Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - September 23, 2021 Category: Cardiology Source Type: research

Global Familial hypercholesterolemia Studies Collaboration (FHSC) highlights the challenges of care
Familial hypercholesterolemia (FH) is a common inherited condition, affecting about one in 300 people worldwide, and is characterised by elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth [1 –3]. If untreated, this burden of lifelong high LDL-C levels predisposes to premature atherosclerotic cardiovascular disease (ASCVD), with individuals often experiencing their first myocardial infarction during middle-age [1]. However, if detected early – ideally during childhood – with prompt initiation of guideline-recommended lipid lowering therapy, individuals with this condition can live a ...
Source: Atherosclerosis - September 22, 2021 Category: Cardiology Authors: Jane Stock Source Type: research

Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies
Over the past fifteen years, treatments using monoclonal antibodies specifically targeting cytokines have been developed to treat chronic inflammatory diseases, including rheumatoid arthritis or psoriasis, both associated with increased cardiovascular risk. The cardiovascular impact of these therapies allows us to validate the clinical relevance of the knowledge acquired from experimental studies about the role of cytokines in atherosclerosis. Several clinical studies have confirmed the protective effects of anti-TNF α and anti-IL-6R monoclonal antibodies against athero-thrombotic cardiovascular risk in patients with...
Source: Atherosclerosis - September 22, 2021 Category: Cardiology Authors: Esther Lutgens, Jeremie Joffre, Bram van Os, Hafid Ait-Oufella Source Type: research

Association of plasma trimethylamine N-oxide levels with atherosclerotic cardiovascular disease and factors of the metabolic syndrome
The association of plasma trimethylamine N-oxide (TMAO) with atherosclerotic cardiovascular disease (ASCVD), diabetes mellitus (DM) and its determinants, as well as the role of TMAO as a predictor for short and long-term mortality, is still under discussion. We investigated associations between four plasma metabolites of the TMAO pathway and different clinical manifestations of atherosclerosis, diabetes determinants, and risk of short and long-term mortality in patients with stable ASCVD, acute myocardial infarction (AMI), cardiogenic shock (CS), and DM in three independent cohorts. (Source: Atherosclerosis)
Source: Atherosclerosis - September 22, 2021 Category: Cardiology Authors: Clemens Ringel, Julia Dittrich, Alexander Gaudl, Paul Schellong, Carl Friedrich Beuchel, Ronny Baber, Frank Beutner, Andrej Teren, Christoph Engel, Kerstin Wirkner, Holger Thiele, Petra B üttner, Markus Löffler, Markus Scholz, Joachim Thiery, Uta Ceglar Source Type: research

The association between markers of inflammation and retinal microvascular parameters: A systematic review and meta-analysis
Adverse changes to the microcirculation play an important role in the pathogenesis of cardiovascular disease (CVD), and inflammation is a key causal mechanism. We investigated the relationship between inflammatory markers and retinal microvascular parameters. (Source: Atherosclerosis)
Source: Atherosclerosis - September 22, 2021 Category: Cardiology Authors: Mengjiao Liu, Claire Lovern, Kate Lycett, Mingguang He, Melissa Wake, Tien Yin Wong, David P. Burgner Source Type: research

Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation
After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. (Source: Atherosclerosis)
Source: Atherosclerosis - September 21, 2021 Category: Cardiology Authors: Joanna Hlebowicz, Johan Holm, Sandra Lindstedt, Isabel Goncalves, Jan Nilsson Source Type: research

Coronary calcium in autoimmune diseases: A systematic literature review and meta-analysis
Autoimmune diseases (AID) share various clinical signs and symptoms and pathophysiological mechanisms including the increased risk of cardiovascular disease. The coronary artery calcium score (CACS) is potentially useful in improving the cardiovascular risk assessment. The aim of this study was to evaluate the CACS in six AIDs analyzed as a group compared with controls through a systematic literature review (SLR) and meta-analysis. (Source: Atherosclerosis)
Source: Atherosclerosis - September 20, 2021 Category: Cardiology Authors: Mar ía Alejandra Martínez-Ceballos, Jhoan Camilo Sinning Rey, Juan Pablo Alzate- Granados, Claudia Mendoza-Pinto, Mario García-Carrasco, Lorena Montes-Zabala, Diana Vargas-Vergara, Pamela Munguia-Realpozo, Ivet Etchegaray-Morales, Adriana Rojas-Villarr Source Type: research

