The current landscape for diabetes treatment: Preventing diabetes-associated CV risk
Despite the risk of atherosclerosis has progressively declined over the past few decades, subjects with type 2 diabetes mellitus (T2DM) continue to experience substantial excess of atherosclerotic cardiovascular disease (ASCVD)-related events. Therefore, there is urgent need to treat ASCVD disease in T2DM earlier, more intensively, and with greater precision. Many factors concur to increase the risk of atherosclerosis, and multifactorial intervention remains the basis for effective prevention or reduction of atherosclerotic events. (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Angela Dardano, Cristina Bianchi, Monia Garofolo, Stefano Del Prato Source Type: research
Hypertensive disorders of pregnancy and long-term maternal cardiovascular risk: Bridging epidemiological knowledge into personalized postpartum care and follow-up
Pregnancy Hypertens. 2024 Apr 20;36:101127. doi: 10.1016/j.preghy.2024.101127. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is globally the leading cause of death and disability. Sex-specific causes of female CVD are under-investigated. Pregnancy remains an underinvestigated sex-specific stress test for future CVD and a hitherto missed opportunity to initiate prevention of CVD at a young age. Population-based studies show a strong association between female CVD and hypertensive disorders of pregnancy. This association is also present after other pregnancy complications that are associated with placental dysfu...
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Anne Cathrine Staff Maria Laura Costa Ralf Dechend Daniel P Jacobsen Meryam Sugulle Source Type: research
Safety and effectiveness of anticoagulation in the management of acute stroke and transient ischemic attack due to intracranial and extracranial non-occlusive thrombus
CONCLUSION: Anticoagulant treatment is safe and effective in symptomatic patients with intracranial or extracranial artery nonocclusive thrombus, regardless of the anticoagulant type, thrombus location and size.PMID:38643651 | DOI:10.1016/j.jocn.2024.04.012 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Aysenur Onalan Erdem Gurkas Cetin Kursad Akpinar Ozlem Aykac Zehra Uysal Kocabas Hasan Dogan Musa Temel Atilla Ozcan Ozdemir Source Type: research
Thrombus histology does not predict stroke etiological subtype but influences recanalization
CONCLUSION: There was no correlation between thrombus histology and the etiological stroke subtype. However, clot composition predicted the degree of recanalization and number of passes.PMID:38643652 | DOI:10.1016/j.jocn.2024.04.013 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: K Y Manisha Rajalakshmi Poyuran Deepthi Narasimhaiah Naveen Kumar Paramasivan Harikrishnan Ramachandran Sapna Erat Sreedharan Jayadevan Er Santhosh Kumar Jissa Vinoda Thulaseedharan P N Sylaja Source Type: research
Outcomes of management strategies in patients with prior coronary artery bypass grafting presenting with an acute coronary syndrome
CONCLUSIONS: Patients with prior CABG presenting with an ACS are often treated conservatively without PCI, which is associated with a higher risk of adverse events.PMID:38643672 | DOI:10.1016/j.atherosclerosis.2024.117477 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Pishoy Gouda Sunjidatul Islam Douglas C Dover Padma Kaul Kevin R Bainey Robert C Welsh Source Type: research
Enhanced identification of familial hypercholesterolemia using central laboratory algorithms
CONCLUSIONS: The identification of a substantial number of previously undiagnosed and un(der)treated clinical and genetic FH patients within a central laboratory database highlights the feasibility and clinical potential of this targeted screening strategy; both in identifying new FH patients and in improving treatment in this high-risk population.PMID:38643673 | DOI:10.1016/j.atherosclerosis.2024.117548 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Shirin Ibrahim Nick S Nurmohamed Melchior C Nierman Jim N de Goeij Linda Zuurbier Jeroen van Rooij Willemijn A M Schonck Jard de Vries G Kees Hovingh Laurens F Reeskamp Erik S G Stroes Source Type: research
Effect of bempedoic acid on mortality and cardiovascular events in primary and secondary prevention: A post-hoc analysis of the CLEAR-outcomes trial
CONCLUSION: In contrast to its effect in the primary prevention subgroup of CLEAR - Outcomes, bempedoic acid resulted in a more modest MACE reduction and a potential increase in mortality in the secondary prevention subgroup. Whether these findings represent true treatment effect heterogeneity or the play of chance requires further evidence.PMID:38643794 | DOI:10.1016/j.ijcard.2024.132074 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Ahmed Sayed James M Brophy Source Type: research
Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling and Subclinical Right Ventricular Dysfunction in Older Aged Healthy Adults: The Multi-Ethnic Study of Atherosclerosis
CONCLUSION: Among older community-dwelling adults free of heart failure and pulmonary hypertension, both FAC/PASP and TAPSE/PASP ratios are optimal for assessment of RV-PA coupling based on its association with 6MWD, NT-proBNP, and KCCQ score. FAC/PASP ratio has the additional benefit of reflecting age and sex-related geometric and functional changes.PMID:38643925 | DOI:10.1016/j.amjcard.2024.03.043 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Vivek P Jani Jordan B Strom Abhishek Gami Lauren Beussink-Nelson Ravi Patel Erin D Michos Sanjiv J Shah Benjamin H Freed Monica Mukherjee Source Type: research
Pericarotid Adipose Tissue is Associated with Circulatory Markers of Inflammation and Carotid Atherosclerosis
Angiology. 2024 Apr 21:33197241248776. doi: 10.1177/00033197241248776. Online ahead of print.ABSTRACTPerivascular adipose tissue plays roles in vascular inflammation and atherosclerosis. The present study aimed to evaluate the association between pericarotid fat density (PFD) and circulatory inflammatory indicators, internal carotid artery (ICA) stenosis, and vulnerable carotid plaques. We retrospectively screened 498 consecutive patients who underwent both computed tomography angiography of the neck between January 2017 and December 2020. The PFD, ICA stenosis, and vulnerable carotid plaques were analyzed using establishe...
