Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy
J Drug Target. 2024 Apr 24:1-56. doi: 10.1080/1061186X.2024.2347353. Online ahead of print.ABSTRACTAtherosclerosis (AS) is considered to be one of the major causes of cardiovascular disease. Its pathological microenvironment is characterized by increased production of reactive oxygen species, lipid oxides, and excessive inflammatory factors, which accumulate at the monolayer endothelial cells in the vascular wall to form AS plaques. Therefore, intervention in the pathological microenvironment would be beneficial in delaying AS. Researchers have designed biomimetic nanomedicines with excellent biocompatibility and the abili...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Lijuan Liang Yiping Deng Zuojin Ao Changli Liao Ji Tian Chunhong Li Xin Yu Source Type: research
Histological Findings in the Eyes of Abcc6 Knockout Rat Model of Pseudoxanthoma Elasticum
DISCUSSION: The Abcc6-/- rat model shows that PXE can affect multiple ocular tissues beyond the calcification in Bruch's membrane noted in human eyes. Nodular calcific foci probably correspond to comet lesions seen in patients with PXE. The presence of ectopic calcium without inflammation distinguishes it from inflammatory calcium deposition in atherosclerosis. Further studies are needed to determine why PXE does not cause inflammatory infiltration.TRANSLATIONAL RELEVANCE: The Abcc6-/- murine model may be suitable for studying ocular PXE pathophysiology and ectopic calcification and developing effective therapies.PMID:3865...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Anahita Sehgal Tatyana Milman Qiaoli Li Jose S Pulido Source Type: research
Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics
Curr Nutr Rep. 2024 Apr 24. doi: 10.1007/s13668-024-00531-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Global health concerns persist in the realm of cardiovascular diseases (CVDs), necessitating innovative strategies for both prevention and treatment. This narrative review aims to explore the potential of short-chain fatty acids (SCFAs)-namely, acetate, propionate, and butyrate-as agents in the realm of postbiotics for the management of CVDs.RECENT FINDINGS: We commence our discussion by elucidating the concept of postbiotics and their pivotal significance in mitigating various aspects of cardiovascular diseases. T...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Seyed Sadeq Mousavi Ghahfarrokhi Mohamadsadegh Mohamadzadeh Nasrin Samadi Mohammad Reza Fazeli Sara Khaki Bahman Khameneh Ramin Khameneh Bagheri Source Type: research
< em > Actinidia arguta < /em > Extract Containing < em > Myo < /em > -Inositol Suppresses TNF- < em > α < /em > -Induced VCAM-1 Expression and Monocyte Adhesion to Endothelial Cells via Inhibition of the PTEN/Akt/GSK-3 < em > β < /em > and NF- < em > κ < /em > B Signaling Pathways
J Med Food. 2024 Apr 24. doi: 10.1089/jmf.2023.K.0326. Online ahead of print.ABSTRACTThe primary inflammatory process in atherosclerosis, a major contributor to cardiovascular disease, begins with monocyte adhering to vascular endothelial cells. Actinidia arguta (kiwiberry) is an edible fruit that contains various bioactive components. While A. arguta extract (AAE) has been recognized for its anti-inflammatory characteristics, its specific inhibitory effect on early atherogenic events has not been clarified. We used tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs) for an in vitro...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Jangho Lee Joon Park Kyung-Mo Song Yu Geon Lee Hyo-Kyoung Choi Source Type: research
Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study
CONCLUSIONS: Low to moderate water arsenic levels (<10 µg/L) were associated with T2D incidence in the SHFS and MESA cohorts.PMID:38656975 | DOI:10.2337/dc23-2231 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Maya Spaur Marta Galvez-Fernandez Qixuan Chen Melissa A Lombard Benjamin C Bostick Pam Factor-Litvak Amanda M Fretts Steven J Shea Ana Navas-Acien Anne E Nigra Source Type: research
Global Health Burden of Venous Thromboembolism
Arterioscler Thromb Vasc Biol. 2024 May;44(5):1007-1011. doi: 10.1161/ATVBAHA.124.320151. Epub 2024 Apr 24.NO ABSTRACTPMID:38657032 | DOI:10.1161/ATVBAHA.124.320151 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Aaron Wendelboe Jeffrey I Weitz Source Type: research
Vaping Versus Smoking: Are Electronic-Cigarettes the Savior?
