient ischemic attack (TIA) remains unclear. The goal of the study was to evaluate whether LDL and oxLDL have a combined effect on outcomes of acute minor stroke and TIA. (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2020 Category: Cardiology Authors: Anxin Wang, Liye Dai, Nan Zhang, Jinxi Lin, Guojuan Chen, Yingting Zuo, Hao Li, Yilong Wang, Xia Meng, Yongjun Wang Source Type: research

Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers
E-cigarette use is increasingly common. Whether e-cigarettes are harmful to human health is an intensely debated subject. In order to investigate whether e-cigarettes with and without nicotine cause different vascular responses, we obtained blood samples from healthy young volunteers who performed brief active e-cigarette inhalations. Extracellular vesicles (EVs) of endothelial and platelet origin were measured to determine vascular changes. (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2020 Category: Cardiology Authors: Fariborz Mobarrez, Lukasz Antoniewicz, Linnea Hedman, Jenny A. Bosson, Magnus Lundb äck Source Type: research

Nuclear receptors in abdominal aortic aneurysms
Abdominal aortic aneurysms (AAA) pose a considerable health burden and at present are only managed surgically since there is no proven pharmacotherapy that will retard their expansion or reduce the incidence of fatal rupture. This pathology shares several pathophysiological mechanisms with atherosclerosis, such as macrophage infiltration, inflammation, and degradation of extracellular matrix. Therefore, therapeutic targets proven effective in the treatment of atherosclerosis could also be considered for treatment of AAA. (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2020 Category: Cardiology Authors: Jaap G. Neels, R éda Hassen-Khodja, Giulia Chinetti Tags: Review article Source Type: research

18Fluoride-based molecular imaging of coronary atherosclerosis in HIV infected patients
Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques. (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2020 Category: Cardiology Authors: Giovanni Guaraldi, Jovana Milic, Napoleone Prandini, Guido Ligabue, Francesco Esposito, Giacomo Ciusa, Andrea Malagoli, Riccardo Scaglioni, Giulia Besutti, Barbara Beghetto, Giulia Nardini, Enrica Roncaglia, Cristina Mussini, Paolo Raggi Source Type: research

Cholesterol mass efflux capacity and risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis
We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD). (Source: Atherosclerosis)
Source: Atherosclerosis - February 15, 2020 Category: Cardiology Authors: Parveen K. Garg, Neal W. Jorgensen, Robyn L. McClelland, Matthew Allison, James H. Stein, Laurent Yvan-Chavret, Alan R. Tall, Steven Shea Source Type: research

Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease
The accumulation of acquired mutations is an inevitable consequence of the aging process, but its pathophysiological relevance has remained largely unexplored beyond cancer. Most of these mutations have little or no functional consequences, but in a few rare instances, a mutation may arise that confers a competitive advantage to a stem cell, leading to its clonal expansion. When such a mutation occurs in hematopoietic stem cells, it leads to a situation of clonal hematopoiesis, which has the potential to affect multiple tissues beyond the bone marrow, as the clonal expansion of the mutant stem cell is extended to circulati...
Source: Atherosclerosis - February 15, 2020 Category: Cardiology Authors: Marta Amor ós-Pérez, José J. Fuster Tags: Review article Source Type: research

Antithrombotic agents for primary and secondary prevention of cardiovascular events in patients with end-stage renal disease on chronic hemodialysis
Cardiovascular disease (CVD) is common in patients with end-stage renal disease (ESRD) on hemodialysis (HD). However, antithrombotic therapy to prevent CVD increases the risk of bleeding. We aimed to investigate the prevalence of CVD and the practice patterns of antithrombotic agents in patients with ESRD on HD. (Source: Atherosclerosis)
Source: Atherosclerosis - February 15, 2020 Category: Cardiology Authors: Oliver K önigsbrügge, Sabine Schmaldienst, Martin Auinger, Renate Klauser-Braun, Matthias Lorenz, Susanne Tabernig, Josef Kletzmayr, Brigitte Enzenberger, Manfred Eigner, Manfred Hecking, Jolanta M. Siller-Matula, Ingrid Pabinger, Marcus Säemann, Cihan Source Type: research

