Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study
This study is designed to explore the role of VSS in development of atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - January 19, 2021 Category: Cardiology Authors: Zhongzhao Teng, Shuo Wang, Aziz Tokgoz, Valentina Taviani, Joseph Bird, Umar Sadat, Yuan Huang, Andrew J. Patterson, Nichola Figg, Martin J. Graves, Jonathan H. Gillard Source Type: research

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study
Platelet count (PLT) is a predictor of metabolic and inflammation-related disorders. Platelets can release prochemerin, which acts as a link between coagulation and inflammation and between innate and adaptive immunity. The causal effect between PLT and circulating chemerin level has not been elucidated. Methods: Nondiabetic participants with samples in the Taiwan Biobank were recruited for genome-wide association study (GWAS) based on PLT (17,037 participants) and chemerin level (3887 participants). (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2021 Category: Cardiology Authors: Lung-An Hsu, Hsin-Hua Chou, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko Source Type: research

Residual inflammatory risk at 12 months after acute coronary syndromes is frequent and associated with combined adverse events
Residual inflammatory risk (RIR) after acute coronary syndromes (ACS) may identify patients likely to benefit from anti-inflammatory therapies. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2021 Category: Cardiology Authors: Roland Klingenberg, Soheila Aghlmandi, Baris Gencer, David Nanchen, Lorenz R äber, David Carballo, Sebastian Carballo, Barbara E. Stähli, Ulf Landmesser, Nicolas Rodondi, François Mach, Stephan Windecker, Heiner C. Bucher, Arnold von Eckardstein, Thoma Source Type: research

Increase in arterial stiffness measures after bariatric surgery
This study aimed to examine post-bariatric surgery changes in arterial stiffness and identify factors associated with greater changes in arterial stiffness. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2021 Category: Cardiology Authors: Frances M. Wang, Chao Yang, Hirofumi Tanaka, Josef Coresh, Chiadi E. Ndumele, Kunihiro Matsushita Source Type: research

Maternally inherited hypercholesterolemia does not modify the cardiovascular phenotype in familial hypercholesterolemia
The objective of this study was to analyze potential differences in anthropometry, superficial lipid deposits, comorbidities, and lipid concentrations depending on the parental origin of hypercholesterolemia within a large group of HeFH. (Source: Atherosclerosis)
Source: Atherosclerosis - January 18, 2021 Category: Cardiology Authors: Victoria Marco-Bened í, Martín Laclaustra, Ana M. Bea, Manuel Suarez-Tembra, Núria Plana, Xavier Pinto, Angel Brea, Rosa Sanchez-Hernandez, Fernando Civeira Source Type: research

Impact of bone marrow ATP-binding cassette transporter A1 deficiency on atherogenesis is independent of the presence of the low-density lipoprotein receptor
In this study, we aim to determine the contribution of Ldlr to the atheroprotective effect of hematopoietic Abca1 in the murine bone marrow transplantation model. (Source: Atherosclerosis)
Source: Atherosclerosis - January 13, 2021 Category: Cardiology Authors: Amber B. Ouweneel, Ying Zhao, Laura Calpe-Berdiel, Bart Lammers, Menno Hoekstra, Theo J.C. Van Berkel, Miranda Van Eck Source Type: research

Comparison of the mutation spectrum and association with pre and post treatment lipid measures of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries
Familial hypercholesterolaemia (FH) is commonly caused by mutation in the LDLR, APOB or PCSK9 genes, with untreated mean low density lipoprotein-cholesterol (LDL-C) concentrations being elevated in APOB mutation carriers, even higher in LDLR mutation and highest in those with a PCSK9 mutation. Here we examine this in children with FH from Norway, UK, The Netherlands, Belgium, Czech Republic, Austria, Portugal and Greece. (Source: Atherosclerosis)
Source: Atherosclerosis - January 12, 2021 Category: Cardiology Authors: Marta Futema, Uma Ramaswami, Lukas Tichy, Martin P. Bogsrud, Kirsten B. Holven, Jeanine Roeters van Lennep, Albert Wiegman, Olivier S. Descamps, Anne De Leener, Elodie Fastre, Michal Vrablik, Tomas Freiberger, Harald Esterbauer, Hans Dieplinger, Susanne G Source Type: research

