Lipoprotein (a) and aortic valve calcium in South Asians compared to other race/ethnic groups
South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. (Source: Atherosclerosis)
Source: Atherosclerosis - September 18, 2020 Category: Cardiology Authors: Minhal Makshood, Parag H. Joshi, Alka M. Kanaya, Colby Ayers, Matthew Budoff, Michael Y. Tsai, Michael Blaha, Erin D. Michos, Wendy S. Post Source Type: research

Alcohol consumption patterns across Europe and adherence to the European guidelines in coronary patients: Findings from the ESC-EORP EUROASPIRE V survey
Alcohol consumption is an important risk factor for cardiovascular morbidity and mortality worldwide. The highest levels of alcohol consumption are observed in Europe, where alcohol as contributing cause of coronary heart disease (CHD) is also most significant. We aimed to describe alcohol consumption patterns across European regions and adherence to the current guidelines in patients with a recent CHD event. (Source: Atherosclerosis)
Source: Atherosclerosis - September 17, 2020 Category: Cardiology Authors: Inge A.T. van de Luitgaarden, Ilse C. Schrieks, Dirk De Bacquer, Sabine van Oort, Erkin Mirrakhimov, Nana Pogosova, Kairat Davletov, Maryna Dolzhenko, Adriana J. van Ballegooijen, Kornelia Kotseva, Diederick E. Grobbee, Joline W.J. Beulens, EUROASPIRE V i Source Type: research

Long noncoding RNA ZNF800 suppresses proliferation and migration of vascular smooth muscle cells by upregulating PTEN and inhibiting AKT/mTOR/HIF-1 α signaling
This study aimed to investigate the potential effects of lncRNA ZNF800, a previously uncharacterized lncRNA, on VSMC proliferation and migration. (Source: Atherosclerosis)
Source: Atherosclerosis - September 14, 2020 Category: Cardiology Authors: Yuan-Bin Lu, Chao Shi, Biao Yang, Zhi-Feng Lu, Yi-Lin Wu, Ru-Yi Zhang, Xin He, Li-Min Li, Bing Hu, Yan-Wei Hu, Lei Zheng, Qian Wang Source Type: research

Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK
The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes Coronavirus Disease 2019 (COVID-19) has resulted in a worldwide pandemic. SARS-CoV-2 is highly contagious and its severity highly variable. The fatality rate is unpredictable but is amplified by several factors including advancing age, atherosclerotic cardiovascular disease, diabetes mellitus, hypertension and obesity. A large proportion of patients with these conditions are treated with lipid lowering medication and questions regarding the safety of continuing lipid-lowering medication in patients infected with COVID-19 ha...
Source: Atherosclerosis - September 14, 2020 Category: Cardiology Authors: Zohaib Iqbal, Jan Hoong Ho, Safwaan Adam, Michael France, Akheel Syed, Dermot Neely, Alan Rees, Rani Khatib, Jaimini Cegla, Christopher Byrne, Nadeem Qureshi, Nigel Capps, Gordon Ferns, Jules Payne, Jonathan Schofield, Kirsty Nicholson, Dev Datta, Alison Tags: Review article Source Type: research

Low plantar skin perfusion pressure predicts long-term atherosclerotic vascular events and mortality in maintenance haemodialysis patients
End-stage renal disease is associated with an increased risk of atherosclerotic vascular disease (AVD). We investigated whether low plantar skin perfusion pressure (SPP), a useful indicator of peripheral arterial disease (PAD), predicts systemic AVD events and mortality in outpatients undergoing maintenance haemodialysis (HD). (Source: Atherosclerosis)
Source: Atherosclerosis - September 13, 2020 Category: Cardiology Authors: Maki Hiratsuka, Katsushi Koyama, Hiroshi Takahashi, Takahisa Kasugai, Junichiro Hagita, Akihito Kondo, Kiyomi Koike, Takayuki Hamano Source Type: research

Subclinical macro and microvascular disease is differently associated with depressive symptoms in men and women: Findings from the SABRE population-based study
Mechanisms underlying the association between cardiovascular disease (CVD) and depression are unknown, and sex differences understudied. We investigated associations between a comprehensive set of measures of macro and microvascular disease and depressive symptoms in older men and women. (Source: Atherosclerosis)
Source: Atherosclerosis - September 12, 2020 Category: Cardiology Authors: Jingyi Wang, Therese Tillin, Alun D. Hughes, Marcus Richards, Naveed Sattar, Chloe Park, Nish Chaturvedi Source Type: research

