Abnormal expression of long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) participates in the pathological mechanism of atherosclerosis by regulating miR-224-3p
In conclusion, RMST has the potential to be a diagnostic marker for AS. RMST-knockdown contributes to the enhancement of cell viability and the inhibition of inflammatory response, which may provide new insights into the conquest of AS.PMID:35067166 | DOI:10.1080/21655979.2021.2023995 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Tao Zhang Cuina Feng Xiang Zhang Bin Sun Ying Bian Source Type: research

Erratum to 'Novel glycoproteins identify preclinical atherosclerosis among women with previous preeclampsia regardless of type 1 diabetes status' [Nutrition, Metabolism & amp; Cardiovascular Diseases 31 (2021) 3407-3414]
Nutr Metab Cardiovasc Dis. 2022 Jan 20:S0939-4753(21)00557-3. doi: 10.1016/j.numecd.2021.11.016. Online ahead of print.NO ABSTRACTPMID:35067444 | DOI:10.1016/j.numecd.2021.11.016 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Antonio J Amor Irene Vinagre Maite Valverde N úria Alonso-Carril Xavier Urquizu Eva Meler Eva L ópez Marga Gim énez Laura Codina Ignacio Conget Maria J Barahona Ver ónica Perea Source Type: research

Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population
In this study, the plasma exosomal circRNA expression profiles of three IS patients and three healthy controls were analyzed using circRNA sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and circRNA-miRNA-mRNA regulatory network analysis were performed for the aberrantly expressed genes. Protein-protein interaction (PPI) networks and molecular complex detection algorithms (MCODEs) were analyzed by STRING and Cystoscope for functional annotation and construction, respectively. RNA-Seq analysis revealed that a total of 3540 circRNAs were aberrantly expressed in ex...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Bingyi Xu Xianli Huang Yan Yan Zhi Zhao Jialei Yang Lulu Zhu Yibing Yang Baoyun Liang Lian Gu Li Su Source Type: research

Tuberous xanthomas in a pediatric patient: a clue to the early diagnosis of a severe and infrequent disease
We present the case of a patient who started at two years with tuberous xanthomas, which were the diagnostic clue to identify the underlying homozygous familial hypercholesterolaemia.PMID:35068128 | DOI:10.5546/aap.2022.e34 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Loreto Heredia Javier Arellano Yamile Corredoira Source Type: research

Risk for Subsequent SARS-CoV-2 Infection and Severe COVID-19 Among Community-Dwellers With Pre-Existing Cervicocephalic Atherosclerosis: A Population-Based Study
CONCLUSIONS: Pre-existing cervicocephalic atherosclerosis does not increase the risk of acquiring SARS-CoV-2 infection nor the severity of COVID-19 among seropositive individuals.PMID:35068245 | DOI:10.1177/21501319211070685 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Oscar H Del Brutto Robertino M Mera Victor J Del Brutto Bettsy Y Recalde Denisse A Rumbea Aldo F Costa Mark J Sedler Source Type: research

Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath
Expert Opin Ther Targets. 2022 Jan 24. doi: 10.1080/14728222.2022.2031975. Online ahead of print.ABSTRACTINTRODUCTION: : In COVID-19 pneumonia, there is massive increase in fatty acid levels and lipid mediators with a predominance of cyclooxygenase metabolites, notably TxB2 ≫ PGE2> PGD2 in the lungs, and 11-dehydro-TxB2, a TxA2 metabolite, in the systemic circulation. While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of the DP2 (formerly known as the CRTh2) receptors for PGD2. Anecdotal experience of using ramatroban, a dual receptor antagonist of the TxA2/TP and PGD2/DP2 r...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Kate C Chiang John G Rizk Deanna J Nelson Lakshmanan Krishnamurti Selvakumar Subbian John D Imig Imran Khan Srinivasa T Reddy Ajay Gupta Source Type: research

Characterization of Blood Outgrowth Endothelial Cells (BOEC) from Porcine Peripheral Blood
J Vis Exp. 2022 Jan 6;(179). doi: 10.3791/63285.ABSTRACTThe endothelium is a dynamic integrated structure that plays an important role in many physiological functions such as angiogenesis, hemostasis, inflammation, and homeostasis. The endothelium also plays an important role in pathophysiologies such as atherosclerosis, hypertension, and diabetes. Endothelial cells form the inner lining of blood and lymphatic vessels and display heterogeneity in structure and function. Various groups have evaluated the functionality of endothelial cells derived from human peripheral blood with a focus on endothelial progenitor cells deriv...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Akankshya Shradhanjali Susheil Uthamaraj Dan Dragomir-Daescu Rajiv Gulati Gurpreet S Sandhu Brandon J Tefft Source Type: research

