Pro-endothelialization of nitinol alloy cardiovascular stents enhanced by the programmed assembly of exosomes and endothelial affinity peptide
In this study, nitinol surfaces with the programmed assembly of heparin, exosomes from endothelial cells, and endothelial affinity peptide (REDV) were fabricated through layer-by-layer assembly technology and click-chemistry, and then exosomes/REDV-modified nitinol interface (ACC-Exo-REDV) was prepared. ACC-Exo-REDV could promote the rapid proliferation and adhesion of endothelial cells and achieve anticoagulant function in the blood. Besides, ACC-Exo-REDV had excellent anti-inflammatory properties and played a positive role in the transformation of macrophage from the pro-inflammatory to anti-inflammatory phenotype. Ex vi...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Linsen Li Yue Yu Xiaoqing Sun Xingyou Wang Xiayan Yang Qifeng Yu Ke Kang Yao Wu Qiangying Yi Source Type: research
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
CONCLUSION: These findings suggest a multiphasic model of aortic wall failure in which primary lesions of intimomedial tears either heal if the media is sufficiently resilient or progress as dissection or rupture by medial delamination and tear completion, respectively. Moreover, mural incorporation of thrombus and cellular responses to injury, two historically important concepts in atheroma pathogenesis, contribute to vessel wall repair with adequate conduit function but even together are not sufficient to induce atherosclerosis.FUNDING: R01-HL146723, R01-HL168473, and Yale Department of Surgery.PMID:38592807 | DOI:10.117...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Abdulrahman Hm Hassab David J Hur Prashanth Vallabhajosyula George Tellides Roland Assi Source Type: research
Residual lipidic risk and atherosclerosis: not that residual
Eur J Prev Cardiol. 2024 Apr 9:zwae134. doi: 10.1093/eurjpc/zwae134. Online ahead of print.NO ABSTRACTPMID:38593199 | DOI:10.1093/eurjpc/zwae134 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Xavier Garcia-Moll Source Type: research
An Inclisiran First Strategy vs Usual Care in Patients with Atherosclerosis
CONCLUSIONS: An "inclisiran first" implementation strategy led to greater LDL-C lowering compared with usual care without discouraging statin use or raising new safety concerns.PMID:38593947 | DOI:10.1016/j.jacc.2024.03.382 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Michael J Koren Fatima Rodriguez Cara East Peter P Toth Veena Watwe Cheryl A Abbas Samiha Sarwat Kelly Kleeman Biswajit Kumar Yousuf Ali Naseem Jaffrani Source Type: research
Pancreatitis risk in genetic subtypes of multifactorial chylomicronemia syndrome
Atherosclerosis. 2024 Mar 26:117528. doi: 10.1016/j.atherosclerosis.2024.117528. Online ahead of print.NO ABSTRACTPMID:38594114 | DOI:10.1016/j.atherosclerosis.2024.117528 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Amanda J Berberich Robert A Hegele Source Type: research
Update on cardiac imaging: A critical analysis
Clin Investig Arterioscler. 2024 Apr 8:S0214-9168(24)00022-6. doi: 10.1016/j.arteri.2024.03.001. Online ahead of print.ABSTRACTImaging is instrumental in diagnosing and directing the management of atherosclerosis. In 1958 the first diagnostic coronary angiography (CA) was performed, and since then further development has led to new methods such as coronary CT angiography (CTA), optical coherence tomography (OCT), positron tomography (PET), and intravascular ultrasound (IVUS). Currently, CA remains powerful for visualizing coronary arteries; however, recent studies show the benefits of using other non-invasive techniques. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Halia Shah Samina Alim Sonia Akther Mahnoor Irfan Jamolbi Rahmatova Aneesa Arshad Charlene Hui Ping Kok Syeda Anum Zahra Source Type: research
Transcriptome exploration of ferroptosis-related genes in TGF β- induced lens epithelial to mesenchymal transition during posterior capsular opacification development
CONCLUSIONS: Our RNA-Seq data identified 38 ferroptosis-related genes in TGF-β2 treated and untreated pLECs, which is the first observation of ferroptosis related genes in primary human lens epithelial cells under TGF-β2 stimulation.PMID:38594623 | DOI:10.1186/s12864-024-10244-y (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Cong Fan Chao Wang Yan Wang Jian Jiang Source Type: research
Cardiovascular Disease Management With Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes: A Cardiology Primer
