S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications
Redox Biol. 2024 Apr 4;72:103144. doi: 10.1016/j.redox.2024.103144. Online ahead of print.ABSTRACTNitric oxide (NO) is a key signalling molecule released by vascular endothelial cells that is essential for vascular health. Low NO bioactivity is associated with cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure and NO donors are a mainstay of drug treatment. However, many NO donors are associated with the development of tolerance and adverse effects, so new formulations for controlled and targeted release of NO would be advantageous. Herein, we describe the design and characterisation of a nov...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Tanveer A Tabish Mian Zahid Hussain Sevasti Zervou William K Myers Weiming Tu Jiabao Xu Irina Beer Wei E Huang Rona Chandrawati Mark J Crabtree Paul G Winyard Craig A Lygate Source Type: research
Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway
CONCLUSION: Geniposide alleviated AS by restoring PARP1/PI3K/AKT signaling pathway-suppressed lipophagy. This study is the first to present the lipophagy-inducing effect of Geniposide and the binding of ABCG1 and PLIN1 inhibited by PARP1.PMID:38614041 | DOI:10.1016/j.phymed.2024.155617 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Jinhai Lin Xiaolong Wang Mingyang Gu Yuanyuan Chen Jiongbo Xu Nhi Van Chau Junlong Li Xiaodong Ji Qingmin Chu Lijin Qing Wei Wu Source Type: research
Potential Mechanisms of Guizhi Fuling Wan in Treating Endometriosis: An Analysis Based on TCMSP and DisGeNET Databases
CONCLUSIONS: The current review revealed that endometriosis is highly associated with aberrant inflammatory, angiogenic, and apoptotic activities. The therapeutic effects of GFW on endometriosis are likely to act through regulating these activities.PMID:38614264 | DOI:10.1016/j.jep.2024.118190 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Jian-Looi Yee Chun-Yen Huang Ya-Chun Yu S Joseph Huang Source Type: research
Sleep measures and cardiovascular disease in type 2 diabetes mellitus
CONCLUSIONS: Poor sleep quality and higher RDW levels are associated with macrovascular disease in a T2DM population. Increased BMI as well as depression also appear to have an independent role in subclinical atherosclerosis, as assessed by CIMT.PMID:38614653 | DOI:10.7861/clinmed.2022-0442 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Caroline J Magri Sara Xuereb Rachel-Anne Xuereb Robert G Xuereb Stephen Fava Joseph Galea Source Type: research
Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE(-/-) Mice
CONCLUSIONS: Our study indicates that MerTK decrease in macrophages contributes to the aggravated atherosclerosis in diabetic ApoE-/- mice and regional restoration of MerTK in macrophages of the plaque via HMNVs could be a promising therapeutic approach.PMID:38614985 | PMC:PMC11015613 | DOI:10.1186/s12951-024-02463-y (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Shuo Qiu Jiahan Liu Jianmei Chen Yangni Li Te Bu Zhelong Li Liang Zhang Wenqi Sun Tian Zhou Wei Hu Guodong Yang Lijun Yuan Yunyou Duan Changyang Xing Source Type: research
Rosuvastatin-Based Lipid-Lowering Therapy for the Control of LDL Cholesterol in Patients at High Vascular Risk
J Clin Med. 2024 Mar 25;13(7):1894. doi: 10.3390/jcm13071894.ABSTRACTVascular diseases are the leading cause of death in Spain. Hypercholesterolemia is not only a cardiovascular risk factor, but also underlies the etiopathogenesis of atherosclerosis. Therefore, reducing LDL cholesterol (LDL-C) to the goals recommended by clinical practice guidelines, is essential to decrease the risk of vascular complications. Despite this, current LDL-C control is scarce, even in subjects with high and very high risk. This is mainly due to an insufficient intensification of lipid-lowering treatment. In this context, it is essential to pre...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Jose Mar ía Mostaza Carlos Escobar Source Type: research
The Net Clinical Outcome of Dual-Pathway Inhibition in Clinical Practice: The "Xarelto plus Acetylsalicylic Acid: Treatment Patterns and Outcomes in Patients with Atherosclerosis" Registry
Conclusions: In the real-world XATOA registry, the annual rate of NCO events was low and numerically similar to those seen in the treatment group in the randomized COMPASS trial.PMID:38610724 | DOI:10.3390/jcm13071956 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Alexander Breitenstein Alain Gay Kai Vogtl änder Keith A A Fox Jan Steffel XATOA Publication Committee Source Type: research
Coronary Plaque in Athletes
