Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1
A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis. Here we have explored the regulatory framework of this region to identify its functional relationship to CAD. (Source: Atherosclerosis)
Source: Atherosclerosis - February 22, 2019 Category: Cardiology Authors: S ébastien Soubeyrand, Majid Nikpay, Adam Turner, Ann-Thu Dang, Mikayla Herfkens, Paulina Lau, Ruth McPherson Source Type: research

Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via nAChRs/ROS/NF- κB signaling pathway
Cigarette smoking is an established risk factor of atherosclerosis. Nicotine, the major constituent of cigarettes, mediates the phenotype switching of vascular smooth muscle cells (VSMCs) and contributes to atherogenesis. Recent studies show that autophagy regulates atherogenesis via several pathways. The aim of this study is to determine whether nicotine regulates autophagy and subsequently mediates the phenotypic transition of VSMCs. (Source: Atherosclerosis)
Source: Atherosclerosis - February 21, 2019 Category: Cardiology Authors: Zhiyan Wang, Bei Liu, Jumo Zhu, Di Wang, Yi Wang Source Type: research

A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis
The F11 Receptor (F11R), AKA Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is an adhesion protein constitutively expressed on the membrane surface of circulating platelets and the luminal surface of inflamed endothelial cells (EC).Platelet adhesion to an inflamed endothelium is one of the early steps of atherosclerotic plaque formation. Our previous studies, conducted with cultured EC in vitro, have demonstrated the expression of F11R/JAM-A on the luminal surface of inflamed EC, platelet adhesion to inflamed EC through F11R/JAM-A interactions, and inhibition of this interaction by the presence of F11R/JAM-A antagoni...
Source: Atherosclerosis - February 21, 2019 Category: Cardiology Authors: Anna Babinska, Cristina C. Clement, Tomasz Przygodzki, Marcin Talar, Yan Li, Marcin Braun, Joanna Wzorek, Maria Swiatkowska, Yigal H. Ehrlich, Elizabeth Kornecki, Cezary Watala, Moro O. Salifu Source Type: research

Clinical, behavioral and biomarker predictors of PCSK9 levels in HIV-infected patients na ïve of statin therapy: A cross-sectional analysis from the Swiss HIV cohort
Better characterization of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) profile is currently needed to tailor appropriate lipid-lowering strategies in HIV patients. (Source: Atherosclerosis)
Source: Atherosclerosis - February 20, 2019 Category: Cardiology Authors: Baris Gencer, Sabrina Pagano, Nicolas Vuilleumier, Nathalie Satta, C écile Delhumeau-Cartier, Christoph Meier, Sabine Bavamian, Fabrizio Montecucco, François Mach, Alexandra Calmy Source Type: research

In memoriam: Dr. Akira Yamamoto 1932 –2019
Dr. Akira Yamamoto suddenly passed away after a short illness on January 7, 2019. A notice of his untimely death reached us and came as a great shock to all of us. We would like to express our heartfelt condolences to the bereaved family. (Source: Atherosclerosis)
Source: Atherosclerosis - February 15, 2019 Category: Cardiology Authors: Yuji Matsuzawa, Shizuya Yamashita, Raul D. Santos, Peter Libby, the International Atherosclerosis Society (IAS) Source Type: research

Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study
Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown. (Source: Atherosclerosis)
Source: Atherosclerosis - February 14, 2019 Category: Cardiology Authors: Kazuhiro Fujiyoshi, Yoshiyasu Minami, Kohki Ishida, Ayami Kato, Aritomo Katsura, Yusuke Muramatsu, Toshimitsu Sato, Ryota Kakizaki, Teruyoshi Nemoto, Takuya Hashimoto, Nobuhiro Sato, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako Source Type: research

Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a liver secretory enzyme that controls plasma low-density lipoprotein cholesterol (LDL-C) levels through modulation of LDL receptor (LDLR). Inhibition of PCSK9 using monoclonal antibodies (mAbs) can efficiently lower plasma LDL-C. However, the relatively short half-life of mAbs necessitates frequent passive immunization, which is costly. These limitations can be circumvented by active immunization. Here, we evaluated the long-term antiPCSK9 antibody generation in BALB/c mice vaccinated with a nanoliposomal PCSK9-specific active vaccine. (Source: Atherosclerosis)
Source: Atherosclerosis - February 13, 2019 Category: Cardiology Authors: Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Amirhossein Sahebkar Source Type: research

Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood - RADIEL study six-year follow-up
Gestational diabetes (GDM) and maternal obesity are linked to weight gain in childhood and an increased risk of cardiovascular disease later in life. We assessed the effects of GDM and maternal obesity on arterial function and morphology in relation to body anthropometrics and composition in early childhood. (Source: Atherosclerosis)
Source: Atherosclerosis - February 12, 2019 Category: Cardiology Authors: Johnny K.M. Sundholm, Linda Litwin, Kristiina R önö, Saila B. Koivusalo, Johan G. Eriksson, Taisto Sarkola Source Type: research

Effect of lipid-lowering treatment in cardiovascular disease prevalence in familial hypercholesterolemia
The impact on heterozygous familial hypercholesterolemia (HeFH) health led by high-intensity lipid-lowering therapy (HILLT) is unknown, and the question remains if there is still an unacceptably high residual risk to justify treatment with new lipid-lowering drugs. (Source: Atherosclerosis)
Source: Atherosclerosis - February 12, 2019 Category: Cardiology Authors: Sof ía Perez-Calahorra, Martín Laclaustra, Victoria Marco-Benedí, Itziar Lamiquiz-Moneo, Juan Pedro-Botet, Núria Plana, Rosa M. Sanchez-Hernandez, Antonio J. Amor, Fátima Almagro, Francisco Fuentes, Manuel Suarez-Tembra, Fernando Civeira, Dyslipemia Source Type: research

Non-alcoholic fatty liver disease presence and severity is associated with aortic stiffness beyond abdominal obesity: The ELSA-Brasil
It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with aortic stiffness in a racial/ethnically diverse and admixed society. We addressed whether NAFLD presence and severity were associated with carotid-femoral pulse wave velocity (cf-PWV) in individuals free of cardiovascular disease. (Source: Atherosclerosis)
Source: Atherosclerosis - February 12, 2019 Category: Cardiology Authors: Paulo H. Harada, Isabela JM. Bensen õr, Luciano F. Drager, Alessandra C. Goulart, José G. Mill, Paulo A. Lotufo Source Type: research

Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users
Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users. (Source: Atherosclerosis)
Source: Atherosclerosis - February 12, 2019 Category: Cardiology Authors: Francis Ribeiro de Souza, Marcelo Rodrigues dos Santos, Rafael Armani Porello, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tha ís Pinheiro Lima, Fabiana Dias Ferreira, Tiago Franco de Oliveira, Maurício Yonamine, Liliam Takayama, Rosa Source Type: research

Molecular analysis of APOB, SAR1B, ANGPTL3, AND MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients
Primary hypobetalipoproteinemia is generally considered a heterogenic group of monogenic, inherited lipoprotein disorders characterized by low concentrations of LDL cholesterol and apolipoprotein B in plasma. Lipoprotein disorders include abetalipoproteinemia, familial hypobetalipoproteinemia, chylomicron retention disease, and familial combined hypolipidemia. Our aim was to review and analyze the results of the molecular analysis of hypolipidemic patients studied in our laboratory over the last 15 years. (Source: Atherosclerosis)
Source: Atherosclerosis - February 11, 2019 Category: Cardiology Authors: Francisco Blanco-Vaca, Jes ús M. Martin-Campos, Ángel Beteta-Vicente, Marina Canyelles, Susana Martínez, Rosa Roig, Núria Farré, Josep Julve, Mireia Tondo Source Type: research

