Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPAR γ

CONCLUSIONS: Collectively, this evidence reveals an important role of TRAF5 in the development of intimal hyperplasia through the regulation of macrophage polarization, which provides a promising target for arterial restenosis-related disease management.PMID:38642079 | DOI:10.1007/s00011-024-01875-8

Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Wen-Lin Cheng Sheng-Ping Chao Fang Zhao Huan-Huan Cai Ziyue Zeng Jian-Lei Cao Zhili Jin Ke-Qiong Deng Xiaorong Hu Hairong Wang Zhibing Lu Source Type: research