The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease
We aimed to determine the relationship between statin adherence measured directly, and by self-report measures and serum cholesterol levels. (Source: Atherosclerosis)
Source: Atherosclerosis - September 18, 2021 Category: Cardiology Authors: Oscar Kristiansen, Elise Sverre, Kari Peersen, Morten Wang Fagerland, Erik Gjertsen, Lars Gullestad, Joep Perk, Toril Dammen, Einar Husebye, Nils Tore Vethe, John Munkhaugen Source Type: research

CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients
CCN family member 1 (CCN1) has recently been proposed as a novel biomarker of myocardial injury, improving prediction of 30-day and one-year mortality following acute coronary syndromes. Among ST-elevation myocardial infarction (STEMI) patients, we evaluated the utility of CCN1 measured immediately before primary percutaneous coronary intervention (PPCI) as a predictor of two earlier endpoints: final myocardial infarct size and post-infarction left ventricular ejection fraction (LVEF). Furthermore, we evaluated the impact of CCN1 on the discriminatory power of the CADILLAC score. (Source: Atherosclerosis)
Source: Atherosclerosis - September 17, 2021 Category: Cardiology Authors: Thabo Mahendiran, Roland Klingenberg, David Nanchen, Baris Gencer, David Meier, Lorenz R äber, David Carballo, Christian M. Matter, Thomas F. Lüscher, François Mach, Nicolas Rodondi, Olivier Muller, Stephane Fournier Source Type: research

Bone metabolism and cardiovascular disease: An overlooked association?
A growing body of evidence suggests that bone mineral metabolism is linked with cardiovascular disease (CVD) [1]. While confirming a statistically significant association between bone mineral density (BMD) and cardiac valve calcification (CVC), the findings reported by Massera et al. [2] question the clinical relevance of bone mineral derangements as promoter of cardiovascular disease in the general population. In their study, the association between progression of CVC and mineral metabolism was modest and substantially modified by sex, race and renal function. (Source: Atherosclerosis)
Source: Atherosclerosis - September 15, 2021 Category: Cardiology Authors: Antonio Bellasi, Paolo Raggi Tags: Editorial Source Type: research

Reply to: “Mortality and in-stent thrombosis in COVID-19 patients with STEMI: More work ahead”
In the letter to the Editor by Zuin et al. [1], the authors raise several interesting points concerning the uncertainties linking coronavirus disease 2019 (COVID-19) to thrombosis, especially in the settings of acute coronary syndromes (ACS). (Source: Atherosclerosis)
Source: Atherosclerosis - September 15, 2021 Category: Cardiology Authors: Monica Verdoia, Giuseppe De Luca Source Type: research

Hemoglobin concentration, hematocrit and red blood cell count predict major adverse cardiovascular events in patients with familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a genetic disease associated with an important risk of premature and recurrent atherosclerotic cardiovascular disease (ASCVD). Red blood cell (RBC) parameters such as cell count and hematocrit (HCT) have previously been associated with ASCVD risk in the general population. However, little is known concerning their effect in FH. The aim of the present study is to investigate the effect of the different RBC parameters on the incidence of major adverse cardiovascular events (MACE) in FH patients. (Source: Atherosclerosis)
Source: Atherosclerosis - September 14, 2021 Category: Cardiology Authors: Martine Paquette, Sophie Bernard, Alexis Baass Source Type: research

