SUMOylation targeting mitophagy in cardiovascular diseases
J Mol Med (Berl). 2022 Sep 26. doi: 10.1007/s00109-022-02258-4. Online ahead of print.ABSTRACTSmall ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases, such as cardiac hypertrophy, hypertension, atherosclerosis, and cardiac ischemia-reperfusion injury. As a multifunctional posttranslational modification molecule in eukaryotic cells, SUMOylation is essentially associated with the regulation of mitochondrial dynamics, especially mitophagy, which is involved in the progression and development of cardiovascular diseases. SUMOylation targeting mitochondrial-associated proteins is admittedly co...
Source: Atherosclerosis - September 27, 2022 Category: Cardiology Authors: Hong Xiao Hong Zhou Gaofeng Zeng Zhenjiang Mao Junfa Zeng Anbo Gao Source Type: research

Aneurysm geometric features effect on the hemodynamic characteristics of blood flow in coronary artery: CFD simulation on CT angiography-based model
Med Biol Eng Comput. 2022 Sep 27. doi: 10.1007/s11517-022-02676-z. Online ahead of print.ABSTRACTThe main purpose of the present numerical study is to evaluate the influences of aneurysm geometric features on the hemodynamic conditions within the left coronary arteries (LCA). Simulations have been conducted in two major parts: Section (I) encompassing three different cases (case 1, case 2, and case 3), in which three various sizes of the bifurcation region ([Formula: see text], [Formula: see text], and [Formula: see text]) were considered for each case, and Section (II) also consists of three distinct cases (case 4, case 5...
Source: Atherosclerosis - September 27, 2022 Category: Cardiology Authors: Ashkan Rafiei Maysam Saidi Source Type: research

Mammalian Sterile 20-Like Kinase 1 Suppresses Atherosclerosis
CONCLUSIONS: Our study reveals that inhibition of the MST1-Cx43 axis is an essential driver of oscillatory shear stress-induced endothelial dysfunction and atherosclerosis, which provides a new therapeutic target for the treatment of atherosclerosis.PMID:36164986 | DOI:10.1161/CIRCRESAHA.122.321322 (Source: Atherosclerosis)
Source: Atherosclerosis - September 27, 2022 Category: Cardiology Authors: Meixi Quan Huizhen Lv Zening Liu Kan Li Chenghu Zhang Lei Shi XinYu Yang Ping Lei Yi Zhu Ding Ai Source Type: research

Yield of Dual Therapy With Statin and Ezetimibe in the Treat Stroke to Target Trial
CONCLUSIONS: In the TST trial (Treat Stroke to Target), targeting an LDL cholesterol of < 70 mg/dL with a combination of statin and ezetimibe compared with 100±10 mg/dL consistently reduced the risk of subsequent stroke.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01252875. URL: clinicaltrialsregister.eu; Unique identifier: EUDRACT2009-A01280-57.PMID:36154103 | DOI:10.1161/STROKEAHA.122.039728 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Pierre Amarenco Jong S Kim Julien Labreuche Hugo Charles Maurice Giroud Byung-Chul Lee Philippa C Lavall ée Marie-H élène Mahagne Elena Meseguer Norbert Nighoghossian Philippe Gabriel Steg Éric Vicaut Eric Bruckert Treat Stroke to Target Investigators Source Type: research

Familial hypercholesterolaemia in children and adolescents: current and future perspective
Curr Pediatr Rev. 2022 Sep 21. doi: 10.2174/1573396318666220921155314. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is a genetic disease, the underlying cause of which is represented by mutations capable of influencing the metabolism of low-density lipoproteins (LDL). The distinguishing characteristic of FH is increased LDL cholesterol blood levels since birth which trigger early development of atherosclerosis-related diseases. Diagnosis of FH is frequently either missed or made with a considerable delay. Prompt identification of the disease is pivotal in implementing early prevention measures. Safe and...
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Francesco Martino Francesco Barilla' Eliana Martino Giuseppe Calcaterra Pier Paolo Bassareo Vassilios Fanos Source Type: research

Circ_0021155 can participate in the phenotypic transformation of human vascular smooth muscle cells via the miR-4459/TRPM7 axis
In conclusion, hsa_circ_0021155 regulates the proliferation, migration and phenotype transformation of VSMCs induced by OX-LDL via the miR-4459/TRPM7 axis. hsa_circ_0021155 and TRPM7 may offer novel therapeutic targets for atherosclerosis.PMID:36155059 | DOI:10.1016/j.bbrc.2022.08.065 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Jinghan Lin Chang Liu Jing Xu Shuang Li Dawei Dai Liming Zhang Pan Yonghui Source Type: research

