An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
Dual Drug Nanoparticle Synergistically Induced Apoptosis, Suppressed Inflammation and Protected Autophagic Response in Rheumatoid Arthritis Fibroblast-like Synoviocytes
In this study, we assessed the therapeutic effectiveness of DD NP HG in primary RA-FLS cells isolated from the synovial tissue of FCA-induced RA rats. We observed that DD NP HG had good biosafety for healthy FLS cells and, at higher concentrations, a mild inhibitory effect on RA-FLS. The combination therapy (DD NP HG) of MTX NP and PEITC NE in RA-FLS showed a higher rate of apoptosis with significantly reduced LPS-induced expression of pro-inflammatory cytokines (TNF-α, IL-17A, and IL-6) in arthritic FLSs. Further, the gene expression studies showed that DD NP HG significantly down-regulated the mRNA expression of IL-1β,...
Source: Immunology Letters - March 27, 2024 Category: Allergy & Immunology Authors: Prakash Haloi Rajat Choudhary B Siva Lokesh V Badireenath Konkimalla Source Type: research
The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs
CONCLUSION: The gut microbiota, memory Tfh cells, memory B cells, and cytokines of patients with RA changed significantly under different treatment regimens and had certain correlations with the clinical indicators of RA.PMID:38537424 | DOI:10.1016/j.imbio.2024.152798 (Source: Immunobiology)
Source: Immunobiology - March 27, 2024 Category: Allergy & Immunology Authors: Chunlei Jiang Shuhong Chi Fengkui Wang Chenyang Zhao Xiaojuan Yang Miao Liu Bin Ma Jian Chen Chunxia Su Xiangguo Duan Source Type: research
An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
Dual Drug Nanoparticle Synergistically Induced Apoptosis, Suppressed Inflammation and Protected Autophagic Response in Rheumatoid Arthritis Fibroblast-like Synoviocytes
In this study, we assessed the therapeutic effectiveness of DD NP HG in primary RA-FLS cells isolated from the synovial tissue of FCA-induced RA rats. We observed that DD NP HG had good biosafety for healthy FLS cells and, at higher concentrations, a mild inhibitory effect on RA-FLS. The combination therapy (DD NP HG) of MTX NP and PEITC NE in RA-FLS showed a higher rate of apoptosis with significantly reduced LPS-induced expression of pro-inflammatory cytokines (TNF-α, IL-17A, and IL-6) in arthritic FLSs. Further, the gene expression studies showed that DD NP HG significantly down-regulated the mRNA expression of IL-1β,...
Source: Immunology Letters - March 27, 2024 Category: Allergy & Immunology Authors: Prakash Haloi Rajat Choudhary B Siva Lokesh V Badireenath Konkimalla Source Type: research
The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs
CONCLUSION: The gut microbiota, memory Tfh cells, memory B cells, and cytokines of patients with RA changed significantly under different treatment regimens and had certain correlations with the clinical indicators of RA.PMID:38537424 | DOI:10.1016/j.imbio.2024.152798 (Source: Immunobiology)
Source: Immunobiology - March 27, 2024 Category: Allergy & Immunology Authors: Chunlei Jiang Shuhong Chi Fengkui Wang Chenyang Zhao Xiaojuan Yang Miao Liu Bin Ma Jian Chen Chunxia Su Xiangguo Duan Source Type: research
An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
Dual Drug Nanoparticle Synergistically Induced Apoptosis, Suppressed Inflammation and Protected Autophagic Response in Rheumatoid Arthritis Fibroblast-like Synoviocytes
In this study, we assessed the therapeutic effectiveness of DD NP HG in primary RA-FLS cells isolated from the synovial tissue of FCA-induced RA rats. We observed that DD NP HG had good biosafety for healthy FLS cells and, at higher concentrations, a mild inhibitory effect on RA-FLS. The combination therapy (DD NP HG) of MTX NP and PEITC NE in RA-FLS showed a higher rate of apoptosis with significantly reduced LPS-induced expression of pro-inflammatory cytokines (TNF-α, IL-17A, and IL-6) in arthritic FLSs. Further, the gene expression studies showed that DD NP HG significantly down-regulated the mRNA expression of IL-1β,...