Risk of peripheral arterial disease in patients with periodontitis: A nationwide, population-based, matched cohort study
The association between coronary heart disease (CHD) caused by atherosclerosis and periodontitis has already been established. Peripheral arterial disease (PAD) is also caused by atherosclerosis, but the characteristics of the target artery and the disease are different from those of CHD. The aim of this study was to determine whether the risk of PAD was high in patients with periodontitis. (Source: Atherosclerosis)
Source: Atherosclerosis - February 15, 2020 Category: Cardiology Authors: Dong-Hyuk Cho, In-Seok Song, Jimi Choi, Jun Gyo Gwon Source Type: research

Human microRNA-140-5p down-regulates LDL receptor and attenuates LDL-C uptake in human hepatocytes
This study aimed to identify novel miRs that regulate LDLR expression. (Source: Atherosclerosis)
Source: Atherosclerosis - February 14, 2020 Category: Cardiology Authors: Yaqiong Xu, Jie Gao, Yaqin Gong, Manman Chen, Jiali Chen, Wenfeng Zhao, Shuhua Tan Source Type: research

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies
Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change. (Source: Atherosclerosis)
Source: Atherosclerosis - February 14, 2020 Category: Cardiology Authors: Mary F. Feitosa, Kathryn L. Lunetta, Lihua Wang, Mary K. Wojczynski, Candace M. Kammerer, Thomas Perls, Nicole Schupf, Kaare Christensen, Joanne M. Murabito, Michael A. Province Source Type: research

Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study
Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics. (Source: Atherosclerosis)
Source: Atherosclerosis - February 13, 2020 Category: Cardiology Authors: Minna K. Karjalainen, Michael V. Holmes, Qin Wang, Olga Anufrieva, Mika K ähönen, Terho Lehtimäki, Aki S. Havulinna, Kati Kristiansson, Veikko Salomaa, Markus Perola, Jorma S. Viikari, Olli T. Raitakari, Marjo-Riitta Järvelin, Mika Ala-Korpela, Johann Source Type: research

An oxide transport chain essential for balanced insulin action
Patients with overnutrition, obesity, the atherometabolic syndrome, and type 2 diabetes typically develop fatty liver, atherogenic dyslipoproteinemia, hyperglycemia, and hypertension. These features share an unexplained origin – namely, imbalanced insulin action, also called pathway-selective insulin resistance and responsiveness. To control glycemia, these patients require hyperinsulinemia that then overdrives ERK and hepatic de-novo lipogenesis. We previously reported that NADPH oxidase-4 regulates balanced insulin ac tion, but the model appeared incomplete. (Source: Atherosclerosis)
Source: Atherosclerosis - February 13, 2020 Category: Cardiology Authors: Xiangdong Wu, Keyang Chen, Kevin Jon Williams Source Type: research

The PGC-1 α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis
Atherosclerosis (AS) is the leading cause of cardiovascular diseases. PGC-1 α is a key regulator of cellular energy homeostasis, but its role in AS remains debatable. (Source: Atherosclerosis)
Source: Atherosclerosis - February 8, 2020 Category: Cardiology Authors: Hoshun Chong, Zhe Wei, Namuhan, Gongrui Sun, Shasha Zheng, Xiyu Zhu, Yunxing Xue, Qing Zhou, Shanjun Guo, Jinhong Xu, Haoquan Wang, Le Cui, Chen-Yu Zhang, Xiaohong Jiang, Dongjin Wang Source Type: research

The impact of helical flow on coronary atherosclerotic plaque development
Atherosclerosis has been associated with near wall hemodynamics and wall shear stress (WSS). However, the role of coronary intravascular hemodynamics, in particular of the helical flow (HF) patterns that physiologically develop in those arteries, is rarely considered.The purpose of this study was to assess how HF affects coronary plaque initiation and progression, definitively demonstrating its atheroprotective nature. (Source: Atherosclerosis)
Source: Atherosclerosis - February 7, 2020 Category: Cardiology Authors: Giuseppe De Nisco, Ayla Hoogendoorn, Claudio Chiastra, Diego Gallo, Annette M. Kok, Umberto Morbiducci, Jolanda J. Wentzel Source Type: research

Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice
Inflammation, oxidative stress, matrix degradation, medial calcification and vascular smooth muscle cell (VSMC) loss are prominent features in abdominal aortic aneurysm (AAA). VSMC phenotypic switch to a proinflammatory state and VSMC apoptosis could be targetable mechanisms implicated in the pathogenesis of AAA formation. Herein, we investigated the hypothesis that a xanthine derivative (KMUP-3) might suppress AAA through inhibition of VSMC phenotypic switch and apoptosis. (Source: Atherosclerosis)
Source: Atherosclerosis - February 6, 2020 Category: Cardiology Authors: Chao-Han Lai, Ching-Wen Chang, Fang-Tzu Lee, Cheng-Hsiang Kuo, Jong-Hau Hsu, Chung-Pin Liu, Hua-Lin Wu, Jwu-Lai Yeh Source Type: research

Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophage
In this study, regulation of HDL biogenesis by NOB was investigated modulating ABCA1 and ABCG1 expression. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2020 Category: Cardiology Authors: Tomoe Tsuboi, Rui Lu, Takayuki Yonezawa, Akio Watanabe, Je-Tae Woo, Sumiko Abe-Dohmae, Shinji Yokoyama Source Type: research

Serum uromodulin and risk for cardiovascular morbidity and mortality in the community-based KORA F4 study
Serum uromodulin, a novel biomarker of kidney function and tubular integrity, has been linked to cardiovascular events and total mortality in patients at high cardiovascular risk. Here, we analyze the association of serum uromodulin with cardiovascular morbidity and cardiovascular as well as total mortality in the population-based KORA F4 study stratified by sex. (Source: Atherosclerosis)
Source: Atherosclerosis - February 4, 2020 Category: Cardiology Authors: Cornelia Then, Holger L. Then, Andreas Lechner, Barbara Thorand, Christa Meisinger, Margit Heier, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, J ürgen Scherberich, Jochen Seissler Source Type: research

How many more data is required to give the kidney the attention it deserves? Time to act for the “Big Five” of cardiovascular disease
“Do you know your numbers?” became a very frequently asked question over the last decades. Shortly after Christmas, the meaning of this question digs like a bulldozer into our brain when we try to avoid to step on the scale assuming that nothing good can be expected. However, it has a much broad er sense than just body weight. Numerous campaigns have tried to train people to be aware about classical cardiovascular risk factors, which can be measured on a continuous scale such as cholesterol, blood pressure, blood glucose, body mass index or waist circumference. (Source: Atherosclerosis)
Source: Atherosclerosis - February 2, 2020 Category: Cardiology Authors: Florian Kronenberg, Gerit-Holger Schernthaner Tags: Editorial Source Type: research

Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - February 1, 2020 Category: Cardiology Source Type: research

Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm
In this study, we investigated the effects of another ADAM protein (ADMA9) in AAA formation. (Source: Atherosclerosis)
Source: Atherosclerosis - January 31, 2020 Category: Cardiology Authors: Guanghui Shen, Qingfeng Sun, Ye Yao, Shiyong Li, Gaoyan Liu, Chao Yuan, Haocheng Li, Yiyan Xu, Haiyang Wang Source Type: research

LIPA gene mutations affect the composition of lipoproteins: Enrichment in ACAT-derived cholesteryl esters
Cholesteryl ester storage disease (CESD) due to LIPA gene mutations is characterized by hepatic steatosis, hypercholesterolemia and hypoalphalipoproteinemia, exposing affected patients to an increased cardiovascular risk. Further insights into the impact of LIPA gene mutations on lipid/lipoprotein metabolism are limited. Aim of the study was to investigate the effect of carrying one or two mutant LIPA alleles on lipoprotein composition and function. (Source: Atherosclerosis)
Source: Atherosclerosis - January 31, 2020 Category: Cardiology Authors: Lorenzo Arnaboldi, Alice Ossoli, Eleonora Giorgio, Livia Pisciotta, Tiziano Lucchi, Liliana Grigore, Chiara Pavanello, Agnese Granata, Andrea Pasta, Beatrice Arosio, Domenico Azzolino, Andrea Baragetti, Samuela Castelnuovo, Alberto Corsini, Alberico L. Ca Source Type: research

Early onset of menopause is associated with increased peripheral atherosclerotic plaque volume and progression
Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV). (Source: Atherosclerosis)
Source: Atherosclerosis - January 31, 2020 Category: Cardiology Authors: Michael Schreinlechner, Maria Noflatscher, Sebastian Johannes Reinstadler, Philip Sommer, Daniela Lener, Elisabeth Reiser, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Peter Marschang Source Type: research