Modest decrease in severity of obesity in adolescence associates with low arterial stiffness
Childhood obesity is associated with cardiovascular risk factors (CVRF), subclinical cardiovascular phenotypes (carotid intima-media thickness, cIMT; pulse-wave velocity, PWV; and carotid elasticity), and adult cardiovascular disease (CVD) mortality. In youth with obesity (body mass index, BMI ≥95th centile), we investigated associations between change in adiposity and CVRF from early adolescence and subclinical cardiovascular phenotypes in late adolescence. (Source: Atherosclerosis)
Source: Atherosclerosis - September 13, 2021 Category: Cardiology Authors: Christoph Saner, Tomi T. Laitinen, Joel Nuotio, Sarah J. Arnup, Brooke E. Harcourt, Siroon Bekkering, Zoe McCallum, Kung-Ting Kao, Marco Janner, Costan G. Magnussen, Matthew A. Sabin, Markus Juonala, David P. Burgner Source Type: research

The metabolomic profile of carotid artery intima-media thickness and echogenicity
In this study, the aim was to use multi-modal mass spectroscopy (MS) to relate multiple metabolites from different chemical classes to IMT and also to the echogenicity of the intima-media complex (IM-GSM). (Source: Atherosclerosis)
Source: Atherosclerosis - September 13, 2021 Category: Cardiology Authors: Lars Lind Source Type: research

Characteristics of atherosclerosis in femoropopliteal artery and its clinical relevance
Atherosclerosis is a systemic disease with different faces. Despite identical or similar pathogenetic mechanisms, atherosclerotic lesions and their clinical manifestations vary in different parts of the vascular system. Peripheral arterial disease (PAD) represents one of the most frequent clinical manifestations of atherosclerosis with predominant location in the superficial femoral artery (SFA). Morphological characteristics of atherosclerotic plaques in peripheral arteries differ from lesions in the coronary and carotid arteries. (Source: Atherosclerosis)
Source: Atherosclerosis - September 10, 2021 Category: Cardiology Authors: Pavel Poredo š, Matija Cevc, Aleš Blinc Source Type: research

A systematic review and meta-analysis on the effects of statins on pregnancy outcomes
Statins are contraindicated in pregnancy, due to their potential teratogenicity. However, data are still inconsistent and some even suggest a potential benefit of statin use against pregnancy complications. We aimed to investigate the effects of statins on pregnancy outcomes, including stillbirth, fetal abortion, and preterm delivery, through a systematic review of the literature and a meta-analysis of the available clinical studies. (Source: Atherosclerosis)
Source: Atherosclerosis - September 9, 2021 Category: Cardiology Authors: Amir Vahedian-Azimi, Vanessa Bianconi, Somayeh Makvandi, Maciej Banach, Seyedeh Momeneh Mohammadi, Matteo Pirro, Amirhossein Sahebkar Source Type: research

Glucose as a modifiable cause of atherosclerotic cardiovascular disease: Insights from type 1 diabetes and transplantation
Diabetes is a major risk factor for cardiovascular (CV) disease. In contrast to the clear benefits from treatments which reduce blood pressure and lipids, clinical trials targeting blood glucose have not shown clear CV benefits. Interventions to intensify glycemic control early in the course of diabetes may have benefits in long term observational studies (DCCT-EDIC/UKPDS), but may not be helpful if introduced late in the course of type 2 diabetes (ACCORD, ADVANCE, VA-DT). More recent CVOT in high risk subjects suggest that the benefits of SGLT2 and GLP1-RA are glucose-independent. (Source: Atherosclerosis)
Source: Atherosclerosis - September 8, 2021 Category: Cardiology Authors: Peter A. Senior Source Type: research

Chronic kidney disease measures for cardiovascular risk prediction
Chronic kidney disease (CKD) affects 15 –20% of adults globally and causes various complications, one of the most important being cardiovascular disease (CVD). CKD has been associated with many CVD subtypes, especially severe ones like heart failure, independent of potential confounders such as diabetes and hypertension. There is no con sensus in major clinical guidelines as to how to incorporate the two key measures of CKD (glomerular filtration rate and albuminuria) for CVD risk prediction. This is a critical missed opportunity to appropriately refine predicted risk and personalize prevention therapies according to...
Source: Atherosclerosis - September 8, 2021 Category: Cardiology Authors: Yejin Mok, Shoshana H. Ballew, Kunihiro Matsushita Source Type: research

