How can we improve the prognosis of the patients with homozygous familial hypercholesterolemia?
Familial hypercholesterolemia (FH) is a genetic disease that has high low-density lipoprotein-cholesterol (LDL-C) levels from birth due to mutations in genes related to LDL receptor pathway such as LDLR, PCSK9, APOB and LDLRAP11. Heterozygous FH (HeFH) patients carry the mutated gene in a single allele, having LDL-C levels twice or higher than normal. Having mutations in both alleles, homozygous FH (HoFH) show LDL-C levels twice or higher than HeFH2. Long-lasting hyperLDL-Cemia causes atherosclerotic cardiovascular disease (ASCVD) in FH patients. (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Mariko Harada-Shiba Source Type: research
Impact of optimal cholesterol levels on subclinical atherosclerosis in the absence of risk factors in young adults
CONCLUSIONS: Among adults aged 32-46 years, in the absence of traditional CVRFs, elevated cholesterol levels, even within what is considered optimal, are associated with atherosclerosis and arteriopathy.PMID:38616451 | DOI:10.1016/j.atherosclerosis.2024.117520 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Soroush Masrouri Seyed Saeed Tamehri Zadeh Michael D Shapiro Davood Khalili Farzad Hadaegh Source Type: research
Cardiovascular Risk Factors Among First-Degree Relatives of Patients with Premature Cardiovascular Disease in Malta. Baseline Findings from the CRISO Project
CONCLUSION: This study determined the prevalence of lifestyle, biochemical, physiological, and anthropometric cardiovascular risk factors among asymptomatic first-degree relatives of Maltese patients with premature ASCVD. First-degree relatives had considerable prevalences of an underactive lifestyle, hypertension, and obesity, suggesting better screening and early risk factor intervention are needed to modify their risk of ASCVD.PMID:38616927 | PMC:PMC11015845 | DOI:10.2147/VHRM.S449672 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Justin Lee Mifsud Joseph Galea Source Type: research
Mechanisms underlying TRPV4-mediated regulation of miR-146a expression
bioRxiv [Preprint]. 2024 Apr 3:2024.04.03.587984. doi: 10.1101/2024.04.03.587984.ABSTRACTPersistent inflammation is a major contributor in the development of various inflammatory diseases like atherosclerosis. Our study investigates how transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, interacts with microRNA-146a (miR-146a), within the context of inflammation and atherosclerosis. Micro-RNAs play a critical role in controlling gene expression, and miR-146a is notable for its anti-inflammatory actions. TRPV4 is activated by diverse soluble and mechanical stimuli, and often associated with inf...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Bidisha Dutta Manisha Mahanty Lakshmyya Kesavalu Shaik O Rahaman Source Type: research
PVDF/ZnO piezoelectric nanofibers designed for monitoring of internal micro-pressure
In this study, we present a breakthrough in the fabrication of soft poly(vinylidene fluoride) (PVDF) organic electrospun piezoelectric nanofibers (OEPNs) with exceptional piezoelectric performance achieved through the incorporation of zinc oxide nanorods (ZnO NR). The inclusion of ZnO NR proved instrumental in augmenting the nanocrystallization of PVDF organic electrospun piezoelectric nanofibers (OEPNs), leading to a highly efficient crystal phase transformation from the α phase to the β/γ phase, serving as superior piezoelectric working dipoles. The resulting PVDF/ZnO NR OEPNs exhibited unparalleled piezoelectric outp...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Geng Chang Xuchao Pan Yu Hao Wei Du Siwei Wang Yu Zhou Jie Yang Yong He Source Type: research
Glucagon-like Peptide-1 analogues and delipidation of coronary atheroma in statin-treated type 2 diabetic patients with coronary artery disease: The prespecified sub-analysis of the OPTIMAL randomized clinical trial
CONCLUSIONS: In statin-treated patients with T2D and CAD, GLP-1RAs produced favourable changes in lipidic plaque materials, consistent with its stabilization.PMID:38617596 | PMC:PMC11015340 | DOI:10.1016/j.athplu.2024.03.001 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Yu Kataoka Satoshi Kitahara Sayaka Funabashi Hisashi Makino Masaki Matsubara Miki Matsuo Yoko Omura-Ohata Ryo Koezuka Mayu Tochiya Tamiko Tamanaha Tsutomu Tomita Kyoko Honda-Kohmo Michio Noguchi Kota Murai Kenichiro Sawada Takamasa Iwai Hideo Matama Satos Source Type: research
Visualization of Borderline Coronary Artery Lesions by CT Angiography and Coronary Artery Disease Reporting and Data System
J Korean Soc Radiol. 2024 Mar;85(2):297-307. doi: 10.3348/jksr.2023.0141. Epub 2024 Mar 27.ABSTRACTCoronary artery disease (CAD) narrows vessel lumens at the sites of atherosclerosis, increasing the risk of myocardial ischemia or infarction. Early and accurate diagnosis of CAD is crucial to significantly improve prognosis and management. CT angiography (CTA) is a noninvasive imaging technique that enables assessment of vascular structure and stenosis with high resolution and contrast. Coronary CTA is useful in the diagnosis of CAD. Recently, the CAD-reporting and data system (CAD-RADS), a diagnostic classification system b...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Hyewon Park Yu-Whan Oh Ki Yeol Lee Hwan Seok Yong Cherry Kim Sung Ho Hwang Source Type: research