J Clin Med. 2024 Apr 1;13(7):2044. doi: 10.3390/jcm13072044.ABSTRACTThe relationship between vigorous physical activity (PA) and the development of coronary atherosclerosis has remained less explored for many years. Recently, literature data have focused on coronary atherosclerosis in athletes showing that prevalence is not trivial, that there are differences among various types of sport, and that there are some peculiar features. As a matter of fact, plaque composition in athletes seems to be characterized by calcium rather than soft components. Specific mechanisms through which vigorous PA influences coronary artery dise...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Elisabetta Tonet Matteo Arzenton Marco De Pietri Luca Canovi Davide Lapolla Alberto Sarti Veronica Amantea Andrea Raisi Gianni Mazzoni Gianluca Campo Giovanni Grazzi Source Type: research
Updated Estimates of Radiation Risk for Cancer and Cardiovascular Disease: Implications for Cardiology Practice
J Clin Med. 2024 Apr 2;13(7):2066. doi: 10.3390/jcm13072066.ABSTRACTThis review aims to furnish an updated assessment of the societal healthcare load, including cancer and cardiovascular disease resulting from diagnostic radiologic operations. The previously projected additional cancer risk of 0.9% in a United States 2004 study referred to radiological conditions in 1996 with an X-ray exposure of 0.50 millisievert (mSv) per capita annually. Radiological exposure (radiology + nuclear medicine) has escalated to 2.29 mSv (2016) per capita per year. Low-dose exposures were previously assumed to have a lower biological impact, ...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Eugenio Picano Eliseo Vano Source Type: research
Pathological Findings of Donor Vessels in Bypass Surgery
Conclusions This is the first study to histologically evaluate the pathological findings of donor vessels according to disease. The proportion of dissection findings indicative of vascular damage due to surgical manipulation was not statistically different between the different conditions.PMID:38610890 | DOI:10.3390/jcm13072125 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Yohei Nounaka Yasuo Murai Asami Kubota Atsushi Tsukiyama Fumihiro Matano Kenta Koketsu Akio Morita Source Type: research
Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research
Arterial Calcification Disappearance in Breast Imaging: A Key Indicator for Transition to Invasive Ductal Carcinoma
Diagnostics (Basel). 2024 Mar 29;14(7):727. doi: 10.3390/diagnostics14070727.ABSTRACTA woman in her 70s, initially suspected of having fibroadenoma due to a well-defined mass in her breast, underwent regular mammography and ultrasound screenings. Over several years, no appreciable alterations in the mass were observed, maintaining the fibroadenoma diagnosis. However, in the fourth year, an ultrasound indicated slight enlargement and peripheral irregularities in the mass, even though the mammography images at that time showed no alterations. Interestingly, mammography images over time showed the gradual disappearance of pre...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Arisa Sato Tomoyuki Fujioka Iichiroh Onishi Emi Yamaga Leona Katsuta Kazunori Kubota Yuichi Kumaki Toshiyuki Ishiba Goshi Oda Ukihide Tateishi Source Type: research
Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease-Is There a Link?
Int J Mol Sci. 2024 Mar 30;25(7):3885. doi: 10.3390/ijms25073885.ABSTRACTNon-obstructive coronary artery disease (NO-CAD) constitutes a heterogeneous group of conditions collectively characterized by less than 50% narrowing in at least one major coronary artery with a fractional flow reserve (FFR) of ≤0.80 observed in coronary angiography. The pathogenesis and progression of NO-CAD are still not fully understood, however, inflammatory processes, particularly atherosclerosis and microvascular dysfunction are known to play a major role in it. Chemokine fractalkine (FKN/CX3CL1) is inherently linked to these processes. FKN/C...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Aleksandra Stangret Karol Artur Sadowski Konrad Jab łoński Janusz Kochman Grzegorz Opolski Marcin Grabowski Mariusz Tomaniak Source Type: research
The Role of Stem Cells in the Treatment of Cardiovascular Diseases
Int J Mol Sci. 2024 Mar 31;25(7):3901. doi: 10.3390/ijms25073901.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of death and include several vascular and cardiac disorders, such as atherosclerosis, coronary artery disease, cardiomyopathies, and heart failure. Multiple treatment strategies exist for CVDs, but there is a need for regenerative treatment of damaged heart. Stem cells are a broad variety of cells with a great differentiation potential that have regenerative and immunomodulatory properties. Multiple studies have evaluated the efficacy of stem cells in CVDs, such as mesenchymal stem cells and induced...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Estera Bakinowska Kajetan Kie łbowski Dominika Boboryko Aleksandra Wiktoria Bratborska Joanna Olejnik-Wojciechowska Marcin Rusi ński Andrzej Pawlik Source Type: research
Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research