Sarcopenic obesity at the crossroad of pathogenesis of cardiometabolic diseases
In the past 30 years, obesity and ectopic fat have increasingly been associated with cardiovascular disease widening the construct of cardiometabolic diseases (CMD), which include dyslipidemia, diabetes mellitus, the metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) [1]. Only recently, more attention has also been paid to muscle mass and sarcopenia [2]. (Source: Atherosclerosis)
Source: Atherosclerosis - September 6, 2021 Category: Cardiology Authors: Giovanni Guaraldi, Jovana Milic, Giada Sebastiani, Paolo Raggi Tags: Editorial Source Type: research

Reply to: “Correspondence to: “Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors””
In response to Dr. Dobiasova ’s letter to the editor [1], we take the opportunity to reiterate the importance of using units of the international system (SI) when reporting scientific data. It is of paramount importance to enable comparability of results presented in different articles, but also to facilitate exchange of info rmation between the whole, global scientific community. Atherosclerosis requires authors to express units following the international system or to provide conversion factors into SI units (as indicated in the Guide for authors) and in the submission checklist to be filled in at submission of all...
Source: Atherosclerosis - September 4, 2021 Category: Cardiology Authors: Simona Negrini, Arnold von Eckardstein Source Type: research

Correspondence to: “Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors”
In their paper published in Atherosclerosis, the authors showed that AIP- atherogenic index of plasma is an independent, most sensitive biomarker of atherogenic diseases, which is in agreement with approximately two thousand studies described since 2001 [1]. (Source: Atherosclerosis)
Source: Atherosclerosis - September 3, 2021 Category: Cardiology Authors: Milada Dobiasova Tags: Correspondence Source Type: research

Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study
The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort. (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2021 Category: Cardiology Authors: Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada, for the Japan Public Health Center-based Prospective Study Group Source Type: research

Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia
Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women. (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2021 Category: Cardiology Authors: Marianne Klevmoen, Martin P. Bogsrud, Kjetil Retterst øl, Tone Svilaas, Elisabeth K. Vesterbekkmo, Anders Hovland, Christ Berge, Jeanine Roeters van Lennep, Kirsten B. Holven Source Type: research

Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - September 1, 2021 Category: Cardiology Source Type: research

The difference between cystatin C- and creatinine-based eGFR is associated with adverse cardiovascular outcome in patients with chronic kidney disease
Decreased kidney function is an important risk factor for cardiovascular disease (CVD). However, assessing risk of CVD may be difficult when there is a gap between creatinine- and cystatin C-based estimated glomerular filtration rate (eGFR). We studied the association of the difference in eGFRs with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD). (Source: Atherosclerosis)
Source: Atherosclerosis - August 27, 2021 Category: Cardiology Authors: Hyoungnae Kim, Jung Tak Park, Joongyub Lee, Ji Yong Jung, Kyu-Beck Lee, Yeong-Hoon Kim, Tae-Hyun Yoo, Shin-Wook Kang, Kyu Hun Choi, Kook-Hwan Oh, Curie Ahn, Seung Hyeok Han, KNOW-CKD investigators Source Type: research

Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system
Apolipoprotein M (apoM) is a member of the lipocalin superfamily and is predominantly associated with high-density lipoprotein (HDL). It was found that apoM is the chaperon to the bioactive sphingolipid, sphingosine-1-phosphate (S1P). Several studies have since contributed to expand the knowledge on apoM, S1P, and the apoM/S1P-complex in cardiovascular diseases. For instance, the HDL-bound apoM/S1P complex serves as a bridge between HDL and endothelial cells, maintaining a healthy endothelial barrier. (Source: Atherosclerosis)
Source: Atherosclerosis - August 26, 2021 Category: Cardiology Authors: Ingrid Yao Mattisson, Christina Christoffersen Source Type: research