Bone Marrow Origin of Coronary Artery Diseases: The Impact of the Local Renin-Angiotensin System
In this study, we review the relationship between local bone marrow and local cardiac RAS and their impacts on atherosclerosis.PMID:35068878 | PMC:PMC8743471 | DOI:10.6515/ACS.202201_38(1).20210830A (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Ugur Nadir Karakulak Elifcan Aladag Ibrahim Celalettin Haznedaro ğlu Source Type: research

Vertebrobasilar Junction Angle Over 90: A Potential Imaging Marker Associated With Vertebrobasilar Atherosclerosis
Front Neurosci. 2022 Jan 5;15:789852. doi: 10.3389/fnins.2021.789852. eCollection 2021.ABSTRACTObjective: Whether the cerebral vascular variations play an important role in the progression of intracranial atherosclerosis is yet largely unclear. We aimed to investigate the relationship between the magnitude of the vertebrobasilar junction (VBJ) angle and the imaging features of vertebrobasilar artery atherosclerosis. Methods: Adult patients with acute ischemic stroke or transient ischemic attack undergoing a 3.0-tesla vessel wall magnetic resonance imaging (VW-MRI) scanning were consecutively included. Imaging features of v...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Jia Li Wen-Jie Yang Lu Zheng Heng Du Winnie Chiu-Wing Chu Thomas Wai-Hong Leung Xiang-Yan Chen Source Type: research

Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway Axis
CONCLUSIONS: The IL18/IL18R1/HIF1A axis is expected to be an therapeutic target for cardiovascular protection after SARS-CoV-2 infection. MEK inhibitors may be an choice for cardiovascular protection after SARS-COV-2 infection.PMID:35069552 | PMC:PMC8766743 | DOI:10.3389/fimmu.2021.780804 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Liwei Zhang Mingxing Li Zhiwei Wang Peng Sun Shunbo Wei Cong Zhang Haoliang Wu Hualong Bai Source Type: research

Caffeic Acid Prevents Vascular Oxidative Stress and Atherosclerosis against Atherosclerogenic Diet in Rats
Evid Based Complement Alternat Med. 2022 Jan 13;2022:8913926. doi: 10.1155/2022/8913926. eCollection 2022.ABSTRACTDiet and lifestyle play a crucial role in the progress of some cardiovascular disorders (CVDs). Rising interest in natural products and their pharmacological investigations witnessed therapeutic potential against CVDs. Caffeic acid (CA) is an organic composite hydroxycinnamic acid derivative classified among phenolics. It is a secondary metabolite biosynthesized in all plant species in the form of ester conjugates. The reported pharmacological activities of CA are neuroprotective, cardioprotective, hypoglycemic...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Ying Wang Gurpreet Kaur Manish Kumar Ajay Singh Kushwah Atul Kabra Ritu Kainth Source Type: research

Cardiovascular comorbidities in psoriasis (Review)
Exp Ther Med. 2022 Feb;23(2):152. doi: 10.3892/etm.2021.11075. Epub 2021 Dec 17.ABSTRACTLong considered a skin-limited condition, psoriasis is currently defined as a chronic, immune-mediated inflammatory disease, presenting, besides the skin changes, important systemic manifestations, the most common being: psoriatic arthritis, cardiovascular disease, metabolic syndrome, diabetes, inflammatory bowel disease and nonalcoholic steatohepatitis. It is a disease with a strong psycho-emotional and social impact, both through skin changes such as pruritic, scaly erythematous plaques, and through the association of comorbidities th...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Daciana Elena Branisteanu Alin Codrut Nicolescu Daniel Constantin Branisteanu Catalina Ioana Branisteanu Andreea Corina Dragoi Camelia Margareta Bogdanici Mihaela Paula Toader Andreea Lorena Tucaliuc Andreea Dimitriu Doru Daogaru Ruxandra Angela Pirvulesc Source Type: research

Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated-M1 Macrophage Polarization-Dependent Vascular Smooth Muscle Cell Phenotypic Conversion
CONCLUSIONS: AGEs induced activation of RAGE/TLR4/FOXC2 signaling, which featured macrophage with Dll4 high expression during M1 polarization. These macrophages promoted contractile-synthetic phenotypic conversion of VSMCs through the Dll4/Notch pathway after direct cell-to-cell contacts.PMID:35069982 | PMC:PMC8776434 | DOI:10.1155/2022/9763377 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Yujie Xing Shuo Pan Ling Zhu Qianwei Cui Zhiguo Tang Zhongwei Liu Fuqiang Liu Source Type: research

