Geiser Sign in a patient with rheumatoid arthritis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 4, 2024 Category: Rheumatology Source Type: research
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2
In this study, we constructed a collagen-induced arthritis (CIA) model in rats. We used MSCs-exo combined with Rh2 to treat CIA rats. To observe the effect of MSCs-exo combined with Rh2 on joint inflammation, rat feces were collected for 16 rRNA amplicon sequencing and untargeted metabolomics analysis. The results showed that the arthritis index score and joint swelling of CIA rats treated with MSCs-exo in combination with Rh2 were significantly lower than those of the model and MSCs-exo alone groups. MSCs-exo and Rh2 significantly ameliorated the disturbed gut microbiota in CIA rats. The regulation of Candidatus_Saccharib...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2024 Category: Drugs & Pharmacology Authors: Zhongsheng Zhou Yang Li Shuhui Wu Te Liu Jinlan Jiang Source Type: research
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2
In this study, we constructed a collagen-induced arthritis (CIA) model in rats. We used MSCs-exo combined with Rh2 to treat CIA rats. To observe the effect of MSCs-exo combined with Rh2 on joint inflammation, rat feces were collected for 16 rRNA amplicon sequencing and untargeted metabolomics analysis. The results showed that the arthritis index score and joint swelling of CIA rats treated with MSCs-exo in combination with Rh2 were significantly lower than those of the model and MSCs-exo alone groups. MSCs-exo and Rh2 significantly ameliorated the disturbed gut microbiota in CIA rats. The regulation of Candidatus_Saccharib...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2024 Category: Drugs & Pharmacology Authors: Zhongsheng Zhou Yang Li Shuhui Wu Te Liu Jinlan Jiang Source Type: research
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research
Dysregulated NUB1 and neddylation enhances rheumatoid arthritis fibroblast ‐like synoviocyte inflammatory responses
ConclusionCUL1 neddylation andNUB1 induction is dysregulated in RA, which increases FLS activation. Inhibition of neddylation is an effective therapy in an animal model of arthritis. These data suggest that neddylation system contributes to the pathogenesis of RA and that regulation of neddylation could be a novel therapeutic approach. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Sho Sendo,
Camilla R. L. Machado,
David L Boyle,
Robert J. Benschop,
Narayanan B. Perumal,
Eunice Choi,
Wei Wang,
Gary S Firestein Tags: Full Length Source Type: research
Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review
AbstractInflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioration, exudation, and proliferation of local tissues, which can cause systemic damage in severe cases. Inflammatory lesions are primarily localized but may interact with body systems to cause provocative storms, parenchymal organ lesions, vascular and central nervous system necrosis, and other pathologic responses. Tetrandrine (TET) is a bisbenzylquinoline alkaloid extracted from the traditional Chinese herbal medicineStephania tetrandra, which has been shown to have significant efficacy in inflamma...
Source: Inflammopharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Updates in Ultrasound in Rheumatology
Conclusions: In rheumatology's dynamic landscape, this review provides valuable insights for researchers and clinicians on ultrasound's role in improving patient care and outcomes in rheumatic diseases. (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - April 3, 2024 Category: Radiology Authors: Georgios Filippou, Maria Elena Pellegrino, Adriana Sorce, Silvia Sirotti, Matteo Ferrito, Salvatore Gitto, Carmelo Messina, Domenico Albano, Luca Maria Sconfienza Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
CONCLUSION: There was no evidence for a difference between the two groups in terms of discontinuation rates, efficacy, and safety. To provide further evidence, future studies using more precise dose-escalation protocols are warranted.PMID:38563202 | DOI:10.1080/03009742.2024.2327159 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 2, 2024 Category: Rheumatology Authors: M Ayano K Tsubouchi K Suzuki Y Kimoto Y Arinobu K Akashi T Horiuchi I Okamoto H Niiro Source Type: research