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Lingqun Mao Linkao Chen Man Qu Xinwei He Source Type: research
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta
In this study, RNAi screening in human aortic smooth muscle cells was performed to explore the effects of OTU family deubiquitinases, which revealed that silencing OTUB1 inhibited PDGF-BB-stimulated VSMC phenotype switch. Further in vivo studies using Apoe-/- mice revealed that knockdown of OTUB1 in VSMCs alleviated atherosclerosis plaque burden in the advanced stage and led to a stable plaque phenotype. Moreover, VSMC proliferation and migration upon PDGF-BB stimulation could be inhibited by silencing OTUB1 in vitro. Unbiased RNA-sequencing data indicated that knocking down OTUB1 influenced VSMC differentiation, adhesion,...
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Fei Xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong Shen Chaofu Li Yue Yu Zhiqiang Pei Li Shen Juying Qian Junbo Ge Source Type: research
Risk of cardiovascular disorders in hidradenitis suppurativa patients: a large-scale, propensity-matched global retrospective cohort study
CONCLUSIONS: This is the most extensive study on the association of HS with CVDs. We demonstrated that HS patients are at significantly greater risk of developing various CVDs compared to matched controls, with heart failure being the most common one.PMID:38644522 | DOI:10.1111/ijd.17186 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Piotr K Krajewski Łukasz Matusiak Sascha St änder Diamant Tha çi Jacek C Szepietowski Henner Zirpel Source Type: research
Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability
CONCLUSION: We developed and validated the GCI, a novel CGM metric that captures the shape of glucose variability using the periodogram signal decomposition. Glucose Color Index was reliable within participants over a three-month period and associated with diabetes comorbidities. The GCI suggests a promising avenue toward the development of CGM metrics which more fully incorporate time series information.PMID:38641966 | DOI:10.1177/19322968241245654 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Joseph Sartini Michael Fang Mary R Rooney Elizabeth Selvin Josef Coresh Scott Zeger Source Type: research
Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPAR γ
CONCLUSIONS: Collectively, this evidence reveals an important role of TRAF5 in the development of intimal hyperplasia through the regulation of macrophage polarization, which provides a promising target for arterial restenosis-related disease management.PMID:38642079 | DOI:10.1007/s00011-024-01875-8 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Wen-Lin Cheng Sheng-Ping Chao Fang Zhao Huan-Huan Cai Ziyue Zeng Jian-Lei Cao Zhili Jin Ke-Qiong Deng Xiaorong Hu Hairong Wang Zhibing Lu Source Type: research
The MMP-9 promoter genetic variant rs3918242, mRNA and protein expression in advanced carotid plaque tissue
CONCLUSIONS: Considering the differences of MMP-9 mRNA and protein expression in CP tissue regarding different plaque phenotypes and the observed sex-specific effect, the role of MMP-9 in human atherosclerotic plaques should be further elucidated.PMID:38642151 | DOI:10.1007/s11033-024-09458-w (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Maja Zivkovic Aleksandra Stankovic Igor Koncar Ana Kolakovic Maja Boskovic Tamara Djuric Source Type: research
Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13
Sci Rep. 2024 Apr 20;14(1):9073. doi: 10.1038/s41598-024-59672-6.ABSTRACTADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active protease and is not inhibited by circulating protease inhibitors. Therefore, the mechanisms that regulate ADAMTS13 protease activity are unknown. We performed an unbiased proteomics screen to identify ligands of ADAMTS13 by optimizing the application of BioID to plasma. Plasma BioID identified 5 plasma proteins signi...
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Hasam Madarati Veronica DeYoung Kanwal Singh Taylor Sparring Andrew C Kwong James C Fredenburgh Cherie Teney Marlys L Koschinsky Michael B Boffa Jeffrey I Weitz Colin A Kretz Source Type: research
