Prevalence of remission in patients with rheumatoid arthritis in daily clinical practice: long-term data from a tertiary care centre
CONCLUSIONS: Most patients achieved remission at least once within the observation period and almost 50% of patients also achieved SR. This study shows that the target of achieving remission should be constantly pursued, as we were able to show that even in the fourth year of treatment, patients still achieved remission.PMID:38530668 | DOI:10.55563/clinexprheumatol/66rnqb (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 26, 2024 Category: Rheumatology Authors: Nils Gildemeister Imke Redeker Bjoern Buehring Ioana Andreica David Kiefer Xenofon Baraliakos Juergen Braun Uta Kiltz Source Type: research
Factors associated of long-term retention rate of Janus kinase inhibitors in a multi-failure rheumatoid arthritis population
CONCLUSIONS: In conclusion, our study supports the clinical effectiveness of JAKi in RA, even in the multi-failure subgroup of patients, where the risk/benefit ratio overcomes the safety risk. The presence of ACPA and the concurrent use of + cs-DMARD may increase the survival on JAKi in the long term.PMID:38530664 | DOI:10.55563/clinexprheumatol/za0hpu (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 26, 2024 Category: Rheumatology Authors: Marco Sebastiani Alen Zabotti Bruno Biasi Sofia Cacioppo Gilda Sandri Ivan Giovannini Andreina Manfredi Luca Quartuccio Source Type: research
Macrophage re-programming by JAK inhibitors relies on MAFB
Cell Mol Life Sci. 2024 Mar 25;81(1):152. doi: 10.1007/s00018-024-05196-1.ABSTRACTMonocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial tissue-infiltrating macrophage subsets is associated with either active disease or inflammation resolution. JAK inhibitors (JAKi) are the first targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) approved for treatment of RA with comparable efficacy to biologics. However, the effects of JAKi on macrophage specification and differentiation are currently unknown. We have ana...
Source: Cellular and Molecular Life Sciences : CMLS - March 26, 2024 Category: Cytology Authors: Baltasar L ópez-Navarro Miriam Sim ón-Fuentes Israel R íos Mar ía Teresa Schiaffino Alicia Sanchez M ónica Torres-Torresano Alicia Nieto-Valle Isabel Castrej ón Amaya Puig-Kr öger Source Type: research
Bispecific antibodies tethering innate receptors induce human tolerant dendritic cells and regulatory T cells
There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many auto-immune and inflammatory diseases and organ transplantations. Here we describe a bispecific antibody (bsAb) strategy tethering two pathogenrecognition receptors at the surface of human DCs. This cross-linking switches DCs into a tolerant profile able to induce regulatory T-cell differentiation. The bsAbs, not parental Abs, induced interleukin 10 and transforming growth factor b1 secretion in monocyte-derived DCs and human peripheral blood mononuclear cells. In addition, they induced ...