Endothelial dysfunction and arterial stiffness in patients with systemic lupus erythematosus: A systematic review and meta-analysis
Non-invasive surrogates of cardiovascular (CV) disease such as endothelial dysfunction (ED) and peripheral arterial stiffness (AS) have been evaluated in systemic lupus erythematosus (SLE) patients. The aim of this study was to systematically review and meta-analyze reports of cardiovascular disease (CVD) in SLE patients, as measured by ED and AS. (Source: Atherosclerosis)
Source: Atherosclerosis - January 31, 2020 Category: Cardiology Authors: Claudia Mendoza-Pinto, Adriana Rojas-Villarraga, Nicol ás Molano-González, Mario García-Carrasco, Pamela Munguía-Realpozo, Ivet Etchegaray-Morales, Héctor Morales-Sánchez, Roberto Berra-Romani, Ricard Cervera Source Type: research

Probucol-induced hypocholesterolemia is not associated with exacerbated foam cell formation in ABCG1 knockout mice
We have recently published in Atherosclerosis that the regression capacity of established atherosclerotic lesions is diminished by treatment of mice with the lipid-lowering drug probucol [1]. Yamamoto et al. have shown that probucol treatment in wild-type mice does not diminish the flux of cholesterol from lipid-laden macrophages back to the liver and feces (reverse cholesterol transport) [2]. We thus anticipated that the probucol effect was primarily related to lowering of plasma high-density lipoprotein (HDL) levels, resulting from the disruption of ATP-binding cassette transporter A1 (ABCA1) function in hepatocytes. (So...
Source: Atherosclerosis - January 30, 2020 Category: Cardiology Authors: Menno Hoekstra, Miranda Van Eck Tags: Correspondence Source Type: research

Association of variability in uric acid and future clinical outcomes of patient with coronary artery disease undergoing percutaneous coronary intervention
Hyperuricemia is independently associated with cardiovascular disease (CVD) and is considered to be one of the major risk factors for CVD. However, the impact of inter-visit uric acid (UA) variability on cardiovascular risk remains undetermined. (Source: Atherosclerosis)
Source: Atherosclerosis - January 30, 2020 Category: Cardiology Authors: Su Shen Lim, Ya-Ling Yang, Su-Chan Chen, Cheng-Hsueh Wu, Shao-Sung Huang, Wan Leong Chan, Shing-Jong Lin, Jaw-Wen Chen, Chia-Yu Chou, Pan Ju-Pin, Min-Ji Charng, Ying-Hwa Chen, Tao-Cheng Wu, Tse-Min Lu, Pai-Feng Hsu, Po-Hsun Huang, Hao-Min Cheng, Chin-Chou Source Type: research

Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal
Calcium is the most abundant mineral in the human body. Approximately 99% of the total body calcium is present, in form of hydroxyapatite – a lattice-like crystal composed of calcium, phosphorus, and hydroxide – in bones and teeth, where it essentially plays a structural role. The remaining calcium is in the extracellular fluid and in various tissues, where it regulates numerous processes, including vascular tone, muscle contracti on-dilation, nerve impulse transmission, intracellular signaling, ATP production, and hormonal secretion. (Source: Atherosclerosis)
Source: Atherosclerosis - January 28, 2020 Category: Cardiology Authors: Marco B. Morelli, Gaetano Santulli, Jessica Gambardella Tags: Editorial Source Type: research

Methodological issues regarding: “A third of nonfasting plasma cholesterol is in remnant lipoproteins: Lipoprotein subclass profiling in 9293 individuals”
We read with great interest the recent article by Balling et al. [1] on lipoprotein subclass profiling in 9293 individuals with mean triglycerides of 1.8 mmol/L concluding that “using direct measurements, one-third of total cholesterol in plasma was present in remnant lipoproteins”. Although we agree with the larger point that remnant cholesterol may contribute significantly to the residual risk of cardiovascular disease, we believe that the nuclear magnetic resonance (NMR) spectroscopy measurements performed for this paper using the Nightingale Health platform ( led t...
Source: Atherosclerosis - January 27, 2020 Category: Cardiology Authors: Alan T. Remaley, James D. Otvos Tags: Correspondence Source Type: research

