Urotensin II receptor deficiency ameliorates ligation-induced carotid intimal hyperplasia partially through the RhoA-YAP1 pathway
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167170. doi: 10.1016/j.bbadis.2024.167170. Online ahead of print.ABSTRACTIntimal hyperplasia (IH) is a common pathological feature of vascular proliferative diseases, such as atherosclerosis and restenosis after angioplasty. Urotensin II (UII) and its receptor (UTR) are widely expressed in cardiovascular tissues. However, it remains unclear whether the UII/UTR system is involved in IH. Right unilateral common carotid artery ligation was performed and maintained for 21 days to induce IH in UTR knockout (UTR-/-) and wild-type (WT) mice. Histological analysis revealed that compa...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Panpan Wei Kangli Tian Haole Liu Kexin Li Naqash Alam Daxin Cheng Meng Li Xue He Jia Guo Rong Wang Weirong Wang Liang Bai Enqi Liu Baohui Xu Yankui Li Sihai Zhao Source Type: research
In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion
Food Chem Toxicol. 2024 Apr 15;188:114663. doi: 10.1016/j.fct.2024.114663. Online ahead of print.ABSTRACTThe effect of endothelial cells' exposure to dibutyl phthalate (DBP) on monocyte adhesion is largely unknown. We evaluated monocyte adhesion to DBP-exposed endothelial cells by combining three approaches: short-term exposure (24 h) of EA.hy926 cells to 10-6, 10-5, and 10-4 M DBP, long-term exposure (12 weeks) of EA.hy926 cells to 10-9, 10-8, and 10-7 M DBP, and exposure of rats (28 and 90 days) to 100, 500, and 5000 mg DBP/kg food. Monocyte adhesion to human EA.hy926 and rat aortic endothelial cells, expression of selec...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Dunja Kokai Jelena Markovic Filipovic Marija Opacic Ivana Ivelja Vojislav Banjac Bojana Stanic Nebojsa Andric Source Type: research
Jiawei Dachaihu decoction protects against mitochondrial dysfunction in atherosclerosis (AS) mice with chronic unpredictable mild stress (CUMS) via SIRT1/PGC-1alpha/TFAM/LON signaling pathway
CONCLUSION: Jiawei Dachaihu extract could alleviate AS and reduce CUMS by upregulating the SIRT1/PGC-1α signaling and promoted its crosstalk with Lon protein to maintain mitochondrial stability.PMID:38631487 | DOI:10.1016/j.jep.2024.118150 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Haijiao Shi Miao Sun Shuai Wang Fanyu He Ronglai Yang Zheng Li Wei Chen Fengrong Wang Source Type: research
Long-term outcomes of endovascular therapy for right subclavian artery occlusive lesions: A multi-center experience
CONCLUSIONS: Endovascular treatment of right subclavian artery lesions is safe, effective, and technically achievable. The reasonable use of balloon-expandable stents can achieve satisfactory outcomes with accurate orientation and promising patency.PMID:38631687 | DOI:10.1177/17085381241247613 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yulong Huang Xinsheng Xie Guoqiang Huang Weifeng Lu Shichai Hong Yihui Chen Yue Lin Weiguo Fu Xiang Hong Lixin Wang Source Type: research
Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort
CONCLUSIONS: The study shows, in a large U.S. pooled cohort, that higher Lp(a) levels are associated with an increased ASCVD risk, including in patients with diabetes.PMID:38631771 | DOI:10.1016/j.jacc.2024.02.031 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Nathan D Wong Wenjun Fan Xingdi Hu Christie Ballantyne Ron C Hoodgeveen Michael Y Tsai Auris Browne Matthew J Budoff Source Type: research
Measurement and Application of Incidentally Detected Coronary Calcium: JACC Review Topic of the Week
J Am Coll Cardiol. 2024 Apr 23;83(16):1557-1567. doi: 10.1016/j.jacc.2024.01.039.ABSTRACTCoronary artery calcium (CAC) scoring is a powerful tool for atherosclerotic cardiovascular disease risk stratification. The nongated, noncontrast chest computed tomography scan (NCCT) has emerged as a source of CAC characterization with tremendous potential due to the high volume of NCCT scans. Application of incidental CAC characterization from NCCT has raised questions around score accuracy, standardization of methodology including the possibility of deep learning to automate the process, and the risk stratification potential of an ...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Shyon Parsa Adam Saleh Viraj Raygor Natalie Hoeting Anjali Rao Ann Marie Navar Anand Rohatgi Fernando Kay Suhny Abbara Amit Khera Parag H Joshi Source Type: research
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period
CONCLUSIONS: Risk chart algorithms are very useful for discriminating PsA at low and high CV risk. An integrated model featuring QRISK3 and SCORE2 yielded the optimal synergy of QRISK3's discrimination ability and SCORE2's calibration accuracy.PMID:38631846 | DOI:10.1136/rmdopen-2024-004207 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Jessica Polo Y La Borda Santos Casta ñeda Elena Heras-Recuero Fernando S ánchez-Alonso Zulema Plaza Carmen Garc ía Gómez Ivan Ferraz-Amaro Jes ús Tomás Sanchez-Costa Olga Carmen S ánchez-González Ana Isabel Turri ón-Nieves Ana Perez-Alcal á Caro Source Type: research
Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Facilitates Foam Cell Formation and Atherosclerosis Progression Through the miR-17-5p/Itchy E3 Ubiquitin Protein Ligase (ITCH)/Liver Kinase B1 (LKB1) Axis
CONCLUSIONS: NEAT1 accelerated foam cell formation during AS progression through the miR-17-5p/ITCH/LKB1 axis.PMID:38631864 | DOI:10.1253/circj.CJ-23-0769 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Haifen Huang Bin Peng Qingyong Chen Yi Wang Ren Li Source Type: research
Carotid Plaque Burden in Patient who Underwent Coronary Angiogram at Dhulikhel Hospital
Conclusion This study establishes a relationship between coronary artery disease and carotid plaque, suggesting that the presence of carotid plaque may serve as an indicator of underlying coronary artery disease.PMID:38628010 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: S Humagain S R Pathak R P Koju Source Type: research
Study of active components and mechanisms mediating the hypolipidemic effect of < em > Inonotus obliquus < /em > polysaccharides
Food Sci Nutr. 2024 Feb 6;12(4):2833-2845. doi: 10.1002/fsn3.3964. eCollection 2024 Apr.ABSTRACTHyperlipidemia is a multifaceted metabolic disease, which is the major risk factor for atherosclerosis and cardiovascular diseases. Traditional Chinese medicine provides valuable therapeutic strategies in the treatment of hyperlipidemia. Inonotus obliquus has been used in traditional medicine to treat numerous diseases for a long time. To screen and isolate the fractions of I. obliquus polysaccharides (IOP) that can reduce blood lipid in the hyperlipemia animals and cell models, and investigate its mechanisms. The active compone...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Guanwen Ding Xiao Guo Xiao Li Liping An Huawen Shi Source Type: research
Positive orientation and health behaviors in older patients with atherosclerosis
CONCLUSIONS: There is a positive relationship between positive orientation and health behaviors. Positive orientation can be enhanced through appropriate psychoeducation and psychological support to prevent ill health and improve treatment of patients with atherosclerosis.PMID:38628275 | PMC:PMC11016943 | DOI:10.5114/hpr/163536 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Krzysztof K Suppan Ma łgorzata Basińska Aleksandra B łachnio Source Type: research
Internuclear ophthalmoplegia following radial artery cardiac catheterization approach: An unusual presentation
We report a rare case in a 47-year-old man presenting with diplopia after radial artery angioplasty. Although the symptoms were resolved after 60 days, diagnosing this obstacle is necessary to reduce the patient and physician's anxiety.PMID:38628413 | PMC:PMC11017003 | DOI:10.4103/sjopt.sjopt_2_23 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Seyed H Daryabari Seyed A Mosavi Seyed H Sharoubandi Hooman Zarei Source Type: research
A bibliometric analysis of the 100 most-cited clinical articles in the research of intracranial artery stenosis and intracranial atherosclerosis
CONCLUSION: The findings of this study provide novel insight into this field and will facilitate future research endeavors.PMID:38628533 | PMC:PMC11021113 | DOI:10.25259/SNI_1030_2023 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yudai Hirano Satoru Miyawaki Yusuke Sakaguchi Satoshi Koizumi Hiroki Hongo Nobuhito Saito Source Type: research
Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis
This study underscores the shared pathogenic mechanisms, pivotal genes, and potential therapeutic interventions bridging RA and AS, offering valuable insights for future research and clinical management strategies.PMID:38628735 | PMC:PMC11019104 | DOI:10.1016/j.heliyon.2024.e28029 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng Source Type: research
Preclinical models of atherosclerosis: An overview
Iran J Basic Med Sci. 2024;27(5):535-542. doi: 10.22038/IJBMS.2024.74352.16148.ABSTRACTAtherosclerosis is a primary cause of illness and death globally and its mechanism is still unclear. Different animal models have been created to evaluate the progression of atherosclerosis, allowing researchers to carefully control the circumstances of the experiment as well as the nutrition and environmental risk factors. To investigate the negative effects of various interventions, pathophysiological alterations might be generated utilizing genetic or pharmacological methods. These models' molecular and pathophysiological mechanisms h...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Priyanka Arya Vikram Sharma Surabhi Thapliyal Rahul Sagar Priyanka Singh Source Type: research
