Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Conclusions. South Asian subgroups with higher risk of weight and/or waist gain may benefit from targeted interventions to improve health outcomes.PMID:38585953 | PMC:PMC10996820 | DOI:10.21203/rs.3.rs-4054151/v1 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Sujatha Seetharaman Isabel Allen Meghana Gadgil Shylaja Sriniva Lisa Topor Alka Kanaya Source Type: research
Significance of the Wnt signaling pathway in coronary artery atherosclerosis
CONCLUSIONS: This study demonstrates the upregulation of three important members of canonical and non-canonical Wnt signaling pathways and their receptors in coronary atherosclerosis and shows an important role for these molecules in plaque development through increased cellular remodeling and impaired cholesterol handling.PMID:38586172 | PMC:PMC10995361 | DOI:10.3389/fcvm.2024.1360380 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Kashif Khan Bin Yu Jean-Claude Tardif Eric Rh éaume Hamood Al-Kindi Sabin Filimon Cristina Pop Jacques Genest Renzo Cecere Adel Schwertani Source Type: research
Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review
Front Neurosci. 2024 Mar 22;18:1372326. doi: 10.3389/fnins.2024.1372326. eCollection 2024.ABSTRACTDue to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (MCI) as well as dementia. Sleep disorders are discussed both as a risk factor for and as a consequence of MCI/dementia. Cross-sectional and longitudinal population-based as well as case-control studies revealed sleep disorders, especially sleep-disorderded breathing...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Geert Mayer Helmut Frohnhofen Martha Jokisch Dirk M Hermann Janine Gronewold Source Type: research
Deciphering thyroid function and CIMT: a Mendelian randomization study of the U-shaped influence mediated by apolipoproteins
CONCLUSION: This research establishes a causal link between thyroid function and CIMT using MR methods, underscoring the importance of monitoring thyroid function for early cardiovascular risk assessment. The results advocate for the consideration of thyroid hormone supplementation in hypothyroid patients as a strategy to mitigate the risk of carotid atherosclerosis. These insights pave the way for more targeted approaches in managing patients with thyroid dysfunction to prevent cardiovascular complications.PMID:38586463 | PMC:PMC10995244 | DOI:10.3389/fendo.2024.1345267 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Ming-Zhu Zhang Cong Zhao Xiao-Ming Xing Jie Lv Source Type: research
A dual-targeting therapeutic nanobubble for imaging-guided atherosclerosis treatment
Mater Today Bio. 2024 Mar 22;26:101037. doi: 10.1016/j.mtbio.2024.101037. eCollection 2024 Jun.ABSTRACTAtherosclerosis is a cardiovascular disease that seriously endangers human health. Low shear stress (LSS) is recognized as a vital factor in causing chronic inflammatory and further inducing the occurrence and development of atherosclerosis. Targeting imaging and treatment are of substantial significance for the diagnosis and therapy of atherosclerosis. On this ground, a kind of ultrasound (US) imaging-guided therapeutic polymer nanobubbles (NBs) with dual targeting of magnetism and antibody was rationally designed and co...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Jie Lin Xiaoying Chen Yi Li Luodan Yu Yu Chen Bo Zhang Source Type: research
Ox-LDL-induced CD80 < sup > + < /sup > macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients
Am J Physiol Cell Physiol. 2024 Apr 8. doi: 10.1152/ajpcell.00043.2024. Online ahead of print.ABSTRACTAtherosclerosis is an inflammatory disease of blood vessels involving the immune system. Natural killer T (NKT) cells, as crucial components of the innate and acquired immune systems, play critical roles in the development of atherosclerosis. However, the mechanism and clinical relevance of NKT cells in early atherosclerosis are largely unclear. Our findings demonstrated that there were higher populations of NKT cells and interferon gamma (IFN-γ)-producing NKT cells in the peripheral blood of patients with hyperlipidemia ...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Yin Wang Yao Zou Qingsong Jiang Wenming Li Xinyu Chai Tingrui Zhao Siyi Liu Zhiyi Yuan Chao Yu Tingting Wang Source Type: research
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial
CONCLUSIONS: Among patients having cardiac surgery, topical administration of tranexamic acid resulted in an 8.3% absolute increase in transfusion without reducing the incidence of seizure, compared to intravenous tranexamic acid.PMID:38587333 | DOI:10.1161/CIRCULATIONAHA.124.069606 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Andr é Lamy Dmitry A Sirota Frederic Jacques Ahmad Poostizadeh Nicolas Noiseux Sergey Efremov Philippe Demers Boris Akselrod Chew Yin Wang Rakesh C Arora Piotr Branny Shay P McGuinness Craig D Brown Hugues Jeanmart Qiang Zhao Haibo Zhang Emilie P Belley- Source Type: research
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis
CONCLUSIONS: This study evaluated the expression changes of PANoptosis-related genes in atherosclerosis, providing a reference direction for the study of PANoptosis in atherosclerosis and offering potential new avenues for further understanding the pathogenesis and treatment strategies of atherosclerosis.PMID:38587531 | DOI:10.1007/s00011-024-01877-6 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Zhipeng Zheng Kaiyuan Li Zhiyuan Yang Xiaowen Wang Cheng Shen Yubin Zhang Huimin Lu Zhifeng Yin Min Sha Jun Ye Li Zhu Source Type: research
The effect of significant weight loss after bariatric surgery on echocardiographic indices: an observational study focusing on left ventricular deformation by 2D speckle echocardiography and right ventricular size
CONCLUSIONS: Bariatric surgery could enhance cardiac function, as proven by 2D speckle echocardiography. Changes in RV size may be related to weight loss and should be considered when assessing patients who have undergone bariatric surgery.PMID:38587759 | DOI:10.1186/s43044-024-00474-6 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Saeed Safari Mozhgan Parsaee Mohammad Moradi Mahdi Hakiminejad Parisa Koohsari Farnoosh Larti Source Type: research
Public Health Relevance of US EPA Air Quality Index Activity Recommendations
CONCLUSIONS AND RELEVANCE: These findings suggest that existing PM2.5 AQI activity recommendations are of questionable public health relevance in present-day conditions and merit consideration for updating to improve their potential effectiveness.PMID:38587845 | DOI:10.1001/jamanetworkopen.2024.5292 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Robert D Brook Sanjay Rajagopalan Sadeer Al-Kindi Source Type: research
Single-Cell Multimodal Profiling of Atherosclerosis Identifies CD200 as a Cell Surface Lineage Marker of Vascular Smooth Muscle Cells and Their Derived Cells
Circulation. 2024 Apr 9;149(15):1231-1233. doi: 10.1161/CIRCULATIONAHA.123.067092. Epub 2024 Apr 8.NO ABSTRACTPMID:38588334 | DOI:10.1161/CIRCULATIONAHA.123.067092 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Alexander C Bashore Allen Chung Chinyere Ibikunle Hanying Yan Chenyi Xue Mingyao Li Robert C Bauer Muredach P Reilly Source Type: research
Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle
Circulation. 2024 Apr 9;149(15):1202-1204. doi: 10.1161/CIRCULATIONAHA.124.067882. Epub 2024 Apr 8.NO ABSTRACTPMID:38588335 | DOI:10.1161/CIRCULATIONAHA.124.067882 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: M Luisa Iruela-Arispe Source Type: research
Early-onset versus late-onset preeclampsia and risk of coronary atherosclerosis later in life: a clinical follow-up study
CONCLUSIONS: Women with early-onset preeclampsia had a slightly higher risk of coronary atherosclerosis compared to women with late-onset preeclampsia. However, based on the current evidence it does not seem indicated to limit screening, diagnostic and preventive measures for cardiovascular disease only to women with early-onset preeclampsia.PMID:38588914 | DOI:10.1016/j.ajogmf.2024.101371 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Maria G Hauge Jesper J Linde Klaus F Kofoed Anne S Ersb øll Marianne Johansen Per E Sigvardsen Andreas Fuchs Anders P Mikkelsen Finn Gustafsson Peter Damm Source Type: research
Management of carotid atherosclerosis in stroke
Pract Neurol. 2024 Apr 8:pn-2023-003918. doi: 10.1136/pn-2023-003918. Online ahead of print.ABSTRACTInternal carotid artery atherosclerosis is a major risk factor for stroke, accounting for 15-20% of ischaemic strokes. Revascularisation procedures-either carotid endarterectomy or carotid artery stenting-can reduce the risk of stroke for those with significant (>50%) luminal stenosis but particularly for those with more severe (70-99%) stenosis. However, advances in medical pharmacotherapy have implications for the relative benefit from surgery for symptomatic carotid atherosclerosis, as well as our approach to asymptoma...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Nicholas Richard Evans Shiv Bhakta Mohammed M Chowdhury Hugh Markus Elizabeth Warburton Source Type: research
RSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells
Sci Rep. 2024 Apr 8;14(1):8196. doi: 10.1038/s41598-024-58592-9.ABSTRACTIn atherosclerotic lesions, monocyte-derived macrophages are major source of interferon gamma (IFN-γ), a pleotropic cytokine known to regulate the expression of numerous genes, including the antiviral gene RSAD2. While RSAD2 was reported to be expressed in endothelial cells of human carotid lesions, its significance for the development of atherosclerosis remains utterly unknown. Here, we harnessed publicly available human carotid atherosclerotic data to explore RSAD2 in lesions and employed siRNA-mediated gene-knockdown to investigate its function in ...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Assim Hayderi Ashok K Kumawat Vladimir S Shavva Mats Dreifaldt Birgitta Sigvant Marcelo H Petri Bj örn Kragsterman Peder S Olofsson Allan Sirsj ö Liza U Ljungberg Source Type: research