Impact of sarcopenic obesity on long-term clinical outcomes after ST-segment elevation myocardial infarction
Both low appendicular skeletal muscle index (ASMI) and specific abdominal fat composition [i.e., increased visceral to subcutaneous (V/S) fat ratio] have been associated with cardiovascular events. However, the combined impact of these 2 components on long-term outcomes remains unclear, especially in patients with ST-segment elevation myocardial infarction (STEMI). (Source: Atherosclerosis)
Source: Atherosclerosis - August 26, 2021 Category: Cardiology Authors: Ryosuke Sato, Kozo Okada, Eiichi Akiyama, Masaaki Konishi, Yasushi Matsuzawa, Hidefumi Nakahashi, Yugo Minamimoto, Yuichiro Kimura, Nobuhiko Maejima, Noriaki Iwahashi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura Source Type: research

Bone mineral density and long-term progression of aortic valve and mitral annular calcification: The Multi-Ethnic Study of Atherosclerosis
Bone and mineral metabolism has been implicated in the pathophysiology of cardiac valve calcification. Whether bone demineralization, a common aging-related disorder, promotes calcific valve disease remains uncertain. We tested the hypothesis that low bone mineral density (BMD) is associated with greater incidence/progression of cardiac valve calcification in the Multi-Ethnic Study of Atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - August 25, 2021 Category: Cardiology Authors: Daniele Massera, Petra Buzkova, Anna E. Bortnick, David S. Owens, SongShou Mao, Dong Li, Ian H. De Boer, Bryan R. Kestenbaum, Matthew J. Budoff, Jorge R. Kizer Source Type: research

Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies
This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. (Source: Atherosclerosis)
Source: Atherosclerosis - August 25, 2021 Category: Cardiology Authors: Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama Source Type: research

Promoting athero-protective immunity by vaccination with low density lipoprotein-derived antigens
Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be insufficient other more potent pro-inflammatory immune responses instead contributing to disease progression will gradually become dominant. The importance of the balance between protective and pathogenic immunity is particularly apparent when it comes to the adaptive immune syst...
Source: Atherosclerosis - August 25, 2021 Category: Cardiology Authors: Jan Nilsson, PredimanK.Shah Source Type: research

Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study
Central and Eastern Europe (CEE) is a largely understudied region, despite having the highest cardiovascular disease mortality in Europe. This analysis aimed to assess the proportion of patients in CEE who achieved their LDL-C goals based on individual cardiovascular risk recommended by the 2016 and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines. (Source: Atherosclerosis)
Source: Atherosclerosis - August 25, 2021 Category: Cardiology Authors: Michal Vrablik, Bohumil Seifert, Alexander Parkhomenko, Maciej Banach, Jacek J. J óźwiak, Robert Gabor Kiss, Dan Gaita, Katarina Rašlová, Marie Zachlederova, Sarah Bray, Kausik K. Ray Source Type: research

Implications of the 2019 American college of Cardiology/American heart association Primary Prevention Guidelines and potential value of the coronary artery calcium score among South Asians in the US: The mediators of atherosclerosis in South Asians living in America (MASALA) study
South Asian (SA) ethnicity is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). However, the implications of considering SA ethnicity as a “risk-enhancing factor” per recent American College of Cardiology/American Heart Association guidelines are not fully understood. (Source: Atherosclerosis)
Source: Atherosclerosis - August 23, 2021 Category: Cardiology Authors: Waqas Haque, Gowtham R. Grandhi, Alka M. Kanaya, Namratha R. Kandula, Khurram Nasir, Mahmoud Al Rifai, S.M. Iftekhar Uddin, Ugo Fedeli, Naveed Sattar, Roger S. Blumenthal, Michael J. Blaha, Miguel Cainzos-Achirica Source Type: research

