Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Facilitates Foam Cell Formation and Atherosclerosis Progression Through the miR-17-5p/Itchy E3 Ubiquitin Protein Ligase (ITCH)/Liver Kinase B1 (LKB1) Axis
CONCLUSIONS: NEAT1 accelerated foam cell formation during AS progression through the miR-17-5p/ITCH/LKB1 axis.PMID:38631864 | DOI:10.1253/circj.CJ-23-0769 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Haifen Huang Bin Peng Qingyong Chen Yi Wang Ren Li Source Type: research
From a dirty breath to atherosclerosis: Ozone pollution and neutrophil extracellular traps (NETs)
Exposure to ambient ozone in healthy individuals (shown in the magnified alveolus, including the transfer of ozone via the alveolar-capillary membrane and the contact with circulating neutrophils) associates with an elevation in the pro-atherogenic immunothrombotic pathway of NETosis. Precise mechanisms, and the role of concomitant pollutants remain unknown. Abbreviations: particulate matter (PM), ultrafine particles (UFP), sulphur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), neutrophil extracellular traps (NETs), and red blood cells (RBC). (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Tyler Artner, Irene M. Lang Source Type: research
DEep LearnIng-based QuaNtification of Epicardial Adipose Tissue predicts MACE in patients undergoing stress CMR
This study investigated the additional prognostic value of epicardial adipose tissue (EAT) volume for major adverse cardiovascular events (MACE) in patients undergoing stress cardiac magnetic resonance (CMR) imaging. (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Marco Guglielmo, Marco Penso, Maria Ludovica Carerj, Carlo Maria Giacari, Alessandra Volpe, Laura Fusini, Andrea Baggiano, Saima Mushtaq, Andrea Annoni, Francesco Cannata, Francesco Cilia, Alberico Del Torto, Fabio Fazzari, Alberto Formenti, Antonio Frapp Source Type: research
Impact of loss-of-function in angiopoietin-like 4 on the human phenome
Carriers of the E40K loss-of-function variant in Angiopoietin-like 4 (ANGPTL4), have lower plasma triglyceride levels as well as lower rates of coronary artery disease (CAD) and type 2 diabetes (T2D). These genetic data suggest ANGPTL4 inhibition as a potential therapeutic target for cardiometabolic diseases. However, it is unknown whether the association between E40K and human diseases is due to linkage disequilibrium confounding. The broader impact of genetic ANGPTL4 inhibition is also unknown, raising uncertainties about the safety and validity of this target. (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Eloi Gagnon, J érome Bourgault, Émilie Gobeil, Sébastien Thériault, Benoit J. Arsenault Source Type: research
Novel cutting edge nano-strategies to address old long-standing complications in cardiovascular diseases. A comprehensive review
CONCLUSION: Here, we present a comprehensive overview of the recent advancements in targeted nanoparticle approaches for diagnosing CVDs, encompassing molecular imaging techniques, underscoring the significant progress in theranostic, as a novel and promising therapeutic strategy.PMID:38622800 | DOI:10.1111/eci.14208 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Laura Tesoro Ignacio Hernandez Marta Saura Lina Badim ón Carlos Zaragoza Source Type: research
Associations between the retinal/choroidal microvasculature and carotid plaque in patients with CAD: An OCTA study
CONCLUSIONS: In patients with CAD, carotid plaque, a risk factor and marker of atherosclerosis and stenosis, is significantly and independently associated with retinal and choroidal microvascular changes by OCTA.PMID:38623223 | PMC:PMC11016606 | DOI:10.1016/j.heliyon.2024.e29107 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Jing Jiang Jin Wang Yucen Wang Luoziyi Wang Yiwen Qian Zhiliang Wang Source Type: research
Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis
This study investigates the impact of endothelial cell (EC)-specific partial loss of Pfn1 expression in atherosclerosis development. We utilized mice engineered for conditional heterozygous knockout of the Pfn1 gene in ECs, with atherosclerosis induced by depletion of hepatic LDL receptor by gene delivery of PCSK9 combined with high-cholesterol diet. Our studies show that partial depletion of EC Pfn1 has certain beneficial effects marked by dampening of select pro-atherogenic cytokines (CXCL10 and IL7) with concomitant reduction in cytotoxic T cell abundance but is not sufficient to reduce hyperlipidemia and confer atherop...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Abigail Allen-Gondringer David Gau Partha Dutta Partha Roy Source Type: research