Molecular imaging for risk prediction of coronary artery disease: A close or far fetched option?
Molecular imaging for atherosclerosis has been the focus of mounting interest and research over the past several years, but it has not yet reached its full potential. In the current issue of the journal, Majeed et al.1 report an interesting correlation between molecular and anatomical imaging data. In 62 patients admitted to the hospital with a diagnosis of acute coronary syndrome (ACS), the investigators performed multivessel optical coherence tomography (OCT) imaging at the time of invasive coronary angiography to acquire intravascular details of plaque instability. (Source: Atherosclerosis)
Source: Atherosclerosis - January 12, 2021 Category: Cardiology Authors: Paolo Raggi, Jonathan Abele Tags: Editorial Source Type: research

Pro-inflammatory molecules induce cholesterol accumulation in macrophages: Role of inflammatory response in foam cell formation
A recent review article by Boucher et al. "Atherosclerosis: Gone with the Wnt?" [1] discusses the role of Wnt signaling pathways in cholesterol metabolism and foam cell formation. Wnt5a is able to interfere with de novo cholesterol synthesis and promotes the efflux of cholesterol from cells by stimulating the expression of ABCA1 and ABCG1. (Source: Atherosclerosis)
Source: Atherosclerosis - January 12, 2021 Category: Cardiology Authors: Alexander N. Orekhov, Alexander M. Markin, Vasily N. Sukhorukov, Victoria A. Khotina, Ekaterina Ivanova Tags: Correspondence Source Type: research

Lipid-lowering therapies: Better together
Exposure to low-density lipoprotein cholesterol (LDL-C) causes atherosclerotic cardiovascular disease (ASCVD)1, and the importance of the mantra “lower is better for longer”2,3 cannot be understated. However, “lower” (specifically guideline-directed treatment targets), can be hard to achieve in clinical practice owing to possible adverse effects, poor compliance and adherence, and the ceiling effects of individual pharmaceutical agen ts at maximally tolerated doses4. If we additionally add the rules of “the earlier the better” and the “the longer the better”, achieving effect...
Source: Atherosclerosis - January 12, 2021 Category: Cardiology Authors: Maciej Banach, Peter.E. Penson Tags: Editorial Source Type: research

LDL-cholesterol lowering and clinical outcomes in hypercholesterolemic subjects with and without a familial hypercholesterolemia phenotype: Analysis from the secondary prevention 4S trial
Trial evidence for the benefits of cholesterol-lowering is limited for familial hypercholesterolemia (FH) patients, since they have not been the focus of large outcome trials. We assess statin use in coronary artery disease (CAD) subjects with LDL-C ≥4.9mmol/L with or without an FH-phenotype. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Antonio J. Vallejo-Vaz, Chris J. Packard, Brian A. Ference, Raul D. Santos, John J.P. Kastelein, Evan A. Stein, Alberico L. Catapano, Terje R. Pedersen, Gerald F. Watts, Kausik K. Ray Source Type: research

Antihypertensive medication adherence and cardiovascular disease risk: A longitudinal cohort study
This study aims to assess the association between antihypertensive adherence and CVD using marginal structural Cox model (MSM-Cox) and to characterize blood pressure (BP) trajectories of patients with different adherence. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Jiqing Li, Zhentang Zhang, Shucheng Si, Bojie Wang, Fuzhong Xue Source Type: research