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?
Alterations in composition and function of the gut microbiota have been demonstrated in diseases involving the cardiovascular system, particularly coronary heart disease and atherosclerosis. The data are still limited but the typical altered genera include Roseburia and Faecalibacterium. Plausible mechanisms by which microbiota may mediate cardio-protective effects have been postulated, including the production of metabolites like TMA, as well as immunomodulatory functions. This raises the question of whether it is possible to modify the gut microbiota by lifestyle interventions and thereby improve cardiovascular health. (...
Source: Atherosclerosis - September 11, 2020 Category: Cardiology Authors: Victor Gerdes, Miguel Gueimonde, Lotta Pajunen, Max Nieuwdorp, Kirsi Laitinen Source Type: research

Differences in HDL particle size in the presence of subclinical thyroid dysfunctions: The ELSA-Brasil study
Thyroid dysfunction is related to several lipid abnormalities. There is no consensus about concentration of high-density lipoprotein (HDL) in different studies. The aim of this report is to evaluate HDL particle (HDL-P) subfractions across a spectrum of thyroid function in a Brazilian population. (Source: Atherosclerosis)
Source: Atherosclerosis - September 10, 2020 Category: Cardiology Authors: Carolina Castro Porto Silva Janovsky, Giuliano Generoso, Alessandra C. Goulart, Raul D. Santos, Michael J. Blaha, Steven Jones, Peter P. Toth, Paulo A. Lotufo, Marcio Sommer Bittencourt, Isabela M. Bense ñor Source Type: research

Carotid stent occlusion after emergent stenting in acute ischemic stroke: Incidence, predictors and clinical relevance
Emergent stent placement may be required during neurothrombectomy. Our aim was to investigate the incidence, predictors and clinical relevance of early extracranial carotid stent occlusion following neurothrombectomy. (Source: Atherosclerosis)
Source: Atherosclerosis - September 10, 2020 Category: Cardiology Authors: Arturo Ren ú, Jordi Blasco, Carlos Laredo, Laura Llull, Xabier Urra, Victor Obach, Antonio López-Rueda, Salvatore Rudilosso, Federico Zarco, Elisabet González, José David Guio, Sergio Amaro, Angel Chamorro Source Type: research

Visit-to-visit variability of lipid measurements and the risk of myocardial infarction and all-cause mortality: A prospective cohort study
Previous studies suggested that increased visit-to-visit variability in lipid measurements is associated with cardiovascular disease in specific or high-risk populations. Because it is unknown whether this notion applies to the general population, we investigated whether lipid variability has additive effects on the risk of all-cause mortality and myocardial infarction (MI) in the general population. (Source: Atherosclerosis)
Source: Atherosclerosis - September 9, 2020 Category: Cardiology Authors: Xiaoxue Liu, Shouling Wu, Qiaofeng Song, Xizhu Wang Source Type: research

Endothelial shear stress and vascular remodeling in bioresorbable scaffold and metallic stent
a: The impact of endothelial shear stress (ESS) on vessel remodeling in vessels implanted with bioresorbable scaffold (BRS) as compared to metallic drug-eluting stent (DES) remains elusive. The aim of this study was to determine whether the relationship between ESS and remodeling patterns differs in BRS from those seen in metallic DES at 3-year follow-up. (Source: Atherosclerosis)
Source: Atherosclerosis - September 9, 2020 Category: Cardiology Authors: Erhan Tenekecioglu, Yuki Katagiri, Kuniaki Takahashi, Mariusz Tomaniak, Dariusz Dudek, Angel Cequier, Didier Carri é, Andrés Iñiguez, Rinse Johannes van der Schaaf, Marcello Dominici, Ad J.van Boven, Steffen Helqvist, Manel Sabaté, Andreas Baumbach, J Source Type: research

Associations between plasma ceramides and mortality in patients with coronary artery disease
The relationship between ceramides and the risk of mortality among patients with coronary artery disease (CAD) is currently relatively sparse. This prospective study aimed to clarify whether plasma ceramides are associated with greater risks of cardiovascular and all-cause mortality among CAD patients. (Source: Atherosclerosis)
Source: Atherosclerosis - September 9, 2020 Category: Cardiology Authors: Qing Li, Xu Wang, Juan Pang, Yuan Zhang, Hanyue Zhang, Zhongliang Xu, Qian Chen, Wenhua Ling Source Type: research