Disintegrin and metalloprotease 22 accelerates neointima formation by activating ERK signaling
Despite the advantage of arterial expansion for life-threatening vascular pathologies, the occurrence of neointima formation remains a prominent complication, with the underlying mechanisms largely unknown. Disintegrin and metalloprotease 22 (ADAM22) belongs to the family of ADAMs that possesses various biological capacities regulating vascular physiopathology. However, little is known about ADAM22 in vascular smooth muscle cell (VSMC)-mediated neointima formation. Here, we aimed to evaluate the potential functional regulation of ADAM22 in neointima formation and to further explore the underlying mechanisms. (Source: Atherosclerosis)
Source: Atherosclerosis - February 11, 2019 Category: Cardiology Authors: Shu-Min Zhang, Le Jiang, Xin Zhao, Jian-Feng Liu, Bin Liang, Chang Liu, Nian Liu, Chang-Sheng Ma Source Type: research

Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men
Endothelial injury is well-known as a process that can lead to chronic kidney disease (CKD) and atherosclerosis. Hematopoietic activity is known to be associated inversely with CKD and positively with atherosclerosis. Since bone-derived progenitor cells (CD34-positive cells) contribute to endothelial repair (including the progression of atherosclerosis), understanding the association between CKD and carotid intima-media thickness (CIMT), in relation to circulating CD34-positive cell count, may be an efficient means of clarifying the mechanisms underlying endothelial activity. (Source: Atherosclerosis)
Source: Atherosclerosis - February 11, 2019 Category: Cardiology Authors: Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Mako Nagayoshi, Kairi Kiyoura, Shoichi Fukui, Mami Tamai, Shin-Ya Kawashiri, Hideaki Kondo, Maeda Takahiro Source Type: research

Associations between statins and coronary artery disease and stroke risks in patients with asthma –chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study
To determine the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma –chronic obstructive pulmonary disease overlap syndrome (ACOS). (Source: Atherosclerosis)
Source: Atherosclerosis - February 11, 2019 Category: Cardiology Authors: Jun-Jun Yeh, Cheng-Li Lin, Chung Y. Hsu, Zonyin Shae, Chia-Hung Kao Source Type: research

Dolichoectasia of the right internal carotid artery diagnosed incidentally by MR angiography in a 17-year-old girl.
We present a very rare case in a 17-year-old girl with multiple sclerosis of dolichoectasia of the supraclinoid segment of the internal carotid artery that was found incidentally on magnetic resonance angiography and seems to represent a congenital arterial malformation. PMID: 30728879 [PubMed] (Source: Atherosclerosis)
Source: Atherosclerosis - February 9, 2019 Category: Cardiology Authors: Uchino A, Ohira M Tags: Radiol Case Rep Source Type: research

Chylomicrons: When you can't direct the wind, adjust the sail
Relegated to a lipid specialist's realm and the need for specialized laboratory testing, the diagnosis of chylomicronemia is one that is unfamiliar to most physicians. The complex diagnostic possibilities, from rare monogenic disorders to the cumulative effects of genetic predisposition, poor lifestyle, disglycemia and obesity, coupled with the lack of diagnostic capabilities in most clinical laboratories (ultracentrifugation, high-performance liquid chromatography) have made the diagnosis of severe hypertriglyceridemia fraught with therapeutic uncertainties. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2019 Category: Cardiology Authors: Latifah Alothman, Jacques Genest Tags: Editorial Source Type: research

Chylomicrons: When you can ’t direct the wind, adjust the sail
Relegated to a lipid specialist ’s realm and the need for specialized laboratory testing, the diagnosis of chylomicronemia is one that is unfamiliar to most physicians. The complex diagnostic possibilities, from rare monogenic disorders to the cumulative effects of genetic predisposition, poor lifestyle, disglycemia and obesity, coupled with the lack of diagnostic capabilities in most clinical laboratories (ultracentrifugation, high-performance liquid chromatography) have made the diagnosis of severe hypertriglyceridemia fraught with therapeutic uncertainties. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2019 Category: Cardiology Authors: Latifah Alothman, Jacques Genest Tags: Editorial Source Type: research

Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease
Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2019 Category: Cardiology Authors: Zihou Liu, Shunjun Wang, Yongqiang Wang, Ningbo Zhou, Jie Shu, Christof Stamm, Meng Jiang, Fanyan Luo Source Type: research

Very high high-density lipoprotein cholesterol is associated with increased all-cause mortality in South Korean
Our study aimed to investigate the association between high-density lipoprotein cholesterol (HDL-C) and all-cause and cause-specific mortality in Korean adults. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2019 Category: Cardiology Authors: In-Hwan Oh, Junho K. Hur, Jae-Hong Ryoo, Ju Young Jung, Sung Keun Park, Hong Jun Yang, Joong-Myung Choi, Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh Source Type: research

Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis
Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis of the CCs, production of reactive oxygen species (ROS) and release of cytokines. The cyclodextrin 2-hydroxypropyl- β-cyclodextrin has been found to reduce CC-induced complement activation and induce regression of established atherosclerotic plaques in a mouse model of atherosclerosis, thus inhibition of complement with cyclodextrins is a potential new strategy for treatment of inflammation during atherosclerosi s. (Source: Atherosclerosis)
Source: Atherosclerosis - February 3, 2019 Category: Cardiology Authors: Katrine Pilely, Siril S. Bakke, Yaseelan Palarasah, Mikkel-Ole Skjoedt, Emil D. Bartels, Terje Espevik, Peter Garred Source Type: research

Statins for primary prevention in adults aged 75 years and older: A nationwide population-based case-control study
This study evaluated whether statins are beneficial for primary prevention of cardiovascular disease (CVD) and all-cause death in adults aged ≥ 75 years. (Source: Atherosclerosis)
Source: Atherosclerosis - February 1, 2019 Category: Cardiology Authors: Ji Eun Jun, In-Jin Cho, Kyungdo Han, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang Source Type: research

Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice
Our previous data showed that lymphatic function impairment occurs before the onset of atherosclerosis in mice and is precociously associated with a defect in the propelling capacity of the collecting lymphatic vessels. Concomitantly, we found that lymphatic transport can be restored in mice by systemic injections of a mutant form of VEGF-C (VEGF-C 152s), a growth factor known to increase mesenteric collecting lymphatic vessel pumping through a VEGFR-3-dependent mechanism in rats. In the present study, we aimed to determine whether and how early modulation of collecting lymphatic vessel function could restrain atherosclero...
Source: Atherosclerosis - January 31, 2019 Category: Cardiology Authors: Andreea Milasan, Ali Smaani, Catherine Martel Source Type: research

Decrease in oxidized high-density lipoprotein is associated with slowed progression of coronary artery calcification: Subanalysis of a prospective multicenter study
Oxidized high-density lipoprotein (oxHDL) is characterized by reduced anti-inflammatory properties compared with HDL. However, the role of oxHDL in the pathogenesis of coronary artery calcification (CAC), a marker of subclinical atherosclerosis, remains unclear. We prospectively investigated the association between the change in oxHDL and the progression of CAC in a substudy of a multicenter study. (Source: Atherosclerosis)
Source: Atherosclerosis - January 31, 2019 Category: Cardiology Authors: Takashi Miki, Toru Miyoshi, Kazuhiko Kotani, Kunihisa Kohno, Hirohiko Asonuma, Satoru Sakuragi, Yasushi Koyama, Kazufumi Nakamura, Hiroshi Ito Source Type: research

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and includes a spectrum of abnormalities ranging from steatosis to cirrhosis. In this review, we address recent evidence and limitations of studies that evaluated the association of NAFLD with atherosclerotic cardiovascular disease. NAFLD is considered an ectopic fat deposit associated with metabolic (insulin resistance, hyperglycemia and dyslipidemia), inflammatory, coagulation and blood pressure disturbances. Prospective studies have associated NAFLD presence and severity, particularly steatohepatitis and fibrosis, with an increased risk of cardiovascular dise...
Source: Atherosclerosis - January 30, 2019 Category: Cardiology Authors: Raul D. Santos, Luca Valenti, Stefano Romeo Tags: Review article Source Type: research

