Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention
Heart Int. 2023 Nov 1;17(2):27-34. doi: 10.17925/HI.2023.17.2.1. eCollection 2023.ABSTRACTThe management of low-density lipoprotein cholesterol (LDL-C) levels is a central strategy for the prevention of atherosclerotic cardiovascular disease. Current United States (2018 American Heart Association/American College of Cardiology/Multisociety) and European (2019 European Society of Cardiology/European Atherosclerosis Society) guidelines endorse statin therapy as the first-line therapy for pharmacologic LDL-C lowering. However, in clinical practice up to 30% of patients report partial or complete intolerance to statin therapy....
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Michael Albosta Jelani K Grant Erin D Michos Source Type: research

An overview of pharmacological effects of Crocus sativous and its constituents
Iran J Basic Med Sci. 2024;27(4):391-417. doi: 10.22038/IJBMS.2023.73410.15950.ABSTRACTCrocus sativus L. was used for the treatment of a wide range of disorders in traditional medicine. Due to the extensive protective and treatment properties of C. sativus and its constituents in various diseases, the purpose of this review is to collect a summary of its effects, on experimental studies, both in vitro and in vivo. Databases such as PubMed, Science Direct, and Scopus were explored until January 2023 by employing suitable keywords. Several investigations have indicated that the therapeutic properties of C. sativus may be due...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Saeideh Saadat Zahra Ghasemi Arghavan Memarzia Sepideh Behrouz Mohammad Reza Aslani Mohammad Hossein Boskabady Source Type: research

Financial strain is associated with poorer cardiovascular health: The multi-ethnic study of atherosclerosis
CONCLUSION: Financial strain was associated with poorer CVH. More research is needed to understand this relationship so the burden of CVD can be decreased, particularly among people experiencing financial hardship.PMID:38419947 | PMC:PMC10899015 | DOI:10.1016/j.ajpc.2024.100640 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Olatokunbo Osibogun Oluseye Ogunmoroti Ruth-Alma Turkson-Ocran Victor Okunrintemi Kiarri N Kershaw Norrina B Allen Erin D Michos Source Type: research

A Case of Spontaneous Coronary Artery Dissection
Cureus. 2024 Jan 29;16(1):e53174. doi: 10.7759/cureus.53174. eCollection 2024 Jan.ABSTRACTSpontaneous coronary artery dissection (SCAD) is the development of an intramural hematoma that causes a false lumen to form, leading to occlusion and ischemia. It is a rare but separate pathologic cause of acute coronary syndrome, more commonly occurring in females and often associated with underlying vascular conditions. Definitive diagnosis requires invasive coronary angiography. Management is similar to that of myocardial infarction caused by atherosclerosis; however, the majority of SCADs are managed conservatively, as stenting o...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Connor Rougelot Micah Pippin Source Type: research

Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation
iScience. 2024 Feb 12;27(3):109204. doi: 10.1016/j.isci.2024.109204. eCollection 2024 Mar 15.ABSTRACTPathogenic mycobacteria orchestrate the complex cell populations known as granuloma that is the hallmark of tuberculosis. Foam cells, a lipid-rich cell-type, are considered critical for granuloma formation; however, the causative factor in foam cell formation remains unclear. Atherosclerosis is a chronic inflammatory disease characterized by the abundant accumulation of lipid-laden-macrophage-derived foam cells during which cholesterol 25-hydroxylase (CH25H) is crucial in foam cell formation. Here, we show that M. marinum (...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Shuang Zhou Ding Zhang Dan Li Hankun Wang Cairong Ding Jingrui Song Weifeng Huang Xuan Xia Ziwei Zhou Shanshan Han Zhu Jin Bo Yan Jacqueline Gonzales Laura E Via Lu Zhang Decheng Wang Source Type: research

Inverted U-Shaped Association of Plasma Resolvin D2 With Atherosclerotic Cardiovascular Disease and the Mediation Effects of Serum Cholesterol: A Chinese Community-Based Study
CONCLUSIONS: Both lower and higher RvD2 levels are associated with a reduced risk of ASCVD, forming an inverted U-shaped relationship. Furthermore, this association is partially mediated by total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.PMID:38420767 | DOI:10.1161/JAHA.123.032588 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Bingyue Liu Jin Zhang Kexin Zhang Mengyuan Li Yang Jing Shujun Gu Hongzhan Ding Yanyu Liang Hui Zhou Chen Dong Source Type: research

Potential Protein Signatures for Recurrence Prediction of Ischemic Stroke
CONCLUSIONS: These findings provide a foundation for developing a blood-based biomarker panel, using causative classifications, which may be used in routine clinical practice to predict stroke recurrence.PMID:38420847 | DOI:10.1161/JAHA.123.032840 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Chengyi Zhang Yang Liu Huimin Zhu Xinying Huang Cang Guo Si Cheng Meng Yuan Yong Jiang Xia Meng S Claiborne Johnston Yongjun Wang Wei-Na Jin Fu-Dong Shi Source Type: research

VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis
Nanomedicine (Lond). 2024 Feb 29. doi: 10.2217/nnm-2023-0282. Online ahead of print.ABSTRACTVascular cell adhesion molecule-1 (VCAM-1) was identified over 2 decades ago as an endothelial adhesion receptor involved in leukocyte recruitment and cell-based immune responses. In atherosclerosis, a chronic inflammatory disease of the blood vessels that is the leading cause of death in the USA, endothelial VCAM-1 is robustly expressed beginning in the early stages of the disease. The interactions of circulating immune cells with VCAM-1 on the activated endothelial cell surface promote the uptake of monocytes and the progression o...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Rita Castro James H Adair Andrea M Mastro Thomas Neuberger Gail L Matters Source Type: research

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy
CONCLUSION: On baseline imaging of this Dutch Registry, men and women with LVO mainly differ in vessel characteristics such as atherosclerotic burden, extracranial vessel tortuosity, and collateral status. These sex differences do not result in different reperfusion rates and are, therefore, not likely to explain the worse functional outcome in women after EVT.PMID:38420950 | DOI:10.1177/23969873241231125 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Anne van der Meij Ghislaine Holswilder Marie Louise E Bernsen Hendrikus Ja van Os Jeannette Hofmeijer Fianne Hm Spaander Jasper M Martens Ido R van den Wijngaard Hester F Lingsma Praneeta R Konduri Charles Blm Majoie Wouter J Schonewille Diederik Wj Dippe Source Type: research

Association between multiple sleep dimensions in obstructive sleep apnea and the early sign of atherosclerosis
CONCLUSIONS: Subjects with more severe sleep fragmentation, more severe hypoxemia and increased arousability were more likely to have increased CIMT after adjusting for potential confounders. It is important to evaluate novel indices of sleep fragmentation, hypoxemia and arousability in OSA for early detection and prevention of cardiovascular disease, including stroke.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry; URL: http://www.chictr.org.cn/showproj.aspx?proj=43057; No. ChiCTR1900025714.PMID:38420989 | DOI:10.5664/jcsm.11090 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Weijun Huang Enhui Zhou Jinngyu Zhang Tianjiao Zhou Xiaoting Wang Jinhong Shen Huaming Zhu Jian Guan Hongliang Yi Shankai Yin Source Type: research

Atherosclerotic Plaque Erosion: Mechanisms, Clinical Implications, and potential therapeutic Strategies - a review
This article provides an overview of atherosclerotic plaque erosion characteristics and its underlying mechanisms, highlights its clinical implications, and discusses potential therapeutic strategies.PMID:38421206 | DOI:10.1097/FJC.0000000000001554 (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Sharon Bruoha Mattia Galli Pierre Sabouret Chaim Yosefy Louay Taha Felice Gragnano Michael P Savage Mony Shuvy Giuseppe Biondi-Zoccai Michael Glikson Elad Asher Source Type: research

Identification of circular RNA hsa_circ_0034621 as a novel biomarker for carotid atherosclerosis and the potential function as a regulator of NLRP3 inflammasome
This study aimed to identify the NLRP3 inflammasome-associated circRNA biomarkers of carotid atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Yu-Xiang Yan, Ya-Ke Lu, Yu-Hong Liu, Jie Zhang, Shuo Wang, Jing Dong, Huan-Bo Xiao Source Type: research

The role of 27-hydroxycholesterol in meta-inflammation
Korean J Physiol Pharmacol. 2024 Mar 1;28(2):107-112. doi: 10.4196/kjpp.2024.28.2.107.ABSTRACT27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic irregularities. 27OHChol activates monocytic cells such that they secrete pro-inflammatory cytokines and chemokines, and increase the expression of cell surface molecules such as pattern-recognit...
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Yonghae Son Eunbeen Choi Yujin Hwang Koanhoi Kim Source Type: research

lncRNA GAPLINC regulates vascular endothelial cell apoptosis in atherosclerosis
CONCLUSIONS: The present study demonstrates that upregulation of lncRNA GAPLINC represses the binding of miR-183-5p to the PDCD4 promoter region and then promotes PDCD4 expression, thereby inducing cell apoptosis and suppressing endothelial cell proliferation.PMID:38414459 | PMC:PMC10895973 | DOI:10.5114/aoms/169383 (Source: Atherosclerosis)
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Jun Pan Bing Wang Xibin Pu Chenyang Qiu Donglin Li Ziheng Wu Honkun Zhang Yangyan He Source Type: research

Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels
Arch Med Sci. 2024 Jan 31;20(1):8-27. doi: 10.5114/aoms/183522. eCollection 2024.ABSTRACTLipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and a specific apolipoprotein(a). The blood concentration of Lp(a) is approximately 90% genetically determined, and the main genetic factor determining Lp(a) levels is the size of the apo(a) isoform, which is determined by the number of KIV2 domain repeats. The size of the apo(a) isoform is inversely proportional to the blood concentration of Lp(a). Lp(a) is a strong and independent cardiovascular risk factor. Elevated Lp(a) levels ≥ 50 mg/dl (≥ 125 nmol/...
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Bo żena Sosnowska Janina Stepinska Przemyslaw Mitkowski Agata Bielecka-Dabrowa Beata Bobrowska Jan Budzianowski Pawel Burchardt Krzysztof Chlebus Piotr Dobrowolski Mariusz Gasior Piotr Jankowski Jacek Kubica Agnieszka Mickiewicz Malgorzata Mysliwiec Tade Source Type: research