Lipoprotein(a) in hereditary hypercholesterolemia: Influence of the genetic cause, defective gene and type of mutation
Lipoprotein(a) [Lp(a)] concentration in heterozygous familial hypercholesterolemia (heFH) is not well established. Whether the genetic defect responsible for heFH plays a role in Lp(a) concentration is unknown.We aimed to compare Lp(a) in controls from a healthy population, in genetically diagnosed heFH and mutation-negative hypercholesterolemia subjects, and to assess the influence on Lp(a) of the genetic defect responsible for heFH. (Source: Atherosclerosis)
Source: Atherosclerosis - August 22, 2021 Category: Cardiology Authors: Victoria Marco-Bened í, Ana Cenarro, Martín Laclaustra, Asier Larrea-Sebal, Estíbaliz Jarauta, Itziar Lamiquiz-Moneo, Pilar Calmarza, Ana M. Bea, Núria Plana, Xavier Pintó, César Martín, Fernando Civeira Source Type: research

Impact of a coronary artery calcium-guided statin treatment protocol on cardiovascular risk at 12 months: Results from a pragmatic, randomised controlled trial
This study sought to evaluate the benefit of a CAC-guided risk-management protocol in those with a family history of premature coronary artery disease (FHCAD). (Source: Atherosclerosis)
Source: Atherosclerosis - August 22, 2021 Category: Cardiology Authors: Prasanna Venkataraman, Quan Huynh, Stephen J. Nicholls, Tony Stanton, Gerald F. Watts, Thomas H. Marwick, CAUGHT-CAD investigators Source Type: research

Lipoprotein(a) in hereditary hypercholesterolemia. Influence of the genetic cause, defective gene and type of mutation
Lipoprotein(a) [Lp(a)] concentration in heterozygous familial; hypercholesterolemia (heFH) is not well established. Whether the genetic defect responsible for heFH plays a role in Lp(a) concentration is unknown.We aimed to compare Lp(a) in controls from a healthy population, in genetically diagnosed heFH and mutation-negative hypercholesterolemia subjects, and to assess the influence on Lp(a) of the genetic defect responsible for heFH. (Source: Atherosclerosis)
Source: Atherosclerosis - August 22, 2021 Category: Cardiology Authors: Victoria Marco-Bened í, Ana Cenarro, Martín Laclaustra, Asier Larrea-Sebal, Estíbaliz Jarauta, Itziar Lamiquiz-Moneo, Pilar Calmarza, Ana M. Bea, Núria Plana, Xavier Pintó, César Martín, Fernando Civeira Source Type: research

Comparative performance of the two pooled cohort equations for predicting atherosclerotic cardiovascular disease
This study aims to compare the accuracy of both PCE in predicting the ASCVD risk within a large, real-world patient population in the US. (Source: Atherosclerosis)
Source: Atherosclerosis - August 21, 2021 Category: Cardiology Authors: Alessandra M. Campos-Staffico, David Cordwin, Venkatesh L. Murthy, Michael P. Dorsch, Jasmine A. Luzum Source Type: research

Added prognostic value of plaque burden to computed tomography angiography and myocardial perfusion imaging
Cardiac computed tomographic angiography (CCTA) - derived measures of coronary artery disease (CAD) burden have been shown to independently predict incident cardiovascular events. We aimed to compare the added prognostic value of plaque burden to CCTA anatomic assessment and single photon emission computed tomography (SPECT) physiologic assessment in a cohort with high prevalence of risk factors undergoing both tests. (Source: Atherosclerosis)
Source: Atherosclerosis - August 18, 2021 Category: Cardiology Authors: Ahmed Ibrahim Ahmed, Yushui Han, Mahmoud Al Rifai, Talal Alnabelsi, Faisal Nabi, Su Min Chang, Mohammed A. Chamsi-Pasha, Khurram Nasir, John J. Mahmarian, Miguel Cainzos-Achirica, Mouaz H. Al-Mallah Source Type: research