Legumain in cardiovascular disease: Culprit or ally?
Atherosclerosis is well established as a complex process that involves vascular cells, lipid buildup and inflammatory mediators. Their relative contribution varies during different stages of atherosclerosis - from the first appearance of fatty streaks to rupture-prone atherosclerotic plaques [1]. Besides the adaptive immune systems and its constituents, monocytes and macrophages have been shown to be instrumental from early atherogenesis to plaque rupture. In addition to their classical phagocytic properties that may result in their transition into foam cells, macrophages can also release a plethora of cytokines and enzyme...
Source: Atherosclerosis - January 23, 2020 Category: Cardiology Authors: Saskia C. de Jager, Imo E. Hoefer Tags: Editorial Source Type: research

T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration
This study aimed to investigate the potential effects of Tdag8 in VSMCs during atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2020 Category: Cardiology Authors: Lian-Di Chen, Wen-Ting Zhu, Yuan-Yuan Cheng, Zhen-Hua Li, Yi-Qing Chen, Zhong-Wen Yuan, Cai-Yan Lin, Dong-Dong Jing, Zhong-Qiu Liu, Peng-Ke Yan Source Type: research

Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis
Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - January 21, 2020 Category: Cardiology Authors: Xiangyuan Pu, Kenneth Chan, Wei Yang, Qingzhong Xiao, Li Zhang, Andrew D. Moore, Chuanju Liu, Tom R. Webb, Mark J. Caulfield, Nilesh J. Samani, Jianhua Zhu, Shu Ye Source Type: research

Risk of acute mesenteric ischemia in patients with diabetes: A population-based cohort study in Taiwan
Diabetes is a common and complex endocrine disorder that often results in hyperglycemia, which has been strongly implicated in several cardiovascular and cerebrovascular events that cause disability. Acute mesenteric ischemia (AMI) is a vascular emergency with high mortality rates. We conducted a population-based cohort study that utilizes data from medical claims databases to investigate whether diabetes increases the risk of AMI. (Source: Atherosclerosis)
Source: Atherosclerosis - January 21, 2020 Category: Cardiology Authors: Yen-Wei Chiu, Chi-Shin Wu, Pei-Chun Chen, Yu-Chung Wei, Le-Yin Hsu, Shi-Heng Wang Source Type: research

Outcomes of lipid control in secondary prevention of coronary artery disease in Finland: A 24-month follow-up after acute coronary syndrome
The objective of this study is to evaluate the LDL cholesterol (LDL-C) levels as outcomes of secondary prevention of CAD in Finland up to 24 months after being diagnosed with acute coronary syndrome (ACS). This retrospective analysis of patients with ACS was conducted in two areas of Finland that have a combined population of 400,000. (Source: Atherosclerosis)
Source: Atherosclerosis - January 21, 2020 Category: Cardiology Authors: Riikka-Leena Leskel ä, Anna Torvinen, Tuomas T. Rissanen, Vesa Virtanen, Fredrik Herse, Mikko Nuutinen, Juha Mustonen, Tiina Laatikainen Source Type: research

Comments on “The ketogenic diet: Pros and cons”
“In all debates, let truth be thy aim, not victory, or an unjust interest.”,William Penn (Source: Atherosclerosis)
Source: Atherosclerosis - January 20, 2020 Category: Cardiology Authors: William Dafoe, Gabor T. Gyenes Tags: Correspondence Source Type: research

Impact of hepatitis C virus clearance by direct-acting antiviral treatment on the incidence of major cardiovascular events: A prospective multicentre study
HCV is associated with an increased risk of cardiovascular events (CV). Whether HCV clearance by direct-acting antivirals (DAA) reduces incident CV disease is poorly understood. We investigate whether HCV eradication reduces CV events. (Source: Atherosclerosis)
Source: Atherosclerosis - January 20, 2020 Category: Cardiology Authors: Luigi Elio Adinolfi, Salvatore Petta, Anna Ludovica Fracanzani, Carmine Coppola, Vincenzo Narciso, Riccardo Nevola, Luca Rinaldi, Vincenza Calvaruso, Laura Staiano, Vito Di Marco, Aldo Marrone, Pia Clara Pafundi, Antonio Solano, Rosa Lombardi, Ferdinando Source Type: research