Homozygous familial hypercholesterolemia in Italy: Clinical and molecular features
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by extremely elevated plasma levels of low density lipoprotein cholesterol (LDL-C) and high risk of premature atherosclerotic cardiovascular disease (ASCVD). HoFH is caused by pathogenic variants in several genes, such as LDLR, APOB and PCSK9 responsible for autosomal dominant hypercholesterolemia (ADH) and LDLRAP1 responsible for autosomal recessive hypercholesterolemia (ARH). Aim of this study was the review of the clinical and molecular features of patients with HoFH identified in Italy from 1989 to 2019. (Source: Atherosclerosis)
Source: Atherosclerosis - September 8, 2020 Category: Cardiology Authors: Stefano Bertolini, Sebastiano Calandra, Marcello Arca, Maurizio Averna, Alberico L. Catapano, Patrizia Tarugi, The ItalianStudy Group of Homozygous Familial Hypercholesterolemia Source Type: research

Association of gout with major adverse cardiovascular events and all-cause mortality in patients with peripheral artery disease
Prior epidemiological studies have suggested that individuals with gout are at greater risk of cardiovascular events, but there have been no studies in people with peripheral artery disease (PAD). The aim of this study was to investigate the relationship between gout and major adverse cardiovascular events (MACE) and all-cause mortality in people with PAD. (Source: Atherosclerosis)
Source: Atherosclerosis - September 8, 2020 Category: Cardiology Authors: Tejas P. Singh, Shannon Wong, Frank Quigley, Jason Jenkins, Jonathan Golledge Source Type: research

Lipoprotein(a) and cardiovascular death in oldest-old ( ≥80 years) patients with acute myocardial infarction: A prospective cohort study
Compared with what is known about the prognostic value of lipoprotein(a) [Lp(a)] in middle-aged patients with atherosclerotic cardiovascular disease (ASCVD), less is understood concerning the role of Lp(a) in oldest-old ( ≥80 years old) with ASCVD. The aim of the present study was to investigate the relationship between Lp(a) and cardiovascular death (CD) among the oldest-old with acute myocardial infarction (AMI). (Source: Atherosclerosis)
Source: Atherosclerosis - September 8, 2020 Category: Cardiology Authors: Meng Zhang, Hui-Hui Liu, Jing-Lu Jin, Xiao-Ni Yan, Qian Dong, Jian-Jun Li Source Type: research

Formation of atherosclerotic lesions is independent of eosinophils in male mice
Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a potential role of type 2 immunity in atherogenesis. However, the involvement of individual type 2 immune cell subsets involved in this process has been incompletely defined. We therefore sought to determine the role of eosinophils during LDL oxidation and the pathogenesis of this disease. (Source: Atherosclerosis)
Source: Atherosclerosis - September 7, 2020 Category: Cardiology Authors: Katharina Hofheinz, Fabian Seibert, Jochen A. Ackermann, Barbara Dietel, Miyuki Tauchi, Maria Oszvar-Kozma, Hartmut K ühn, Georg Schett, Christoph J. Binder, Gerhard Krönke Source Type: research

Predicted impact of increasing average ambient temperature over the coming century on mortality from cardiovascular disease and stroke in the USA
Future climate change may adversely impact human health. The direct effects of extreme hot temperatures on mortality are well established, and their future impact well modelled. However, less extreme changes in ambient temperature (Ta) have been previously associated with increased mortality from circulatory and metabolic diseases, but their future impact is less clear. (Source: Atherosclerosis)
Source: Atherosclerosis - September 7, 2020 Category: Cardiology Authors: Mohsen Mazidi, John R. Speakman Source Type: research

Acidic extracellular pH promotes accumulation of free cholesterol in human monocyte-derived macrophages via inhibition of ACAT1 activity
In focal areas of advanced human atherosclerotic lesions, the intimal fluid is acidic. An acidic medium impairs the ABCA1-mediated cholesterol efflux from macrophages, so tending to increase their content of free cholesterol, which is then available for esterification by the macrophage enzyme ACAT1. Here we investigated whether low extracellular pH would affect the activity of ACAT1. (Source: Atherosclerosis)
Source: Atherosclerosis - September 7, 2020 Category: Cardiology Authors: Miriam Lee-Rueckert, Jani Lappalainen, Hannele Leinonen, Riia Plihtari, Tommy Nordstr öm, Karl Åkerman, Katariina Öörni, Petri T. Kovanen Source Type: research

