Isolated superior mesenteric artery dissection with concomitant vascular aberrancy: Extremely rare cases and clinical implications
CONCLUSION: Vascular aberrancy may be a new identified risk factor for ISMAD. Even in ISMAD cases with vascular aberrancy, conservative treatment still can be used as first line therapy.PMID:38664953 | DOI:10.1177/17085381241251426 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Lei Dou Bin Zhang Hao Tang Huiyuan Yang Lei Liu Source Type: research
C-reactive Protein: An Inflammatory Biomarker and a Predictor of Neurodegenerative Disease in Patients With Inflammatory Bowel Disease?
Cureus. 2024 Apr 25;16(4):e59009. doi: 10.7759/cureus.59009. eCollection 2024 Apr.ABSTRACTInflammatory bowel disease (IBD) refers to two chronic conditions of the digestive tract: ulcerative colitis (UC) and Crohn's disease (CD), representing a progressive inflammatory process that mainly occurs in the gut, with frequent extra-intestinal manifestations. Even if remission is periodically obtained for some patients, the histological activity and digestive symptoms may continue, maintaining a persistent systemic inflammation that could induce further extra-intestinal complications and contribute to the development of neurodeg...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Simona Muresan Mark Slevin Source Type: research
Cerebral Aneurysm Characteristics and Surgical Outcomes: An In-Depth Analysis of 346 Cases Operated Using Microsurgical Clipping
Cureus. 2024 Mar 26;16(3):e56933. doi: 10.7759/cureus.56933. eCollection 2024 Mar.ABSTRACTThis comprehensive study analyzes 346 surgically treated intracranial aneurysms, emphasizing the importance of understanding risk factors and prevalent characteristics in patients. Intracranial aneurysms, primarily of the saccular or berry type, significantly contribute to nontraumatic subarachnoid hemorrhages and demonstrate a rising incidence due to advances in imaging techniques. The study highlights a gender discrepancy in aneurysm occurrence and a higher prevalence in individuals over 30 years old. The research delves into variou...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Corneliu Toader Cristian Kakucs Nicolaie Dobrin Razvan-Adrian Covache-Busuioc Bogdan-Gabriel Bratu Andrei Adrian Popa Luca-Andrei Glavan Antonio-Daniel Corlatescu Matei George Nicolae Grama Horia-Petre Costin Alexandru Vladimir Ciurea Source Type: research
Bioinformatic Identification of Hub Genes Related to Menopause-Obesity Paradox in Breast Cancer
CONCLUSIONS: These results may improve our understanding of the underlying mechanisms of the effects of body mass on BC and assist in identifying biomarkers and potential therapeutic targets for treating obese postmenopausal women with BC.PMID:38666041 | PMC:PMC11041819 | DOI:10.5812/ijem-140835 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Zahra Hosseinpour Mostafa Rezaei-Tavirani Mohammad Esmaeil Akbari Source Type: research
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases
Metab Syndr Relat Disord. 2024 Apr 26. doi: 10.1089/met.2024.0013. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER), the center of protein folding, also controls the cell's life-and-death signaling mechanisms. ER stress caused by unfolded or misfolded proteins leads to the activation of the unfolded protein response (UPR) in the cell. The UPR utilizes three main signaling pathways to restore disrupted ER homeostasis. These signaling pathways are protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1, and activating transcription factor 6. Studies have reported that ER stress (ERS) plays...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Firdevs Sak Fatma Sengul Husamettin Vatansev Source Type: research
The Interplay of Microbiome Dysbiosis and Cardiovascular Disease
Cardiol Rev. 2024 Apr 26. doi: 10.1097/CRD.0000000000000701. Online ahead of print.ABSTRACTThe intricate ecosystem of the mammalian gut, which hosts a diverse microbiome, plays a vital role in various physiological functions. Trillions of bacteria within the gut contribute to host metabolism, immune modulation, energy homeostasis, and more. Emerging research highlights the gut microbiota's significant impact on cardiovascular diseases (CVDs), with intestinal dysbiosis identified as a risk factor for conditions such as obesity and diabetes, both linked to atherosclerosis. Chronic inflammation, pivotal in atherosclerosis, is...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Anas Zaher Jude Elsaygh Stephen J Peterson Ilan S Weisberg Manish A Parikh William H Frishman Source Type: research
A Novel Artificial Coronary Plaque to Model Coronary Heart Disease
CONCLUSION: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.PMID:38667208 | DOI:10.3390/biomimetics9040197 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Philipp Lindenhahn Jannik Richter Iliyana Pepelanova Bettina Seeger Holger A Volk Rabea Hinkel Bernhard Hiebl Thomas Scheper Jan B Hinrichs Lena S Becker Axel Haverich Tim Kaufeld Source Type: research
The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition
Cells. 2024 Apr 9;13(8):658. doi: 10.3390/cells13080658.ABSTRACTVascular smooth muscle cells (VSMCs), in their contractile and differentiated state, are fundamental for maintaining vascular function. Upon exposure to cholesterol (CHO), VSMCs undergo dedifferentiation, adopting characteristics of foam cells-lipid-laden, macrophage-like cells pivotal in atherosclerotic plaque formation. CHO uptake by VSMCs leads to two primary pathways: ABCA1-mediated efflux or storage in lipid droplets as cholesterol esters (CEs). CE formation, involving the condensation of free CHO and fatty acids, is catalyzed by sterol O-acyltransferase ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Bethany J Bogan Holly C Williams Claire M Holden Vraj Patel Giji Joseph Christopher Fierro Hugo Sepulveda W Robert Taylor Amir Rezvan Alejandra San Martin Source Type: research
Non-Invasive Assessment of Micro- and Macrovascular Function after Initiation of JAK Inhibitors in Patients with Rheumatoid Arthritis
CONCLUSIONS: Three-month treatment with JAK inhibitors may exert significant effects on microcirculation as assessed with nailfold videocapillaroscopy, whereas macrovascular structure and function appears largely unaffected. Further research toward this direction may add substantial information to the available literature regarding cardiovascular aspects of JAK inhibitors in RA.PMID:38667479 | DOI:10.3390/diagnostics14080834 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Panagiota Anyfanti Elena Angeloudi Athanasia Dara Eleni Pagkopoulou Georgia-Savina Moysidou Kleopatra Deuteraiou Maria Boutel Eleni Bekiari Michael Doumas George D Kitas Theodoros Dimitroulas Source Type: research
Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study
J Cardiovasc Dev Dis. 2024 Apr 16;11(4):121. doi: 10.3390/jcdd11040121.ABSTRACTThe main goal of this study was to assess whether the presence of peripheral arterial disease (PAD) correlates with increased inflammatory cell infiltration. An observational, single-centre, and prospective study was conducted from January 2018 to July 2022. Clinical characteristics and anthropometric measures were registered. Consecutive PAD patients with surgical indications for a common femoral artery approach and patients with varicose veins with an indication for surgical ligation of the saphenofemoral junction were included. In both groups...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Joana Ferreira Adhemar Longatto-Filho Julieta Afonso Susana Roque Alexandre Lima Carneiro Isabel Vila Cristina Silva Cristina Cunha Am ílcar Mesquita Jorge Cotter Margarida Correia-Neves Armando Mansilha Pedro Cunha Source Type: research
Simplified Criteria for Identification of Familial Hypercholesterolemia in Children: Application in Real Life
CONCLUSIONS: In the pediatric population, the combination of LDL-C ≥95th percentile in the proband and the dominant inheritance pattern of hypercholesterolemia, with LDL-C ≥95th percentile in one parent, is a simple, useful and effective diagnostic criterion, showing high MDR. This pattern is crucial for early FH diagnosis. EAS, SBR and LIPIGEN-FH-PED criteria can underestimate the real number of patients with gene mutations and cannot be considered strictly discriminant for the execution of molecular analysis.PMID:38667741 | DOI:10.3390/jcdd11040123 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Raffaele Buganza Giulia Massini Maria Donata Di Taranto Giovanna Cardiero Luisa de Sanctis Ornella Guardamagna Source Type: research
Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies
J Cardiovasc Dev Dis. 2024 Apr 21;11(4):126. doi: 10.3390/jcdd11040126.ABSTRACTPatients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment. This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining future cardiovascular events. Beyond low-density lipoprotein cholesterol (LDL-c), other lipoprotein particles have not demonstrated similar contribution to the progression of atherosclerosis. Statins, ezetimibe, and more recently, proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors and bempedoic ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Muntaser Omari Mohammad Alkhalil Source Type: research
Long-Term Adherence to the Mediterranean Diet Reduces 20-Year Diabetes Incidence: The ATTICA Cohort Study (2002-2022)
This study aimed to evaluate the association between adherence to the Mediterranean diet and the 20-year incidence of type II diabetes mellitus (T2DM) among adults from the ATTICA study. This study involved a prospective cohort of 3042 men and women recruited at baseline from the Attica region in Greece. Sociodemographic, anthropometric, lifestyle, and clinical characteristics were evaluated at baseline and follow-up examinations; adherence to the Mediterranean diet was assessed through the MedDietScore (range 0-55); four Mediterranean diet trajectories were identified (i.e., increasing, decreasing, and sustained high and ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Ioanna Kechagia Thomas Tsiampalis Evangelia Damigou Fotios Barkas Georgia Anastasiou Evrydiki Kravvariti Evangelos Liberopoulos Petros P Sfikakis Christina Chrysohoou Costas Tsioufis Christos Pitsavos Demosthenes Panagiotakos Source Type: research
Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism
This article discusses the molecular biology of lactylation modifications and outlines the roles and mechanisms of lactylation modifications in cardiometabolic disorders, offering valuable insights for the diagnosis and treatment of such conditions.PMID:38668345 | DOI:10.3390/metabo14040217 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Xu Li Pingdong Cai Xinyuan Tang Yingzi Wu Yue Zhang Xianglu Rong Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
