Exploring the Mechanism of Acupuncture's Influence on the Protease Activity and Free Radical Damage in Synovial Fluid of Rheumatoid Arthritis Rats Induced by Type II Collagen from the Release of Active Oxygen
Appl Biochem Biotechnol. 2024 Mar 28. doi: 10.1007/s12010-024-04932-4. Online ahead of print.ABSTRACTAcupuncture was studied to investigate the mechanism of its effect on protease vitality and free radical damage in Type I CIA rats induced by type II collagen. The study divided rats into a control group (injected with physiological saline, n = 10), a model group (injected with type II collagen, n = 10), and an intervention group (injected with type II collagen + acupuncture ST36 and GB39, 3 times a week, for a total of 4 weeks, n = 10) based on the different injected drugs. Then, various indicators of the mice were experim...
Source: Applied Biochemistry and Biotechnology - March 28, 2024 Category: Biochemistry Authors: Kaiying Cui Dezhong Bi Fuyan Wang Pengfei Hou Jinxing Guo Zhanwang Xu Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
Peficitinib alleviated acute lung injury by blocking glycolysis through JAK3/STAT3 pathway
Int Immunopharmacol. 2024 Mar 27;132:111931. doi: 10.1016/j.intimp.2024.111931. Online ahead of print.ABSTRACTPeficitinib is a selective Janus kinase (JAK3) inhibitor recently developed and approved for the treatment of rheumatoid arthritis in Japan. Glycolysis in macrophages could induce NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation, thus resulting in pyroptosis and acute lung injury (ALI). The aim of our study was to investigate whether Peficitinib could alleviate lipopolysaccharide (LPS)-induced ALI by inhibiting NLRP3 inflammasome activation. Wild type C57BL/6J mic...
Source: International Immunopharmacology - March 28, 2024 Category: Allergy & Immunology Authors: Wenyang Jiang Jie Ren Xiaochen Li Jianjian Yang Dan Cheng Source Type: research
The prevalence and risk factors of rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis
CONCLUSION(S): The pooled prevalence of RA-ILD in our study was approximately 18.7%. Furthermore, we identified 13 risk factors for RA-ILD, including male sex, older age, having a smoking history, pulmonary comorbidities, older age of RA onset, longer RA duration, positive RF, positive ACPA, higher ESR, moderate and high DAS28 (≥3.2), rheumatoid nodules, LEF use and steroid use. Additionally, biological agents use was a protective factor.PMID:38547537 | DOI:10.1080/07853890.2024.2332406 (Source: Annals of Medicine)
Source: Annals of Medicine - March 28, 2024 Category: Internal Medicine Authors: Hong-Fei Wang Yan-Yun Wang Zhi-Yu Li Pei-Jie He Shan Liu Qiu-Shuang Li Source Type: research
Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology
Int J Mol Sci. 2024 Mar 18;25(6):3429. doi: 10.3390/ijms25063429.ABSTRACTCardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Di ána Simon Dorottya Kacs ándi Anita Pusztai Bogl árka Soós Edit V égh Gy örgy Kerekes Monika Bodoki Szilvia Szamosi Gabriella Sz űcs Zolt án Prohászka P éter Németh T ímea Berki Zolt án Szekanecz Source Type: research
Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate
CONCLUSION: The developed SNP-DMAP-MTX has been proven to deliver MTX transdermal and selectively at the RA site, potentially avoiding conventional MTX side effects and enhancing the effectiveness of RA therapy.PMID:38538953 | DOI:10.1208/s12249-024-02777-y (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 28, 2024 Category: Drugs & Pharmacology Authors: Nur Qadri Febrianti Anugerah Yaumil Ramadhani Aziz Muhamad Gilang Ramadhan Tunggeng Indianty Dwi Ramadhany Nur Syafika Sumayya Binti Abd Azis Yulia Yusrini Djabir Rangga Meidianto Asri Andi Dian Permana Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Exploring the Mechanism of Acupuncture's Influence on the Protease Activity and Free Radical Damage in Synovial Fluid of Rheumatoid Arthritis Rats Induced by Type II Collagen from the Release of Active Oxygen
Appl Biochem Biotechnol. 2024 Mar 28. doi: 10.1007/s12010-024-04932-4. Online ahead of print.ABSTRACTAcupuncture was studied to investigate the mechanism of its effect on protease vitality and free radical damage in Type I CIA rats induced by type II collagen. The study divided rats into a control group (injected with physiological saline, n = 10), a model group (injected with type II collagen, n = 10), and an intervention group (injected with type II collagen + acupuncture ST36 and GB39, 3 times a week, for a total of 4 weeks, n = 10) based on the different injected drugs. Then, various indicators of the mice were experim...