Impedance plethysmography-based method in the assessment of subclinical atherosclerosis
The aim of this study was to examine an association of individual and combined pulse waveform parameters derived from bioimpedance measurements, that is pulse waves from a distal impedance plethysmographic (IPG), a whole-body impedance cardiographic (ICG) and transformed distal impedance plethysmographic (tIPG) signals, with markers of subclinical atherosclerosis, i.e. carotid intima-media thickness (cIMT), brachial artery flow-mediated dilation (FMD) and carotid artery distensibility (Cdist). The level of the association was also compared for arterial pulse wave velocity (PWV) and cIMT, FMD, and Cdist. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Mira Haapala, Leo-Pekka Lyytik äinen, Mikko Peltokangas, Teemu Koivistoinen, Nina Hutri-Kähönen, Mika-Matti Laurila, Matti Mäntysalo, Olli T. Raitakari, Mika Kähönen, Terho Lehtimäki, Antti Vehkaoja, Niku Oksala Source Type: research

Absence of coronary angioscopy-derived in-stent thrombi is associated with major bleeding events in acute myocardial infarction
The optimal duration of dual antiplatelet therapy for acute myocardial infarction is controversial because the bleeding risk outweighs the thromboembolic risk. We hypothesized that an in-stent thrombus (IS-thrombus) detected by coronary angioscopy (CAS) after stent implantation would be associated with high bleeding risk. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Akihito Ohgaku, Daisuke Fukamachi, Kurara Takahashi, Ran Tamiya, Shohei Migita, Saki Mizobuchi, Masatsugu Miyagawa, Yutaka Koyama, Hidesato Fujito, Riku Arai, Yasunari Ebuchi, Suguru Migita, Tomoyuki Morikawa, Masaki Monden, Norio Takei, Takehiro Tamaki, Source Type: research

Human apolipoprotein C1 transgenesis reduces atherogenesis in hypercholesterolemic rabbits
This study aimed at determining the net effect of human apoC1 on atherosclerosis in rabbits, a species with naturally high CETP activity but with endogenous apoC1 without CETP inhibitory potential. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Thomas Gautier, Val érie Deckert, Virginie Aires, Naig Le Guern, Lil Proukhnitzky, Danish Patoli, Stéphanie Lemaire, Guillaume Maquart, Amandine Bataille, Marion Xolin, Charlène Magnani, David Masson, Erwana Harscoët, Bruno Da Silva, Louis-Marie Houde Source Type: research

Acute ischemic stroke versus transient ischemic attack: Differential plaque morphological features in symptomatic intracranial atherosclerotic lesions
Intracranial atherosclerotic disease (ICAD) is a major etiologic cause for acute ischemic stroke (AIS) and transient ischemic attack (TIA). The study was designed to investigate if differential morphological features exist in symptomatic atherosclerotic lesions between AIS and TIA patients. (Source: Atherosclerosis)
Source: Atherosclerosis - January 11, 2021 Category: Cardiology Authors: Jiayu Xiao, Matthew M. Patrick, Tao Jiang, Shuang Xia, Fang Wu, Yu Guo, Nestor R. Gonzalez, Shujuan Li, Konrad H. Schlick, Oana M. Dumitrascu, Marcel M. Maya, Marcio A. Diniz, Shlee S. Song, Patrick D. Lyden, Debiao Li, Qi Yang, Zhaoyang Fan Source Type: research

Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - January 1, 2021 Category: Cardiology Source Type: research

Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: A randomized clinical trial
This study evaluated LDL-C lowering with the combination of bempedoic acid, ezetimibe, and atorvastatin. (Source: Atherosclerosis)
Source: Atherosclerosis - December 30, 2020 Category: Cardiology Authors: John Rubino, Diane E. MacDougall, Lulu R. Sterling, Jeffrey C. Hanselman, Stephen J. Nicholls Source Type: research

Spatial relationships among hemodynamic, anatomic, and biochemical plaque characteristics in patients with coronary artery disease
We aimed at characterizing the spatial proximity of plaque destabilizing features local endothelial shear stress (ESS), minimal luminal area (MLA), plaque burden (PB), and near-infrared spectroscopy (NIRS) lipid signal in high-vs. low-risk plaques. (Source: Atherosclerosis)
Source: Atherosclerosis - December 28, 2020 Category: Cardiology Authors: Anubodh S. Varshney, Ahmet U. Coskun, Gerasimos Siasos, Charles C. Maynard, Zhongyue Pu, Kevin J. Croce, Nicholas V. Cefalo, Michelle A. Cormier, Dimitris Fotiadis, Kostas Stefanou, Michail I. Papafaklis, Lampros Michalis, Stacie VanOosterhout, Abbey Muld Source Type: research

Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - December 25, 2020 Category: Cardiology Source Type: research

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events
Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke.Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of rupt...
Source: Atherosclerosis - December 22, 2020 Category: Cardiology Authors: Dani ëlle M. Coenen, Alexandra C.A. Heinzmann, Mieke F.A. Karel, Judith M.E.M. Cosemans, Rory R. Koenen Tags: Review article Source Type: research

New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention?
Elevated low-density lipoprotein cholesterol (LDL-C) is a principally modifiable cause of atherosclerotic cardiovascular disease; accordingly, recent European and US multisociety dyslipidaemia guidelines emphasise the importance of lowering LDL-C to reduce cardiovascular risk. This review provides perspectives on established and emerging agents that reduce LDL-C to help providers synthesize the abundance of new evidence related to prevention of cardiovascular disease. We provide hypothetical cases of patients with different cardiovascular risk factors and medical histories to illustrate application of current lipid-lowerin...
Source: Atherosclerosis - December 21, 2020 Category: Cardiology Authors: Dan Atar, J. Wouter Jukema, Bart Molemans, Pam R. Taub, Shinya Goto, Fran çois Mach, Cesar CerezoOlmos, James Underberg, Anthony Keech, Lale Tokgözoğlu, Marc P. Bonaca Tags: Review article Source Type: research

“Plaque erosion” or the danger of eerily quiet appearance
The characteristic histopathological features of “plaque erosion” have been extensively unveiled ever since its first description more than 20 years ago (1). Since then, the interest of both fundamental and clinical scientists working in atherosclerosis has kept rising, as reflected by the ever-growing number of articles published in this fiel d. Yet, the effective impact of this entity, as well as its underlying mechanisms, has remained largely elusive due to the lack of specific imaging modalities and diagnostic tests, and the lack of appropriate experimental models. (Source: Atherosclerosis)
Source: Atherosclerosis - December 21, 2020 Category: Cardiology Authors: Giuseppina Caligiuri, Ziad Mallat Tags: Editorial Source Type: research

2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia
A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial hypercholesterolemia (FH) already use high-intensity lipid-lowering medication at the time of an incident AMI due to their diagnosis. Hence, we hypothesized that compared with matched non-FH controls, individuals with genetically verified FH have increased mortality and risk of recurrent AMI after their first event. (Source: Atherosclerosis)
Source: Atherosclerosis - December 21, 2020 Category: Cardiology Authors: Karianne Svendsen, Henriette W. Krogh, Jannicke Igland, Grethe S. Tell, Liv J. Mundal, Kirsten B. Holven, Martin P. Bogsrud, Trond P. Leren, Kjetil Retterst øl Source Type: research

Lifestyle intervention using mobile technology and smart devices in patients with high cardiovascular risk: A pragmatic randomised clinical trial
The objective of the present trial is to evaluate the effectiveness of lifestyle intervention on the change in the atherosclerotic cardiovascular disease (ASCVD) risk score in a 1-year follow-up using smart phone technology in patients with high cardiovascular risk. (Source: Atherosclerosis)
Source: Atherosclerosis - December 20, 2020 Category: Cardiology Authors: Ahmet İlker Tekkeşin, Mert İlker Hayıroğlu, Göksel Çinier, Yelda Soluk Özdemir, Duygu İnan, Gizem Yüksel, Levent Pay, Kemal Emrecan Parsova, Elif Gökçen Vatanoğlu, Mehmet Şeker, Furkan Durak, Kadir Gürkan Source Type: research