Title: Added prognostic value of plaque burden to computed tomography angiography and myocardial perfusion imaging
Cardiac computed tomographic angiography (CCTA) - derived measures of coronary artery disease (CAD) burden have been shown to independently predict incident cardiovascular events. We aimed to compare the added prognostic value of plaque burden to CCTA anatomic assessment and single photon emission computed tomography (SPECT) physiologic assessment in a cohort with high prevalence of risk factors undergoing both tests. (Source: Atherosclerosis)
Source: Atherosclerosis - August 18, 2021 Category: Cardiology Authors: Ahmed Ibrahim Ahmed, Yushui Han, Mahmoud Al Rifai, Talal Alnabelsi, Faisal Nabi, Su Min Chang, Mohammed A. Chamsi-Pasha, Khurram Nasir, John J. Mahmarian, Miguel Cainzos-Achirica, Mouaz H. Al-Mallah Source Type: research

Statin initiation and all-cause mortality in incident statin-na ïve dialysis patients
Cardiovascular disease is the main cause of death in end-stage kidney disease (ESKD) patients. We aimed to explore the association between statin initiation after starting dialysis and all-cause mortality in statin-na ïve ESKD patients. (Source: Atherosclerosis)
Source: Atherosclerosis - August 17, 2021 Category: Cardiology Authors: Ji Eun Kim, Sehoon Park, Myeong-seok Kim, Sung Jin Kang, Jang Wook Lee, Kwang Soo Kim, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Minsu Park, Hajeong Lee Source Type: research

Macrophage metabolic regulation in atherosclerotic plaque
Metabolism plays a key role in controlling immune cell functions. In this review we will discuss the diversity of plaque resident myeloid cells and will focus on their metabolic demands that could reflect on their particular intraplaque localization. Defining the metabolic configuration of plaque resident myeloid cells according to their topologic distribution could provide answers to key questions regarding their functions and contribution to disease development. (Source: Atherosclerosis)
Source: Atherosclerosis - August 16, 2021 Category: Cardiology Authors: Bastien Dolfi, Alexandre Gallerand, Arvand Haschemi, Rodolphe R. Guinamard, Stoyan Ivanov Source Type: research

Intracranial aneurysm is predicted by abdominal aortic calcification index: A retrospective case-control study
Patients with intracranial aneurysms (IA) have excess mortality for cardiovascular diseases, but little is known on whether atherosclerotic manifestations and IA coexist. We investigated abdominal aortic calcification index's (ACI) association with unruptured and ruptured IAs. (Source: Atherosclerosis)
Source: Atherosclerosis - August 14, 2021 Category: Cardiology Authors: Ville Rantasalo, Jarmo Gunn, Tuomas Kiviniemi, Jussi Hirvonen, Ilkka Saarenp ää, Juri Kivelev, Melissa Rahi, Elli Lassila, Jaakko Rinne, Dan Laukka Source Type: research

Lipid-rich plaques detected by near-infrared spectroscopy predict coronary events irrespective of age: A Lipid Rich Plaque sub-study
In this Lipid Rich Plaque (LRP) sub-study, 1551 patients undergoing coronary angiography for acute coronary syndromes or stable angina were examined with near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS). We aimed to assess the correlation of patient age with the presence of high-risk plaques, defined as maximum 4-mm Lipid Core Burden Index (maxLCBI4mm)  > 400 and plaque burden>70%, and 2-year incidence of non-culprit major adverse cardiovascular events (NC-MACE). (Source: Atherosclerosis)
Source: Atherosclerosis - August 14, 2021 Category: Cardiology Authors: Gabriele Bambagioni, Carlo Di Mario, Rebecca Torguson, Pierluigi Demola, Ziad Ali, Varinder Singh, William Skinner, Andre Artis, Tim ten Cate, Cheng Zhang, Hector M. Garcia-Garcia, Gheorghe Doros, Gary S. Mintz, Ron Waksman Source Type: research