Comment on: “High released lactate by epicardial fat from coronary artery disease patients is reduced by dapagliflozin treatment”
We read with interest the article by Couselo-Seijas et al. “High released lactate by epicardial fat from coronary artery disease patients is reduced by dapagliflozin treatment” [1]. The use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors (SGLT-2i) is gradually increasing in diabetes mellitus (DM) and heart failure treatment. Increasing pieces of n ovel information are added to the literature on these drugs. We strongly agree with the authors' findings. The article has led us to consider lactate levels in euglycemic (E) diabetic ketoacidosis (DKA) due to SGLT2i use, and the usefulness of metformin and SGLT...
Source: Atherosclerosis - January 19, 2020 Category: Cardiology Authors: Erkan Cure Tags: Correspondence Source Type: research

Risk for cardiovascular events responds nonlinearly to carotid intima-media thickness in the KORA F4 study
Risk assessment studies on the impact of carotid intima-media thickness (CIMT) on cardiovascular events (CVEs) often apply a linear relationship in Cox models of proportional hazards. However, CVEs are mostly induced through rupture of plaques driven by nonlinear mechanical properties of the arterial wall. Hence, the risk response might be nonlinear as well and should be detectable in CVE incidence data when associated with CIMT as surrogate variable for atherosclerotic wall degeneration. (Source: Atherosclerosis)
Source: Atherosclerosis - January 19, 2020 Category: Cardiology Authors: Cristoforo Simonetto, Margit Heier, Susanne Rospleszcz, Christa Meisinger, Cornelia Then, Jochen Sei ßler, Annette Peters, Jan Christian Kaiser Source Type: research

A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility
The insulin-like growth factor (IGF)-1 signalling pathway has been implicated in the pathogenesis of atherosclerosis; however, the mechanism underlying its role in stroke remains unexplained. Herein, we aimed to explore the effects of genetic polymorphisms in the IGF1 pathway on stroke in the Chinese Han population. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2020 Category: Cardiology Authors: Yingshui Yao, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Chong Shen Source Type: research

The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb: A meta-analysis and a longitudinal evaluation
Genetic loci associated with CHD show different relationships with the intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2020 Category: Cardiology Authors: Lars Lind, Bruna Gigante, Yan Borne, Anders M älarstig, Johan Sundström, Johan Ärnlöv, Erik Ingelsson, Damiano Baldassarre, Elena Tremoli, Fabrizio Veglia, Anders Hamsten, Marju Orho-Melander, Jan Nilsson, Olle Melander, Gunnar Engström Source Type: research

Abdominal aortic calcification (AAC) and ankle-brachial index (ABI) predict health care costs and utilization in older men, independent of prevalent clinical cardiovascular disease and each other
Abdominal aortic calcification (AAC) and low ankle-brachial index (ABI) are markers of multisite atherosclerosis. We sought to estimate their associations in older men with health care costs and utilization adjusted for each other, and after accounting for CVD risk factors and prevalent CVD diagnoses. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2020 Category: Cardiology Authors: John T. Schousboe, Tien N. Vo, Lisa Langsetmo, Selcuk Adabag, Pawel Szulc, Joshua R. Lewis, Allyson M. Kats, Brent C. Taylor, Kristine E. Ensrud Source Type: research

Association of diabetes with outcomes in patients undergoing contemporary percutaneous coronary intervention: Pre-specified subgroup analysis from the randomized GLOBAL LEADERS study
Diabetes has been well recognized as a strong predictor for adverse outcomes after percutaneous coronary intervention (PCI), however, studies in the era of drug-eluting stent and potent P2Y12 inhibitors have shown conflicting results. We aimed to assess ischemic and bleeding outcomes after contemporary PCI according to diabetic status. (Source: Atherosclerosis)
Source: Atherosclerosis - January 15, 2020 Category: Cardiology Authors: Ply Chichareon, Rodrigo Modolo, Norihiro Kogame, Kuniaki Takahashi, Chun-Chin Chang, Mariusz Tomaniak, Roberto Botelho, Eric Eeckhout, Sjoerd Hofma, Diana Trendafilova-Lazarova, Zsolt K őszegi, Andres Iñiguez, Joanna Wykrzykowska, Jan J. Piek, Scot Garg Source Type: research