Vascular imaging of atherosclerosis: Strengths and weaknesses
Atherosclerosis is an inflammatory disease that can lead to several complications such as ischemic heart disease, stroke, and peripheral vascular disease. Therefore, researchers and clinicians rely heavily on the use of imaging modalities to identify, and more recently, quantify the burden of atherosclerosis in the aorta, carotid arteries, coronary arteries, and peripheral vasculature. These imaging techniques vary in invasiveness, cost, resolution, radiation exposure, and presence of artifacts. (Source: Atherosclerosis)
Source: Atherosclerosis - December 20, 2020 Category: Cardiology Authors: Laura E. Mantella, Kiera Liblik, Amer M. Johri Tags: Review article Source Type: research

Fasting plasma glucose and subsequent cardiovascular disease among young adults: Analysis of a nationwide epidemiological database
Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. (Source: Atherosclerosis)
Source: Atherosclerosis - December 20, 2020 Category: Cardiology Authors: Hidehiro Kaneko, Hidetaka Itoh, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Kojiro Morita, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Hideo Yasunaga, Issei Komuro Source Type: research

Inhibition of extracellular matrix integrity attenuates the early phase of aortic medial calcification in a rodent model
In this study, we examined how the vascular ECM, especially collagen metabolism, is involved in the process of VC. (Source: Atherosclerosis)
Source: Atherosclerosis - December 20, 2020 Category: Cardiology Authors: Kenta Uto, Saeko Yoshizawa, Chiharu Aoki, Toshio Nishikawa, Hideaki Oda Source Type: research

The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank
This study investigates the cross-sectional and longitudinal relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort. (Source: Atherosclerosis)
Source: Atherosclerosis - December 20, 2020 Category: Cardiology Authors: Bradley Tucker, Sonia Sawant, Hannah McDonald, Kerry-Anne Rye, Sanjay Patel, Kwok Leung Ong, Blake J. Cochran Source Type: research

Familial hypercholesterolemia and cardiovascular disease in older individuals
Familial hypercholesterolemia (FH) is characterized by high LDL-cholesterol (LDL-C) and early atherosclerotic cardiovascular disease (ASCVD). With a lipid lowering therapy (LLT), most individuals with FH may have a longer ASCVD-free survival. However, there is scant data about older individuals with FH. (Source: Atherosclerosis)
Source: Atherosclerosis - December 18, 2020 Category: Cardiology Authors: Elaine R. Coutinho, Marcio H. Miname, Viviane Z. Rocha, Marcio S. Bittencourt, Cinthia E. Jannes, Mauricio T. Tada, Isabella R. Lima, Wilson Salgado Filho, Ana P. Chacra, Alexandre C. Pereira, Jose E. Krieger, Raul D. Santos Source Type: research

Evolution of coronary artery calcium and absolute myocardial perfusion after percutaneous revascularization
This study explored the association between progression of CAC score and changes in absolute myocardial perfusion. (Source: Atherosclerosis)
Source: Atherosclerosis - December 18, 2020 Category: Cardiology Authors: R.W. de Winter, S.P. Schumacher, W.J. Stuijfzand, P.A. van Diemen, H. Everaars, M.J. Bom, A.C. van Rossum, P.M. van de Ven, Y. Appelman, J.S. Lemkes, N.J. Verouden, A. Nap, P.G. Raijmakers, P. Knaapen Source Type: research

Calcified nodule: A rare but important cause of acute coronary syndrome with worse clinical outcomes
Calcified nodule (CN) has been reported as the least frequent cause of acute coronary syndrome (ACS), including sudden coronary death1. CN is defined as a lesion with fibrous cap disruption that is associated with eruptive, dense, calcific nodules with the presence of luminal thrombus1. Due to the low prevalence of CN, detailed studies about the etiology, as well as clinical outcomes, are limited. (Source: Atherosclerosis)
Source: Atherosclerosis - December 14, 2020 Category: Cardiology Authors: Yu Sato, Aloke V. Finn, Renu Virmani Tags: Editorial Source Type: research

Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome
18F-Sodium Fluoride Positron Emission Tomography (18F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary 18F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification. (Source: Atherosclerosis)
Source: Atherosclerosis - December 14, 2020 Category: Cardiology Authors: Kamran Majeed, Jamie W. Bellinge, Steele C. Butcher, Richard Alcock, Jon Spiro, David Playford, Graham S. Hillis, David E. Newby, Trevor A. Mori, Roslyn Francis, Carl J. Schultz Source Type: research

Soluble CD40 ligand expression in stable atherosclerosis: A systematic review and meta-analysis
The role of inflammation in atherosclerosis development and expression in different arterial territories is unclear. Soluble CD40 ligand (sCD40L) mediates inflammation and atherogenesis. Through a systematic review and meta-analysis, we assessed whether sCD40L was dysregulated in stable atherosclerosis, irrespective of the diseased arterial territory, and whether this dysregulation differed according to the specific territory. (Source: Atherosclerosis)
Source: Atherosclerosis - December 14, 2020 Category: Cardiology Authors: Tiago Pereira-da-Silva, Vera Ferreira, Alexandra Castelo, Daniel Caldeira, Patr ícia Napoleão, Teresa Pinheiro, Rui Cruz Ferreira, Miguel Mota Carmo Source Type: research

Coronary provocative tests in the catheterization laboratory: Pathophysiological bases, methodological considerations and clinical implications
The paradigm for the management of patients presenting with angina and/or myocardial ischemia has been historically centered on the detection and treatment of obstructive coronary artery disease (CAD). However, in a considerable proportion (30-50%) of patients undergoing coronary angiography, obstructive CAD is excluded. Thus, functional mechanisms may be involved in determining myocardial ischemia and should be investigated. In particular, coronary vasomotor disorders both at epicardial and at microvascular level may play a crucial role, but a definitive diagnosis of these disorders can at times be difficult, given the tr...
Source: Atherosclerosis - December 12, 2020 Category: Cardiology Authors: Rocco.A. Montone, Maria.Chiara Meucci, Antonio De Vita, Gaetano.A. Lanza, Giampaolo Niccoli Tags: Review article Source Type: research

Predicting 1-, 3- and 5-year outcomes in patients with coronary artery disease: A comparison of available risk assessment scores
Thromboischemic and bleeding events are rare but life-threatening complications after percutaneous coronary intervention (PCI). Various risk assessment models have been established to predict short- and long-term adverse events in patients with chronic and acute coronary syndromes (CCS, ACS). The aim of the present study was to compare available risk assessment systems based on their performance in identifying high-risk patients with symptomatic coronary artery disease (CAD). (Source: Atherosclerosis)
Source: Atherosclerosis - December 12, 2020 Category: Cardiology Authors: Monika Zdanyte, Robin W. Wrazidlo, Sarah Kaltenbach, Patrick Groga-Bada, Meinrad Gawaz, Tobias Geisler, Dominik Rath Source Type: research

Machine learning to predict cardiac events in asymptomatic individuals
Identifying which patients are at risk of cardiac events is an important goal and enables the application of interventions to prevent future cardiovascular events. Current cardiovascular risk scores incorporate clinical features and biochemical measures to stratify patients into risk groups.1,2 However, they have a number of limitations, including differences when applied to populations in different countries,3 overestimation of risk in contemporary multi-ethnic cohorts4 and underestimation of risk in women. (Source: Atherosclerosis)
Source: Atherosclerosis - December 11, 2020 Category: Cardiology Authors: Michelle C. Williams, David E. Newby Tags: Editorial Source Type: research

Exploring the causal pathway from bilirubin to CVD and diabetes in the UK Biobank Cohort Study: Observational findings and Mendelian randomization studies
This study aims to examine the causal effects of bilirubin on CVD, diabetes and their subtypes. (Source: Atherosclerosis)
Source: Atherosclerosis - December 7, 2020 Category: Cardiology Authors: Lei Hou, Hongkai Li, Shucheng Si, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Ran Yan, Yifan Yu, Chuan Wang, Fan Yang, Qing Wang, Fuzhong Xue Source Type: research

EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome. (Source: Atherosclerosis)
Source: Atherosclerosis - December 7, 2020 Category: Cardiology Authors: Jisun So, Dayong Wu, Alice H. Lichtenstein, Albert K. Tai, Nirupa R. Matthan, Krishna Rao Maddipati, Stefania Lamon-Fava Source Type: research

Distribution of calcium volume, density, number, and type of coronary vessel with calcified plaque in South Asians in the US and other race/ethnic groups: The MASALA and MESA studies
South Asians (SA) experience disproportionately higher rates of atherosclerotic cardiovascular disease (ASCVD) events than non-Hispanic whites and several other Asian groups. The coronary artery calcium (CAC) Agatston score may not capture the unique characteristics of coronary plaque in SA. We therefore evaluated the prevalence and patterns of advanced CAC measures (specific coronary vessel involvement, CAC volume and density) in SA versus other race/ethnicities. (Source: Atherosclerosis)
Source: Atherosclerosis - December 6, 2020 Category: Cardiology Authors: Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Miguel Cainzos-Achirica, Jaideep Patel, Matthew Budoff, Michael H. Criqui, Michael J. Blaha, Salim S. Virani Source Type: research

Dose-response relationship between blood pressure and intracranial atherosclerotic stenosis
We aimed to explore the association between blood pressure, intracranial atherosclerotic stenosis (ICAS) risks and ICAS burden in the Chinese population. (Source: Atherosclerosis)
Source: Atherosclerosis - December 5, 2020 Category: Cardiology Authors: Hong-Qi Li, Xun Wang, Hui-Fu Wang, Wei Zhang, Jing-Hui Song, Song Chi, Yan-Ping Sun, Xiao-Ling Zhong, Teng Ma, Guo-Zheng Dai, Lan Tan, Qiang Dong, Jin-Tai Yu Source Type: research

Should we treat high LDL cholesterol in ‘healthy’ elderly individuals?
Europe is an increasingly elderly society. In 2019, 14% of individuals in the European Union member countries were aged 65-79 years and about 6% were aged 80 years or more; over the next 20 years, the proportion aged at least 80 years is anticipated to more than double1. This is highly relevant in the context of prevention strategies aimed at reducing the burden of atherosclerotic cardiovascular disease (ASCVD). (Source: Atherosclerosis)
Source: Atherosclerosis - December 3, 2020 Category: Cardiology Authors: Jane Stock Source Type: research

Coronary computed tomography angiography in asymptomatic patients: Still a taboo or precision medicine?
In this issue of the journal, P érez de Isla and colleagues (1) report on 259 asymptomatic patients with genetically diagnosed familial hypercholesterolemia (FH) submitted to coronary computed tomography angiography (CCTA). They performed a quantitative assessment of coronary plaque burden and composition in all patients and foll owed them for an average of 3.9 years after the initial scan. The results should be considered in the context of the current cardiovascular risk assessment approaches. Despite advances in the diagnostic work-up and both pharmacologic and invasive treatment of coronary artery disease (CAD), ...
Source: Atherosclerosis - December 3, 2020 Category: Cardiology Authors: Grigorios Korosoglou, Yiannis Chatzizisis, Paolo Raggi Tags: Editorial Source Type: research

Chromatin modifications by the methyltransferase SETD7 modulate angiogenic response in diabetes: Insights for epigenetic-based therapies
Background and Aims: Background: Modulation of vessel growth holds great promise for the treatment of peripheral artery disease (PAD) in patients with type 2 diabetes (T2D). However, the prognosis of T2D patients with PAD remains poor as breakthrough therapies remain to be developed. Epigenetic modifications, namely DNA methylation and histone posttranslational modifications, are emerging as key players in cardiovascular disease. Aim: To investigate whether epigenetic changes modulate post-ischemic vascularization in experimental diabetes. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: S.A. Mohammed, S. Costantino, A. Akhmedov, G. Karsay, S. Ambrosini, P. Madeddu, G. Spinetti, T.F. L üscher, F. Paneni Source Type: research