The Barcelona-Asymptomatic Intracranial Atherosclerosis study: Subclinical intracranial atherosclerosis as predictor of long-term vascular events
The objective of our study was to determine if subclinical intracranial atherosclerosis is associated with long-term incident vascular events in Caucasians. (Source: Atherosclerosis)
Source: Atherosclerosis - January 29, 2019 Category: Cardiology Authors: Anna Planas-Ballv é, Ane Miren Crespo, Lorena Martín Aguilar, María Hernández-Pérez, Tamara Canento, Laura Dorado, María T. Alzamora, Pere Torán, Guillem Pera, Laura Muñoz-Ortiz, Juan F. Arenillas, María Castañón, Antoni Dávalos, Mónica Mill Source Type: research

Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis
Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, however, the underlying mechanisms that link CKD and CVD are not fully understood and limited treatment options exist in this high-risk population. microRNAs (miRNA) are critical regulators of gene expression for many biological processes in atherosclerosis, including endothelial dysfunction and inflammation. We hypothesized that renal injury-induced endothelial miRNAs promote atherosclerosis. Here, we demonstrate that dual inhibition of endothelial miRNAs inhibits atherosclerosis in the setting of renal injury. (Source: Atherosclerosis)
Source: Atherosclerosis - January 29, 2019 Category: Cardiology Authors: Carrie B. Wiese, Jianyong Zhong, Zhi-Qi Xu, Youmin Zhang, Marisol Ramirez-Solano, Wanying Zhu, MacRea F. Linton, Quanhu Sheng, Valentina Kon, Kasey C. Vickers Source Type: research

Lipid-lowering response in subjects with the p.(Leu167del) mutation in the APOE gene
The aim of this work was to compared the effect of lipid lowering drugs among FH subjects with a functional mutation in LDLR (LDLR FH) and FH with the p.(Leu167del) mutation in APOE. (Source: Atherosclerosis)
Source: Atherosclerosis - January 29, 2019 Category: Cardiology Authors: Ana M. Bea, Itziar Lamiquiz-Moneo, Victoria Marco-Bened í, Rocio Mateo-Gallego, Sofía Pérez-Calahorra, Estíbaliz Jarauta, César Martín, Ana Cenarro, Fernando Civeira Source Type: research

Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice
Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in triglyceride hydrolysis, and GPIHBP1 deficiency leads to severe hypertriglyceridemia (HTG). Gpihbp1 knockout (GKO) mice develop mild lesions in the aortic root at the age of 11 months. Herein, we investigated the effect of Gpihbp1 deficiency on atherosclerosis (AS) under diabetic conditions. (Source: Atherosclerosis)
Source: Atherosclerosis - January 28, 2019 Category: Cardiology Authors: Xuejing Liu, Jingyi Li, Jiawei Liao, Huan Wang, Xiaomin Huang, Zhao Dong, Qiang Shen, Ling Zhang, Yuhui Wang, Wei Kong, George Liu, Wei Huang Source Type: research

The impact of sedentary behavior patterns on carotid atherosclerotic burden: Implications from the Corinthia epidemiological study
Sedentary lifestyle, unlike leisure time physical activity (PA), is associated with atherosclerosis progression. Regarding the interrelationship between television watching, as a sedentary behavior pattern, and cardiovascular disease burden, few data exist. (Source: Atherosclerosis)
Source: Atherosclerosis - January 28, 2019 Category: Cardiology Authors: George Lazaros, Evangelos Oikonomou, Georgia Vogiatzi, Evangelia Christoforatou, Sotirios Tsalamandris, Athina Goliopoulou, Maria Tousouli, Vasiliki Mystakidou, Christos Chasikidis, Dimitris Tousoulis Source Type: research