Corrigendum to “Lipoprotein apheresis efficacy, challenges and outcomes: A descriptive analysis from the UK Lipoprotein Apheresis Registry, 1989–2017” [Atherosclerosis 290 (November 2019) 44–51]
The Authors regret that there is a repetitive error in Table 4 with regards to the use of the term “baseline”. Under the Factors TC, LDL-C and Lp(a) the fourth row sub-headings should read “% ↓ C interval mean vs TC, LDL and Lp(a) off treatment” not “% ↓ C interval mean vs baseline TC, LDL and Lp(a).” (Source: Atherosclerosis)
Source: Atherosclerosis - January 13, 2020 Category: Cardiology Authors: Alison Pottle, Gilbert Thompson, Mahmoud Barbir, Graham Bayly, Jaimini Cegla, Robert Cramb, Tina Dawson, Ruth Eatough, Vaishali Kale, Clare Neuwirth, Kirsty Nicholson, Jules Payne, James Scott, Handrean Soran, Shahenaz Walji, Suzanne Watkins, Hazel Weedon Source Type: research

Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM
The joint consensus panel of the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) recently addressed present and future challenges in the laboratory diagnostics of atherogenic lipoproteins. Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and calculated non-HDL cholesterol (=total – HDL cholesterol) constitute the primary lipid panel for estimating risk of atherosclerotic cardiovascular disease (ASCVD) and can be measured in the nonfasting state. (Source: Atherosclerosis)
Source: Atherosclerosis - January 13, 2020 Category: Cardiology Authors: B ørge G. Nordestgaard, Michel R. Langlois, Anne Langsted, M. John Chapman, Kristin M. Aakre, Hannsjörg Baum, Jan Borén, Eric Bruckert, Alberico Catapano, Christa Cobbaert, Paul Collinson, Olivier S. Descamps, Christopher J. Duff, Arnold von Eckardstei Tags: Review article Source Type: research

Development of a novel score to predict newly diagnosed atrial fibrillation after ischemic stroke: The CHASE-LESS score
Prompt detection of atrial fibrillation (AF) is essential for optimal secondary stroke prevention, but routine long-term cardiac monitoring of all ischemic stroke patients is neither practical nor affordable. We aimed to develop and validate a risk score to identify patients at risk for newly diagnosed AF (NDAF) after ischemic stroke. (Source: Atherosclerosis)
Source: Atherosclerosis - January 13, 2020 Category: Cardiology Authors: Hsieh Cheng-Yang, Lee Cheng-Han, Sung Sheng-Feng Source Type: research

Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection
Dietary long-chain ( ≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknown. (Source: Atherosclerosis)
Source: Atherosclerosis - January 12, 2020 Category: Cardiology Authors: Zhan Wang, Russel C. Sequeira, Manal Zabalawi, Jennifer Madenspacher, Elena Boudyguina, Tiantong Ou, Jonathan M. Nelson, Yan Nie, Qingxia Zhao, Michael B. Fessler, Xuewei Zhu Source Type: research

Progression of coronary calcium burden and carotid stiffness in patients with essential thrombocythemia associated with JAK2 V617F mutation
Patients with myeloproliferative neoplasms often succumb to cardiovascular events, but little is known on the early stages of their vascular disease. We studied how patients with JAK2 V617F positive essential thrombocythemia (ET) without overt atherosclerotic disease differed from control subjects in progression of carotid artery stiffness and preclinical atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2020 Category: Cardiology Authors: Ajda An žič Drofenik, Matjaž Vrtovec, Mojca Božič Mijovski, Matjaž Sever, Irena Preložnik Zupan, Nataša Kejžar, Aleš Blinc Source Type: research

Long non-coding RNA LOC285194 regulates vascular smooth muscle cell apoptosis in atherosclerosis.
Abstract Long non-coding RNAs (lncRNAs) recently have been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown. Here we identified LOC285194 as a key regulator of cell proliferation and apoptosis during atherosclerosis. The expression of LOC285194 was dramatically down-regulated in a aortic atherosclerotic plaques of well-defined model of apolipoprotein-E knockout (ApoE-/-) mice. Moreover, we found that targeting LOC285194 results in neointimal hyperplasia in vivo in ca...
Source: Atherosclerosis - January 1, 2020 Category: Cardiology Authors: Cheng Q, Zhang M, Zhang M, Ning L, Chen D Tags: Bioengineered Source Type: research