Omega-3 fatty acids and risk of cardiovascular disease in Inuit: First prospective cohort study
No prospective study have ever assessed if marine n-3 polyunsaturated fatty acids protect Inuit against cardiovascular disease as claimed. It is highly relevant as cardiovascular disease (CVD) incidence rates are rising concurrent with a westernization of diet. We aimed to assess the association between blood cell membrane phospholipid content of eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) on CVD risk in Inuit. (Source: Atherosclerosis)
Source: Atherosclerosis - September 7, 2020 Category: Cardiology Authors: Ninna K. Senftleber, Anders Albrechtsen, Lotte Lauritzen, Christina Lytken Larsen, Peter Bjerregaard, Lars J. Diaz, Pernille F. R ønn, Marit E. Jørgensen Source Type: research

AHRR hypomethylation as an epigenetic marker of smoking history predicts risk of myocardial infarction in former smokers
Smoking causes cardiovascular disease. AHRR hypomethylation at the cg05575921 site is associated with active and former smoking status at baseline, and cumulative amount of tobacco smoked. We tested the hypothesis that AHRR cg05575921 hypomethylation as an epigenetic marker of smoking history predicts the risk of myocardial infarction in former smokers. (Source: Atherosclerosis)
Source: Atherosclerosis - September 7, 2020 Category: Cardiology Authors: Anne Langsted, Stig E. Bojesen, Erik S.G. Stroes, B ørge G. Nordestgaard Source Type: research

Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study
An inverse relationship between cholesterol and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. (Source: Atherosclerosis)
Source: Atherosclerosis - September 6, 2020 Category: Cardiology Authors: Stephanie L. Harrison, Deirdre A. Lane, Maciej Banach, Miros ław Mastej, Sławomir Kasperczyk, Jacek J. Jóźwiak, Gregory Y.H. Lip, LIPIDOGRAM2015 Investigators Source Type: research

Early life predictors of development of blood pressure from childhood to adulthood: Evidence from a 30-year longitudinal birth cohort study
The early life predictors of changes in the blood pressures of offspring between childhood and young adulthood have not been well defined. Thus, this study aimed to determine the life course association of offspring's blood pressure with prenatal and early infancy lifestyle, and other factors taking advantage of a large community-based, longitudinal study of a birth cohort in Australia – the MUSP study. (Source: Atherosclerosis)
Source: Atherosclerosis - September 5, 2020 Category: Cardiology Authors: Sumon Kumar Das, Harold David McIntyre, Abdullah Al Mamun Source Type: research

Common APOC3 variants are associated with circulating ApoC-III and VLDL cholesterol but not with total apolipoprotein B and coronary artery disease
Very rare loss-of-function mutations in the apolipoprotein C3 (APOC3) gene have been associated with low circulating apoC-III, low triglycerides, and reduced cardiovascular risk. We aimed to analyze the impact of common APOC3 variants on key parameters of lipid metabolism and on coronary artery disease in the largest sample so far. (Source: Atherosclerosis)
Source: Atherosclerosis - September 4, 2020 Category: Cardiology Authors: G ünther Silbernagel, Hubert Scharnagl, Marcus E. Kleber, Michael M. Hoffmann, Graciela Delgado, Tatjana Stojakovic, Thomas Gary, Lingyao Zeng, Andreas Ritsch, Stephen Zewinger, Thimoteus Speer, Heribert Schunkert, Ulf Landmesser, Winfried März, Tanja B Source Type: research

Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis
Shift work is common worldwide and linked to deleterious cardiovascular effects that might be underlined by dyslipidemia. The aim of this systematic review and meta-analysis is to determine the impact of shiftwork on dyslipidemia. (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2020 Category: Cardiology Authors: Fr édéric Dutheil, Julien S. Baker, Martial Mermillod, Mélanie De Cesare, Alexia Vidal, Fares Moustafa, Bruno Pereira, Valentin Navel Source Type: research

Residual inflammatory risk: lessons from trials for the future
Residual cardiovascular risk is multifactorial. Beyond cholesterol, seminal trials have demonstrated the clinical benefit of targeting residual inflammatory risk in high risk patients with well controlled LDL cholesterol levels. This latest commentary discusses evidence from these trials and future therapeutic approaches to residual inflammatory risk. (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2020 Category: Cardiology Authors: Jane Stock Tags: EAS Updates Source Type: research