Glucose ‒6‒phosphate dehydrogenase deficiency and risk of cardiovascular disease: A propensity score‒matched study
Cardiovascular disease (CVD) is associated with high morbidity and mortality. Studies in animal models and humans suggested that glucose ‒6‒phosphate dehydrogenase (G6PD) deficiency, a genetically inherited condition causing haemolytic anemia, may be a risk factor for CVD. This hypothesis was tested in a large cohort from Northern Sardinia, where the population prevalence of G6PD deficiency is the highest in the Mediterranean are a. (Source: Atherosclerosis)
Source: Atherosclerosis - January 28, 2019 Category: Cardiology Authors: Giovanni Mario Pes, Guido Parodi, Maria Pina Dore Source Type: research

Protective effect of influenza vaccination on outcomes in geriatric stroke patients: A nationwide matched cohort study
The effects of influenza vaccination (IV) on stroke outcomes are unclear. The purpose of this study is to evaluate the outcomes after stroke in elderly individuals who have received an IV. (Source: Atherosclerosis)
Source: Atherosclerosis - January 26, 2019 Category: Cardiology Authors: Fai Lam, Ta-Liang Chen, Chun-Chuan Shih, Chao-Shun Lin, Chun-Chieh Yeh, Yuarn-Jang Lee, Chaur-Jong Hu, Hung-Yi Chiou, Chien-Chang Liao Source Type: research

The “cholesterol paradox” in patients with mastocytosis
Indhirajanti et al. have documented that in some patients with mastocytosis there is a higher prevalence of cardiovascular events. This basic data serves the authors to highlight how mast cells contribute to the destabilization of atherosclerotic lesion and cardiovascular events, despite the low levels of total cholesterol and LDL cholesterol [1]. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Raimondo Femin ò, Giovanni Feminò Tags: Correspondence Source Type: research

An update on statins: Pleiotropic effect performed in intracerebral hemorrhage
We read with interest the recent article by Chung et al. [1] published in this issue of Atherosclerosis, in which the authors demonstrated that patients with intracerebral hemorrhage (ICH), who continued statin therapy, had better all-cause mortality outcomes compared with those who did not continue statin therapy. Although the authors have some possible explanations for the mechanism via the pleiotropic effect of statins, such as anti-oxidative, BBB protection and anti-inflammation, experimental evidence of continue statin therapy is still lacking. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Qianwei Chen, Jianbo Zhang, Hua Feng, Zhi Chen Tags: Correspondence Source Type: research

A new variant (c.1A > G) in LDLRAP1 causing autosomal recessive hypercholesterolemia: Characterization of the defect and response to PCSK9 inhibition
Autosomal recessive hypercholesterolemia (ARH) is a rare disorder caused by mutations in LDLRAP1, which impairs internalization of hepatic LDL receptor (LDLR). ARH patients respond relatively well to statins or the combination of statins and Ezetimibe, but scarce and variable data on treatment with PCSK9 inhibitors are available. We aimed to identify and characterize the defect in a hypercholesterolemic patient with premature cardiovascular disease and determine the response to lipid-lowering treatment. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Carmen Rodr íguez-Jiménez, Diego Gómez-Coronado, Manuel Frías Vargas, Francisca Cerrato, Carlos Lahoz, Jose Saban-Ruiz, Daniel González-Nieto, Miguel A. Lasunción, José M. Mostaza, Sonia Rodríguez-Nóvoa Source Type: research

Coronary artery calcium score to guide hypertension therapy!
Hypertension is the most prevalent non-communicable disease, estimated to affect 1.13 billion individuals nowadays. It is the leading preventable cause of mortality worldwide and a major risk factor for coronary artery disease, heart failure, stroke and chronic renal diseases in developed and developing countries.1,2. Worldwide, the aging population, decreased fitness and obesity epidemic have contributed to the increased prevalence of hypertension3. Given that, it poses a significant health and economic challenge to both developed and developing countries. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Ahmed Aljizeeri, Ahmed Alsaileek, Mouaz H. Al-Mallah Tags: Editorial Source Type: research