The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-05000-5. Online ahead of print.ABSTRACTMechanosensitive ion channels are widely distributed in the heart, lung, bladder and other tissues, and plays an important role in exercise-induced cardiovascular function promotion. By reviewing the PubMed databases, the results were summarized using the terms "Exercise/Sport", "Piezo1", "Transient receptor potential (TRP)" and "Cardiovascular" as the keywords, 124-related papers screened were sorted and reviewed. The results showed that: (1) Piezo1 and TRP channels play an important role in regulating blood pressure and the deve...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Xinyan Duan Renhan Liu Yue Xi Zhenjun Tian Source Type: research
Endothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia
This study aims to investigate the effects of rs213045 and rs2038089 polymorphisms in the ECE-1 gene which have been previously shown to be associated with atherosclerosis and hypertension (HT), in CAE patients. Ninety-six CAE and 175 patients with normal coronary arteries were included in the study. ECE-1b gene variations rs213045 and rs2038089 were determined by real-time PCR. The frequencies of rs213045 C > A (C338A) CC genotype (60.4% vs. 35.4%, p < 0.001) and rs2038089 T > C T allele (64.58% vs. 35.42%, p = 0.017) were higher in the CAE group compared to the control group. The multivariate regression analysis...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Gulcin Ozkara Ezgi Irmak Aslan Fidan Malikova Cagatay Aydogan Ozgur Selim Ser Onur Kilicarslan Sadiye Nur Dalgic Ahmet Yildiz Oguz Ozturk Hulya Yilmaz-Aydogan Source Type: research
Association between atherogenic indexes and erectile dysfunction: a cross-sectional analysis of the National Health and Nutrition Examination Survey 2001-2004
CONCLUSIONS: AIP is positively associated with the development of ED in US adults. More prospective cohort studies are needed to confirm the link between AIP and ED.PMID:38625648 | DOI:10.1007/s11255-024-04050-4 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Lange Guo Yukui Nan Lizhong Yao Source Type: research
Endothelial NLRP3 inflammasome regulation in atherosclerosis
CONCLUSIONS: Our findings highlight the existence of a glycolysis-dependent NADH/CtBP/FOXP1-transrepression pathway that regulates endothelial NLRP3 inflammasome activation in atherogenesis. This pathway represents a potential target for selective PFKFB3 inhibitors or strategies aimed at disrupting CtBP1 oligomerization to modulate atherosclerosis.PMID:38626254 | DOI:10.1093/cvr/cvae071 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Shuai Guo Litao Wang Kaixiang Cao Ziling Li Mingchuan Song Shuqi Huang Zou Li Cailing Wang Peiling Chen Yong Wang Xiaoyan Dai Xianglin Chen Xiaodong Fu Du Feng Jun He Yuqing Huo Yiming Xu Source Type: research
MicroRNA-155 and exosomal microRNA-155: Small pieces in the cardiovascular diseases puzzle
Pathol Res Pract. 2024 Apr 1;257:155274. doi: 10.1016/j.prp.2024.155274. Online ahead of print.ABSTRACTMicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend ...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Reza Eshraghi Moein Rafiei Zahra Hadian Jazi Davood Shafie Arash Raisi Hamed Mirzaei Source Type: research
The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
Conclusions Our data suggest that combination therapy with liraglutide and ipragliflozin may be an efficient regimen for preventing the development of atherosclerosis in diabetic ApoE-deficient mice.PMID:38626913 | DOI:10.1055/a-2307-8036 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Masahiro Takubo Kentaro Watanabe Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research
Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction
CONCLUSION: Our study demonstrated a significant association between TAC and CAC scores but a superior prognostic value of CAC score for ASCVD events. These findings suggest TAC on chest CT provides supplementary data to estimate ASCVD risk but does not replace CAC on ECG-gated cardiac CT.PMID:38627022 | DOI:10.1136/heartjnl-2023-323838 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Keishi Ichikawa Wang Rui Robyn L McClelland Venkat S Manubolu Shriraj Susarla Duo Lee Leili Pourafkari Hooman Fazlalizadeh Jairo Aldana Bitar Rick Robin April Kinninger Sion Roy Wendy S Post Matthew Budoff Source Type: research