Tex Heart Inst J. 2024 Apr 9;51(1):e238375. doi: 10.14503/THIJ-23-8375.ABSTRACTPatients with type 2 diabetes face an elevated risk of cardiovascular disease. This review centers on sodium-glucose cotransporter-2 (SGLT2) inhibitors, a class of drugs that, according to a growing body of evidence, may have major potential for managing cardiovascular disease in patients with type 2 diabetes. This review presents findings from multiple clinical trials suggesting that SGLT2 inhibitors can not only serve as preventive therapeutic agents but also play a role in the active management of heart failure. The discussion includes the me...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Allan Zhang Ramsey Kalil Alexander Marzec Stephanie A Coulter Salim Virani Kershaw V Patel Matthew W Segar Source Type: research
Impact of changes in Achilles tendon thickening on cardiovascular events in patients with familial hypercholesterolemia
CONCLUSIONS: Assessing ATT has diagnostic value and allows for risk stratification among patients with HeFH.PMID:38590629 | PMC:PMC10999807 | DOI:10.1016/j.ajpc.2024.100660 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Hayato Tada Nobuko Kojima Yasuaki Takeji Atsushi Nohara Masa-Aki Kawashiri Masayuki Takamura Source Type: research
Association between basal metabolic rate and cardio-metabolic risk factors: Evidence from a Mendelian Randomization study
CONCLUSION: This MR study provides valuable insights into the relationship between BMR and cardio-metabolic risk factors. Understanding the causal links between BMR and these factors could have important implications for the development of targeted interventions and therapies.PMID:38590845 | PMC:PMC10999873 | DOI:10.1016/j.heliyon.2024.e28154 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Limeng Ning Changjing He Chunliu Lu Wanzhong Huang Ting Zeng Qiang Su Source Type: research
Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model
Heliyon. 2024 Mar 25;10(7):e28420. doi: 10.1016/j.heliyon.2024.e28420. eCollection 2024 Apr 15.ABSTRACTOrganoids are 3-dimensional (3D) self-assembled structures capable of replicating the microanatomy and physiology of the epithelial components of their organ of origin. Adult stem cell (ASC) derived organoids from the liver have previously been shown to differentiate into primarily mature cholangiocytes, and their partial differentiation into functional hepatocytes can be promoted using specific media compositions. While full morphological differentiation of mature hepatocytes from ASCs has not yet been reported for any s...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Vojtech Gabriel Addison Lincoln Christopher Zdyrski Abigail Ralston Hannah Wickham Sydney Honold Basant H Ahmed Karel Paukner Ryan Feauto Maria M Merodio Pablo Pi ñeyro David Meyerholz Karin Allenspach Jonathan P Mochel Source Type: research
Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes
CONCLUSION: Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM, especially in the population with younger ages and fewer traditional risk factors.PMID:38591084 | PMC:PMC10999038 | DOI:10.4239/wjd.v15.i3.429 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Fu-Peng Liu Mu-Jie Guo Qing Yang Yan-Ying Li Yan-Gang Wang Mei Zhang Source Type: research
Activation of heme oxygenase-1 by laminar shear stress ameliorates high glucose-induced endothelial cell and smooth muscle cell dysfunction
J Cell Biochem. 2024 Apr 9. doi: 10.1002/jcb.30563. Online ahead of print.ABSTRACTHigh glucose (HG)-induced endothelial cell (EC) and smooth muscle cell (SMC) dysfunction is critical in diabetes-associated atherosclerosis. However, the roles of heme oxygenase-1 (HO-1), a stress-response protein, in hemodynamic force-generated shear stress and HG-induced metabolic stress remain unclear. This investigation examined the cellular effects and mechanisms of HO-1 under physiologically high shear stress (HSS) in HG-treated ECs and adjacent SMCs. We found that exposure of human aortic ECs to HSS significantly increased HO-1 express...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Hung-Che Chien Yu-Lin Wang Yun-Chin Tu Pi-Fen Tsui Min-Chien Tsai Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model
Lab Chip. 2024 Apr 9. doi: 10.1039/d4lc00131a. Online ahead of print.ABSTRACTPlatelets play an essential role in thrombotic processes. Recent studies suggest a direct link between increased plasma glucose, lipids, and inflammatory cytokines with platelet activation and aggregation, resulting in an increased risk of atherothrombotic events in cardiovascular patients. Antiplatelet therapies are commonly used for the primary prevention of atherosclerosis. Transitioning from a population-based strategy to patient-specific care requires a better understanding of the risks and advantages of antiplatelet therapy for individuals. ...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Fahima Akther Hedieh Fallahi Jun Zhang Nam-Trung Nguyen Hang Thu Ta Source Type: research