Association between serum magnesium levels and peripheral artery disease: A leg too short?
The only way to keep your health is to eat what you don't want, drink what you don't like, and do what you'd rather notMark Twain (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Alberto Morello, Giuseppe Biondi-Zoccai, Giacomo Frati, Arturo Giordano Tags: Editorial Source Type: research

Heparanase in health and disease: The neglected housekeeper of the cell?
The membrane of most cells in the body is surrounded by a dynamically regulated, highly-hydrated fibrous meshwork of carbohydrates, known as pericellular matrix or glycocalyx. Its main constituents are several glycoconjugates (see nomenclature and definitions in Box 1), including glycolipids, the polysaccharide heparan sulfate (HS) linked to proteoglycan core proteins (e.g. glypican, syndecan, betaglycan), the polysaccharide hyaluronan and proteins bound to these polysaccharides. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Jun Shu, Gaetano Santulli Tags: Editorial Source Type: research

Coronary calcium is all we need for risk assessment, yet we do not use it often enough
In an investigation published in this issue of Atherosclerosis, Zhao et al.1 tested the hypothesis that atherosclerosis detected at multiple sites provides important prognostic information in patients with and without cardiometabolic disorders followed for an average of 10.5 years from screening. In 1,675 patients enrolled in the Multi Ethnic Study of Atherosclerosis (MESA), they performed computed tomography (CT) imaging of the coronary arteries and aorta and measured their respective calcium scores. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Paolo Raggi Tags: Editorial Source Type: research

The “cholesterol paradox” in patients with mastocytosis”
Indhirajanti et al. have documented that in some patients with mastocytosis there is a higher prevalence of cardiovascular events. This basic data serves the authors to highlight how mast cells contribute to the destabilization of atherosclerotic lesion and cardiovascular events, despite the low levels of total cholesterol and LDL cholesterol1. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Raimondo Femin ò, Giovanni Feminò Tags: Correspondence Source Type: research

An update on statins: Pleiotropic effect on intracerebral hemorrhage
We read with interest the recent article by Chung et al.1, in which the authors demonstrated that patients with intracerebral hemorrhage (ICH) who continued statin therapy had better all-cause mortality outcomes compared with those who did not continue statin therapy. Although the authors have some possible explanations for the mechanism via the pleiotropic effect of statins, such as anti-oxidative, BBB protection and anti-inflammation, experimental evidence of continue statin therapy is lacking. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Qianwei Chen, Jianbo Zhang, Hua Feng, Zhi Chen Tags: Correspondence Source Type: research

Comments on: “High ankle-brachial index and risk of cardiovascular or all-cause mortality: A meta-analysis”
We read with great interest the recent updated article by Gu et al. suggesting high Ankle-Brachial Index (ABI) is independently associated with an increased risk of all-cause mortality (1). The authors did a great work and we would like to congratulate them. However, we would like to comment on a few issues in the study that are important for clinicians dealing with this situation and expand on the pooled analysis using the same data included in the current paper. We would like to emphasize some important points about this well-written study. (Source: Atherosclerosis)
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Syed Raza Shah, Najla Issa Najim, Waqas Shahnawaz, Muhammad Ahmed Jangda Tags: Correspondence Source Type: research

Stroke occurrence while on antiplatelet therapy may predict atrial fibrillation detected after stroke
Stroke occurrence while on antiplatelet therapy, i.e., a breakthrough stroke, is often conveniently attributed to antiplatelet resistance. However, undetected paroxysmal atrial fibrillation (AF) may underlie breakthrough strokes. We hypothesized that a breakthrough stroke may be a clinical marker for patients at risk of having AF detected after stroke (AFDAS). (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2019 Category: Cardiology Authors: Cheng-Yang Hsieh, Cheng-Han Lee, Sheng-Feng Sung Source Type: research