HDL markers in cardiovascular risk prediction: Ethnicity matters
High-density lipoprotein (HDL) has had a chequered history. Epidemiologic evidence supports HDL cholesterol (HDL-C) as a marker for cardiovascular risk, providing the rationale for its incorporation in SCORE, a cardiovascular risk algorithm (1,2). Investigation of the potential of HDL-targeted therapies to reduce cardiovascular events in high-risk patients has, however, proved disappointing in clinical trials (3-6). (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2020 Category: Cardiology Authors: Jane Stock Tags: EAS Updates Source Type: research

The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) study: subclinical cervico-cerebral stenosis and middle cerebral artery pulsatility index as predictors of long-term incident cognitive impairment
We aimed to study subclinical non-invasive vascular markers as predictors of incident long-term cognitive impairment in a longitudinal population-based study. (Source: Atherosclerosis)
Source: Atherosclerosis - September 2, 2020 Category: Cardiology Authors: A.M. Crespo-Cuevas, T. Canento, M. Hern ández-Perez, C. Cáceres, A. González, L. Ispierto, M. Mataró, D. Vilas, A. Planas-Ballvé, L. Martin, L. Muñoz-Ortiz, J.F. Arenillas, M. Via, M. Castañón, M. Millan, L. Dorado, E. López-Cancio Source Type: research

Editorial board
(Source: Atherosclerosis)
Source: Atherosclerosis - September 1, 2020 Category: Cardiology Source Type: research

Macrophage infiltrates in coronary plaque erosion and cardiovascular outcome in patients with acute coronary syndrome
Plaque erosion (PE) is responsible for at least one-third of acute coronary syndrome (ACS), and inflammation plays a key role in plaque instability. We assessed the presence of optical coherence tomography (OCT)-defined macrophage infiltrates (M ØI) at the culprit site in ACS patients with PE, evaluating their clinical and OCT correlates, along with their prognostic value. (Source: Atherosclerosis)
Source: Atherosclerosis - September 1, 2020 Category: Cardiology Authors: Rocco A. Montone, Vincenzo Vetrugno, Massimiliano Camilli, Michele Russo, Francesco Fracassi, Sohail Q. Khan, Sagar N. Doshi, Jonathan N. Townend, Peter F. Ludman, Carlo Trani, Giampaolo Niccoli, Filippo Crea Source Type: research

Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls.
Abstract Various inflammatory stimuli are able to modify or even "re-program" the mitochondrial metabolism that results in generation of reactive oxygen species. In noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies, type 2 diabetes and metabolic syndrome, these modifications become systemic and are characterized by chronic inflammation and, in particular, "neuroinflammation" in the central nervous system. The processes associated with chronic inflammation are frequently grouped into "vicious circles" which are able to stimulate each other co...
Source: Atherosclerosis - August 30, 2020 Category: Cardiology Authors: Filippov MA, Tatarnikova OG, Pozdnyakova NV, Vorobyov VV Tags: Neural Regen Res Source Type: research

No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels
Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potentially limited efficacy. Patients with very low levels of HDL-cholesterol and impaired cholesterol efflux capacity can be expected to derive the most potential benefit from infusion of HDL mimetics. This randomized clinical trial evaluated the efficacy of infusions of the HDL mimetic CER-001 in patients with genetically determined very low levels of HDL-cholesterol. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Kang H. Zheng, Yannick Kaiser, Casper C. van Olden, Raul D. Santos, Jean-Louis Dasseux, Jacques Genest, Daniel Gaudet, Jan Westerink, Constance Keyserling, Hein J. Verberne, Eran Leitersdorf, Robert A. Hegele, Olivier S. Descamps, Paul Hopkins, Aart J. Ne Source Type: research

The relationship between coronary artery calcium density and optical coherence tomography-derived plaque characteristics
Although coronary artery calcium (CAC) density has been associated with plaque stability, pathological evidence is lacking. We investigated the relationship between coronary computed tomography (CCT)-derived CAC density and multiple calcified and high-risk plaque (HRP) characteristics using optical coherence tomography (OCT). (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Ryo Okubo, Rine Nakanishi, Christopher Dailing, Takayuki Yabe, Ryota Noike, Shingo Matsumoto, Hiroto Aikawa, Yuriko Okamura, Hidenobu Hashimoto, Hideo Amano, Mikihito Toda, Akiko Maehara, Matthew J. Budoff, Takanori Ikeda Source Type: research