Source: Frontiers in Immunology - March 26, 2024 Category: Allergy & Immunology Source Type: research
Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission
ConclusionThis study reported unexplored associations between different pathologies and myeloid cell subtypes. We also identified a fibroblast-and-M2-like cluster named COL3A1+ Mp, which potentially contributes to synovial immune homeostasis. Targeting the development of COL3A1+ Mp may hold promise for inducing RA remission. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 26, 2024 Category: Allergy & Immunology Source Type: research
Evaluation of diagnostic and therapeutic delay in patients with rheumatoid arthritis and psoriatic arthritis
CONCLUSIONS: According to our results, greater diagnostic delay was found in PsA compared to RA, in patients living in small-medium cities, in those who did not receive the diagnosis from a rheumatologist, in those who were previously misdiagnosed, and in seronegative RA.PMID:38523584 | DOI:10.4081/reumatismo.2024.1607 (Source: Reumatismo)
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: M Iacovantuono S Ferrigno P Conigliaro P Triggianese A D'Antonio F R Spinelli A Bergamini M S Chimenti Source Type: research
Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research
Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2024 Category: Molecular Biology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research
A large cohort comparison of very late-onset systemic lupus erythematosus with younger-onset patients
CONCLUSIONS: Compared with younger patients, in vlSLE, female predominance is less pronounced. Arthritis, anti-dsDNA antibodies and low C3 levels are less frequent. SS and RA are more common. Despite lower disease activity, vlSLE patients have the lowest survival rate. While uncommon, SLE should not be excluded as a possible diagnosis in the elderly.PMID:38526004 | DOI:10.55563/clinexprheumatol/jgsyos (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Luisa Viveiros Ana Neves Teresa Gouveia David A Isenberg Source Type: research
Elevated DAS28-ESR in patients with rheumatoid arthritis who have comorbid fibromyalgia is associated more with tender joint counts than with patient global assessment or swollen joint counts: implications for assessment of inflammatory activity
CONCLUSIONS: DAS28-ESR is elevated significantly in FM+ vs. FM- RA patients; pooled effect sizes were highest for TJC, followed by PATGL, SJC and ESR. The findings appear relevant to response and remission criteria, treat-to-target, and general management of RA.PMID:38525998 | DOI:10.55563/clinexprheumatol/vfvso2 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Sandhya Kannayiram Juan Schmukler Tengfei Li Nicola Goodson Aarthi Sridhar Theodore Pincus Source Type: research
An Unusual Case of Non-typhoidal Salmonella Bacteremia Causing Life-Threatening Aortitis
Cureus. 2024 Feb 21;16(2):e54645. doi: 10.7759/cureus.54645. eCollection 2024 Feb.ABSTRACTNon-typhoidal Salmonella typically presents with gastroenteritis. However, an invasive Salmonella infection, which may be typically seen in immunocompromised patients, has a propensity for aortic involvement, especially in patients with risk factors for atherosclerosis. Here we present a 60-year-old female with multiple comorbid conditions and currently on immunosuppressants for rheumatoid arthritis, who presented with nausea, vomiting, and fever of three weeks duration and was found to have Salmonella bacteremia. Blood cultures were ...
Source: Atherosclerosis - March 25, 2024 Category: Cardiology Authors: Fawwad A Ansari Stefan Gafoor Mubashira Aftab Zola Nlandu Source Type: research
Varicella-Zoster Meningitis and Myelitis After Herpes Zoster Dermatitis Treatment With Amenamevir: A Case Series and Literature Review
In this report, we present four cases of VZV meningitis and myelitis following amenamevir treatment for HZ dermatitis with positive VZV DNA in cerebrospinal fluid (CSF) revealed by polymerase chain reaction (PCR). Three of them were considered immunocompromised hosts given the fact that two of these patients were taking immunosuppressive drugs for rheumatoid arthritis, and one patient had a history of sigmoid colon cancer (four months after resection). After HZ onset, amenamevir, which has poor CSF transfer, was prescribed for all the patients, and all of them developed central nervous complications by VZV (meningitis in t...
Source: Herpes - March 25, 2024 Category: Infectious Diseases Authors: Satoru Tada Yuta Kaito Akihiro Watanabe Yukio Sugiyama Akira Nishigaichi Takashi Miwa Kotaro Watanabe Takanori Hazama Daisuke Takahashi Source Type: research
Evaluation of diagnostic and therapeutic delay in patients with rheumatoid arthritis and psoriatic arthritis
CONCLUSIONS: According to our results, greater diagnostic delay was found in PsA compared to RA, in patients living in small-medium cities, in those who did not receive the diagnosis from a rheumatologist, in those who were previously misdiagnosed, and in seronegative RA.PMID:38523584 | DOI:10.4081/reumatismo.2024.1607 (Source: Reumatismo)
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: M Iacovantuono S Ferrigno P Conigliaro P Triggianese A D'Antonio F R Spinelli A Bergamini M S Chimenti Source Type: research
Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research
Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2024 Category: Molecular Biology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research