Arterioscler Thromb Vasc Biol. 2024 May;44(5):1012-1015. doi: 10.1161/ATVBAHA.123.319575. Epub 2024 Apr 24.NO ABSTRACTPMID:38657033 | DOI:10.1161/ATVBAHA.123.319575 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: David Bernhard Barbara Messner Source Type: research
Cardiac Lymphangiogenesis in CVDs
Arterioscler Thromb Vasc Biol. 2024 May;44(5):1016-1020. doi: 10.1161/ATVBAHA.123.319572. Epub 2024 Apr 24.NO ABSTRACTPMID:38657034 | DOI:10.1161/ATVBAHA.123.319572 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Ebba Brakenhielm Ibrahim Sultan Kari Alitalo Source Type: research
Century of Milestones and Breakthroughs Related to the Immune Mechanisms of Atherosclerosis
Arterioscler Thromb Vasc Biol. 2024 May;44(5):1002-1006. doi: 10.1161/ATVBAHA.124.319397. Epub 2024 Apr 24.NO ABSTRACTPMID:38657035 | DOI:10.1161/ATVBAHA.124.319397 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Ziad Mallat Alain Tedgui Source Type: research
UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis
CONCLUSION: UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates AS progression in mice by regulating the SMAD7/YAP1 axis.PMID:38657333 | DOI:10.1016/j.molimm.2024.04.001 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Wenbo Li Pengxing Bai Wei Li Source Type: research
Treatment patterns and adherence to lipid-lowering drugs during eight-year follow-up after a coronary heart disease event
CONCLUSIONS: In this long-term follow-up of patients with CHD, less than 70 % used high-intensity statin therapy with only small changes over time, and only 25 % used additional treatment with ezetimibe. We identified factors associated with reduced statin adherence that may be target for interventions.PMID:38657552 | DOI:10.1016/j.atherosclerosis.2024.117550 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Ingrid Engebretsen Christoffer Bugge Henrik St øvring Einar Husebye Elise Sverre Toril Dammen Sigrun Halvorsen John Munkhaugen Source Type: research
Stroke in Asia
Cerebrovasc Dis Extra. 2024 Apr 24. doi: 10.1159/000538928. Online ahead of print.ABSTRACTBackground There is a significant burden of stroke in Asia. Asia has the largest population in the world in 2023, estimated at 4.7 billion. Approximately 9.5-10.6 million strokes will be anticipated annually in the backdrop of a diverse group of well-developed and less developed countries with large disparities in stroke care resources. In addition, Asian countries are in varying phases of epidemiological transition. Summary In this review, we examined recent epidemiological features of ischaemic stroke and intracerebral haemorrhage i...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Kay Sin Tan Jeyaraj Durai Pandian Liping Liu Kazunori Toyoda Thomas Wai Hon Leung Shinichiro Uchiyama Sathoshi Kuroda Nijasri C Suwanwela Sanjith Aaron Hui Meng Chang Narayanaswamy Venketasubramanian Source Type: research
The predictive value of plasma uridine for type 2 diabetes and its atherosclerotic complications
CONCLUSIONS: Fasting uridine has potential as a predictor of diabetes. Δuridine is closely associated with carotid atherosclerosis in patients with T2D.PMID:38657664 | DOI:10.1530/EC-24-0075 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Yueyuan Yang Tingting Yu Zhili Niu Ling Gao Source Type: research
Exosomal long non-coding RNA AU020206 alleviates macrophage pyroptosis in atherosclerosis by suppressing CEBPB-mediated NLRP3 transcription
In conclusion, this study demonstrates that AU020206 delivered by BMSC-EXO alleviates macrophage pyroptosis in AS by blocking CEBPB-mediated transcriptional activation of NLRP3.PMID:38657723 | DOI:10.1016/j.yexcr.2024.114054 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Nan Zhang Yuxin Luo Jiawei Shao Huanhuan Sun Kai Ma Xiang Gao Source Type: research
Limb Outcomes With Ticagrelor Plus Aspirin in Patients With Diabetes Mellitus and Atherosclerosis
CONCLUSIONS: Patients with T2DM and atherosclerosis are at high risk of limb events. Ticagrelor decreased this risk, but increased bleeding. Future trials evaluating the combination of ticagrelor and aspirin would further elucidate the benefit/risk of such therapy in patients with PAD, including those without coronary artery disease. (A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus [THEMIS]: NCT01991795).PMID:38658101 | DOI:10.1016/j.jacc.2024.03.377 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Marc P Bonaca Deepak L Bhatt Tabassome Simon Kim Michael Fox Shamir Mehta Robert A Harrington Lawrence A Leiter Warren H Capell Claes Held Anders Himmelmann Wilhelm Ridderstr åle Jersey Chen Jane J Lee Yang Song Marielle Andersson Jayne Prats Mikhail Kos Source Type: research