Deletion of hepatic NCOR1 confers atheroprotection
Background and Aims: The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression under physiological and pathological conditions by connecting chromatin-modifying enzymes, coregulators and transcription factors. Recently we demonstrated that the deletion of macrophage NCOR1 aggravates the disease development by promoting CD36-triggered foam cell formation via PPAR γ derepression. Since NCOR1 acts as a central regulator of hepatic lipid homeostasis, we speculated that its deletion in the liver will also affect atherosclerosis development. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: S. Oppi, S. Nusser-Stein, T.F. L üscher, M.H. Oosterveer, S. Stein Source Type: research

Switching macrophage gene expression from inflammation-resolution to hemorrhage-resolution by redirection of activating transcription factor 1 (ATF1) binding by SMARCA4, BACH1 and histone H3K9 acetylation
Background and Aims: Atherosclerosis is inflammatory. The resolution of inflammation is an emerging area. Genome wide association studies (GWAS) have revealed a that vascular risk loci include SMARCA4, a SWI/SNF chromatin remodelling gene important for gene activation. We tested whether SMARCA4 is has a patho-mechanism relevant to atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: Y. Ge, L. Cave, A. Seneviratne, D. Carling, J.C. Mason, D. Haskard, J.J. Boyle Source Type: research

M2 macrophage exosomes regulate hematopoiesis & resolve inflammation in atherosclerosis via microrna cargo
Background and Aims: Macrophages produce exosomes that can travel in the circulation and be detected in atherosclerotic lesions. But whether they impact lesion dynamics is currently unknown. We investigated the therapeutic value of exosomes produced by M2-like macrophages in controlling inflammation and atherosclerosis in mice. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: L. Bouchareychas, P. Duong, S. Covarrubias, E. Alsop, T.A. Q Phu, A. Chung, M. Gomes, D. Wong, B. Meechoovet, A. Capili, R. Yamamoto, H. Nakauchi, M. Mcmanus, S. Carpenter, K. Van Keuren-Jensen, R.L. Raffai Source Type: research

Endothelial miRNAs reduce leukocyte adhesion by modulating inflammatory signal transduction pathways
Background and Aims: Inflammatory processes are essential mediators of cardiovascular disease and its attenuation or modulation may reduce the burden of atherosclerosis, myocardial infarction and heart failure. A better understanding of the mechanisms controlling the recruitment of leukocytes to the lesion, a limiting step of inflammation, is paramount for the development of better therapies. Aim: Identify endothelial miRNAs that modulated recruitment of leukocytes to inflammatory regions to gain a better understanding of cell adhesion modulatory mechanisms. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: A. Kratzer, H. Giral, M. Moobed, U. Landmesser Source Type: research

The coatomer (COP I) complex limits the cell-surface abundance of the ldl receptor and cellular LDL uptake
Background and Aims: LDLR is the main regulator of LDL-c levels in plasma. For up to 40% of patients with familial hypercholesterolemia, the genetic origin is unknown. We here aimed at the discovery and validation of novel genes limiting the uptake of LDL into hepatocytes. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: G. Panteloglou, P. Zanoni, L. Rohrer, J.A. Kuivenhoven, A. Rimbert, A. Tybjaerg-Hansen, N. Dalila, W. M ärz, A. Von Eckardstein Source Type: research

LRP1 derived peptides as a therapeutic strategy in atherosclerosis. Biochemical, in vitro and in vivo studies
The objective of this work was to study the effect of DP3 peptide on the formation of foam cells and atherosclerosis in an in vitro and in vivo model, respectively. (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: A. Benitez Amaro, C. Pallara, R. Prades, J.L. Sanchez-Quesada, D. Vilades Medel, R. Leta Petracca, F. Carreras Costa, T. Tarrago, J.C. Escol à-Gil, V. Llorente Cortes Source Type: research