Hyperlipidemia does not affect development of elastase-induced abdominal aortic aneurysm in mice
Hyperlipidemia is a suggested risk factor for abdominal aortic aneurysm (AAA). However, whether or not hyperlipidemia is causally involved in AAA progression remains elusive. Here, we tested the hypothesis that hyperlipidemia aggravates AAA formation in the widely used porcine pancreatic elastase (PPE) model of AAA in mice with varying levels of plasma lipids. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Joscha Mulorz, Joshua Michael Spin, Hans Christian Beck, My Linh Tha Thi, Markus Udo Wagenh äuser, Lars Melholt Rasmussen, Jes Sanddal Lindholt, Philip Shih Chung Tsao, Lasse Bach Steffensen Source Type: research

Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease
Coronary artery disease (CAD) arises from the interaction of genetic and environmental factors. Although genome-wide association studies (GWAS) have identified multiple risk loci and single nucleotide polymorphisms (SNPs) associated with risk of CAD, they are predominantly located in non-coding or intergenic regions and their mechanisms of effect are largely unknown. Accordingly, our objective was to develop a data-driven informatics pipeline to understand complex CAD risk loci, and to apply this to a poorly understood cluster of SNPs in the vicinity of ZEB2. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Lijiang Ma, Nirupama Chandel, Raili Ermel, Katyayani Sukhavasi, Ke Hao, Arno Ruusalepp, Johan L.M. Bj örkegren, Jason C. Kovacic Source Type: research

Lifetime risk predictions for cardiovascular diseases: competing risks analyses on a population-based cohort in Sweden
There are guideline discussions on a lifetime approach to cardiovascular risk. Many of the available risk models estimate the short-term, usually 10-year risk of non-fatal and fatal cardiovascular diseases (CVD) grouped together. We aimed to develop lifetime risk models for non-fatal coronary heart disease, stroke, heart failure and death from CVD and non-CVD. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Anna Stenling, Christel H äggström, Margareta Norberg, Fredrik Norström Source Type: research

Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study
We aimed to investigate the association of serum glycated albumin (GA) levels with the risk of cardiovascular disease (CVD) and its subtypes, including coronary heart disease (CHD) and stroke, in a general Japanese population. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Akane Mihara, Tomoyuki Ohara, Jun Hata, Takanori Honda, Sanmei Chen, Satoko Sakata, Emi Oishi, Yoichiro Hirakawa, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya Source Type: research

Mutual regulation between β-TRCP mediated REST protein degradation and Kv1.3 expression control vascular smooth muscle cell phenotype switch
Phenotypic switch of vascular smooth muscle cells (VSMC) plays a key role in the pathogenesis of atherosclerosis and restenosis after artery intervention. Transcription repressor element 1-silencing transcription factor (REST) has been identified as key regulator of VSMC proliferation. In the present study, we sought to investigate the potential association of E3-ubiquitin ligase β-TRCP mediated REST protein degradation with Kv1.3 expression during VSMC phenotypic switch. (Source: Atherosclerosis)
Source: Atherosclerosis - August 29, 2020 Category: Cardiology Authors: Meng Ye, Xiangjiang Guo, Han Wang, Yuli Wang, Xin Qian, Haoyu Deng, Weilun Wang, Shuofei Yang, Qihong Ni, Jiaquan Chen, Lei Lv, Yiping Zhao, Guanhua Xue, Yinan Li, Lan Zhang Source Type: research

Calcified plaque morphology, density, and risk
In this issue of Atherosclerosis, Pugliese et al. investigated associations between stenosis severity, coronary calcium morphology, calcium density and specific coronary plaque ‘vulnerability’ features by computed tomography (CT)1. One hundred symptomatic or asymptomatic patients, undergoing clinical coronary CT angiography (CCTA) and coronary artery calcium score (CACS) for evaluation of known or suspected coronary atherosclerosis and with at least one coronary stenos is, were included. The mean age was 67 years and 74% were male, 21% patients having diabetes, 59% hypertension, 78% CACS>100 and 15% CACS>...
Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Alexander R. van Rosendael, Miguel Cainzos-Achirica, Mouaz H. Al-Mallah Tags: Editorial Source Type: research

A “light based biopsy” for high-risk atherosclerotic plaque
Atherosclerosis is a dynamic systemic disease leading to progressive arterial plaque accumulation that is associated with a proportional increase in the risk of major adverse clinical events (MACE). Progression is non-linear and related to cycles of plaque destabilisation, erosion or rupture, which only occasionally result in MACE and mostly are followed by healing1. In clinical practice, healed plaque can be detected using optical coherence tomography (OCT). OCT utilises near infrared light for intra-coronary imaging and has a high resolution (10-20 μm), which is 10-20 times better than intravascular ultrasound (IVUS) ...
Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Kamran Majeed, Graham S. Hillis, Carl J. Schultz Source Type: research