Gene Differential Expression and Interaction Networks Illustrate the Biomarkers and Molecular Mechanisms of Atherosclerotic Cerebral Infarction
In conclusion, this study suggested that FCGR3A and MAPK pathways were connected with ACI.PMID:35070236 | PMC:PMC8769835 | DOI:10.1155/2022/3912697 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Benzhuo Zhang Wei Huang Mingquan Yi Chunxu Xing Source Type: research

Maternal resveratrol supplementation ameliorates bisphenol A-induced atherosclerotic lesions formation in adult offspring ApoE < sup > -/- < /sup > mice
3 Biotech. 2022 Jan;12(1):36. doi: 10.1007/s13205-021-03078-y. Epub 2022 Jan 4.ABSTRACTCurrent evidence suggests that intrauterine bisphenol A (BPA) exposure increases the risk of developing cardiovascular diseases in later stages of life. The beneficial effect of resveratrol (Rsv) on developmental programming of atherosclerosis lesions formation in offspring is seldom reported. Hence, we sought to study the effect of maternal Rsv in ameliorating perinatal BPA exposure-induced atherosclerosis lesions formation in adult offspring using the apolipoprotein E-deficient (ApoE-/-) mice model. The pregnant ApoE-/- mice were alloc...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Srinivasa Rao Sirasanagandla Isehaq Al-Huseini Mohamed Al Mushaiqri Nadia Al-Abri Fatma Al-Ghafri Source Type: research

A novel animal model for vulnerable atherosclerotic plaque: dehydrated ethanol lavage in the carotid artery of rabbits fed a Western diet
In this study, we attempted to develop a novel animal model for vulnerable atherosclerotic plaques using dehydrated ethanol lavage in rabbits fed a Western diet (WD).METHODS: A total of 30 New Zealand White (NZW) rabbits were randomized to 5 groups, including a control group with or without WD, a balloon injury with WD group, and an ethanol injury with or without WD group. Operations were conducted using the right common carotid artery as the target vessel. All animals were followed up for 3 months unless a vascular event occurred. Blood samples and carotid artery specimens were ultimately collected for analysis of atherog...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Ruochi Zhao Hongyan Liu Shangshi Zhang Qi Lu Xiaohong Fei Honglin Zhou Junsong Liu Honghua Ye Xiaomin Chen Hanbin Cui Source Type: research

Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
CONCLUSIONS: We confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD.PMID:35070816 | PMC:PMC8749067 | DOI:10.21037/tau-21-899 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Yuanyuan Zhao Yang Fan Mengru Wang Chenguang Yu Mengchen Zhou Dan Jiang Dunfeng Du Shanshan Chen Xin Tu Source Type: research

Understanding of Pathophysiology and Optimal Treatment for Anterior Circulation Large Vessel Occlusion beyond 24 h from Onset of Stroke
We report three cases in which endovascular treatment (EVT) was performed for anterior circulation large vessel occlusion (LVO) beyond 24 h from the onset of stroke. Case 1 experienced left hemispatial neglect and gait disorder due to right internal cerebral artery (ICA) occlusion and underlying atherosclerosis. After percutaneous transluminal angioplasty (PTA), revascularization with mild stenosis was achieved. Case 2 complained of reduced activity, motor aphasia, and right-sided hemiparesis due to left middle cerebral artery occlusion. After thrombectomy using a retrieval stent, revascularization with M1 stenosis and dis...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Takashi Mizowaki Atsushi Uyama Atsushi Fujita Jun Imura Hiroyasu Shose Hirotomo Tanaka Yoshiyuki Takaishi Takeshi Kondoh Source Type: research

Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis
In this study, 59 genes associated with ferroptosis were ultimately identified in atherosclerosis in the intima. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed for functional annotation. Through the construction of protein-protein interaction (PPI) network, five hub genes (TP53, MAPK1, STAT3, HMOX1, and PTGS2) were then validated histologically. The competing endogenous RNA (ceRNA) network of hub genes was ultimately constructed to explore the regulatory mechanism between lncRNAs, miRNAs, and hub genes. The findings provide more insights into the ferroptosis...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Tucheng Huang Kangjie Wang Yuewei Li Yanchen Ye Yangxin Chen Jingfeng Wang Chen Yao Source Type: research

Exercise and Carotid Properties in the Young-The KiGGS-2 Study
Conclusions: Increased levels of exercise are associated with a better cardiovascular risk profile in young individuals, but not with cS and cIMT. Our study confirms previous recommendations on exercise in this age group without demonstrating a clear benefit on surrogate markers of vascular health.PMID:35071349 | PMC:PMC8766972 | DOI:10.3389/fcvm.2021.767025 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Karsten K önigstein Julia Charlotte B üschges Giselle Sarganas Susanne Krug Hannelore Neuhauser Arno Schmidt-Trucks äss Source Type: research

Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity
Front Cardiovasc Med. 2022 Jan 7;8:785250. doi: 10.3389/fcvm.2021.785250. eCollection 2021.ABSTRACTBackground: Extracellular vesicles (EV) concentration is generally increased in patients with cardiovascular diseases, although the protective role of EVs in atherosclerosis has been reported. Among the specific cargo of EVs, miRNAs contribute to different stages of atherosclerosis. Aim of the present report has been to investigate, in individuals with obesity, the interplay among EVs derived from cells relevant for the atherosclerotic process (i.e., platelets, endothelium, monocytes/macrophages, and neutrophils), their miRNA...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Chiara Macchi Maria Francesca Greco Chiara Favero Laura Dioni Laura Cantone Mirjam Hoxha Luisella Vigna Giulia Solazzo Alberto Corsini Maciej Banach Angela C Pesatori Valentina Bollati Massimiliano Ruscica Source Type: research

Endocan: A Key Player of Cardiovascular Disease
Front Cardiovasc Med. 2022 Jan 5;8:798699. doi: 10.3389/fcvm.2021.798699. eCollection 2021.ABSTRACTEndothelial dysfunction is considered to be an early change in atherosclerosis. Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Inflammatory factors such as IL-1β and TNF-α can up regulate the expression of endocan and then affect the expression of cell adhesion molecules, such as ICAM-1 and VCAM-1, which play an important role in promoting leukocyte migration and inflammatory response. Elevated plasma levels of endocan may reflect endothe...
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Jinzhi Chen Liping Jiang Xiao-Hua Yu Mi Hu Yang-Kai Zhang Xin Liu Pingping He Xinping Ouyang Source Type: research

PDGF-BB promotes vascular smooth muscle cell migration by enhancing Pim-1 expression via inhibiting miR-214
CONCLUSIONS: Our data suggested that the PDGF/miR-214/Pim-1 axis could be a potential target for coronary atherosclerotic heart disease.PMID:35071422 | PMC:PMC8743727 | DOI:10.21037/atm-21-5638 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Jinshan Zhou Lifang Shao Jianghao Yu Junchao Huang Qiang Feng Source Type: research

Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study
CONCLUSIONS AND RELEVANCE: In this study, risk of dementia significantly increased after ischemic stroke, independent of vascular risk factors. Results suggest a dose-response association of stroke severity and recurrence with risk of dementia.PMID:35072712 | DOI:10.1001/jamaneurol.2021.5080 (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Silvia Koton James Russell Pike Michelle Johansen David S Knopman Kamakshi Lakshminarayan Thomas Mosley Shalom Patole Wayne D Rosamond Andrea L C Schneider A Richey Sharrett Lisa Wruck Josef Coresh Rebecca F Gottesman Source Type: research

Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry
Patients with peripheral artery disease (PAD) represent a high risk group, and have an increased risk of cardiovascular events and worse cardiovascular outcomes. Our aim was to study the impact of PAD among patients undergoing percutaneous coronary intervention (PCI) with a newer-generation thin-strut DES. (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Ofer Kobo, Majdi Saada, Peep Laanmets, Dimitar Karageorgiev, Helen Routledge, Jim Crowley, Pascual Baello, Javier Balague Requena, Fabrizio Span ó, Luis Perez, Jesus Maria Jimenez Mazuecos, Mamas A. Mamas, Ariel Roguin Source Type: research

Apolipoproteins and lipoprotein(a) as factors modulating fibrin clot properties in patients with severe aortic stenosis
Large amounts of clot-bound lipoproteins were reported in proteomic analysis but their impact on fibrin clot properties is unknown. We investigated a contribution of lipid profile and apolipoproteins (apo) to the prothrombotic plasma fibrin clot phenotype in patients with aortic stenosis (AS). (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Jakub Siudut, Joanna Natorska, Ewa Wypasek, Łukasz Wiewiórka, Elżbieta Ostrowska-Kaim, Sylwia Wiśniowska-Śmiałek, Krzysztof Plens, Piotr Musialek, Jacek Legutko, Anetta Undas Source Type: research