Development of a Rabbit Iliac Arterial Stenosis Model Using a Controlled Cholesterol Diet and Pullover Balloon Injury
CONCLUSION: Pullover-balloon injury can lead to significant iliac artery stenosis in rabbits with controlled hypercholesterolemia. This model may be useful for elucidating the pathogenesis of atherosclerosis and for evaluating the efficacy of novel therapeutic interventions.PMID:38617867 | PMC:PMC11009124 | DOI:10.3348/jksr.2023.0106 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Hooney D Min Chong-Ho Lee Jae Hwan Lee Kun Yung Kim Chang Jin Yoon Minuk Kim Source Type: research
A Chinese classical prescription Xuefu Zhuyu decoction in the treatment of coronary heart disease: An overview
CONCLUSION: Through this study, we found that XFZYD has a significant therapeutic effect in the clinical treatment of coronary heart disease, which can play a role in the treatment of CHD by inhibiting atherosclerosis, inhibiting cardiovascular remodeling, improving oxidative stress damage, improving hemorheology, improving myocardial fibrosis and other mechanisms. Through computer simulation, it was found that the main effective components of XFZYD treatment for CHD were quercetin, kaempferol and luteolin, and the key core targets were IL6, VEGFA and P53, and each component had a high VEGFA libdock score. It is speculated...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Xuezhen Wang Xunyan Xing Peifeng Huang Zhibin Zhang Zehua Zhou Leiqin Liang Rongmei Yao Xuerun Wu Long Yang Source Type: research
Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms
In this report, we discuss how EC-IC bypass turned out to be beneficial for a patient presenting with blood pressure-dependent severe aphasia and right hemiparesis due to middle cerebral artery (MCA) occlusion that failed thrombectomy. CT perfusion (CTP) scan at admission demonstrated a persistent volume of delayed perfusion without core infarct. Following the superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass, the patient's National Institute of Health Stroke Scale (NIHSS) score improved from 12 to 1. Ischemic penumbra, as seen on CTP imaging, also improved after the STA-MCA bypass. Our case suggests t...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Brendan Huang Calvin Huang Khaled Alok Alex Y Chen Source Type: research
Left Upper Extremity Pain, Right Coronary Artery Culprit: A Puzzling Path to Aneurysm Discovery
We report a case of an adult harboring a GCA involving the right coronary artery.PMID:38618608 | PMC:PMC11011955 | DOI:10.14797/mdcvj.1287 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Moath Said Alfawara Vivek Modi Min-Fang Chao Malek Nayfeh Fares Alahdab Mahmoud Alrifai Mouaz Al-Mallah Source Type: research
The vascular footprint in cardiac homeostasis and hypertensive heart disease-A link between apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase
Anat Rec (Hoboken). 2024 Apr 15. doi: 10.1002/ar.25453. Online ahead of print.ABSTRACTRecent studies have suggested a connection between disturbances of the apelin system and various cardiac pathologies, including hypertension, heart failure, and atherosclerosis. Vascular endothelial growth factor is crucial for cardiac homeostasis as a critical molecule in cardiac angiogenesis. Neuronal nitric oxide synthase is an essential enzyme producing nitric oxide, a key regulator of vascular tone. The present study aims to shed light upon the complex interactions between these three vital signaling molecules and examine their chang...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Alexandar Iliev Lyubomir Gaydarski Georgi Kotov Boycho Landzhov Vidin Kirkov Stancho Stanchev Source Type: research
Exploring the mechanism of levocarnitine in the treatment of epididymitis based on network pharmacology and molecular docking technology
CONCLUSION: This study revealed through network pharmacology that levocarnitine may act on multiple signaling pathways by targeting AKT1, HSP90AA1, ALB, CASP3, GSK3B, GSR, etc., thereby potentially exerting therapeutic effects on epididymitis.PMID:38619515 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Ming-Wei Zhan Lei Wang Xu-Xin Zhan Peng-Fei Liu Qiang Lou Yu-Qi Lai Yi Yu Xue-Jun Shang Source Type: research
Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation
CONCLUSION: The establishment of RI provides a reference for diseases related to platelet activation and the use of drugs, and the first discovery of the correlation between 11dhTxB2 and 11dh23dinorTxB2 in urine provides a new possibilitie for the diagnostic and prognostic of cardiovascular diseases.PMID:38621589 | DOI:10.1016/j.cca.2024.119672 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Yunfeng Cao Furong Zhao Shuang Wang Ying Li Shuainan Li Xueting Cui Source Type: research
CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation
CONCLUSION: CircHIPK3 interact with DRP1 involve in H2O2 induced Mitochondrial damage and necroptosis of VSMCs, and Silencing circHIPK3 in vivo can reduce atherosclerotic vulnerable plaque formation. Our research findings may have applications in providing diagnostic biomarkers for vulnerable plaques.PMID:38621622 | DOI:10.1016/j.jare.2024.04.011 (Source: Atherosclerosis)
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Xiaolu Li Yanyan Yang Zhibin Wang Xiaotong Lin Xiuxiu Fu Xiangqin He Meixin Liu Jian-Xun Wang Tao Yu Pin Sun Source Type: research