Symptomatic and asymptomatic peripheral artery disease and the risk of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities (ARIC) study
Symptomatic peripheral artery disease (PAD) is a risk factor for abdominal aortic aneurysm (AAA). However, data on the association of asymptomatic PAD with AAA are limited. We explored the association of symptomatic and asymptomatic PAD with AAA. (Source: Atherosclerosis)
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: Caitlin W. Hicks, Ada Al-Qunaibet, Ning Ding, Lucia Kwak, Aaron R. Folsom, Hirofumi Tanaka, Thomas Mosley, Lynne E. Wagenknecht, Weihong Tang, Gerardo Heiss, Kunihiro Matsushita Source Type: research

Lipid Clinics Network targets suboptimal guideline implementation
The European Atherosclerosis Society (EAS) continues to respond to the needs of the global community and address issues in dyslipidaemia management. The first of several ‘linked-up’ EAS initiatives is the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry, launched in 2015, which aimed to address the inadequacy of FH detection and care across the globe [1]. This was followed one year later by EAS support for the initiation of the Homozygous Fam ilial Hypercholesterolaemia International Clinical Collaboration (HICC) registry, which created an international network of healthcare providers involv...
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: Jane Stock Source Type: research

Fasting lipids are not a good way to assess the effects of diet on cardiovascular risk
The recent paper by Griffin et al. [1] published in Atherosclerosis suggests that genetically determined variation in the response of fasting low-density lipoprotein cholesterol (LDL-C) to saturated fat informs the issue of whether dietary saturated fat increases cardiovascular risk. This is probably true, but a focus on fasting LDL-C, though common, is not a good way to assess the effect of diet on cardiovascular risk. (Source: Atherosclerosis)
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: J. David Spence Source Type: research

Time for sex specific atherosclerosis risk prediction
This study makes a significant contribution to the growing body of literature to better understand coronary artery disease (CAD) risk factors in women in order to improve detection and early, personalized interventions. It demonstrated a surprising finding though; smoking and diabetes mellitus, previously thought to be associated with CAD in women, were not associated with the presence of atherosclerotic plaque in coronary arteries. (Source: Atherosclerosis)
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: Hyeon ‐Ju Ali, Mouaz H. Al-Mallah Source Type: research

Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation
When endothelium is cultured in wells swirled on an orbital shaker, cells at the well centre experience putatively pro-atherogenic flow whereas those near the edge experience putatively atheroprotective flow. Transcellular transport is decreased equally in both regions, consistent with it being reduced by a mediator released from cells in one part of the well and mixed in the swirling medium. Similar effects have been reported for pro-inflammatory changes. Here we identify the mediator and the flow characteristics that stimulate its release. (Source: Atherosclerosis)
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: Mean Ghim, Kuin T. Pang, Sean A. Burnap, Ferheen Baig, Xiaoke Yin, Mehwish Arshad, Manuel Mayr, Peter D. Weinberg Source Type: research

Phenylacetylglutamine is associated with the degree of coronary atherosclerotic severity assessed by coronary computed tomographic angiography in patients with suspected coronary artery disease
In this study, we analyzed the relationship between plasma PAG and coronary atherosclerotic severity assessed by coronary computed tomographic angiography (CCTA). (Source: Atherosclerosis)
Source: Atherosclerosis - August 13, 2021 Category: Cardiology Authors: Yang Liu, Shaoyan Liu, Zhizhuang Zhao, Xiang Song, Haixian Qu, Hongbin Liu Source Type: research

Deletion of Fam172a accelerates advanced atherosclerosis and induces plaque instability
Vascular smooth muscle cells (VSMCs) play a critical role in atherosclerosis. The family with sequence similarity 172, member A (FAM172A) is a novel protein and its role in atherosclerosis has not been explored so far. Therefore, our aim is to investigate whether FAM172A affects atheroprogression through VSMCs and its possible mechanism. (Source: Atherosclerosis)
Source: Atherosclerosis - August 12, 2021 Category: Cardiology Authors: Ming-Yun Chen, Jiang-Feng Ke, Zhi-Hui Zhang, Mei-Fang Li, Jun-Wei Wang, Jun-Xi Lu, Pei-Pei Xu, Xiao-Tian Xia, Ming-Gao Guo, Lian-Xi Li Source Type: research