The association of midlife cardiorespiratory fitness with later life carotid atherosclerosis: Cooper Center Longitudinal Study
While numerous cross-sectional studies have demonstrated an inverse relationship between cardiorespiratory fitness (CRF) and carotid atherosclerosis in middle age, much less is known about the association of midlife CRF with carotid atherosclerosis in later life. (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2019 Category: Cardiology Authors: Joowon Lee, Baojiang Chen, Harold W. Kohl, Carolyn E. Barlow, Chong do Lee, Nina B. Radford, Laura F. DeFina, Kelley Pettee Gabriel Source Type: research

The novel inflammatory marker GlycA and the prevalence and progression of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis
GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Whether GlycA is linked to extra-coronary calcifications (ECC) is not well established. (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2019 Category: Cardiology Authors: Angelica Ezeigwe, Oluwaseun E. Fashanu, Di Zhao, Matthew J. Budoff, James D. Otvos, Isac C. Thomas, Samia Mora, Martin Tibuakuu, Erin D. Michos Source Type: research

Utility of novel serum biomarkers to predict subclinical atherosclerosis: A sub-analysis of the EISNER study
Certain novel biomarkers may predict atherosclerotic cardiovascular disease (ASCVD) events; however, data on their relationship to coronary atherosclerosis and its progression as measured by coronary artery calcium (CAC) scanning is lacking. We evaluated the association between novel biomarkers and presence or progression of CAC. (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2019 Category: Cardiology Authors: Shuktika Nandkeolyar, Ali Naqvi, Wenjun Fan, Ajay Sharma, Jamal S. Rana, Alan Rozanski, Leslee Shaw, John D. Friedman, Sean Hayes, Damini Dey, Nathan D. Wong, Daniel S. Berman Source Type: research

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells
Obesity is associated with an increased risk of cardiovascular disease, but the mechanisms involved are not completely understood. In obesity, the adipocyte microenvironment is characterised by both hypoxia and inflammation. Therefore, we sought to determine whether extracellular vesicles (EVs) derived from adipocytes in this setting might be involved in mediating cardiovascular disease, specifically by promoting leukocyte attachment to vascular endothelial cells. (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2019 Category: Cardiology Authors: Rebecca M. Wadey, Katherine D. Connolly, Donna Mathew, Gareth Walters, D. Aled Rees, Philip E. James Source Type: research

Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis
Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2019 Category: Cardiology Authors: Konark Malhotra, Apostolos Safouris, Nitin Goyal, Adam Arthur, David S. Liebeskind, Aristeidis H. Katsanos, Jo ão Sargento-Freitas, Marc Ribo, Carlos Molina, Jong-Won Chung, Oh Young Bang, Georgios Magoufis, Ahmad Cheema, Steven J. Shook, Ken Uchino, And Source Type: research

Deciphering the role of V200A and N291S mutations leading to LPL deficiency
Type I hyperlipoproteinemia is an autosomal recessive disorder of lipoprotein metabolism caused by mutations in the LPL gene, with an estimated prevalence in the general population of 1 in a million. In this work, we studied the molecular mechanism of two known mutations in the LPL gene by ex vivo and in vitro experiments and also the effect of two splice site mutations by ex vivo experiments. (Source: Atherosclerosis)
Source: Atherosclerosis - January 20, 2019 Category: Cardiology Authors: Margherita Botta, Elisabeth Maurer, Massimiliano Ruscica, Stefano Romeo, Thomas M. Stulnig, Piero Pingitore Source Type: research

Socioeconomic and geographic variations in the prevalence, awareness, treatment and control of dyslipidemia in middle-aged and older Chinese
Unevenly socioeconomic development and nutrition transition might bring large variations in the epidemiology of dyslipidemia. We aimed to estimate the prevalence, awareness, treatment and control of dyslipidemia in different socioeconomic status and geographic regions in China, and to assess the associated factors and comorbidities of dyslipidemia. (Source: Atherosclerosis)
Source: Atherosclerosis - January 19, 2019 Category: Cardiology Authors: Peige Song, Mingming Zha, Xiangming Yang, Yuehong Xu, Hanyu Wang, Zhe Fang, Xiangrong Yang, Wei Xia, Chunxian Zeng Source Type: research