Cholesterol uptake capacity: A new measure of high-density lipoprotein functionality as a predictor of subsequent revascularization in patients undergoing percutaneous coronary intervention
High-density lipoprotein (HDL) functionality is an important determinant of coronary artery disease (CAD) development. We recently developed cholesterol-uptake capacity (CUC), a rapid cell-free assay system that directly evaluates the capacity of HDL to accept additional cholesterol. We aimed to evaluate the association between CUC and revascularization in patients who have undergone percutaneous coronary intervention (PCI). (Source: Atherosclerosis)
Source: Atherosclerosis - January 24, 2022 Category: Cardiology Authors: Daichi Fujimoto, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Manabu Nagao, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Shunsuke Kakizaki, Koichi Nakamura, Amane Harada, Katsuhiro Murakami, Takuya Iino, Ryuji Toh, Ken-ichi Hirat Source Type: research

Increased admission serum total bile acids can be associated with decreased 3-month mortality in patients with acute ischemic stroke
Lipids Health Dis. 2022 Jan 22;21(1):15. doi: 10.1186/s12944-021-01620-8.ABSTRACTBACKGROUND: Bile acids (BAs) not only play an important role in lipid metabolism and atherosclerosis but also have antiapoptotic and neuroprotective effects. However, few studies have focused on the relationship of the total bile acid (TBA) levels with the severity and prognosis of acute ischemic stroke (AIS).OBJECTIVES: The aim of this study was to investigate the potential associations of the fasting serum TBA levels on admission with the stroke severity, in-hospital complication incidence and 3 -month all-cause mortality in patients with AI...
Source: Atherosclerosis - January 23, 2022 Category: Cardiology Authors: Lingling Huang Ge Xu Rong Zhang Yadong Wang Jiahui Ji Fengdan Long Yaming Sun Source Type: research

Roles and mechanisms of puerarin on cardiovascular disease :A review
Biomed Pharmacother. 2022 Jan 20;147:112655. doi: 10.1016/j.biopha.2022.112655. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are now the leading cause of mortality and morbidity worldwide,resulting in a large global economic burden. Recently, complementary and alternative medicine, such as traditional Chinese medicine (TCM) have received great attention. Puerarin (Pue) is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi (also named "Ge gen" in China), and is a versatile TCM herb used for the treatment of fever, diarrhea, diabetes mellitus CVDs and cerebrovascular diseases. ...
Source: Atherosclerosis - January 23, 2022 Category: Cardiology Authors: Zhilin Jiang Xiangning Cui Peirong Qu Chang Shang Mi Xiang Jie Wang Source Type: research

Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium
This article is protected by copyright. All rights reserved.PMID:35066972 | DOI:10.1002/cbin.11768 (Source: Atherosclerosis)
Source: Atherosclerosis - January 23, 2022 Category: Cardiology Authors: George N Koukoulis Maria Filiponi Sofia Gougoura Christina Befani Panagiotis Liakos Αlexandra Bargiota Source Type: research

Carotid plaque is strongly associated with coronary artery calcium and predicts incident coronary heart disease in a population-based cohort
Coronary artery calcium (CAC) and carotid plaque are markers of atherosclerosis and predict future coronary heart disease (CHD) events. The aim of this study was to investigate associations between CAC and carotid plaque in asymptomatic individuals, also in relation to predicted CHD-risk and incident events. A secondary aim was to compare predictive value between CAC, carotid plaque, and total carotid plaque area (TPA) as predictors for future CHD-events. (Source: Atherosclerosis)
Source: Atherosclerosis - January 23, 2022 Category: Cardiology Authors: Elias Freyr Gudmundsson, Gudlaug Bj örnsdottir, Sigurdur Sigurdsson, Karl Andersen, Bolli Thorsson, Thor Aspelund, Vilmundur Gudnason Source Type: research

Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
Biomed Pharmacother. 2022 Feb;146:112579. doi: 10.1016/j.biopha.2021.112579. Epub 2021 Dec 30.ABSTRACTLow grade inflammation is associated with the progression of atherosclerosis. Patients with type 2 diabetes (T2D) have altered cholesterol levels, which are targeted by free radicals to promote lipid peroxidation. Elevated levels of monocyte-associated cytokines such as interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and tumor necrosis factor-alpha (TNF-α), subsequently drive endothelial tissue injury. In fact, the levels of...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Siphamandla R Ngcobo Bongani B Nkambule Tawanda M Nyambuya Kabelo Mokgalaboni Aviwe Ntsethe Vuyolwethu Mxinwa Khanyisani Ziqubu Yonela Ntamo Thembeka A Nyawo Phiwayinkosi V Dludla Source Type: research

Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCbeta(1) signaling pathway in diabetic atherosclerosis
CONCLUSIONS: Diabetes mellitus aggravates chronic inflammation, and promotes atherosclerotic plaques in conjunction with hyperlipidemia, which at least in part through inducing the immune maturation of DCs, and its possible mechanism of action is through the RAGE-TLR4-pPKCβ1 signaling pathway.PMID:35062863 | DOI:10.1186/s10020-022-00431-6 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Liding Zhao Ya Li Tian Xu Qingbo Lv Xukun Bi Xianglan Liu Guosheng Fu Yunzeng Zou Junbo Ge Zhaoyang Chen Wenbin Zhang Source Type: research

ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis
J Pharmacol Sci. 2022 Feb;148(2):197-203. doi: 10.1016/j.jphs.2021.11.005. Epub 2021 Dec 1.ABSTRACTPrevention of atherosclerosis is important because it is a risk factor for cardiovascular diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and triglycerides in peripheral cells. ATP-binding cassette protein A1 (ABCA1) and G1 (ABCG1) are important in eliminating excess cholesterol from cells including macrophages and forming high-density lipoprotein, which contributes to the prevention and regression of atherosclerosis. Enhanced cholesterol efflux activities of ABCA1 and ABCG1 are expected...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Michinori Matsuo Source Type: research

The effects of selenium administration on carotid intima-media thickness and metabolic status in diabetic hemodialysis patients: A randomized, double-blind, placebo-controlled trial
This study was designed to assess the effects of selenium supplementation on CIMT and metabolic profiles of in diabetic hemodialysis (HD) patients.MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was performed on 60 diabetic HD patients. Subjects were randomly assigned to receive selenium supplements or placebo (starch). Individuals in the selenium group (n = 30) received 200 μg selenium per day in the placebo group (n = 30) received for 24 weeks. Fasting blood samples were taken at the study baseline and after 24 weeks of intervention.RESULTS: Following the administration of selenium suppl...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Marzieh Salimian Alireza Soleimani Fereshteh Bahmani Seyed Mohammad Hossein Tabatabaei Zatollah Asemi Hamid Reza Talari Source Type: research

Cardiometabolic Diseases and Female Sexual Dysfunction: Animal Studies
CONCLUSION: Preclinical evidence exists showing cardiometabolic diseases alter the structure and function of female genital tissues. However, similar to clinical studies, there are few studies to draw from, particularly in models of type 2 diabetes, obesity and metabolic syndrome. More studies are required using optimized animal models and methodology to confirm the mechanisms underlying cardiometabolic disease-induced FSD. Angulo J, Hannan JL. Cardiometabolic Diseases and Female Sexual Dysfunction: Animal Studies. J Sex Med 2021;XX:XXX-XXX.PMID:35063393 | DOI:10.1016/j.jsxm.2021.12.009 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Javier Angulo Johanna L Hannan Source Type: research

Association of Pericardial Fat with Cardiac Structure, Function and Mechanics: the Multi-Ethnic Study of Atherosclerosis
J Am Soc Echocardiogr. 2022 Jan 18:S0894-7317(22)00007-4. doi: 10.1016/j.echo.2022.01.005. Online ahead of print.ABSTRACTBACKGROUND: Pericardial fat has been associated with adverse cardiovascular outcomes through adiposity-associated inflammation and insulin resistance, which in turn are linked to cardiac dysfunction. We sought to evaluate the association between pericardial fat volume with cardiac structure and function in adults without baseline cardiovascular disease.METHODS: We analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA). Linear regression was used to examine the association between pericardial...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Jeff Min Mary E Putt Wei Yang Alain Bertoni Jingzhong Ding Joao A C Lima Matthew A Allison R Graham Barr Nadine Al-Naamani Ravi B Patel Lauren Beussink-Nelson Steven Kawut Sanjiv J Shah Benjamin H Freed Source Type: research

Evidence base for the management of women with non-ST elevation acute coronary syndrome
Heart. 2022 Jan 21:heartjnl-2021-320533. doi: 10.1136/heartjnl-2021-320533. Online ahead of print.ABSTRACTAccording to the Global Burden of Disease study, in 2019, there were an estimated 275.2 million cases of cardiovascular disease (CVD) in women worldwide. Although there was a decrease in the global age-standardised prevalence of CVD in women between 1990 and 2010 (-5.8%), there has been a slight increase (1.0%) since 2010. There were an estimated 6.10 million deaths from CVD in women in 1990, rising to 8.94 million in 2019. Hospital admissions of young women with acute myocardial infarction (AMI) steadily increased fro...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: James Jackson Mohammad Alkhalil Hanna Ratcovich Chris Wilkinson Roxana Mehran Vijay Kunadian Source Type: research