Source: Applied Biochemistry and Biotechnology - March 28, 2024 Category: Biochemistry Authors: Kaiying Cui Dezhong Bi Fuyan Wang Pengfei Hou Jinxing Guo Zhanwang Xu Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
The prevalence and risk factors of rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis
CONCLUSION(S): The pooled prevalence of RA-ILD in our study was approximately 18.7%. Furthermore, we identified 13 risk factors for RA-ILD, including male sex, older age, having a smoking history, pulmonary comorbidities, older age of RA onset, longer RA duration, positive RF, positive ACPA, higher ESR, moderate and high DAS28 (≥3.2), rheumatoid nodules, LEF use and steroid use. Additionally, biological agents use was a protective factor.PMID:38547537 | DOI:10.1080/07853890.2024.2332406 (Source: Annals of Medicine)
Source: Annals of Medicine - March 28, 2024 Category: Internal Medicine Authors: Hong-Fei Wang Yan-Yun Wang Zhi-Yu Li Pei-Jie He Shan Liu Qiu-Shuang Li Source Type: research
Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate
CONCLUSION: The developed SNP-DMAP-MTX has been proven to deliver MTX transdermal and selectively at the RA site, potentially avoiding conventional MTX side effects and enhancing the effectiveness of RA therapy.PMID:38538953 | DOI:10.1208/s12249-024-02777-y (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 28, 2024 Category: Drugs & Pharmacology Authors: Nur Qadri Febrianti Anugerah Yaumil Ramadhani Aziz Muhamad Gilang Ramadhan Tunggeng Indianty Dwi Ramadhany Nur Syafika Sumayya Binti Abd Azis Yulia Yusrini Djabir Rangga Meidianto Asri Andi Dian Permana Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Exploring the Mechanism of Acupuncture's Influence on the Protease Activity and Free Radical Damage in Synovial Fluid of Rheumatoid Arthritis Rats Induced by Type II Collagen from the Release of Active Oxygen
Appl Biochem Biotechnol. 2024 Mar 28. doi: 10.1007/s12010-024-04932-4. Online ahead of print.ABSTRACTAcupuncture was studied to investigate the mechanism of its effect on protease vitality and free radical damage in Type I CIA rats induced by type II collagen. The study divided rats into a control group (injected with physiological saline, n = 10), a model group (injected with type II collagen, n = 10), and an intervention group (injected with type II collagen + acupuncture ST36 and GB39, 3 times a week, for a total of 4 weeks, n = 10) based on the different injected drugs. Then, various indicators of the mice were experim...
Source: Applied Biochemistry and Biotechnology - March 28, 2024 Category: Biochemistry Authors: Kaiying Cui Dezhong Bi Fuyan Wang Pengfei Hou Jinxing Guo Zhanwang Xu Source Type: research
The prevalence and risk factors of rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis
CONCLUSION(S): The pooled prevalence of RA-ILD in our study was approximately 18.7%. Furthermore, we identified 13 risk factors for RA-ILD, including male sex, older age, having a smoking history, pulmonary comorbidities, older age of RA onset, longer RA duration, positive RF, positive ACPA, higher ESR, moderate and high DAS28 (≥3.2), rheumatoid nodules, LEF use and steroid use. Additionally, biological agents use was a protective factor.PMID:38547537 | PMC:PMC10984230 | DOI:10.1080/07853890.2024.2332406 (Source: Annals of Medicine)
Source: Annals of Medicine - March 28, 2024 Category: Internal Medicine Authors: Hong-Fei Wang Yan-Yun Wang Zhi-Yu Li Pei-Jie He Shan Liu Qiu-Shuang Li Source Type: research