Familial hypercholesterolemia: a single-nucleotide variant (SNV) in mosaic at the low density lipoprotein receptor (LDLR)
The objective of this article was the molecular characterization of a patient with hypercholesterolemia. (Source: Atherosclerosis)
Source: Atherosclerosis - August 27, 2020 Category: Cardiology Authors: Sonia Rodr íguez-Nóvoa, Carmen Rodríguez-Jiménez, Concepción Alonso, Lara Rodriguez-Laguna, Gema Gordo, Victor Martinez-Glez, Iluminada García Polo Source Type: research

Identification and visualization of oxidized lipids in atherosclerotic plaques by microscopic imaging mass spectrometry-based metabolomics
Dysregulated lipid metabolism has emerged as one of the major risk factors of atherosclerosis. Presently, there is a consensus that oxidized LDL (oxLDL) promotes development of atherosclerosis and downstream chronic inflammatory responses. Due to the dynamic metabolic disposition of lipoprotein, conventional approach to purify bioactive lipids for subsequent comprehensive analysis has proven to be inadequate for elucidation of the oxidized lipids species accountable for pathophysiology of atherosclerotic lesions. (Source: Atherosclerosis)
Source: Atherosclerosis - August 27, 2020 Category: Cardiology Authors: Lianhua Shen, Takushi Yamamoto, Xian Wen Tan, Koretsugu Ogata, Eiji Ando, Eiichi Ozeki, Eiji Matsuura Source Type: research

Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE –/– mice
Atherosclerosis is mainly caused by stress in arterial microenvironments, which results in the formation of stress granules as a consequence of the stress response. As the core protein of stress granules, GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) is known to play pivotal roles in tumour initiation, viral infection and Alzheimer ’s disease, but the role of G3BP2 in atherosclerosis development is poorly understood. Previous studies have shown that vaccination with epitopes from self-antigens could reduce atherosclerotic lesions. (Source: Atherosclerosis)
Source: Atherosclerosis - August 26, 2020 Category: Cardiology Authors: Tianhan Li, Maharani Safitri, Kang Zhang, Yi Wang, Lu Huang, Yuan Zhu, Richard Daniel, Ling Juan Wu, Juhui Qiu, Guixue Wang Source Type: research

Association of human immunodeficiency virus and hepatitis C virus infection with long-term outcomes post-ST segment elevation myocardial infarction in a disadvantaged urban community
HIV and HCV have been linked to an increased risk of cardiovascular disease (CVD). Their impact on long-term outcomes following ST-segment myocardial infarction (STEMI) has not been previously studied. (Source: Atherosclerosis)
Source: Atherosclerosis - August 26, 2020 Category: Cardiology Authors: Sanyog G. Shitole, Mark H. Kuniholm, David B. Hanna, Thomas Boucher, Angel Y. Peng, Cecilia Berardi, Tina Shah, Anna E. Bortnick, Panagiota Christia, James Scheuer, Jorge R. Kizer Source Type: research

Hyperuricemia precedes non-alcoholic fatty liver disease with abdominal obesity moderating this unidirectional relationship: Three longitudinal analyses
This study aimed to explore whether there exists a bidirectional or temporal relationship between them. (Source: Atherosclerosis)
Source: Atherosclerosis - August 26, 2020 Category: Cardiology Authors: Zhimin Ma, Jingbo Zhang, Xiaoping Kang, Chaonan Xu, Ce Sun, Lixin Tao, Deqiang Zheng, Yumei Han, Qiang Li, Xiuhua Guo, Xinghua Yang Source Type: research

New horizons for mortality risk stratification in PAD: Are targeted multiplex proteomics the next step?
Both morbidity and mortality of peripheral artery disease (PAD) remain unsatisfactory high with 113 all-cause death events per 1000 patient years, as depicted by a meta-analysis with data of the last two decades (1). Recent therapy improvements of traditional risk factors for PAD patients, like antiplatelet/anticoagulation therapy with Rivaroxaban (2) or further LDL-C lowering by PCSK9 inhibition (3) therapy might improve these numbers in meta-analyses in the next years. However, since traditional risk factors do not solely explain the high morbidity and mortality risk of PAD patients, as a model for traditional risk facto...
Source: Atherosclerosis - August 25, 2020 Category: Cardiology Authors: Bernhard Zierfuss, Christoph Neumayer, Gerit-Holger Schernthaner Tags: Editorial Source Type: research