Source: Immunology Letters - March 27, 2024 Category: Allergy & Immunology Authors: Prakash Haloi Rajat Choudhary B Siva Lokesh V Badireenath Konkimalla Source Type: research
The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs
CONCLUSION: The gut microbiota, memory Tfh cells, memory B cells, and cytokines of patients with RA changed significantly under different treatment regimens and had certain correlations with the clinical indicators of RA.PMID:38537424 | DOI:10.1016/j.imbio.2024.152798 (Source: Immunobiology)
Source: Immunobiology - March 27, 2024 Category: Allergy & Immunology Authors: Chunlei Jiang Shuhong Chi Fengkui Wang Chenyang Zhao Xiaojuan Yang Miao Liu Bin Ma Jian Chen Chunxia Su Xiangguo Duan Source Type: research
An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
Dual drug nanoparticle synergistically induced apoptosis, suppressed inflammation, and protected autophagic response in rheumatoid arthritis fibroblast-like synoviocytes
In this study, we assessed the therapeutic effectiveness of DD NP HG in primary RA-FLS cells isolated from the synovial tissue of FCA-induced RA rats. We observed that DD NP HG had good biosafety for healthy FLS cells and, at higher concentrations, a mild inhibitory effect on RA-FLS. The combination therapy (DD NP HG) of MTX NP and PEITC NE in RA-FLS showed a higher rate of apoptosis with significantly reduced LPS-induced expression of pro-inflammatory cytokines (TNF-α, IL-17A, and IL-6) in arthritic FLS. Further, the gene expression studies showed that DD NP HG significantly down-regulated the mRNA expression of IL-1β, ...
Source: Immunology Letters - March 27, 2024 Category: Allergy & Immunology Authors: Prakash Haloi Rajat Choudhary B Siva Lokesh V Badireenath Konkimalla Source Type: research
The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs
CONCLUSION: The gut microbiota, memory Tfh cells, memory B cells, and cytokines of patients with RA changed significantly under different treatment regimens and had certain correlations with the clinical indicators of RA.PMID:38537424 | DOI:10.1016/j.imbio.2024.152798 (Source: Immunobiology)
Source: Immunobiology - March 27, 2024 Category: Allergy & Immunology Authors: Chunlei Jiang Shuhong Chi Fengkui Wang Chenyang Zhao Xiaojuan Yang Miao Liu Bin Ma Jian Chen Chunxia Su Xiangguo Duan Source Type: research
An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
Dual drug nanoparticle synergistically induced apoptosis, suppressed inflammation, and protected autophagic response in rheumatoid arthritis fibroblast-like synoviocytes
In this study, we assessed the therapeutic effectiveness of DD NP HG in primary RA-FLS cells isolated from the synovial tissue of FCA-induced RA rats. We observed that DD NP HG had good biosafety for healthy FLS cells and, at higher concentrations, a mild inhibitory effect on RA-FLS. The combination therapy (DD NP HG) of MTX NP and PEITC NE in RA-FLS showed a higher rate of apoptosis with significantly reduced LPS-induced expression of pro-inflammatory cytokines (TNF-α, IL-17A, and IL-6) in arthritic FLS. Further, the gene expression studies showed that DD NP HG significantly down-regulated the mRNA expression of IL-1β, ...
Source: Immunology Letters - March 27, 2024 Category: Allergy & Immunology Authors: Prakash Haloi Rajat Choudhary B Siva Lokesh V Badireenath Konkimalla Source Type: research
An Elevated < em > IL10 < /em > mRNA Combined with Lower < em > TNFA < /em > mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research
