Limb Outcomes With Ticagrelor Plus Aspirin in Patients With Diabetes Mellitus and Atherosclerosis

CONCLUSIONS: Patients with T2DM and atherosclerosis are at high risk of limb events. Ticagrelor decreased this risk, but increased bleeding. Future trials evaluating the combination of ticagrelor and aspirin would further elucidate the benefit/risk of such therapy in patients with PAD, including those without coronary artery disease. (A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus [THEMIS]: NCT01991795).PMID:38658101 | DOI:10.1016/j.jacc.2024.03.377

Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Marc P Bonaca Deepak L Bhatt Tabassome Simon Kim Michael Fox Shamir Mehta Robert A Harrington Lawrence A Leiter Warren H Capell Claes Held Anders Himmelmann Wilhelm Ridderstr åle Jersey Chen Jane J Lee Yang Song Marielle Andersson Jayne Prats Mikhail Kos Source Type: research