Association of left ventricular strain and E/e ’ ratio with carotid wall layers
In an interesting report published in July, 2020, Nakanishi et al. showed that greater carotid intima-media thickness (cIMT) was associated with abnormal left ventricular (LV) global longitudinal strain (GLS) and E/e ’ ratio values in a community-based population [1]. As stated by the authors, the mechanisms underlying these associations are still uncertain. It is noteworthy that cIMT does not discriminate wall thickening due to increases in intima thickness (cIT), a more proper marker of atherosclerosis, or m edia thickness (cMT), a layer mostly composed of vascular smooth muscle cells [2,3]. (Source: Atherosclerosis)
Source: Atherosclerosis - August 24, 2020 Category: Cardiology Authors: Lu ís F.R.S. Carvalho-Romano, Rafael P. Bonafé, Layde R. Paim, Edmilson R. Marques, Camila F.L. Vegian, José A. Pio-Magalhães, Daniel S.S. Mello, Roberto Schreiber, Andrei C. Sposito, José R. Matos-Souza, Wilson Nadruz Tags: Correspondence Source Type: research

Analysis of Interaction Between Porphyromonas gingivalis and Endothelial Cells In Vitro.
Abstract Chronic periodontitis is the most common periodontitis observed in adults. Recently, its association with systemic diseases such as ischemic heart-brain disease and diabetes has been pointed out. Porphyromonas gingivalis, a major causative bacterium of chronic periodontitis, has properties of adhering to blood vessels and inducing inflammation, and those properties are involved in the induction of vascular inflammation and promotion of atherosclerosis. Therefore, analysis of the interaction of P. gingivalis with vascular endothelial cells will contribute to an understanding of the link between periodontit...
Source: Atherosclerosis - August 22, 2020 Category: Cardiology Authors: Matsushita K Tags: Methods Mol Biol Source Type: research

Genetics of adrenergic signaling drives coronary artery calcification
Cardiovascular diseases hold primacy as a leading cause of morbidity and mortality worldwide, making especially engaging the research towards the identification of the potential underlying mechanisms as well as the prognostic factors and predictors of the disease. Despite being extensively studied, atherogenesis and its progression remain among the most fascinating phenomena, with various interrogatives still open. The atherosclerotic process is multifactorial, involves different cells, and generates new cellular phenotypes. (Source: Atherosclerosis)
Source: Atherosclerosis - August 17, 2020 Category: Cardiology Authors: Jessica Gambardella, Xujun Wang, Pasquale Mone, Wafiq Khondkar, Gaetano Santulli Tags: Editorial Source Type: research

Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is the rate-limiting enzyme catalyzing the final step of triglyceride (TG) synthesis by esterifying a diglyceride with a fatty acid. We have previously shown that apolipoprotein E-knockout (ApoE-/-) mice lacking Dgat1 have reduced intestinal cholesterol absorption and potentiated macrophage cholesterol efflux, and consequently, exhibit attenuated atherogenesis. However, hematopoietic Dgat1 deficiency lacked beneficial effects on atherosclerosis. Due to our recent results on the critical role of intestinal Dgat1 in murine cholesterol homeostasis, we delineated whether intest...
Source: Atherosclerosis - August 9, 2020 Category: Cardiology Authors: Nemanja Vujic, Melanie Korbelius, Vinay Sachdev, Silvia Rainer, Andreas Zimmer, Anton Huber, Branislav Radovic, Dagmar Kratky Source Type: research

Electronic health records to facilitate continuous detection of familial hypercholesterolemia
Familial hypercholesterolemia (FH) is an inherited disorder associated with increased risk of coronary heart disease as a result of high LDL-cholesterol (LDL-C). The clinical diagnosis can be made with the Dutch Lipid Clinic Network criteria (DLCN criteria). FH is an underdiagnosed disorder, possibly due to false negative LDL-C interpretation during lipid lowering therapy (LLT). We hypothesized that automated health record-based integration of data can provide a signal to facilitate identification of FH patients. (Source: Atherosclerosis)
Source: Atherosclerosis - August 8, 2020 Category: Cardiology Authors: Shari Pepplinkhuizen, Shirin Ibrahim, Rutger Vink, Bas Groot, Erik S.G. Stroes, Willem A. Bax, Jan H. Cornel Source Type: research