Premature coronary artery disease in patients with immune-mediated inflammatory disease: a population-based study
CONCLUSIONS: Primary Sjogren's syndrome, SLE, SSc and SV are associated with an increased risk of premature CAD. Our findings will support essential efforts to improve awareness of IMID impacting young adults.PMID:35064093 | DOI:10.1136/rmdopen-2021-001993 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Edward Chia-Cheng Lai Ya-Chun Huang Tzu-Chi Liao Meng-Yu Weng Source Type: research

Exosomes in cardiovascular diseases: a blessing or a sin for the mankind
Mol Cell Biochem. 2022 Jan 22. doi: 10.1007/s11010-021-04328-6. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) comprises disorders of blood vessels and heart. Multiple cells in the heart suggests that hetero-cellular communication, which is an important aspect in heart functioning and there is a need to elucidate the way in which this inter-cellular communication occurs. Now a days, exosomal research has gained much attention. Exosomes, nano-shuttles, are EVs with diameters ranging from 40 to 160 nm (average 100 nm), secreted by body cells. These vesicles act as cell-to-cell communicators and are carriers of ...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Shruti Sharma Ujjawal Sharma Source Type: research

A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux
J Physiol Biochem. 2022 Jan 22. doi: 10.1007/s13105-021-00870-5. Online ahead of print.ABSTRACTAtherosclerosis (AS) is a chronic inflammatory disease characterized by abnormal lipid metabolism. Foam cell formation is also known as an early event of AS. Cholesterol efflux is a process whereby cholesterol is excreted from foam cells through transporters, which serves as one of the effective regulatory mechanisms to prevent AS. Autophagy is a biodegradable mechanism, and lipophagy is a special form of autophagy that selectively degrades lipids. Cholesterol efflux is regulated by several mechanisms. Moreover, numerous studies ...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Haipeng Guo Dongmei Wei Rui Liu Chao Zhang Song Jiang Weijia Wang Hongzhe Hu Lijuan Shen Xiaofei Liang Source Type: research

Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF- κB signaling pathway in vivo and in vitro
J Nat Med. 2022 Jan 22. doi: 10.1007/s11418-021-01594-y. Online ahead of print.ABSTRACTCorilagin, a natural polyphenol compound isolated from Phyllanthus urinaria L., exerts various pharmacological effects, such as antihyperglycemic, antitumor, and antioxidative stress properties, but the mechanisms underlying the antiatherosclerotic effects of corilagin have not been entirely elucidated. In the present study, we investigated the antiatherosclerotic effects of corilagin using a high-fat diet (HFD)-induced atherosclerotic rabbit model and ox-LDL-induced vascular smooth muscle cells (VSMCs) and explored the underlying molecu...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Bo He Deyun Chen Xiaochao Zhang Renhua Yang Yuan Yang Peng Chen Zhiqiang Shen Source Type: research

Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: National Health and Nutrition Examination Surveys (NHANES): A cross-sectional study
CONCLUSION: In conclusion, this study found a positive association between urinary PAHs and the prevalence of various CVDs among the US population.PMID:35065070 | DOI:10.1016/j.envres.2022.112775 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Manthar Ali Mallah Li Changxing Mukhtiar Ali Mallah Muhammad Naveed Yang Liu Sobia Noreen He Xi Wei Wang Feifei Feng Qiao Zhang Source Type: research

Therapeutic role of eicosapentaenoic and arachidonic acid in benzo(a) pyrene-induced toxicity in HUVEC endothelial cells
Life Sci. 2022 Jan 20;293:120345. doi: 10.1016/j.lfs.2022.120345. Online ahead of print.ABSTRACTEndothelial cells are characterized by intense metabolic activity and control of homeostasis. Exposure to benzo(a)pyrene (BaP) plays an important role in the etiology of atherosclerosis. The study aimed to determine the effect of arachidonic (ARA), and eicosapentaenoic acid (EPA) on pro-inflammatory gene and protein levels in human umbilical vein endothelial cells (HUVEC) exposed to BaP. Cyclooxygenase-2 (COX-2), aryl hydrocarbon receptor (AHR), and glutathione S transferase Mu1 (GSTM1) proteins expression were analyzed by Weste...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Katarzyna Sroczy ńska Justyna Toto ń-Żurańska Jacek Czepiel Anna Zaj ąc-Grabiec Artur Jurczyszyn Pawe ł Wołkow Tadeusz Librowski Joanna Gdula-Argasi ńska Source Type: research

Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
Biomed Pharmacother. 2022 Feb;146:112579. doi: 10.1016/j.biopha.2021.112579. Epub 2021 Dec 30.ABSTRACTLow grade inflammation is associated with the progression of atherosclerosis. Patients with type 2 diabetes (T2D) have altered cholesterol levels, which are targeted by free radicals to promote lipid peroxidation. Elevated levels of monocyte-associated cytokines such as interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and tumor necrosis factor-alpha (TNF-α), subsequently drive endothelial tissue injury. In fact, the levels of...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Siphamandla R Ngcobo Bongani B Nkambule Tawanda M Nyambuya Kabelo Mokgalaboni Aviwe Ntsethe Vuyolwethu Mxinwa Khanyisani Ziqubu Yonela Ntamo Thembeka A Nyawo Phiwayinkosi V Dludla Source Type: research

Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCbeta(1) signaling pathway in diabetic atherosclerosis
CONCLUSIONS: Diabetes mellitus aggravates chronic inflammation, and promotes atherosclerotic plaques in conjunction with hyperlipidemia, which at least in part through inducing the immune maturation of DCs, and its possible mechanism of action is through the RAGE-TLR4-pPKCβ1 signaling pathway.PMID:35062863 | DOI:10.1186/s10020-022-00431-6 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Liding Zhao Ya Li Tian Xu Qingbo Lv Xukun Bi Xianglan Liu Guosheng Fu Yunzeng Zou Junbo Ge Zhaoyang Chen Wenbin Zhang Source Type: research

ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis
J Pharmacol Sci. 2022 Feb;148(2):197-203. doi: 10.1016/j.jphs.2021.11.005. Epub 2021 Dec 1.ABSTRACTPrevention of atherosclerosis is important because it is a risk factor for cardiovascular diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and triglycerides in peripheral cells. ATP-binding cassette protein A1 (ABCA1) and G1 (ABCG1) are important in eliminating excess cholesterol from cells including macrophages and forming high-density lipoprotein, which contributes to the prevention and regression of atherosclerosis. Enhanced cholesterol efflux activities of ABCA1 and ABCG1 are expected...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Michinori Matsuo Source Type: research

The effects of selenium administration on carotid intima-media thickness and metabolic status in diabetic hemodialysis patients: A randomized, double-blind, placebo-controlled trial
This study was designed to assess the effects of selenium supplementation on CIMT and metabolic profiles of in diabetic hemodialysis (HD) patients.MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was performed on 60 diabetic HD patients. Subjects were randomly assigned to receive selenium supplements or placebo (starch). Individuals in the selenium group (n = 30) received 200 μg selenium per day in the placebo group (n = 30) received for 24 weeks. Fasting blood samples were taken at the study baseline and after 24 weeks of intervention.RESULTS: Following the administration of selenium suppl...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Marzieh Salimian Alireza Soleimani Fereshteh Bahmani Seyed Mohammad Hossein Tabatabaei Zatollah Asemi Hamid Reza Talari Source Type: research

Cardiometabolic Diseases and Female Sexual Dysfunction: Animal Studies
CONCLUSION: Preclinical evidence exists showing cardiometabolic diseases alter the structure and function of female genital tissues. However, similar to clinical studies, there are few studies to draw from, particularly in models of type 2 diabetes, obesity and metabolic syndrome. More studies are required using optimized animal models and methodology to confirm the mechanisms underlying cardiometabolic disease-induced FSD. Angulo J, Hannan JL. Cardiometabolic Diseases and Female Sexual Dysfunction: Animal Studies. J Sex Med 2021;XX:XXX-XXX.PMID:35063393 | DOI:10.1016/j.jsxm.2021.12.009 (Source: Atherosclerosis)
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Javier Angulo Johanna L Hannan Source Type: research

Association of Pericardial Fat with Cardiac Structure, Function and Mechanics: the Multi-Ethnic Study of Atherosclerosis
J Am Soc Echocardiogr. 2022 Jan 18:S0894-7317(22)00007-4. doi: 10.1016/j.echo.2022.01.005. Online ahead of print.ABSTRACTBACKGROUND: Pericardial fat has been associated with adverse cardiovascular outcomes through adiposity-associated inflammation and insulin resistance, which in turn are linked to cardiac dysfunction. We sought to evaluate the association between pericardial fat volume with cardiac structure and function in adults without baseline cardiovascular disease.METHODS: We analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA). Linear regression was used to examine the association between pericardial...
Source: Atherosclerosis - January 22, 2022 Category: Cardiology Authors: Jeff Min Mary E Putt Wei Yang Alain Bertoni Jingzhong Ding Joao A C Lima Matthew A Allison R Graham Barr Nadine Al-Naamani Ravi B Patel Lauren Beussink-Nelson Steven Kawut Sanjiv J Shah Benjamin H Freed Source Type: research