Plasma l-carnitine and risks of cardiovascular events and recurrent stroke after ischemic stroke: A nested case-control study
CONCLUSIONS: Higher l-carnitine levels were associated with lower risks of cardiovascular events and recurrent stroke after ischemic stroke. Our findings provided evidence supporting plasma l-carnitine as a potential prognostic marker in risk discrimination and stratification in patients with ischemic stroke.TRIAL REGISTRATION: Clinicaltrials.gov as NCT01840072. URL: https://www.CLINICALTRIALS: gov.PMID:36155150 | DOI:10.1016/j.numecd.2022.08.016 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Jigang Du Mengyuan Miao Zian Lu Haichang Chen Anran Bao Bizhong Che Jintao Zhang Zhong Ju Tan Xu Jiang He Yonghong Zhang Chongke Zhong Source Type: research

Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study
CONCLUSIONS: Higher fasting GH was associated with higher risk of all-cause and cardiovascular mortality and improved risk prediction, regardless of sex or race.PMID:36155327 | DOI:10.1016/j.atherosclerosis.2022.09.004 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Nicholas Wettersten Rohit Mital Mary Cushman George Howard Suzanne E Judd Virginia J Howard Monika M Safford Oliver Hartmann Andreas Bergmann Joachim Struck Alan Maisel Source Type: research

Mechanical thrombectomy treatment of basilar artery occlusion within 24 hours of symptom onset: A Single-Center Experience
CONCLUSIONS: The current study suggests that MT treatment of BAO has high recanalization rates and good outcomes.PMID:36155724 | DOI:10.7417/CT.2022.2454 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: N V Phuong N Cong Thanh B Keserci N V Sang N Minh Duc Source Type: research

Structural abnormalities in the non-dilated ascending aortic wall of bicuspid aortic valve patients
CONCLUSIONS: The BAV ascending aorta without dilatation is characterized by a differentiation defect of vascular smooth muscle cells in the media and a significantly thinner intimal layer without overt pathologic features.PMID:36155835 | DOI:10.1016/j.carpath.2022.107478 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Nimrat Grewal Evaldas Girdauskas Mohammed Idhrees Bashi Velayudhan Robert Klautz Antoine Driessen Robert E Poelmann Source Type: research

Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study
CONCLUSIONS: APOE alleles were not associated with IAD in this population-based autopsy study. Lower stenosis in older participants suggests the possibility of attrition bias.PMID:36155836 | DOI:10.1016/j.carpath.2022.107479 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Regina Silva Paradela Daniela Souza Farias-Itao Renata E P Leite Carlos A Pasqualucci Lea T Grinberg Michel Satya Naslavsky Mayana Zatz Ricardo Nitrini Wilson Jacob-Filho Claudia Kimie Suemoto Source Type: research

Diagnostic and therapeutic approach to adult central nervous system vasculitis
Rev Neurol (Paris). 2022 Sep 22:S0035-3787(22)00718-4. doi: 10.1016/j.neurol.2022.05.003. Online ahead of print.ABSTRACTThe clinical manifestations of central nervous system (CNS) vasculitis are highly variable. In the absence of a positive CNS biopsy, CNS vasculitis is particularly suspected when markers of both vascular disease and inflammation are present. To facilitate the clinical and therapeutic approach to this rare condition, CNS vasculitis can be classified according to the size of the involved vessels. Vascular imaging is used to identify medium vessel disease. Small vessel disease can only be diagnosed with a CN...
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: A Nehme M Boulanger A Aouba C Pagnoux M Zuber E Touz é H de Boysson Source Type: research

Curcumin ameliorates oxidized low-density lipoprotein (ox-LDL)-caused damage in human umbilical vein endothelial cells (HUVECs) through the miR-599/MYD88/NF- κB axis
CONCLUSION: Our findings illustrated that curcumin exhibited anti-AS effect through the miR-599/MYD88 axis and thereby inhibiting the NF-κB pathway.PMID:36156291 | DOI:10.1016/j.tiv.2022.105481 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Decai Chen Chongmei Zhu Shouwan Ye Qiong Yang Source Type: research

Targeted delivery strategy: A beneficial partner for emerging senotherapy
Biomed Pharmacother. 2022 Sep 23;155:113737. doi: 10.1016/j.biopha.2022.113737. Online ahead of print.ABSTRACTNumerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non-alcoholic fatty liver, Alzheimer's disease, type 2 diabetes, atherosclerosis, and malignant tumors. With further understanding of cellular senescence, SCs are important effective targets for the treatment of senescence-related diseases, called the Senotherapy. However,...
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Qixiong Zhang Shanshan Li Fengyu Chen Rui Zeng Rongsheng Tong Source Type: research

Findings of optical coherence tomography in saphenous grafts failure. Report of one case
We report a 67 years old diabetic male who underwent coronary surgery in 2009, consulting for an acute coronary syndrome. Angiography showed two different lesions on one aortocoronary venous grafts. OCT demonstrates atherosclerosis in different stages identifying the culprit lesion. Stent placement were successfully carried out.PMID:36156654 | DOI:10.4067/S0034-98872022000200261 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Luis P érez Reinaldo Venegas Guillermo Ibieta Felipe Sep úlveda Jorge Gajardo Eduardo Lecannelier Isabel Robles Maricela Proboste Virginia Segall Contanza Sandoval Source Type: research